locus-tag	class	description
ESP60_00005	COG0084	hydrolase, TatD family'
ESP60_00025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ESP60_00030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ESP60_00035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESP60_00040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESP60_00045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESP60_00055	COG1758	RNA polymerase activity
ESP60_00070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ESP60_00085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ESP60_00090	COG0540	Belongs to the ATCase OTCase family
ESP60_00095	COG0101	tRNA pseudouridine synthase activity
ESP60_00105	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ESP60_00130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ESP60_00165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ESP60_00165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ESP60_00175	COG0217	transcriptional regulatory protein
ESP60_00200	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ESP60_00215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESP60_00225	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ESP60_00230	COG0629	single-stranded DNA binding
ESP60_00285	COG1217	gtp-binding protein TYPA
ESP60_00295	COG0861	Integral membrane protein TerC family
ESP60_00305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ESP60_00310	COG0195	Participates in both transcription termination and antitermination
ESP60_00310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ESP60_00320	COG0805	protein transport
ESP60_00335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ESP60_00340	COG1007	ATP synthesis coupled electron transport
ESP60_00350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ESP60_00355	COG0713	ATP synthesis coupled electron transport
ESP60_00365	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ESP60_00380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ESP60_00400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ESP60_00425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ESP60_00430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ESP60_00450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ESP60_00460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESP60_00470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ESP60_00500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ESP60_00505	COG0723	plastoquinol--plastocyanin reductase activity
ESP60_00515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ESP60_00520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ESP60_00525	COG0052	Belongs to the universal ribosomal protein uS2 family
ESP60_00530	COG0424	maF-like protein
ESP60_00535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ESP60_00545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP60_00550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ESP60_00555	COG1160	GTP binding
ESP60_00560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ESP60_00605	COG0505	Belongs to the CarA family
ESP60_00615	COG0756	dUTP diphosphatase activity
ESP60_00635	COG1340	protein secretion by the type IV secretion system
ESP60_00635	COG3704	protein secretion by the type IV secretion system
ESP60_00640	COG3704	protein secretion by the type IV secretion system
ESP60_00645	COG3704	protein secretion by the type IV secretion system
ESP60_00655	COG3451	type IV secretory pathway VirB4
ESP60_00670	COG0581	inorganic phosphate transmembrane transporter activity
ESP60_00680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ESP60_00695	COG4770	biotin carboxylase activity
ESP60_00700	COG0564	pseudouridine synthase activity
ESP60_00705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ESP60_00730	COG3577	Aspartyl protease
ESP60_00740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ESP60_00745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ESP60_00750	COG1007	ATP synthesis coupled electron transport
ESP60_00770	COG1530	ribonuclease E activity
ESP60_00780	COG2111	Na H antiporter
ESP60_00825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ESP60_00830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP60_00840	COG0142	geranyltranstransferase activity
ESP60_00875	COG0590	tRNA wobble adenosine to inosine editing
ESP60_00890	COG0416	fatty acid biosynthetic process
ESP60_00895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ESP60_00900	COG0343	queuine tRNA-ribosyltransferase activity
ESP60_00910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ESP60_00920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ESP60_00940	COG2333	competence protein COMEC
ESP60_00940	COG0658	competence protein
ESP60_00950	COG0203	ribosomal protein L17
ESP60_00955	COG0202	RNA polymerase activity
ESP60_00960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ESP60_00965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ESP60_00970	COG0563	adenylate kinase activity
ESP60_00975	COG0201	protein transport
ESP60_00985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ESP60_00990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ESP60_00995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ESP60_01000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ESP60_01005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ESP60_01010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ESP60_01015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ESP60_01020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ESP60_01025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ESP60_01030	COG0255	Belongs to the universal ribosomal protein uL29 family
ESP60_01035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ESP60_01040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ESP60_01045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ESP60_01050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ESP60_01055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ESP60_01060	COG0089	rRNA binding
ESP60_01065	COG0088	Forms part of the polypeptide exit tunnel
ESP60_01070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ESP60_01075	COG0051	transcription antitermination factor activity, RNA binding
ESP60_01080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ESP60_01095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESP60_01100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ESP60_01105	COG0539	negative regulation of cytoplasmic translation
ESP60_01110	COG0616	signal peptide processing
ESP60_01115	COG0776	regulation of translation
ESP60_01175	COG1074	ATP-dependent DNA helicase activity
ESP60_01190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ESP60_01220	COG0114	fumarate hydratase activity
ESP60_01225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ESP60_01230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ESP60_01235	COG0321	lipoyl(octanoyl) transferase activity
ESP60_01240	COG2003	Belongs to the UPF0758 family
ESP60_01245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ESP60_01270	COG0542	response to heat
ESP60_01285	COG3485	protocatechuate 3,4-dioxygenase
ESP60_01295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ESP60_01320	COG0445	tRNA wobble uridine modification
ESP60_01325	COG1494	fructose-1,6-bisphosphatase
ESP60_01330	COG4942	peptidase
ESP60_01345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ESP60_01360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ESP60_01365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ESP60_01380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ESP60_01420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ESP60_01435	COG4974	Belongs to the 'phage' integrase family
ESP60_01440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ESP60_01445	COG2204	response regulator
ESP60_01450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ESP60_01465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ESP60_01480	COG0546	phosphoglycolate phosphatase activity
ESP60_01490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ESP60_01490	COG0574	Belongs to the PEP-utilizing enzyme family
ESP60_01495	COG0651	ATP synthesis coupled electron transport
ESP60_01500	COG3474	cytochrome
ESP60_01525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ESP60_01535	COG0194	GDP metabolic process
ESP60_01540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESP60_01545	COG0632	four-way junction helicase activity
ESP60_01550	COG2255	four-way junction helicase activity
ESP60_01555	COG0752	glycyl-tRNA synthetase alpha subunit
ESP60_01565	COG2814	Major facilitator Superfamily
ESP60_01615	COG1132	(ABC) transporter
ESP60_01625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ESP60_01630	COG0359	binds to the 23S rRNA
ESP60_01635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ESP60_01640	COG0360	Binds together with S18 to 16S ribosomal RNA
ESP60_01680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ESP60_01685	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ESP60_01690	COG5000	phosphorelay sensor kinase activity
ESP60_01695	COG1278	Cold shock
ESP60_01725	COG0717	Belongs to the dCTP deaminase family
ESP60_01740	COG1612	heme a metabolic process
ESP60_01750	COG0124	histidyl-tRNA synthetase
ESP60_01755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ESP60_01780	COG4589	Belongs to the CDS family
ESP60_01785	COG0233	cytoplasmic translational termination
ESP60_01790	COG0528	UMP kinase activity
ESP60_01810	COG0307	riboflavin synthase, alpha
ESP60_01825	COG0612	Peptidase, M16
ESP60_01830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ESP60_01835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ESP60_01850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ESP60_01855	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ESP60_01870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ESP60_01875	COG0517	IMP dehydrogenase activity
ESP60_01875	COG0516	GMP reductase activity
ESP60_01880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ESP60_01900	COG2267	carboxylic ester hydrolase activity
ESP60_01905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ESP60_01915	COG3118	belongs to the thioredoxin family
ESP60_01920	COG1722	exodeoxyribonuclease VII activity
ESP60_01970	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ESP60_01970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ESP60_01995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ESP60_02000	COG0484	heat shock protein binding
ESP60_02005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP60_02010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ESP60_02020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ESP60_02025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ESP60_02035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ESP60_02045	COG0228	four-way junction DNA binding
ESP60_02055	COG2835	tetraacyldisaccharide 4'-kinase activity
ESP60_02060	COG1840	ABC-type Fe3 transport system, periplasmic component
ESP60_02080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ESP60_02090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ESP60_02100	COG0651	ATP synthesis coupled electron transport
ESP60_02110	COG0281	malic enzyme
ESP60_02110	COG0280	phosphate acetyltransferase
ESP60_02120	COG4974	Belongs to the 'phage' integrase family
ESP60_02130	COG0504	CTP synthase activity
ESP60_02135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ESP60_02135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ESP60_02140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ESP60_02145	COG0180	Tryptophanyl-tRNA synthetase
ESP60_02165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ESP60_02170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ESP60_02180	COG4695	Portal protein
ESP60_02190	COG1253	flavin adenine dinucleotide binding
ESP60_02200	COG1845	cytochrome c oxidase, subunit III
ESP60_02205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ESP60_02210	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ESP60_02215	COG0157	Belongs to the NadC ModD family
ESP60_02220	COG0484	heat shock protein binding
ESP60_02230	COG0752	glycyl-tRNA synthetase alpha subunit
ESP60_02245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ESP60_02255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ESP60_02260	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ESP60_02275	COG1127	ABC transporter
ESP60_02280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ESP60_02285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ESP60_02290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP60_02290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP60_02300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ESP60_02320	COG2948	multi-organism process
ESP60_02325	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ESP60_02330	COG3505	Type IV secretory pathway VirD4
ESP60_02360	COG1230	cation diffusion facilitator family transporter
ESP60_02425	COG0728	peptidoglycan biosynthetic process
ESP60_02430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ESP60_02445	COG0268	Binds directly to 16S ribosomal RNA
ESP60_02450	COG0204	Acyl-transferase
ESP60_02455	COG0242	peptide deformylase activity
ESP60_02475	COG0556	nucleotide-excision repair
ESP60_02480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESP60_02495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ESP60_02510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ESP60_02530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ESP60_02555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ESP60_02565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ESP60_02575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ESP60_02580	COG0670	Belongs to the BI1 family
ESP60_02585	COG0802	atpase or kinase
ESP60_02605	COG4591	ABC-type transport system involved in lipoprotein release permease component
ESP60_02625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESP60_02630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ESP60_02635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ESP60_02640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ESP60_02640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ESP60_02645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ESP60_02675	COG1138	Cytochrome C-type biogenesis protein
ESP60_02695	COG0372	Belongs to the citrate synthase family
ESP60_02700	COG0519	Catalyzes the synthesis of GMP from XMP
ESP60_02740	COG0776	regulation of translation
ESP60_02750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ESP60_02760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ESP60_02760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ESP60_02765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ESP60_02775	COG0012	GTP binding
ESP60_02790	COG0312	modulator of DNA gyrase
ESP60_02800	COG0022	dehydrogenase e1 component
ESP60_02805	COG1981	membrane
ESP60_02820	COG1040	competence protein
ESP60_02825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ESP60_02830	COG0193	aminoacyl-tRNA hydrolase activity
ESP60_02835	COG0193	aminoacyl-tRNA hydrolase activity
ESP60_02840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ESP60_02845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESP60_02850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ESP60_02855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ESP60_02860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ESP60_02890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ESP60_02895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ESP60_02915	COG0156	8-amino-7-oxononanoate synthase activity
ESP60_02920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ESP60_02930	COG0174	glutamine synthetase
ESP60_02935	COG0142	geranyltranstransferase activity
ESP60_02960	COG0552	protein localization to endoplasmic reticulum
ESP60_02965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ESP60_02980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ESP60_02985	COG0336	Belongs to the RNA methyltransferase TrmD family
ESP60_02995	COG1058	Belongs to the CinA family
ESP60_02995	COG1546	Belongs to the CinA family
ESP60_03005	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ESP60_03060	COG0500	methyltransferase
ESP60_03085	COG1570	exodeoxyribonuclease VII activity
ESP60_03105	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP60_03110	COG1830	Aldolase
ESP60_03130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ESP60_03150	COG1396	sequence-specific DNA binding
ESP60_03155	COG0105	UTP biosynthetic process
ESP60_03160	COG0617	tRNA 3'-terminal CCA addition
ESP60_03170	COG1686	Belongs to the peptidase S11 family
ESP60_03185	COG0750	zinc metalloprotease
ESP60_03190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ESP60_03200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ESP60_03205	COG0138	bifunctional purine biosynthesis protein purh
ESP60_03210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ESP60_03215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ESP60_03230	COG2890	protein-(glutamine-N5) methyltransferase activity
ESP60_03235	COG0024	Methionine aminopeptidase
ESP60_03240	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP60_03280	COG0356	it plays a direct role in the translocation of protons across the membrane
ESP60_03285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESP60_03315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ESP60_03315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ESP60_03320	COG0473	3-isopropylmalate dehydrogenase activity
ESP60_03340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ESP60_03345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ESP60_03375	COG0653	protein targeting
ESP60_03380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ESP60_03395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ESP60_03425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ESP60_03430	COG0196	riboflavin kinase activity
ESP60_03435	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ESP60_03455	COG3346	SURF1 family
ESP60_03495	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ESP60_03500	COG0571	ribonuclease III activity
ESP60_03510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESP60_03515	COG0330	HflC and HflK could
ESP60_03520	COG0330	HflC and HflK could
ESP60_03610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ESP60_03635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESP60_03645	COG0489	protein tyrosine kinase activity
ESP60_03650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ESP60_03670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ESP60_03675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ESP60_03685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ESP60_03695	COG0745	RESPONSE REGULATOR receiver
ESP60_03705	COG0592	DNA-directed DNA polymerase activity
ESP60_03710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ESP60_03720	COG1862	Preprotein translocase
ESP60_03730	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ESP60_03735	COG0109	protoheme IX farnesyltransferase activity
ESP60_03740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ESP60_03765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESP60_03780	COG2226	methyltransferase
ESP60_03785	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ESP60_03790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ESP60_03795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ESP60_03800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP60_03855	COG0573	inorganic phosphate transmembrane transporter activity
ESP60_03860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ESP60_03865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ESP60_03880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ESP60_03885	COG0045	succinate-CoA ligase (ADP-forming) activity
ESP60_03890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ESP60_03900	COG1999	signal sequence binding
ESP60_03920	COG1178	ABC-type Fe3 transport system permease component
ESP60_03945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ESP60_03950	COG0049	tRNA binding
ESP60_03955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ESP60_03960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ESP60_03975	COG0250	Participates in transcription elongation, termination and antitermination
ESP60_03980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ESP60_03985	COG0081	regulation of translation
ESP60_03990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ESP60_03995	COG0222	ribosome binding
ESP60_04000	COG0085	RNA polymerase activity
ESP60_04005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ESP60_04010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ESP60_04045	COG0156	8-amino-7-oxononanoate synthase activity
ESP60_04055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ESP60_04060	COG0167	dihydroorotate dehydrogenase activity
ESP60_04065	COG0242	peptide deformylase activity
ESP60_04070	COG0400	carboxylic ester hydrolase activity
ESP60_04075	COG0259	pyridoxamine-phosphate oxidase activity
ESP60_04100	COG2009	succinate dehydrogenase
ESP60_04105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ESP60_04115	COG0628	permease
ESP60_04125	COG0351	phosphomethylpyrimidine kinase
ESP60_04125	COG0352	thiamine-phosphate diphosphorylase activity
ESP60_04140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ESP60_04145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ESP60_04150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ESP60_04155	COG3842	ATPase activity
ESP60_04165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ESP60_04170	COG1121	(ABC) transporter
ESP60_04185	COG0156	8-amino-7-oxononanoate synthase activity
ESP60_04220	COG0544	peptidyl-prolyl cis-trans isomerase activity
ESP60_04225	COG0740	serine-type endopeptidase activity
ESP60_04230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ESP60_04235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ESP60_04245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ESP60_04250	COG1054	Belongs to the UPF0176 family
ESP60_04255	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ESP60_04260	COG0352	thiamine-phosphate diphosphorylase activity
ESP60_04265	COG4536	flavin adenine dinucleotide binding
ESP60_04275	COG1674	ftsk spoiiie
ESP60_04275	COG1674	ftsk spoiiie
ESP60_04295	COG0758	DNA mediated transformation
ESP60_04315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ESP60_04330	COG2205	protein histidine kinase activity
ESP60_04330	COG2202	Pas domain
ESP60_04335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ESP60_04350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ESP60_04355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ESP60_04365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESP60_04375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ESP60_04425	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ESP60_04435	COG0482	sulfurtransferase activity
ESP60_04460	COG0210	DNA helicase
ESP60_04480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ESP60_04495	COG0326	Molecular chaperone. Has ATPase activity
ESP60_04500	COG0322	excinuclease ABC activity
ESP60_04510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ESP60_04530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ESP60_04530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ESP60_04545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ESP60_04555	COG0567	Dehydrogenase, E1 component
ESP60_04575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ESP60_04590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ESP60_04590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ESP60_04595	COG0113	porphobilinogen synthase activity
ESP60_04640	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ESP60_04690	COG0302	gtp cyclohydrolase
ESP60_04735	COG0681	Belongs to the peptidase S26 family
ESP60_04740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESP60_04750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ESP60_04755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ESP60_04770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ESP60_04775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ESP60_04785	COG0470	DNA polymerase III
ESP60_04790	COG0009	L-threonylcarbamoyladenylate synthase
ESP60_04830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ESP60_04835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ESP60_04840	COG1185	polyribonucleotide nucleotidyltransferase activity
ESP60_04845	COG2226	methyltransferase
ESP60_04850	COG0481	GTPase activity
ESP60_04875	COG0606	chelatase, subunit chli
ESP60_04885	COG0163	prenyltransferase activity
ESP60_04890	COG0154	amidase activity
ESP60_04895	COG0285	dihydrofolate synthase activity
ESP60_04900	COG0181	hydroxymethylbilane synthase activity
ESP60_04905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ESP60_04935	COG1381	Involved in DNA repair and RecF pathway recombination
ESP60_04940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ESP60_04945	COG0492	ferredoxin-NADP+ reductase activity
ESP60_04950	COG0649	NAD binding
ESP60_04955	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ESP60_04960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ESP60_05000	COG0187	DNA topoisomerase II activity
ESP60_05010	COG1034	ATP synthesis coupled electron transport
ESP60_05015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ESP60_05030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ESP60_05035	COG0302	gtp cyclohydrolase
ESP60_05040	COG0312	modulator of DNA gyrase
ESP60_05050	COG0018	arginyl-trna synthetase
ESP60_05060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ESP60_05065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ESP60_05075	COG0148	phosphopyruvate hydratase activity
ESP60_05080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ESP60_05100	COG0275	rRNA processing
ESP60_05125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ESP60_05145	COG0443	Heat shock 70 kDa protein
ESP60_05150	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ESP60_05155	COG0316	Belongs to the HesB IscA family
ESP60_05160	COG0822	iron-sulfur transferase activity
ESP60_05165	COG1104	cysteine desulfurase activity
ESP60_05175	COG2945	thiolester hydrolase activity
ESP60_05205	COG0436	Aminotransferase
ESP60_05210	COG0450	alkyl hydroperoxide reductase
ESP60_05215	COG0492	ferredoxin-NADP+ reductase activity
ESP60_05235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ESP60_05255	COG0442	prolyl-tRNA aminoacylation
ESP60_05260	COG0736	holo-[acyl-carrier-protein] synthase activity
ESP60_05280	COG0698	ribose 5-phosphate isomerase
ESP60_05315	COG0039	L-malate dehydrogenase activity
ESP60_05330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ESP60_05335	COG2358	TRAP transporter, solute receptor (TAXI family
ESP60_05340	COG0149	triose-phosphate isomerase activity
ESP60_05350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ESP60_05400	COG1214	PFAM Peptidase M22, glycoprotease
ESP60_05410	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ESP60_05415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ESP60_05430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ESP60_05430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ESP60_05440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ESP60_05445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ESP60_05465	COG1324	tolerance protein
ESP60_05475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ESP60_05480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ESP60_05485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ESP60_05500	COG0358	DNA primase activity
ESP60_05530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP60_05535	COG0215	cysteine-tRNA ligase activity
ESP60_05540	COG3932	Exopolysaccharide synthesis, ExoD
ESP60_05560	COG0564	pseudouridine synthase activity
ESP60_05565	COG0483	inositol monophosphate 1-phosphatase activity
ESP60_05570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ESP60_05580	COG0493	'glutamate synthase
ESP60_05580	COG0543	2 iron, 2 sulfur cluster binding
ESP60_05585	COG0688	phosphatidylethanolamine metabolic process
ESP60_05590	COG1183	phosphatidylcholine synthase activity
ESP60_05595	COG1034	ATP synthesis coupled electron transport
ESP60_05605	COG0706	membrane insertase activity