locus-tag	class	description
AOV_00020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOV_00070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AOV_00080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AOV_00085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AOV_00100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOV_00105	COG0228	four-way junction DNA binding
AOV_00110	COG0477	Major facilitator Superfamily
AOV_00125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AOV_00130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AOV_00175	COG3118	belongs to the thioredoxin family
AOV_00185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOV_00210	COG0517	IMP dehydrogenase activity
AOV_00210	COG0516	GMP reductase activity
AOV_00215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AOV_00230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AOV_00235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AOV_00250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AOV_00255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOV_00260	COG0612	Peptidase, M16
AOV_00265	COG0739	heme binding
AOV_00275	COG0307	riboflavin synthase, alpha
AOV_00280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOV_00300	COG0233	cytoplasmic translational termination
AOV_00305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOV_00310	COG4589	Belongs to the CDS family
AOV_00320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AOV_00325	COG0124	histidyl-tRNA synthetase
AOV_00335	COG1612	heme a metabolic process
AOV_00340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AOV_00355	COG0717	Belongs to the dCTP deaminase family
AOV_00365	COG1278	Cold shock
AOV_00370	COG5000	phosphorelay sensor kinase activity
AOV_00380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOV_00400	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AOV_00425	COG0359	binds to the 23S rRNA
AOV_00430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOV_00445	COG1053	succinate dehydrogenase
AOV_00460	COG2814	Major facilitator Superfamily
AOV_00470	COG0632	four-way junction helicase activity
AOV_00475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AOV_00480	COG0194	GDP metabolic process
AOV_00525	COG3474	cytochrome
AOV_00535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOV_00535	COG0574	Belongs to the PEP-utilizing enzyme family
AOV_00545	COG0546	phosphoglycolate phosphatase activity
AOV_00550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOV_00570	COG1181	Belongs to the D-alanine--D-alanine ligase family
AOV_00580	COG2204	response regulator
AOV_00610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOV_00645	COG0573	inorganic phosphate transmembrane transporter activity
AOV_00670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AOV_00700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOV_00735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOV_00740	COG0049	tRNA binding
AOV_00765	COG0250	Participates in transcription elongation, termination and antitermination
AOV_00770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AOV_00775	COG0081	regulation of translation
AOV_00780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOV_00785	COG0222	ribosome binding
AOV_00790	COG0085	RNA polymerase activity
AOV_00795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AOV_00820	COG0156	8-amino-7-oxononanoate synthase activity
AOV_00835	COG0167	dihydroorotate dehydrogenase activity
AOV_00840	COG0242	peptide deformylase activity
AOV_00845	COG0400	carboxylic ester hydrolase activity
AOV_00880	COG0587	DNA-directed DNA polymerase activity
AOV_00890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOV_00905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOV_00915	COG0352	thiamine-phosphate diphosphorylase activity
AOV_00915	COG0351	phosphomethylpyrimidine kinase
AOV_00925	COG0628	permease
AOV_00980	COG0740	serine-type endopeptidase activity
AOV_00985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AOV_00990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AOV_01010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AOV_01030	COG4536	flavin adenine dinucleotide binding
AOV_01040	COG1674	ftsk spoiiie
AOV_01060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOV_01065	COG2205	protein histidine kinase activity
AOV_01065	COG2202	Pas domain
AOV_01075	COG0848	biopolymer transport protein
AOV_01090	COG0758	DNA mediated transformation
AOV_01105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOV_01110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOV_01115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AOV_01125	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AOV_01205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AOV_01230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AOV_01280	COG3842	ATPase activity
AOV_01285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOV_01295	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AOV_01345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOV_01365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AOV_01375	COG0113	porphobilinogen synthase activity
AOV_01390	COG0477	Major facilitator Superfamily
AOV_01395	COG0477	Major facilitator Superfamily
AOV_01400	COG0477	Major facilitator Superfamily
AOV_01415	COG0629	single-stranded DNA binding
AOV_01425	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOV_01435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AOV_01450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AOV_01470	COG0009	L-threonylcarbamoyladenylate synthase
AOV_01510	COG0084	hydrolase, TatD family'
AOV_01520	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AOV_01525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOV_01530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOV_01535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOV_01540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOV_01555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AOV_01560	COG0706	membrane insertase activity
AOV_01565	COG1183	phosphatidylcholine synthase activity
AOV_01575	COG0493	'glutamate synthase
AOV_01575	COG0543	2 iron, 2 sulfur cluster binding
AOV_01600	COG0564	pseudouridine synthase activity
AOV_01605	COG3706	GGDEF domain
AOV_01605	COG0745	RESPONSE REGULATOR receiver
AOV_01610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOV_01620	COG3932	Exopolysaccharide synthesis, ExoD
AOV_01630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOV_01650	COG0358	DNA primase activity
AOV_01655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOV_01660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOV_01665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AOV_01690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AOV_01700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOV_01700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOV_01705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOV_01725	COG0736	holo-[acyl-carrier-protein] synthase activity
AOV_01745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AOV_01755	COG0450	alkyl hydroperoxide reductase
AOV_01765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOV_01805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AOV_01825	COG0481	GTPase activity
AOV_01915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AOV_01930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOV_01940	COG0149	triose-phosphate isomerase activity
AOV_01955	COG1714	RDD family
AOV_01985	COG0698	ribose 5-phosphate isomerase
AOV_01990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOV_02045	COG1028	Short-chain dehydrogenase reductase Sdr
AOV_02060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AOV_02065	COG0708	Exodeoxyribonuclease III
AOV_02095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AOV_02125	COG0275	rRNA processing
AOV_02135	COG0275	rRNA processing
AOV_02140	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOV_02210	COG0312	modulator of DNA gyrase
AOV_02215	COG0302	gtp cyclohydrolase
AOV_02220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AOV_02235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOV_02240	COG0606	chelatase, subunit chli
AOV_02260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOV_02280	COG1034	ATP synthesis coupled electron transport
AOV_02290	COG0187	DNA topoisomerase II activity
AOV_02295	COG0163	prenyltransferase activity
AOV_02300	COG3088	subunit of a heme lyase
AOV_02310	COG0633	Ferredoxin
AOV_02315	COG0443	Heat shock 70 kDa protein
AOV_02320	COG0484	heat shock protein binding
AOV_02325	COG0316	Belongs to the HesB IscA family
AOV_02330	COG0822	iron-sulfur transferase activity
AOV_02335	COG1104	cysteine desulfurase activity
AOV_02340	COG1104	cysteine desulfurase activity
AOV_02345	COG2945	thiolester hydrolase activity
AOV_02350	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AOV_02360	COG0101	tRNA pseudouridine synthase activity
AOV_02370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOV_02375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOV_02405	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AOV_02435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOV_02480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOV_02495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AOV_02505	COG0154	amidase activity
AOV_02510	COG0285	dihydrofolate synthase activity
AOV_02515	COG0181	hydroxymethylbilane synthase activity
AOV_02520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AOV_02550	COG0681	Belongs to the peptidase S26 family
AOV_02555	COG0316	Belongs to the HesB IscA family
AOV_02580	COG0861	Integral membrane protein TerC family
AOV_02595	COG0195	Participates in both transcription termination and antitermination
AOV_02595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOV_02600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOV_02605	COG0805	protein transport
AOV_02620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AOV_02625	COG1007	ATP synthesis coupled electron transport
AOV_02630	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOV_02635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOV_02640	COG0713	ATP synthesis coupled electron transport
AOV_02650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOV_02695	COG0408	coproporphyrinogen oxidase activity
AOV_02700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOV_02705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AOV_02710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AOV_02715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOV_02720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AOV_02790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AOV_02795	COG0723	plastoquinol--plastocyanin reductase activity
AOV_02805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOV_02815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AOV_02825	COG0424	maF-like protein
AOV_02830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AOV_02845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOV_02850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOV_02855	COG1160	GTP binding
AOV_02870	COG0505	Belongs to the CarA family
AOV_02880	COG0756	dUTP diphosphatase activity
AOV_02885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOV_02900	COG3704	protein secretion by the type IV secretion system
AOV_02900	COG1340	protein secretion by the type IV secretion system
AOV_02905	COG3704	protein secretion by the type IV secretion system
AOV_02915	COG3451	type IV secretory pathway VirB4
AOV_02925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOV_02930	COG0581	inorganic phosphate transmembrane transporter activity
AOV_02960	COG0439	Biotin carboxylase
AOV_02965	COG0564	pseudouridine synthase activity
AOV_03010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOV_03035	COG1530	ribonuclease E activity
AOV_03045	COG2111	Na H antiporter
AOV_03075	COG2885	chlorophyll binding
AOV_03095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOV_03130	COG0590	tRNA wobble adenosine to inosine editing
AOV_03140	COG0416	fatty acid biosynthetic process
AOV_03145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AOV_03150	COG0343	queuine tRNA-ribosyltransferase activity
AOV_03170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AOV_03185	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AOV_03210	COG0203	ribosomal protein L17
AOV_03225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AOV_03230	COG0563	adenylate kinase activity
AOV_03235	COG0201	protein transport
AOV_03245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AOV_03250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AOV_03255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AOV_03260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AOV_03265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AOV_03270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AOV_03280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AOV_03290	COG0255	Belongs to the universal ribosomal protein uL29 family
AOV_03300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AOV_03305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AOV_03310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AOV_03315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AOV_03320	COG0089	rRNA binding
AOV_03325	COG0088	Forms part of the polypeptide exit tunnel
AOV_03330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOV_03335	COG0051	transcription antitermination factor activity, RNA binding
AOV_03355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOV_03360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AOV_03365	COG0539	negative regulation of cytoplasmic translation
AOV_03370	COG0616	signal peptide processing
AOV_03375	COG0776	regulation of translation
AOV_03400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOV_03430	COG1074	ATP-dependent DNA helicase activity
AOV_03445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOV_03460	COG0114	fumarate hydratase activity
AOV_03465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOV_03470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AOV_03475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOV_03480	COG0321	lipoyl(octanoyl) transferase activity
AOV_03485	COG2003	Belongs to the UPF0758 family
AOV_03490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AOV_03495	COG0459	protein refolding
AOV_03500	COG1028	Short-chain dehydrogenase reductase Sdr
AOV_03505	COG0542	response to heat
AOV_03520	COG3485	protocatechuate 3,4-dioxygenase
AOV_03530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOV_03555	COG0047	phosphoribosylformylglycinamidine synthase activity
AOV_03565	COG1494	fructose-1,6-bisphosphatase
AOV_03585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AOV_03595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOV_03630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AOV_03635	COG4974	Belongs to the 'phage' integrase family
AOV_03665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AOV_03680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AOV_03685	COG2226	methyltransferase
AOV_03690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOV_03695	COG0527	aspartate kinase activity
AOV_03710	COG0109	protoheme IX farnesyltransferase activity
AOV_03715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOV_03720	COG0151	Belongs to the GarS family
AOV_03730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOV_03745	COG0745	RESPONSE REGULATOR receiver
AOV_03765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AOV_03775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOV_03780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOV_03795	COG0489	protein tyrosine kinase activity
AOV_03800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOV_03805	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOV_03810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOV_03815	COG2967	ApaG domain
AOV_03820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AOV_03955	COG2022	thiamine diphosphate biosynthetic process
AOV_03975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOV_03990	COG0330	HflC and HflK could
AOV_03995	COG0330	HflC and HflK could
AOV_04010	COG0571	ribonuclease III activity
AOV_04015	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AOV_04040	COG0612	Peptidase, M16
AOV_04045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AOV_04050	COG0196	riboflavin kinase activity
AOV_04055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AOV_04060	COG2890	protein-(glutamine-N5) methyltransferase activity
AOV_04065	COG0024	Methionine aminopeptidase
AOV_04070	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOV_04085	COG1686	Belongs to the peptidase S11 family
AOV_04100	COG0750	zinc metalloprotease
AOV_04105	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOV_04115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOV_04120	COG0138	bifunctional purine biosynthesis protein purh
AOV_04125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AOV_04135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOV_04140	COG0741	lytic transglycosylase activity
AOV_04155	COG0371	Dehydrogenase
AOV_04175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOV_04190	COG0849	cell division
AOV_04195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOV_04210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOV_04240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOV_04245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AOV_04250	COG0552	protein localization to endoplasmic reticulum
AOV_04255	COG0473	3-isopropylmalate dehydrogenase activity
AOV_04270	COG0105	UTP biosynthetic process
AOV_04275	COG1396	sequence-specific DNA binding
AOV_04315	COG0651	ATP synthesis coupled electron transport
AOV_04325	COG0280	phosphate acetyltransferase
AOV_04325	COG0281	malic enzyme
AOV_04335	COG4974	Belongs to the 'phage' integrase family
AOV_04350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOV_04350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOV_04355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AOV_04360	COG0180	Tryptophanyl-tRNA synthetase
AOV_04365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOV_04395	COG0776	regulation of translation
AOV_04400	COG0772	Belongs to the SEDS family
AOV_04420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AOV_04420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AOV_04430	COG0012	GTP binding
AOV_04435	COG0312	modulator of DNA gyrase
AOV_04450	COG0022	dehydrogenase e1 component
AOV_04470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOV_04530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AOV_04535	COG1090	epimerase
AOV_04540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOV_04545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOV_04555	COG2171	N-acyltransferase activity
AOV_04620	COG2948	multi-organism process
AOV_04625	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AOV_04635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AOV_04640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AOV_04645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AOV_04655	COG4695	Portal protein
AOV_04670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AOV_04675	COG1845	cytochrome c oxidase, subunit III
AOV_04685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AOV_04690	COG0157	Belongs to the NadC ModD family
AOV_04695	COG0484	heat shock protein binding
AOV_04720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOV_04730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AOV_04740	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AOV_04765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AOV_04770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AOV_04775	COG0670	Belongs to the BI1 family
AOV_04780	COG0802	atpase or kinase
AOV_04795	COG1546	Belongs to the CinA family
AOV_04795	COG1058	Belongs to the CinA family
AOV_04800	COG0335	large ribosomal subunit rRNA binding
AOV_04815	COG1475	DNA binding
AOV_04820	COG1192	Involved in chromosome partitioning
AOV_04825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AOV_04850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AOV_04885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOV_04925	COG1573	uracil-dna glycosylase
AOV_04930	COG0242	peptide deformylase activity
AOV_04950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AOV_04955	COG0728	peptidoglycan biosynthetic process
AOV_05000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AOV_05005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AOV_05025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOV_05030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOV_05035	COG1127	ABC transporter
AOV_05045	COG0142	geranyltranstransferase activity
AOV_05050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOV_05055	COG0174	glutamine synthetase
AOV_05070	COG0156	8-amino-7-oxononanoate synthase activity
AOV_05085	COG0768	penicillin binding
AOV_05095	COG1830	Aldolase
AOV_05105	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOV_05120	COG0372	Belongs to the citrate synthase family
AOV_05160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOV_05165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AOV_05170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOV_05180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AOV_05190	COG1138	Cytochrome C-type biogenesis protein
AOV_05195	COG0354	folic acid binding
AOV_05230	COG1840	ABC-type Fe3 transport system, periplasmic component