locus-tag	class	description
CB4_00001	COG3829	transcription factor binding
CB4_00002	COG1509	lysine 2,3-aminomutase activity
CB4_00004	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_00007	COG2323	membrane
CB4_00012	COG2814	Major facilitator Superfamily
CB4_00014	COG3973	AAA domain
CB4_00017	COG0726	polysaccharide deacetylase
CB4_00018	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_00032	COG5002	protein histidine kinase activity
CB4_00033	COG0745	RESPONSE REGULATOR receiver
CB4_00035	COG0735	belongs to the Fur family
CB4_00036	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CB4_00037	COG1121	(ABC) transporter
CB4_00039	COG2217	Heavy metal translocating P-type atpase
CB4_00040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CB4_00041	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CB4_00045	COG3829	transcription factor binding
CB4_00045	COG3290	protein histidine kinase activity
CB4_00048	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CB4_00049	COG0477	Major facilitator Superfamily
CB4_00051	COG1592	Rubrerythrin
CB4_00052	COG0531	amino acid
CB4_00053	COG0531	amino acid
CB4_00054	COG2116	formate transmembrane transporter activity
CB4_00056	COG3383	formate dehydrogenase (NAD+) activity
CB4_00058	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CB4_00059	COG4977	sequence-specific DNA binding
CB4_00059	COG1917	Cupin 2, conserved barrel domain protein
CB4_00061	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CB4_00075	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CB4_00076	COG1024	Enoyl-CoA hydratase
CB4_00077	COG0288	reversible hydration of carbon dioxide
CB4_00079	COG5002	protein histidine kinase activity
CB4_00081	COG0778	Nitroreductase
CB4_00083	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CB4_00085	COG4149	molybdate abc transporter
CB4_00086	COG0725	ABC transporter, periplasmic molybdate-binding protein
CB4_00087	COG1910	domain protein
CB4_00088	COG0442	prolyl-tRNA aminoacylation
CB4_00089	COG0626	cystathionine gamma-synthase activity
CB4_00090	COG0626	cystathionine gamma-synthase activity
CB4_00093	COG1113	amino acid transport
CB4_00094	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_00094	COG2199	diguanylate cyclase activity
CB4_00096	COG1704	LemA family
CB4_00098	COG2986	histidine ammonia-lyase
CB4_00099	COG0477	Major facilitator Superfamily
CB4_00100	COG0010	Belongs to the arginase family
CB4_00101	COG1228	amidohydrolase
CB4_00103	COG3279	Response regulator of the LytR AlgR family
CB4_00105	COG0833	amino acid
CB4_00106	COG2986	histidine ammonia-lyase
CB4_00110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_00115	COG0109	protoheme IX farnesyltransferase activity
CB4_00116	COG5278	phosphoserine phosphatase activity
CB4_00116	COG0840	transmembrane signaling receptor activity
CB4_00119	COG1846	Transcriptional regulator
CB4_00121	COG0702	epimerase
CB4_00122	COG2318	DinB family
CB4_00124	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CB4_00125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CB4_00126	COG4856	YbbR-like protein
CB4_00127	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CB4_00129	COG5662	AntiSigma factor
CB4_00130	COG1595	DNA-templated transcription, initiation
CB4_00131	COG0010	Belongs to the arginase family
CB4_00152	COG0726	polysaccharide deacetylase
CB4_00154	COG0489	protein tyrosine kinase activity
CB4_00155	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_00157	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CB4_00158	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CB4_00159	COG0514	ATP-dependent DNA helicase (RecQ)
CB4_00160	COG4585	Histidine kinase
CB4_00161	COG0840	transmembrane signaling receptor activity
CB4_00163	COG0101	tRNA pseudouridine synthase activity
CB4_00165	COG1122	ATPase activity
CB4_00166	COG1122	ATPase activity
CB4_00167	COG0203	ribosomal protein L17
CB4_00168	COG0202	RNA polymerase activity
CB4_00169	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CB4_00170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CB4_00171	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CB4_00172	COG0024	Methionine aminopeptidase
CB4_00173	COG0563	adenylate kinase activity
CB4_00174	COG0201	protein transport
CB4_00175	COG0200	Binds to the 23S rRNA
CB4_00176	COG1841	ribosomal large subunit assembly
CB4_00177	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CB4_00178	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CB4_00179	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CB4_00180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CB4_00181	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CB4_00182	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CB4_00183	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CB4_00184	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CB4_00185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CB4_00186	COG0255	Belongs to the universal ribosomal protein uL29 family
CB4_00187	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CB4_00188	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CB4_00189	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CB4_00190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CB4_00191	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CB4_00192	COG0089	rRNA binding
CB4_00193	COG0088	Forms part of the polypeptide exit tunnel
CB4_00194	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CB4_00195	COG0051	transcription antitermination factor activity, RNA binding
CB4_00201	COG2199	diguanylate cyclase activity
CB4_00201	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_00206	COG0789	Transcriptional regulator
CB4_00222	COG0704	Plays a role in the regulation of phosphate uptake
CB4_00223	COG0772	Belongs to the SEDS family
CB4_00224	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CB4_00226	COG0049	tRNA binding
CB4_00227	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CB4_00228	COG1358	cellular component organization or biogenesis
CB4_00229	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CB4_00230	COG0085	RNA polymerase activity
CB4_00231	COG2813	Specifically methylates the guanine in position
CB4_00232	COG0222	ribosome binding
CB4_00233	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CB4_00234	COG0081	regulation of translation
CB4_00236	COG0250	Participates in transcription elongation, termination and antitermination
CB4_00237	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CB4_00238	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CB4_00241	COG3688	RNA-binding protein containing a PIN domain
CB4_00242	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CB4_00244	COG0215	cysteine-tRNA ligase activity
CB4_00245	COG1045	serine acetyltransferase
CB4_00246	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CB4_00247	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CB4_00249	COG4956	integral membrane protein (PIN domain superfamily)
CB4_00250	COG1329	Transcriptional regulator
CB4_00251	COG1183	phosphatidylcholine synthase activity
CB4_00252	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CB4_00253	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CB4_00254	COG0542	response to heat
CB4_00255	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CB4_00256	COG3880	PFAM UvrB UvrC protein
CB4_00257	COG4463	regulation of RNA biosynthetic process
CB4_00258	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CB4_00259	COG0581	inorganic phosphate transmembrane transporter activity
CB4_00260	COG0573	inorganic phosphate transmembrane transporter activity
CB4_00262	COG0840	transmembrane signaling receptor activity
CB4_00268	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CB4_00270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CB4_00271	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CB4_00272	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CB4_00273	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CB4_00274	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CB4_00275	COG0512	Glutamine amidotransferase of anthranilate synthase
CB4_00276	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CB4_00277	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CB4_00279	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CB4_00281	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CB4_00282	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CB4_00283	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CB4_00285	COG0037	tRNA processing
CB4_00288	COG2208	phosphoserine phosphatase activity
CB4_00289	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CB4_00292	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CB4_00293	COG3956	TIGRFAM MazG family protein
CB4_00294	COG2244	polysaccharide biosynthetic process
CB4_00295	COG2002	toxin-antitoxin pair type II binding
CB4_00297	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CB4_00299	COG0193	aminoacyl-tRNA hydrolase activity
CB4_00300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CB4_00301	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CB4_00302	COG2088	sporulation resulting in formation of a cellular spore
CB4_00303	COG0251	oxidation-reduction process
CB4_00304	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CB4_00305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CB4_00307	COG4466	Protein conserved in bacteria
CB4_00309	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CB4_00311	COG3584	3D domain protein
CB4_00311	COG1388	LysM domain
CB4_00312	COG0084	hydrolase, TatD family'
CB4_00314	COG2002	toxin-antitoxin pair type II binding
CB4_00316	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CB4_00317	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CB4_00318	COG4467	Involved in initiation control of chromosome replication
CB4_00319	COG1774	PSP1 C-terminal conserved region
CB4_00320	COG0470	DNA polymerase III
CB4_00321	COG1728	Protein conserved in bacteria
CB4_00322	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CB4_00323	COG1982	Orn Lys Arg decarboxylase major
CB4_00331	COG1266	CAAX protease self-immunity
CB4_00332	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CB4_00333	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CB4_00334	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CB4_00335	COG5002	protein histidine kinase activity
CB4_00340	COG1309	transcriptional regulator
CB4_00341	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB4_00343	COG0590	tRNA wobble adenosine to inosine editing
CB4_00346	COG2267	carboxylic ester hydrolase activity
CB4_00348	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_00349	COG1024	Enoyl-CoA hydratase
CB4_00350	COG3829	transcription factor binding
CB4_00350	COG3290	protein histidine kinase activity
CB4_00354	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CB4_00354	COG1587	Uroporphyrinogen-III synthase
CB4_00360	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CB4_00365	COG2197	response regulator
CB4_00366	COG4585	Histidine kinase
CB4_00369	COG0427	acetyl-CoA hydrolase
CB4_00370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CB4_00372	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CB4_00374	COG0516	GMP reductase activity
CB4_00374	COG0517	IMP dehydrogenase activity
CB4_00379	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CB4_00380	COG0187	DNA topoisomerase II activity
CB4_00382	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CB4_00383	COG2501	S4 domain
CB4_00384	COG0592	DNA-directed DNA polymerase activity
CB4_00385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CB4_00387	COG0706	membrane insertase activity
CB4_00388	COG1847	R3H domain protein
CB4_00389	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CB4_00390	COG0445	tRNA wobble uridine modification
CB4_00391	COG0357	Ribosomal RNA small subunit methyltransferase G
CB4_00392	COG1475	DNA binding
CB4_00393	COG1192	Involved in chromosome partitioning
CB4_00394	COG1475	DNA binding
CB4_00399	COG0668	transmembrane transport
CB4_00400	COG4481	Protein conserved in bacteria
CB4_00402	COG0012	GTP binding
CB4_00404	COG0629	single-stranded DNA binding
CB4_00405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CB4_00407	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CB4_00408	COG0359	binds to the 23S rRNA
CB4_00409	COG1372	Participates in initiation and elongation during chromosome replication
CB4_00409	COG0305	Participates in initiation and elongation during chromosome replication
CB4_00410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CB4_00411	COG0739	heme binding
CB4_00412	COG0745	RESPONSE REGULATOR receiver
CB4_00413	COG5002	protein histidine kinase activity
CB4_00414	COG4863	YycH protein
CB4_00415	COG4853	Protein conserved in bacteria
CB4_00416	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CB4_00417	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB4_00419	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CB4_00421	COG4221	oxidoreductase activity
CB4_00422	COG1063	alcohol dehydrogenase
CB4_00424	COG4221	oxidoreductase activity
CB4_00426	COG2972	Histidine kinase
CB4_00426	COG0745	RESPONSE REGULATOR receiver
CB4_00427	COG3693	PFAM glycoside hydrolase, family 10
CB4_00429	COG0697	spore germination
CB4_00433	COG1595	DNA-templated transcription, initiation
CB4_00436	COG0840	transmembrane signaling receptor activity
CB4_00437	COG0697	spore germination
CB4_00438	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_00440	COG1346	cytolysis
CB4_00441	COG1380	Effector of murein hydrolase LrgA
CB4_00442	COG0583	DNA-binding transcription factor activity
CB4_00448	COG5002	protein histidine kinase activity
CB4_00450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CB4_00452	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CB4_00453	COG0583	DNA-binding transcription factor activity
CB4_00455	COG4895	conserved protein (DUF2196)
CB4_00457	COG1643	Atp-dependent helicase
CB4_00458	COG2322	membrane
CB4_00460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CB4_00461	COG1845	cytochrome c oxidase, subunit III
CB4_00463	COG2186	Transcriptional regulator
CB4_00465	COG0559	Belongs to the binding-protein-dependent transport system permease family
CB4_00469	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CB4_00470	COG0037	tRNA processing
CB4_00471	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CB4_00472	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CB4_00474	COG0702	epimerase
CB4_00475	COG1801	Protein of unknown function DUF72
CB4_00476	COG0351	phosphomethylpyrimidine kinase
CB4_00477	COG0840	transmembrane signaling receptor activity
CB4_00478	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CB4_00479	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CB4_00479	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CB4_00480	COG0450	alkyl hydroperoxide reductase
CB4_00481	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CB4_00482	COG0531	amino acid
CB4_00500	COG3853	Toxic anion resistance protein (TelA)
CB4_00501	COG2094	Belongs to the DNA glycosylase MPG family
CB4_00506	COG1151	hydroxylamine reductase activity
CB4_00510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CB4_00514	COG5001	Diguanylate cyclase
CB4_00514	COG3300	MHYT domain
CB4_00516	COG1192	Involved in chromosome partitioning
CB4_00518	COG4841	protein insertion into membrane
CB4_00519	COG0697	spore germination
CB4_00521	COG1131	(ABC) transporter
CB4_00525	COG2363	Small membrane protein
CB4_00528	COG1295	ribonuclease BN
CB4_00530	COG0726	polysaccharide deacetylase
CB4_00530	COG1649	PFAM Uncharacterised BCR, COG1649
CB4_00532	COG1131	(ABC) transporter
CB4_00533	COG4473	ABC transporter
CB4_00534	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CB4_00536	COG0584	glycerophosphoryl diester phosphodiesterase
CB4_00537	COG1114	Component of the transport system for branched-chain amino acids
CB4_00538	COG0367	asparagine synthase
CB4_00540	COG4844	belongs to the
CB4_00542	COG0564	pseudouridine synthase activity
CB4_00543	COG1078	dGTPase activity
CB4_00545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CB4_00547	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CB4_00548	COG0010	Belongs to the arginase family
CB4_00550	COG0018	arginyl-trna synthetase
CB4_00552	COG2181	nitrate reductase activity
CB4_00552	COG0247	lactate metabolic process
CB4_00553	COG0183	Belongs to the thiolase family
CB4_00554	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_00555	COG1960	acyl-CoA dehydrogenase activity
CB4_00556	COG1960	acyl-CoA dehydrogenase activity
CB4_00557	COG1703	isobutyryl-CoA mutase activity
CB4_00559	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CB4_00559	COG1703	isobutyryl-CoA mutase activity
CB4_00559	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CB4_00560	COG3343	RNA polymerase activity
CB4_00562	COG2204	response regulator
CB4_00563	COG0191	fructose-bisphosphate aldolase activity
CB4_00564	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CB4_00565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CB4_00566	COG1494	fructose-1,6-bisphosphatase
CB4_00567	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CB4_00569	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CB4_00571	COG0254	rRNA binding
CB4_00574	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CB4_00575	COG2890	protein-(glutamine-N5) methyltransferase activity
CB4_00577	COG0009	L-threonylcarbamoyladenylate synthase
CB4_00578	COG1971	Probably functions as a manganese efflux pump
CB4_00580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CB4_00582	COG0698	ribose 5-phosphate isomerase
CB4_00583	COG4475	Protein of unknown function (DUF436)
CB4_00584	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CB4_00585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CB4_00586	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CB4_00591	COG0356	it plays a direct role in the translocation of protons across the membrane
CB4_00593	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CB4_00594	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CB4_00595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CB4_00596	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CB4_00597	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CB4_00598	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CB4_00599	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CB4_00600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB4_00602	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB4_00603	COG0649	NAD binding
CB4_00604	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CB4_00608	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CB4_00609	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB4_00610	COG1007	ATP synthesis coupled electron transport
CB4_00611	COG4836	Membrane
CB4_00613	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CB4_00614	COG2385	sporulation resulting in formation of a cellular spore
CB4_00616	COG0739	heme binding
CB4_00617	COG1609	Transcriptional regulator
CB4_00619	COG4786	Flagellar basal body rod
CB4_00622	COG1522	sequence-specific DNA binding
CB4_00623	COG0436	Aminotransferase
CB4_00625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CB4_00628	COG1682	transport, permease protein
CB4_00630	COG2226	methyltransferase
CB4_00638	COG0463	Glycosyl transferase, family 2
CB4_00640	COG3246	L-lysine catabolic process to acetate
CB4_00642	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CB4_00643	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CB4_00647	COG1091	dTDP-4-dehydrorhamnose reductase activity
CB4_00648	COG1215	transferase activity, transferring glycosyl groups
CB4_00649	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CB4_00655	COG1846	Transcriptional regulator
CB4_00656	COG1566	PFAM secretion protein HlyD family protein
CB4_00657	COG2814	Major facilitator Superfamily
CB4_00658	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB4_00669	COG0793	Belongs to the peptidase S41A family
CB4_00671	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CB4_00673	COG2197	response regulator
CB4_00677	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CB4_00678	COG1040	competence protein
CB4_00679	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CB4_00683	COG4786	Flagellar basal body rod
CB4_00683	COG1256	bacterial-type flagellum assembly
CB4_00684	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CB4_00686	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CB4_00687	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CB4_00693	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CB4_00700	COG0765	amino acid transport
CB4_00701	COG1278	Cold shock
CB4_00702	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CB4_00703	COG0653	protein targeting
CB4_00704	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CB4_00705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_00706	COG3959	Transketolase, thiamine diphosphate binding domain
CB4_00707	COG3958	Transketolase
CB4_00710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CB4_00711	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CB4_00712	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CB4_00713	COG0505	Belongs to the CarA family
CB4_00714	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CB4_00715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CB4_00718	COG1067	ATP-dependent peptidase activity
CB4_00719	COG0137	argininosuccinate synthase activity
CB4_00720	COG0165	Argininosuccinate lyase
CB4_00721	COG2884	Cell division ATP-binding protein ftsE
CB4_00722	COG2177	Part of the ABC transporter FtsEX involved in
CB4_00723	COG4942	peptidase
CB4_00724	COG3409	Peptidoglycan-binding domain 1 protein
CB4_00724	COG0793	Belongs to the peptidase S41A family
CB4_00725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB4_00728	COG0556	nucleotide-excision repair
CB4_00729	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CB4_00730	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CB4_00732	COG0546	phosphoglycolate phosphatase activity
CB4_00733	COG0110	maltose O-acetyltransferase activity
CB4_00734	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CB4_00735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CB4_00736	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CB4_00737	COG0131	Imidazoleglycerol-phosphate dehydratase
CB4_00738	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CB4_00739	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CB4_00740	COG0107	imidazoleglycerol-phosphate synthase activity
CB4_00742	COG0140	phosphoribosyl-ATP diphosphatase activity
CB4_00742	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CB4_00743	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CB4_00744	COG1522	sequence-specific DNA binding
CB4_00760	COG0492	ferredoxin-NADP+ reductase activity
CB4_00761	COG1660	Displays ATPase and GTPase activities
CB4_00762	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CB4_00763	COG1481	regulation of sporulation
CB4_00764	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CB4_00765	COG0740	serine-type endopeptidase activity
CB4_00770	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CB4_00773	COG0126	phosphoglycerate kinase activity
CB4_00774	COG0149	triose-phosphate isomerase activity
CB4_00776	COG0148	phosphopyruvate hydratase activity
CB4_00777	COG0735	belongs to the Fur family
CB4_00778	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CB4_00780	COG1647	Serine aminopeptidase, S33
CB4_00781	COG0557	exoribonuclease II activity
CB4_00783	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CB4_00787	COG5001	Diguanylate cyclase
CB4_00787	COG3300	MHYT domain
CB4_00788	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_00789	COG2084	Dehydrogenase
CB4_00790	COG3883	PFAM NLP P60 protein
CB4_00790	COG0791	NLP P60 protein
CB4_00792	COG1473	amidohydrolase
CB4_00793	COG2171	N-acyltransferase activity
CB4_00800	COG3829	transcription factor binding
CB4_00800	COG3290	protein histidine kinase activity
CB4_00801	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CB4_00803	COG3321	synthase
CB4_00803	COG0604	alcohol dehydrogenase
CB4_00805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CB4_00806	COG1414	Transcriptional regulator
CB4_00809	COG0646	methionine synthase
CB4_00809	COG1410	methionine synthase
CB4_00810	COG0646	methionine synthase
CB4_00810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CB4_00811	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CB4_00812	COG0726	polysaccharide deacetylase
CB4_00813	COG3335	DDE superfamily endonuclease
CB4_00815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CB4_00816	COG0494	nUDIX hydrolase
CB4_00818	COG1612	heme a metabolic process
CB4_00820	COG1999	signal sequence binding
CB4_00824	COG2508	Transcriptional regulator
CB4_00824	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CB4_00825	COG0686	Belongs to the AlaDH PNT family
CB4_00832	COG1119	ATPase activity
CB4_00833	COG0277	FAD linked oxidase domain protein
CB4_00836	COG2268	Band 7 protein
CB4_00837	COG2404	hydrolase activity, acting on ester bonds
CB4_00838	COG3584	3D domain protein
CB4_00838	COG1388	LysM domain
CB4_00839	COG0482	sulfurtransferase activity
CB4_00840	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CB4_00842	COG4846	Membrane protein involved in cytochrome C biogenesis
CB4_00843	COG2186	Transcriptional regulator
CB4_00844	COG1620	l-lactate permease
CB4_00845	COG0247	lactate metabolic process
CB4_00846	COG1139	Iron-sulfur cluster binding protein
CB4_00847	COG1556	Lactate utilization protein
CB4_00848	COG0697	spore germination
CB4_00853	COG1012	belongs to the aldehyde dehydrogenase family
CB4_00854	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CB4_00856	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CB4_00857	COG0477	Major facilitator Superfamily
CB4_00858	COG1492	cobalamin metabolic process
CB4_00860	COG0778	Nitroreductase
CB4_00861	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CB4_00862	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CB4_00864	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CB4_00866	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CB4_00868	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CB4_00871	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CB4_00872	COG1739	Uncharacterized protein family UPF0029
CB4_00874	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CB4_00885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CB4_00886	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CB4_00887	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CB4_00888	COG0697	spore germination
CB4_00894	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CB4_00895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CB4_00896	COG1120	ATPase activity
CB4_00897	COG1393	Belongs to the ArsC family
CB4_00898	COG0436	Aminotransferase
CB4_00899	COG0450	alkyl hydroperoxide reductase
CB4_00927	COG0456	acetyltransferase
CB4_00931	COG0456	acetyltransferase
CB4_00936	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB4_00937	COG0509	glycine decarboxylation via glycine cleavage system
CB4_00938	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CB4_00939	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CB4_00940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CB4_00942	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CB4_00945	COG1191	sigma factor activity
CB4_00948	COG0396	ATPase activity
CB4_00949	COG0719	Fe-S assembly protein
CB4_00950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CB4_00951	COG0822	iron-sulfur transferase activity
CB4_00952	COG0719	Fe-S assembly protein
CB4_00953	COG4974	Belongs to the 'phage' integrase family
CB4_00955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CB4_00957	COG1917	Cupin 2, conserved barrel domain protein
CB4_00957	COG2207	Transcriptional regulator
CB4_00958	COG0697	spore germination
CB4_00961	COG0730	response to heat
CB4_00963	COG3377	Domain of unknown function (DUF1805)
CB4_00966	COG2208	phosphoserine phosphatase activity
CB4_00969	COG1366	Belongs to the anti-sigma-factor antagonist family
CB4_00971	COG0791	NLP P60 protein
CB4_00972	COG2205	protein histidine kinase activity
CB4_00973	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CB4_00976	COG5609	conserved protein (DUF2294)
CB4_00985	COG1376	ErfK ybiS ycfS ynhG family protein
CB4_00986	COG0697	spore germination
CB4_00987	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_00988	COG1233	COG1233 Phytoene dehydrogenase and related
CB4_00997	COG1376	ErfK ybiS ycfS ynhG family protein
CB4_00998	COG0739	heme binding
CB4_00999	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CB4_01001	COG4470	Protein conserved in bacteria
CB4_01004	COG2445	Protein of unknown function DUF86
CB4_01007	COG0789	Transcriptional regulator
CB4_01008	COG0697	spore germination
CB4_01009	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CB4_01011	COG1129	ABC transporter
CB4_01012	COG4214	carbohydrate transport
CB4_01014	COG0647	UMP catabolic process
CB4_01017	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CB4_01018	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_01019	COG0494	nUDIX hydrolase
CB4_01020	COG0840	transmembrane signaling receptor activity
CB4_01022	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CB4_01023	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_01024	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_01025	COG0183	Belongs to the thiolase family
CB4_01026	COG0183	Belongs to the thiolase family
CB4_01027	COG0559	Belongs to the binding-protein-dependent transport system permease family
CB4_01029	COG0411	ABC transporter
CB4_01030	COG0410	ABC transporter
CB4_01031	COG0683	leucine binding
CB4_01032	COG3396	Phenylacetate-CoA oxygenase
CB4_01035	COG2151	metal-sulfur cluster biosynthetic enzyme
CB4_01036	COG1012	belongs to the aldehyde dehydrogenase family
CB4_01037	COG2814	Major facilitator Superfamily
CB4_01038	COG0583	DNA-binding transcription factor activity
CB4_01039	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CB4_01040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CB4_01041	COG0626	cystathionine gamma-synthase activity
CB4_01042	COG4837	Protein of unknown function (DUF1462)
CB4_01043	COG4844	belongs to the
CB4_01045	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CB4_01046	COG0316	Belongs to the HesB IscA family
CB4_01048	COG3706	GGDEF domain
CB4_01048	COG5001	Diguanylate cyclase
CB4_01048	COG2203	Gaf domain
CB4_01048	COG4251	negative regulation of phosphorylation
CB4_01049	COG3706	GGDEF domain
CB4_01049	COG0745	RESPONSE REGULATOR receiver
CB4_01054	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CB4_01058	COG1252	NADH dehydrogenase
CB4_01060	COG3584	3D domain protein
CB4_01061	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CB4_01062	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CB4_01063	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CB4_01065	COG0028	Belongs to the TPP enzyme family
CB4_01066	COG0440	acetolactate synthase activity
CB4_01067	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CB4_01068	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CB4_01072	COG1401	restriction endodeoxyribonuclease activity
CB4_01074	COG1363	Peptidase, m42
CB4_01076	COG0569	domain protein
CB4_01077	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CB4_01079	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CB4_01080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CB4_01080	COG0072	phenylalanine-tRNA ligase activity
CB4_01082	COG1286	toxin biosynthetic process
CB4_01084	COG1193	negative regulation of DNA recombination
CB4_01085	COG3766	membrane
CB4_01086	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CB4_01094	COG0297	glycogen (starch) synthase activity
CB4_01094	COG0438	transferase activity, transferring glycosyl groups
CB4_01095	COG0728	peptidoglycan biosynthetic process
CB4_01096	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CB4_01099	COG1309	transcriptional regulator
CB4_01100	COG1024	Enoyl-CoA hydratase
CB4_01101	COG2086	electron transfer activity
CB4_01102	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CB4_01103	COG0471	metal ion transport
CB4_01104	COG3118	belongs to the thioredoxin family
CB4_01106	COG0322	excinuclease ABC activity
CB4_01108	COG1268	BioY protein
CB4_01109	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CB4_01110	COG2009	succinate dehydrogenase
CB4_01111	COG1053	succinate dehydrogenase
CB4_01112	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CB4_01113	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CB4_01114	COG0824	Thioesterase
CB4_01116	COG2197	response regulator
CB4_01119	COG5401	PFAM Sporulation and spore germination
CB4_01120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CB4_01121	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CB4_01124	COG0544	peptidyl-prolyl cis-trans isomerase activity
CB4_01125	COG0740	serine-type endopeptidase activity
CB4_01126	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CB4_01127	COG0470	DNA polymerase III
CB4_01127	COG1067	ATP-dependent peptidase activity
CB4_01129	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CB4_01130	COG0697	spore germination
CB4_01133	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CB4_01134	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CB4_01135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CB4_01138	COG0113	porphobilinogen synthase activity
CB4_01139	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CB4_01145	COG0525	valine-tRNA ligase activity
CB4_01146	COG0285	dihydrofolate synthase activity
CB4_01147	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CB4_01154	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CB4_01156	COG1459	type II secretion system
CB4_01158	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CB4_01163	COG0424	maF-like protein
CB4_01164	COG2003	Belongs to the UPF0758 family
CB4_01165	COG1077	Cell shape determining protein MreB Mrl
CB4_01166	COG1792	Involved in formation and maintenance of cell shape
CB4_01169	COG2894	cell division
CB4_01170	COG0772	Belongs to the SEDS family
CB4_01172	COG1994	Peptidase M50
CB4_01173	COG1530	ribonuclease E activity
CB4_01174	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CB4_01175	COG2868	ribosomal protein
CB4_01176	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CB4_01178	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CB4_01180	COG0586	Pfam SNARE associated Golgi protein
CB4_01181	COG4492	Belongs to the UPF0735 family
CB4_01182	COG0460	homoserine dehydrogenase
CB4_01183	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CB4_01184	COG0083	homoserine kinase activity
CB4_01185	COG0077	Prephenate dehydratase
CB4_01189	COG0632	four-way junction helicase activity
CB4_01190	COG2255	four-way junction helicase activity
CB4_01193	COG2385	sporulation resulting in formation of a cellular spore
CB4_01194	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CB4_01195	COG0343	queuine tRNA-ribosyltransferase activity
CB4_01196	COG1862	Preprotein translocase
CB4_01197	COG0531	amino acid
CB4_01199	COG2244	polysaccharide biosynthetic process
CB4_01201	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CB4_01201	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CB4_01202	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CB4_01202	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CB4_01203	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CB4_01203	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CB4_01204	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CB4_01205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CB4_01206	COG1490	D-aminoacyl-tRNA deacylase activity
CB4_01209	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CB4_01211	COG0124	histidyl-tRNA synthetase
CB4_01212	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CB4_01213	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CB4_01215	COG1959	2 iron, 2 sulfur cluster binding
CB4_01216	COG1104	cysteine desulfurase activity
CB4_01221	COG0840	transmembrane signaling receptor activity
CB4_01223	COG0628	permease
CB4_01225	COG4472	Bacterial protein of unknown function (DUF965)
CB4_01227	COG3906	Belongs to the UPF0473 family
CB4_01228	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CB4_01232	COG0768	penicillin binding
CB4_01233	COG0671	phosphoesterase, PA-phosphatase related
CB4_01235	COG3876	Protein conserved in bacteria
CB4_01237	COG3853	Toxic anion resistance protein (TelA)
CB4_01245	COG1215	transferase activity, transferring glycosyl groups
CB4_01247	COG0745	RESPONSE REGULATOR receiver
CB4_01248	COG5002	protein histidine kinase activity
CB4_01251	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CB4_01252	COG0726	polysaccharide deacetylase
CB4_01254	COG0393	Putative heavy-metal-binding
CB4_01261	COG4221	oxidoreductase activity
CB4_01262	COG3177	Filamentation induced by cAMP protein fic
CB4_01270	COG2733	membrane
CB4_01271	COG2733	membrane
CB4_01276	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CB4_01279	COG1191	sigma factor activity
CB4_01282	COG1278	Cold shock
CB4_01286	COG1027	Aspartate ammonia-lyase
CB4_01290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CB4_01291	COG1876	peptidase activity
CB4_01298	COG0840	transmembrane signaling receptor activity
CB4_01298	COG3290	protein histidine kinase activity
CB4_01300	COG3949	Membrane
CB4_01301	COG0681	Belongs to the peptidase S26 family
CB4_01305	COG0022	dehydrogenase e1 component
CB4_01306	COG0508	dehydrogenase complex catalyzes the overall conversion of
CB4_01308	COG0840	transmembrane signaling receptor activity
CB4_01309	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CB4_01311	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CB4_01312	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CB4_01313	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CB4_01314	COG1534	Rna-binding protein
CB4_01315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CB4_01316	COG1713	HD superfamily hydrolase involved in NAD metabolism
CB4_01317	COG0799	negative regulation of ribosome biogenesis
CB4_01318	COG2226	methyltransferase
CB4_01321	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CB4_01329	COG2333	competence protein COMEC
CB4_01329	COG0658	competence protein
CB4_01330	COG1595	DNA-templated transcription, initiation
CB4_01332	COG1466	dna polymerase III delta subunit
CB4_01333	COG0268	Binds directly to 16S ribosomal RNA
CB4_01335	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_01337	COG0006	proline dipeptidase activity
CB4_01340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CB4_01341	COG1420	regulation of RNA biosynthetic process
CB4_01342	COG0459	protein refolding
CB4_01344	COG0443	Heat shock 70 kDa protein
CB4_01345	COG0484	heat shock protein binding
CB4_01346	COG2264	protein methyltransferase activity
CB4_01347	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CB4_01348	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CB4_01349	COG3290	protein histidine kinase activity
CB4_01350	COG4565	transcriptional regulatory protein
CB4_01351	COG1301	dicarboxylic acid transport
CB4_01352	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CB4_01354	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CB4_01355	COG2815	serine threonine protein kinase
CB4_01355	COG0515	serine threonine protein kinase
CB4_01397	COG1283	sodium-dependent phosphate transmembrane transporter activity
CB4_01399	COG0741	lytic transglycosylase activity
CB4_01406	COG0840	transmembrane signaling receptor activity
CB4_01406	COG5278	phosphoserine phosphatase activity
CB4_01407	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CB4_01408	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_01413	COG1278	Cold shock
CB4_01414	COG2733	membrane
CB4_01415	COG4191	Histidine kinase
CB4_01416	COG0784	Response regulator, receiver
CB4_01417	COG1181	Belongs to the D-alanine--D-alanine ligase family
CB4_01418	COG0583	DNA-binding transcription factor activity
CB4_01419	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_01420	COG3011	Protein conserved in bacteria
CB4_01421	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CB4_01423	COG1610	YqeY-like protein
CB4_01428	COG1702	phosphate starvation-inducible protein PhoH
CB4_01429	COG1480	7TM receptor with intracellular HD hydrolase
CB4_01430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CB4_01431	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CB4_01432	COG0295	cytidine deaminase activity
CB4_01433	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CB4_01435	COG1381	Involved in DNA repair and RecF pathway recombination
CB4_01436	COG0752	glycyl-tRNA synthetase alpha subunit
CB4_01437	COG0751	glycine-tRNA ligase activity
CB4_01438	COG0517	IMP dehydrogenase activity
CB4_01439	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CB4_01440	COG0358	DNA primase activity
CB4_01441	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB4_01443	COG1960	acyl-CoA dehydrogenase activity
CB4_01444	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_01446	COG2384	SAM-dependent methyltransferase
CB4_01447	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CB4_01451	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CB4_01453	COG0312	modulator of DNA gyrase
CB4_01454	COG0312	modulator of DNA gyrase
CB4_01455	COG2827	Endonuclease containing a URI domain
CB4_01466	COG0531	amino acid
CB4_01469	COG2070	2-Nitropropane dioxygenase
CB4_01472	COG0310	cobalt ion transport
CB4_01473	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CB4_01475	COG1122	ATPase activity
CB4_01480	COG0523	cobalamin synthesis protein
CB4_01482	COG0701	Predicted permease
CB4_01483	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CB4_01486	COG0584	glycerophosphoryl diester phosphodiesterase
CB4_01489	COG0004	ammonium transporteR
CB4_01490	COG1733	regulation of RNA biosynthetic process
CB4_01493	COG2326	polyphosphate kinase activity
CB4_01494	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CB4_01496	COG1114	Component of the transport system for branched-chain amino acids
CB4_01500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_01502	COG1116	anion transmembrane transporter activity
CB4_01503	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CB4_01504	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CB4_01505	COG0351	phosphomethylpyrimidine kinase
CB4_01508	COG0840	transmembrane signaling receptor activity
CB4_01510	COG1607	acyl-coa hydrolase
CB4_01512	COG0390	transport system, permease component
CB4_01513	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CB4_01514	COG0705	Rhomboid family
CB4_01514	COG0457	Tetratricopeptide repeat
CB4_01516	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CB4_01519	COG1363	Peptidase, m42
CB4_01522	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_01523	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CB4_01524	COG0387	Pfam Sodium calcium exchanger
CB4_01525	COG3773	Cell wall hydrolase
CB4_01525	COG3409	Peptidoglycan-binding domain 1 protein
CB4_01526	COG0640	Transcriptional regulator
CB4_01530	COG2050	protein possibly involved in aromatic compounds catabolism
CB4_01533	COG4471	UPF0298 protein
CB4_01534	COG2199	diguanylate cyclase activity
CB4_01534	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_01535	COG0589	response to stress
CB4_01539	COG2165	general secretion pathway protein
CB4_01544	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CB4_01547	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CB4_01551	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CB4_01552	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CB4_01553	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CB4_01554	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CB4_01555	COG0095	Lipoate-protein ligase
CB4_01558	COG0579	oxidoreductase
CB4_01561	COG2824	Alkylphosphonate utilization operon protein PhnA
CB4_01562	COG0745	RESPONSE REGULATOR receiver
CB4_01562	COG2972	Histidine kinase
CB4_01564	COG0596	Alpha beta hydrolase
CB4_01565	COG0840	transmembrane signaling receptor activity
CB4_01565	COG3290	protein histidine kinase activity
CB4_01568	COG0277	FAD linked oxidase domain protein
CB4_01569	COG0247	lactate metabolic process
CB4_01570	COG0789	Transcriptional regulator
CB4_01577	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB4_01579	COG1666	GTP binding
CB4_01580	COG1321	iron dependent repressor
CB4_01581	COG1752	Esterase of the alpha-beta hydrolase superfamily
CB4_01583	COG3872	metal-dependent enzyme
CB4_01585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CB4_01586	COG0006	proline dipeptidase activity
CB4_01587	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CB4_01588	COG3290	protein histidine kinase activity
CB4_01588	COG0840	transmembrane signaling receptor activity
CB4_01589	COG3854	ATPases associated with a variety of cellular activities
CB4_01597	COG0511	ligase activity, forming carbon-carbon bonds
CB4_01598	COG0439	Biotin carboxylase
CB4_01599	COG1302	Protein conserved in bacteria
CB4_01602	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CB4_01603	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CB4_01604	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CB4_01605	COG1570	exodeoxyribonuclease VII activity
CB4_01606	COG1722	exodeoxyribonuclease VII activity
CB4_01608	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CB4_01609	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CB4_01610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CB4_01611	COG1438	arginine binding
CB4_01612	COG0497	DNA recombination
CB4_01613	COG0750	zinc metalloprotease
CB4_01614	COG0745	RESPONSE REGULATOR receiver
CB4_01616	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CB4_01617	COG0613	PHP domain protein
CB4_01619	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CB4_01627	COG1982	Orn Lys Arg decarboxylase major
CB4_01629	COG4493	Belongs to the UPF0637 family
CB4_01631	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CB4_01633	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CB4_01635	COG3290	protein histidine kinase activity
CB4_01635	COG3829	transcription factor binding
CB4_01640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CB4_01641	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB4_01642	COG3706	GGDEF domain
CB4_01642	COG0745	RESPONSE REGULATOR receiver
CB4_01645	COG1393	Belongs to the ArsC family
CB4_01646	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CB4_01647	COG1024	Enoyl-CoA hydratase
CB4_01649	COG0439	Biotin carboxylase
CB4_01651	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CB4_01652	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CB4_01653	COG1309	transcriptional regulator
CB4_01654	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CB4_01655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CB4_01656	COG0275	rRNA processing
CB4_01659	COG0768	penicillin binding
CB4_01660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CB4_01661	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CB4_01662	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CB4_01663	COG0772	Belongs to the SEDS family
CB4_01664	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CB4_01665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CB4_01667	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CB4_01670	COG3856	small basic protein
CB4_01671	COG0849	cell division
CB4_01672	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CB4_01673	COG3647	Membrane
CB4_01675	COG1191	sigma factor activity
CB4_01676	COG1191	sigma factor activity
CB4_01678	COG1873	PFAM PRC-barrel domain
CB4_01680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CB4_01681	COG1799	cell septum assembly
CB4_01682	COG0762	integral membrane protein
CB4_01683	COG2302	S4 RNA-binding domain
CB4_01684	COG3599	regulation of cell shape
CB4_01685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CB4_01686	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CB4_01687	COG0564	pseudouridine synthase activity
CB4_01690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CB4_01691	COG0505	Belongs to the CarA family
CB4_01692	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CB4_01693	COG0543	2 iron, 2 sulfur cluster binding
CB4_01694	COG0167	dihydroorotate dehydrogenase activity
CB4_01696	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CB4_01699	COG2244	polysaccharide biosynthetic process
CB4_01702	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CB4_01703	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CB4_01704	COG1561	YicC-like family, N-terminal region
CB4_01705	COG2052	Domain of unknown function (DUF370)
CB4_01706	COG0194	GDP metabolic process
CB4_01708	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CB4_01709	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CB4_01710	COG0242	peptide deformylase activity
CB4_01711	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CB4_01712	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CB4_01712	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CB4_01713	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CB4_01714	COG0631	protein serine/threonine phosphatase activity
CB4_01715	COG2815	serine threonine protein kinase
CB4_01715	COG0515	serine threonine protein kinase
CB4_01717	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CB4_01718	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CB4_01719	COG1302	Protein conserved in bacteria
CB4_01720	COG1461	Dihydroxyacetone kinase
CB4_01721	COG1307	EDD domain protein, DegV family
CB4_01722	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CB4_01723	COG1285	pathogenesis
CB4_01725	COG0742	ribosomal rna small subunit methyltransferase
CB4_01726	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CB4_01727	COG3314	Sporulation integral membrane protein YlbJ
CB4_01728	COG1752	Esterase of the alpha-beta hydrolase superfamily
CB4_01729	COG3480	Lon protease (S16) C-terminal proteolytic domain
CB4_01730	COG1323	Belongs to the UPF0348 family
CB4_01732	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CB4_01734	COG0416	fatty acid biosynthetic process
CB4_01736	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CB4_01737	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_01738	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CB4_01739	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CB4_01740	COG0571	ribonuclease III activity
CB4_01742	COG1196	nuclear chromosome segregation
CB4_01743	COG0552	protein localization to endoplasmic reticulum
CB4_01744	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CB4_01745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CB4_01747	COG1837	Belongs to the UPF0109 family
CB4_01749	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CB4_01750	COG0336	Belongs to the RNA methyltransferase TrmD family
CB4_01751	COG0335	large ribosomal subunit rRNA binding
CB4_01752	COG0681	Belongs to the peptidase S26 family
CB4_01754	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CB4_01756	COG2257	FlhB HrpN YscU SpaS Family
CB4_01757	COG0792	nuclease activity
CB4_01758	COG0606	chelatase, subunit chli
CB4_01766	COG1396	sequence-specific DNA binding
CB4_01782	COG1484	DNA-dependent DNA replication
CB4_01784	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CB4_01819	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_01826	COG0606	chelatase, subunit chli
CB4_01828	COG0045	succinate-CoA ligase (ADP-forming) activity
CB4_01829	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CB4_01830	COG0758	DNA mediated transformation
CB4_01831	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CB4_01832	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CB4_01833	COG4974	Belongs to the 'phage' integrase family
CB4_01834	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CB4_01835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CB4_01836	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CB4_01837	COG1815	bacterial-type flagellum-dependent cell motility
CB4_01838	COG1558	bacterial-type flagellum-dependent cell motility
CB4_01839	COG1677	Flagellar hook-basal body complex protein FliE
CB4_01840	COG1766	The M ring may be actively involved in energy transduction
CB4_01841	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CB4_01843	COG1157	protein secretion by the type III secretion system
CB4_01846	COG3144	bacterial-type flagellum assembly
CB4_01847	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CB4_01849	COG4786	Flagellar basal body rod
CB4_01852	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CB4_01853	COG1776	CheC inhibitor of MCP methylation
CB4_01853	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CB4_01854	COG2201	protein-glutamate methylesterase activity
CB4_01855	COG3190	flagellar
CB4_01856	COG1338	Plays a role in the flagellum-specific transport system
CB4_01857	COG1987	bacterial-type flagellum assembly
CB4_01858	COG1684	flagellar biosynthetic protein fliR
CB4_01859	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CB4_01860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CB4_01861	COG1419	protein localization to endoplasmic reticulum
CB4_01862	COG0455	bacterial-type flagellum organization
CB4_01863	COG2201	protein-glutamate methylesterase activity
CB4_01864	COG2201	protein-glutamate methylesterase activity
CB4_01865	COG2198	Histidine kinase
CB4_01865	COG0643	Histidine kinase
CB4_01866	COG0835	chemotaxis
CB4_01867	COG1776	CheC inhibitor of MCP methylation
CB4_01868	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CB4_01870	COG1191	sigma factor activity
CB4_01874	COG0052	Belongs to the universal ribosomal protein uS2 family
CB4_01875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CB4_01876	COG0528	UMP kinase activity
CB4_01877	COG0233	cytoplasmic translational termination
CB4_01878	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CB4_01879	COG4589	Belongs to the CDS family
CB4_01881	COG0750	zinc metalloprotease
CB4_01882	COG0442	prolyl-tRNA aminoacylation
CB4_01883	COG2176	DNA-directed DNA polymerase activity
CB4_01884	COG0779	Required for maturation of 30S ribosomal subunits
CB4_01885	COG0195	Participates in both transcription termination and antitermination
CB4_01886	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CB4_01887	COG1358	cellular component organization or biogenesis
CB4_01888	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CB4_01889	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CB4_01890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CB4_01891	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CB4_01892	COG0196	riboflavin kinase activity
CB4_01893	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CB4_01894	COG1185	polyribonucleotide nucleotidyltransferase activity
CB4_01895	COG0726	polysaccharide deacetylase
CB4_01896	COG0612	Peptidase, M16
CB4_01897	COG0756	dUTP diphosphatase activity
CB4_01899	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_01901	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CB4_01907	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CB4_01908	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CB4_01909	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CB4_01910	COG0527	aspartate kinase activity
CB4_01911	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CB4_01912	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CB4_01915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CB4_01918	COG1657	PFAM Prenyltransferase squalene oxidase
CB4_01927	COG3335	DDE superfamily endonuclease
CB4_01929	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CB4_01938	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CB4_01938	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CB4_01940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CB4_01941	COG0431	NADPH-dependent FMN reductase
CB4_01942	COG0596	Alpha beta hydrolase
CB4_01945	COG2197	response regulator
CB4_01950	COG2814	Major facilitator Superfamily
CB4_01952	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CB4_01953	COG4191	Histidine kinase
CB4_01955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CB4_01956	COG1272	protein, Hemolysin III
CB4_01961	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CB4_01963	COG1714	RDD family
CB4_01966	COG0772	Belongs to the SEDS family
CB4_01969	COG1388	LysM domain
CB4_01969	COG0791	NLP P60 protein
CB4_01970	COG0730	response to heat
CB4_01971	COG1902	pentaerythritol trinitrate reductase activity
CB4_01972	COG1959	2 iron, 2 sulfur cluster binding
CB4_01974	COG0436	Aminotransferase
CB4_01975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_01977	COG3186	Phenylalanine-4-hydroxylase
CB4_01978	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CB4_01979	COG0501	Belongs to the peptidase M48B family
CB4_01980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CB4_01982	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CB4_01983	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CB4_01984	COG1842	Phage shock protein A
CB4_01987	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_01991	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CB4_01992	COG1984	allophanate hydrolase subunit 2
CB4_01993	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CB4_01994	COG3829	transcription factor binding
CB4_01994	COG3290	protein histidine kinase activity
CB4_01995	COG1960	acyl-CoA dehydrogenase activity
CB4_01996	COG0183	Belongs to the thiolase family
CB4_01999	COG0024	Methionine aminopeptidase
CB4_02000	COG0745	RESPONSE REGULATOR receiver
CB4_02000	COG2972	Histidine kinase
CB4_02001	COG0745	RESPONSE REGULATOR receiver
CB4_02001	COG2972	Histidine kinase
CB4_02002	COG2368	4-hydroxyphenylacetate
CB4_02003	COG0531	amino acid
CB4_02004	COG1309	transcriptional regulator
CB4_02005	COG2814	Major facilitator Superfamily
CB4_02006	COG1846	Transcriptional regulator
CB4_02008	COG3885	ferrous iron binding
CB4_02008	COG2078	PFAM AMMECR1 domain protein
CB4_02009	COG0174	glutamine synthetase
CB4_02010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CB4_02012	COG0179	Fumarylacetoacetate (FAA) hydrolase
CB4_02014	COG3706	GGDEF domain
CB4_02014	COG0745	RESPONSE REGULATOR receiver
CB4_02016	COG2608	mercury ion transmembrane transporter activity
CB4_02017	COG2217	Heavy metal translocating P-type atpase
CB4_02018	COG0655	NAD(P)H dehydrogenase (quinone) activity
CB4_02020	COG2153	protein acetylation
CB4_02021	COG1846	Transcriptional regulator
CB4_02022	COG0745	RESPONSE REGULATOR receiver
CB4_02023	COG2770	Histidine kinase
CB4_02023	COG2205	protein histidine kinase activity
CB4_02027	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CB4_02037	COG0189	ligase activity
CB4_02038	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CB4_02041	COG0577	efflux transmembrane transporter activity
CB4_02043	COG1136	(ABC) transporter
CB4_02043	COG0577	efflux transmembrane transporter activity
CB4_02047	COG1012	belongs to the aldehyde dehydrogenase family
CB4_02049	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB4_02050	COG2112	serine threonine protein kinase
CB4_02055	COG1177	transmembrane transport
CB4_02057	COG1349	DNA-binding transcription factor activity
CB4_02058	COG0561	phosphatase activity
CB4_02059	COG2076	Multidrug Resistance protein
CB4_02060	COG2076	Multidrug Resistance protein
CB4_02064	COG1131	(ABC) transporter
CB4_02067	COG2373	Large extracellular alpha-helical protein
CB4_02068	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CB4_02071	COG1950	PFAM Membrane protein of
CB4_02075	COG0586	Pfam SNARE associated Golgi protein
CB4_02077	COG0740	serine-type endopeptidase activity
CB4_02084	COG0517	IMP dehydrogenase activity
CB4_02085	COG1164	Oligoendopeptidase f
CB4_02087	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CB4_02089	COG0745	RESPONSE REGULATOR receiver
CB4_02090	COG5002	protein histidine kinase activity
CB4_02095	COG0427	acetyl-CoA hydrolase
CB4_02096	COG0210	DNA helicase
CB4_02097	COG2996	Protein conserved in bacteria
CB4_02102	COG1388	LysM domain
CB4_02102	COG0791	NLP P60 protein
CB4_02105	COG1024	Enoyl-CoA hydratase
CB4_02105	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_02106	COG0183	Belongs to the thiolase family
CB4_02107	COG1960	acyl-CoA dehydrogenase activity
CB4_02108	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_02110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CB4_02112	COG1164	Oligoendopeptidase f
CB4_02114	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_02115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_02119	COG2962	Rard protein
CB4_02120	COG1388	LysM domain
CB4_02120	COG3858	chitin binding
CB4_02121	COG1278	Cold shock
CB4_02122	COG1329	Transcriptional regulator
CB4_02129	COG1388	LysM domain
CB4_02129	COG3858	chitin binding
CB4_02130	COG2261	transglycosylase associated protein
CB4_02131	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB4_02132	COG0116	Belongs to the methyltransferase superfamily
CB4_02138	COG4637	Psort location Cytoplasmic, score
CB4_02140	COG1309	transcriptional regulator
CB4_02141	COG1233	COG1233 Phytoene dehydrogenase and related
CB4_02142	COG2204	response regulator
CB4_02143	COG4191	Histidine kinase
CB4_02147	COG0506	proline dehydrogenase activity
CB4_02148	COG0517	IMP dehydrogenase activity
CB4_02150	COG0316	Belongs to the HesB IscA family
CB4_02151	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CB4_02152	COG0352	thiamine-phosphate diphosphorylase activity
CB4_02153	COG0187	DNA topoisomerase II activity
CB4_02154	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CB4_02155	COG1098	S1 RNA binding domain
CB4_02156	COG0540	Belongs to the ATCase OTCase family
CB4_02157	COG1309	transcriptional regulator
CB4_02158	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CB4_02158	COG2124	cytochrome p450
CB4_02160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CB4_02165	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CB4_02166	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CB4_02169	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CB4_02170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CB4_02172	COG0589	response to stress
CB4_02173	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CB4_02175	COG0066	3-isopropylmalate dehydratase activity
CB4_02176	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CB4_02177	COG0583	DNA-binding transcription factor activity
CB4_02179	COG0697	spore germination
CB4_02181	COG2002	toxin-antitoxin pair type II binding
CB4_02186	COG0784	Response regulator, receiver
CB4_02186	COG3437	response regulator, receiver
CB4_02187	COG1199	ATP-dependent helicase activity
CB4_02190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CB4_02192	COG2002	toxin-antitoxin pair type II binding
CB4_02194	COG1309	transcriptional regulator
CB4_02198	COG1090	epimerase
CB4_02199	COG0667	Aldo Keto reductase
CB4_02202	COG3858	chitin binding
CB4_02204	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB4_02205	COG0697	spore germination
CB4_02206	COG2223	nitrite transmembrane transporter activity
CB4_02208	COG2391	methyltransferase activity
CB4_02209	COG3739	integral membrane protein
CB4_02211	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CB4_02213	COG1115	amino acid carrier protein
CB4_02215	COG4191	Histidine kinase
CB4_02216	COG0784	Response regulator, receiver
CB4_02217	COG0640	Transcriptional regulator
CB4_02218	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CB4_02219	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CB4_02224	COG4106	trans-aconitate 2-methyltransferase activity
CB4_02225	COG1346	cytolysis
CB4_02231	COG1842	Phage shock protein A
CB4_02233	COG4585	Histidine kinase
CB4_02234	COG2197	response regulator
CB4_02235	COG5002	protein histidine kinase activity
CB4_02241	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_02242	COG1979	alcohol dehydrogenase
CB4_02244	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CB4_02245	COG4129	membrane
CB4_02247	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB4_02247	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB4_02248	COG2210	Belongs to the sulfur carrier protein TusA family
CB4_02249	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB4_02249	COG0425	Belongs to the sulfur carrier protein TusA family
CB4_02250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CB4_02254	COG1459	type II secretion system
CB4_02260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CB4_02262	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CB4_02263	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CB4_02264	COG0489	protein tyrosine kinase activity
CB4_02266	COG0297	glycogen (starch) synthase activity
CB4_02268	COG0297	glycogen (starch) synthase activity
CB4_02272	COG0438	transferase activity, transferring glycosyl groups
CB4_02277	COG0488	(ABC) transporter
CB4_02280	COG0328	RNA-DNA hybrid ribonuclease activity
CB4_02281	COG0527	aspartate kinase activity
CB4_02287	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_02296	COG3115	cell septum assembly
CB4_02301	COG2003	Belongs to the UPF0758 family
CB4_02358	COG4974	Belongs to the 'phage' integrase family
CB4_02365	COG0419	ATPase involved in DNA repair
CB4_02368	COG0629	single-stranded DNA binding
CB4_02380	COG3331	DNA recombination
CB4_02406	COG2359	stage V sporulation protein S
CB4_02407	COG1191	sigma factor activity
CB4_02411	COG1876	peptidase activity
CB4_02417	COG0270	DNA (cytosine-5-)-methyltransferase activity
CB4_02420	COG3646	Phage regulatory protein
CB4_02420	COG3645	SOS response
CB4_02433	COG1113	amino acid transport
CB4_02434	COG0833	amino acid
CB4_02435	COG1113	amino acid transport
CB4_02446	COG2871	sodium ion transport
CB4_02458	COG0697	spore germination
CB4_02460	COG1902	pentaerythritol trinitrate reductase activity
CB4_02464	COG0583	DNA-binding transcription factor activity
CB4_02466	COG0179	Fumarylacetoacetate (FAA) hydrolase
CB4_02469	COG2860	membrane
CB4_02472	COG0791	NLP P60 protein
CB4_02478	COG0840	transmembrane signaling receptor activity
CB4_02479	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_02480	COG2076	Multidrug Resistance protein
CB4_02481	COG2076	Multidrug Resistance protein
CB4_02483	COG2814	Major facilitator Superfamily
CB4_02484	COG0154	amidase activity
CB4_02485	COG1278	Cold shock
CB4_02486	COG0513	Belongs to the DEAD box helicase family
CB4_02487	COG1329	Transcriptional regulator
CB4_02489	COG0671	phosphoesterase, PA-phosphatase related
CB4_02490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CB4_02491	COG0586	Pfam SNARE associated Golgi protein
CB4_02492	COG1131	(ABC) transporter
CB4_02493	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CB4_02496	COG3150	esterase
CB4_02497	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CB4_02499	COG4978	Transcriptional regulator
CB4_02499	COG0789	Transcriptional regulator
CB4_02500	COG2814	Major facilitator Superfamily
CB4_02501	COG0697	spore germination
CB4_02502	COG0531	amino acid
CB4_02504	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CB4_02505	COG4086	secreted protein
CB4_02506	COG0460	homoserine dehydrogenase
CB4_02508	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CB4_02509	COG0427	acetyl-CoA hydrolase
CB4_02512	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CB4_02515	COG2815	serine threonine protein kinase
CB4_02515	COG0515	serine threonine protein kinase
CB4_02519	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CB4_02522	COG0322	excinuclease ABC activity
CB4_02523	COG0521	Mo-molybdopterin cofactor biosynthetic process
CB4_02528	COG1695	Transcriptional regulator
CB4_02529	COG0772	Belongs to the SEDS family
CB4_02530	COG0745	RESPONSE REGULATOR receiver
CB4_02531	COG5002	protein histidine kinase activity
CB4_02532	COG2132	Multicopper oxidase
CB4_02533	COG1136	(ABC) transporter
CB4_02534	COG0577	efflux transmembrane transporter activity
CB4_02538	COG1686	Belongs to the peptidase S11 family
CB4_02539	COG0194	GDP metabolic process
CB4_02541	COG3424	synthase
CB4_02542	COG1755	Isoprenylcysteine carboxyl methyltransferase
CB4_02543	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_02545	COG0303	'Molybdopterin
CB4_02546	COG1763	Mo-molybdopterin cofactor biosynthetic process
CB4_02547	COG0314	molybdopterin synthase activity
CB4_02549	COG5001	Diguanylate cyclase
CB4_02549	COG4251	negative regulation of phosphorylation
CB4_02549	COG2203	Gaf domain
CB4_02549	COG3706	GGDEF domain
CB4_02551	COG1132	(ABC) transporter
CB4_02554	COG1090	epimerase
CB4_02555	COG1595	DNA-templated transcription, initiation
CB4_02556	COG2814	Major facilitator Superfamily
CB4_02557	COG0640	Transcriptional regulator
CB4_02559	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CB4_02562	COG0783	Belongs to the Dps family
CB4_02563	COG0697	spore germination
CB4_02566	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB4_02567	COG1802	Transcriptional regulator
CB4_02568	COG0697	spore germination
CB4_02571	COG2132	Multicopper oxidase
CB4_02572	COG0672	)-iron permease
CB4_02574	COG5002	protein histidine kinase activity
CB4_02576	COG0488	(ABC) transporter
CB4_02579	COG1024	Enoyl-CoA hydratase
CB4_02583	COG0583	DNA-binding transcription factor activity
CB4_02585	COG2364	Membrane
CB4_02587	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CB4_02588	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CB4_02589	COG0656	L-ascorbic acid biosynthetic process
CB4_02591	COG0537	adenosine 5'-monophosphoramidase activity
CB4_02592	COG1061	Type III restriction enzyme res subunit
CB4_02596	COG0659	secondary active sulfate transmembrane transporter activity
CB4_02597	COG0789	Transcriptional regulator
CB4_02600	COG0697	spore germination
CB4_02601	COG0640	Transcriptional regulator
CB4_02602	COG2814	Major facilitator Superfamily
CB4_02603	COG1760	l-serine dehydratase
CB4_02605	COG1760	l-serine dehydratase
CB4_02606	COG1760	l-serine dehydratase
CB4_02608	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CB4_02611	COG0840	transmembrane signaling receptor activity
CB4_02612	COG0726	polysaccharide deacetylase
CB4_02615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CB4_02618	COG1116	anion transmembrane transporter activity
CB4_02628	COG1396	sequence-specific DNA binding
CB4_02633	COG1846	Transcriptional regulator
CB4_02634	COG1566	PFAM secretion protein HlyD family protein
CB4_02635	COG1566	PFAM secretion protein HlyD family protein
CB4_02636	COG2814	Major facilitator Superfamily
CB4_02639	COG0446	pyridine nucleotide-disulphide oxidoreductase
CB4_02640	COG1252	NADH dehydrogenase
CB4_02645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CB4_02648	COG5609	conserved protein (DUF2294)
CB4_02649	COG3223	Belongs to the PsiE family
CB4_02650	COG2427	Protein of unknown function (DUF1641)
CB4_02651	COG3383	formate dehydrogenase (NAD+) activity
CB4_02652	COG1968	undecaprenyl-diphosphatase activity
CB4_02653	COG4608	Belongs to the ABC transporter superfamily
CB4_02655	COG0444	Belongs to the ABC transporter superfamily
CB4_02657	COG0601	transmembrane transport
CB4_02658	COG0747	negative chemotaxis
CB4_02659	COG0672	)-iron permease
CB4_02670	COG1012	belongs to the aldehyde dehydrogenase family
CB4_02671	COG0069	glutamate synthase activity
CB4_02672	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CB4_02683	COG0840	transmembrane signaling receptor activity
CB4_02685	COG1132	(ABC) transporter
CB4_02687	COG1846	Transcriptional regulator
CB4_02690	COG5002	protein histidine kinase activity
CB4_02694	COG1657	PFAM Prenyltransferase squalene oxidase
CB4_02706	COG4974	Belongs to the 'phage' integrase family
CB4_02714	COG0431	NADPH-dependent FMN reductase
CB4_02725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CB4_02726	COG1215	transferase activity, transferring glycosyl groups
CB4_02728	COG2124	cytochrome p450
CB4_02730	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CB4_02733	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CB4_02734	COG5002	protein histidine kinase activity
CB4_02735	COG0745	RESPONSE REGULATOR receiver
CB4_02736	COG0745	RESPONSE REGULATOR receiver
CB4_02737	COG5002	protein histidine kinase activity
CB4_02739	COG1131	(ABC) transporter
CB4_02742	COG0791	NLP P60 protein
CB4_02742	COG1388	LysM domain
CB4_02745	COG2076	Multidrug Resistance protein
CB4_02746	COG1309	transcriptional regulator
CB4_02748	COG0586	Pfam SNARE associated Golgi protein
CB4_02749	COG0840	transmembrane signaling receptor activity
CB4_02752	COG2205	protein histidine kinase activity
CB4_02753	COG1587	Uroporphyrinogen-III synthase
CB4_02756	COG1694	Mazg nucleotide pyrophosphohydrolase
CB4_02759	COG1115	amino acid carrier protein
CB4_02760	COG0475	glutathione-regulated potassium exporter activity
CB4_02763	COG0640	Transcriptional regulator
CB4_02773	COG3091	SprT-like family
CB4_02776	COG1176	ABC-type spermidine putrescine transport system, permease component I
CB4_02778	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CB4_02779	COG0542	response to heat
CB4_02780	COG2814	Major facilitator Superfamily
CB4_02782	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_02783	COG5002	protein histidine kinase activity
CB4_02787	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CB4_02791	COG1215	transferase activity, transferring glycosyl groups
CB4_02794	COG1547	Domain of unknown function (DUF309)
CB4_02796	COG3584	3D domain protein
CB4_02796	COG1388	LysM domain
CB4_02797	COG0419	ATPase involved in DNA repair
CB4_02798	COG0420	3'-5' exonuclease activity
CB4_02799	COG1074	ATP-dependent DNA helicase activity
CB4_02800	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CB4_02801	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CB4_02806	COG3279	Response regulator of the LytR AlgR family
CB4_02807	COG2972	Histidine kinase
CB4_02807	COG0745	RESPONSE REGULATOR receiver
CB4_02809	COG0488	(ABC) transporter
CB4_02812	COG0704	Plays a role in the regulation of phosphate uptake
CB4_02813	COG5018	Exonuclease
CB4_02814	COG2259	Doxx family
CB4_02815	COG0243	molybdopterin cofactor binding
CB4_02818	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CB4_02820	COG0531	amino acid
CB4_02822	COG3848	Pyruvate phosphate dikinase
CB4_02822	COG0574	Belongs to the PEP-utilizing enzyme family
CB4_02823	COG0508	dehydrogenase complex catalyzes the overall conversion of
CB4_02823	COG0596	Alpha beta hydrolase
CB4_02824	COG2404	hydrolase activity, acting on ester bonds
CB4_02826	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_02828	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CB4_02831	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_02832	COG3103	Sh3 type 3 domain protein
CB4_02832	COG1388	LysM domain
CB4_02832	COG0791	NLP P60 protein
CB4_02833	COG0826	peptidase U32
CB4_02834	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CB4_02835	COG4224	UPF0291 protein
CB4_02836	COG1388	LysM domain
CB4_02837	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CB4_02838	COG2839	Protein conserved in bacteria
CB4_02841	COG2860	membrane
CB4_02842	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CB4_02843	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CB4_02844	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_02845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CB4_02846	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CB4_02850	COG0174	glutamine synthetase
CB4_02851	COG0789	Transcriptional regulator
CB4_02852	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CB4_02857	COG0835	chemotaxis
CB4_02857	COG0784	Response regulator, receiver
CB4_02858	COG0464	growth
CB4_02859	COG2340	Cysteine-rich secretory protein family
CB4_02874	COG0436	Aminotransferase
CB4_02875	COG2011	ABC-type metal ion transport system permease component
CB4_02877	COG0726	polysaccharide deacetylase
CB4_02878	COG1923	regulation of RNA biosynthetic process
CB4_02879	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CB4_02880	COG2136	Putative SAM-dependent methyltransferase
CB4_02880	COG2521	methyltransferase
CB4_02884	COG1506	peptidase
CB4_02884	COG0823	Involved in the tonB-independent uptake of proteins
CB4_02884	COG4946	Tricorn protease homolog
CB4_02886	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CB4_02888	COG0726	polysaccharide deacetylase
CB4_02890	COG0840	transmembrane signaling receptor activity
CB4_02892	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_02894	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CB4_02898	COG1742	UPF0060 membrane protein
CB4_02899	COG2002	toxin-antitoxin pair type II binding
CB4_02902	COG1309	transcriptional regulator
CB4_02905	COG1971	Probably functions as a manganese efflux pump
CB4_02909	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CB4_02911	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CB4_02915	COG2378	regulation of single-species biofilm formation
CB4_02916	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CB4_02917	COG0765	amino acid transport
CB4_02918	COG1126	abc transporter atp-binding protein
CB4_02921	COG0840	transmembrane signaling receptor activity
CB4_02921	COG5278	phosphoserine phosphatase activity
CB4_02923	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CB4_02924	COG0785	Cytochrome C biogenesis protein
CB4_02925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB4_02926	COG0577	efflux transmembrane transporter activity
CB4_02927	COG1136	(ABC) transporter
CB4_02928	COG5002	protein histidine kinase activity
CB4_02930	COG0745	RESPONSE REGULATOR receiver
CB4_02940	COG1714	RDD family
CB4_02942	COG1714	RDD family
CB4_02950	COG2318	DinB family
CB4_02953	COG0179	Fumarylacetoacetate (FAA) hydrolase
CB4_02956	COG1846	Transcriptional regulator
CB4_02958	COG0583	DNA-binding transcription factor activity
CB4_02960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CB4_02965	COG0840	transmembrane signaling receptor activity
CB4_02972	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CB4_02973	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CB4_02981	COG0840	transmembrane signaling receptor activity
CB4_02981	COG3290	protein histidine kinase activity
CB4_02984	COG4550	Control of competence regulator ComK, YlbF/YmcA
CB4_02986	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CB4_02986	COG2205	protein histidine kinase activity
CB4_02988	COG2201	protein-glutamate methylesterase activity
CB4_02990	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CB4_02991	COG1234	tRNA 3'-trailer cleavage
CB4_02992	COG1013	pyruvate-flavodoxin oxidoreductase activity
CB4_02993	COG0674	pyruvate-flavodoxin oxidoreductase activity
CB4_02993	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CB4_02994	COG2359	stage V sporulation protein S
CB4_02996	COG2137	regulation of response to DNA damage stimulus
CB4_02997	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CB4_02999	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CB4_03000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CB4_03001	COG0513	Belongs to the DEAD box helicase family
CB4_03002	COG1546	Belongs to the CinA family
CB4_03002	COG1058	Belongs to the CinA family
CB4_03003	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CB4_03004	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CB4_03005	COG1426	Protein conserved in bacteria
CB4_03008	COG0300	oxidoreductase activity
CB4_03009	COG0612	Peptidase, M16
CB4_03010	COG0612	Peptidase, M16
CB4_03015	COG1566	PFAM secretion protein HlyD family protein
CB4_03016	COG2814	Major facilitator Superfamily
CB4_03019	COG0574	Belongs to the PEP-utilizing enzyme family
CB4_03019	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CB4_03020	COG1994	Peptidase M50
CB4_03022	COG3935	DnaD domain protein
CB4_03024	COG0436	Aminotransferase
CB4_03025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CB4_03029	COG0402	S-adenosylhomocysteine deaminase activity
CB4_03030	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CB4_03031	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CB4_03031	COG1199	ATP-dependent helicase activity
CB4_03035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CB4_03036	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CB4_03037	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CB4_03037	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CB4_03038	COG0617	tRNA 3'-terminal CCA addition
CB4_03039	COG0438	transferase activity, transferring glycosyl groups
CB4_03040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CB4_03041	COG1803	Methylglyoxal synthase
CB4_03042	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CB4_03043	COG1694	Mazg nucleotide pyrophosphohydrolase
CB4_03044	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_03056	COG1595	DNA-templated transcription, initiation
CB4_03059	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CB4_03060	COG0287	Prephenate dehydrogenase
CB4_03061	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CB4_03062	COG0159	tryptophan synthase activity
CB4_03064	COG0135	phosphoribosylanthranilate isomerase activity
CB4_03065	COG0134	indole-3-glycerol-phosphate synthase activity
CB4_03066	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CB4_03069	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CB4_03070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CB4_03071	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CB4_03072	COG0105	UTP biosynthetic process
CB4_03073	COG0142	geranyltranstransferase activity
CB4_03076	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CB4_03077	COG2226	methyltransferase
CB4_03078	COG0142	geranyltranstransferase activity
CB4_03082	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CB4_03087	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CB4_03088	COG1160	GTP binding
CB4_03092	COG0539	negative regulation of cytoplasmic translation
CB4_03094	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CB4_03096	COG2959	enzyme of heme biosynthesis
CB4_03098	COG2339	peptidase activity
CB4_03101	COG0492	ferredoxin-NADP+ reductase activity
CB4_03102	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CB4_03103	COG4862	establishment of competence for transformation
CB4_03104	COG2357	RelA SpoT domain protein
CB4_03105	COG0674	pyruvate-flavodoxin oxidoreductase activity
CB4_03107	COG0492	ferredoxin-NADP+ reductase activity
CB4_03111	COG0514	ATP-dependent DNA helicase (RecQ)
CB4_03112	COG4955	Helix-turn-helix domain
CB4_03113	COG1141	Ferredoxin
CB4_03119	COG1876	peptidase activity
CB4_03145	COG4626	Terminase
CB4_03145	COG1802	Transcriptional regulator
CB4_03149	COG2359	stage V sporulation protein S
CB4_03174	COG1525	nuclease
CB4_03179	COG0582	viral genome integration into host DNA
CB4_03183	COG1116	anion transmembrane transporter activity
CB4_03187	COG2205	protein histidine kinase activity
CB4_03189	COG1113	amino acid transport
CB4_03197	COG3655	Transcriptional regulator
CB4_03213	COG0598	Magnesium transport protein CorA
CB4_03218	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CB4_03220	COG0300	oxidoreductase activity
CB4_03221	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CB4_03222	COG2050	protein possibly involved in aromatic compounds catabolism
CB4_03223	COG5002	protein histidine kinase activity
CB4_03224	COG0745	RESPONSE REGULATOR receiver
CB4_03225	COG0824	Thioesterase
CB4_03228	COG5002	protein histidine kinase activity
CB4_03229	COG0745	RESPONSE REGULATOR receiver
CB4_03232	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CB4_03233	COG1333	cytochrome c biogenesis protein
CB4_03234	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB4_03236	COG1187	pseudouridine synthase activity
CB4_03237	COG0700	Nucleoside recognition
CB4_03238	COG2715	membrane protein required for spore maturation
CB4_03239	COG1686	Belongs to the peptidase S11 family
CB4_03240	COG1914	H( )-stimulated, divalent metal cation uptake system
CB4_03243	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CB4_03244	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CB4_03245	COG1994	Peptidase M50
CB4_03246	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CB4_03247	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CB4_03247	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CB4_03248	COG0307	riboflavin synthase, alpha
CB4_03249	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CB4_03249	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CB4_03250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CB4_03252	COG5278	phosphoserine phosphatase activity
CB4_03252	COG0840	transmembrane signaling receptor activity
CB4_03254	COG1201	RNA secondary structure unwinding
CB4_03259	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CB4_03260	COG3250	beta-galactosidase activity
CB4_03261	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CB4_03262	COG0579	oxidoreductase
CB4_03266	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CB4_03269	COG1176	ABC-type spermidine putrescine transport system, permease component I
CB4_03271	COG3842	ATPase activity
CB4_03272	COG0537	adenosine 5'-monophosphoramidase activity
CB4_03273	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CB4_03274	COG0019	diaminopimelate decarboxylase activity
CB4_03277	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_03282	COG2172	sigma factor antagonist activity
CB4_03284	COG1686	Belongs to the peptidase S11 family
CB4_03290	COG0384	phenazine biosynthesis protein PhzF
CB4_03291	COG4608	Belongs to the ABC transporter superfamily
CB4_03292	COG0444	Belongs to the ABC transporter superfamily
CB4_03293	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CB4_03294	COG0601	transmembrane transport
CB4_03295	COG4166	transmembrane transport
CB4_03296	COG0840	transmembrane signaling receptor activity
CB4_03300	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CB4_03301	COG4974	Belongs to the 'phage' integrase family
CB4_03305	COG0735	belongs to the Fur family
CB4_03306	COG1300	Membrane
CB4_03307	COG0494	nUDIX hydrolase
CB4_03310	COG2195	Cleaves the N-terminal amino acid of tripeptides
CB4_03312	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CB4_03313	COG0346	lactoylglutathione lyase activity
CB4_03315	COG0508	dehydrogenase complex catalyzes the overall conversion of
CB4_03316	COG0022	dehydrogenase e1 component
CB4_03317	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CB4_03318	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CB4_03319	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CB4_03320	COG3829	transcription factor binding
CB4_03320	COG3290	protein histidine kinase activity
CB4_03322	COG1215	transferase activity, transferring glycosyl groups
CB4_03325	COG0534	Mate efflux family protein
CB4_03329	COG0840	transmembrane signaling receptor activity
CB4_03330	COG4585	Histidine kinase
CB4_03331	COG2197	response regulator
CB4_03334	COG1253	flavin adenine dinucleotide binding
CB4_03335	COG2738	Putative neutral zinc metallopeptidase
CB4_03337	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CB4_03340	COG1595	DNA-templated transcription, initiation
CB4_03342	COG0726	polysaccharide deacetylase
CB4_03347	COG1012	belongs to the aldehyde dehydrogenase family
CB4_03350	COG0010	Belongs to the arginase family
CB4_03351	COG4848	Belongs to the UPF0354 family
CB4_03356	COG0180	Tryptophanyl-tRNA synthetase
CB4_03363	COG1392	Phosphate transport regulator
CB4_03364	COG0306	phosphate transporter
CB4_03367	COG2346	COG2346, Truncated hemoglobins
CB4_03369	COG0741	lytic transglycosylase activity
CB4_03370	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_03372	COG2154	pterin-4-alpha-carbinolamine dehydratase
CB4_03374	COG0784	Response regulator, receiver
CB4_03375	COG0784	Response regulator, receiver
CB4_03375	COG2205	protein histidine kinase activity
CB4_03375	COG5002	protein histidine kinase activity
CB4_03376	COG1744	ABC transporter substrate-binding protein PnrA-like
CB4_03377	COG2204	response regulator
CB4_03379	COG1309	transcriptional regulator
CB4_03386	COG0726	polysaccharide deacetylase
CB4_03388	COG1131	(ABC) transporter
CB4_03390	COG1388	LysM domain
CB4_03390	COG0791	NLP P60 protein
CB4_03391	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CB4_03392	COG0205	6-phosphofructokinase activity
CB4_03393	COG1940	carbohydrate kinase activity
CB4_03396	COG0840	transmembrane signaling receptor activity
CB4_03400	COG2208	phosphoserine phosphatase activity
CB4_03401	COG0477	Major facilitator Superfamily
CB4_03402	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_03403	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CB4_03404	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CB4_03405	COG2610	gluconate transmembrane transporter activity
CB4_03406	COG2204	response regulator
CB4_03409	COG2318	DinB family
CB4_03412	COG0454	-acetyltransferase
CB4_03416	COG4120	Belongs to the binding-protein-dependent transport system permease family
CB4_03418	COG0564	pseudouridine synthase activity
CB4_03419	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CB4_03423	COG4974	Belongs to the 'phage' integrase family
CB4_03425	COG3874	Sporulation protein YtfJ
CB4_03428	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CB4_03429	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CB4_03430	COG0531	amino acid
CB4_03431	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_03433	COG0861	Integral membrane protein TerC family
CB4_03434	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB4_03435	COG2258	MOSC domain
CB4_03436	COG0745	RESPONSE REGULATOR receiver
CB4_03437	COG5002	protein histidine kinase activity
CB4_03438	COG3706	GGDEF domain
CB4_03438	COG0745	RESPONSE REGULATOR receiver
CB4_03439	COG0788	formyltetrahydrofolate deformylase activity
CB4_03441	COG0561	phosphatase activity
CB4_03443	COG0004	ammonium transporteR
CB4_03446	COG2346	COG2346, Truncated hemoglobins
CB4_03448	COG2030	dehydratase
CB4_03453	COG3243	poly(R)-hydroxyalkanoic acid synthase
CB4_03454	COG0301	tRNA thio-modification
CB4_03455	COG1104	cysteine desulfurase activity
CB4_03459	COG1473	amidohydrolase
CB4_03460	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_03461	COG0300	oxidoreductase activity
CB4_03462	COG2155	Conserved Protein
CB4_03464	COG3069	C4-dicarboxylate transmembrane transporter activity
CB4_03470	COG0644	oxidoreductase
CB4_03471	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CB4_03475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CB4_03480	COG2081	HI0933 family
CB4_03482	COG3162	membrane
CB4_03483	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CB4_03484	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CB4_03485	COG1309	transcriptional regulator
CB4_03488	COG2203	Gaf domain
CB4_03488	COG2199	diguanylate cyclase activity
CB4_03489	COG0406	alpha-ribazole phosphatase activity
CB4_03490	COG0133	tryptophan synthase activity
CB4_03491	COG0697	spore germination
CB4_03492	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CB4_03493	COG0789	Transcriptional regulator
CB4_03494	COG2814	Major facilitator Superfamily
CB4_03495	COG0784	Response regulator, receiver
CB4_03495	COG3437	response regulator, receiver
CB4_03497	COG2197	response regulator
CB4_03498	COG0840	transmembrane signaling receptor activity
CB4_03499	COG4585	Histidine kinase
CB4_03500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CB4_03501	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CB4_03502	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_03503	COG0454	-acetyltransferase
CB4_03504	COG0517	IMP dehydrogenase activity
CB4_03505	COG0123	including yeast histone deacetylase and acetoin utilization protein
CB4_03508	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CB4_03508	COG1605	Chorismate mutase
CB4_03514	COG3118	belongs to the thioredoxin family
CB4_03515	COG0473	3-isopropylmalate dehydrogenase activity
CB4_03519	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB4_03520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CB4_03522	COG0517	IMP dehydrogenase activity
CB4_03523	COG0772	Belongs to the SEDS family
CB4_03524	COG0772	Belongs to the SEDS family
CB4_03525	COG2239	Acts as a magnesium transporter
CB4_03526	COG1285	pathogenesis
CB4_03534	COG3546	catalase activity
CB4_03535	COG0778	Nitroreductase
CB4_03536	COG3331	DNA recombination
CB4_03537	COG1547	Domain of unknown function (DUF309)
CB4_03538	COG0492	ferredoxin-NADP+ reductase activity
CB4_03555	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_03557	COG0410	ABC transporter
CB4_03560	COG0559	Belongs to the binding-protein-dependent transport system permease family
CB4_03564	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CB4_03567	COG0315	cyclic pyranopterin monophosphate synthase activity
CB4_03568	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CB4_03569	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CB4_03574	COG1674	ftsk spoiiie
CB4_03579	COG0129	dihydroxy-acid dehydratase activity
CB4_03580	COG1376	ErfK ybiS ycfS ynhG family protein
CB4_03581	COG0697	spore germination
CB4_03587	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB4_03588	COG1131	(ABC) transporter
CB4_03589	COG0842	Transport permease protein
CB4_03590	COG1309	transcriptional regulator
CB4_03591	COG1187	pseudouridine synthase activity
CB4_03593	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CB4_03595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CB4_03596	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CB4_03597	COG0602	queuosine metabolic process
CB4_03598	COG0720	synthase
CB4_03599	COG0483	inositol monophosphate 1-phosphatase activity
CB4_03600	COG2226	methyltransferase
CB4_03603	COG0861	Integral membrane protein TerC family
CB4_03605	COG0513	Belongs to the DEAD box helicase family
CB4_03606	COG0352	thiamine-phosphate diphosphorylase activity
CB4_03608	COG2104	thiamine diphosphate biosynthetic process
CB4_03609	COG2022	thiamine diphosphate biosynthetic process
CB4_03611	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CB4_03614	COG2814	Major facilitator Superfamily
CB4_03617	COG1242	4 iron, 4 sulfur cluster binding
CB4_03619	COG0513	Belongs to the DEAD box helicase family
CB4_03622	COG1278	Cold shock
CB4_03623	COG2267	carboxylic ester hydrolase activity
CB4_03625	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CB4_03627	COG1960	acyl-CoA dehydrogenase activity
CB4_03628	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CB4_03638	COG0583	DNA-binding transcription factor activity
CB4_03639	COG0840	transmembrane signaling receptor activity
CB4_03640	COG0726	polysaccharide deacetylase
CB4_03642	COG0778	Nitroreductase
CB4_03643	COG0840	transmembrane signaling receptor activity
CB4_03647	COG1556	Lactate utilization protein
CB4_03648	COG1139	Iron-sulfur cluster binding protein
CB4_03657	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CB4_03658	COG1024	Enoyl-CoA hydratase
CB4_03662	COG1024	Enoyl-CoA hydratase
CB4_03664	COG2050	protein possibly involved in aromatic compounds catabolism
CB4_03666	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_03667	COG1607	acyl-coa hydrolase
CB4_03670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CB4_03671	COG1879	ABC-type sugar transport system periplasmic component
CB4_03672	COG1172	Belongs to the binding-protein-dependent transport system permease family
CB4_03673	COG1129	ABC transporter
CB4_03674	COG1869	D-ribose catabolic process
CB4_03675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CB4_03676	COG1609	Transcriptional regulator
CB4_03681	COG0688	phosphatidylethanolamine metabolic process
CB4_03684	COG1832	CoA-binding protein
CB4_03686	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CB4_03687	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CB4_03688	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CB4_03689	COG2200	EAL domain
CB4_03690	COG0840	transmembrane signaling receptor activity
CB4_03695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CB4_03698	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CB4_03701	COG5583	Uncharacterized small protein (DUF2292)
CB4_03703	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CB4_03705	COG1484	DNA-dependent DNA replication
CB4_03706	COG3611	Membrane attachment protein
CB4_03707	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CB4_03708	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CB4_03709	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CB4_03710	COG0739	heme binding
CB4_03710	COG1196	nuclear chromosome segregation
CB4_03710	COG0741	lytic transglycosylase activity
CB4_03711	COG0237	dephospho-CoA kinase activity
CB4_03712	COG1971	Probably functions as a manganese efflux pump
CB4_03713	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CB4_03714	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CB4_03714	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CB4_03715	COG0330	HflC and HflK could
CB4_03716	COG5002	protein histidine kinase activity
CB4_03717	COG0745	RESPONSE REGULATOR receiver
CB4_03718	COG0039	L-malate dehydrogenase activity
CB4_03719	COG0538	isocitrate dehydrogenase activity
CB4_03720	COG0372	Belongs to the citrate synthase family
CB4_03721	COG0628	permease
CB4_03722	COG3030	protein affecting phage T7 exclusion by the F plasmid
CB4_03723	COG0824	Thioesterase
CB4_03725	COG0825	malonyl-CoA metabolic process
CB4_03726	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CB4_03727	COG2186	Transcriptional regulator
CB4_03728	COG0281	malic enzyme
CB4_03729	COG0587	DNA-directed DNA polymerase activity
CB4_03733	COG4948	Mandelate Racemase Muconate Lactonizing
CB4_03734	COG2311	Membrane
CB4_03735	COG1741	Belongs to the pirin family
CB4_03736	COG1846	Transcriptional regulator
CB4_03740	COG4109	DRTGG domain
CB4_03742	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CB4_03743	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CB4_03744	COG0189	ligase activity
CB4_03745	COG0189	ligase activity
CB4_03746	COG0189	ligase activity
CB4_03751	COG0436	Aminotransferase
CB4_03753	COG1683	Conserved Protein
CB4_03755	COG1937	Protein conserved in bacteria
CB4_03766	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB4_03767	COG3335	DDE superfamily endonuclease
CB4_03770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB4_03772	COG5002	protein histidine kinase activity
CB4_03773	COG3123	guanosine phosphorylase activity
CB4_03775	COG0737	Belongs to the 5'-nucleotidase family
CB4_03776	COG0737	Belongs to the 5'-nucleotidase family
CB4_03777	COG0494	nUDIX hydrolase
CB4_03778	COG0723	plastoquinol--plastocyanin reductase activity
CB4_03778	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CB4_03791	COG5002	protein histidine kinase activity
CB4_03793	COG0346	lactoylglutathione lyase activity
CB4_03795	COG3693	PFAM glycoside hydrolase, family 10
CB4_03796	COG2719	SpoVR family
CB4_03803	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CB4_03808	COG2719	SpoVR family
CB4_03816	COG1191	sigma factor activity
CB4_03820	COG2718	Belongs to the UPF0229 family
CB4_03821	COG2766	serine protein kinase
CB4_03824	COG1464	Belongs to the NlpA lipoprotein family
CB4_03828	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CB4_03829	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CB4_03830	COG0328	RNA-DNA hybrid ribonuclease activity
CB4_03831	COG0477	Major facilitator Superfamily
CB4_03832	COG2233	PERMEase
CB4_03833	COG1573	uracil-dna glycosylase
CB4_03834	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_03856	COG0735	belongs to the Fur family
CB4_03864	COG2096	Adenosyltransferase
CB4_03866	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CB4_03881	COG4555	ABC transporter
CB4_03882	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CB4_03883	COG0070	glutamate synthase
CB4_03883	COG0067	glutamate synthase
CB4_03883	COG0069	glutamate synthase activity
CB4_03884	COG4129	membrane
CB4_03885	COG1850	ribulose-bisphosphate carboxylase activity
CB4_03886	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CB4_03887	COG0235	Class ii aldolase
CB4_03888	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CB4_03889	COG2132	Multicopper oxidase
CB4_03892	COG1725	Transcriptional regulator
CB4_03893	COG1131	(ABC) transporter
CB4_03894	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CB4_03895	COG1132	(ABC) transporter
CB4_03896	COG3557	Belongs to the UPF0374 family
CB4_03899	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_03900	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_03904	COG0670	Belongs to the BI1 family
CB4_03908	COG1988	membrane-bound metal-dependent
CB4_03911	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CB4_03912	COG0534	Mate efflux family protein
CB4_03913	COG0529	Catalyzes the synthesis of activated sulfate
CB4_03914	COG2046	Belongs to the sulfate adenylyltransferase family
CB4_03915	COG0175	sulfate reduction
CB4_03916	COG0306	phosphate transporter
CB4_03918	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CB4_03920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CB4_03921	COG1012	belongs to the aldehyde dehydrogenase family
CB4_03922	COG3829	transcription factor binding
CB4_03922	COG3290	protein histidine kinase activity
CB4_03924	COG0840	transmembrane signaling receptor activity
CB4_03933	COG1183	phosphatidylcholine synthase activity
CB4_03934	COG1187	pseudouridine synthase activity
CB4_03937	COG2201	protein-glutamate methylesterase activity
CB4_03942	COG2199	diguanylate cyclase activity
CB4_03942	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_03944	COG0463	Glycosyl transferase, family 2
CB4_03945	COG0728	peptidoglycan biosynthetic process
CB4_03947	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CB4_03952	COG0438	transferase activity, transferring glycosyl groups
CB4_03956	COG1396	sequence-specific DNA binding
CB4_03969	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CB4_03984	COG0840	transmembrane signaling receptor activity
CB4_03990	COG2267	carboxylic ester hydrolase activity
CB4_03992	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB4_03993	COG4840	Belongs to the UPF0435 family
CB4_03994	COG0598	Magnesium transport protein CorA
CB4_03999	COG0840	transmembrane signaling receptor activity
CB4_04000	COG2011	ABC-type metal ion transport system permease component
CB4_04001	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CB4_04005	COG4715	Zinc finger, swim domain protein
CB4_04006	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CB4_04007	COG1132	(ABC) transporter
CB4_04009	COG1876	peptidase activity
CB4_04010	COG0501	Belongs to the peptidase M48B family
CB4_04019	COG1607	acyl-coa hydrolase
CB4_04021	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CB4_04023	COG0791	NLP P60 protein
CB4_04023	COG1388	LysM domain
CB4_04025	COG0667	Aldo Keto reductase
CB4_04026	COG0778	Nitroreductase
CB4_04027	COG1733	regulation of RNA biosynthetic process
CB4_04028	COG1522	sequence-specific DNA binding
CB4_04029	COG2814	Major facilitator Superfamily
CB4_04030	COG0531	amino acid
CB4_04038	COG3279	Response regulator of the LytR AlgR family
CB4_04039	COG0745	RESPONSE REGULATOR receiver
CB4_04039	COG2972	Histidine kinase
CB4_04068	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_04069	COG1794	racemase activity, acting on amino acids and derivatives
CB4_04072	COG4282	regulation of fungal-type cell wall biogenesis
CB4_04077	COG0582	viral genome integration into host DNA
CB4_04078	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CB4_04079	COG1597	lipid kinase activity
CB4_04080	COG0247	lactate metabolic process
CB4_04081	COG0277	FAD linked oxidase domain protein
CB4_04082	COG2186	Transcriptional regulator
CB4_04084	COG0194	GDP metabolic process
CB4_04087	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CB4_04088	COG0154	amidase activity
CB4_04089	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CB4_04090	COG5001	Diguanylate cyclase
CB4_04090	COG4251	negative regulation of phosphorylation
CB4_04090	COG3706	GGDEF domain
CB4_04090	COG2203	Gaf domain
CB4_04091	COG1396	sequence-specific DNA binding
CB4_04092	COG3384	dioxygenase
CB4_04093	COG2259	Doxx family
CB4_04098	COG0840	transmembrane signaling receptor activity
CB4_04099	COG2208	phosphoserine phosphatase activity
CB4_04102	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CB4_04103	COG0210	DNA helicase
CB4_04104	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CB4_04105	COG4496	protein, YerC YecD
CB4_04107	COG0386	Belongs to the glutathione peroxidase family
CB4_04110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_04112	COG0411	ABC transporter
CB4_04117	COG0151	Belongs to the GarS family
CB4_04119	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CB4_04120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CB4_04121	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CB4_04122	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CB4_04123	COG0047	phosphoribosylformylglycinamidine synthase activity
CB4_04124	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CB4_04125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CB4_04126	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CB4_04127	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CB4_04128	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CB4_04130	COG3437	response regulator, receiver
CB4_04131	COG0784	Response regulator, receiver
CB4_04131	COG2205	protein histidine kinase activity
CB4_04131	COG5002	protein histidine kinase activity
CB4_04132	COG2252	PERMEase
CB4_04133	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CB4_04133	COG0519	Catalyzes the synthesis of GMP from XMP
CB4_04134	COG0459	protein refolding
CB4_04135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CB4_04136	COG1823	symporter activity
CB4_04137	COG0521	Mo-molybdopterin cofactor biosynthetic process
CB4_04138	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CB4_04139	COG0488	(ABC) transporter
CB4_04140	COG0488	(ABC) transporter
CB4_04142	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CB4_04143	COG0840	transmembrane signaling receptor activity
CB4_04144	COG0840	transmembrane signaling receptor activity
CB4_04144	COG3290	protein histidine kinase activity
CB4_04145	COG0456	acetyltransferase
CB4_04146	COG1214	PFAM Peptidase M22, glycoprotease
CB4_04147	COG0802	atpase or kinase
CB4_04148	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CB4_04149	COG3091	SprT-like family
CB4_04152	COG2183	response to ionizing radiation
CB4_04153	COG2337	Toxic component of a toxin-antitoxin (TA) module
CB4_04154	COG0864	Transcriptional regulator
CB4_04155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CB4_04175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CB4_04176	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CB4_04176	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CB4_04177	COG0736	holo-[acyl-carrier-protein] synthase activity
CB4_04178	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_04181	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CB4_04182	COG1316	TRANSCRIPTIONal
CB4_04185	COG0463	Glycosyl transferase, family 2
CB4_04187	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CB4_04188	COG0785	Cytochrome C biogenesis protein
CB4_04189	COG2208	phosphoserine phosphatase activity
CB4_04190	COG1366	Belongs to the anti-sigma-factor antagonist family
CB4_04192	COG0840	transmembrane signaling receptor activity
CB4_04193	COG0643	Histidine kinase
CB4_04193	COG2198	Histidine kinase
CB4_04194	COG0835	chemotaxis
CB4_04195	COG1959	2 iron, 2 sulfur cluster binding
CB4_04196	COG2910	NAD(P)H-binding
CB4_04197	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CB4_04198	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity