locus-tag	class	description
GUI12_00005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GUI12_00025	COG0242	peptide deformylase activity
GUI12_00065	COG0284	orotidine-5'-phosphate decarboxylase activity
GUI12_00075	COG0268	Binds directly to 16S ribosomal RNA
GUI12_00080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GUI12_00090	COG1192	Involved in chromosome partitioning
GUI12_00095	COG1475	DNA binding
GUI12_00105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GUI12_00110	COG1840	ABC-type Fe3 transport system, periplasmic component
GUI12_00135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GUI12_00155	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GUI12_00160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GUI12_00175	COG0307	riboflavin synthase, alpha
GUI12_00180	COG0653	protein targeting
GUI12_00185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GUI12_00195	COG0839	Belongs to the complex I subunit 6 family
GUI12_00200	COG0312	modulator of DNA gyrase
GUI12_00205	COG0302	gtp cyclohydrolase
GUI12_00210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GUI12_00225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GUI12_00235	COG0101	tRNA pseudouridine synthase activity
GUI12_00240	COG0328	RNA-DNA hybrid ribonuclease activity
GUI12_00245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GUI12_00250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GUI12_00255	COG0745	RESPONSE REGULATOR receiver
GUI12_00265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GUI12_00275	COG0730	response to heat
GUI12_00290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GUI12_00315	COG0113	porphobilinogen synthase activity
GUI12_00340	COG4695	Portal protein
GUI12_00345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GUI12_00350	COG0629	single-stranded DNA binding
GUI12_00355	COG0482	sulfurtransferase activity
GUI12_00370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GUI12_00375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GUI12_00380	COG0706	membrane insertase activity
GUI12_00395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GUI12_00410	COG0360	Binds together with S18 to 16S ribosomal RNA
GUI12_00420	COG0359	binds to the 23S rRNA
GUI12_00425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GUI12_00435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GUI12_00435	COG0475	glutathione-regulated potassium exporter activity
GUI12_00445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GUI12_00465	COG0768	penicillin binding
GUI12_00470	COG4133	protoheme IX ABC transporter activity
GUI12_00475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GUI12_00525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GUI12_00530	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GUI12_00535	COG2856	Zn peptidase
GUI12_00550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GUI12_00560	COG0698	ribose 5-phosphate isomerase
GUI12_00565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GUI12_00590	COG0138	bifunctional purine biosynthesis protein purh
GUI12_00610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GUI12_00615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GUI12_00615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GUI12_00625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GUI12_00635	COG0590	tRNA wobble adenosine to inosine editing
GUI12_00640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GUI12_00650	COG0167	dihydroorotate dehydrogenase activity
GUI12_00670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GUI12_00670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GUI12_00675	COG1830	Aldolase
GUI12_00680	COG0628	permease
GUI12_00690	COG1686	Belongs to the peptidase S11 family
GUI12_00695	COG3474	cytochrome
GUI12_00700	COG1472	Belongs to the glycosyl hydrolase 3 family
GUI12_00720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GUI12_00725	COG1178	ABC-type Fe3 transport system permease component
GUI12_00730	COG0037	tRNA processing
GUI12_00735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GUI12_00740	COG0805	protein transport
GUI12_00745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GUI12_00745	COG2890	protein-(glutamine-N5) methyltransferase activity
GUI12_00750	COG0443	Heat shock 70 kDa protein
GUI12_00755	COG1530	ribonuclease E activity
GUI12_00780	COG0508	dehydrogenase complex catalyzes the overall conversion of
GUI12_00785	COG0756	dUTP diphosphatase activity
GUI12_00790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUI12_00800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GUI12_00805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GUI12_00815	COG1684	flagellar biosynthetic protein fliR
GUI12_00830	COG0495	leucyl-tRNA aminoacylation
GUI12_00835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GUI12_00840	COG0525	valine-tRNA ligase activity
GUI12_00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GUI12_00910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GUI12_00915	COG1674	ftsk spoiiie
GUI12_00920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GUI12_00930	COG4591	ABC-type transport system involved in lipoprotein release permease component
GUI12_00935	COG3300	MHYT domain
GUI12_00935	COG5001	Diguanylate cyclase
GUI12_00940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GUI12_00940	COG2111	Na H antiporter
GUI12_00945	COG0723	plastoquinol--plastocyanin reductase activity
GUI12_00950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GUI12_00960	COG2267	carboxylic ester hydrolase activity
GUI12_00965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GUI12_00995	COG0372	Belongs to the citrate synthase family
GUI12_01015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GUI12_01020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GUI12_01025	COG4770	biotin carboxylase activity
GUI12_01030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GUI12_01050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GUI12_01055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GUI12_01080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GUI12_01110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GUI12_01115	COG1396	sequence-specific DNA binding
GUI12_01125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GUI12_01125	COG0574	Belongs to the PEP-utilizing enzyme family
GUI12_01140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GUI12_01150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GUI12_01170	COG0124	histidyl-tRNA synthetase
GUI12_01180	COG0477	Major facilitator Superfamily
GUI12_01195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUI12_01200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUI12_01205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUI12_01215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUI12_01225	COG2009	succinate dehydrogenase
GUI12_01235	COG0018	arginyl-trna synthetase
GUI12_01240	COG0196	riboflavin kinase activity
GUI12_01265	COG1573	uracil-dna glycosylase
GUI12_01285	COG0484	heat shock protein binding
GUI12_01295	COG0181	hydroxymethylbilane synthase activity
GUI12_01310	COG0505	Belongs to the CarA family
GUI12_01320	COG1051	belongs to the nudix hydrolase family
GUI12_01335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GUI12_01340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GUI12_01345	COG1766	The M ring may be actively involved in energy transduction
GUI12_01350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GUI12_01375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GUI12_01385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GUI12_01410	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GUI12_01420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GUI12_01425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GUI12_01430	COG2945	thiolester hydrolase activity
GUI12_01435	COG1104	cysteine desulfurase activity
GUI12_01440	COG1104	cysteine desulfurase activity
GUI12_01445	COG0822	iron-sulfur transferase activity
GUI12_01450	COG0316	Belongs to the HesB IscA family
GUI12_01455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GUI12_01460	COG0443	Heat shock 70 kDa protein
GUI12_01470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GUI12_01475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GUI12_01485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GUI12_01495	COG0012	GTP binding
GUI12_01500	COG0445	tRNA wobble uridine modification
GUI12_01510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GUI12_01550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GUI12_01555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GUI12_01560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GUI12_01560	COG0519	Catalyzes the synthesis of GMP from XMP
GUI12_01575	COG4786	Flagellar basal body rod
GUI12_01580	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GUI12_01605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GUI12_01615	COG0527	aspartate kinase activity
GUI12_01620	COG0492	ferredoxin-NADP+ reductase activity
GUI12_01625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GUI12_01630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GUI12_01635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GUI12_01640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GUI12_01720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GUI12_01730	COG0746	molybdenum cofactor guanylyltransferase activity
GUI12_01735	COG0314	molybdopterin synthase activity
GUI12_01745	COG0303	'Molybdopterin
GUI12_01750	COG0315	cyclic pyranopterin monophosphate synthase activity
GUI12_01750	COG0521	Mo-molybdopterin cofactor biosynthetic process
GUI12_01755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GUI12_01765	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GUI12_01770	COG1140	nitrate reductase beta subunit
GUI12_01775	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GUI12_01780	COG2181	nitrate reductase activity
GUI12_01805	COG2816	NAD+ diphosphatase activity
GUI12_01815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GUI12_01835	COG0697	spore germination
GUI12_01865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GUI12_01875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GUI12_01880	COG1185	polyribonucleotide nucleotidyltransferase activity
GUI12_01885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GUI12_01900	COG0592	DNA-directed DNA polymerase activity
GUI12_01905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GUI12_01950	COG0442	prolyl-tRNA aminoacylation
GUI12_01975	COG0312	modulator of DNA gyrase
GUI12_01990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GUI12_02000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GUI12_02005	COG0481	GTPase activity
GUI12_02030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GUI12_02045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GUI12_02065	COG0612	Peptidase, M16
GUI12_02070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GUI12_02080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GUI12_02090	COG0335	large ribosomal subunit rRNA binding
GUI12_02100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GUI12_02105	COG0228	four-way junction DNA binding
GUI12_02110	COG0792	nuclease activity
GUI12_02115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GUI12_02120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GUI12_02125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GUI12_02140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GUI12_02150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GUI12_02150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GUI12_02155	COG0305	Participates in initiation and elongation during chromosome replication
GUI12_02160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GUI12_02165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GUI12_02170	COG0237	dephospho-CoA kinase activity
GUI12_02175	COG0516	GMP reductase activity
GUI12_02175	COG0517	IMP dehydrogenase activity
GUI12_02185	COG1121	(ABC) transporter
GUI12_02210	COG1494	fructose-1,6-bisphosphatase
GUI12_02215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GUI12_02225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GUI12_02240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GUI12_02255	COG0051	transcription antitermination factor activity, RNA binding
GUI12_02260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GUI12_02265	COG0088	Forms part of the polypeptide exit tunnel
GUI12_02275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GUI12_02280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GUI12_02285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GUI12_02290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GUI12_02295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GUI12_02305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GUI12_02315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GUI12_02320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GUI12_02325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GUI12_02330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GUI12_02335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GUI12_02340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GUI12_02345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GUI12_02355	COG0201	protein transport
GUI12_02360	COG0563	adenylate kinase activity
GUI12_02370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GUI12_02375	COG0202	RNA polymerase activity
GUI12_02380	COG0203	ribosomal protein L17
GUI12_02455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GUI12_02465	COG0552	protein localization to endoplasmic reticulum
GUI12_02525	COG0504	CTP synthase activity
GUI12_02530	COG1845	cytochrome c oxidase, subunit III
GUI12_02540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GUI12_02545	COG2271	Major facilitator Superfamily
GUI12_02550	COG2211	Major facilitator Superfamily
GUI12_02560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GUI12_02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
GUI12_02575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GUI12_02580	COG0174	glutamine synthetase
GUI12_02585	COG0537	adenosine 5'-monophosphoramidase activity
GUI12_02605	COG0215	cysteine-tRNA ligase activity
GUI12_02615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GUI12_02625	COG0084	hydrolase, TatD family'
GUI12_02630	COG2171	N-acyltransferase activity
GUI12_02635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GUI12_02640	COG1999	signal sequence binding
GUI12_02645	COG0489	protein tyrosine kinase activity
GUI12_02650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GUI12_02660	COG1007	ATP synthesis coupled electron transport
GUI12_02675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GUI12_02680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GUI12_02695	COG2226	methyltransferase
GUI12_02710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GUI12_02720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GUI12_02735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GUI12_02745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GUI12_02755	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GUI12_02760	COG0540	Belongs to the ATCase OTCase family
GUI12_02765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GUI12_02780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GUI12_02785	COG1136	(ABC) transporter
GUI12_02795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GUI12_02800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GUI12_02815	COG0493	'glutamate synthase
GUI12_02815	COG0543	2 iron, 2 sulfur cluster binding
GUI12_02830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GUI12_02845	COG0493	'glutamate synthase
GUI12_02845	COG0543	2 iron, 2 sulfur cluster binding
GUI12_02850	COG1187	pseudouridine synthase activity
GUI12_02870	COG0330	HflC and HflK could
GUI12_02920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GUI12_02925	COG0148	phosphopyruvate hydratase activity
GUI12_02930	COG0617	tRNA 3'-terminal CCA addition
GUI12_02940	COG0564	pseudouridine synthase activity
GUI12_02945	COG0492	ferredoxin-NADP+ reductase activity
GUI12_02950	COG0450	alkyl hydroperoxide reductase
GUI12_02965	COG0194	GDP metabolic process
GUI12_02975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GUI12_02980	COG0006	proline dipeptidase activity
GUI12_02985	COG1612	heme a metabolic process
GUI12_02990	COG0708	Exodeoxyribonuclease III
GUI12_03005	COG1253	flavin adenine dinucleotide binding
GUI12_03010	COG5265	(ABC) transporter
GUI12_03015	COG0473	3-isopropylmalate dehydrogenase activity
GUI12_03030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GUI12_03035	COG0740	serine-type endopeptidase activity
GUI12_03040	COG0544	peptidyl-prolyl cis-trans isomerase activity
GUI12_03065	COG0022	dehydrogenase e1 component
GUI12_03075	COG0126	phosphoglycerate kinase activity
GUI12_03080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GUI12_03085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GUI12_03095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GUI12_03110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GUI12_03110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GUI12_03115	COG0823	Involved in the tonB-independent uptake of proteins
GUI12_03120	COG0681	Belongs to the peptidase S26 family
GUI12_03130	COG1138	Cytochrome C-type biogenesis protein
GUI12_03135	COG4589	Belongs to the CDS family
GUI12_03140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GUI12_03150	COG0528	UMP kinase activity
GUI12_03160	COG0052	Belongs to the universal ribosomal protein uS2 family
GUI12_03165	COG0508	dehydrogenase complex catalyzes the overall conversion of
GUI12_03170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GUI12_03190	COG0772	Belongs to the SEDS family
GUI12_03195	COG0105	UTP biosynthetic process
GUI12_03200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GUI12_03210	COG0326	Molecular chaperone. Has ATPase activity
GUI12_03215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GUI12_03230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GUI12_03230	COG3266	domain, Protein
GUI12_03240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GUI12_03250	COG0156	8-amino-7-oxononanoate synthase activity
GUI12_03265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GUI12_03270	COG2902	Dehydrogenase
GUI12_03295	COG1338	Plays a role in the flagellum-specific transport system
GUI12_03325	COG0180	Tryptophanyl-tRNA synthetase
GUI12_03330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GUI12_03345	COG2867	negative regulation of translational initiation
GUI12_03350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GUI12_03360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GUI12_03375	COG4786	Flagellar basal body rod
GUI12_03395	COG0210	DNA helicase
GUI12_03400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GUI12_03405	COG0085	RNA polymerase activity
GUI12_03420	COG0081	regulation of translation
GUI12_03425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GUI12_03440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GUI12_03445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GUI12_03450	COG0049	tRNA binding
GUI12_03455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GUI12_03465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GUI12_03475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GUI12_03490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GUI12_03505	COG0728	peptidoglycan biosynthetic process
GUI12_03515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GUI12_03520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GUI12_03525	COG1968	undecaprenyl-diphosphatase activity
GUI12_03530	COG0751	glycine-tRNA ligase activity
GUI12_03535	COG0752	glycyl-tRNA synthetase alpha subunit
GUI12_03555	COG1217	gtp-binding protein TYPA
GUI12_03560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GUI12_03565	COG0154	amidase activity
GUI12_03570	COG1054	Belongs to the UPF0176 family
GUI12_03575	COG4974	Belongs to the 'phage' integrase family
GUI12_03580	COG0281	malic enzyme
GUI12_03580	COG0280	phosphate acetyltransferase
GUI12_03585	COG3842	ATPase activity
GUI12_03590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GUI12_03615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GUI12_03620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GUI12_03625	COG0151	Belongs to the GarS family
GUI12_03635	COG0758	DNA mediated transformation
GUI12_03645	COG1090	epimerase
GUI12_03665	COG0024	Methionine aminopeptidase
GUI12_03670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GUI12_03695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GUI12_03715	COG0606	chelatase, subunit chli
GUI12_03725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GUI12_03730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GUI12_03740	COG1360	Flagellar Motor Protein
GUI12_03755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GUI12_03770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GUI12_03780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GUI12_03790	COG0045	succinate-CoA ligase (ADP-forming) activity
GUI12_03810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GUI12_03820	COG0670	Belongs to the BI1 family
GUI12_03825	COG0739	heme binding
GUI12_03835	COG1438	arginine binding
GUI12_03840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GUI12_03845	COG0765	amino acid transport
GUI12_03865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GUI12_03870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GUI12_03890	COG1183	phosphatidylcholine synthase activity
GUI12_03895	COG0688	phosphatidylethanolamine metabolic process
GUI12_03905	COG0697	spore germination
GUI12_03910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GUI12_03920	COG2814	Major facilitator Superfamily
GUI12_03940	COG0799	negative regulation of ribosome biogenesis
GUI12_03965	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
GUI12_03980	COG3736	Type IV secretory pathway, component VirB8
GUI12_03985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GUI12_04000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GUI12_04010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GUI12_04025	COG1686	Belongs to the peptidase S11 family
GUI12_04030	COG0632	four-way junction helicase activity
GUI12_04060	COG2255	four-way junction helicase activity
GUI12_04065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GUI12_04070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GUI12_04080	COG0668	transmembrane transport
GUI12_04085	COG1706	bacterial-type flagellum-dependent cell motility
GUI12_04090	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GUI12_04100	COG0285	dihydrofolate synthase activity
GUI12_04110	COG1028	Short-chain dehydrogenase reductase Sdr
GUI12_04115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GUI12_04120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GUI12_04130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GUI12_04145	COG1294	oxidase, subunit
GUI12_04150	COG1271	oxidase subunit
GUI12_04165	COG1301	dicarboxylic acid transport
GUI12_04175	COG0235	Class ii aldolase
GUI12_04190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GUI12_04195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GUI12_04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GUI12_04265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GUI12_04275	COG0321	lipoyl(octanoyl) transferase activity
GUI12_04280	COG0564	pseudouridine synthase activity
GUI12_04285	COG0793	Belongs to the peptidase S41A family
GUI12_04315	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GUI12_04330	COG0848	biopolymer transport protein
GUI12_04335	COG0811	peptide transport
GUI12_04340	COG0581	inorganic phosphate transmembrane transporter activity
GUI12_04345	COG0072	phenylalanine-tRNA ligase activity
GUI12_04345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GUI12_04395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GUI12_04410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GUI12_04415	COG0649	NAD binding
GUI12_04420	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GUI12_04440	COG2239	Acts as a magnesium transporter
GUI12_04450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GUI12_04460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GUI12_04470	COG2070	2-Nitropropane dioxygenase
GUI12_04475	COG1862	Preprotein translocase
GUI12_04480	COG0358	DNA primase activity
GUI12_04485	COG0736	holo-[acyl-carrier-protein] synthase activity
GUI12_04495	COG1053	succinate dehydrogenase
GUI12_04510	COG0047	phosphoribosylformylglycinamidine synthase activity
GUI12_04550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GUI12_04560	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUI12_04565	COG1007	ATP synthesis coupled electron transport
GUI12_04570	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GUI12_04570	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GUI12_04575	COG0142	geranyltranstransferase activity
GUI12_04595	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GUI12_04605	COG1981	membrane
GUI12_04620	COG0217	transcriptional regulatory protein
GUI12_04640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GUI12_04650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GUI12_04660	COG3704	protein secretion by the type IV secretion system
GUI12_04665	COG3704	protein secretion by the type IV secretion system
GUI12_04675	COG3704	protein secretion by the type IV secretion system
GUI12_04685	COG0419	ATPase involved in DNA repair
GUI12_04685	COG3704	protein secretion by the type IV secretion system
GUI12_04690	COG3451	type IV secretory pathway VirB4