locus-tag	class	description
AMF_001	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AMF_005	COG0772	Belongs to the SEDS family
AMF_006	COG0776	regulation of translation
AMF_010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMF_011	COG0180	Tryptophanyl-tRNA synthetase
AMF_012	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMF_013	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMF_013	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMF_015	COG0504	CTP synthase activity
AMF_018	COG4974	Belongs to the 'phage' integrase family
AMF_020	COG0280	phosphate acetyltransferase
AMF_020	COG0281	malic enzyme
AMF_022	COG0651	ATP synthesis coupled electron transport
AMF_028	COG2022	thiamine diphosphate biosynthetic process
AMF_035	COG0477	Major facilitator Superfamily
AMF_037	COG0228	four-way junction DNA binding
AMF_038	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMF_043	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMF_045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMF_050	COG1840	ABC-type Fe3 transport system, periplasmic component
AMF_053	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMF_061	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMF_062	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMF_063	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMF_071	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMF_073	COG0516	GMP reductase activity
AMF_073	COG0517	IMP dehydrogenase activity
AMF_074	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMF_077	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMF_078	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMF_081	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AMF_083	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMF_084	COG0612	Peptidase, M16
AMF_085	COG0739	heme binding
AMF_087	COG0307	riboflavin synthase, alpha
AMF_095	COG0233	cytoplasmic translational termination
AMF_096	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMF_097	COG4589	Belongs to the CDS family
AMF_100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMF_1006	COG1570	exodeoxyribonuclease VII activity
AMF_1009	COG2171	N-acyltransferase activity
AMF_101	COG0124	histidyl-tRNA synthetase
AMF_1011	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMF_1012	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMF_1014	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AMF_1015	COG0193	aminoacyl-tRNA hydrolase activity
AMF_1016	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AMF_1020	COG1040	competence protein
AMF_1021	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMF_1025	COG0022	dehydrogenase e1 component
AMF_1025	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMF_1027	COG0312	modulator of DNA gyrase
AMF_1028	COG0012	GTP binding
AMF_103	COG1612	heme a metabolic process
AMF_1030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMF_1030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMF_1033	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMF_1036	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMF_104	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMF_1047	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMF_1048	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AMF_106	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMF_107	COG0717	Belongs to the dCTP deaminase family
AMF_109	COG1278	Cold shock
AMF_110	COG5000	phosphorelay sensor kinase activity
AMF_112	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMF_116	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AMF_120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMF_121	COG0359	binds to the 23S rRNA
AMF_122	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMF_125	COG1053	succinate dehydrogenase
AMF_128	COG2814	Major facilitator Superfamily
AMF_129	COG2255	four-way junction helicase activity
AMF_130	COG0632	four-way junction helicase activity
AMF_131	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMF_132	COG0194	GDP metabolic process
AMF_142	COG3474	cytochrome
AMF_144	COG0651	ATP synthesis coupled electron transport
AMF_145	COG0574	Belongs to the PEP-utilizing enzyme family
AMF_145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMF_147	COG0546	phosphoglycolate phosphatase activity
AMF_148	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMF_151	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMF_153	COG2204	response regulator
AMF_156	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMF_163	COG0573	inorganic phosphate transmembrane transporter activity
AMF_169	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AMF_173	COG3038	cytochrome b561
AMF_175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMF_182	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMF_183	COG0049	tRNA binding
AMF_185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMF_188	COG0250	Participates in transcription elongation, termination and antitermination
AMF_190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMF_191	COG0081	regulation of translation
AMF_192	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMF_193	COG0222	ribosome binding
AMF_194	COG0085	RNA polymerase activity
AMF_195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMF_199	COG0156	8-amino-7-oxononanoate synthase activity
AMF_201	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMF_204	COG0242	peptide deformylase activity
AMF_205	COG0400	carboxylic ester hydrolase activity
AMF_213	COG0587	DNA-directed DNA polymerase activity
AMF_214	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMF_217	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AMF_219	COG0352	thiamine-phosphate diphosphorylase activity
AMF_219	COG0351	phosphomethylpyrimidine kinase
AMF_221	COG0628	permease
AMF_230	COG0740	serine-type endopeptidase activity
AMF_231	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMF_232	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMF_235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AMF_237	COG4536	flavin adenine dinucleotide binding
AMF_240	COG1674	ftsk spoiiie
AMF_243	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMF_244	COG2205	protein histidine kinase activity
AMF_244	COG2202	Pas domain
AMF_246	COG0848	biopolymer transport protein
AMF_248	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMF_249	COG0758	DNA mediated transformation
AMF_252	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMF_253	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMF_256	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AMF_279	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMF_285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AMF_287	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AMF_297	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMF_301	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMF_304	COG0477	Major facilitator Superfamily
AMF_306	COG0113	porphobilinogen synthase activity
AMF_310	COG0629	single-stranded DNA binding
AMF_312	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMF_313	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMF_316	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMF_320	COG0009	L-threonylcarbamoyladenylate synthase
AMF_324	COG1758	RNA polymerase activity
AMF_328	COG0084	hydrolase, TatD family'
AMF_330	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AMF_331	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMF_332	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMF_333	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMF_334	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMF_337	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMF_339	COG0706	membrane insertase activity
AMF_340	COG1183	phosphatidylcholine synthase activity
AMF_342	COG0543	2 iron, 2 sulfur cluster binding
AMF_342	COG0493	'glutamate synthase
AMF_345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMF_347	COG0564	pseudouridine synthase activity
AMF_349	COG0745	RESPONSE REGULATOR receiver
AMF_349	COG3706	GGDEF domain
AMF_350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMF_352	COG2902	Dehydrogenase
AMF_353	COG3932	Exopolysaccharide synthesis, ExoD
AMF_355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMF_361	COG0358	DNA primase activity
AMF_363	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMF_365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMF_366	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMF_372	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMF_372	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMF_373	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMF_375	COG0736	holo-[acyl-carrier-protein] synthase activity
AMF_379	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMF_380	COG0492	ferredoxin-NADP+ reductase activity
AMF_381	COG0450	alkyl hydroperoxide reductase
AMF_383	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMF_390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMF_391	COG1185	polyribonucleotide nucleotidyltransferase activity
AMF_393	COG0481	GTPase activity
AMF_409	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AMF_413	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMF_415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMF_416	COG0149	triose-phosphate isomerase activity
AMF_420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AMF_421	COG0039	L-malate dehydrogenase activity
AMF_425	COG0698	ribose 5-phosphate isomerase
AMF_426	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMF_436	COG1028	Short-chain dehydrogenase reductase Sdr
AMF_440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMF_441	COG0708	Exodeoxyribonuclease III
AMF_446	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMF_449	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMF_452	COG0275	rRNA processing
AMF_453	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMF_462	COG0312	modulator of DNA gyrase
AMF_463	COG0302	gtp cyclohydrolase
AMF_464	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMF_467	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMF_468	COG0606	chelatase, subunit chli
AMF_473	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMF_478	COG1034	ATP synthesis coupled electron transport
AMF_480	COG0187	DNA topoisomerase II activity
AMF_482	COG3088	subunit of a heme lyase
AMF_484	COG0633	Ferredoxin
AMF_485	COG0443	Heat shock 70 kDa protein
AMF_486	COG0484	heat shock protein binding
AMF_487	COG0316	Belongs to the HesB IscA family
AMF_488	COG0822	iron-sulfur transferase activity
AMF_489	COG1104	cysteine desulfurase activity
AMF_491	COG2945	thiolester hydrolase activity
AMF_492	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AMF_494	COG0101	tRNA pseudouridine synthase activity
AMF_498	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMF_499	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMF_502	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AMF_511	COG1381	Involved in DNA repair and RecF pathway recombination
AMF_515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMF_519	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMF_521	COG0154	amidase activity
AMF_522	COG0285	dihydrofolate synthase activity
AMF_523	COG0181	hydroxymethylbilane synthase activity
AMF_524	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMF_528	COG0681	Belongs to the peptidase S26 family
AMF_529	COG0316	Belongs to the HesB IscA family
AMF_540	COG0861	Integral membrane protein TerC family
AMF_543	COG0195	Participates in both transcription termination and antitermination
AMF_543	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMF_544	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMF_545	COG0805	protein transport
AMF_548	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMF_549	COG1007	ATP synthesis coupled electron transport
AMF_551	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMF_552	COG0713	ATP synthesis coupled electron transport
AMF_558	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMF_564	COG0408	coproporphyrinogen oxidase activity
AMF_566	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMF_568	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMF_569	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMF_570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMF_580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMF_582	COG0723	plastoquinol--plastocyanin reductase activity
AMF_584	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMF_586	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMF_588	COG0424	maF-like protein
AMF_591	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMF_592	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMF_593	COG1160	GTP binding
AMF_595	COG0505	Belongs to the CarA family
AMF_597	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMF_598	COG0756	dUTP diphosphatase activity
AMF_603	COG1340	protein secretion by the type IV secretion system
AMF_603	COG3704	protein secretion by the type IV secretion system
AMF_604	COG3704	protein secretion by the type IV secretion system
AMF_606	COG3451	type IV secretory pathway VirB4
AMF_608	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AMF_609	COG0581	inorganic phosphate transmembrane transporter activity
AMF_614	COG0439	Biotin carboxylase
AMF_616	COG0564	pseudouridine synthase activity
AMF_625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMF_626	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMF_629	COG2867	negative regulation of translational initiation
AMF_631	COG1530	ribonuclease E activity
AMF_640	COG2885	chlorophyll binding
AMF_642	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMF_644	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMF_650	COG0590	tRNA wobble adenosine to inosine editing
AMF_652	COG0416	fatty acid biosynthetic process
AMF_654	COG0343	queuine tRNA-ribosyltransferase activity
AMF_657	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMF_658	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMF_671	COG0203	ribosomal protein L17
AMF_675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMF_676	COG0563	adenylate kinase activity
AMF_678	COG0200	Binds to the 23S rRNA
AMF_679	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMF_680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMF_681	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMF_682	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMF_683	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMF_684	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMF_686	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMF_688	COG0255	Belongs to the universal ribosomal protein uL29 family
AMF_690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMF_691	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMF_692	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMF_693	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMF_694	COG0089	rRNA binding
AMF_695	COG0088	Forms part of the polypeptide exit tunnel
AMF_696	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMF_697	COG0051	transcription antitermination factor activity, RNA binding
AMF_699	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMF_700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMF_701	COG0539	negative regulation of cytoplasmic translation
AMF_702	COG0616	signal peptide processing
AMF_707	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMF_710	COG0666	response to abiotic stimulus
AMF_711	COG1074	ATP-dependent DNA helicase activity
AMF_718	COG0114	fumarate hydratase activity
AMF_719	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMF_720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMF_721	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMF_722	COG0321	lipoyl(octanoyl) transferase activity
AMF_723	COG2003	Belongs to the UPF0758 family
AMF_724	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMF_725	COG0459	protein refolding
AMF_726	COG1028	Short-chain dehydrogenase reductase Sdr
AMF_728	COG0542	response to heat
AMF_731	COG3485	protocatechuate 3,4-dioxygenase
AMF_733	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMF_736	COG0047	phosphoribosylformylglycinamidine synthase activity
AMF_737	COG0445	tRNA wobble uridine modification
AMF_738	COG1494	fructose-1,6-bisphosphatase
AMF_742	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMF_743	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMF_747	COG4783	chaperone-mediated protein folding
AMF_751	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMF_752	COG4974	Belongs to the 'phage' integrase family
AMF_758	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMF_760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AMF_761	COG2226	methyltransferase
AMF_762	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMF_766	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMF_767	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMF_768	COG0109	protoheme IX farnesyltransferase activity
AMF_769	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMF_770	COG0151	Belongs to the GarS family
AMF_772	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMF_773	COG0592	DNA-directed DNA polymerase activity
AMF_775	COG0745	RESPONSE REGULATOR receiver
AMF_777	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMF_778	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMF_779	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMF_782	COG0489	protein tyrosine kinase activity
AMF_784	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMF_785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMF_786	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMF_787	COG2967	ApaG domain
AMF_788	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AMF_803	COG0330	HflC and HflK could
AMF_804	COG0330	HflC and HflK could
AMF_807	COG0571	ribonuclease III activity
AMF_808	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AMF_815	COG0612	Peptidase, M16
AMF_816	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMF_817	COG0196	riboflavin kinase activity
AMF_818	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AMF_819	COG2890	protein-(glutamine-N5) methyltransferase activity
AMF_820	COG0024	Methionine aminopeptidase
AMF_821	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMF_824	COG1686	Belongs to the peptidase S11 family
AMF_827	COG0750	zinc metalloprotease
AMF_828	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMF_830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMF_831	COG0138	bifunctional purine biosynthesis protein purh
AMF_832	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMF_834	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMF_835	COG0741	lytic transglycosylase activity
AMF_836	COG3346	SURF1 family
AMF_838	COG0371	Dehydrogenase
AMF_841	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMF_844	COG0849	cell division
AMF_845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMF_847	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMF_852	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMF_853	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMF_854	COG0552	protein localization to endoplasmic reticulum
AMF_855	COG0473	3-isopropylmalate dehydrogenase activity
AMF_856	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AMF_856	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMF_858	COG0617	tRNA 3'-terminal CCA addition
AMF_859	COG0105	UTP biosynthetic process
AMF_860	COG1396	sequence-specific DNA binding
AMF_882	COG1138	Cytochrome C-type biogenesis protein
AMF_884	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMF_886	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMF_887	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMF_888	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMF_896	COG0372	Belongs to the citrate synthase family
AMF_897	COG0519	Catalyzes the synthesis of GMP from XMP
AMF_900	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMF_901	COG1830	Aldolase
AMF_902	COG0768	penicillin binding
AMF_905	COG0156	8-amino-7-oxononanoate synthase activity
AMF_907	COG0174	glutamine synthetase
AMF_908	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMF_909	COG0142	geranyltranstransferase activity
AMF_911	COG1127	ABC transporter
AMF_912	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMF_913	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AMF_916	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMF_917	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMF_929	COG0728	peptidoglycan biosynthetic process
AMF_930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMF_933	COG0242	peptide deformylase activity
AMF_934	COG1573	uracil-dna glycosylase
AMF_941	COG0556	nucleotide-excision repair
AMF_942	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMF_948	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AMF_953	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMF_954	COG1192	Involved in chromosome partitioning
AMF_955	COG1475	DNA binding
AMF_958	COG0336	Belongs to the RNA methyltransferase TrmD family
AMF_959	COG0335	large ribosomal subunit rRNA binding
AMF_960	COG1058	Belongs to the CinA family
AMF_960	COG1546	Belongs to the CinA family
AMF_961	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMF_962	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMF_963	COG0802	atpase or kinase
AMF_964	COG0670	Belongs to the BI1 family
AMF_965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMF_966	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMF_971	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AMF_973	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMF_974	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMF_978	COG0484	heat shock protein binding
AMF_979	COG0157	Belongs to the NadC ModD family
AMF_980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AMF_981	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMF_982	COG1845	cytochrome c oxidase, subunit III
AMF_983	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMF_986	COG4695	Portal protein
AMF_988	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AMF_989	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMF_990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMF_991	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMF_992	COG3505	Type IV secretory pathway VirD4
AMF_993	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AMF_994	COG2948	multi-organism process