locus-tag	class	description
AM001	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AM005	COG0772	Belongs to the SEDS family
AM006	COG0776	regulation of translation
AM010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM011	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM012	COG0180	Tryptophanyl-tRNA synthetase
AM013	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AM015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM021	COG4974	Belongs to the 'phage' integrase family
AM024	COG0280	phosphate acetyltransferase
AM024	COG0281	malic enzyme
AM026	COG0651	ATP synthesis coupled electron transport
AM037	COG2022	thiamine diphosphate biosynthetic process
AM051	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AM053	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AM054	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM058	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM059	COG0228	four-way junction DNA binding
AM060	COG0477	Major facilitator Superfamily
AM069	COG1840	ABC-type Fe3 transport system, periplasmic component
AM073	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AM087	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AM088	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM1000	COG2226	methyltransferase
AM1001	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM1007	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM1008	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM1009	COG0109	protoheme IX farnesyltransferase activity
AM101	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM1010	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM1011	COG0151	Belongs to the GarS family
AM1013	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM1014	COG0592	DNA-directed DNA polymerase activity
AM1016	COG0745	RESPONSE REGULATOR receiver
AM1020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM1022	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM1023	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AM1027	COG0489	protein tyrosine kinase activity
AM1028	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM1030	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM1032	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM1035	COG2967	ApaG domain
AM1036	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM105	COG0516	GMP reductase activity
AM105	COG0517	IMP dehydrogenase activity
AM106	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM1064	COG0330	HflC and HflK could
AM1065	COG0330	HflC and HflK could
AM1070	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AM1080	COG0612	Peptidase, M16
AM1082	COG0196	riboflavin kinase activity
AM1083	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM1084	COG2890	protein-(glutamine-N5) methyltransferase activity
AM1086	COG0024	Methionine aminopeptidase
AM1087	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM1091	COG1686	Belongs to the peptidase S11 family
AM1094	COG0750	zinc metalloprotease
AM1096	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM1098	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AM1099	COG0138	bifunctional purine biosynthesis protein purh
AM110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM1100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM1103	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM1104	COG0741	lytic transglycosylase activity
AM1105	COG3346	SURF1 family
AM1109	COG0371	Dehydrogenase
AM1112	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM1115	COG0849	cell division
AM1116	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AM1119	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1126	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM1128	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AM1129	COG0552	protein localization to endoplasmic reticulum
AM1131	COG0473	3-isopropylmalate dehydrogenase activity
AM1133	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AM1133	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM1136	COG0617	tRNA 3'-terminal CCA addition
AM1137	COG0105	UTP biosynthetic process
AM1138	COG1396	sequence-specific DNA binding
AM114	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AM116	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM1169	COG1138	Cytochrome C-type biogenesis protein
AM117	COG0612	Peptidase, M16
AM1173	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM1174	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AM1175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM118	COG0739	heme binding
AM1187	COG0372	Belongs to the citrate synthase family
AM1192	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM1194	COG1830	Aldolase
AM1196	COG0768	penicillin binding
AM120	COG0307	riboflavin synthase, alpha
AM1202	COG0156	8-amino-7-oxononanoate synthase activity
AM1206	COG0174	glutamine synthetase
AM1207	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM1208	COG0142	geranyltranstransferase activity
AM1210	COG1127	ABC transporter
AM1212	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM1213	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM1217	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AM1218	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM1229	COG0728	peptidoglycan biosynthetic process
AM1231	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AM1236	COG0242	peptide deformylase activity
AM1237	COG1573	uracil-dna glycosylase
AM1245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM1254	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AM1264	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AM1266	COG1192	Involved in chromosome partitioning
AM1267	COG1475	DNA binding
AM1271	COG0335	large ribosomal subunit rRNA binding
AM1272	COG1546	Belongs to the CinA family
AM1272	COG1058	Belongs to the CinA family
AM1274	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AM1275	COG0802	atpase or kinase
AM1276	COG0670	Belongs to the BI1 family
AM1277	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM1278	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AM1286	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AM1288	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AM1289	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM1296	COG0484	heat shock protein binding
AM1297	COG0157	Belongs to the NadC ModD family
AM130	COG0233	cytoplasmic translational termination
AM1300	COG1845	cytochrome c oxidase, subunit III
AM1301	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AM1305	COG4695	Portal protein
AM1307	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM1309	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AM131	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM1310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AM1311	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AM1312	COG3505	Type IV secretory pathway VirD4
AM1313	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AM1314	COG2948	multi-organism process
AM132	COG4589	Belongs to the CDS family
AM1331	COG2171	N-acyltransferase activity
AM1335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM1336	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM1338	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AM1346	COG1040	competence protein
AM1347	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM1351	COG0022	dehydrogenase e1 component
AM1351	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM1353	COG0312	modulator of DNA gyrase
AM1355	COG0012	GTP binding
AM1357	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AM1357	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AM137	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AM147	COG0717	Belongs to the dCTP deaminase family
AM149	COG1278	Cold shock
AM150	COG5000	phosphorelay sensor kinase activity
AM157	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AM168	COG1053	succinate dehydrogenase
AM171	COG2814	Major facilitator Superfamily
AM173	COG0632	four-way junction helicase activity
AM175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM177	COG0194	GDP metabolic process
AM190	COG3474	cytochrome
AM193	COG0651	ATP synthesis coupled electron transport
AM195	COG0574	Belongs to the PEP-utilizing enzyme family
AM195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM198	COG0546	phosphoglycolate phosphatase activity
AM199	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AM200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AM205	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM207	COG2204	response regulator
AM215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM223	COG0573	inorganic phosphate transmembrane transporter activity
AM233	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AM238	COG3038	cytochrome b561
AM241	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM249	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AM250	COG0049	tRNA binding
AM256	COG0250	Participates in transcription elongation, termination and antitermination
AM258	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AM260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AM261	COG0222	ribosome binding
AM263	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AM268	COG0156	8-amino-7-oxononanoate synthase activity
AM275	COG0242	peptide deformylase activity
AM276	COG0400	carboxylic ester hydrolase activity
AM287	COG0587	DNA-directed DNA polymerase activity
AM289	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM292	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM295	COG0351	phosphomethylpyrimidine kinase
AM295	COG0352	thiamine-phosphate diphosphorylase activity
AM297	COG0628	permease
AM309	COG0740	serine-type endopeptidase activity
AM310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AM311	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AM320	COG4536	flavin adenine dinucleotide binding
AM322	COG1674	ftsk spoiiie
AM326	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM327	COG2205	protein histidine kinase activity
AM327	COG2202	Pas domain
AM329	COG0848	biopolymer transport protein
AM332	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM333	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM334	COG0758	DNA mediated transformation
AM338	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM339	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AM343	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AM384	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM392	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AM396	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AM412	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AM415	COG0477	Major facilitator Superfamily
AM417	COG0113	porphobilinogen synthase activity
AM424	COG0629	single-stranded DNA binding
AM428	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AM432	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AM436	COG0009	L-threonylcarbamoyladenylate synthase
AM447	COG0084	hydrolase, TatD family'
AM452	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM453	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM454	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM458	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AM460	COG0706	membrane insertase activity
AM462	COG1183	phosphatidylcholine synthase activity
AM465	COG0543	2 iron, 2 sulfur cluster binding
AM465	COG0493	'glutamate synthase
AM474	COG0564	pseudouridine synthase activity
AM475	COG3706	GGDEF domain
AM475	COG0745	RESPONSE REGULATOR receiver
AM476	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM477	COG2902	Dehydrogenase
AM480	COG3932	Exopolysaccharide synthesis, ExoD
AM483	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM488	COG0358	DNA primase activity
AM490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM492	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM493	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AM501	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM501	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM502	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM509	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AM510	COG0492	ferredoxin-NADP+ reductase activity
AM511	COG0450	alkyl hydroperoxide reductase
AM516	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM528	COG0481	GTPase activity
AM552	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AM556	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AM558	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM559	COG0149	triose-phosphate isomerase activity
AM563	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AM566	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM570	COG0698	ribose 5-phosphate isomerase
AM571	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM584	COG1028	Short-chain dehydrogenase reductase Sdr
AM590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM591	COG0708	Exodeoxyribonuclease III
AM596	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AM606	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM618	COG0312	modulator of DNA gyrase
AM619	COG0302	gtp cyclohydrolase
AM620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AM625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM626	COG0606	chelatase, subunit chli
AM631	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM641	COG1034	ATP synthesis coupled electron transport
AM644	COG0187	DNA topoisomerase II activity
AM647	COG3088	subunit of a heme lyase
AM650	COG0633	Ferredoxin
AM651	COG0443	Heat shock 70 kDa protein
AM652	COG0484	heat shock protein binding
AM654	COG0822	iron-sulfur transferase activity
AM655	COG1104	cysteine desulfurase activity
AM657	COG2945	thiolester hydrolase activity
AM658	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AM664	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AM669	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AM685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM692	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AM698	COG0154	amidase activity
AM699	COG0285	dihydrofolate synthase activity
AM700	COG0181	hydroxymethylbilane synthase activity
AM701	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AM708	COG0681	Belongs to the peptidase S26 family
AM709	COG0316	Belongs to the HesB IscA family
AM733	COG0861	Integral membrane protein TerC family
AM736	COG0195	Participates in both transcription termination and antitermination
AM736	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AM738	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM740	COG0805	protein transport
AM743	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AM744	COG1007	ATP synthesis coupled electron transport
AM745	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM746	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM747	COG0713	ATP synthesis coupled electron transport
AM762	COG0408	coproporphyrinogen oxidase activity
AM764	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AM767	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AM769	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM771	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AM783	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AM784	COG0723	plastoquinol--plastocyanin reductase activity
AM789	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM797	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM798	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM801	COG1160	GTP binding
AM803	COG0505	Belongs to the CarA family
AM805	COG0756	dUTP diphosphatase activity
AM811	COG3704	protein secretion by the type IV secretion system
AM811	COG1340	protein secretion by the type IV secretion system
AM812	COG3704	protein secretion by the type IV secretion system
AM814	COG3451	type IV secretory pathway VirB4
AM816	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM818	COG0581	inorganic phosphate transmembrane transporter activity
AM824	COG0439	Biotin carboxylase
AM825	COG0564	pseudouridine synthase activity
AM837	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AM839	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM841	COG2867	negative regulation of translational initiation
AM844	COG1530	ribonuclease E activity
AM854	COG2885	chlorophyll binding
AM860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM868	COG0590	tRNA wobble adenosine to inosine editing
AM870	COG0416	fatty acid biosynthetic process
AM870.5	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AM871	COG0343	queuine tRNA-ribosyltransferase activity
AM875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM876	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM880.5	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AM890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AM891	COG0563	adenylate kinase activity
AM894	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AM895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AM896	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AM897	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AM898	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AM899	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AM901	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AM904	COG0255	Belongs to the universal ribosomal protein uL29 family
AM906	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AM907	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AM908	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AM909	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AM910	COG0089	rRNA binding
AM911	COG0088	Forms part of the polypeptide exit tunnel
AM912	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AM913	COG0051	transcription antitermination factor activity, RNA binding
AM915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM916	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AM917	COG0539	negative regulation of cytoplasmic translation
AM918	COG0616	signal peptide processing
AM923	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM926	COG0666	response to abiotic stimulus
AM927	COG1074	ATP-dependent DNA helicase activity
AM931	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM937	COG0114	fumarate hydratase activity
AM938	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM939	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AM941	COG0321	lipoyl(octanoyl) transferase activity
AM942	COG2003	Belongs to the UPF0758 family
AM943	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AM944	COG0459	protein refolding
AM947	COG1028	Short-chain dehydrogenase reductase Sdr
AM949	COG0542	response to heat
AM953	COG3485	protocatechuate 3,4-dioxygenase
AM957	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM960	COG0047	phosphoribosylformylglycinamidine synthase activity
AM964	COG1494	fructose-1,6-bisphosphatase
AM969	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AM973	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM979	COG4783	chaperone-mediated protein folding
AM983	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AM984	COG4974	Belongs to the 'phage' integrase family
AM992	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AM999	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis