locus-tag	class	description
ISX45_00025	COG1335	isochorismatase
ISX45_00030	COG1247	-acetyltransferase
ISX45_00035	COG2318	DinB family
ISX45_00045	COG3708	Transcriptional regulator
ISX45_00045	COG2207	Transcriptional regulator
ISX45_00095	COG1136	(ABC) transporter
ISX45_00100	COG0577	efflux transmembrane transporter activity
ISX45_00100	COG1136	(ABC) transporter
ISX45_00105	COG0745	RESPONSE REGULATOR receiver
ISX45_00110	COG5002	protein histidine kinase activity
ISX45_00120	COG1609	Transcriptional regulator
ISX45_00130	COG3290	protein histidine kinase activity
ISX45_00135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISX45_00140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX45_00145	COG1301	dicarboxylic acid transport
ISX45_00150	COG1741	Belongs to the pirin family
ISX45_00155	COG0655	NAD(P)H dehydrogenase (quinone) activity
ISX45_00170	COG2738	Putative neutral zinc metallopeptidase
ISX45_00175	COG1253	flavin adenine dinucleotide binding
ISX45_00180	COG0564	pseudouridine synthase activity
ISX45_00200	COG0366	Alpha amylase catalytic
ISX45_00205	COG0517	IMP dehydrogenase activity
ISX45_00210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISX45_00215	COG1785	Belongs to the alkaline phosphatase family
ISX45_00220	COG4221	oxidoreductase activity
ISX45_00225	COG4585	Histidine kinase
ISX45_00225	COG2203	Gaf domain
ISX45_00230	COG2197	response regulator
ISX45_00235	COG0431	NADPH-dependent FMN reductase
ISX45_00255	COG0586	Pfam SNARE associated Golgi protein
ISX45_00260	COG2719	SpoVR family
ISX45_00265	COG0346	lactoylglutathione lyase activity
ISX45_00270	COG1309	transcriptional regulator
ISX45_00275	COG1511	domain protein
ISX45_00300	COG0386	Belongs to the glutathione peroxidase family
ISX45_00305	COG1959	2 iron, 2 sulfur cluster binding
ISX45_00310	COG2910	NAD(P)H-binding
ISX45_00315	COG2514	catechol 2,3-dioxygenase activity
ISX45_00330	COG2329	Antibiotic biosynthesis monooxygenase
ISX45_00335	COG0697	spore germination
ISX45_00340	COG0716	FMN binding
ISX45_00350	COG0861	Integral membrane protein TerC family
ISX45_00355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISX45_00360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISX45_00370	COG1966	Carbon starvation protein
ISX45_00375	COG2879	small protein
ISX45_00380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISX45_00390	COG0366	Alpha amylase catalytic
ISX45_00395	COG2318	DinB family
ISX45_00405	COG0393	Putative heavy-metal-binding
ISX45_00410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISX45_00420	COG1122	ATPase activity
ISX45_00425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ISX45_00430	COG0352	thiamine-phosphate diphosphorylase activity
ISX45_00435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX45_00445	COG2022	thiamine diphosphate biosynthetic process
ISX45_00450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISX45_00455	COG1253	flavin adenine dinucleotide binding
ISX45_00460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX45_00465	COG0765	amino acid transport
ISX45_00470	COG1126	abc transporter atp-binding protein
ISX45_00485	COG3842	ATPase activity
ISX45_00490	COG2508	Transcriptional regulator
ISX45_00510	COG0189	ligase activity
ISX45_00515	COG0189	ligase activity
ISX45_00525	COG4399	Belongs to the UPF0754 family
ISX45_00530	COG3679	Belongs to the UPF0342 family
ISX45_00535	COG0561	phosphatase activity
ISX45_00540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISX45_00555	COG4152	abc transporter atp-binding protein
ISX45_00560	COG1668	transmembrane transport
ISX45_00565	COG3481	metal-dependent phosphohydrolase, HD sub domain
ISX45_00575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISX45_00585	COG1846	Transcriptional regulator
ISX45_00605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISX45_00610	COG0537	adenosine 5'-monophosphoramidase activity
ISX45_00615	COG1131	(ABC) transporter
ISX45_00620	COG4473	ABC transporter
ISX45_00625	COG2329	Antibiotic biosynthesis monooxygenase
ISX45_00630	COG3069	C4-dicarboxylate transmembrane transporter activity
ISX45_00635	COG1473	amidohydrolase
ISX45_00640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISX45_00645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISX45_00650	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ISX45_00655	COG1309	transcriptional regulator
ISX45_00660	COG1511	domain protein
ISX45_00665	COG1609	Transcriptional regulator
ISX45_00670	COG1653	transport
ISX45_00690	COG1234	tRNA 3'-trailer cleavage
ISX45_00700	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_00710	COG4120	Belongs to the binding-protein-dependent transport system permease family
ISX45_00715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX45_00730	COG1131	(ABC) transporter
ISX45_00735	COG2197	response regulator
ISX45_00740	COG4585	Histidine kinase
ISX45_00745	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ISX45_00765	COG0501	Belongs to the peptidase M48B family
ISX45_00775	COG2224	Isocitrate lyase
ISX45_00790	COG4903	ComK protein
ISX45_00800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISX45_00840	COG1522	sequence-specific DNA binding
ISX45_00860	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ISX45_00935	COG1802	Transcriptional regulator
ISX45_00935	COG4626	Terminase
ISX45_01010	COG4824	toxin secretion phage lysis holin
ISX45_01070	COG0398	Pfam SNARE associated Golgi protein
ISX45_01080	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ISX45_01085	COG1074	ATP-dependent DNA helicase activity
ISX45_01090	COG0420	3'-5' exonuclease activity
ISX45_01095	COG0419	ATPase involved in DNA repair
ISX45_01140	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_01145	COG2311	Membrane
ISX45_01155	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISX45_01160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISX45_01180	COG0367	asparagine synthase
ISX45_01200	COG2182	Extracellular solute-binding protein
ISX45_01205	COG1175	transmembrane transport
ISX45_01210	COG3833	ABC-type maltose transport systems, permease component
ISX45_01215	COG0366	Alpha amylase catalytic
ISX45_01215	COG1874	Beta-galactosidase
ISX45_01230	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISX45_01235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISX45_01240	COG1733	regulation of RNA biosynthetic process
ISX45_01245	COG3153	acetyltransferase
ISX45_01245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISX45_01250	COG0456	acetyltransferase
ISX45_01260	COG0693	protein deglycase activity
ISX45_01265	COG2801	Transposase and inactivated derivatives
ISX45_01270	COG2801	Transposase and inactivated derivatives
ISX45_01280	COG2814	Major facilitator Superfamily
ISX45_01285	COG1846	Transcriptional regulator
ISX45_01295	COG2124	cytochrome p450
ISX45_01300	COG1846	Transcriptional regulator
ISX45_01310	COG2801	Transposase and inactivated derivatives
ISX45_01325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISX45_01330	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ISX45_01335	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_01340	COG1410	methionine synthase
ISX45_01340	COG0646	methionine synthase
ISX45_01345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISX45_01345	COG0646	methionine synthase
ISX45_01350	COG1666	GTP binding
ISX45_01355	COG2996	Protein conserved in bacteria
ISX45_01360	COG1744	ABC transporter substrate-binding protein PnrA-like
ISX45_01365	COG0840	transmembrane signaling receptor activity
ISX45_01375	COG1307	EDD domain protein, DegV family
ISX45_01380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_01395	COG0561	phosphatase activity
ISX45_01400	COG1073	alpha beta
ISX45_01410	COG0746	molybdenum cofactor guanylyltransferase activity
ISX45_01415	COG4149	molybdate abc transporter
ISX45_01420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISX45_01425	COG0303	'Molybdopterin
ISX45_01435	COG0314	molybdopterin synthase activity
ISX45_01440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISX45_01455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISX45_01460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ISX45_01465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISX45_01485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISX45_01495	COG0542	response to heat
ISX45_01505	COG2267	carboxylic ester hydrolase activity
ISX45_01515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX45_01520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISX45_01525	COG5504	Zn-dependent protease
ISX45_01545	COG4166	transmembrane transport
ISX45_01550	COG0601	transmembrane transport
ISX45_01555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX45_01560	COG0444	Belongs to the ABC transporter superfamily
ISX45_01565	COG4608	Belongs to the ABC transporter superfamily
ISX45_01575	COG1393	Belongs to the ArsC family
ISX45_01580	COG0861	Integral membrane protein TerC family
ISX45_01590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISX45_01600	COG1164	Oligoendopeptidase f
ISX45_01610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISX45_01615	COG2346	COG2346, Truncated hemoglobins
ISX45_01620	COG0741	lytic transglycosylase activity
ISX45_01625	COG4116	CYTH
ISX45_01635	COG2357	RelA SpoT domain protein
ISX45_01645	COG0564	pseudouridine synthase activity
ISX45_01650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISX45_01655	COG0772	Belongs to the SEDS family
ISX45_01660	COG2239	Acts as a magnesium transporter
ISX45_01685	COG0438	transferase activity, transferring glycosyl groups
ISX45_01690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISX45_01695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ISX45_01700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISX45_01755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX45_01770	COG2323	membrane
ISX45_01780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_01805	COG2153	protein acetylation
ISX45_01810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISX45_01815	COG2382	esterase
ISX45_01820	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_01830	COG0626	cystathionine gamma-synthase activity
ISX45_01835	COG0626	cystathionine gamma-synthase activity
ISX45_01840	COG1418	mRNA catabolic process
ISX45_01845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISX45_01905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX45_01910	COG3162	membrane
ISX45_01915	COG0531	amino acid
ISX45_01920	COG1191	sigma factor activity
ISX45_01940	COG1609	Transcriptional regulator
ISX45_01950	COG2814	Major facilitator Superfamily
ISX45_01955	COG1063	alcohol dehydrogenase
ISX45_01985	COG5002	protein histidine kinase activity
ISX45_01990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISX45_02000	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISX45_02005	COG1129	ABC transporter
ISX45_02010	COG1879	ABC-type sugar transport system periplasmic component
ISX45_02015	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISX45_02020	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ISX45_02025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISX45_02030	COG0436	Aminotransferase
ISX45_02035	COG1850	ribulose-bisphosphate carboxylase activity
ISX45_02040	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISX45_02045	COG0235	Class ii aldolase
ISX45_02050	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISX45_02065	COG1846	Transcriptional regulator
ISX45_02070	COG4869	propanediol catabolic process
ISX45_02075	COG0531	amino acid
ISX45_02085	COG1051	belongs to the nudix hydrolase family
ISX45_02095	COG1131	(ABC) transporter
ISX45_02110	COG0542	response to heat
ISX45_02120	COG3949	Membrane
ISX45_02145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISX45_02150	COG0720	synthase
ISX45_02170	COG0702	epimerase
ISX45_02175	COG4873	Protein conserved in bacteria
ISX45_02180	COG3773	Cell wall hydrolase
ISX45_02205	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_02225	COG5002	protein histidine kinase activity
ISX45_02230	COG0778	Nitroreductase
ISX45_02245	COG0475	glutathione-regulated potassium exporter activity
ISX45_02255	COG0596	Alpha beta hydrolase
ISX45_02265	COG0561	phosphatase activity
ISX45_02270	COG3711	transcriptional antiterminator
ISX45_02275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX45_02275	COG2190	(PTS) system
ISX45_02275	COG1263	PTS System
ISX45_02300	COG0840	transmembrane signaling receptor activity
ISX45_02310	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_02315	COG2314	TM2 domain
ISX45_02320	COG2084	Dehydrogenase
ISX45_02330	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_02340	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_02360	COG0436	Aminotransferase
ISX45_02370	COG0598	Magnesium transport protein CorA
ISX45_02380	COG2814	Major facilitator Superfamily
ISX45_02400	COG0835	chemotaxis
ISX45_02400	COG0784	Response regulator, receiver
ISX45_02430	COG1408	metallophosphoesterase
ISX45_02435	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_02440	COG4990	cell redox homeostasis
ISX45_02445	COG2200	EAL domain
ISX45_02470	COG0517	IMP dehydrogenase activity
ISX45_02480	COG0583	DNA-binding transcription factor activity
ISX45_02485	COG2171	N-acyltransferase activity
ISX45_02490	COG1473	amidohydrolase
ISX45_02500	COG0668	transmembrane transport
ISX45_02505	COG0450	alkyl hydroperoxide reductase
ISX45_02510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_02525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ISX45_02530	COG5503	Protein of unknown function (DUF1447)
ISX45_02535	COG0561	phosphatase activity
ISX45_02590	COG1280	lysine exporter protein (LysE YggA)
ISX45_02595	COG1982	Orn Lys Arg decarboxylase major
ISX45_02605	COG4476	Belongs to the UPF0223 family
ISX45_02615	COG0483	inositol monophosphate 1-phosphatase activity
ISX45_02625	COG1217	gtp-binding protein TYPA
ISX45_02640	COG4896	Protein conserved in bacteria
ISX45_02655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISX45_02660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISX45_02665	COG4838	Belongs to the UPF0358 family
ISX45_02670	COG0772	Belongs to the SEDS family
ISX45_02675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ISX45_02680	COG1612	heme a metabolic process
ISX45_02685	COG0109	protoheme IX farnesyltransferase activity
ISX45_02710	COG3336	cytochrome c oxidase
ISX45_02730	COG2340	Cysteine-rich secretory protein family
ISX45_02735	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ISX45_02740	COG2340	Cysteine-rich secretory protein family
ISX45_02760	COG3679	Belongs to the UPF0342 family
ISX45_02765	COG4471	UPF0298 protein
ISX45_02785	COG0742	ribosomal rna small subunit methyltransferase
ISX45_02790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ISX45_02795	COG3314	Sporulation integral membrane protein YlbJ
ISX45_02800	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISX45_02805	COG3480	Lon protease (S16) C-terminal proteolytic domain
ISX45_02810	COG1323	Belongs to the UPF0348 family
ISX45_02815	COG1399	metal-binding, possibly nucleic acid-binding protein
ISX45_02820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISX45_02825	COG1024	Enoyl-CoA hydratase
ISX45_02835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISX45_02845	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ISX45_02850	COG0275	rRNA processing
ISX45_02860	COG0768	penicillin binding
ISX45_02865	COG0768	penicillin binding
ISX45_02870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISX45_02880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISX45_02885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ISX45_02890	COG0772	Belongs to the SEDS family
ISX45_02895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISX45_02900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISX45_02905	COG3879	Bacterial protein of unknown function (DUF881)
ISX45_02910	COG3879	Bacterial protein of unknown function (DUF881)
ISX45_02915	COG3856	small basic protein
ISX45_02920	COG0849	cell division
ISX45_02925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISX45_02935	COG1191	sigma factor activity
ISX45_02940	COG1191	sigma factor activity
ISX45_02945	COG1873	PFAM PRC-barrel domain
ISX45_02955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISX45_02960	COG1799	cell septum assembly
ISX45_02965	COG0762	integral membrane protein
ISX45_02970	COG2302	S4 RNA-binding domain
ISX45_02975	COG3599	regulation of cell shape
ISX45_02980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ISX45_02985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ISX45_02990	COG0564	pseudouridine synthase activity
ISX45_02995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ISX45_03005	COG0540	Belongs to the ATCase OTCase family
ISX45_03010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISX45_03025	COG0543	2 iron, 2 sulfur cluster binding
ISX45_03030	COG0167	dihydroorotate dehydrogenase activity
ISX45_03035	COG0284	orotidine-5'-phosphate decarboxylase activity
ISX45_03050	COG0577	efflux transmembrane transporter activity
ISX45_03050	COG1136	(ABC) transporter
ISX45_03055	COG1136	(ABC) transporter
ISX45_03055	COG0577	efflux transmembrane transporter activity
ISX45_03065	COG5002	protein histidine kinase activity
ISX45_03075	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ISX45_03080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ISX45_03085	COG1561	YicC-like family, N-terminal region
ISX45_03090	COG2052	Domain of unknown function (DUF370)
ISX45_03095	COG0194	GDP metabolic process
ISX45_03100	COG1758	RNA polymerase activity
ISX45_03105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISX45_03110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISX45_03115	COG0242	peptide deformylase activity
ISX45_03120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISX45_03125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISX45_03125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISX45_03130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISX45_03135	COG0631	protein serine/threonine phosphatase activity
ISX45_03140	COG0515	serine threonine protein kinase
ISX45_03140	COG2815	serine threonine protein kinase
ISX45_03145	COG1162	GTPase activity
ISX45_03150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISX45_03155	COG1564	THIamine pyrophosphokinase
ISX45_03165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ISX45_03170	COG1302	Protein conserved in bacteria
ISX45_03175	COG1461	Dihydroxyacetone kinase
ISX45_03180	COG1760	l-serine dehydratase
ISX45_03185	COG1760	l-serine dehydratase
ISX45_03190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISX45_03195	COG1349	DNA-binding transcription factor activity
ISX45_03200	COG0416	fatty acid biosynthetic process
ISX45_03205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISX45_03210	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_03215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISX45_03220	COG0571	ribonuclease III activity
ISX45_03225	COG1196	nuclear chromosome segregation
ISX45_03230	COG0552	protein localization to endoplasmic reticulum
ISX45_03235	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ISX45_03240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISX45_03245	COG0228	four-way junction DNA binding
ISX45_03250	COG1837	Belongs to the UPF0109 family
ISX45_03260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISX45_03265	COG0336	Belongs to the RNA methyltransferase TrmD family
ISX45_03270	COG0335	large ribosomal subunit rRNA binding
ISX45_03280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ISX45_03285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ISX45_03295	COG2257	FlhB HrpN YscU SpaS Family
ISX45_03300	COG0045	succinate-CoA ligase (ADP-forming) activity
ISX45_03305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISX45_03310	COG0758	DNA mediated transformation
ISX45_03315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISX45_03320	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ISX45_03325	COG4974	Belongs to the 'phage' integrase family
ISX45_03330	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ISX45_03335	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISX45_03340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ISX45_03345	COG1815	bacterial-type flagellum-dependent cell motility
ISX45_03350	COG1558	bacterial-type flagellum-dependent cell motility
ISX45_03355	COG1677	Flagellar hook-basal body complex protein FliE
ISX45_03360	COG1766	The M ring may be actively involved in energy transduction
ISX45_03365	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ISX45_03370	COG1317	bacterial-type flagellum organization
ISX45_03375	COG1157	protein secretion by the type III secretion system
ISX45_03380	COG2882	bacterial-type flagellum organization
ISX45_03390	COG3144	bacterial-type flagellum assembly
ISX45_03395	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISX45_03400	COG4786	Flagellar basal body rod
ISX45_03405	COG1582	Flagellar protein (FlbD)
ISX45_03415	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ISX45_03420	COG1776	CheC inhibitor of MCP methylation
ISX45_03420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ISX45_03425	COG2201	protein-glutamate methylesterase activity
ISX45_03430	COG3190	flagellar
ISX45_03435	COG1338	Plays a role in the flagellum-specific transport system
ISX45_03440	COG1987	bacterial-type flagellum assembly
ISX45_03445	COG1684	flagellar biosynthetic protein fliR
ISX45_03450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISX45_03455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISX45_03460	COG1419	protein localization to endoplasmic reticulum
ISX45_03465	COG0455	bacterial-type flagellum organization
ISX45_03470	COG2201	protein-glutamate methylesterase activity
ISX45_03475	COG0643	Histidine kinase
ISX45_03475	COG2198	Histidine kinase
ISX45_03480	COG0835	chemotaxis
ISX45_03485	COG1776	CheC inhibitor of MCP methylation
ISX45_03490	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ISX45_03500	COG1191	sigma factor activity
ISX45_03515	COG0052	Belongs to the universal ribosomal protein uS2 family
ISX45_03520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISX45_03525	COG0528	UMP kinase activity
ISX45_03530	COG0233	cytoplasmic translational termination
ISX45_03535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISX45_03540	COG4589	Belongs to the CDS family
ISX45_03545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISX45_03550	COG0750	zinc metalloprotease
ISX45_03555	COG0442	prolyl-tRNA aminoacylation
ISX45_03560	COG2176	DNA-directed DNA polymerase activity
ISX45_03565	COG0779	Required for maturation of 30S ribosomal subunits
ISX45_03570	COG0195	Participates in both transcription termination and antitermination
ISX45_03575	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ISX45_03580	COG1358	cellular component organization or biogenesis
ISX45_03585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ISX45_03590	COG1550	Protein conserved in bacteria
ISX45_03595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ISX45_03600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ISX45_03605	COG0196	riboflavin kinase activity
ISX45_03610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ISX45_03615	COG1185	polyribonucleotide nucleotidyltransferase activity
ISX45_03620	COG0726	polysaccharide deacetylase
ISX45_03625	COG0612	Peptidase, M16
ISX45_03630	COG1873	PFAM PRC-barrel domain
ISX45_03635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISX45_03640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISX45_03645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISX45_03650	COG0527	aspartate kinase activity
ISX45_03660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ISX45_03665	COG0740	serine-type endopeptidase activity
ISX45_03675	COG1674	ftsk spoiiie
ISX45_03675	COG4980	gas vesicle protein
ISX45_03680	COG2188	Transcriptional regulator
ISX45_03685	COG1744	ABC transporter substrate-binding protein PnrA-like
ISX45_03690	COG3845	ABC transporter
ISX45_03695	COG4603	Belongs to the binding-protein-dependent transport system permease family
ISX45_03700	COG1079	Belongs to the binding-protein-dependent transport system permease family
ISX45_03705	COG0612	Peptidase, M16
ISX45_03710	COG0612	Peptidase, M16
ISX45_03715	COG0300	oxidoreductase activity
ISX45_03730	COG1426	Protein conserved in bacteria
ISX45_03735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISX45_03740	COG1058	Belongs to the CinA family
ISX45_03740	COG1546	Belongs to the CinA family
ISX45_03755	COG1418	mRNA catabolic process
ISX45_03760	COG1692	metallophosphoesterase
ISX45_03765	COG2359	stage V sporulation protein S
ISX45_03775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISX45_03775	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISX45_03780	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISX45_03785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISX45_03790	COG4550	Control of competence regulator ComK, YlbF/YmcA
ISX45_03800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISX45_03805	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISX45_03810	COG2855	membrane
ISX45_03820	COG1280	lysine exporter protein (LysE YggA)
ISX45_03840	COG1404	Belongs to the peptidase S8 family
ISX45_03855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_03885	COG0789	Transcriptional regulator
ISX45_03890	COG1664	Polymer-forming cytoskeletal
ISX45_03895	COG1664	Polymer-forming cytoskeletal
ISX45_03900	COG2814	Major facilitator Superfamily
ISX45_03905	COG0477	Major facilitator Superfamily
ISX45_03915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISX45_03920	COG1923	regulation of RNA biosynthetic process
ISX45_03925	COG0464	growth
ISX45_03935	COG1960	acyl-CoA dehydrogenase activity
ISX45_03940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ISX45_03970	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_03975	COG0183	Belongs to the thiolase family
ISX45_03980	COG2860	membrane
ISX45_03985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISX45_03990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ISX45_03995	COG0789	Transcriptional regulator
ISX45_04000	COG0174	glutamine synthetase
ISX45_04005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISX45_04010	COG1388	LysM domain
ISX45_04015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ISX45_04020	COG4224	UPF0291 protein
ISX45_04035	COG3763	UPF0154 protein
ISX45_04040	COG1132	(ABC) transporter
ISX45_04045	COG1132	(ABC) transporter
ISX45_04055	COG0785	Cytochrome C biogenesis protein
ISX45_04060	COG2201	protein-glutamate methylesterase activity
ISX45_04065	COG4846	Membrane protein involved in cytochrome C biogenesis
ISX45_04075	COG3773	Cell wall hydrolase
ISX45_04080	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISX45_04080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISX45_04100	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISX45_04105	COG1486	melibiose metabolic process
ISX45_04130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISX45_04155	COG0328	RNA-DNA hybrid ribonuclease activity
ISX45_04165	COG0328	RNA-DNA hybrid ribonuclease activity
ISX45_04195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISX45_04200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISX45_04205	COG3300	MHYT domain
ISX45_04205	COG5001	Diguanylate cyclase
ISX45_04215	COG4608	Belongs to the ABC transporter superfamily
ISX45_04220	COG0601	transmembrane transport
ISX45_04230	COG0747	negative chemotaxis
ISX45_04240	COG0346	lactoylglutathione lyase activity
ISX45_04245	COG3180	Ammonia monooxygenase
ISX45_04300	COG3711	transcriptional antiterminator
ISX45_04310	COG3037	sugar-specific permease SgaT UlaA
ISX45_04315	COG0582	viral genome integration into host DNA
ISX45_04335	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISX45_04380	COG1114	Component of the transport system for branched-chain amino acids
ISX45_04395	COG3335	DDE superfamily endonuclease
ISX45_04400	COG1136	(ABC) transporter
ISX45_04405	COG0577	efflux transmembrane transporter activity
ISX45_04475	COG0531	amino acid
ISX45_04485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX45_04495	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ISX45_04500	COG0367	asparagine synthase
ISX45_04520	COG1113	amino acid transport
ISX45_04525	COG1349	DNA-binding transcription factor activity
ISX45_04530	COG3395	kinase activity
ISX45_04535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISX45_04545	COG1376	ErfK ybiS ycfS ynhG family protein
ISX45_04555	COG2819	hydrolase of the alpha beta superfamily
ISX45_04560	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_04565	COG1169	isochorismate synthase
ISX45_04570	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISX45_04575	COG1535	isochorismatase
ISX45_04575	COG3433	isochorismatase activity
ISX45_04580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISX45_04585	COG3251	PFAM MbtH domain protein
ISX45_04600	COG1388	LysM domain
ISX45_04600	COG0791	NLP P60 protein
ISX45_04620	COG3414	Phosphotransferase system galactitol-specific IIB component
ISX45_04625	COG3775	system Galactitol-specific IIC component
ISX45_04630	COG1063	alcohol dehydrogenase
ISX45_04640	COG1063	alcohol dehydrogenase
ISX45_04645	COG0583	DNA-binding transcription factor activity
ISX45_04650	COG0070	glutamate synthase
ISX45_04650	COG0067	glutamate synthase
ISX45_04650	COG0069	glutamate synthase activity
ISX45_04655	COG0493	'glutamate synthase
ISX45_04670	COG1126	abc transporter atp-binding protein
ISX45_04675	COG0765	amino acid transport
ISX45_04680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX45_04685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISX45_04695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISX45_04700	COG3858	chitin binding
ISX45_04700	COG1388	LysM domain
ISX45_04730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX45_04735	COG4521	taurine ABC transporter
ISX45_04745	COG2175	clavaminate synthase activity
ISX45_04750	COG2076	Multidrug Resistance protein
ISX45_04755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_04765	COG3290	protein histidine kinase activity
ISX45_04765	COG3829	transcription factor binding
ISX45_04770	COG2376	Dihydroxyacetone kinase
ISX45_04780	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ISX45_04785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_04790	COG3284	Transcriptional regulator
ISX45_04795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISX45_04800	COG0022	dehydrogenase e1 component
ISX45_04805	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISX45_04850	COG2508	Transcriptional regulator
ISX45_04855	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_04860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISX45_04885	COG2116	formate transmembrane transporter activity
ISX45_04895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISX45_04900	COG0693	protein deglycase activity
ISX45_04915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX45_04925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISX45_04930	COG0438	transferase activity, transferring glycosyl groups
ISX45_04965	COG1657	PFAM Prenyltransferase squalene oxidase
ISX45_04975	COG1737	Transcriptional regulator
ISX45_04980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_04980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_04980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_04985	COG0383	alpha-mannosidase activity
ISX45_05000	COG1737	Transcriptional regulator
ISX45_05005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ISX45_05010	COG1263	PTS System
ISX45_05010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX45_05020	COG0667	Aldo Keto reductase
ISX45_05030	COG3711	transcriptional antiterminator
ISX45_05060	COG3290	protein histidine kinase activity
ISX45_05065	COG4565	transcriptional regulatory protein
ISX45_05075	COG0840	transmembrane signaling receptor activity
ISX45_05080	COG1609	Transcriptional regulator
ISX45_05085	COG1070	Carbohydrate kinase
ISX45_05095	COG0456	acetyltransferase
ISX45_05100	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISX45_05115	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_05130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISX45_05135	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_05140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISX45_05150	COG1024	Enoyl-CoA hydratase
ISX45_05155	COG0402	S-adenosylhomocysteine deaminase activity
ISX45_05160	COG1522	sequence-specific DNA binding
ISX45_05165	COG2362	D-Aminopeptidase
ISX45_05170	COG0601	transmembrane transport
ISX45_05175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX45_05180	COG0444	Belongs to the ABC transporter superfamily
ISX45_05185	COG4608	Belongs to the ABC transporter superfamily
ISX45_05190	COG4166	transmembrane transport
ISX45_05200	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ISX45_05215	COG2070	2-Nitropropane dioxygenase
ISX45_05220	COG4213	ABC transporter substrate-binding protein
ISX45_05230	COG4214	carbohydrate transport
ISX45_05245	COG1069	ribulokinase activity
ISX45_05250	COG2160	L-arabinose isomerase activity
ISX45_05285	COG4213	ABC transporter substrate-binding protein
ISX45_05290	COG1129	ABC transporter
ISX45_05295	COG4214	carbohydrate transport
ISX45_05310	COG1070	Carbohydrate kinase
ISX45_05315	COG0628	permease
ISX45_05320	COG3290	protein histidine kinase activity
ISX45_05320	COG3829	transcription factor binding
ISX45_05335	COG1454	alcohol dehydrogenase
ISX45_05355	COG0789	Transcriptional regulator
ISX45_05360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISX45_05365	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISX45_05370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISX45_05375	COG2723	6-phospho-beta-galactosidase activity
ISX45_05380	COG2188	Transcriptional regulator
ISX45_05390	COG0726	polysaccharide deacetylase
ISX45_05395	COG1408	metallophosphoesterase
ISX45_05400	COG1757	Na H antiporter
ISX45_05450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISX45_05450	COG2199	diguanylate cyclase activity
ISX45_05455	COG0456	acetyltransferase
ISX45_05460	COG1349	DNA-binding transcription factor activity
ISX45_05465	COG1105	Belongs to the carbohydrate kinase PfkB family
ISX45_05470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_05470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_05470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_05475	COG0701	Predicted permease
ISX45_05480	COG3689	TIGRFAM TIGR03943 family protein
ISX45_05485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISX45_05490	COG0432	Pfam Uncharacterised protein family UPF0047
ISX45_05510	COG5002	protein histidine kinase activity
ISX45_05520	COG1587	Uroporphyrinogen-III synthase
ISX45_05535	COG0706	membrane insertase activity
ISX45_05540	COG1164	Oligoendopeptidase f
ISX45_05545	COG4989	oxidoreductase activity
ISX45_05550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISX45_05575	COG0456	acetyltransferase
ISX45_05600	COG0310	cobalt ion transport
ISX45_05605	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
ISX45_05615	COG1122	ATPase activity
ISX45_05640	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ISX45_05670	COG1492	cobalamin metabolic process
ISX45_05675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ISX45_05685	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ISX45_05690	COG2226	methyltransferase
ISX45_05700	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISX45_05715	COG0386	Belongs to the glutathione peroxidase family
ISX45_05720	COG1418	mRNA catabolic process
ISX45_05725	COG0488	(ABC) transporter
ISX45_05730	COG1413	lyase activity
ISX45_05740	COG2521	methyltransferase
ISX45_05740	COG2136	Putative SAM-dependent methyltransferase
ISX45_05750	COG0436	Aminotransferase
ISX45_05760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ISX45_05765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISX45_05775	COG1272	protein, Hemolysin III
ISX45_05785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISX45_05795	COG1307	EDD domain protein, DegV family
ISX45_05800	COG1999	signal sequence binding
ISX45_05805	COG2755	lipolytic protein G-D-S-L family
ISX45_05815	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ISX45_05815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISX45_05820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ISX45_05825	COG0277	FAD linked oxidase domain protein
ISX45_05830	COG0247	lactate metabolic process
ISX45_05835	COG0277	FAD linked oxidase domain protein
ISX45_05840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISX45_05845	COG0281	malic enzyme
ISX45_05850	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISX45_05855	COG1414	Transcriptional regulator
ISX45_05860	COG1765	OsmC-like protein
ISX45_05875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_05880	COG1525	nuclease
ISX45_05880	COG4085	toxin activity
ISX45_05880	COG0737	Belongs to the 5'-nucleotidase family
ISX45_05885	COG1271	oxidase subunit
ISX45_05890	COG1294	oxidase, subunit
ISX45_05895	COG4988	ABC transporter
ISX45_05900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISX45_05910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX45_05930	COG3647	Membrane
ISX45_05935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISX45_06005	COG0456	acetyltransferase
ISX45_06010	COG0384	phenazine biosynthesis protein PhzF
ISX45_06045	COG1331	Highly conserved protein containing a thioredoxin domain
ISX45_06050	COG1331	Highly conserved protein containing a thioredoxin domain
ISX45_06055	COG1832	CoA-binding protein
ISX45_06060	COG0187	DNA topoisomerase II activity
ISX45_06065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISX45_06080	COG1263	PTS System
ISX45_06080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX45_06085	COG0366	Alpha amylase catalytic
ISX45_06090	COG2188	Transcriptional regulator
ISX45_06095	COG1757	Na H antiporter
ISX45_06100	COG0824	Thioesterase
ISX45_06110	COG1960	acyl-CoA dehydrogenase activity
ISX45_06115	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ISX45_06120	COG1959	2 iron, 2 sulfur cluster binding
ISX45_06125	COG1017	nitric oxide dioxygenase activity
ISX45_06125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISX45_06130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISX45_06130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISX45_06135	COG0788	formyltetrahydrofolate deformylase activity
ISX45_06145	COG0714	Associated with various cellular activities
ISX45_06150	COG4548	von Willebrand factor, type A
ISX45_06155	COG2404	hydrolase activity, acting on ester bonds
ISX45_06175	COG1309	transcriptional regulator
ISX45_06180	COG0109	protoheme IX farnesyltransferase activity
ISX45_06250	COG1611	Belongs to the LOG family
ISX45_06255	COG0167	dihydroorotate dehydrogenase activity
ISX45_06260	COG3238	Protein conserved in bacteria
ISX45_06280	COG1051	belongs to the nudix hydrolase family
ISX45_06285	COG2368	4-hydroxyphenylacetate
ISX45_06295	COG2226	methyltransferase
ISX45_06305	COG2211	Major facilitator Superfamily
ISX45_06325	COG3340	Belongs to the peptidase S51 family
ISX45_06340	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_06345	COG0583	DNA-binding transcription factor activity
ISX45_06365	COG5634	Uncharacterized conserved protein (DUF2278)
ISX45_06390	COG1132	(ABC) transporter
ISX45_06395	COG1132	(ABC) transporter
ISX45_06460	COG0604	alcohol dehydrogenase
ISX45_06470	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISX45_06475	COG0567	Dehydrogenase, E1 component
ISX45_06490	COG0531	amino acid
ISX45_06495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISX45_06500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISX45_06505	COG0640	Transcriptional regulator
ISX45_06520	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_06525	COG1309	transcriptional regulator
ISX45_06530	COG0183	Belongs to the thiolase family
ISX45_06540	COG2030	dehydratase
ISX45_06550	COG1960	acyl-CoA dehydrogenase activity
ISX45_06555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISX45_06565	COG0840	transmembrane signaling receptor activity
ISX45_06585	COG0531	amino acid
ISX45_06595	COG0531	amino acid
ISX45_06600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISX45_06625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISX45_06630	COG0640	Transcriptional regulator
ISX45_06635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX45_06635	COG1522	sequence-specific DNA binding
ISX45_06640	COG2313	pseudouridylate synthase activity
ISX45_06650	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISX45_06665	COG0778	Nitroreductase
ISX45_06675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ISX45_06695	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ISX45_06700	COG1131	(ABC) transporter
ISX45_06720	COG4682	membrane
ISX45_06725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX45_06730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISX45_06735	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ISX45_06740	COG1609	Transcriptional regulator
ISX45_06755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX45_06770	COG0730	response to heat
ISX45_06780	COG0390	transport system, permease component
ISX45_06795	COG1278	Cold shock
ISX45_06810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_06815	COG2258	MOSC domain
ISX45_06820	COG1132	(ABC) transporter
ISX45_06825	COG1132	(ABC) transporter
ISX45_06830	COG1366	Belongs to the anti-sigma-factor antagonist family
ISX45_06840	COG2208	phosphoserine phosphatase activity
ISX45_06845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISX45_06855	COG0697	spore germination
ISX45_06880	COG1131	(ABC) transporter
ISX45_06885	COG1725	Transcriptional regulator
ISX45_06890	COG2205	protein histidine kinase activity
ISX45_06895	COG2323	membrane
ISX45_06900	COG0697	spore germination
ISX45_06905	COG0697	spore germination
ISX45_06925	COG2223	nitrite transmembrane transporter activity
ISX45_06945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX45_06950	COG2814	Major facilitator Superfamily
ISX45_06955	COG1566	PFAM secretion protein HlyD family protein
ISX45_06970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISX45_06975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISX45_06980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISX45_06985	COG1024	Enoyl-CoA hydratase
ISX45_06990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISX45_06995	COG0511	ligase activity, forming carbon-carbon bonds
ISX45_07000	COG0439	Biotin carboxylase
ISX45_07005	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_07010	COG1960	acyl-CoA dehydrogenase activity
ISX45_07015	COG1309	transcriptional regulator
ISX45_07020	COG0655	NAD(P)H dehydrogenase (quinone) activity
ISX45_07055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISX45_07060	COG2211	Major facilitator Superfamily
ISX45_07070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ISX45_07075	COG0084	hydrolase, TatD family'
ISX45_07080	COG3852	Histidine kinase
ISX45_07085	COG0534	Mate efflux family protein
ISX45_07115	COG3655	Transcriptional regulator
ISX45_07120	COG3739	integral membrane protein
ISX45_07130	COG2962	Rard protein
ISX45_07145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_07150	COG0450	alkyl hydroperoxide reductase
ISX45_07155	COG0598	Magnesium transport protein CorA
ISX45_07160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISX45_07165	COG2226	methyltransferase
ISX45_07175	COG1876	peptidase activity
ISX45_07180	COG0813	purine-nucleoside phosphorylase activity
ISX45_07210	COG4326	sporulation control protein
ISX45_07215	COG1357	PFAM Pentapeptide repeats (8 copies)
ISX45_07215	COG0515	serine threonine protein kinase
ISX45_07245	COG4479	Belongs to the UPF0346 family
ISX45_07255	COG1509	lysine 2,3-aminomutase activity
ISX45_07260	COG0456	acetyltransferase
ISX45_07265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISX45_07270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISX45_07275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISX45_07280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISX45_07285	COG0492	ferredoxin-NADP+ reductase activity
ISX45_07290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISX45_07315	COG4841	protein insertion into membrane
ISX45_07320	COG2050	protein possibly involved in aromatic compounds catabolism
ISX45_07330	COG0824	Thioesterase
ISX45_07350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_07375	COG3541	Predicted nucleotidyltransferase
ISX45_07380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ISX45_07385	COG1755	Isoprenylcysteine carboxyl methyltransferase
ISX45_07390	COG3424	synthase
ISX45_07395	COG2233	PERMEase
ISX45_07400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISX45_07410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISX45_07415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISX45_07420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISX45_07425	COG1199	ATP-dependent helicase activity
ISX45_07435	COG0116	Belongs to the methyltransferase superfamily
ISX45_07445	COG3599	regulation of cell shape
ISX45_07450	COG4474	Belongs to the UPF0398 family
ISX45_07460	COG3359	exonuclease
ISX45_07465	COG1111	helicase
ISX45_07465	COG1205	dead DEAH box helicase
ISX45_07470	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_07480	COG1131	(ABC) transporter
ISX45_07490	COG0670	Belongs to the BI1 family
ISX45_07495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISX45_07505	COG5002	protein histidine kinase activity
ISX45_07510	COG0745	RESPONSE REGULATOR receiver
ISX45_07520	COG3852	Histidine kinase
ISX45_07550	COG3104	oligopeptide transport
ISX45_07560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_07565	COG0833	amino acid
ISX45_07570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISX45_07585	COG3594	Acyltransferase
ISX45_07590	COG0352	thiamine-phosphate diphosphorylase activity
ISX45_07595	COG0351	phosphomethylpyrimidine kinase
ISX45_07600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ISX45_07605	COG0463	Glycosyl transferase, family 2
ISX45_07615	COG2226	methyltransferase
ISX45_07630	COG3383	formate dehydrogenase (NAD+) activity
ISX45_07645	COG3832	glyoxalase III activity
ISX45_07650	COG0640	Transcriptional regulator
ISX45_07660	COG1914	H( )-stimulated, divalent metal cation uptake system
ISX45_07665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ISX45_07670	COG1984	allophanate hydrolase subunit 2
ISX45_07675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISX45_07680	COG1414	Transcriptional regulator
ISX45_07690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX45_07695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISX45_07695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISX45_07700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX45_07705	COG2011	ABC-type metal ion transport system permease component
ISX45_07710	COG1464	Belongs to the NlpA lipoprotein family
ISX45_07715	COG0371	Dehydrogenase
ISX45_07720	COG0133	tryptophan synthase activity
ISX45_07725	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISX45_07725	COG0456	acetyltransferase
ISX45_07755	COG0534	Mate efflux family protein
ISX45_07765	COG0444	Belongs to the ABC transporter superfamily
ISX45_07770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX45_07775	COG0601	transmembrane transport
ISX45_07780	COG0747	negative chemotaxis
ISX45_07785	COG3011	Protein conserved in bacteria
ISX45_07790	COG2135	peptidase activity
ISX45_07805	COG0475	glutathione-regulated potassium exporter activity
ISX45_07805	COG0569	domain protein
ISX45_07820	COG1960	acyl-CoA dehydrogenase activity
ISX45_07825	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_07845	COG4555	ABC transporter
ISX45_07850	COG1120	ATPase activity
ISX45_07860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_07865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_07870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_07875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_07880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISX45_07900	COG1918	ferrous iron import across plasma membrane
ISX45_07900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ISX45_07905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ISX45_07910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ISX45_07920	COG1619	proteins homologs of microcin C7 resistance protein MccF
ISX45_07935	COG2002	toxin-antitoxin pair type II binding
ISX45_07960	COG3279	Response regulator of the LytR AlgR family
ISX45_07970	COG1847	R3H domain protein
ISX45_07995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISX45_08010	COG4221	oxidoreductase activity
ISX45_08025	COG5002	protein histidine kinase activity
ISX45_08025	COG2198	Histidine kinase
ISX45_08025	COG0784	Response regulator, receiver
ISX45_08060	COG2608	mercury ion transmembrane transporter activity
ISX45_08065	COG2217	Heavy metal translocating P-type atpase
ISX45_08070	COG1937	Protein conserved in bacteria
ISX45_08085	COG1120	ATPase activity
ISX45_08090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_08095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_08100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_08110	COG2176	DNA-directed DNA polymerase activity
ISX45_08120	COG0004	ammonium transporteR
ISX45_08125	COG0745	RESPONSE REGULATOR receiver
ISX45_08130	COG5002	protein histidine kinase activity
ISX45_08135	COG2132	Multicopper oxidase
ISX45_08160	COG3853	Toxic anion resistance protein (TelA)
ISX45_08205	COG0022	dehydrogenase e1 component
ISX45_08235	COG4120	Belongs to the binding-protein-dependent transport system permease family
ISX45_08255	COG3327	negative regulation of DNA-templated transcription, initiation
ISX45_08260	COG1024	Enoyl-CoA hydratase
ISX45_08265	COG0183	Belongs to the thiolase family
ISX45_08270	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_08275	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_08280	COG1024	Enoyl-CoA hydratase
ISX45_08285	COG1024	Enoyl-CoA hydratase
ISX45_08295	COG2151	metal-sulfur cluster biosynthetic enzyme
ISX45_08310	COG3396	Phenylacetate-CoA oxygenase
ISX45_08315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ISX45_08325	COG0626	cystathionine gamma-synthase activity
ISX45_08330	COG0129	dihydroxy-acid dehydratase activity
ISX45_08335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ISX45_08340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISX45_08350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISX45_08355	COG2246	polysaccharide biosynthetic process
ISX45_08360	COG0463	Glycosyl transferase, family 2
ISX45_08365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISX45_08375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISX45_08385	COG5646	InterPro IPR014922
ISX45_08390	COG5646	InterPro IPR014922
ISX45_08395	COG3335	DDE superfamily endonuclease
ISX45_08405	COG0561	phosphatase activity
ISX45_08420	COG1960	acyl-CoA dehydrogenase activity
ISX45_08425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_08430	COG1464	Belongs to the NlpA lipoprotein family
ISX45_08435	COG2011	ABC-type metal ion transport system permease component
ISX45_08440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX45_08445	COG1464	Belongs to the NlpA lipoprotein family
ISX45_08450	COG1473	amidohydrolase
ISX45_08460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISX45_08475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_08480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_08485	COG0583	DNA-binding transcription factor activity
ISX45_08510	COG2066	Belongs to the glutaminase family
ISX45_08515	COG0156	8-amino-7-oxononanoate synthase activity
ISX45_08525	COG4377	Putative membrane peptidase family (DUF2324)
ISX45_08530	COG0346	lactoylglutathione lyase activity
ISX45_08535	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_08555	COG1733	regulation of RNA biosynthetic process
ISX45_08560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISX45_08580	COG0671	phosphoesterase, PA-phosphatase related
ISX45_08585	COG2733	membrane
ISX45_08605	COG0477	Major facilitator Superfamily
ISX45_08605	COG2814	Major facilitator Superfamily
ISX45_08695	COG0071	Belongs to the small heat shock protein (HSP20) family
ISX45_08700	COG1609	Transcriptional regulator
ISX45_08705	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ISX45_08710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISX45_08715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ISX45_08720	COG2217	Heavy metal translocating P-type atpase
ISX45_08730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISX45_08735	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ISX45_08740	COG5002	protein histidine kinase activity
ISX45_08750	COG0071	Belongs to the small heat shock protein (HSP20) family
ISX45_08780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ISX45_08795	COG3331	DNA recombination
ISX45_08800	COG4499	WXG100 protein secretion system (Wss), protein YukC
ISX45_08800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX45_08810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISX45_08815	COG3935	DnaD domain protein
ISX45_08820	COG0017	Asparaginyl-tRNA synthetase
ISX45_08845	COG1199	ATP-dependent helicase activity
ISX45_08845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISX45_08850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ISX45_08855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ISX45_08860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISX45_08870	COG0617	tRNA 3'-terminal CCA addition
ISX45_08875	COG0438	transferase activity, transferring glycosyl groups
ISX45_08880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISX45_08885	COG1803	Methylglyoxal synthase
ISX45_08890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ISX45_08895	COG1694	Mazg nucleotide pyrophosphohydrolase
ISX45_08900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_08910	COG4347	Protein of unknown function (DUF1405)
ISX45_08920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISX45_08940	COG0457	Tetratricopeptide repeat
ISX45_08950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ISX45_08955	COG0287	Prephenate dehydrogenase
ISX45_08960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISX45_08965	COG0159	tryptophan synthase activity
ISX45_08970	COG0133	tryptophan synthase activity
ISX45_08975	COG0135	phosphoribosylanthranilate isomerase activity
ISX45_08980	COG0134	indole-3-glycerol-phosphate synthase activity
ISX45_08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISX45_08995	COG4401	Chorismate mutase type I
ISX45_09000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ISX45_09005	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ISX45_09010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISX45_09025	COG0105	UTP biosynthetic process
ISX45_09035	COG2226	methyltransferase
ISX45_09050	COG0302	gtp cyclohydrolase
ISX45_09060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ISX45_09075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISX45_09080	COG1160	GTP binding
ISX45_09110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISX45_09115	COG0697	spore germination
ISX45_09120	COG1304	FMN binding
ISX45_09125	COG0539	negative regulation of cytoplasmic translation
ISX45_09135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISX45_09145	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ISX45_09150	COG2959	enzyme of heme biosynthesis
ISX45_09155	COG3409	Peptidoglycan-binding domain 1 protein
ISX45_09155	COG3773	Cell wall hydrolase
ISX45_09160	COG2339	peptidase activity
ISX45_09165	COG0252	asparaginase activity
ISX45_09170	COG0492	ferredoxin-NADP+ reductase activity
ISX45_09175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISX45_09190	COG1408	metallophosphoesterase
ISX45_09210	COG3546	catalase activity
ISX45_09220	COG1733	regulation of RNA biosynthetic process
ISX45_09225	COG2814	Major facilitator Superfamily
ISX45_09230	COG0656	L-ascorbic acid biosynthetic process
ISX45_09245	COG1266	CAAX protease self-immunity
ISX45_09250	COG0514	ATP-dependent DNA helicase (RecQ)
ISX45_09255	COG4955	Helix-turn-helix domain
ISX45_09275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISX45_09280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ISX45_09290	COG1595	DNA-templated transcription, initiation
ISX45_09305	COG2096	Adenosyltransferase
ISX45_09320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ISX45_09325	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
ISX45_09330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISX45_09335	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ISX45_09340	COG1120	ATPase activity
ISX45_09345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_09350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_09380	COG2190	(PTS) system
ISX45_09380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX45_09380	COG1263	PTS System
ISX45_09385	COG2188	Transcriptional regulator
ISX45_09390	COG0363	glucosamine-6-phosphate deaminase activity
ISX45_09395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISX45_09400	COG4821	SIS domain
ISX45_09405	COG5002	protein histidine kinase activity
ISX45_09410	COG0745	RESPONSE REGULATOR receiver
ISX45_09415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISX45_09420	COG1333	cytochrome c biogenesis protein
ISX45_09425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_09430	COG1187	pseudouridine synthase activity
ISX45_09440	COG2801	Transposase and inactivated derivatives
ISX45_09445	COG0700	Nucleoside recognition
ISX45_09450	COG2715	membrane protein required for spore maturation
ISX45_09455	COG1686	Belongs to the peptidase S11 family
ISX45_09460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISX45_09480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISX45_09485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISX45_09490	COG1547	Domain of unknown function (DUF309)
ISX45_09500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISX45_09505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISX45_09505	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISX45_09510	COG0307	riboflavin synthase, alpha
ISX45_09515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISX45_09515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISX45_09520	COG2188	Transcriptional regulator
ISX45_09530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISX45_09535	COG4086	secreted protein
ISX45_09545	COG0697	spore germination
ISX45_09560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX45_09585	COG2172	sigma factor antagonist activity
ISX45_09595	COG1686	Belongs to the peptidase S11 family
ISX45_09615	COG4974	Belongs to the 'phage' integrase family
ISX45_09625	COG0735	belongs to the Fur family
ISX45_09630	COG1300	Membrane
ISX45_09635	COG1379	DNA repair
ISX45_09640	COG0494	nUDIX hydrolase
ISX45_09645	COG0667	Aldo Keto reductase
ISX45_09655	COG0295	cytidine deaminase activity
ISX45_09660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISX45_09670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISX45_09675	COG2390	Transcriptional regulator
ISX45_09690	COG4918	Iron-sulphur cluster biosynthesis
ISX45_09705	COG0300	oxidoreductase activity
ISX45_09710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX45_09715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISX45_09725	COG1902	pentaerythritol trinitrate reductase activity
ISX45_09730	COG1234	tRNA 3'-trailer cleavage
ISX45_09735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISX45_09740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISX45_09745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ISX45_09765	COG0726	polysaccharide deacetylase
ISX45_09770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISX45_09795	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISX45_09805	COG0456	acetyltransferase
ISX45_09810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISX45_09815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISX45_09820	COG0346	lactoylglutathione lyase activity
ISX45_09830	COG1376	ErfK ybiS ycfS ynhG family protein
ISX45_09835	COG4129	membrane
ISX45_09840	COG1126	abc transporter atp-binding protein
ISX45_09845	COG0765	amino acid transport
ISX45_09850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX45_09865	COG1703	isobutyryl-CoA mutase activity
ISX45_09870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_09870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_09875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_09875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_09880	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISX45_09885	COG0022	dehydrogenase e1 component
ISX45_09890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISX45_09895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISX45_09910	COG0280	phosphate acetyltransferase
ISX45_09915	COG3290	protein histidine kinase activity
ISX45_09915	COG3829	transcription factor binding
ISX45_09925	COG0584	glycerophosphoryl diester phosphodiesterase
ISX45_09930	COG3093	addiction module antidote protein HigA
ISX45_09950	COG0438	transferase activity, transferring glycosyl groups
ISX45_09970	COG1086	Polysaccharide biosynthesis protein
ISX45_09995	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ISX45_10010	COG0750	zinc metalloprotease
ISX45_10015	COG0497	DNA recombination
ISX45_10020	COG1438	arginine binding
ISX45_10025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ISX45_10030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISX45_10040	COG1722	exodeoxyribonuclease VII activity
ISX45_10045	COG1570	exodeoxyribonuclease VII activity
ISX45_10050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISX45_10055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISX45_10060	COG1302	Protein conserved in bacteria
ISX45_10065	COG0439	Biotin carboxylase
ISX45_10070	COG0511	ligase activity, forming carbon-carbon bonds
ISX45_10110	COG3854	ATPases associated with a variety of cellular activities
ISX45_10120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISX45_10125	COG0006	proline dipeptidase activity
ISX45_10130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISX45_10140	COG3872	metal-dependent enzyme
ISX45_10150	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISX45_10155	COG1321	iron dependent repressor
ISX45_10175	COG5002	protein histidine kinase activity
ISX45_10185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISX45_10210	COG0095	Lipoate-protein ligase
ISX45_10215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISX45_10225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISX45_10230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ISX45_10235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ISX45_10285	COG1598	PFAM Uncharacterised protein family UPF0150
ISX45_10355	COG1459	type II secretion system
ISX45_10360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISX45_10380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX45_10395	COG0011	TIGRFAM Protein of
ISX45_10405	COG1368	sulfuric ester hydrolase activity
ISX45_10410	COG1940	carbohydrate kinase activity
ISX45_10415	COG4483	Protein conserved in bacteria
ISX45_10420	COG0697	spore germination
ISX45_10430	COG0457	Tetratricopeptide repeat
ISX45_10430	COG0705	Rhomboid family
ISX45_10435	COG1011	Hydrolase
ISX45_10455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISX45_10460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISX45_10465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISX45_10480	COG0704	Plays a role in the regulation of phosphate uptake
ISX45_10490	COG0768	penicillin binding
ISX45_10495	COG0477	Major facilitator Superfamily
ISX45_10510	COG0840	transmembrane signaling receptor activity
ISX45_10515	COG5521	maltodextrose utilization protein MalA
ISX45_10520	COG0581	inorganic phosphate transmembrane transporter activity
ISX45_10525	COG0573	inorganic phosphate transmembrane transporter activity
ISX45_10530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISX45_10535	COG1388	LysM domain
ISX45_10540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ISX45_10545	COG4709	membrane
ISX45_10550	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ISX45_10555	COG0735	belongs to the Fur family
ISX45_10560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISX45_10565	COG1121	(ABC) transporter
ISX45_10580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ISX45_10595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISX45_10600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISX45_10605	COG2384	SAM-dependent methyltransferase
ISX45_10610	COG2010	Cytochrome c
ISX45_10620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISX45_10630	COG1671	Belongs to the UPF0178 family
ISX45_10635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISX45_10640	COG0517	IMP dehydrogenase activity
ISX45_10645	COG1381	Involved in DNA repair and RecF pathway recombination
ISX45_10655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISX45_10660	COG0295	cytidine deaminase activity
ISX45_10665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISX45_10670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ISX45_10675	COG1480	7TM receptor with intracellular HD hydrolase
ISX45_10680	COG1702	phosphate starvation-inducible protein PhoH
ISX45_10695	COG1610	YqeY-like protein
ISX45_10700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISX45_10705	COG1283	sodium-dependent phosphate transmembrane transporter activity
ISX45_10710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISX45_10715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISX45_10720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISX45_10725	COG2264	protein methyltransferase activity
ISX45_10730	COG0484	heat shock protein binding
ISX45_10735	COG0443	Heat shock 70 kDa protein
ISX45_10740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISX45_10745	COG1420	regulation of RNA biosynthetic process
ISX45_10750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISX45_10755	COG0481	GTPase activity
ISX45_10770	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX45_10775	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ISX45_10780	COG0268	Binds directly to 16S ribosomal RNA
ISX45_10785	COG1466	dna polymerase III delta subunit
ISX45_10795	COG0658	competence protein
ISX45_10795	COG2333	competence protein COMEC
ISX45_10800	COG2131	deaminase
ISX45_10805	COG1596	polysaccharide export
ISX45_10805	COG1555	photosystem II stabilization
ISX45_10810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISX45_10815	COG2226	methyltransferase
ISX45_10820	COG0799	negative regulation of ribosome biogenesis
ISX45_10825	COG1713	HD superfamily hydrolase involved in NAD metabolism
ISX45_10830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISX45_10835	COG1534	Rna-binding protein
ISX45_10840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISX45_10845	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ISX45_10850	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ISX45_10860	COG0688	phosphatidylethanolamine metabolic process
ISX45_10865	COG1183	phosphatidylcholine synthase activity
ISX45_10870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISX45_10875	COG1360	Flagellar Motor Protein
ISX45_10880	COG0628	permease
ISX45_10895	COG0586	Pfam SNARE associated Golgi protein
ISX45_10910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISX45_10915	COG1279	arginine transmembrane transporter activity
ISX45_10920	COG0384	phenazine biosynthesis protein PhzF
ISX45_10925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX45_10945	COG0626	cystathionine gamma-synthase activity
ISX45_10950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISX45_10955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISX45_10960	COG2226	methyltransferase
ISX45_10975	COG0768	penicillin binding
ISX45_10980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISX45_10985	COG0572	uridine kinase
ISX45_10990	COG0826	peptidase U32
ISX45_10995	COG0826	peptidase U32
ISX45_11000	COG4122	O-methyltransferase activity
ISX45_11005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISX45_11010	COG3906	Belongs to the UPF0473 family
ISX45_11015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISX45_11020	COG4472	Bacterial protein of unknown function (DUF965)
ISX45_11025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ISX45_11030	COG0628	permease
ISX45_11045	COG3881	PFAM PRC-barrel domain
ISX45_11050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISX45_11060	COG0482	sulfurtransferase activity
ISX45_11065	COG1104	cysteine desulfurase activity
ISX45_11070	COG1959	2 iron, 2 sulfur cluster binding
ISX45_11075	COG2364	Membrane
ISX45_11080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISX45_11085	COG1309	transcriptional regulator
ISX45_11090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX45_11100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISX45_11110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ISX45_11115	COG0124	histidyl-tRNA synthetase
ISX45_11125	COG3103	Sh3 type 3 domain protein
ISX45_11125	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX45_11125	COG4991	sh3 domain protein
ISX45_11130	COG1490	D-aminoacyl-tRNA deacylase activity
ISX45_11135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISX45_11140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISX45_11145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ISX45_11145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISX45_11150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISX45_11155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX45_11155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX45_11165	COG2244	polysaccharide biosynthetic process
ISX45_11175	COG1862	Preprotein translocase
ISX45_11180	COG0343	queuine tRNA-ribosyltransferase activity
ISX45_11185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISX45_11195	COG2255	four-way junction helicase activity
ISX45_11200	COG0632	four-way junction helicase activity
ISX45_11210	COG0217	transcriptional regulatory protein
ISX45_11220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISX45_11230	COG1388	LysM domain
ISX45_11235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ISX45_11240	COG0157	Belongs to the NadC ModD family
ISX45_11245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISX45_11250	COG1104	cysteine desulfurase activity
ISX45_11255	COG1827	regulation of RNA biosynthetic process
ISX45_11260	COG0494	nUDIX hydrolase
ISX45_11265	COG0077	Prephenate dehydratase
ISX45_11270	COG4492	Belongs to the UPF0735 family
ISX45_11275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISX45_11280	COG3290	protein histidine kinase activity
ISX45_11285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISX45_11290	COG2868	ribosomal protein
ISX45_11295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISX45_11300	COG1994	Peptidase M50
ISX45_11305	COG0739	heme binding
ISX45_11310	COG2894	cell division
ISX45_11315	COG0850	regulation of cytokinetic process
ISX45_11320	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISX45_11325	COG1792	Involved in formation and maintenance of cell shape
ISX45_11330	COG1077	Cell shape determining protein MreB Mrl
ISX45_11335	COG2003	Belongs to the UPF0758 family
ISX45_11340	COG0424	maF-like protein
ISX45_11370	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISX45_11380	COG1459	type II secretion system
ISX45_11390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISX45_11425	COG5492	domain, Protein
ISX45_11430	COG0285	dihydrofolate synthase activity
ISX45_11435	COG0525	valine-tRNA ligase activity
ISX45_11450	COG1388	LysM domain
ISX45_11450	COG1388	LysM domain
ISX45_11455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISX45_11460	COG0113	porphobilinogen synthase activity
ISX45_11465	COG1587	Uroporphyrinogen-III synthase
ISX45_11470	COG0181	hydroxymethylbilane synthase activity
ISX45_11475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISX45_11490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ISX45_11495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISX45_11500	COG0470	DNA polymerase III
ISX45_11500	COG1067	ATP-dependent peptidase activity
ISX45_11505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISX45_11510	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISX45_11520	COG0066	3-isopropylmalate dehydratase activity
ISX45_11525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISX45_11530	COG0473	3-isopropylmalate dehydrogenase activity
ISX45_11535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISX45_11540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISX45_11545	COG0440	acetolactate synthase activity
ISX45_11550	COG0028	Belongs to the TPP enzyme family
ISX45_11555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISX45_11565	COG0622	Phosphoesterase
ISX45_11570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISX45_11575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISX45_11580	COG5401	PFAM Sporulation and spore germination
ISX45_11585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISX45_11595	COG2197	response regulator
ISX45_11600	COG0824	Thioesterase
ISX45_11605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISX45_11610	COG1053	succinate dehydrogenase
ISX45_11615	COG2009	succinate dehydrogenase
ISX45_11620	COG1719	4-vinyl reductase, 4VR
ISX45_11630	COG0322	excinuclease ABC activity
ISX45_11650	COG0463	Glycosyl transferase, family 2
ISX45_11665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISX45_11680	COG0431	NADPH-dependent FMN reductase
ISX45_11685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX45_11690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISX45_11695	COG1116	anion transmembrane transporter activity
ISX45_11700	COG3118	belongs to the thioredoxin family
ISX45_11705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ISX45_11710	COG2086	electron transfer activity
ISX45_11715	COG1024	Enoyl-CoA hydratase
ISX45_11720	COG1309	transcriptional regulator
ISX45_11725	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_11730	COG3766	membrane
ISX45_11735	COG1193	negative regulation of DNA recombination
ISX45_11740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ISX45_11740	COG1796	DNA polymerase
ISX45_11745	COG1286	toxin biosynthetic process
ISX45_11750	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ISX45_11755	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ISX45_11765	COG1033	growth of symbiont in host cell
ISX45_11765	COG2409	Drug exporters of the RND superfamily
ISX45_11770	COG1846	Transcriptional regulator
ISX45_11785	COG3335	DDE superfamily endonuclease
ISX45_11790	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ISX45_11795	COG1131	(ABC) transporter
ISX45_11800	COG1131	(ABC) transporter
ISX45_11805	COG1725	Transcriptional regulator
ISX45_11820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISX45_11820	COG0072	phenylalanine-tRNA ligase activity
ISX45_11825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISX45_11835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISX45_11850	COG4106	trans-aconitate 2-methyltransferase activity
ISX45_11855	COG1363	Peptidase, m42
ISX45_11870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISX45_11875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ISX45_11885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ISX45_11895	COG1484	DNA-dependent DNA replication
ISX45_11900	COG3611	Membrane attachment protein
ISX45_11905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISX45_11915	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISX45_11920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISX45_11930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISX45_11940	COG5002	protein histidine kinase activity
ISX45_11945	COG0745	RESPONSE REGULATOR receiver
ISX45_11955	COG0039	L-malate dehydrogenase activity
ISX45_11960	COG0538	isocitrate dehydrogenase activity
ISX45_11965	COG0372	Belongs to the citrate synthase family
ISX45_11970	COG2707	UPF0756 membrane protein
ISX45_11975	COG0628	permease
ISX45_11980	COG3030	protein affecting phage T7 exclusion by the F plasmid
ISX45_11990	COG0205	6-phosphofructokinase activity
ISX45_11995	COG0825	malonyl-CoA metabolic process
ISX45_12000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISX45_12005	COG1725	Transcriptional regulator
ISX45_12010	COG0281	malic enzyme
ISX45_12015	COG0587	DNA-directed DNA polymerase activity
ISX45_12030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ISX45_12040	COG4109	DRTGG domain
ISX45_12045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISX45_12050	COG0006	proline dipeptidase activity
ISX45_12065	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_12075	COG0589	response to stress
ISX45_12080	COG0165	Argininosuccinate lyase
ISX45_12085	COG0137	argininosuccinate synthase activity
ISX45_12095	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISX45_12100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ISX45_12105	COG0827	DNA restriction-modification system
ISX45_12110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISX45_12115	COG3874	Sporulation protein YtfJ
ISX45_12125	COG1714	RDD family
ISX45_12130	COG0616	signal peptide processing
ISX45_12135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISX45_12140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISX45_12150	COG0301	tRNA thio-modification
ISX45_12155	COG1104	cysteine desulfurase activity
ISX45_12160	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ISX45_12165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ISX45_12170	COG1956	GAF domain-containing protein
ISX45_12175	COG2203	Gaf domain
ISX45_12175	COG2199	diguanylate cyclase activity
ISX45_12180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISX45_12190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX45_12195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISX45_12200	COG0454	-acetyltransferase
ISX45_12205	COG0517	IMP dehydrogenase activity
ISX45_12210	COG0123	including yeast histone deacetylase and acetoin utilization protein
ISX45_12225	COG1605	Chorismate mutase
ISX45_12225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ISX45_12230	COG0849	cell division
ISX45_12235	COG3118	belongs to the thioredoxin family
ISX45_12240	COG4980	gas vesicle protein
ISX45_12245	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ISX45_12250	COG2309	aminopeptidase activity
ISX45_12260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISX45_12270	COG1674	ftsk spoiiie
ISX45_12270	COG1674	ftsk spoiiie
ISX45_12275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISX45_12280	COG4848	Belongs to the UPF0354 family
ISX45_12285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_12290	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ISX45_12295	COG1363	Peptidase, m42
ISX45_12305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX45_12310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ISX45_12320	COG0510	thiamine kinase activity
ISX45_12325	COG1523	belongs to the glycosyl hydrolase 13 family
ISX45_12335	COG1346	cytolysis
ISX45_12340	COG1380	Effector of murein hydrolase LrgA
ISX45_12355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISX45_12360	COG1349	DNA-binding transcription factor activity
ISX45_12365	COG1187	pseudouridine synthase activity
ISX45_12375	COG2244	polysaccharide biosynthetic process
ISX45_12380	COG2081	HI0933 family
ISX45_12415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISX45_12420	COG0495	leucyl-tRNA aminoacylation
ISX45_12425	COG0640	Transcriptional regulator
ISX45_12430	COG2814	Major facilitator Superfamily
ISX45_12445	COG1242	4 iron, 4 sulfur cluster binding
ISX45_12450	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ISX45_12460	COG2267	carboxylic ester hydrolase activity
ISX45_12465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISX45_12470	COG4990	cell redox homeostasis
ISX45_12475	COG0367	asparagine synthase
ISX45_12480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISX45_12485	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ISX45_12495	COG1506	peptidase
ISX45_12500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISX45_12505	COG1116	anion transmembrane transporter activity
ISX45_12510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX45_12515	COG0494	nUDIX hydrolase
ISX45_12525	COG4824	toxin secretion phage lysis holin
ISX45_12530	COG0783	Belongs to the Dps family
ISX45_12545	COG0701	Predicted permease
ISX45_12550	COG1854	S-ribosylhomocysteine lyase activity
ISX45_12555	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISX45_12560	COG0288	reversible hydration of carbon dioxide
ISX45_12565	COG0523	cobalamin synthesis protein
ISX45_12590	COG0254	rRNA binding
ISX45_12595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISX45_12605	COG1271	oxidase subunit
ISX45_12610	COG1294	oxidase, subunit
ISX45_12645	COG4948	Mandelate Racemase Muconate Lactonizing
ISX45_12650	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_12655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISX45_12660	COG0596	Alpha beta hydrolase
ISX45_12665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ISX45_12670	COG1169	isochorismate synthase
ISX45_12675	COG1575	Belongs to the MenA family. Type 1 subfamily
ISX45_12680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISX45_12690	COG0058	SHG alpha-glucan phosphorylase activity
ISX45_12695	COG0297	glycogen (starch) synthase activity
ISX45_12705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ISX45_12855	COG1285	pathogenesis
ISX45_12875	COG1620	l-lactate permease
ISX45_12880	COG0039	L-malate dehydrogenase activity
ISX45_12895	COG2814	Major facilitator Superfamily
ISX45_12905	COG0840	transmembrane signaling receptor activity
ISX45_12910	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISX45_12915	COG1247	-acetyltransferase
ISX45_12930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISX45_12950	COG2340	Cysteine-rich secretory protein family
ISX45_12975	COG3335	DDE superfamily endonuclease
ISX45_12985	COG1280	lysine exporter protein (LysE YggA)
ISX45_13000	COG0402	S-adenosylhomocysteine deaminase activity
ISX45_13020	COG0531	amino acid
ISX45_13035	COG1979	alcohol dehydrogenase
ISX45_13040	COG2155	Conserved Protein
ISX45_13045	COG1098	S1 RNA binding domain
ISX45_13055	COG0436	Aminotransferase
ISX45_13060	COG1522	sequence-specific DNA binding
ISX45_13065	COG2267	carboxylic ester hydrolase activity
ISX45_13075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISX45_13080	COG2032	superoxide dismutase activity
ISX45_13090	COG5018	Exonuclease
ISX45_13095	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISX45_13120	COG1268	BioY protein
ISX45_13125	COG0306	phosphate transporter
ISX45_13130	COG1392	Phosphate transport regulator
ISX45_13135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISX45_13150	COG3584	3D domain protein
ISX45_13170	COG1252	NADH dehydrogenase
ISX45_13175	COG0492	ferredoxin-NADP+ reductase activity
ISX45_13180	COG5416	Lipopolysaccharide assembly protein A domain
ISX45_13185	COG2340	Cysteine-rich secretory protein family
ISX45_13205	COG0316	Belongs to the HesB IscA family
ISX45_13210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISX45_13220	COG4844	belongs to the
ISX45_13225	COG1252	NADH dehydrogenase
ISX45_13230	COG4837	Protein of unknown function (DUF1462)
ISX45_13235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISX45_13240	COG0083	homoserine kinase activity
ISX45_13245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISX45_13250	COG0460	homoserine dehydrogenase
ISX45_13255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISX45_13260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISX45_13265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISX45_13270	COG0647	UMP catabolic process
ISX45_13280	COG2445	Protein of unknown function DUF86
ISX45_13295	COG4470	Protein conserved in bacteria
ISX45_13305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISX45_13310	COG0739	heme binding
ISX45_13330	COG3377	Domain of unknown function (DUF1805)
ISX45_13335	COG0737	Belongs to the 5'-nucleotidase family
ISX45_13340	COG0730	response to heat
ISX45_13345	COG1801	Protein of unknown function DUF72
ISX45_13350	COG0719	Fe-S assembly protein
ISX45_13355	COG0822	iron-sulfur transferase activity
ISX45_13360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISX45_13365	COG0719	Fe-S assembly protein
ISX45_13370	COG0396	ATPase activity
ISX45_13375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISX45_13385	COG1464	Belongs to the NlpA lipoprotein family
ISX45_13390	COG2011	ABC-type metal ion transport system permease component
ISX45_13395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX45_13410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_13415	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ISX45_13425	COG0509	glycine decarboxylation via glycine cleavage system
ISX45_13430	COG1393	Belongs to the ArsC family
ISX45_13435	COG1960	acyl-CoA dehydrogenase activity
ISX45_13440	COG0183	Belongs to the thiolase family
ISX45_13445	COG1024	Enoyl-CoA hydratase
ISX45_13445	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_13455	COG0506	proline dehydrogenase activity
ISX45_13465	COG5577	PFAM Coat F domain
ISX45_13485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISX45_13490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISX45_13520	COG0753	catalase activity
ISX45_13585	COG1511	domain protein
ISX45_13590	COG1674	ftsk spoiiie
ISX45_13595	COG4499	WXG100 protein secretion system (Wss), protein YukC
ISX45_13600	COG5417	Belongs to the EsaB family
ISX45_13605	COG4842	Belongs to the WXG100 family
ISX45_13660	COG1388	LysM domain
ISX45_13660	COG3584	3D domain protein
ISX45_13670	COG0702	epimerase
ISX45_13680	COG0482	sulfurtransferase activity
ISX45_13685	COG1959	2 iron, 2 sulfur cluster binding
ISX45_13695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISX45_13700	COG0557	exoribonuclease II activity
ISX45_13710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISX45_13720	COG0148	phosphopyruvate hydratase activity
ISX45_13725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ISX45_13730	COG0149	triose-phosphate isomerase activity
ISX45_13735	COG0126	phosphoglycerate kinase activity
ISX45_13755	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISX45_13765	COG0740	serine-type endopeptidase activity
ISX45_13770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_13775	COG1481	regulation of sporulation
ISX45_13780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISX45_13785	COG1660	Displays ATPase and GTPase activities
ISX45_13790	COG1051	belongs to the nudix hydrolase family
ISX45_13795	COG0492	ferredoxin-NADP+ reductase activity
ISX45_13800	COG0457	Tetratricopeptide repeat
ISX45_13805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISX45_13805	COG0140	phosphoribosyl-ATP diphosphatase activity
ISX45_13810	COG0107	imidazoleglycerol-phosphate synthase activity
ISX45_13815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ISX45_13820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISX45_13825	COG0131	Imidazoleglycerol-phosphate dehydratase
ISX45_13830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISX45_13835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISX45_13840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ISX45_13860	COG0110	maltose O-acetyltransferase activity
ISX45_13865	COG0546	phosphoglycolate phosphatase activity
ISX45_13870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ISX45_13875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ISX45_13880	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ISX45_13885	COG1950	PFAM Membrane protein of
ISX45_13890	COG3595	metallopeptidase activity
ISX45_13900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISX45_13905	COG0556	nucleotide-excision repair
ISX45_13910	COG4897	Protein conserved in bacteria
ISX45_13915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX45_13920	COG0789	Transcriptional regulator
ISX45_13930	COG0463	Glycosyl transferase, family 2
ISX45_13940	COG0793	Belongs to the peptidase S41A family
ISX45_13940	COG3409	Peptidoglycan-binding domain 1 protein
ISX45_13950	COG1231	oxidoreductase activity
ISX45_13965	COG0411	ABC transporter
ISX45_13995	COG0640	Transcriptional regulator
ISX45_14005	COG3883	PFAM NLP P60 protein
ISX45_14005	COG0791	NLP P60 protein
ISX45_14010	COG2177	Part of the ABC transporter FtsEX involved in
ISX45_14015	COG2884	Cell division ATP-binding protein ftsE
ISX45_14030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_14040	COG0653	protein targeting
ISX45_14055	COG1516	flagellar protein fliS
ISX45_14060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISX45_14070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX45_14080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISX45_14085	COG2089	acid synthase
ISX45_14095	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ISX45_14125	COG1216	Glycosyl transferase, family 2
ISX45_14150	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISX45_14165	COG1216	Glycosyl transferase, family 2
ISX45_14170	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_14175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISX45_14180	COG1086	Polysaccharide biosynthesis protein
ISX45_14200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX45_14205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISX45_14220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX45_14225	COG4786	Flagellar basal body rod
ISX45_14225	COG1256	bacterial-type flagellum assembly
ISX45_14235	COG2747	anti-sigma28 factor FlgM
ISX45_14245	COG1728	Protein conserved in bacteria
ISX45_14260	COG1040	competence protein
ISX45_14265	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ISX45_14270	COG1307	EDD domain protein, DegV family
ISX45_14275	COG2197	response regulator
ISX45_14280	COG4585	Histidine kinase
ISX45_14285	COG1739	Uncharacterized protein family UPF0029
ISX45_14290	COG1316	TRANSCRIPTIONal
ISX45_14295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISX45_14300	COG0728	peptidoglycan biosynthetic process
ISX45_14315	COG0438	transferase activity, transferring glycosyl groups
ISX45_14325	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX45_14365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISX45_14370	COG4193	domain, Protein
ISX45_14375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX45_14380	COG0726	polysaccharide deacetylase
ISX45_14395	COG3764	Sortase (surface protein transpeptidase)
ISX45_14405	COG1063	alcohol dehydrogenase
ISX45_14410	COG4193	domain, Protein
ISX45_14475	COG0791	NLP P60 protein
ISX45_14495	COG0653	protein targeting
ISX45_14510	COG0728	peptidoglycan biosynthetic process
ISX45_14525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ISX45_14535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISX45_14540	COG1316	TRANSCRIPTIONal
ISX45_14550	COG1388	LysM domain
ISX45_14550	COG0791	NLP P60 protein
ISX45_14555	COG4715	Zinc finger, swim domain protein
ISX45_14560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ISX45_14570	COG1396	sequence-specific DNA binding
ISX45_14575	COG0629	single-stranded DNA binding
ISX45_14585	COG3764	Sortase (surface protein transpeptidase)
ISX45_14595	COG0527	aspartate kinase activity
ISX45_14610	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_14620	COG0477	Major facilitator Superfamily
ISX45_14625	COG1309	transcriptional regulator
ISX45_14635	COG1940	carbohydrate kinase activity
ISX45_14645	COG1175	transmembrane transport
ISX45_14650	COG1653	transport
ISX45_14655	COG2207	Transcriptional regulator
ISX45_14655	COG2207	Transcriptional regulator
ISX45_14655	COG4753	response regulator
ISX45_14655	COG4753	response regulator
ISX45_14660	COG2972	Histidine kinase
ISX45_14675	COG2723	6-phospho-beta-galactosidase activity
ISX45_14685	COG0673	inositol 2-dehydrogenase activity
ISX45_14695	COG1879	ABC-type sugar transport system periplasmic component
ISX45_14700	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISX45_14705	COG1129	ABC transporter
ISX45_14710	COG1869	D-ribose catabolic process
ISX45_14715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX45_14720	COG1609	Transcriptional regulator
ISX45_14730	COG1175	transmembrane transport
ISX45_14735	COG0395	ABC-type sugar transport system, permease component
ISX45_14745	COG1609	Transcriptional regulator
ISX45_14760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISX45_14770	COG4786	Flagellar basal body rod
ISX45_14775	COG4786	Flagellar basal body rod
ISX45_14780	COG1077	Cell shape determining protein MreB Mrl
ISX45_14785	COG1609	Transcriptional regulator
ISX45_14795	COG0405	Gamma-glutamyltransferase
ISX45_14800	COG0739	heme binding
ISX45_14805	COG2385	sporulation resulting in formation of a cellular spore
ISX45_14810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ISX45_14820	COG4836	Membrane
ISX45_14825	COG1007	ATP synthesis coupled electron transport
ISX45_14830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISX45_14835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISX45_14840	COG0713	ATP synthesis coupled electron transport
ISX45_14845	COG0839	Belongs to the complex I subunit 6 family
ISX45_14855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ISX45_14860	COG0649	NAD binding
ISX45_14865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISX45_14870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISX45_14875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISX45_14880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISX45_14885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ISX45_14890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ISX45_14895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISX45_14900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ISX45_14905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISX45_14915	COG0356	it plays a direct role in the translocation of protons across the membrane
ISX45_14930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISX45_14935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ISX45_14940	COG4475	Protein of unknown function (DUF436)
ISX45_14945	COG0698	ribose 5-phosphate isomerase
ISX45_14950	COG0840	transmembrane signaling receptor activity
ISX45_14960	COG1971	Probably functions as a manganese efflux pump
ISX45_14965	COG0009	L-threonylcarbamoyladenylate synthase
ISX45_14980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISX45_14990	COG2204	response regulator
ISX45_14995	COG5002	protein histidine kinase activity
ISX45_15010	COG1435	thymidine kinase activity
ISX45_15015	COG0254	rRNA binding
ISX45_15020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISX45_15025	COG1494	fructose-1,6-bisphosphatase
ISX45_15030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ISX45_15035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISX45_15045	COG2204	response regulator
ISX45_15055	COG4821	SIS domain
ISX45_15060	COG0504	CTP synthase activity
ISX45_15065	COG3343	RNA polymerase activity
ISX45_15070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_15070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_15070	COG1703	isobutyryl-CoA mutase activity
ISX45_15080	COG1960	acyl-CoA dehydrogenase activity
ISX45_15085	COG1960	acyl-CoA dehydrogenase activity
ISX45_15090	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_15095	COG0183	Belongs to the thiolase family
ISX45_15100	COG2181	nitrate reductase activity
ISX45_15100	COG0247	lactate metabolic process
ISX45_15105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISX45_15115	COG0018	arginyl-trna synthetase
ISX45_15120	COG4506	Protein conserved in bacteria
ISX45_15125	COG0010	Belongs to the arginase family
ISX45_15130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ISX45_15135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX45_15145	COG1994	Peptidase M50
ISX45_15155	COG2252	PERMEase
ISX45_15160	COG3465	dGTPase activity
ISX45_15165	COG1078	dGTPase activity
ISX45_15170	COG4844	belongs to the
ISX45_15180	COG0095	Lipoate-protein ligase
ISX45_15185	COG0280	phosphate acetyltransferase
ISX45_15190	COG3253	May function as heme-dependent peroxidase
ISX45_15195	COG3773	Cell wall hydrolase
ISX45_15205	COG2363	Small membrane protein
ISX45_15220	COG0366	Alpha amylase catalytic
ISX45_15225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISX45_15230	COG0423	glycine-tRNA ligase activity
ISX45_15235	COG1216	Glycosyl transferase, family 2
ISX45_15240	COG0697	spore germination
ISX45_15245	COG0477	Major facilitator Superfamily
ISX45_15250	COG4187	Peptidase family M20/M25/M40
ISX45_15255	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ISX45_15255	COG2508	Transcriptional regulator
ISX45_15260	COG0686	Belongs to the AlaDH PNT family
ISX45_15265	COG0351	phosphomethylpyrimidine kinase
ISX45_15270	COG3153	acetyltransferase
ISX45_15270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISX45_15280	COG0765	amino acid transport
ISX45_15300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISX45_15310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISX45_15320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISX45_15325	COG1113	amino acid transport
ISX45_15330	COG2197	response regulator
ISX45_15335	COG4585	Histidine kinase
ISX45_15345	COG1842	Phage shock protein A
ISX45_15360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISX45_15365	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_15365	COG1454	alcohol dehydrogenase
ISX45_15380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX45_15380	COG0723	plastoquinol--plastocyanin reductase activity
ISX45_15385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_15385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_15385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_15390	COG3711	transcriptional antiterminator
ISX45_15390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_15395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_15395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_15395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_15400	COG1482	cell wall glycoprotein biosynthetic process
ISX45_15410	COG3973	AAA domain
ISX45_15420	COG1929	Belongs to the glycerate kinase type-1 family
ISX45_15425	COG2610	gluconate transmembrane transporter activity
ISX45_15430	COG3835	regulator
ISX45_15435	COG1785	Belongs to the alkaline phosphatase family
ISX45_15440	COG2140	Oxalate decarboxylase
ISX45_15445	COG3118	belongs to the thioredoxin family
ISX45_15465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISX45_15475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX45_15480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISX45_15485	COG4853	Protein conserved in bacteria
ISX45_15490	COG4863	YycH protein
ISX45_15495	COG5002	protein histidine kinase activity
ISX45_15500	COG0745	RESPONSE REGULATOR receiver
ISX45_15505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISX45_15510	COG0305	Participates in initiation and elongation during chromosome replication
ISX45_15515	COG0359	binds to the 23S rRNA
ISX45_15520	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ISX45_15525	COG4241	membrane
ISX45_15530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISX45_15535	COG0629	single-stranded DNA binding
ISX45_15540	COG0360	Binds together with S18 to 16S ribosomal RNA
ISX45_15545	COG0012	GTP binding
ISX45_15550	COG0243	molybdopterin cofactor binding
ISX45_15555	COG4481	Protein conserved in bacteria
ISX45_15560	COG0668	transmembrane transport
ISX45_15575	COG1475	DNA binding
ISX45_15580	COG1192	Involved in chromosome partitioning
ISX45_15585	COG1475	DNA binding
ISX45_15590	COG0357	Ribosomal RNA small subunit methyltransferase G
ISX45_15595	COG0445	tRNA wobble uridine modification
ISX45_15600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ISX45_15605	COG1847	R3H domain protein
ISX45_15610	COG0706	membrane insertase activity
ISX45_15615	COG0594	ribonuclease P activity
ISX45_15620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ISX45_15625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ISX45_15630	COG0592	DNA-directed DNA polymerase activity
ISX45_15635	COG2501	S4 domain
ISX45_15640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISX45_15645	COG0187	DNA topoisomerase II activity
ISX45_15650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISX45_15690	COG0517	IMP dehydrogenase activity
ISX45_15690	COG0516	GMP reductase activity
ISX45_15700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ISX45_15705	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ISX45_15710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ISX45_15720	COG1428	Deoxynucleoside kinase
ISX45_15725	COG1428	Deoxynucleoside kinase
ISX45_15730	COG1388	LysM domain
ISX45_15730	COG3858	chitin binding
ISX45_15735	COG0590	tRNA wobble adenosine to inosine editing
ISX45_15745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISX45_15750	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ISX45_15755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ISX45_15800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX45_15805	COG0765	amino acid transport
ISX45_15810	COG0765	amino acid transport
ISX45_15820	COG1982	Orn Lys Arg decarboxylase major
ISX45_15825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISX45_15830	COG0470	DNA polymerase III
ISX45_15835	COG1774	PSP1 C-terminal conserved region
ISX45_15840	COG4467	Involved in initiation control of chromosome replication
ISX45_15845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ISX45_15850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISX45_15855	COG2002	toxin-antitoxin pair type II binding
ISX45_15865	COG0084	hydrolase, TatD family'
ISX45_15870	COG3584	3D domain protein
ISX45_15870	COG3583	domain protein
ISX45_15880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISX45_15890	COG4466	Protein conserved in bacteria
ISX45_15900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISX45_15905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISX45_15910	COG0251	oxidation-reduction process
ISX45_15915	COG2088	sporulation resulting in formation of a cellular spore
ISX45_15920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISX45_15930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ISX45_15935	COG0193	aminoacyl-tRNA hydrolase activity
ISX45_15945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISX45_15950	COG2002	toxin-antitoxin pair type II binding
ISX45_15955	COG2244	polysaccharide biosynthetic process
ISX45_15960	COG3956	TIGRFAM MazG family protein
ISX45_15965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISX45_15985	COG1098	S1 RNA binding domain
ISX45_16000	COG2208	phosphoserine phosphatase activity
ISX45_16005	COG2304	oxidoreductase activity
ISX45_16010	COG0515	serine threonine protein kinase
ISX45_16015	COG0037	tRNA processing
ISX45_16020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISX45_16025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISX45_16030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISX45_16035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISX45_16040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISX45_16045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISX45_16050	COG0512	Glutamine amidotransferase of anthranilate synthase
ISX45_16055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISX45_16060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISX45_16065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISX45_16070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISX45_16075	COG1396	sequence-specific DNA binding
ISX45_16080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISX45_16170	COG3880	PFAM UvrB UvrC protein
ISX45_16175	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ISX45_16180	COG0542	response to heat
ISX45_16185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISX45_16190	COG4956	integral membrane protein (PIN domain superfamily)
ISX45_16195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISX45_16200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISX45_16205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISX45_16210	COG1045	serine acetyltransferase
ISX45_16215	COG0215	cysteine-tRNA ligase activity
ISX45_16225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISX45_16230	COG3688	RNA-binding protein containing a PIN domain
ISX45_16240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISX45_16245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISX45_16250	COG0250	Participates in transcription elongation, termination and antitermination
ISX45_16260	COG0081	regulation of translation
ISX45_16265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ISX45_16270	COG0222	ribosome binding
ISX45_16275	COG2813	Specifically methylates the guanine in position
ISX45_16280	COG0085	RNA polymerase activity
ISX45_16285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISX45_16290	COG1358	cellular component organization or biogenesis
ISX45_16295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISX45_16300	COG0049	tRNA binding
ISX45_16305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISX45_16310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISX45_16315	COG0051	transcription antitermination factor activity, RNA binding
ISX45_16320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ISX45_16325	COG0088	Forms part of the polypeptide exit tunnel
ISX45_16330	COG0089	rRNA binding
ISX45_16335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISX45_16340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISX45_16345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ISX45_16350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISX45_16355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISX45_16360	COG0255	Belongs to the universal ribosomal protein uL29 family
ISX45_16365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISX45_16380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISX45_16385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISX45_16390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ISX45_16400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ISX45_16405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ISX45_16415	COG0200	Binds to the 23S rRNA
ISX45_16420	COG0201	protein transport
ISX45_16425	COG0563	adenylate kinase activity
ISX45_16430	COG0024	Methionine aminopeptidase
ISX45_16435	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ISX45_16440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISX45_16445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISX45_16450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ISX45_16455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ISX45_16460	COG0202	RNA polymerase activity
ISX45_16465	COG0203	ribosomal protein L17
ISX45_16470	COG1122	ATPase activity
ISX45_16475	COG1122	ATPase activity
ISX45_16480	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ISX45_16485	COG0101	tRNA pseudouridine synthase activity
ISX45_16490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ISX45_16495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ISX45_16505	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX45_16510	COG0489	protein tyrosine kinase activity
ISX45_16520	COG2194	sulfuric ester hydrolase activity
ISX45_16525	COG0726	polysaccharide deacetylase
ISX45_16600	COG1595	DNA-templated transcription, initiation
ISX45_16605	COG5662	AntiSigma factor
ISX45_16610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ISX45_16615	COG4856	YbbR-like protein
ISX45_16620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISX45_16625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISX45_16640	COG1136	(ABC) transporter
ISX45_16650	COG0745	RESPONSE REGULATOR receiver
ISX45_16665	COG2205	protein histidine kinase activity
ISX45_16675	COG3335	DDE superfamily endonuclease
ISX45_16680	COG1819	glycosyl
ISX45_16695	COG1247	-acetyltransferase
ISX45_16740	COG1960	acyl-CoA dehydrogenase activity
ISX45_16755	COG0778	Nitroreductase
ISX45_16760	COG2259	Doxx family
ISX45_16770	COG0789	Transcriptional regulator
ISX45_16775	COG2207	Transcriptional regulator
ISX45_16790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISX45_16795	COG0745	RESPONSE REGULATOR receiver
ISX45_16800	COG3850	Histidine kinase
ISX45_16800	COG2205	protein histidine kinase activity
ISX45_16800	COG3437	response regulator, receiver
ISX45_16800	COG4999	Histidine kinase
ISX45_16820	COG0500	methyltransferase
ISX45_16825	COG0789	Transcriptional regulator
ISX45_16850	COG2318	DinB family
ISX45_16855	COG1396	sequence-specific DNA binding
ISX45_16855	COG1917	Cupin 2, conserved barrel domain protein
ISX45_16880	COG2197	response regulator
ISX45_16890	COG1131	(ABC) transporter
ISX45_16900	COG0842	Transport permease protein
ISX45_16910	COG1404	Belongs to the peptidase S8 family
ISX45_16920	COG1368	sulfuric ester hydrolase activity
ISX45_16930	COG1968	undecaprenyl-diphosphatase activity
ISX45_16940	COG0531	amino acid
ISX45_16945	COG1971	Probably functions as a manganese efflux pump
ISX45_16960	COG2197	response regulator
ISX45_16965	COG0431	NADPH-dependent FMN reductase
ISX45_16975	COG1960	acyl-CoA dehydrogenase activity
ISX45_16995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX45_17015	COG0018	arginyl-trna synthetase
ISX45_17020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISX45_17030	COG0586	Pfam SNARE associated Golgi protein
ISX45_17035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISX45_17045	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISX45_17050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISX45_17060	COG0513	Belongs to the DEAD box helicase family
ISX45_17065	COG3402	PFAM membrane-flanked domain
ISX45_17070	COG3428	Bacterial PH domain
ISX45_17075	COG0705	Rhomboid family
ISX45_17080	COG0736	holo-[acyl-carrier-protein] synthase activity
ISX45_17085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ISX45_17090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISX45_17095	COG0864	Transcriptional regulator
ISX45_17100	COG2337	Toxic component of a toxin-antitoxin (TA) module
ISX45_17105	COG2183	response to ionizing radiation
ISX45_17115	COG3091	SprT-like family
ISX45_17200	COG0802	atpase or kinase
ISX45_17205	COG1214	PFAM Peptidase M22, glycoprotease
ISX45_17210	COG0456	acetyltransferase
ISX45_17215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ISX45_17220	COG0488	(ABC) transporter
ISX45_17225	COG0315	cyclic pyranopterin monophosphate synthase activity
ISX45_17230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ISX45_17235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISX45_17240	COG0805	protein transport
ISX45_17250	COG1266	CAAX protease self-immunity
ISX45_17255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ISX45_17260	COG0459	protein refolding
ISX45_17285	COG0459	protein refolding
ISX45_17295	COG0714	Associated with various cellular activities
ISX45_17300	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ISX45_17305	COG1305	Transglutaminase-like
ISX45_17310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISX45_17310	COG0519	Catalyzes the synthesis of GMP from XMP
ISX45_17315	COG2252	PERMEase
ISX45_17320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX45_17345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISX45_17350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISX45_17355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISX45_17360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ISX45_17365	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISX45_17370	COG0047	phosphoribosylformylglycinamidine synthase activity
ISX45_17375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISX45_17380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISX45_17385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ISX45_17390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISX45_17395	COG0138	bifunctional purine biosynthesis protein purh
ISX45_17400	COG0151	Belongs to the GarS family
ISX45_17410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ISX45_17415	COG1470	cell adhesion involved in biofilm formation
ISX45_17420	COG4496	protein, YerC YecD
ISX45_17425	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ISX45_17435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISX45_17440	COG4851	CamS sex pheromone cAM373 precursor
ISX45_17445	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_17460	COG3335	DDE superfamily endonuclease
ISX45_17485	COG1131	(ABC) transporter
ISX45_17505	COG1132	(ABC) transporter
ISX45_17520	COG1522	sequence-specific DNA binding
ISX45_17525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ISX45_17530	COG0154	amidase activity
ISX45_17535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ISX45_17540	COG1174	glycine betaine transport
ISX45_17545	COG1125	glycine betaine transport
ISX45_17545	COG0517	IMP dehydrogenase activity
ISX45_17585	COG1518	maintenance of DNA repeat elements
ISX45_17590	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISX45_17620	COG3842	ATPase activity
ISX45_17625	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISX45_17635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISX45_17640	COG2329	Antibiotic biosynthesis monooxygenase
ISX45_17645	COG1842	Phage shock protein A
ISX45_17655	COG5002	protein histidine kinase activity
ISX45_17665	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISX45_17670	COG2268	Band 7 protein
ISX45_17675	COG1597	lipid kinase activity
ISX45_17715	COG2966	Psort location CytoplasmicMembrane, score
ISX45_17720	COG3610	response to peptide
ISX45_17745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX45_17760	COG0789	Transcriptional regulator
ISX45_17760	COG4978	Transcriptional regulator
ISX45_17780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX45_17805	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ISX45_17810	COG5002	protein histidine kinase activity
ISX45_17825	COG3290	protein histidine kinase activity
ISX45_17825	COG0840	transmembrane signaling receptor activity
ISX45_17830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ISX45_17840	COG2814	Major facilitator Superfamily
ISX45_17845	COG0789	Transcriptional regulator
ISX45_17850	COG1511	domain protein
ISX45_17855	COG1511	domain protein
ISX45_17860	COG2080	2 iron, 2 sulfur cluster binding
ISX45_17870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISX45_17875	COG2068	MobA-Related Protein
ISX45_17880	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ISX45_17885	COG0604	alcohol dehydrogenase
ISX45_17910	COG2986	histidine ammonia-lyase
ISX45_17915	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISX45_17920	COG1228	amidohydrolase
ISX45_17925	COG0010	Belongs to the arginase family
ISX45_17940	COG0861	Integral membrane protein TerC family
ISX45_17950	COG1556	Lactate utilization protein
ISX45_17955	COG1139	Iron-sulfur cluster binding protein
ISX45_17960	COG0247	lactate metabolic process
ISX45_17965	COG2186	Transcriptional regulator
ISX45_17970	COG1620	l-lactate permease
ISX45_17980	COG1077	Cell shape determining protein MreB Mrl
ISX45_17990	COG1388	LysM domain
ISX45_17990	COG0791	NLP P60 protein
ISX45_17995	COG3300	MHYT domain
ISX45_17995	COG5001	Diguanylate cyclase
ISX45_18010	COG0745	RESPONSE REGULATOR receiver
ISX45_18015	COG2205	protein histidine kinase activity
ISX45_18015	COG2770	Histidine kinase
ISX45_18025	COG0384	phenazine biosynthesis protein PhzF
ISX45_18040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISX45_18045	COG0010	Belongs to the arginase family
ISX45_18050	COG1254	Belongs to the acylphosphatase family
ISX45_18075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISX45_18080	COG0529	Catalyzes the synthesis of activated sulfate
ISX45_18085	COG2046	Belongs to the sulfate adenylyltransferase family
ISX45_18090	COG0306	phosphate transporter
ISX45_18095	COG0175	sulfate reduction
ISX45_18110	COG4840	Belongs to the UPF0435 family
ISX45_18115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISX45_18125	COG1295	ribonuclease BN
ISX45_18135	COG0477	Major facilitator Superfamily
ISX45_18145	COG0387	Pfam Sodium calcium exchanger
ISX45_18155	COG0535	radical SAM domain protein
ISX45_18170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISX45_18175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISX45_18195	COG1309	transcriptional regulator
ISX45_18240	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_18270	COG0840	transmembrane signaling receptor activity
ISX45_18275	COG0835	chemotaxis
ISX45_18295	COG2197	response regulator
ISX45_18325	COG1090	epimerase
ISX45_18330	COG2137	regulation of response to DNA damage stimulus
ISX45_18360	COG1988	membrane-bound metal-dependent
ISX45_18370	COG3383	formate dehydrogenase (NAD+) activity
ISX45_18375	COG5609	conserved protein (DUF2294)
ISX45_18380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ISX45_18385	COG2116	formate transmembrane transporter activity
ISX45_18400	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_18415	COG3557	Belongs to the UPF0374 family
ISX45_18420	COG1132	(ABC) transporter
ISX45_18430	COG0444	Belongs to the ABC transporter superfamily
ISX45_18435	COG4608	Belongs to the ABC transporter superfamily
ISX45_18440	COG0747	negative chemotaxis
ISX45_18445	COG0601	transmembrane transport
ISX45_18450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX45_18455	COG4129	membrane
ISX45_18460	COG0067	glutamate synthase
ISX45_18460	COG0069	glutamate synthase activity
ISX45_18460	COG0070	glutamate synthase
ISX45_18465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISX45_18470	COG4555	ABC transporter
ISX45_18485	COG0577	efflux transmembrane transporter activity
ISX45_18490	COG1136	(ABC) transporter
ISX45_18495	COG2205	protein histidine kinase activity
ISX45_18500	COG0745	RESPONSE REGULATOR receiver
ISX45_18510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISX45_18515	COG0735	belongs to the Fur family
ISX45_18625	COG4974	Belongs to the 'phage' integrase family
ISX45_18730	COG0204	Acyl-transferase
ISX45_18735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX45_18740	COG0583	DNA-binding transcription factor activity
ISX45_18760	COG2318	DinB family
ISX45_18780	COG0384	phenazine biosynthesis protein PhzF
ISX45_18795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_18795	COG2207	Transcriptional regulator
ISX45_18800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_18805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_18810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_18815	COG0778	Nitroreductase
ISX45_18820	COG2819	hydrolase of the alpha beta superfamily
ISX45_18825	COG2819	hydrolase of the alpha beta superfamily
ISX45_18845	COG3382	B3 4 domain protein
ISX45_18860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISX45_18865	COG2766	serine protein kinase
ISX45_18875	COG3177	Filamentation induced by cAMP protein fic
ISX45_18915	COG0582	viral genome integration into host DNA
ISX45_18975	COG3331	DNA recombination
ISX45_19075	COG0740	serine-type endopeptidase activity
ISX45_19205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair