locus-tag	class	description
ACIS_00003	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACIS_00006	COG0772	Belongs to the SEDS family
ACIS_00007	COG0776	regulation of translation
ACIS_00011	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIS_00012	COG0180	Tryptophanyl-tRNA synthetase
ACIS_00013	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACIS_00015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIS_00015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIS_00019	COG4974	Belongs to the 'phage' integrase family
ACIS_00022	COG0280	phosphate acetyltransferase
ACIS_00022	COG0281	malic enzyme
ACIS_00027	COG0651	ATP synthesis coupled electron transport
ACIS_00034	COG0477	Major facilitator Superfamily
ACIS_00035	COG0228	four-way junction DNA binding
ACIS_00037	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACIS_00041	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACIS_00042	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACIS_00045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACIS_00056	COG2022	thiamine diphosphate biosynthetic process
ACIS_00061	COG1840	ABC-type Fe3 transport system, periplasmic component
ACIS_00066	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACIS_00073	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACIS_00075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACIS_00076	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACIS_00078	COG2171	N-acyltransferase activity
ACIS_00092	COG2948	multi-organism process
ACIS_00093	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ACIS_00094	COG3505	Type IV secretory pathway VirD4
ACIS_00095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACIS_00096	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACIS_00097	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACIS_00098	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACIS_00099	COG2226	methyltransferase
ACIS_00100	COG4695	Portal protein
ACIS_00103	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACIS_00104	COG1845	cytochrome c oxidase, subunit III
ACIS_00106	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACIS_00107	COG0157	Belongs to the NadC ModD family
ACIS_00108	COG0484	heat shock protein binding
ACIS_00109	COG0751	glycine-tRNA ligase activity
ACIS_00110	COG0752	glycyl-tRNA synthetase alpha subunit
ACIS_00112	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIS_00113	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACIS_00115	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ACIS_00119	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACIS_00121	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACIS_00123	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACIS_00124	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACIS_00125	COG0670	Belongs to the BI1 family
ACIS_00126	COG0802	atpase or kinase
ACIS_00127	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACIS_00128	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACIS_00129	COG1058	Belongs to the CinA family
ACIS_00129	COG1546	Belongs to the CinA family
ACIS_00130	COG0335	large ribosomal subunit rRNA binding
ACIS_00133	COG1475	DNA binding
ACIS_00134	COG1192	Involved in chromosome partitioning
ACIS_00135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACIS_00141	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACIS_00154	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACIS_00155	COG0556	nucleotide-excision repair
ACIS_00164	COG1573	uracil-dna glycosylase
ACIS_00165	COG0242	peptide deformylase activity
ACIS_00169	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACIS_00170	COG0728	peptidoglycan biosynthetic process
ACIS_00180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACIS_00186	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACIS_00186	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACIS_00187	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACIS_00188	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACIS_00189	COG1127	ABC transporter
ACIS_00192	COG0142	geranyltranstransferase activity
ACIS_00193	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACIS_00194	COG0174	glutamine synthetase
ACIS_00197	COG0156	8-amino-7-oxononanoate synthase activity
ACIS_00201	COG0768	penicillin binding
ACIS_00202	COG1830	Aldolase
ACIS_00204	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIS_00208	COG0519	Catalyzes the synthesis of GMP from XMP
ACIS_00209	COG0372	Belongs to the citrate synthase family
ACIS_00217	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIS_00219	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACIS_00220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACIS_00222	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACIS_00224	COG1138	Cytochrome C-type biogenesis protein
ACIS_00228	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACIS_00235	COG1396	sequence-specific DNA binding
ACIS_00236	COG0105	UTP biosynthetic process
ACIS_00237	COG0617	tRNA 3'-terminal CCA addition
ACIS_00240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ACIS_00240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACIS_00241	COG0473	3-isopropylmalate dehydrogenase activity
ACIS_00243	COG0552	protein localization to endoplasmic reticulum
ACIS_00244	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACIS_00245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACIS_00247	COG1230	cation diffusion facilitator family transporter
ACIS_00250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIS_00252	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACIS_00253	COG0849	cell division
ACIS_00256	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIS_00259	COG0371	Dehydrogenase
ACIS_00261	COG3346	SURF1 family
ACIS_00262	COG0741	lytic transglycosylase activity
ACIS_00263	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIS_00264	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACIS_00265	COG0138	bifunctional purine biosynthesis protein purh
ACIS_00266	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACIS_00268	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIS_00269	COG0750	zinc metalloprotease
ACIS_00272	COG1686	Belongs to the peptidase S11 family
ACIS_00275	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIS_00276	COG0024	Methionine aminopeptidase
ACIS_00279	COG2890	protein-(glutamine-N5) methyltransferase activity
ACIS_00280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACIS_00281	COG0196	riboflavin kinase activity
ACIS_00282	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACIS_00283	COG0612	Peptidase, M16
ACIS_00290	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ACIS_00291	COG0571	ribonuclease III activity
ACIS_00293	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIS_00294	COG0330	HflC and HflK could
ACIS_00296	COG0330	HflC and HflK could
ACIS_00318	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACIS_00319	COG2967	ApaG domain
ACIS_00323	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACIS_00324	COG0489	protein tyrosine kinase activity
ACIS_00326	COG3827	peptidoglycan binding
ACIS_00328	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACIS_00329	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACIS_00330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACIS_00333	COG0745	RESPONSE REGULATOR receiver
ACIS_00336	COG0592	DNA-directed DNA polymerase activity
ACIS_00337	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACIS_00340	COG0151	Belongs to the GarS family
ACIS_00341	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIS_00343	COG0109	protoheme IX farnesyltransferase activity
ACIS_00344	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIS_00345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACIS_00347	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIS_00348	COG2226	methyltransferase
ACIS_00350	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACIS_00352	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACIS_00356	COG4974	Belongs to the 'phage' integrase family
ACIS_00357	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACIS_00367	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACIS_00369	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACIS_00374	COG1494	fructose-1,6-bisphosphatase
ACIS_00378	COG0047	phosphoribosylformylglycinamidine synthase activity
ACIS_00384	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACIS_00386	COG3485	protocatechuate 3,4-dioxygenase
ACIS_00390	COG0542	response to heat
ACIS_00391	COG1028	Short-chain dehydrogenase reductase Sdr
ACIS_00394	COG0459	protein refolding
ACIS_00395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACIS_00396	COG2003	Belongs to the UPF0758 family
ACIS_00397	COG0321	lipoyl(octanoyl) transferase activity
ACIS_00399	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACIS_00401	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACIS_00402	COG0114	fumarate hydratase activity
ACIS_00406	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACIS_00412	COG1074	ATP-dependent DNA helicase activity
ACIS_00417	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ACIS_00422	COG0776	regulation of translation
ACIS_00423	COG0616	signal peptide processing
ACIS_00424	COG0539	negative regulation of cytoplasmic translation
ACIS_00425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACIS_00426	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACIS_00428	COG0051	transcription antitermination factor activity, RNA binding
ACIS_00430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACIS_00431	COG0088	Forms part of the polypeptide exit tunnel
ACIS_00432	COG0089	rRNA binding
ACIS_00433	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACIS_00434	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACIS_00435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACIS_00436	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACIS_00440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACIS_00442	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACIS_00443	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACIS_00444	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACIS_00446	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACIS_00447	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACIS_00449	COG0201	protein transport
ACIS_00450	COG0563	adenylate kinase activity
ACIS_00451	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACIS_00455	COG0203	ribosomal protein L17
ACIS_00461	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACIS_00466	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACIS_00467	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIS_00471	COG0343	queuine tRNA-ribosyltransferase activity
ACIS_00472	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACIS_00473	COG0416	fatty acid biosynthetic process
ACIS_00475	COG0590	tRNA wobble adenosine to inosine editing
ACIS_00482	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACIS_00486	COG2885	chlorophyll binding
ACIS_00492	COG2111	Na H antiporter
ACIS_00494	COG1530	ribonuclease E activity
ACIS_00499	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACIS_00509	COG0564	pseudouridine synthase activity
ACIS_00518	COG0581	inorganic phosphate transmembrane transporter activity
ACIS_00520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACIS_00522	COG3451	type IV secretory pathway VirB4
ACIS_00524	COG3704	protein secretion by the type IV secretion system
ACIS_00526	COG1340	protein secretion by the type IV secretion system
ACIS_00526	COG3704	protein secretion by the type IV secretion system
ACIS_00534	COG0756	dUTP diphosphatase activity
ACIS_00537	COG0505	Belongs to the CarA family
ACIS_00540	COG1160	GTP binding
ACIS_00543	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIS_00545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACIS_00550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACIS_00553	COG0723	plastoquinol--plastocyanin reductase activity
ACIS_00554	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACIS_00562	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACIS_00563	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACIS_00565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACIS_00566	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIS_00567	COG0408	coproporphyrinogen oxidase activity
ACIS_00579	COG0713	ATP synthesis coupled electron transport
ACIS_00580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIS_00583	COG1007	ATP synthesis coupled electron transport
ACIS_00584	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACIS_00589	COG0805	protein transport
ACIS_00590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIS_00592	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACIS_00592	COG0195	Participates in both transcription termination and antitermination
ACIS_00597	COG0861	Integral membrane protein TerC family
ACIS_00614	COG0681	Belongs to the peptidase S26 family
ACIS_00619	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACIS_00620	COG0181	hydroxymethylbilane synthase activity
ACIS_00621	COG0285	dihydrofolate synthase activity
ACIS_00622	COG0154	amidase activity
ACIS_00625	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACIS_00629	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIS_00640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACIS_00641	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACIS_00645	COG0101	tRNA pseudouridine synthase activity
ACIS_00647	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ACIS_00649	COG2945	thiolester hydrolase activity
ACIS_00651	COG1104	cysteine desulfurase activity
ACIS_00652	COG0822	iron-sulfur transferase activity
ACIS_00653	COG0316	Belongs to the HesB IscA family
ACIS_00654	COG0484	heat shock protein binding
ACIS_00655	COG0443	Heat shock 70 kDa protein
ACIS_00656	COG0633	Ferredoxin
ACIS_00658	COG3088	subunit of a heme lyase
ACIS_00662	COG0187	DNA topoisomerase II activity
ACIS_00664	COG1034	ATP synthesis coupled electron transport
ACIS_00671	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACIS_00676	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACIS_00681	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACIS_00689	COG0606	chelatase, subunit chli
ACIS_00690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACIS_00694	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACIS_00695	COG0302	gtp cyclohydrolase
ACIS_00696	COG0312	modulator of DNA gyrase
ACIS_00710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACIS_00712	COG0275	rRNA processing
ACIS_00718	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACIS_00724	COG0708	Exodeoxyribonuclease III
ACIS_00725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACIS_00728	COG1028	Short-chain dehydrogenase reductase Sdr
ACIS_00740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACIS_00742	COG0698	ribose 5-phosphate isomerase
ACIS_00750	COG0149	triose-phosphate isomerase activity
ACIS_00751	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACIS_00753	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACIS_00756	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACIS_00776	COG0481	GTPase activity
ACIS_00780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACIS_00790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIS_00793	COG0450	alkyl hydroperoxide reductase
ACIS_00794	COG0492	ferredoxin-NADP+ reductase activity
ACIS_00795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACIS_00802	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACIS_00803	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACIS_00803	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACIS_00811	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACIS_00813	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACIS_00814	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACIS_00815	COG0358	DNA primase activity
ACIS_00820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACIS_00822	COG3932	Exopolysaccharide synthesis, ExoD
ACIS_00826	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIS_00827	COG3706	GGDEF domain
ACIS_00827	COG0745	RESPONSE REGULATOR receiver
ACIS_00828	COG0564	pseudouridine synthase activity
ACIS_00837	COG0493	'glutamate synthase
ACIS_00837	COG0543	2 iron, 2 sulfur cluster binding
ACIS_00840	COG1183	phosphatidylcholine synthase activity
ACIS_00841	COG0706	membrane insertase activity
ACIS_00842	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACIS_00846	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIS_00847	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIS_00848	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIS_00850	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ACIS_00852	COG0084	hydrolase, TatD family'
ACIS_00862	COG0009	L-threonylcarbamoyladenylate synthase
ACIS_00867	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACIS_00870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACIS_00873	COG0629	single-stranded DNA binding
ACIS_00875	COG0477	Major facilitator Superfamily
ACIS_00877	COG0477	Major facilitator Superfamily
ACIS_00880	COG0113	porphobilinogen synthase activity
ACIS_00883	COG0477	Major facilitator Superfamily
ACIS_00887	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACIS_00892	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACIS_00905	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ACIS_00908	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACIS_00917	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACIS_00956	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACIS_00958	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIS_00959	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIS_00963	COG0758	DNA mediated transformation
ACIS_00966	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACIS_00970	COG0848	biopolymer transport protein
ACIS_00973	COG2202	Pas domain
ACIS_00973	COG2205	protein histidine kinase activity
ACIS_00974	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIS_00980	COG1674	ftsk spoiiie
ACIS_00984	COG4536	flavin adenine dinucleotide binding
ACIS_00989	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACIS_00990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACIS_00991	COG0740	serine-type endopeptidase activity
ACIS_00999	COG0628	permease
ACIS_01001	COG0351	phosphomethylpyrimidine kinase
ACIS_01004	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ACIS_01006	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACIS_01007	COG0587	DNA-directed DNA polymerase activity
ACIS_01016	COG0400	carboxylic ester hydrolase activity
ACIS_01017	COG0242	peptide deformylase activity
ACIS_01024	COG0156	8-amino-7-oxononanoate synthase activity
ACIS_01030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACIS_01032	COG0085	RNA polymerase activity
ACIS_01033	COG0222	ribosome binding
ACIS_01034	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACIS_01035	COG0081	regulation of translation
ACIS_01036	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACIS_01038	COG0250	Participates in transcription elongation, termination and antitermination
ACIS_01044	COG0049	tRNA binding
ACIS_01045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACIS_01052	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIS_01059	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACIS_01065	COG0573	inorganic phosphate transmembrane transporter activity
ACIS_01074	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIS_01077	COG2204	response regulator
ACIS_01079	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACIS_01082	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACIS_01083	COG0546	phosphoglycolate phosphatase activity
ACIS_01086	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACIS_01086	COG0574	Belongs to the PEP-utilizing enzyme family
ACIS_01088	COG0651	ATP synthesis coupled electron transport
ACIS_01090	COG3474	cytochrome
ACIS_01101	COG0194	GDP metabolic process
ACIS_01102	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACIS_01103	COG0632	four-way junction helicase activity
ACIS_01104	COG2255	four-way junction helicase activity
ACIS_01105	COG2814	Major facilitator Superfamily
ACIS_01108	COG1053	succinate dehydrogenase
ACIS_01114	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACIS_01119	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACIS_01124	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACIS_01126	COG5000	phosphorelay sensor kinase activity
ACIS_01127	COG1278	Cold shock
ACIS_01129	COG0717	Belongs to the dCTP deaminase family
ACIS_01133	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACIS_01134	COG1612	heme a metabolic process
ACIS_01136	COG0124	histidyl-tRNA synthetase
ACIS_01137	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACIS_01142	COG0575	Belongs to the CDS family
ACIS_01143	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACIS_01144	COG0233	cytoplasmic translational termination
ACIS_01151	COG0307	riboflavin synthase, alpha
ACIS_01153	COG0739	heme binding
ACIS_01154	COG0612	Peptidase, M16
ACIS_01155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACIS_01156	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACIS_01159	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACIS_01160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACIS_01163	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACIS_01164	COG0516	GMP reductase activity
ACIS_01164	COG0517	IMP dehydrogenase activity
ACIS_01167	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACIS_01170	COG1722	exodeoxyribonuclease VII activity
ACIS_01178	COG0484	heat shock protein binding
ACIS_01185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACIS_01186	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACIS_01191	COG1040	competence protein
ACIS_01192	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACIS_01197	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIS_01197	COG0022	dehydrogenase e1 component
ACIS_01199	COG0312	modulator of DNA gyrase
ACIS_01200	COG0012	GTP binding
ACIS_01202	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACIS_01202	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity