locus-tag class description GFC30_100 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GFC30_1000 ENOG41080HI glycine oxidase GFC30_1002 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GFC30_1003 ENOG4105D06 uba thif-type nad fad binding protein GFC30_1006 ENOG4105DRP amino acid AbC transporter GFC30_1007 ENOG4105CDA abc transporter atp-binding protein GFC30_101 ENOG4105CTP PilT protein domain protein GFC30_1014 ENOG4108UH6 UPF0754 membrane protein GFC30_1015 ENOG4105WZB UPF0342 protein GFC30_1017 ENOG4105D4P Coproporphyrinogen iii oxidase GFC30_1019 ENOG4108IUX (ABC) transporter GFC30_102 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GFC30_1020 ENOG4105RHA ABC transporter, permease GFC30_1021 ENOG4105EQI Metal Dependent Phosphohydrolase GFC30_1023 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GFC30_1026 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) GFC30_1028 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GFC30_1029 ENOG4105K59 histidine triad (HIT) protein GFC30_1033 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GFC30_1036 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GFC30_1037 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GFC30_1038 ENOG4105C1Q protoporphyrinogen oxidase GFC30_104 ENOG41066A3 ATP guanido phosphotransferase GFC30_1040 ENOG4105ECB domain protein GFC30_1042 ENOG4107T3P ABC, transporter GFC30_1045 ENOG4106AXD GFC30_1047 ENOG4108RQ5 Beta-lactamase domain-containing protein GFC30_1048 ENOG4105CEY Amp-dependent synthetase and ligase GFC30_105 ENOG4108Z0C Uvrb UvrC protein GFC30_1050 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GFC30_1053 ENOG4105XVF Competence transcription factor GFC30_1056 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination GFC30_1057 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GFC30_1059 ENOG4105EYH Exonuclease GFC30_1069 ENOG4105CEY Amp-dependent synthetase and ligase GFC30_1071 ENOG4105ERH Fumarylacetoacetate hydrolase GFC30_1072 ENOG4105C8Y Acetylornithine aminotransferase GFC30_1073 ENOG4105YHS UPF0344 protein GFC30_1075 ENOG4105CAQ asparagine synthetase GFC30_1076 ENOG4105UQX Mate efflux family protein GFC30_1077 ENOG4106HBX Transcriptional Regulator AraC Family GFC30_1079 ENOG4107FKK extracellular solute-binding protein family 1 GFC30_1081 ENOG4105EG2 ABC transporter, permease GFC30_1082 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GFC30_1083 ENOG4105ETE Transcriptional regulator (LacI family GFC30_1084 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GFC30_1087 ENOG4108VPT UPF0234 protein GFC30_1088 ENOG4105QNR S1 RNA binding domain protein GFC30_1090 ENOG4105DIH basic membrane GFC30_1091 ENOG4105C8Q Methyl-accepting chemotaxis GFC30_1094 ENOG4105EPR degv family GFC30_1095 ENOG4107AYK membrAne GFC30_1098 ENOG4108KP7 hydrolase GFC30_1099 ENOG4108MXZ Esterase GFC30_1100 ENOG4105VG1 fes assembly suf system protein GFC30_1104 ENOG4107V6Q Cyclic nucleotide-binding domain GFC30_1105 ENOG4105DSQ Nitric oxide reductase GFC30_111 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GFC30_1117 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GFC30_1118 ENOG4108BB0 Elp3 GFC30_1120 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GFC30_1121 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GFC30_1122 ENOG4105CVM Molybdenum cofactor synthesis domain protein GFC30_1124 ENOG4108ZAF Molybdopterin GFC30_1127 ENOG4107V6Q Cyclic nucleotide-binding domain GFC30_1128 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GFC30_1129 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GFC30_113 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GFC30_1130 ENOG4105CAS nag kinase GFC30_1134 ENOG4105DBV ornithine carbamoyltransferase GFC30_1136 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GFC30_114 ENOG4105KRF dihydroneopterin aldolase GFC30_1140 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GFC30_1141 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GFC30_1144 ENOG4108KU1 UPF0736 protein GFC30_1146 ENOG4108J59 Extracellular solute-binding protein, family 5 GFC30_1147 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC30_1148 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC30_1149 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GFC30_115 ENOG4105EEI dihydropteroate synthase GFC30_1151 ENOG4108JQ7 (ABC) transporter GFC30_1153 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GFC30_1154 ENOG4108ZCF integral membrane protein GFC30_1156 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GFC30_1158 ENOG4105DPN Oligoendopeptidase f GFC30_116 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GFC30_1160 ENOG4105T58 Dithiol-disulfide isomerase GFC30_1161 ENOG4108Z18 K06886 hemoglobin GFC30_1162 ENOG4105E4C Lytic transglycosylase catalytic GFC30_1163 ENOG4105MIX Adenylate cyclase GFC30_1164 ENOG4106EFP UPF0738 protein GFC30_1166 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GFC30_1167 ENOG4107S1Q Phosphatase GFC30_1168 ENOG4105EMS pseudouridine synthase GFC30_117 ENOG4105DDQ anthranilate synthase GFC30_1172 ENOG4108KS4 Spore coat protein GFC30_1173 ENOG4107SBE Glycosyl transferase (Group 1 GFC30_1174 ENOG4107SBE Glycosyl transferase (Group 1 GFC30_1175 ENOG4108IAJ Nad-dependent epimerase dehydratase GFC30_118 ENOG4105CRQ synthase (Component I) GFC30_1187 ENOG41090VF Stage v sporulation protein ac GFC30_1188 ENOG4105CZ3 stage V sporulation protein ad GFC30_119 ENOG4105C6T cysteine synthase GFC30_1191 ENOG4108QY0 Membrane GFC30_1193 ENOG4105SZ6 Thioredoxin GFC30_1197 ENOG4105ENA helicase GFC30_1199 ENOG4108ZMI UPF0477 protein GFC30_120 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GFC30_1201 ENOG4105C28 cystathionine GFC30_1202 ENOG4105C28 cystathionine GFC30_1207 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GFC30_1208 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GFC30_121 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GFC30_1210 ENOG4105E0C molybdate abc transporter GFC30_1211 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GFC30_1212 ENOG4108IMY Transcriptional regulator GFC30_1213 ENOG4105HDK L-asparaginase GFC30_1214 ENOG4108IJ0 Aspartate ammonia-lyase GFC30_1217 ENOG4105DUM transcriptional regulator, lysR family GFC30_1219 ENOG4105XXY Thioredoxin GFC30_122 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GFC30_1221 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GFC30_1222 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GFC30_1223 ENOG4105DWK Membrane GFC30_1227 ENOG4105DTQ mandelate racemase muconate lactonizing GFC30_1228 ENOG4105CUB amino acid GFC30_123 ENOG4108UGV hypoxanthine phosphoribosyltransferase GFC30_1231 ENOG4105CUB amino acid GFC30_1233 ENOG410681C small acid-soluble spore protein GFC30_1234 ENOG4105C8Q Methyl-accepting chemotaxis GFC30_1236 ENOG4105CVA phosphate GFC30_1237 ENOG4105C8U phosphate abc transporter GFC30_1238 ENOG4105E2Z phosphate ABC transporter (Permease GFC30_124 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GFC30_1240 ENOG4105ETE Transcriptional regulator (LacI family GFC30_1245 ENOG4105DRS transport system, permease GFC30_1251 ENOG4105BZU Histidine kinase GFC30_1252 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GFC30_1254 ENOG4107SDZ Galactoside transport system permease protein mglC GFC30_1255 ENOG4105C2J ABC transporter GFC30_1256 ENOG4105FCA ABC transporter periplasmic-binding protein YphF GFC30_1257 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GFC30_1259 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GFC30_1260 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GFC30_1262 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GFC30_1263 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) GFC30_1264 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GFC30_1265 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GFC30_1266 ENOG41090MY MarR family Transcriptional regulator GFC30_1267 ENOG4105D5Q Arginine ornithine antiporter GFC30_1268 ENOG4105CJ1 ABC, transporter GFC30_1273 ENOG4108K88 Membrane GFC30_1277 ENOG4108B31 Spore germination protein GFC30_1278 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GFC30_1279 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase GFC30_1280 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GFC30_1281 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GFC30_1285 ENOG4106FBB RNA Polymerase GFC30_1289 ENOG4105BZU Histidine kinase GFC30_1294 ENOG4105BZU Histidine kinase GFC30_1295 ENOG4107RWR Sodium hydrogen exchanger GFC30_1297 ENOG4105CID antiterminator GFC30_130 ENOG41060GV RNA binding s1 domain protein GFC30_1302 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GFC30_1303 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GFC30_1304 ENOG4105YB8 TM2 domain containing protein GFC30_1305 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GFC30_1307 ENOG4105CHR reductase GFC30_1308 ENOG4105CEY Amp-dependent synthetase and ligase GFC30_1309 ENOG4105U5Y Transcriptional regulator GFC30_1312 ENOG4108N5B 2-phosphosulfolactate phosphatase GFC30_1313 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GFC30_1315 ENOG4105CHM Aminotransferase GFC30_1317 ENOG4105D7N magnesium and cobalt transport protein CorA GFC30_1322 ENOG4108HGU Histidine kinase GFC30_1324 ENOG4107R88 Chemotaxis protein (CheV) GFC30_1325 ENOG4105BZU Histidine kinase GFC30_1327 ENOG4107QJZ Glycosyl transferase, family 2 GFC30_1329 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC30_1330 ENOG4105BZU Histidine kinase GFC30_1331 ENOG4105E1K spore germination protein GFC30_1332 ENOG4108B31 Spore germination protein GFC30_1334 ENOG4105UIN GFC30_1336 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GFC30_1338 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GFC30_1339 ENOG4105EPM Diguanylate phosphodiesterase GFC30_134 ENOG4105VYY sporulation protein yabp GFC30_1341 ENOG4107IN1 Protein of unknown function (DUF1797) GFC30_1345 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GFC30_1346 ENOG4105CH2 amidohydrolase GFC30_1347 ENOG4106AUC UPF0180 protein GFC30_1349 ENOG4105CN5 Metallo-Beta-Lactamase GFC30_135 ENOG41082I2 s4 domain protein GFC30_1350 ENOG4106148 UPF0356 protein GFC30_1351 ENOG4108X4Q Hydrolase GFC30_136 ENOG4108IY2 MazG family GFC30_1362 ENOG4105CXN decarboxylase GFC30_1363 ENOG4105EA8 2-Nitropropane dioxygenase GFC30_1364 ENOG4105WBI UPF0223 protein GFC30_1366 ENOG4105ECY inositol monophosphatase GFC30_1368 ENOG4105CI3 gtp-binding protein typa GFC30_1369 ENOG4105QA2 GFC30_1374 ENOG4108IAB Phoh family GFC30_1376 ENOG4105ZPI UPF0358 protein GFC30_1377 ENOG4105CNI cell division protein FtsW GFC30_1378 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GFC30_138 ENOG4108M14 stage v sporulation protein t GFC30_1380 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GFC30_1381 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GFC30_139 ENOG4108JA2 transcriptioN-repair coupling factor GFC30_1390 ENOG4105K4I Scp-like extracellular GFC30_1391 ENOG41080XQ Signal transduction protein with cbs domains GFC30_1393 ENOG4106UY4 Inherit from COG: Scp-like extracellular GFC30_1398 ENOG4105WUC UPF0298 protein GFC30_1401 ENOG4106H78 methyltransferase GFC30_1402 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GFC30_1403 ENOG4105H20 Sporulation integral membrane protein YlbJ GFC30_1404 ENOG4105D78 K07001 NTE family protein GFC30_1405 ENOG41063PX domain protein GFC30_1406 ENOG4105CDE UPF0348 protein GFC30_1407 ENOG4105KNH Nucleic acid-binding protein GFC30_1408 ENOG4105E39 Enoyl-CoA hydratase GFC30_141 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GFC30_1412 ENOG41074B2 UPF0747 protein GFC30_1413 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GFC30_1414 ENOG41068DC Essential cell division protein (By similarity) GFC30_1415 ENOG4105CJN penicillin-binding protein GFC30_1416 ENOG4105CJN penicillin-binding protein GFC30_1417 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GFC30_1418 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GFC30_1419 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GFC30_142 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GFC30_1420 ENOG4105CNI cell division protein FtsW GFC30_1421 ENOG4105D4A Cell wall formation (By similarity) GFC30_1422 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GFC30_1423 ENOG4108R2U division initiation protein GFC30_1425 ENOG4105K67 small basic protein GFC30_1426 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GFC30_1427 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GFC30_1428 ENOG4108AWX Sporulation factor SpoIIGA GFC30_1429 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC30_1431 ENOG4105WR5 sporulation protein, YlmC YmxH family GFC30_1432 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GFC30_1433 ENOG4105DFA alanine racemase domain protein GFC30_1434 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GFC30_1435 ENOG41067XK integral membrane protein GFC30_1436 ENOG4105DBK s4 domain protein GFC30_1438 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GFC30_1439 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GFC30_144 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GFC30_1440 ENOG4105C34 Pseudouridine synthase GFC30_1441 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GFC30_1443 ENOG4105CXT aspartate transcarbamylase GFC30_1444 ENOG4105CD3 dihydroorotase GFC30_1447 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GFC30_1448 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GFC30_1449 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GFC30_145 ENOG4105K4W Could be involved in septation (By similarity) GFC30_1457 ENOG4105F23 Fibronectin-binding protein GFC30_1459 ENOG4105DSJ YicC domain protein GFC30_146 ENOG4105KME endoribonuclease L-psp GFC30_1460 ENOG4105KC4 UPF0296 protein GFC30_1461 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GFC30_1462 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GFC30_1463 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GFC30_1464 ENOG4105C25 Primosomal protein n' GFC30_1465 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GFC30_1466 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GFC30_1467 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GFC30_1468 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GFC30_1469 ENOG4108ZF3 Phosphatase GFC30_147 ENOG4105DFT pur operon repressor GFC30_1470 ENOG4105D9P serine threonine protein kinase GFC30_1471 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GFC30_1472 ENOG4105DJV ribulose-phosphate 3-epimerase GFC30_1473 ENOG4105FJ0 thiamine GFC30_1474 ENOG4105VB9 50S ribosomal protein l28 GFC30_1475 ENOG4108ZAA Alkaline-shock protein GFC30_1476 ENOG4105DP4 dak2 domain fusion protein ylov GFC30_1478 ENOG4105EJQ L-serine dehydratase GFC30_1479 ENOG4105CB5 ATP-dependent DNA helicase recG GFC30_148 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GFC30_1480 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GFC30_1481 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GFC30_1482 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GFC30_1483 ENOG4105CHR reductase GFC30_1484 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GFC30_1485 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GFC30_1486 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GFC30_1487 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GFC30_1488 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GFC30_1490 ENOG4105K5M 30s ribosomal protein S16 GFC30_1491 ENOG4105VB6 UPF0109 protein GFC30_1493 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GFC30_1494 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GFC30_1495 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GFC30_1497 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GFC30_1498 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GFC30_150 ENOG4105W42 Veg protein GFC30_1500 ENOG4105D00 flagellar biosynthetic protein flhB GFC30_1501 ENOG4105CMV Succinyl-CoA synthetase subunit beta GFC30_1502 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GFC30_1503 ENOG4105C79 DNA protecting protein DprA GFC30_1504 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GFC30_1505 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GFC30_1506 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC30_1507 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GFC30_1508 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GFC30_1509 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) GFC30_151 ENOG4105XFA sporulation peptidase YabG GFC30_1510 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GFC30_1511 ENOG4108ZC9 flagellar basal-body rod protein flgc GFC30_1512 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GFC30_1513 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GFC30_1514 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GFC30_1517 ENOG4106YF4 Flagellar biosynthesis chaperone GFC30_1519 ENOG410696Y Flagellar hook-length control protein GFC30_152 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GFC30_1520 ENOG410822I Flagellar hook capping protein GFC30_1521 ENOG4108JQA flagellar GFC30_1523 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GFC30_1524 ENOG4105DD5 Flagellar motor switch protein GFC30_1525 ENOG4107YTP response regulator receiver protein GFC30_1527 ENOG4105CN7 Flagellar biosynthetic protein FliP GFC30_1528 ENOG4105VS8 Flagellar biosynthetic protein fliq GFC30_1529 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GFC30_153 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GFC30_1530 ENOG4105D00 flagellar biosynthetic protein flhB GFC30_1531 ENOG4105D7B Flagellar biosynthesis protein flha GFC30_1532 ENOG4105FZW flagellar biosynthesis regulator FlhF GFC30_1534 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GFC30_1535 ENOG4105CBS Chea signal transduction histidine kinase GFC30_1536 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis GFC30_1538 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GFC30_154 ENOG4105D7V transposase GFC30_1540 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC30_1543 ENOG4105CE9 30S ribosomal protein S2 GFC30_1544 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GFC30_1545 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GFC30_1546 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GFC30_1547 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GFC30_1548 ENOG4105KNE Phosphatidate cytidylyltransferase GFC30_1549 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GFC30_1550 ENOG4105DZP Membrane-associated zinc metalloprotease GFC30_1551 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GFC30_1552 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GFC30_1553 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GFC30_1554 ENOG4105CHV Transcription elongation factor NusA GFC30_1555 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GFC30_1556 ENOG4105VHM ribosomal protein GFC30_1557 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GFC30_1558 ENOG4105W7A Protein of unknown function (DUF503) GFC30_1559 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GFC30_156 ENOG41069ER domain protein GFC30_1560 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GFC30_1561 ENOG4105DTN riboflavin biosynthesis protein ribF GFC30_1562 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GFC30_1563 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GFC30_1565 ENOG4105C1V Peptidase, M16 GFC30_1567 ENOG4105E35 Dipicolinate synthase subunit A GFC30_1568 ENOG4108S0H Dipicolinic acid synthetase, b subunit GFC30_1569 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GFC30_157 ENOG4105F8V Hydrolase, tatD family GFC30_1571 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GFC30_1573 ENOG4105EKQ RNA-directed DNA polymerase GFC30_1574 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GFC30_1576 ENOG4105CNU cell division protein FtsK GFC30_1577 ENOG4105FDP GntR family transcriptional regulator GFC30_1578 ENOG4105DIH basic membrane GFC30_1579 ENOG4108JQ9 ABC transporter GFC30_1580 ENOG4105UIB (ABC) transporter GFC30_1584 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GFC30_1585 ENOG4105XZV Protein of unknown function (DUF3243) GFC30_1588 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GFC30_1589 ENOG4105CEV competence damage-inducible protein GFC30_159 ENOG4105KRN Transcriptional regulator, abrb family GFC30_1590 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GFC30_1592 ENOG4105D7V transposase GFC30_1593 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GFC30_1594 ENOG4105D48 metallophosphoesterase GFC30_1595 ENOG4105MCT stage V sporulation protein S GFC30_1596 ENOG4108IGT Dipeptidase GFC30_1597 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GFC30_1598 ENOG4105DQU oxidoreductase, subunit beta GFC30_1599 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GFC30_160 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GFC30_1602 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GFC30_1603 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GFC30_1604 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC30_1605 ENOG4105C8Q Methyl-accepting chemotaxis GFC30_1606 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GFC30_1607 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GFC30_1608 ENOG4106F1P AAA ATPase, central domain protein GFC30_161 ENOG41060K3 Methyltransferase GFC30_1610 ENOG4105C1G acyl-Coa dehydrogenase GFC30_1611 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GFC30_1612 ENOG4105CEY Amp-dependent synthetase and ligase GFC30_1613 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC30_1614 ENOG4105CHU acetyl-coa acetyltransferase GFC30_1615 ENOG4105EN6 Membrane GFC30_1616 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GFC30_1617 ENOG4105CXI aluminum resistance protein GFC30_1618 ENOG4105KV4 Transcriptional regulator GFC30_1619 ENOG4105C5F glutamine synthetase GFC30_162 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) GFC30_1620 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GFC30_1621 ENOG41067Z0 domain protein GFC30_1622 ENOG4108SVB resolvase GFC30_1623 ENOG4105VPS UPF0291 protein GFC30_1626 ENOG4105VXM UPF0154 protein GFC30_1627 ENOG4105BZ1 (ABC) transporter GFC30_1628 ENOG4105BZ1 (ABC) transporter GFC30_163 ENOG4105MA4 psp1 domain protein GFC30_1630 ENOG4107QIV Cytochrome c biogenesis protein GFC30_1631 ENOG4107YTP response regulator receiver protein GFC30_1634 ENOG4105F0V Cell wall hydrolase GFC30_1635 ENOG4107DZX Small, acid-soluble spore protein P GFC30_1637 ENOG410746C Acid-soluble spore protein O GFC30_1638 ENOG4108I0Z Aconitate hydratase GFC30_164 ENOG4105FA2 dna polymerase iii GFC30_165 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GFC30_1650 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GFC30_1651 ENOG4105BZU Histidine kinase GFC30_1652 ENOG4105C8Q Methyl-accepting chemotaxis GFC30_1653 ENOG4107R7I amino acid GFC30_1654 ENOG4105CUB amino acid GFC30_1655 ENOG4107QJZ Glycosyl transferase, family 2 GFC30_1657 ENOG4105WMR Protein CrcB homolog GFC30_1658 ENOG4105WMR Protein CrcB homolog GFC30_1659 ENOG4108ZJ4 polysaccharide deacetylase GFC30_166 ENOG4105CXN decarboxylase GFC30_1660 ENOG4105ETE Transcriptional regulator (LacI family GFC30_1664 ENOG4108HKT sucrose-6-phosphate hydrolase GFC30_1665 ENOG4105CG3 alpha amylase, catalytic region GFC30_1677 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein GFC30_1678 ENOG4105C32 Amino acid ABC transporter (Permease) GFC30_1680 ENOG4105C0Z ABC transporter GFC30_1681 ENOG4108IV0 ABC, transporter GFC30_1682 ENOG4108YZ9 Urea amidohydrolase subunit gamma GFC30_1683 ENOG4105KI2 Urea amidohydrolase subunit beta GFC30_1684 ENOG4105CQM Urea amidohydrolase subunit alpha GFC30_1685 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) GFC30_1686 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GFC30_1691 ENOG4105BZU Histidine kinase GFC30_1692 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC30_1697 ENOG4105VPX protein, conserved in bacteria GFC30_1698 ENOG4105C59 p-type ATPase GFC30_17 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GFC30_1700 ENOG4107R16 Multicopper oxidase GFC30_1704 ENOG4107RUY (E1 component), alpha subunit GFC30_1705 ENOG4105CPP Dehydrogenase, E1 component GFC30_1706 ENOG4105CQB FAD linked oxidase domain protein GFC30_1708 ENOG4105ETD TRANSCRIPTIONal GFC30_1710 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GFC30_1716 ENOG4105C01 Dihydroxy-acid dehydratase GFC30_1718 ENOG4105DQF Hydrolase GFC30_1720 ENOG4105J7I hydrolase GFC30_1721 ENOG4105BZJ Electron transfer flavoprotein GFC30_1722 ENOG4105C10 Electron transfer flavoprotein GFC30_1723 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GFC30_1724 ENOG41090P5 ferredoxin-like protein GFC30_1729 ENOG4108MES Periplasmic binding protein GFC30_1730 ENOG4105DQ5 transport system permease protein GFC30_1731 ENOG4108IHU transport system permease protein GFC30_1732 ENOG4105E0A ABC, transporter GFC30_1734 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GFC30_1735 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GFC30_1739 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit GFC30_1740 ENOG4105WGB oxidoreductase, delta subunit GFC30_1741 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC30_1742 ENOG4108JPZ Monovalent cation H antiporter subunit D GFC30_1744 ENOG4107TDF Formate hydrogenlyase subunit 4 GFC30_1745 ENOG4108JPZ Monovalent cation H antiporter subunit D GFC30_1746 ENOG4105C28 cystathionine GFC30_1749 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GFC30_1751 ENOG4105C26 Dehydrogenase GFC30_1753 ENOG4108IV0 ABC, transporter GFC30_1757 ENOG4105DZS Phenylacetate-CoA ligase GFC30_1758 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GFC30_1761 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GFC30_1763 ENOG4105E39 Enoyl-CoA hydratase GFC30_1764 ENOG4108UKI Enoyl-CoA hydratase GFC30_1765 ENOG4105C26 Dehydrogenase GFC30_1766 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC30_1767 ENOG4105CHU acetyl-coa acetyltransferase GFC30_1768 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein GFC30_1769 ENOG4108Z0R Transferase GFC30_177 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GFC30_1770 ENOG4105EA8 2-Nitropropane dioxygenase GFC30_1775 ENOG4105C7S Dehydrogenase GFC30_178 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GFC30_1783 ENOG4105CDW Resistance protein GFC30_179 ENOG4105C6E dna polymerase iii GFC30_1790 ENOG4105BZU Histidine kinase GFC30_1791 ENOG4105CVJ phosphoglycerate mutase GFC30_1792 ENOG4105CE1 Ferrous iron transport protein b GFC30_1793 ENOG4105CE1 Ferrous iron transport protein b GFC30_1794 ENOG4105CE1 Ferrous iron transport protein b GFC30_1795 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GFC30_1797 ENOG4105CEY Amp-dependent synthetase and ligase GFC30_1798 ENOG4105CSU acyl-Coa dehydrogenase GFC30_1799 ENOG4108UT2 hemolysin iii GFC30_18 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GFC30_180 ENOG4108Z6B deaminase GFC30_1802 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GFC30_1803 ENOG4105P4J Allophanate hydrolase, subunit 1 GFC30_1805 ENOG4105E7W lamb ycsf family protein GFC30_1808 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GFC30_1809 ENOG4105DWF phosphomethylpyrimidine kinase GFC30_181 ENOG4105VRS hydrolase family 18 GFC30_1811 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GFC30_1812 ENOG4108IQI permease GFC30_1813 ENOG4108JYZ YitT family GFC30_1814 ENOG4105DUX Transporter GFC30_1816 ENOG4107Y9E nuclease GFC30_1817 ENOG4105BZU Histidine kinase GFC30_1819 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC30_1820 ENOG4105BZU Histidine kinase GFC30_1822 ENOG4105C6T cysteine synthase GFC30_1824 ENOG4108UKS UPF0398 protein GFC30_1825 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) GFC30_1826 ENOG4105BZU Histidine kinase GFC30_1827 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GFC30_1829 ENOG4105DVT helicase GFC30_183 ENOG4105ZMH deoxynucleoside kinase GFC30_1830 ENOG4105CTD carboxy-peptidase GFC30_1831 ENOG4107RQ2 Cytochrome c oxidase, subunit I GFC30_1832 ENOG4105NAA Cytochrome C oxidase, subunit II GFC30_1834 ENOG41065KQ synthase GFC30_1836 ENOG410890F Dynamin family GFC30_1838 ENOG4105KHC sulfurtransferase GFC30_1840 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC30_1842 ENOG41075ZD Small, acid-soluble spore protein N GFC30_1843 ENOG41067CD Small, acid-soluble spore protein Tlp GFC30_1845 ENOG4105MI2 GFC30_1846 ENOG4105KA0 thioesterase Superfamily protein GFC30_1847 ENOG4105W8X HesB YadR YfhF-family protein GFC30_1852 ENOG4105D7V transposase GFC30_1853 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GFC30_1854 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GFC30_1857 ENOG4107S4Y M20 DapE family protein YgeY GFC30_1858 ENOG4108TSC N-acetyltransferase GFC30_1859 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GFC30_186 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GFC30_1861 ENOG4105VSD UPF0346 protein GFC30_1867 ENOG4105G0J serine threonine protein kinase GFC30_1868 ENOG4108N23 SpoOM-related protein GFC30_187 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GFC30_1870 ENOG4106Z5R GFC30_1874 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GFC30_1875 ENOG4108VXD carboxy-peptidase GFC30_1877 ENOG4105D7N magnesium and cobalt transport protein CorA GFC30_1878 ENOG4105FR1 rard protein GFC30_188 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GFC30_1881 ENOG4107QMU Mate efflux family protein GFC30_1882 ENOG4105BZU Histidine kinase GFC30_1885 ENOG4105E5W Transporter GFC30_1886 ENOG4105C7B Threonine dehydratase GFC30_1891 ENOG4108WS4 fmn reductase GFC30_1892 ENOG4105U5Y Transcriptional regulator GFC30_1893 ENOG4105C1G acyl-Coa dehydrogenase GFC30_1894 ENOG4105CEY Amp-dependent synthetase and ligase GFC30_1895 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GFC30_1896 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GFC30_1897 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GFC30_1898 ENOG4105E39 Enoyl-CoA hydratase GFC30_1899 ENOG4107QX3 carboxylase GFC30_19 ENOG4108TYN CAAX amino terminal protease family protein GFC30_190 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GFC30_1901 ENOG4105CW7 secretion protein, HlyD family GFC30_1902 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC30_1910 ENOG4108UZ3 Transporter GFC30_1912 ENOG4108UZ3 Transporter GFC30_1913 ENOG4108HGU Histidine kinase GFC30_1914 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GFC30_1915 ENOG4105DVE abc transporter atp-binding protein GFC30_1920 ENOG4105E1K spore germination protein GFC30_1923 ENOG4108MJI response regulator GFC30_1927 ENOG4105BZ1 (ABC) transporter GFC30_1928 ENOG4105BZ1 (ABC) transporter GFC30_1929 ENOG4108RPX mosc domain containing protein GFC30_1931 ENOG4105VEQ Cold shock protein GFC30_1934 ENOG4108NNI Beta-lactamase domain-containing protein GFC30_1935 ENOG41090WU lipolytic protein G-D-S-L family GFC30_1936 ENOG4105CJ1 ABC, transporter GFC30_1937 ENOG4108TU7 Inherit from COG: (ABC) transporter GFC30_1942 ENOG41082BM Transcriptional regulator, arsr family GFC30_1944 ENOG4105N14 lysine exporter protein LysE YggA GFC30_1945 ENOG4105C1G acyl-Coa dehydrogenase GFC30_1946 ENOG4105CHR reductase GFC30_1950 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GFC30_1951 ENOG4105C7S Dehydrogenase GFC30_1952 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GFC30_1955 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin GFC30_1956 ENOG4105C0D helicase GFC30_1957 ENOG4107QMH DNA methylase GFC30_1986 ENOG4107QJE Chromosome Partitioning Protein GFC30_1989 ENOG4105D7V transposase GFC30_1991 ENOG4107ZXU DSBA oxidoreductase GFC30_1995 ENOG4105EEM helicase GFC30_1998 ENOG4105EPW hflc protein GFC30_1999 ENOG4107QJR hflk protein GFC30_20 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GFC30_200 ENOG4105CPI Metal Dependent Phosphohydrolase GFC30_2003 ENOG4108ZMX Domain of unknown function (DU1801) GFC30_2005 ENOG41086VY Fic/DOC family GFC30_2008 ENOG41082YX Transcriptional regulator, arsr family GFC30_2009 ENOG4107R5R arsenical pump membrane protein GFC30_201 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC30_2010 ENOG4108UXE Protein tyrosine phosphatase GFC30_2014 ENOG4105DKW ABC transporter GFC30_202 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC30_2020 ENOG4106U2H Protein of unknown function (DUF1360) GFC30_2021 ENOG4105C9U ATP-dependent DNA helicase RecQ GFC30_2022 ENOG4108Z7R Chaperone CsaA GFC30_2028 ENOG4105CVR type I restriction-modification system GFC30_203 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GFC30_2039 ENOG4105D9P serine threonine protein kinase GFC30_204 ENOG410848D S4 domain protein YaaA GFC30_2042 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GFC30_2045 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GFC30_2047 ENOG4105C4M (Ubiquinol oxidase) subunit I GFC30_2048 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GFC30_2049 ENOG4108JJ9 ABC, transporter GFC30_205 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GFC30_2050 ENOG4108JJ8 (ABC) transporter GFC30_2053 ENOG4107X35 defense response to bacterium GFC30_2055 ENOG4107T89 von Willebrand factor, type A GFC30_2056 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GFC30_2058 ENOG4105CIY formyltetrahydrofolate deformylase GFC30_2059 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GFC30_206 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GFC30_2060 ENOG4105KPV Transcriptional regulator GFC30_2061 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GFC30_2062 ENOG4105FDT acyl-CoA dehydrogenase GFC30_2063 ENOG4107S6Z Na H antiporter GFC30_2064 ENOG4107414 GntR family transcriptional regulator GFC30_2065 ENOG4105CG3 alpha amylase, catalytic region GFC30_2066 ENOG4105C5Y PTS System GFC30_2067 ENOG4105C5Y PTS System GFC30_207 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GFC30_2070 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC30_2071 ENOG4105K4P CoA-binding domain protein GFC30_2073 ENOG4108WZW RNA polymerase sigma GFC30_2076 ENOG4105H67 Protein of unknown function (DUF421) GFC30_2078 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GFC30_2079 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GFC30_208 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GFC30_2080 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GFC30_2082 ENOG41090WU lipolytic protein G-D-S-L family GFC30_2083 ENOG4108KF3 Electron transport protein SCO1 SenC GFC30_2084 ENOG4108RCR degv family GFC30_2086 ENOG4105C7B Threonine dehydratase GFC30_2087 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GFC30_2088 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GFC30_2091 ENOG4106E8G GFC30_2092 ENOG4105CHM Aminotransferase GFC30_2094 ENOG4107YX5 Pfam:DUF548 GFC30_2095 ENOG4108Y6J UPF0403 protein GFC30_2099 ENOG4108V06 Glutathione peroxidase GFC30_210 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GFC30_2101 ENOG4105CVG Homoserine O-transsuccinylase GFC30_2103 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GFC30_2106 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GFC30_2107 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GFC30_2108 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GFC30_2109 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GFC30_211 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GFC30_2110 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GFC30_2111 ENOG4108P62 biosynthesis protein (CbiG) GFC30_2112 ENOG4105CIA precorrin-4 C(11)-methyltransferase GFC30_2113 ENOG4105DVK Precorrin-2 c20-methyltransferase GFC30_2114 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase GFC30_2115 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GFC30_2116 ENOG41081F0 Precorrin-8x methylmutase GFC30_2117 ENOG4108JTQ reductase GFC30_2118 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GFC30_2119 ENOG4105E4R Precorrin-3B C17-methyltransferase GFC30_212 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GFC30_2124 ENOG4105DPN Oligoendopeptidase f GFC30_2125 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GFC30_213 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) GFC30_2132 ENOG4105EXQ uroporphyrinogen iii synthase hem4 GFC30_2134 ENOG4108HGU Histidine kinase GFC30_2135 ENOG4105BZU Histidine kinase GFC30_2136 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GFC30_2137 ENOG4105E8R UPF0173 metal-dependent hydrolase GFC30_2139 ENOG4108PJD permease GFC30_214 ENOG4107QJE Chromosome Partitioning Protein GFC30_2140 ENOG4105DM4 PTS System GFC30_2141 ENOG4105DE4 1-phosphofructokinase GFC30_2142 ENOG4105E98 transcriptional regulator DeoR family GFC30_2143 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GFC30_2149 ENOG4105RWS endonuclease I GFC30_215 ENOG4105FA0 parb-like partition protein GFC30_2150 ENOG4105DFD Na H antiporter GFC30_2151 ENOG4107S6Z Na H antiporter GFC30_2152 ENOG4105V75 Transcriptional regulator GFC30_2156 ENOG4108NEV two component transcriptional regulator, LytTR family GFC30_2157 ENOG4108HRK Histidine kinase GFC30_2160 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GFC30_2162 ENOG4105C6Z Gluconate GFC30_2163 ENOG4105CMG Carbohydrate kinase GFC30_2167 ENOG4105CGU Enoyl-CoA hydratase GFC30_217 ENOG4108ZDA Sporulation protein YyaC GFC30_2170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GFC30_2171 ENOG4108NVR Methyl-accepting chemotaxis GFC30_2172 ENOG4108QTI )-transporter GFC30_2176 ENOG4105CKK Glycosyl transferase, family 2 GFC30_2177 ENOG4105EDW glycosyl transferase, family 39 GFC30_2178 ENOG4105KK4 UPF0060 membrane protein GFC30_218 ENOG4105D8X mechanosensitive ion channel GFC30_2182 ENOG4105EAD ABC transporter GFC30_2183 ENOG4105DRP amino acid AbC transporter GFC30_2187 ENOG4105DQ6 Transposase GFC30_219 ENOG4105VDK protein, conserved in bacteria GFC30_2195 ENOG410829K Lysine exporter protein (Lyse ygga) GFC30_2197 ENOG4105D7V transposase GFC30_2199 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GFC30_22 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GFC30_220 ENOG4108J2R molybdopterin oxidoreductase GFC30_2204 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GFC30_2205 ENOG4105C26 Dehydrogenase GFC30_2206 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GFC30_221 ENOG4105C3G gtp-binding protein GFC30_2212 ENOG4105BZ8 glutamate synthase GFC30_2213 ENOG4105BZ8 glutamate synthase GFC30_2214 ENOG4105CBC glutamate synthase GFC30_2215 ENOG4105C5Q Transcriptional regulator GFC30_2216 ENOG4107HP6 Transcriptional regulator GFC30_2217 ENOG4105C6K Malic enzyme GFC30_2218 ENOG4105C82 Malate synthase GFC30_2219 ENOG4105CQB FAD linked oxidase domain protein GFC30_222 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GFC30_2220 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC30_2221 ENOG4105CQB FAD linked oxidase domain protein GFC30_2222 ENOG4105EU0 Major facilitator Superfamily GFC30_2229 ENOG4105CIG ABC transporter GFC30_223 ENOG4108UUM single-stranded DNA-binding protein GFC30_2231 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GFC30_2232 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GFC30_2233 ENOG4105DUM transcriptional regulator, lysR family GFC30_2235 ENOG4107QM2 Aldo Keto reductase GFC30_2236 ENOG4105BZU Histidine kinase GFC30_2237 ENOG4105WH1 Two component transcriptional regulator luxr family GFC30_2238 ENOG4105CJ1 ABC, transporter GFC30_224 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GFC30_2241 ENOG4105D7V transposase GFC30_2242 ENOG41090T1 Membrane GFC30_2244 ENOG41082BM Transcriptional regulator, arsr family GFC30_2246 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GFC30_2247 ENOG4108JU3 Alkyl hydroperoxide reductase GFC30_2248 ENOG4105D3R alkyl hydroperoxide reductase GFC30_2249 ENOG4105CKV Membrane GFC30_225 ENOG4108XMW Membrane GFC30_2250 ENOG410905X membrane-flanked domain protein GFC30_2251 ENOG4105BZ1 (ABC) transporter GFC30_2252 ENOG4105BZ1 (ABC) transporter GFC30_2255 ENOG4108PCN EamA-like transporter family GFC30_2256 ENOG4107V2S Transcriptional regulator GFC30_2257 ENOG4106DF1 GFC30_2258 ENOG4105DWT malate dehydrogenase (quinone) GFC30_226 ENOG4105BZR domain protein GFC30_2261 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GFC30_2263 ENOG4105C26 Dehydrogenase GFC30_2264 ENOG4107YHD transcriptional regulator GFC30_2269 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC30_227 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GFC30_2270 ENOG4108JQ7 (ABC) transporter GFC30_2272 ENOG4105C8Q Methyl-accepting chemotaxis GFC30_228 ENOG4105CDU Replicative dna helicase GFC30_229 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GFC30_2297 ENOG4108IXY short-chain dehydrogenase reductase GFC30_23 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GFC30_230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC30_2301 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GFC30_2302 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GFC30_2303 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GFC30_2306 ENOG4105BZU Histidine kinase GFC30_2308 ENOG4105KVH Transcriptional regulator GFC30_231 ENOG4105BZU Histidine kinase GFC30_2324 ENOG4108QBV Monogalactosyldiacylglycerol synthase GFC30_2327 ENOG4105GR3 Histidine kinase GFC30_2328 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC30_2332 ENOG4105BZU Histidine kinase GFC30_2333 ENOG4105MYT Heat shock protein GFC30_2334 ENOG4105CQ4 Transcriptional regulator GFC30_2336 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase GFC30_2337 ENOG4105CMR udp-glucose 4-epimerase GFC30_2338 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GFC30_2339 ENOG4105EU9 GFC30_234 ENOG4105Q2H domain protein GFC30_2340 ENOG4107SDZ Galactoside transport system permease protein mglC GFC30_2341 ENOG4105C2J ABC transporter GFC30_2342 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator GFC30_2343 ENOG4105D7V transposase GFC30_2345 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GFC30_2346 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GFC30_2348 ENOG4105GR3 Histidine kinase GFC30_2349 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC30_235 ENOG4105C0H protease GFC30_2357 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GFC30_2358 ENOG4105BZ4 penicillin-binding protein GFC30_2360 ENOG4105CSM endonuclease III GFC30_2362 ENOG4105C5S asparaginyl-tRNA synthetase GFC30_2369 ENOG4105YAC GFC30_237 ENOG4108C33 Resolvase GFC30_2370 ENOG4105DVT helicase GFC30_2371 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GFC30_2372 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GFC30_2373 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GFC30_2374 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GFC30_2375 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GFC30_2376 ENOG4105CPK Glycosyl transferase (Group 1 GFC30_2377 ENOG4105FJR Lmbe family GFC30_2378 ENOG4108Z5K methylglyoxal synthase GFC30_2379 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GFC30_238 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GFC30_2380 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GFC30_2381 ENOG4108JYZ YitT family GFC30_2384 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit GFC30_2385 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GFC30_2386 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GFC30_2389 ENOG41068YB TPR repeat-containing protein GFC30_2395 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GFC30_2397 ENOG4105CIH Imidazole acetol-phosphate transaminase GFC30_2398 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GFC30_2399 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GFC30_24 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GFC30_240 ENOG41067QW Transcriptional regulator GFC30_2400 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GFC30_2401 ENOG4105DK0 Indole-3-glycerol phosphate synthase GFC30_2402 ENOG4108I0Q anthranilate phosphoribosyltransferase GFC30_2404 ENOG4105KHN chorismate mutase GFC30_2405 ENOG4105D49 3-dehydroquinate synthase GFC30_2406 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GFC30_2407 ENOG4105BZU Histidine kinase GFC30_2408 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GFC30_2410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GFC30_2412 ENOG4105WP2 Tryptophan RNA-binding attenuator protein GFC30_2413 ENOG4105EUJ GTP cyclohydrolase i GFC30_2415 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GFC30_2418 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GFC30_2419 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GFC30_2422 ENOG4105E1K spore germination protein GFC30_2424 ENOG4108Q5U germination protein, ger(x)c family GFC30_2426 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GFC30_2427 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GFC30_2429 ENOG4105CAT Cytidine monophosphate kinase GFC30_243 ENOG4105D5G Transposase GFC30_2432 ENOG4105MSI germination protein ypeb GFC30_2433 ENOG4105F0V Cell wall hydrolase GFC30_2434 ENOG4107TSN permease GFC30_2435 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) GFC30_2436 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GFC30_2438 ENOG4108S6Z Negative regulator of genetic competence GFC30_2439 ENOG4108XDN Transcriptional regulator GFC30_244 ENOG4105D85 methylase GFC30_2440 ENOG4107RGJ metallophosphoesterase GFC30_2444 ENOG4105WEF catalase GFC30_2447 ENOG4105I7S Abortive infection protein GFC30_2448 ENOG4105C9U ATP-dependent DNA helicase RecQ GFC30_245 ENOG4105F6A helicase GFC30_2452 ENOG4108JQ1 Dehydrogenase GFC30_2453 ENOG4107RVV histidinol phosphate phosphatase, hisj family GFC30_2459 ENOG4108WBT adenosyltransferase GFC30_2462 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GFC30_2464 ENOG4107QZB decarboxylase GFC30_2465 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GFC30_2466 ENOG4105E0A ABC, transporter GFC30_2467 ENOG4105EHG Permease protein GFC30_2468 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GFC30_2470 ENOG4105BZU Histidine kinase GFC30_2471 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC30_2472 ENOG4105CRE cytochrome C GFC30_2473 ENOG4107TWT Cytochrome c biogenesis protein GFC30_2474 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC30_2475 ENOG4105FE9 pseudouridine synthase GFC30_2477 ENOG4108JIC nucleoside recognition domain protein GFC30_2478 ENOG4105DZ1 carboxypeptidase GFC30_2479 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GFC30_248 ENOG4105RHY Pfam:UPF0157 GFC30_2486 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GFC30_2487 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GFC30_2490 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GFC30_2491 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GFC30_2492 ENOG4108R6K riboflavin synthase, subunit alpha GFC30_2493 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GFC30_2494 ENOG4107ZE5 PPIases accelerate the folding of proteins GFC30_2495 ENOG4105PTM secreted protein GFC30_2499 ENOG4105G6R Stage v sporulation protein ae GFC30_25 ENOG4105C5H ABC transporter GFC30_2501 ENOG4105CZ3 stage V sporulation protein ad GFC30_2502 ENOG41090VF Stage v sporulation protein ac GFC30_2505 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC30_2506 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GFC30_2508 ENOG4105DZ1 carboxypeptidase GFC30_2512 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC30_2514 ENOG4105I3K Ferric uptake regulator, Fur family GFC30_2515 ENOG4105MZ9 stage II sporulation protein m GFC30_2517 ENOG4108YZ4 nudix hydrolase GFC30_2518 ENOG4105CPC Aldo Keto reductase GFC30_2522 ENOG4106HZJ GFC30_2525 ENOG4108IXY short-chain dehydrogenase reductase GFC30_2526 ENOG41069FQ Metallo-beta-lactamase superfamily GFC30_2527 ENOG4105II7 pyrroline-5-carboxylate reductase GFC30_2528 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GFC30_2533 ENOG4105D7V transposase GFC30_2534 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GFC30_2535 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GFC30_2536 ENOG4107XCH Cyclase family GFC30_254 ENOG4105E5H Transposase GFC30_2541 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GFC30_2543 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GFC30_2545 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GFC30_2548 ENOG4108V3W Chemotaxis protein, CheW GFC30_2549 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GFC30_2550 ENOG4108HNZ carboxyl transferase GFC30_2551 ENOG4108UYE Lactoylglutathione lyase GFC30_2553 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GFC30_2554 ENOG4108QEG Membrane GFC30_2555 ENOG4105CDA abc transporter atp-binding protein GFC30_2556 ENOG4105E5Q amino acid AbC transporter GFC30_2557 ENOG4108HW3 (ABC) transporter GFC30_2558 ENOG4108Y6J UPF0403 protein GFC30_2559 ENOG4105DJT lAO AO transport system ATPase GFC30_2560 ENOG4105D5P Methylmalonyl-coA mutase GFC30_2564 ENOG4105DYB Isoaspartyl dipeptidase GFC30_2565 ENOG4105C7S Dehydrogenase GFC30_2566 ENOG4105CPP Dehydrogenase, E1 component GFC30_2569 ENOG4105CKM Branched-chain carboxylic acid kinase GFC30_2572 ENOG4108JUB Transcriptional regulator GFC30_2573 ENOG4106CCJ Protein of unknown function (DUF2627) GFC30_2574 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GFC30_2577 ENOG4105S1Z Stage IV sporulation protein B GFC30_2578 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GFC30_2579 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GFC30_2580 ENOG4105DX0 Hemolysin A GFC30_2581 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GFC30_2583 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GFC30_2584 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GFC30_2585 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GFC30_2586 ENOG4105M7K Involved in the transcription termination process (By similarity) GFC30_2587 ENOG4108ZSR alkaline shock protein GFC30_2588 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GFC30_2592 ENOG410644B Stage III sporulation protein af GFC30_2594 ENOG4105KQ4 Stage iii sporulation protein ad GFC30_2595 ENOG4108CQH stage III sporulation protein AC GFC30_2596 ENOG4105KR5 Stage iii sporulation protein GFC30_2597 ENOG4105CD2 stage iii sporulation protein aa GFC30_2599 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GFC30_26 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GFC30_2600 ENOG4105DC7 peptidase M24 GFC30_2601 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GFC30_2603 ENOG4105CBJ Metal-dependent enzyme GFC30_2606 ENOG4105KST dependent repressor GFC30_2613 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GFC30_2614 ENOG4105WZW rhodanese family GFC30_2615 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GFC30_2616 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GFC30_2617 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GFC30_2618 ENOG4105C0D helicase GFC30_2626 ENOG4106855 Competence protein GFC30_263 ENOG4105E5H Transposase GFC30_2632 ENOG4105C5X domain protein GFC30_2637 ENOG4105DKQ ROK family GFC30_2641 ENOG4107ZXI Rhomboid family GFC30_2643 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GFC30_2645 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GFC30_2646 ENOG4105WDJ 50S ribosomal protein L33 GFC30_2650 ENOG4108UTW Plays a role in the regulation of phosphate uptake GFC30_2651 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GFC30_2652 ENOG4107RF6 penicillin-binding protein GFC30_2655 ENOG4105C8Q Methyl-accepting chemotaxis GFC30_2657 ENOG4105E2Z phosphate ABC transporter (Permease GFC30_2658 ENOG4105C8U phosphate abc transporter GFC30_2659 ENOG4105CVA phosphate GFC30_266 ENOG4106M28 alanine racemase domain protein GFC30_2661 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GFC30_2662 ENOG41063Y9 GFC30_2663 ENOG4108U5J '-nucleotidase GFC30_2664 ENOG4105N80 Ferric uptake regulator, Fur family GFC30_2665 ENOG4105FAV ABC, transporter GFC30_2666 ENOG4105FDK ABC transporter GFC30_2667 ENOG4108JYZ YitT family GFC30_2669 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GFC30_2672 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GFC30_2673 ENOG4105EGD dinuclear metal center protein, YbgI family GFC30_2677 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC30_2679 ENOG4107XJU UPF0178 protein GFC30_268 ENOG4105BZW Glycerate kinase GFC30_2680 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GFC30_2682 ENOG4105EKQ RNA-directed DNA polymerase GFC30_2683 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GFC30_2685 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GFC30_2686 ENOG4105KG3 cytidine deaminase GFC30_2687 ENOG4107YR5 Diacylglycerol kinase GFC30_2688 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GFC30_2689 ENOG4105C9A Phoh family GFC30_2691 ENOG41068P3 sporulation protein YqfC GFC30_2692 ENOG4105KTH gatB Yqey GFC30_2693 ENOG4105VCC 30S ribosomal protein S21 GFC30_2694 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GFC30_2696 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GFC30_2697 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GFC30_2698 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GFC30_2699 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GFC30_27 ENOG410801F ribosomal-protein-alanine acetyltransferase GFC30_2700 ENOG4105CFG Acts as a chaperone (By similarity) GFC30_2701 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GFC30_2702 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GFC30_2703 ENOG4105CSA Coproporphyrinogen iii oxidase GFC30_2704 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GFC30_2706 ENOG4108ZRV stage ii sporulation protein p GFC30_2707 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) GFC30_2708 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GFC30_2709 ENOG4105TQK DNA polymerase iii, delta' subunit GFC30_2711 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GFC30_2712 ENOG4108UK2 deaminase GFC30_2713 ENOG4105KQC Competence protein GFC30_2715 ENOG4105DXX methyltransferase GFC30_2717 ENOG4108WF2 Metal Dependent Phosphohydrolase GFC30_2718 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GFC30_2719 ENOG410812S Rna-binding protein GFC30_272 ENOG4108EKI Dehydrogenase GFC30_2720 ENOG4105E2X shikimate dehydrogenase GFC30_2721 ENOG4105CQW ribosome biogenesis GTPase YqeH GFC30_2722 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GFC30_2724 ENOG4105DJ4 phosphatidylserine decarboxylase GFC30_2725 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GFC30_2726 ENOG4105E14 MotA TolQ exbB proton channel GFC30_2727 ENOG4105ER2 Ompa motb domain protein GFC30_2728 ENOG4108REF Sporulation integral membrane protein ytvi GFC30_273 ENOG4105F1A Pyruvate formate-lyase GFC30_2730 ENOG4107T5V SNARE associated Golgi GFC30_2732 ENOG4107Y5K Resolvase GFC30_2733 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC30_274 ENOG4107URF beta-phospho-glucomutase GFC30_277 ENOG4105C32 Amino acid ABC transporter (Permease) GFC30_2771 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC30_2776 ENOG4108JPW Aminotransferase GFC30_2778 ENOG4105E5Q amino acid AbC transporter GFC30_278 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GFC30_2780 ENOG4105CDA abc transporter atp-binding protein GFC30_2781 ENOG4105C26 Dehydrogenase GFC30_2782 ENOG4105C0D helicase GFC30_2789 ENOG4105C28 cystathionine GFC30_279 ENOG4105C0Z ABC transporter GFC30_2791 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GFC30_2792 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GFC30_2795 ENOG4107XRG penicillin-binding protein GFC30_2796 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GFC30_2797 ENOG4105DBI uridine monophosphokinase GFC30_2798 ENOG4105CFP Peptidase U32 GFC30_2799 ENOG4105XYU peptidase (U32 family) GFC30_28 ENOG41072GX Peptidase M22 Glycoprotease GFC30_280 ENOG4108IV0 ABC, transporter GFC30_2800 ENOG4108VQJ O-methyltransferase GFC30_2801 ENOG4105HHA aminodeoxychorismate lyase GFC30_2802 ENOG4105VPH UPF0473 protein GFC30_2803 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GFC30_2804 ENOG4105VBH UPF0297 protein GFC30_2805 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GFC30_2806 ENOG4105C02 permease GFC30_281 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GFC30_2816 ENOG41060CR GFC30_2817 ENOG4105C7H Helicase, RecD TraA family GFC30_2819 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GFC30_282 ENOG4105E2S oxidase) subunit II GFC30_2820 ENOG4105C3J Cysteine desulfurase GFC30_2822 ENOG4105D1H recombination factor protein RarA GFC30_2824 ENOG41067SE Tetr family transcriptional regulator GFC30_2826 ENOG4105CUZ uba thif-type nad fad binding protein GFC30_2827 ENOG4105C9M aspartyl-trna synthetase GFC30_2828 ENOG4105CUT histidyl-tRNA synthetase GFC30_283 ENOG4105BZ9 Cytochrome C oxidase, subunit I GFC30_2830 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC30_2831 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GFC30_2832 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GFC30_2833 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GFC30_2834 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GFC30_2835 ENOG41076HS cation diffusion facilitator family transporter GFC30_2836 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GFC30_2838 ENOG4105CKP Polysaccharide Biosynthesis Protein GFC30_2839 ENOG4105NAP GFC30_284 ENOG4105CCU oxidase (Subunit III) GFC30_2840 ENOG4105VIE preprotein translocase, subunit YajC GFC30_2841 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GFC30_2842 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GFC30_2843 ENOG41061AI Protein of unknown function (DUF2905) GFC30_2844 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GFC30_2845 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GFC30_2848 ENOG4105CDY transcriptional regulatory protein GFC30_285 ENOG41060D1 Quinol oxidase GFC30_2850 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GFC30_2852 ENOG4106678 morphogenetic protein associated with SpoVID GFC30_2853 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GFC30_2854 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GFC30_2855 ENOG4108IYU L-aspartate oxidase GFC30_2859 ENOG4105CQC Prephenate dehydratase GFC30_2860 ENOG41090I5 UPF0735 ACT domain-containing protein GFC30_2861 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GFC30_2863 ENOG4105K46 50S ribosomal protein l27 GFC30_2864 ENOG4105X36 (ribosomal) protein GFC30_2865 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GFC30_2868 ENOG4107QMS site-determining protein GFC30_2869 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GFC30_287 ENOG4105E5Q amino acid AbC transporter GFC30_2870 ENOG4105YHC Rod shape-determining protein MreD GFC30_2871 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GFC30_2872 ENOG4105DFF Rod shape-determining protein mreb GFC30_2873 ENOG4105W5Q DNA repair protein (RadC GFC30_2874 ENOG4108Z03 MAF-like protein GFC30_288 ENOG4106PMH Extracellular solute-binding protein family 3 GFC30_2880 ENOG4106A3R peptidase GFC30_2881 ENOG4106855 Competence protein GFC30_2883 ENOG4105CZX twitching motility protein GFC30_2884 ENOG4107QHF type ii secretion system protein e GFC30_289 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GFC30_2893 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GFC30_2894 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GFC30_2897 ENOG41068KH stage VI sporulation protein D GFC30_2897 ENOG41068KH stage VI sporulation protein D GFC30_29 ENOG4105K8N protein family UPF0079, ATPase GFC30_290 ENOG4105DCF alanine dehydrogenase GFC30_2900 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GFC30_2901 ENOG4105D52 delta-aminolevulinic acid dehydratase GFC30_2903 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GFC30_2905 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GFC30_291 ENOG4108K8K Transcriptional regulator GFC30_2913 ENOG4105EKQ RNA-directed DNA polymerase GFC30_2914 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GFC30_2915 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GFC30_2916 ENOG4108IUQ atp-dependent protease GFC30_2917 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GFC30_2918 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GFC30_2920 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GFC30_2921 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GFC30_2922 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GFC30_2923 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GFC30_2924 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GFC30_2925 ENOG4108ZP8 Acetolactate synthase small subunit GFC30_2926 ENOG4105C7K acetolactate synthase GFC30_2928 ENOG4105CM2 brancheD-chain amino acid aminotransferase GFC30_2929 ENOG4105M59 Phosphodiesterase, mj0936 family GFC30_293 ENOG41079KZ Major Facilitator Superfamily GFC30_2930 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GFC30_2931 ENOG4108FK2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GFC30_2932 ENOG4108XJQ germination protein GFC30_2933 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GFC30_2934 ENOG41067TZ transcriptional regulator, MarR family GFC30_2935 ENOG4105PFC Transcriptional regulator GFC30_2937 ENOG4105E33 succinate dehydrogenase GFC30_2939 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GFC30_2943 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GFC30_2947 ENOG4105CKK Glycosyl transferase, family 2 GFC30_2949 ENOG4105C1B dTDP-glucose 4-6-dehydratase GFC30_295 ENOG4108RJ9 Glycosyl transferase, family 2 GFC30_2951 ENOG4105K63 Thioredoxin GFC30_2952 ENOG4105C10 Electron transfer flavoprotein GFC30_2953 ENOG4105BZJ Electron transfer flavoprotein GFC30_2954 ENOG41060WC Enoyl-CoA hydratase GFC30_2955 ENOG4107Z3H Transcriptional regulator, TetR family GFC30_2956 ENOG4105CEY Amp-dependent synthetase and ligase GFC30_2958 ENOG4105C98 muts2 protein GFC30_296 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GFC30_2960 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GFC30_2961 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GFC30_2962 ENOG4105EYF MMPL domain protein GFC30_297 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GFC30_2974 ENOG4108WUZ (ABC) transporter GFC30_2975 ENOG41066N6 Abortive infection protein GFC30_2976 ENOG4107ZBH radical SAM domain protein GFC30_2979 ENOG4105BZU Histidine kinase GFC30_298 ENOG4105CKD glutathione-regulated potassium-efflux system protein GFC30_2986 ENOG4105CJ1 ABC, transporter GFC30_299 ENOG4105CG3 alpha amylase, catalytic region GFC30_3004 ENOG4105BZU Histidine kinase GFC30_3018 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GFC30_3019 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GFC30_3020 ENOG4108RWN rrna methyltransferase GFC30_3021 ENOG41067MF small acid-soluble spore protein GFC30_3022 ENOG4105CN9 Peptidase m42 family protein GFC30_3024 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GFC30_3025 ENOG4105VJV 50s ribosomal protein L35 GFC30_3027 ENOG4105C22 threonyL-tRNA synthetase GFC30_3028 ENOG4108TDW sporulation protein YtxC GFC30_303 ENOG4108VKI Cell wall hydrolase GFC30_3031 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GFC30_3033 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GFC30_3034 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GFC30_3035 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GFC30_3036 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GFC30_3038 ENOG4105BZU Histidine kinase GFC30_3039 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GFC30_304 ENOG4107JTW chlorite dismutase GFC30_3043 ENOG4105EKQ RNA-directed DNA polymerase GFC30_3046 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GFC30_3047 ENOG4108HMX isocitrate dehydrogenase (NADP) GFC30_3048 ENOG4105BZN citrate synthase GFC30_3049 ENOG4108VMM UPF0756 membrane protein GFC30_305 ENOG4108IJ2 phosphate acetyltransferase GFC30_3050 ENOG4108REF Sporulation integral membrane protein ytvi GFC30_3051 ENOG4105FS0 cytoplasmic membrane protein GFC30_3053 ENOG4105CTQ phosphohexokinase GFC30_3054 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GFC30_3055 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GFC30_3056 ENOG41073TP transcriptional regulator GFC30_3058 ENOG4105C0B DNA polymerase III (alpha subunit) GFC30_3059 ENOG4105VV2 GFC30_3062 ENOG4105SFS phosphoesterase RecJ domain protein GFC30_3066 ENOG4105E8R UPF0173 metal-dependent hydrolase GFC30_3067 ENOG4105DC7 peptidase M24 GFC30_3070 ENOG4107YZX Universal stress protein GFC30_3071 ENOG4105CH7 arginosuccinase GFC30_3072 ENOG4105CDH Citrulline--aspartate ligase GFC30_3074 ENOG4105EPU Molybdenum cofactor synthesis domain protein GFC30_3077 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GFC30_3079 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GFC30_3080 ENOG4105KBJ sporulation protein ytfj GFC30_3082 ENOG4105VK3 rdd domain containing protein GFC30_3083 ENOG4105D07 Signal peptide peptidase, SppA GFC30_3084 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GFC30_3085 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GFC30_3087 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GFC30_3089 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) GFC30_3090 ENOG4108W76 histidinol phosphate phosphatase hisj family GFC30_3092 ENOG4105BZU Histidine kinase GFC30_3093 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GFC30_3097 ENOG4105F1V Acetoin utilization protein GFC30_3098 ENOG4105W87 Cbs domain GFC30_3099 ENOG4105DGU Histone deacetylase GFC30_310 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GFC30_3100 ENOG4105ETE Transcriptional regulator (LacI family GFC30_3101 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GFC30_3102 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GFC30_3106 ENOG4105C88 aminopeptidase GFC30_3107 ENOG4105DFU Cell wall formation (By similarity) GFC30_311 ENOG4108VCI transcription factor, rsfa family GFC30_3110 ENOG4108VDD TRNA binding domain protein GFC30_3111 ENOG4108NKM UPF0354 protein GFC30_3114 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GFC30_3117 ENOG4105C8F Beta-lactamase domain protein GFC30_3118 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GFC30_3120 ENOG4108V15 phosphotransferase enzyme family GFC30_3121 ENOG4108IUM Glycogen debranching enzyme GFC30_3122 ENOG4108IUM Glycogen debranching enzyme GFC30_3126 ENOG4107QSE Dipeptidase GFC30_313 ENOG4105QAT UPF0741 protein GFC30_3130 ENOG4105CBX hi0933 family GFC30_3132 ENOG41085GJ domain protein GFC30_3133 ENOG4105C8T Leucyl-tRNA synthetase GFC30_3136 ENOG4105N5T Radical SAM Protein GFC30_3139 ENOG4105E8V Alpha Beta Hydrolase Fold protein GFC30_314 ENOG4105DCI Phosphohydrolase GFC30_3140 ENOG4108Z0R Transferase GFC30_3142 ENOG4105CAQ asparagine synthetase GFC30_3143 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GFC30_3144 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GFC30_3147 ENOG4105C0H protease GFC30_3148 ENOG4105D2X ABC transporter substrate-binding protein GFC30_3150 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC30_3151 ENOG4105XSJ toxin secretion phage lysis holin GFC30_3155 ENOG410906S phage-like element pbsx protein xkdt GFC30_3156 ENOG41066EA baseplate J family protein GFC30_316 ENOG41069HH 4-oxalocrotonate tautomerase GFC30_317 ENOG4108Z4T Peptidase M50 GFC30_3176 ENOG4105IG6 Phage terminase, large subunit GFC30_318 ENOG4108XFG YwhD family GFC30_319 ENOG4105BZ4 penicillin-binding protein GFC30_320 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GFC30_3207 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GFC30_321 ENOG4105CYW agmatinase GFC30_3211 ENOG4108C33 Resolvase GFC30_3212 ENOG4105D2X ABC transporter substrate-binding protein GFC30_3215 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GFC30_3217 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GFC30_3219 ENOG4105XSJ toxin secretion phage lysis holin GFC30_3221 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GFC30_3222 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GFC30_3223 ENOG4105CKI cobalamin synthesis protein GFC30_3231 ENOG4105CEY Amp-dependent synthetase and ligase GFC30_3232 ENOG4108IPT Naphthoate synthase GFC30_3233 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GFC30_3234 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GFC30_3235 ENOG4105E4F Isochorismate synthase GFC30_3236 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GFC30_324 ENOG4105C75 arginyL-tRNA synthetase GFC30_3240 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GFC30_3268 ENOG4105EMN RNA polymerase sigma factor GFC30_3270 ENOG4105C8B TIGR00159 family GFC30_3271 ENOG4107U5W ybbr family GFC30_3272 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GFC30_3273 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GFC30_3275 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GFC30_3286 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC30_3290 ENOG4107EV6 Inherit from COG: YD repeat protein GFC30_3296 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GFC30_330 ENOG4105DF6 Fe-S oxidoreductase GFC30_3300 ENOG4105ENE Histidine kinase GFC30_3301 ENOG4105WH1 Two component transcriptional regulator luxr family GFC30_3302 ENOG4107TXC Transcriptional regulator GFC30_3305 ENOG4105C0X amino acid GFC30_3310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GFC30_3315 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GFC30_3316 ENOG4108ZJ4 polysaccharide deacetylase GFC30_3317 ENOG4107ZTW SNARE associated Golgi GFC30_3319 ENOG4105CPF Cell wall formation (By similarity) GFC30_332 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC30_3320 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GFC30_3322 ENOG4105C1J atp-dependent rna helicase GFC30_3324 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GFC30_3325 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GFC30_3328 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GFC30_333 ENOG4105C1G acyl-Coa dehydrogenase GFC30_3330 ENOG410906U SprT-like GFC30_334 ENOG4105C1G acyl-Coa dehydrogenase GFC30_336 ENOG4105D5P Methylmalonyl-coA mutase GFC30_338 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GFC30_340 ENOG410812K response regulator receiver protein GFC30_342 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GFC30_343 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GFC30_344 ENOG4105CBT Fructose-1,6-bisphosphatase GFC30_345 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GFC30_346 ENOG41082DI 50s ribosomal protein l31 GFC30_347 ENOG4107104 thymidine kinase GFC30_350 ENOG4105BZU Histidine kinase GFC30_351 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GFC30_352 ENOG4105C26 Dehydrogenase GFC30_354 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GFC30_355 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GFC30_356 ENOG4108ZXQ stage ii sporulation protein r GFC30_357 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GFC30_358 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GFC30_36 ENOG4108NMV polysaccharide deacetylase GFC30_360 ENOG4105C8Q Methyl-accepting chemotaxis GFC30_361 ENOG4108YZG isomerase GFC30_362 ENOG4108UIC UPF0340 protein GFC30_363 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GFC30_364 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GFC30_367 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GFC30_369 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GFC30_370 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GFC30_371 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GFC30_372 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GFC30_373 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GFC30_375 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GFC30_376 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC30_377 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GFC30_378 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC30_379 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GFC30_382 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC30_383 ENOG4105D65 subunit l GFC30_384 ENOG4105C8S subunit m GFC30_385 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC30_386 ENOG4106778 Protein of unknown function (DUF1146) GFC30_388 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GFC30_39 ENOG4105D1F ATP-binding protein GFC30_390 ENOG4105JFG SpoIID LytB domain protein GFC30_391 ENOG4105FRN stage II sporulation protein GFC30_392 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GFC30_393 ENOG4105DFF Rod shape-determining protein mreb GFC30_395 ENOG4105CGA flagellar basal-body rod protein FlgG GFC30_398 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GFC30_400 ENOG4105ETE Transcriptional regulator (LacI family GFC30_401 ENOG4108RVA ribokinase GFC30_402 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GFC30_403 ENOG4105C2J ABC transporter GFC30_404 ENOG4105CNN ABC, transporter GFC30_405 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GFC30_406 ENOG4105CAQ asparagine synthetase GFC30_407 ENOG4105DQ6 Transposase GFC30_409 ENOG4105D7V transposase GFC30_411 ENOG41060AI SEC-C motif GFC30_412 ENOG4106I4J membrane GFC30_413 ENOG4105BZU Histidine kinase GFC30_416 ENOG4107TVC Glycosyl transferase, family 2 GFC30_419 ENOG4105EE0 oxidoreductase GFC30_42 ENOG4108UJD 30S ribosomal protein S9 GFC30_420 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein GFC30_421 ENOG4105EVU fructokinase GFC30_423 ENOG41067SE Tetr family transcriptional regulator GFC30_424 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC30_425 ENOG4105EKQ RNA-directed DNA polymerase GFC30_427 ENOG4105C26 Dehydrogenase GFC30_43 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GFC30_431 ENOG4105CFH Aspartokinase GFC30_435 ENOG4105Z8H single-stranded DNA-binding protein GFC30_436 ENOG4108IMY Transcriptional regulator GFC30_439 ENOG4105C0D helicase GFC30_44 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GFC30_440 ENOG4105KBK Zinc finger, swim domain protein GFC30_441 ENOG4105K4H Nlp p60 protein GFC30_443 ENOG4105C6Y Udp-glucose 6-dehydrogenase GFC30_45 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GFC30_450 ENOG4107QRS glycosyltransferase group 2 family protein GFC30_454 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GFC30_455 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GFC30_457 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GFC30_459 ENOG4105D3Q Sugar transferase GFC30_46 ENOG4108JJB ABC transporter GFC30_47 ENOG4108JJB ABC transporter GFC30_470 ENOG4105K4I Scp-like extracellular GFC30_477 ENOG4106KBF Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) GFC30_478 ENOG4105ESV Glycosyl transferase, family 4 GFC30_48 ENOG4108ZT0 50S ribosomal protein l17 GFC30_482 ENOG4107QQG Dehydrogenase GFC30_485 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GFC30_488 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GFC30_489 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GFC30_49 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC30_491 ENOG4105JFG SpoIID LytB domain protein GFC30_493 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC30_494 ENOG4108KGH TRANSCRIPTIONal GFC30_495 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GFC30_496 ENOG4105BZU Histidine kinase GFC30_498 ENOG4105WH1 Two component transcriptional regulator luxr family GFC30_5 ENOG4105C7N Xanthine uracil vitamin C permease GFC30_50 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GFC30_501 ENOG41081UC Inherit from COG: Competence protein GFC30_504 ENOG4105XVJ Protein of unknown function (DUF327) GFC30_505 ENOG4105RU3 GFC30_508 ENOG4105E1Q flagellar hook-associated protein GFC30_509 ENOG4105DTJ flagellar hook-associated protein GFC30_51 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GFC30_510 ENOG4105MKD GFC30_511 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GFC30_512 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GFC30_514 ENOG4105I03 Flagellin GFC30_515 ENOG4107TVC Glycosyl transferase, family 2 GFC30_52 ENOG41067V7 50S ribosomal protein L36 GFC30_521 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GFC30_522 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GFC30_524 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GFC30_525 ENOG4107TVC Glycosyl transferase, family 2 GFC30_526 ENOG41083S7 flagellar protein FlaG GFC30_527 ENOG4107RT6 flagellar hook-associated GFC30_528 ENOG4105MQ3 flagellar protein FliS GFC30_53 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GFC30_533 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GFC30_538 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GFC30_539 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GFC30_54 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GFC30_542 ENOG4105CAK Cell division ATP-binding protein ftsE GFC30_543 ENOG4105CRP Part of the ABC transporter FtsEX involved in GFC30_546 ENOG4105CN1 protease GFC30_547 ENOG41062GF Polar chromosome segregation protein GFC30_55 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GFC30_550 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GFC30_551 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GFC30_553 ENOG41067S9 phage shock protein C, PspC GFC30_554 ENOG41086DT Membrane protein of unknown function GFC30_555 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GFC30_556 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GFC30_557 ENOG4105HKU nucleoside recognition domain-containing protein GFC30_558 ENOG4107XGZ Hydrolase GFC30_559 ENOG4108S4C acetyltransferase GFC30_56 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GFC30_560 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GFC30_561 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GFC30_562 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GFC30_563 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GFC30_564 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GFC30_565 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GFC30_566 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GFC30_567 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GFC30_569 ENOG4105C3M thioredoxin reductase GFC30_57 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GFC30_570 ENOG4108Z4K mutator MutT protein GFC30_571 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GFC30_572 ENOG4105CHW UPF0052 protein GFC30_573 ENOG4105CIE May be required for sporulation (By similarity) GFC30_574 ENOG4105KRI phosphocarrier protein (HPr GFC30_575 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GFC30_577 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC30_58 ENOG4105VPB 50S ribosomal protein L30 GFC30_581 ENOG4105BZA Phosphoglycerate kinase GFC30_582 ENOG4105CP7 Triose-phosphate isomerase GFC30_583 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GFC30_584 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GFC30_585 ENOG4105XZU Preprotein translocase, subunit SecG GFC30_587 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GFC30_588 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GFC30_59 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GFC30_592 ENOG4105BZU Histidine kinase GFC30_593 ENOG4105CA9 Pyruvate kinase GFC30_595 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GFC30_596 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GFC30_6 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GFC30_60 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GFC30_604 ENOG4105CHU acetyl-coa acetyltransferase GFC30_605 ENOG4105C1G acyl-Coa dehydrogenase GFC30_606 ENOG41080E8 Transcriptional regulator, Spx MgsR family GFC30_607 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GFC30_61 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GFC30_613 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GFC30_614 ENOG4108UMI ABC transporter, permease GFC30_615 ENOG4105D01 (LipO)protein GFC30_617 ENOG4105C3K feS assembly ATPase SufC GFC30_618 ENOG4105JRK feS assembly protein SufD GFC30_62 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GFC30_620 ENOG4108UNV SUF system FeS assembly protein, NifU family GFC30_621 ENOG4105DIW FeS assembly protein SUFB GFC30_622 ENOG4105I3N Conserved Protein GFC30_624 ENOG4107R8B 5'-nucleotidase GFC30_625 ENOG4105KZD Domain of unknown function (DUF1805) GFC30_626 ENOG4108YTE sporulation protein YunB GFC30_627 ENOG4105FAA peptidase M23 GFC30_628 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GFC30_629 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GFC30_63 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GFC30_630 ENOG4105MMD transcriptional regulator GFC30_635 ENOG4105D4U had-superfamily hydrolase, subfamily iia GFC30_636 ENOG4108W5N phosphatidylglycerophosphatase a GFC30_638 ENOG4105C5I Dehydrogenase GFC30_639 ENOG4105D6E homoserine dehydrogenase GFC30_64 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GFC30_640 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GFC30_641 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GFC30_642 ENOG41083MR nifu domain-containing protein GFC30_645 ENOG4105ZKE UPF0349 protein GFC30_647 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GFC30_648 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GFC30_649 ENOG4105K4I Scp-like extracellular GFC30_65 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GFC30_650 ENOG41067VP Protein of unknown function (DUF1049) GFC30_651 ENOG4105CAY ferredoxin--nadp reductase GFC30_652 ENOG4105CEP NADH dehydrogenase GFC30_655 ENOG41069ER domain protein GFC30_656 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GFC30_659 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GFC30_66 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GFC30_660 ENOG4107GRR phosphate transport regulator GFC30_661 ENOG4105CJ3 phosphate transporter GFC30_667 ENOG4108J9M Transporter GFC30_67 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GFC30_671 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GFC30_672 ENOG4105C87 Aminotransferase class I and II GFC30_674 ENOG4108ZB6 transcriptional regulator AsnC family GFC30_675 ENOG4105CHM Aminotransferase GFC30_678 ENOG4105WG9 Conserved Protein GFC30_679 ENOG4107QW4 alcohol dehydrogenase GFC30_68 ENOG41082SA 50s ribosomal protein l29 GFC30_681 ENOG4107PBV potassium channel GFC30_683 ENOG4106GRI small acid-soluble spore protein H GFC30_684 ENOG41060AI SEC-C motif GFC30_685 ENOG4107TCE N-acetyltransferase GFC30_687 ENOG4105KT7 mgtC SapB transporter GFC30_69 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GFC30_694 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GFC30_695 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GFC30_696 ENOG4105C83 adenylosuccinate lyase GFC30_697 ENOG4105C8V SAICAR synthetase GFC30_698 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GFC30_699 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GFC30_70 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GFC30_700 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GFC30_702 ENOG4105CXB phosphoribosylaminoimidazole synthetase GFC30_703 ENOG4108V3E phosphoribosylglycinamide formyltransferase GFC30_704 ENOG4105DC1 bifunctional purine biosynthesis protein purh GFC30_706 ENOG4105C12 Phosphoribosylglycinamide synthetase GFC30_709 ENOG4108R5T secreted protein GFC30_71 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GFC30_710 ENOG4105KGF protein, YerC YecD GFC30_711 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) GFC30_713 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GFC30_715 ENOG4105C26 Dehydrogenase GFC30_719 ENOG4105CPN adenine deaminase GFC30_72 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GFC30_720 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GFC30_721 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GFC30_722 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GFC30_727 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GFC30_73 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GFC30_736 ENOG4105C26 Dehydrogenase GFC30_737 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GFC30_738 ENOG4105F38 ABC transporter, permease GFC30_739 ENOG4105D38 putrescine abc transporter GFC30_74 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GFC30_740 ENOG4107RUE extracellular solute-binding protein family 1 GFC30_743 ENOG4105BZU Histidine kinase GFC30_744 ENOG4105XJC Two component transcriptional regulator (Winged helix family GFC30_746 ENOG4105DZ6 Band 7 protein GFC30_75 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GFC30_752 ENOG4105D8G Major Facilitator superfamily GFC30_755 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GFC30_76 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GFC30_77 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GFC30_771 ENOG4108KXV response regulator GFC30_772 ENOG4105EB3 Histidine kinase GFC30_775 ENOG4105CBD Diacylglycerol kinase GFC30_78 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GFC30_782 ENOG4105BZU Histidine kinase GFC30_783 ENOG4105EKQ RNA-directed DNA polymerase GFC30_789 ENOG4105C0H protease GFC30_79 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GFC30_791 ENOG4105HHM rdd domain containing protein GFC30_792 ENOG4108IQI permease GFC30_795 ENOG4105C8Q Methyl-accepting chemotaxis GFC30_796 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GFC30_80 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GFC30_802 ENOG4105XRQ Xanthine dehydrogenase accessory factor GFC30_806 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) GFC30_807 ENOG4105C84 Histidine ammonia-lyase GFC30_808 ENOG4105CGP Urocanate hydratase GFC30_809 ENOG4105CI2 imidazolone-5-propionate hydrolase GFC30_81 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GFC30_810 ENOG4108903 Formimidoylglutamase GFC30_811 ENOG4108ZCF integral membrane protein GFC30_812 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) GFC30_813 ENOG4107QR9 Iron-sulfur cluster binding protein GFC30_814 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC30_815 ENOG4105JXH GntR family transcriptional regulator GFC30_816 ENOG4105DAA L-lactate GFC30_817 ENOG4105CQB FAD linked oxidase domain protein GFC30_818 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC30_82 ENOG4105XPM ribosomal protein GFC30_820 ENOG4105BZU Histidine kinase GFC30_822 ENOG4108Z73 Siroheme synthase GFC30_823 ENOG4108TN2 lmbE family GFC30_826 ENOG410855V Acylphosphatase GFC30_827 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GFC30_828 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GFC30_83 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC30_830 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GFC30_831 ENOG4107RIQ Sulfate adenylate transferase GFC30_833 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GFC30_834 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GFC30_835 ENOG41068PA UPF0435 protein GFC30_836 ENOG4105KJF protein tyrosine phosphatase GFC30_837 ENOG4107U9T Pfam:Ribonuclease_BN GFC30_84 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC30_840 ENOG4108ISG Major Facilitator GFC30_842 ENOG4105UPD Calcium Proton GFC30_85 ENOG4107Y49 methyltransferase GFC30_855 ENOG41081UC Inherit from COG: Competence protein GFC30_859 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GFC30_86 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GFC30_862 ENOG4105CNG UPF0061 protein GFC30_866 ENOG4105WH1 Two component transcriptional regulator luxr family GFC30_87 ENOG4108VZM 50s ribosomal protein L10 GFC30_871 ENOG4105D7V transposase GFC30_872 ENOG4105ECP epimerase GFC30_873 ENOG410902V Modulates RecA activity (By similarity) GFC30_874 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GFC30_877 ENOG4105XHU Acid-soluble spore protein K GFC30_879 ENOG41067AE Membrane-bound metal-dependent hydrolase GFC30_88 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GFC30_881 ENOG4106BXE GFC30_882 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GFC30_885 ENOG4105EVI UPF0374 protein GFC30_886 ENOG4105C3U ABC transporter GFC30_887 ENOG4108JQ7 (ABC) transporter GFC30_889 ENOG4105DEF Extracellular solute-binding protein, family 5 GFC30_89 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GFC30_890 ENOG4105DEF Extracellular solute-binding protein, family 5 GFC30_891 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC30_892 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GFC30_893 ENOG4107NBY Membrane GFC30_894 ENOG4105CBC glutamate synthase GFC30_895 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GFC30_896 ENOG4108IUW ABC transporter GFC30_9 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GFC30_90 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GFC30_900 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC30_901 ENOG4105G5W regulator Fur family GFC30_902 ENOG4105TUA UPF0295 protein GFC30_91 ENOG410683Z Preprotein translocase SecE subunit GFC30_92 ENOG4105QIV RNA polymerase GFC30_93 ENOG4105M0M Tetracycline resistance protein GFC30_931 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GFC30_933 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GFC30_935 ENOG4105CYN Serine protein kinase GFC30_936 ENOG4106AKX UPF0229 protein GFC30_939 ENOG4108MRH transcriptional regulatory protein GFC30_94 ENOG4105C2N RNA methyltransferase TrmH family group 3 GFC30_940 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GFC30_941 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GFC30_942 ENOG4107QJT sodium dicarboxylate symporter GFC30_945 ENOG4105CS1 NAD(P)H quinone oxidoreductase GFC30_946 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GFC30_949 ENOG4105C37 (CBS) domain GFC30_950 ENOG4108YBP pseudouridine synthase GFC30_954 ENOG41080XP Cbs domain GFC30_956 ENOG4105EKQ RNA-directed DNA polymerase GFC30_957 ENOG4105BZU Histidine kinase GFC30_958 ENOG4105WH1 Two component transcriptional regulator luxr family GFC30_96 ENOG4105C8N cysteinyl-tRNA synthetase GFC30_963 ENOG4107ZTW SNARE associated Golgi GFC30_964 ENOG41069DP small acid-soluble spore protein GFC30_965 ENOG4105ED1 spovr family GFC30_967 ENOG4105D7V transposase GFC30_969 ENOG4105ED1 spovr family GFC30_97 ENOG4105D7W serine acetyltransferase GFC30_971 ENOG4108YZA Nitrogen regulatory protein pii GFC30_976 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GFC30_978 ENOG4105XTG Pfam:DUF156 GFC30_979 ENOG4105VFE sira family GFC30_98 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GFC30_980 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GFC30_982 ENOG4105VFE sira family GFC30_983 ENOG4105VFE sira family GFC30_984 ENOG4107TPS domain protein GFC30_985 ENOG41087NI Sulfite exporter TauE/SafE GFC30_986 ENOG4105NQC Flavodoxin GFC30_988 ENOG4108ZCF integral membrane protein GFC30_99 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GFC30_990 ENOG4105D22 carbon starvation protein GFC30_991 ENOG4105VCD cytoplasmic protein GFC30_993 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GFC30_997 ENOG4108JJB ABC transporter GFC30_998 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GFC30_999 ENOG4108VEU Thiamine monophosphate synthase