locus-tag class description CA592_00035 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CA592_00085 ENOG4105D5G Transposase CA592_00120 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) CA592_00125 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) CA592_00140 ENOG4105D7V transposase CA592_00150 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CA592_00155 ENOG4105CZN Potassium uptake protein CA592_00160 ENOG4105ER2 Ompa motb domain protein CA592_00165 ENOG4105E14 MotA TolQ exbB proton channel CA592_00170 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CA592_00175 ENOG4105DJ4 phosphatidylserine decarboxylase CA592_00185 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CA592_00190 ENOG4105CQW ribosome biogenesis GTPase YqeH CA592_00195 ENOG4105E2X shikimate dehydrogenase CA592_00200 ENOG410812S Rna-binding protein CA592_00205 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CA592_00210 ENOG4108WF2 Metal Dependent Phosphohydrolase CA592_00220 ENOG4105DXX methyltransferase CA592_00230 ENOG4105KQC Competence protein CA592_00235 ENOG4108UK2 deaminase CA592_00240 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CA592_00250 ENOG4105TQK DNA polymerase iii, delta' subunit CA592_00260 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CA592_00265 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) CA592_00270 ENOG4108ZRV stage ii sporulation protein p CA592_00280 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CA592_00285 ENOG4105CSA Coproporphyrinogen iii oxidase CA592_00290 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CA592_00295 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CA592_00300 ENOG4105CFG Acts as a chaperone (By similarity) CA592_00305 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CA592_00310 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CA592_00315 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CA592_00320 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CA592_00325 ENOG4105VCC 30S ribosomal protein S21 CA592_00330 ENOG4105KTH gatB Yqey CA592_00335 ENOG4105F7J membrane-bound serine protease CA592_00340 ENOG4105DI5 UPF0365 protein CA592_00350 ENOG41068P3 sporulation protein YqfC CA592_00360 ENOG4105C9A Phoh family CA592_00365 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CA592_00370 ENOG4107YR5 Diacylglycerol kinase CA592_00375 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CA592_00385 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) CA592_00395 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CA592_00405 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CA592_00425 ENOG4105EGD dinuclear metal center protein, YbgI family CA592_00430 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CA592_00445 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CA592_00455 ENOG4108JYZ YitT family CA592_00460 ENOG4105FDK ABC transporter CA592_00465 ENOG4105FAV ABC, transporter CA592_00470 ENOG4105N80 Ferric uptake regulator, Fur family CA592_00475 ENOG4108U5J '-nucleotidase CA592_00480 ENOG41063Y9 CA592_00485 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CA592_00530 ENOG4107RF6 penicillin-binding protein CA592_00535 ENOG4105EXS phosphate abc transporter CA592_00540 ENOG4105C8U phosphate abc transporter CA592_00545 ENOG4105E2Z phosphate ABC transporter (Permease CA592_00550 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CA592_00555 ENOG4108UTW Plays a role in the regulation of phosphate uptake CA592_00575 ENOG4105WDJ 50S ribosomal protein L33 CA592_00580 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CA592_00585 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CA592_00595 ENOG4107ZXI Rhomboid family CA592_00615 ENOG4105DKQ ROK family CA592_00620 ENOG4105E0M Sulfatase CA592_00635 ENOG4105C5X domain protein CA592_00665 ENOG4106855 Competence protein CA592_00705 ENOG4105C0D helicase CA592_00710 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CA592_00715 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CA592_00720 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CA592_00750 ENOG4105BZU Histidine kinase CA592_00760 ENOG4105WZW rhodanese family CA592_00765 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CA592_00770 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CA592_00780 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CA592_00790 ENOG4105KST dependent repressor CA592_00805 ENOG4105CBJ Metal-dependent enzyme CA592_00815 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CA592_00820 ENOG4105DC7 peptidase M24 CA592_00825 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CA592_00835 ENOG4105CD2 stage iii sporulation protein aa CA592_00840 ENOG4105KR5 Stage iii sporulation protein CA592_00845 ENOG4108CQH stage III sporulation protein AC CA592_00850 ENOG4105KQ4 Stage iii sporulation protein ad CA592_00860 ENOG410644B Stage III sporulation protein af CA592_00880 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CA592_00885 ENOG4108ZSR alkaline shock protein CA592_00890 ENOG4105M7K Involved in the transcription termination process (By similarity) CA592_00895 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CA592_00900 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CA592_00905 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CA592_00920 ENOG4105DX0 Hemolysin A CA592_00930 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CA592_00935 ENOG4105S1Z Stage IV sporulation protein B CA592_00950 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CA592_00955 ENOG4106CCJ Protein of unknown function (DUF2627) CA592_00960 ENOG4108JUB Transcriptional regulator CA592_00975 ENOG4105CKM Branched-chain carboxylic acid kinase CA592_00995 ENOG4105C7S Dehydrogenase CA592_01005 ENOG4105D5P Methylmalonyl-coA mutase CA592_01015 ENOG4108QEG Membrane CA592_01025 ENOG4108ZVT methylmalonyl-coA epimerase CA592_01030 ENOG4108HNZ carboxyl transferase CA592_01035 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CA592_01040 ENOG4108V3W Chemotaxis protein, CheW CA592_01045 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CA592_01050 ENOG4107XCH Cyclase family CA592_01055 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CA592_01060 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CA592_01080 ENOG4105II7 pyrroline-5-carboxylate reductase CA592_01085 ENOG41069FQ Metallo-beta-lactamase superfamily CA592_01090 ENOG4108IXY short-chain dehydrogenase reductase CA592_01095 ENOG4106HZJ CA592_01110 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E CA592_01120 ENOG4105D5G Transposase CA592_01125 ENOG4105DQQ Major facilitator superfamily MFS_1 CA592_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CA592_01135 ENOG4105E0C molybdate abc transporter CA592_01140 ENOG4108IJ6 ABC transporter CA592_01145 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CA592_01150 ENOG4105EPU Molybdenum cofactor synthesis domain protein CA592_01155 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CA592_01160 ENOG4105CVM Molybdenum cofactor synthesis domain protein CA592_01180 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CA592_01185 ENOG4105D06 uba thif-type nad fad binding protein CA592_01190 ENOG4107V6Q Cyclic nucleotide-binding domain CA592_01205 ENOG4108IUE nitrate reductase beta subunit CA592_01210 ENOG4105R3A Nitrate reductase CA592_01235 ENOG4105CPC Aldo Keto reductase CA592_01240 ENOG4108YZ4 nudix hydrolase CA592_01245 ENOG4105MZ9 stage II sporulation protein m CA592_01250 ENOG4105I3K Ferric uptake regulator, Fur family CA592_01265 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CA592_01285 ENOG4105DZ1 carboxypeptidase CA592_01290 ENOG41082AN stage II sporulation protein CA592_01295 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CA592_01300 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CA592_01320 ENOG4105CZ3 stage V sporulation protein ad CA592_01330 ENOG4105G6R Stage v sporulation protein ae CA592_01340 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CA592_01350 ENOG4105PTM secreted protein CA592_01355 ENOG4107ZE5 PPIases accelerate the folding of proteins CA592_01360 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CA592_01365 ENOG4108R6K riboflavin synthase, subunit alpha CA592_01370 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CA592_01375 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CA592_01390 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CA592_01395 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CA592_01405 ENOG4105C5W Aldolase CA592_01440 ENOG4105DZ1 carboxypeptidase CA592_01445 ENOG4108JIC nucleoside recognition domain protein CA592_01460 ENOG4105FE9 pseudouridine synthase CA592_01465 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CA592_01470 ENOG4107TWT Cytochrome c biogenesis protein CA592_01475 ENOG4105CRE cytochrome C CA592_01480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CA592_01485 ENOG4105BZU Histidine kinase CA592_01490 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CA592_01495 ENOG4105EHG Permease protein CA592_01500 ENOG4105E0A ABC, transporter CA592_01515 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CA592_01520 ENOG4105CIH Imidazole acetol-phosphate transaminase CA592_01530 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CA592_01545 ENOG4108WBT adenosyltransferase CA592_01565 ENOG4107RVV histidinol phosphate phosphatase, hisj family CA592_01570 ENOG4108JQ1 Dehydrogenase CA592_01585 ENOG4105T7X CA592_01590 ENOG4105C9U ATP-dependent DNA helicase RecQ CA592_01595 ENOG4105I7S Abortive infection protein CA592_01615 ENOG4107RGJ metallophosphoesterase CA592_01620 ENOG4108XDN Transcriptional regulator CA592_01625 ENOG4108S6Z Negative regulator of genetic competence CA592_01640 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CA592_01645 ENOG4105MSI germination protein ypeb CA592_01650 ENOG4105F0V Cell wall hydrolase CA592_01660 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) CA592_01675 ENOG4105CAT Cytidine monophosphate kinase CA592_01680 ENOG4105E9Q Acyl-transferase CA592_01685 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CA592_01690 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CA592_01710 ENOG4105S2F CA592_01715 ENOG41065D1 CA592_01720 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CA592_01725 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CA592_01740 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CA592_01750 ENOG4105EUJ GTP cyclohydrolase i CA592_01755 ENOG4105WP2 Tryptophan RNA-binding attenuator protein CA592_01760 ENOG4105XXQ heptaprenyl diphosphate synthase component I CA592_01765 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CA592_01775 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CA592_01780 ENOG4105BZU Histidine kinase CA592_01785 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CA592_01790 ENOG4105D49 3-dehydroquinate synthase CA592_01795 ENOG4105KHN chorismate mutase CA592_01805 ENOG4108I0Q anthranilate phosphoribosyltransferase CA592_01810 ENOG4105DK0 Indole-3-glycerol phosphate synthase CA592_01815 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CA592_01820 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CA592_01825 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CA592_01830 ENOG4105CIH Imidazole acetol-phosphate transaminase CA592_01840 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CA592_01845 ENOG41068YB TPR repeat-containing protein CA592_01850 ENOG4108SXZ UPF0302 protein CA592_01860 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CA592_01865 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CA592_01870 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit CA592_01885 ENOG4108JYZ YitT family CA592_01890 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CA592_01895 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CA592_01900 ENOG4108Z5K methylglyoxal synthase CA592_01905 ENOG4105FJR Lmbe family CA592_01910 ENOG4105CPK Glycosyl transferase (Group 1 CA592_01915 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CA592_01925 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CA592_01930 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CA592_01935 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CA592_01940 ENOG4105DVT helicase CA592_01950 ENOG4105YAC CA592_01965 ENOG4105C5S asparaginyl-tRNA synthetase CA592_01975 ENOG4105CSM endonuclease III CA592_01990 ENOG4105BZ4 penicillin-binding protein CA592_01995 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CA592_02025 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CA592_02030 ENOG4105EU9 CA592_02035 ENOG4105MYT Heat shock protein CA592_02075 ENOG4105BZU Histidine kinase CA592_02080 ENOG4105E0A ABC, transporter CA592_02100 ENOG4105DQ5 transport system permease protein CA592_02105 ENOG4105EHG Permease protein CA592_02110 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CA592_02115 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CA592_02120 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CA592_02125 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CA592_02140 ENOG4105CFI type iii restriction protein res subunit CA592_02200 ENOG4105C0D helicase CA592_02250 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CA592_02265 ENOG4105C4R Atp-dependent dna helicase CA592_02305 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) CA592_02310 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CA592_02325 ENOG4108HKT sucrose-6-phosphate hydrolase CA592_02345 ENOG4105BZU Histidine kinase CA592_02350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CA592_02400 ENOG4105VPX protein, conserved in bacteria CA592_02405 ENOG4105C59 p-type ATPase CA592_02440 ENOG4105CAQ asparagine synthetase CA592_02465 ENOG4105C5Q Transcriptional regulator CA592_02470 ENOG4105CBC glutamate synthase CA592_02475 ENOG4105BZ8 glutamate synthase CA592_02480 ENOG4105C01 Dihydroxy-acid dehydratase CA592_02500 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CA592_02505 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CA592_02520 ENOG4108IUX (ABC) transporter CA592_02570 ENOG4108UT2 hemolysin iii CA592_02590 ENOG4105DWD nucleoside recognition domain protein CA592_02600 ENOG4107R7I amino acid CA592_02605 ENOG4105DSE periplasmic solute binding protein CA592_02610 ENOG4105DIK (ABC) transporter CA592_02615 ENOG4105CC5 ABC transporter CA592_02620 ENOG4105CC5 ABC transporter CA592_02640 ENOG4105CDW Resistance protein CA592_02665 ENOG4108UZ3 Transporter CA592_02670 ENOG4105DTQ mandelate racemase muconate lactonizing CA592_02710 ENOG4105BZ1 (ABC) transporter CA592_02715 ENOG4105BZ1 (ABC) transporter CA592_02765 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CA592_02810 ENOG4105DVT helicase CA592_02815 ENOG4105KTU Transcriptional regulator, arsr family CA592_02855 ENOG4105CJ1 ABC, transporter CA592_02865 ENOG4107Y9E nuclease CA592_02870 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CA592_02875 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CA592_02880 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CA592_02885 ENOG4105CGU Enoyl-CoA hydratase CA592_02900 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) CA592_02910 ENOG4105BZU Histidine kinase CA592_02925 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CA592_02930 ENOG4105DVT helicase CA592_02935 ENOG4105CTD carboxy-peptidase CA592_02945 ENOG4107RQ2 Cytochrome c oxidase, subunit I CA592_02950 ENOG4105NAA Cytochrome C oxidase, subunit II CA592_02970 ENOG410890F Dynamin family CA592_02985 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CA592_02995 ENOG41075ZD Small, acid-soluble spore protein N CA592_03000 ENOG41067CD Small, acid-soluble spore protein Tlp CA592_03010 ENOG4105W8X HesB YadR YfhF-family protein CA592_03030 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CA592_03045 ENOG4108N23 SpoOM-related protein CA592_03050 ENOG4106Z5R CA592_03080 ENOG4108VXD carboxy-peptidase CA592_03100 ENOG4105FR1 rard protein CA592_03125 ENOG4105BZU Histidine kinase CA592_03135 ENOG4105WEF catalase CA592_03140 ENOG4105C7B Threonine dehydratase CA592_03160 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CA592_03165 ENOG4105DVE abc transporter atp-binding protein CA592_03175 ENOG4105CFP Peptidase U32 CA592_03185 ENOG4105VEQ Cold shock protein CA592_03195 ENOG41090WU lipolytic protein G-D-S-L family CA592_03200 ENOG4105CJ1 ABC, transporter CA592_03205 ENOG4108TU7 Inherit from COG: (ABC) transporter CA592_03225 ENOG4108B1Q Ribonuclease CA592_03230 ENOG4107QRP cobalamin biosynthesis protein CobW CA592_03255 ENOG4105E1F short-chain dehydrogenase reductase CA592_03345 ENOG4107T89 von Willebrand factor, type A CA592_03350 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CA592_03355 ENOG4105XTG Pfam:DUF156 CA592_03365 ENOG4105CIY formyltetrahydrofolate deformylase CA592_03375 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CA592_03380 ENOG4105WDJ 50S ribosomal protein L33 CA592_03395 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CA592_03400 ENOG4105K4P CoA-binding domain protein CA592_03405 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CA592_03410 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CA592_03420 ENOG41090WU lipolytic protein G-D-S-L family CA592_03425 ENOG4108KF3 Electron transport protein SCO1 SenC CA592_03440 ENOG4105C7B Threonine dehydratase CA592_03445 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CA592_03450 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CA592_03455 ENOG4105C45 hydrogenase expression formation protein (HypE) CA592_03460 ENOG4105CQS hydrogenase expression formation protein HypD CA592_03475 ENOG4107RSS Hydrogenase accessory protein HypB CA592_03480 ENOG41082RJ Hydrogenase nickel insertion protein HypA CA592_03490 ENOG4108USZ hydrogenase CA592_03535 ENOG4105E3S small subunit CA592_03540 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CA592_03545 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CA592_03560 ENOG4107YX5 Pfam:DUF548 CA592_03565 ENOG4108Y6J UPF0403 protein CA592_03575 ENOG4105CVG Homoserine O-transsuccinylase CA592_03605 ENOG4105P4J Allophanate hydrolase, subunit 1 CA592_03620 ENOG4107K5X Membrane-bound metal-dependent hydrolase CA592_03640 ENOG4105EXQ uroporphyrinogen iii synthase hem4 CA592_03645 ENOG4105BZU Histidine kinase CA592_03650 ENOG4105NQC Flavodoxin CA592_03660 ENOG4105DM4 PTS System CA592_03665 ENOG4105DE4 1-phosphofructokinase CA592_03670 ENOG4105E98 transcriptional regulator DeoR family CA592_03695 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CA592_03700 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CA592_03705 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme CA592_03760 ENOG4108I0Z Aconitate hydratase CA592_03765 ENOG410746C Acid-soluble spore protein O CA592_03790 ENOG4107YTP response regulator receiver protein CA592_03795 ENOG4107QIV Cytochrome c biogenesis protein CA592_03800 ENOG4105VXM UPF0154 protein CA592_03810 ENOG4105VPS UPF0291 protein CA592_03815 ENOG4108SVB resolvase CA592_03820 ENOG41067Z0 domain protein CA592_03825 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CA592_03830 ENOG4105C5F glutamine synthetase CA592_03835 ENOG4105KV4 Transcriptional regulator CA592_03840 ENOG4105CXI aluminum resistance protein CA592_03845 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CA592_03850 ENOG4105EN6 Membrane CA592_03860 ENOG4106F1P AAA ATPase, central domain protein CA592_03865 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CA592_03870 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CA592_03875 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CA592_03880 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CA592_03900 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CA592_03905 ENOG4105DQU oxidoreductase, subunit beta CA592_03910 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CA592_03915 ENOG4108IGT Dipeptidase CA592_03920 ENOG4105MCT stage V sporulation protein S CA592_03925 ENOG4105D48 metallophosphoesterase CA592_03930 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) CA592_03935 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CA592_03940 ENOG4105CEV competence damage-inducible protein CA592_03945 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CA592_03960 ENOG4105XZV Protein of unknown function (DUF3243) CA592_03965 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CA592_03985 ENOG4105C6T cysteine synthase CA592_03995 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) CA592_04015 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CA592_04025 ENOG4105V75 Transcriptional regulator CA592_04050 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CA592_04065 ENOG4107VFR oxidoreductase CA592_04090 ENOG4105C1V Peptidase, M16 CA592_04095 ENOG4105CJ1 ABC, transporter CA592_04150 ENOG4105BZU Histidine kinase CA592_04160 ENOG4105K4I Scp-like extracellular CA592_04170 ENOG4107HP6 Transcriptional regulator CA592_04175 ENOG4105C82 Malate synthase CA592_04200 ENOG4105F0V Cell wall hydrolase CA592_04205 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CA592_04210 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CA592_04220 ENOG4107V6Q Cyclic nucleotide-binding domain CA592_04240 ENOG4105VG1 fes assembly suf system protein CA592_04250 ENOG4108M15 ABC transporter CA592_04270 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) CA592_04280 ENOG41090MY MarR family Transcriptional regulator CA592_04290 ENOG4105C2I pirin domain protein CA592_04315 ENOG4107QM2 Aldo Keto reductase CA592_04320 ENOG41090T1 Membrane CA592_04330 ENOG41082BM Transcriptional regulator, arsr family CA592_04340 ENOG4105K8R UPF0145 protein CA592_04345 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CA592_04355 ENOG4107QMH DNA methylase CA592_04360 ENOG4105C0D helicase CA592_04375 ENOG4105K8R UPF0145 protein CA592_04380 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CA592_04385 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CA592_04395 ENOG41069DP small acid-soluble spore protein CA592_04405 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CA592_04425 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CA592_04460 ENOG4105DWT malate dehydrogenase (quinone) CA592_04475 ENOG4107QQ0 gntp family CA592_04480 ENOG4105CK7 Sodium proline symporter CA592_04500 ENOG4105UIB (ABC) transporter CA592_04505 ENOG4108JQ9 ABC transporter CA592_04510 ENOG4105DIH basic membrane CA592_04515 ENOG4105FDP GntR family transcriptional regulator CA592_04520 ENOG4105CNU cell division protein FtsK CA592_04530 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CA592_04540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CA592_04550 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CA592_04555 ENOG4108S0H Dipicolinic acid synthetase, b subunit CA592_04560 ENOG4105E35 Dipicolinate synthase subunit A CA592_04570 ENOG4105C1V Peptidase, M16 CA592_04580 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CA592_04585 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CA592_04590 ENOG4105DTN riboflavin biosynthesis protein ribF CA592_04595 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CA592_04600 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CA592_04605 ENOG4105W7A Protein of unknown function (DUF503) CA592_04610 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CA592_04615 ENOG4105VHM ribosomal protein CA592_04620 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CA592_04625 ENOG4105CHV Transcription elongation factor NusA CA592_04630 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CA592_04635 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CA592_04640 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CA592_04645 ENOG4105DZP Membrane-associated zinc metalloprotease CA592_04650 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CA592_04655 ENOG4105KNE Phosphatidate cytidylyltransferase CA592_04660 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CA592_04665 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CA592_04670 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CA592_04675 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CA592_04680 ENOG4105CE9 30S ribosomal protein S2 CA592_04695 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CA592_04705 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) CA592_04715 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis CA592_04720 ENOG4105CBS Chea signal transduction histidine kinase CA592_04725 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CA592_04740 ENOG4105D7B Flagellar biosynthesis protein flha CA592_04750 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CA592_04755 ENOG4105VS8 Flagellar biosynthetic protein fliq CA592_04760 ENOG4105CN7 Flagellar biosynthetic protein FliP CA592_04770 ENOG4107YTP response regulator receiver protein CA592_04775 ENOG4105DD5 Flagellar motor switch protein CA592_04780 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CA592_04790 ENOG41068WV flagellar FlbD family protein CA592_04795 ENOG4108JQA flagellar CA592_04805 ENOG410822I Flagellar hook capping protein CA592_04815 ENOG4105D5G Transposase CA592_04835 ENOG4106YF4 Flagellar biosynthesis chaperone CA592_04850 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CA592_04860 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CA592_04865 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CA592_04870 ENOG4108ZC9 flagellar basal-body rod protein flgc CA592_04875 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CA592_04880 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) CA592_04885 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CA592_04890 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CA592_04895 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CA592_04900 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CA592_04905 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CA592_04910 ENOG4105C79 DNA protecting protein DprA CA592_04915 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CA592_04920 ENOG4105CMV Succinyl-CoA synthetase subunit beta CA592_04925 ENOG4105D00 flagellar biosynthetic protein flhB CA592_04930 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CA592_04935 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CA592_04945 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CA592_04950 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CA592_04955 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CA592_04965 ENOG4105VB6 UPF0109 protein CA592_04970 ENOG4105K5M 30s ribosomal protein S16 CA592_04980 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CA592_04985 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CA592_04990 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CA592_05000 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CA592_05005 ENOG4105CHR reductase CA592_05010 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CA592_05015 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CA592_05020 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CA592_05025 ENOG4105CB5 ATP-dependent DNA helicase recG CA592_05030 ENOG4105EJQ L-serine dehydratase CA592_05040 ENOG4105DP4 dak2 domain fusion protein ylov CA592_05045 ENOG4108ZAA Alkaline-shock protein CA592_05050 ENOG4105VB9 50S ribosomal protein l28 CA592_05060 ENOG4105FJ0 thiamine CA592_05065 ENOG4105DJV ribulose-phosphate 3-epimerase CA592_05070 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CA592_05075 ENOG4105D9P serine threonine protein kinase CA592_05080 ENOG4108ZF3 Phosphatase CA592_05085 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CA592_05090 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CA592_05095 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CA592_05100 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CA592_05105 ENOG4105C25 Primosomal protein n' CA592_05110 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CA592_05115 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CA592_05120 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CA592_05125 ENOG4105DSJ YicC domain protein CA592_05135 ENOG4105F23 Fibronectin-binding protein CA592_05190 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CA592_05195 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CA592_05200 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CA592_05215 ENOG4105CD3 dihydroorotase CA592_05220 ENOG4105CXT aspartate transcarbamylase CA592_05230 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CA592_05235 ENOG4105C34 Pseudouridine synthase CA592_05240 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CA592_05245 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CA592_05255 ENOG4105DBK s4 domain protein CA592_05260 ENOG41067XK integral membrane protein CA592_05265 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CA592_05270 ENOG4105DFA alanine racemase domain protein CA592_05275 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CA592_05280 ENOG4105WR5 sporulation protein, YlmC YmxH family CA592_05290 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CA592_05295 ENOG4108AWX Sporulation factor SpoIIGA CA592_05300 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CA592_05305 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CA592_05310 ENOG4105K67 small basic protein CA592_05320 ENOG4108R2U division initiation protein CA592_05325 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CA592_05330 ENOG4105D4A Cell wall formation (By similarity) CA592_05335 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CA592_05340 ENOG4105CNI cell division protein FtsW CA592_05345 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CA592_05350 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CA592_05355 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CA592_05360 ENOG4105CJN penicillin-binding protein CA592_05365 ENOG4105CJN penicillin-binding protein CA592_05370 ENOG41068DC Essential cell division protein (By similarity) CA592_05375 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CA592_05380 ENOG41074B2 UPF0747 protein CA592_05400 ENOG4105E39 Enoyl-CoA hydratase CA592_05405 ENOG41067VY 50S ribosomal protein L32 CA592_05410 ENOG4105KNH Nucleic acid-binding protein CA592_05415 ENOG4105CDE UPF0348 protein CA592_05420 ENOG41063PX domain protein CA592_05425 ENOG4105D78 K07001 NTE family protein CA592_05430 ENOG4105H20 Sporulation integral membrane protein YlbJ CA592_05435 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CA592_05440 ENOG4106H78 methyltransferase CA592_05455 ENOG4105WUC UPF0298 protein CA592_05480 ENOG4106UY4 Inherit from COG: Scp-like extracellular CA592_05530 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CA592_05535 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) CA592_05540 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CA592_05545 ENOG4105CNI cell division protein FtsW CA592_05550 ENOG4105ZPI UPF0358 protein CA592_05560 ENOG4108IAB Phoh family CA592_05585 ENOG4105QA2 CA592_05590 ENOG4105CI3 gtp-binding protein typa CA592_05600 ENOG4105ECY inositol monophosphatase CA592_05610 ENOG4105WBI UPF0223 protein CA592_05615 ENOG4105EA8 2-Nitropropane dioxygenase CA592_05620 ENOG4105CXN decarboxylase CA592_05670 ENOG4108X4Q Hydrolase CA592_05675 ENOG4106148 UPF0356 protein CA592_05680 ENOG4105CN5 Metallo-Beta-Lactamase CA592_05685 ENOG4107ZYR domain protein CA592_05690 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CA592_05695 ENOG4105CH2 amidohydrolase CA592_05700 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CA592_05710 ENOG4107IN1 Protein of unknown function (DUF1797) CA592_05720 ENOG4105EPM Diguanylate phosphodiesterase CA592_05725 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CA592_05740 ENOG4105WMR Protein CrcB homolog CA592_05745 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CA592_05750 ENOG4107R33 ppx gppa phosphatase CA592_05755 ENOG4105UIN CA592_05765 ENOG4108B31 Spore germination protein CA592_05795 ENOG4105BZU Histidine kinase CA592_05800 ENOG4107R88 Chemotaxis protein (CheV) CA592_05820 ENOG4105CHM Aminotransferase CA592_05825 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CA592_05830 ENOG4105CHR reductase CA592_05855 ENOG4105CID antiterminator CA592_05860 ENOG4105DQF Hydrolase CA592_05865 ENOG41068JE domain protein CA592_05870 ENOG4105KJM monovalent cation h antiporter subunit g CA592_05875 ENOG4105W4C monovalent cation H antiporter subunit F CA592_05880 ENOG4105SC1 monovalent cation H antiporter subunit E CA592_05885 ENOG4108JPZ Monovalent cation H antiporter subunit D CA592_05890 ENOG4108ZE9 Monovalent cation H antiporter subunit C CA592_05895 ENOG4105HC0 Na H antiporter CA592_05900 ENOG4105D65 subunit l CA592_05930 ENOG4105BZU Histidine kinase CA592_05960 ENOG4105K4T epimerase CA592_05965 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CA592_05970 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CA592_05975 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CA592_05980 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CA592_05985 ENOG4108UTW Plays a role in the regulation of phosphate uptake CA592_06000 ENOG4108K88 Membrane CA592_06015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CA592_06020 ENOG4105BZU Histidine kinase CA592_06045 ENOG4105D5Q Arginine ornithine antiporter CA592_06050 ENOG4105BZU Histidine kinase CA592_06065 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CA592_06070 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CA592_06075 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) CA592_06080 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate CA592_06090 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CA592_06095 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CA592_06100 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CA592_06105 ENOG4105BZU Histidine kinase CA592_06110 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) CA592_06115 ENOG4107QR9 Iron-sulfur cluster binding protein CA592_06120 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CA592_06125 ENOG4105JXH GntR family transcriptional regulator CA592_06155 ENOG4105CQB FAD linked oxidase domain protein CA592_06160 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CA592_06170 ENOG41090A1 ferritin CA592_06180 ENOG4107TS3 membrane protein, TerC CA592_06185 ENOG4105CUB amino acid CA592_06210 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CA592_06220 ENOG4108REF Sporulation integral membrane protein ytvi CA592_06225 ENOG4106M28 alanine racemase domain protein CA592_06250 ENOG4105HDK L-asparaginase CA592_06255 ENOG4108IMY Transcriptional regulator CA592_06260 ENOG4105G0J serine threonine protein kinase CA592_06275 ENOG4107T5V SNARE associated Golgi CA592_06280 ENOG4105CUB amino acid CA592_06335 ENOG4108YG4 CA592_06340 ENOG4105D5G Transposase CA592_06420 ENOG4105KTU Transcriptional regulator, arsr family CA592_06425 ENOG4105PGM cation diffusion facilitator family transporter CA592_06440 ENOG4105CE1 Ferrous iron transport protein b CA592_06445 ENOG4105CE1 Ferrous iron transport protein b CA592_06450 ENOG4105CE1 Ferrous iron transport protein b CA592_06460 ENOG4105DZR Type I site-specific deoxyribonuclease CA592_06475 ENOG4105CAQ asparagine synthetase CA592_06485 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) CA592_06585 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CA592_06600 ENOG4105C28 cystathionine CA592_06605 ENOG4105C28 cystathionine CA592_06610 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CA592_06620 ENOG4108ZMI UPF0477 protein CA592_06630 ENOG4105H67 Protein of unknown function (DUF421) CA592_06635 ENOG4105ENA helicase CA592_06655 ENOG4105SZ6 Thioredoxin CA592_06670 ENOG4105VZ8 Transcriptional regulator CA592_06675 ENOG4108QY0 Membrane CA592_06690 ENOG4105CZ3 stage V sporulation protein ad CA592_06695 ENOG41090VF Stage v sporulation protein ac CA592_06755 ENOG4105CJW magnesium transporter CA592_06765 ENOG4107S1Q Phosphatase CA592_06770 ENOG4105EMS pseudouridine synthase CA592_06775 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CA592_06785 ENOG4106EFP UPF0738 protein CA592_06790 ENOG4105MIX Adenylate cyclase CA592_06795 ENOG4105E4C Lytic transglycosylase catalytic CA592_06800 ENOG4108Z18 K06886 hemoglobin CA592_06805 ENOG4105T58 Dithiol-disulfide isomerase CA592_06810 ENOG4105DPN Oligoendopeptidase f CA592_06820 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis CA592_06825 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CA592_06830 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CA592_06840 ENOG4108JQ7 (ABC) transporter CA592_06850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CA592_06855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CA592_06870 ENOG4105C31 Tryptophanyl-tRNA synthetase CA592_06875 ENOG4108KU1 UPF0736 protein CA592_06890 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CA592_06895 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CA592_06900 ENOG4107RMD Basic membrane lipoprotein CA592_06915 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CA592_06925 ENOG4105DBV ornithine carbamoyltransferase CA592_06945 ENOG4105CAS nag kinase CA592_06950 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CA592_06955 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CA592_06960 ENOG4107V6Q Cyclic nucleotide-binding domain CA592_06970 ENOG4108MXZ Esterase CA592_06975 ENOG4108KP7 hydrolase CA592_06985 ENOG4107AYK membrAne CA592_06990 ENOG4105EPR degv family CA592_07000 ENOG4108VPT UPF0234 protein CA592_07015 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CA592_07020 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CA592_07025 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CA592_07030 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CA592_07035 ENOG4108P62 biosynthesis protein (CbiG) CA592_07040 ENOG4105CIA precorrin-4 C(11)-methyltransferase CA592_07050 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase CA592_07055 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CA592_07060 ENOG41081F0 Precorrin-8x methylmutase CA592_07065 ENOG4108JTQ reductase CA592_07070 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CA592_07075 ENOG4105E4R Precorrin-3B C17-methyltransferase CA592_07080 ENOG4108JJB ABC transporter CA592_07090 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CA592_07095 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CA592_07115 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CA592_07120 ENOG4105EG2 ABC transporter, permease CA592_07140 ENOG4107FKK extracellular solute-binding protein family 1 CA592_07150 ENOG4106HBX Transcriptional Regulator AraC Family CA592_07155 ENOG4105UQX Mate efflux family protein CA592_07160 ENOG4105CAQ asparagine synthetase CA592_07170 ENOG4105BZU Histidine kinase CA592_07185 ENOG4105YHS UPF0344 protein CA592_07205 ENOG4105C8Y Acetylornithine aminotransferase CA592_07210 ENOG4105ERH Fumarylacetoacetate hydrolase CA592_07260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CA592_07265 ENOG4108JQ7 (ABC) transporter CA592_07320 ENOG4105EYH Exonuclease CA592_07330 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CA592_07335 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination CA592_07345 ENOG4105XVF Competence transcription factor CA592_07355 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CA592_07360 ENOG4108ZX6 Electron transport protein SCO1 SenC CA592_07365 ENOG4105C8Q Methyl-accepting chemotaxis CA592_07375 ENOG4105D58 Diguanylate phosphodiesterase CA592_07385 ENOG4105C7J ABC transporter, permease CA592_07395 ENOG4105CEY Amp-dependent synthetase and ligase CA592_07410 ENOG4108RQ5 Beta-lactamase domain-containing protein CA592_07415 ENOG4106AXD CA592_07420 ENOG4105CG3 alpha amylase, catalytic region CA592_07430 ENOG4105ECB domain protein CA592_07440 ENOG4105C1Q protoporphyrinogen oxidase CA592_07445 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CA592_07450 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CA592_07455 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CA592_07475 ENOG4105K59 histidine triad (HIT) protein CA592_07480 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CA592_07500 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) CA592_07510 ENOG4105NBU tryptophan transport protein CA592_07515 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CA592_07530 ENOG4105D4P Coproporphyrinogen iii oxidase CA592_07540 ENOG4105WZB UPF0342 protein CA592_07545 ENOG4108UH6 UPF0754 membrane protein CA592_07570 ENOG4105YWU small acid-soluble spore protein CA592_07585 ENOG4105DWF phosphomethylpyrimidine kinase CA592_07590 ENOG4105D06 uba thif-type nad fad binding protein CA592_07600 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CA592_07605 ENOG41080HI glycine oxidase CA592_07610 ENOG4108VEU Thiamine monophosphate synthase CA592_07615 ENOG4108W7F transporter, permease CA592_07620 ENOG4108JJB ABC transporter CA592_07625 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CA592_07630 ENOG4105ETU transcriptional activator (TenA CA592_07650 ENOG41067TZ transcriptional regulator, MarR family CA592_07660 ENOG4105ED1 spovr family CA592_07665 ENOG4107QJR hflk protein CA592_07670 ENOG4105EPW hflc protein CA592_07675 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CA592_07695 ENOG41080XP Cbs domain CA592_07705 ENOG4105K63 Thioredoxin CA592_07715 ENOG4108YBP pseudouridine synthase CA592_07730 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CA592_07735 ENOG4107TPS domain protein CA592_07745 ENOG41087NI Sulfite exporter TauE/SafE CA592_07750 ENOG4105VFE sira family CA592_07755 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CA592_07760 ENOG4105VFE sira family CA592_07765 ENOG41085GJ domain protein CA592_07810 ENOG4106AKX UPF0229 protein CA592_07815 ENOG4105CYN Serine protein kinase CA592_07820 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CA592_07830 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CA592_07940 ENOG4105KT7 mgtC SapB transporter CA592_07950 ENOG4105C37 (CBS) domain CA592_07965 ENOG4106GRI small acid-soluble spore protein H CA592_07970 ENOG4107PBV potassium channel CA592_07985 ENOG4107QW4 alcohol dehydrogenase CA592_07990 ENOG4105WG9 Conserved Protein CA592_08005 ENOG4105CHM Aminotransferase CA592_08010 ENOG4108ZB6 transcriptional regulator AsnC family CA592_08015 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CA592_08040 ENOG41069ER domain protein CA592_08055 ENOG4105CEP NADH dehydrogenase CA592_08060 ENOG4105CAY ferredoxin--nadp reductase CA592_08065 ENOG41067VP Protein of unknown function (DUF1049) CA592_08070 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CA592_08075 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CA592_08105 ENOG41083MR nifu domain-containing protein CA592_08115 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CA592_08120 ENOG4105D6E homoserine dehydrogenase CA592_08125 ENOG4105C5I Dehydrogenase CA592_08135 ENOG4108W5N phosphatidylglycerophosphatase a CA592_08140 ENOG4105D4U had-superfamily hydrolase, subfamily iia CA592_08170 ENOG4105MMD transcriptional regulator CA592_08175 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CA592_08180 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CA592_08190 ENOG4105FAA peptidase M23 CA592_08195 ENOG4108YTE sporulation protein YunB CA592_08200 ENOG4105KZD Domain of unknown function (DUF1805) CA592_08205 ENOG4107R8B 5'-nucleotidase CA592_08215 ENOG4105I3N Conserved Protein CA592_08220 ENOG4105DIW FeS assembly protein SUFB CA592_08225 ENOG4108UNV SUF system FeS assembly protein, NifU family CA592_08235 ENOG4105JRK feS assembly protein SufD CA592_08240 ENOG4105C3K feS assembly ATPase SufC CA592_08250 ENOG4105D01 (LipO)protein CA592_08255 ENOG4108UMI ABC transporter, permease CA592_08260 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CA592_08305 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CA592_08310 ENOG41080E8 Transcriptional regulator, Spx MgsR family CA592_08320 ENOG4105C1G acyl-Coa dehydrogenase CA592_08325 ENOG4105CHU acetyl-coa acetyltransferase CA592_08370 ENOG4105XSJ toxin secretion phage lysis holin CA592_08475 ENOG410682Q Phage transcriptional regulator, ArpU CA592_08570 ENOG4108IMY Transcriptional regulator CA592_08580 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CA592_08595 ENOG410635T phage-like element pbsx protein CA592_08600 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CA592_08610 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CA592_08615 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CA592_08625 ENOG4105XZU Preprotein translocase, subunit SecG CA592_08645 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CA592_08650 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CA592_08655 ENOG4105CP7 Triose-phosphate isomerase CA592_08660 ENOG4105BZA Phosphoglycerate kinase CA592_08680 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CA592_08690 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CA592_08695 ENOG4105KRI phosphocarrier protein (HPr CA592_08700 ENOG4105CIE May be required for sporulation (By similarity) CA592_08705 ENOG4105CHW UPF0052 protein CA592_08710 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CA592_08715 ENOG4108Z4K mutator MutT protein CA592_08720 ENOG4105C3M thioredoxin reductase CA592_08730 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CA592_08735 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CA592_08740 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CA592_08745 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CA592_08750 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CA592_08755 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CA592_08760 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CA592_08765 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CA592_08770 ENOG4108S4C acetyltransferase CA592_08775 ENOG4107XGZ Hydrolase CA592_08780 ENOG4105HKU nucleoside recognition domain-containing protein CA592_08785 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CA592_08790 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CA592_08795 ENOG41086DT Membrane protein of unknown function CA592_08810 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CA592_08815 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CA592_08830 ENOG41062GF Polar chromosome segregation protein CA592_08835 ENOG4105CN1 protease CA592_08840 ENOG4105DR5 peptidase CA592_08845 ENOG4105CRP Part of the ABC transporter FtsEX involved in CA592_08850 ENOG4105CAK Cell division ATP-binding protein ftsE CA592_08890 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CA592_08905 ENOG4105CPI Metal Dependent Phosphohydrolase CA592_08915 ENOG41069ZS flagellar protein CA592_08920 ENOG4105MQ3 flagellar protein FliS CA592_08925 ENOG4107RT6 flagellar hook-associated CA592_08930 ENOG41083S7 flagellar protein FlaG CA592_08965 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CA592_08970 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) CA592_08980 ENOG4105DTJ flagellar hook-associated protein CA592_08985 ENOG4105E1Q flagellar hook-associated protein CA592_09000 ENOG4105RU3 CA592_09005 ENOG4105XVJ Protein of unknown function (DUF327) CA592_09025 ENOG4105I03 Flagellin CA592_09035 ENOG4105VM1 flagellar CA592_09045 ENOG41081UC Inherit from COG: Competence protein CA592_09060 ENOG4105WH1 Two component transcriptional regulator luxr family CA592_09065 ENOG4105BZU Histidine kinase CA592_09070 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CA592_09075 ENOG4108KGH TRANSCRIPTIONal CA592_09080 ENOG4105ESV Glycosyl transferase, family 4 CA592_09090 ENOG4105JFG SpoIID LytB domain protein CA592_09095 ENOG4107GBW cellulosome anchoring protein cohesin CA592_09105 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin CA592_09110 ENOG4105CGH 5'-nucleotidase CA592_09140 ENOG4105C0P Mg chelatase subunit ChlI CA592_09150 ENOG41067QW Transcriptional regulator CA592_09180 ENOG4105W5Q DNA repair protein (RadC CA592_09190 ENOG4105K4H Nlp p60 protein CA592_09200 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CA592_09225 ENOG4108IMY Transcriptional regulator CA592_09250 ENOG4105CFH Aspartokinase CA592_09260 ENOG4105XVF Competence transcription factor CA592_09290 ENOG4107GBW cellulosome anchoring protein cohesin CA592_09300 ENOG41060AI SEC-C motif CA592_09305 ENOG4105QNR S1 RNA binding domain protein CA592_09310 ENOG4105EE0 oxidoreductase CA592_09320 ENOG4107R3N Filamentation induced by cAMP protein fic CA592_09330 ENOG4105C0D helicase CA592_09335 ENOG4105CMR udp-glucose 4-epimerase CA592_09345 ENOG4105C6Y Udp-glucose 6-dehydrogenase CA592_09350 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein CA592_09410 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CA592_09415 ENOG41065RQ ADP-ribosylation crystallin J1 CA592_09435 ENOG4105EVU fructokinase CA592_09440 ENOG4105DG6 mannose-6-phosphate isomerase CA592_09445 ENOG4105DM4 PTS System CA592_09455 ENOG4105DM4 PTS System CA592_09460 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CA592_09475 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CA592_09485 ENOG4108TJN glycosyl transferase group 1 CA592_09515 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CA592_09525 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CA592_09530 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CA592_09550 ENOG4105D3Q Sugar transferase CA592_09555 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CA592_09565 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CA592_09570 ENOG4107YJ4 chain length determinant protein CA592_09575 ENOG4105HTX biosynthesis protein CA592_09590 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CA592_09615 ENOG4105CGA flagellar basal-body rod protein FlgG CA592_09625 ENOG4105DFF Rod shape-determining protein mreb CA592_09630 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CA592_09635 ENOG4105FRN stage II sporulation protein CA592_09645 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CA592_09655 ENOG4106778 Protein of unknown function (DUF1146) CA592_09660 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CA592_09665 ENOG4105C8S subunit m CA592_09670 ENOG4105D65 subunit l CA592_09675 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CA592_09685 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CA592_09690 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CA592_09695 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CA592_09700 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CA592_09705 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CA592_09710 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CA592_09715 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CA592_09720 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CA592_09725 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CA592_09730 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CA592_09735 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CA592_09740 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CA592_09745 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CA592_09750 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CA592_09765 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CA592_09770 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CA592_09775 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CA592_09780 ENOG4108UIC UPF0340 protein CA592_09785 ENOG4108YZG isomerase CA592_09790 ENOG4105C8Q Methyl-accepting chemotaxis CA592_09800 ENOG410815N Probably functions as a manganese efflux pump (By similarity) CA592_09805 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CA592_09810 ENOG4108ZXQ stage ii sporulation protein r CA592_09815 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CA592_09820 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CA592_09830 ENOG4105C26 Dehydrogenase CA592_09840 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CA592_09850 ENOG4105C0A alcohol dehydrogenase CA592_09855 ENOG4107104 thymidine kinase CA592_09860 ENOG41082DI 50s ribosomal protein l31 CA592_09865 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CA592_09870 ENOG4105CBT Fructose-1,6-bisphosphatase CA592_09875 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CA592_09880 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CA592_09890 ENOG410812K response regulator receiver protein CA592_09905 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CA592_09925 ENOG4105C1G acyl-Coa dehydrogenase CA592_09930 ENOG4105C1G acyl-Coa dehydrogenase CA592_09935 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CA592_09945 ENOG4105DF6 Fe-S oxidoreductase CA592_09955 ENOG4105C75 arginyL-tRNA synthetase CA592_09985 ENOG4105CYW agmatinase CA592_09995 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CA592_10000 ENOG4105BZ4 penicillin-binding protein CA592_10005 ENOG4108XFG YwhD family CA592_10010 ENOG4108Z4T Peptidase M50 CA592_10015 ENOG41069HH 4-oxalocrotonate tautomerase CA592_10025 ENOG4105DCI Phosphohydrolase CA592_10030 ENOG4105QAT UPF0741 protein CA592_10040 ENOG4108VCI transcription factor, rsfa family CA592_10045 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CA592_10050 ENOG4108IJ2 phosphate acetyltransferase CA592_10055 ENOG4108UM1 dedA family CA592_10060 ENOG4107JTW chlorite dismutase CA592_10065 ENOG4108VKI Cell wall hydrolase CA592_10105 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CA592_10110 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CA592_10115 ENOG4108JU3 Alkyl hydroperoxide reductase CA592_10125 ENOG4108RJ9 Glycosyl transferase, family 2 CA592_10130 ENOG41079KZ Major Facilitator Superfamily CA592_10135 ENOG4105KG3 cytidine deaminase CA592_10145 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CA592_10150 ENOG4107RHR regulatoR CA592_10160 ENOG4105D7K pfkb domain protein CA592_10165 ENOG4108K8K Transcriptional regulator CA592_10170 ENOG4105DCF alanine dehydrogenase CA592_10180 ENOG4105E5Q amino acid AbC transporter CA592_10185 ENOG4106PMH Extracellular solute-binding protein family 3 CA592_10190 ENOG4105C6N Formate acetyltransferase CA592_10195 ENOG4105F1A Pyruvate formate-lyase CA592_10200 ENOG4107URF beta-phospho-glucomutase CA592_10205 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase CA592_10210 ENOG4108Z66 YbaK ebsC protein CA592_10215 ENOG4108P49 AntiSigma factor CA592_10220 ENOG4105JVQ RNA Polymerase CA592_10270 ENOG4105BZU Histidine kinase CA592_10285 ENOG4108EKI Dehydrogenase CA592_10305 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CA592_10310 ENOG4105F38 ABC transporter, permease CA592_10315 ENOG4105D38 putrescine abc transporter CA592_10320 ENOG4107RUE extracellular solute-binding protein family 1 CA592_10325 ENOG4105DUX Transporter CA592_10330 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CA592_10340 ENOG4105C0H protease CA592_10345 ENOG4105Q2H domain protein CA592_10360 ENOG4105BZU Histidine kinase CA592_10365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CA592_10380 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CA592_10385 ENOG4105CDU Replicative dna helicase CA592_10390 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CA592_10395 ENOG4105BZR domain protein CA592_10400 ENOG4108XMW Membrane CA592_10405 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CA592_10410 ENOG4108UUM single-stranded DNA-binding protein CA592_10415 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CA592_10420 ENOG4105C3G gtp-binding protein CA592_10425 ENOG4105VDK protein, conserved in bacteria CA592_10430 ENOG4105D8X mechanosensitive ion channel CA592_10435 ENOG4108ZDA Sporulation protein YyaC CA592_10440 ENOG4108UQV Membrane CA592_10445 ENOG4105FA0 parb-like partition protein CA592_10450 ENOG4107QJE Chromosome Partitioning Protein CA592_10455 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) CA592_10460 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CA592_10465 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CA592_10470 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CA592_10475 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein CA592_10480 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CA592_10485 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CA592_10490 ENOG4105VG0 50S ribosomal protein l34 CA592_10495 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CA592_10500 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CA592_10505 ENOG410848D S4 domain protein YaaA CA592_10510 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CA592_10515 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CA592_10520 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CA592_10525 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CA592_10560 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CA592_10570 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CA592_10575 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CA592_10595 ENOG4105ZMH deoxynucleoside kinase CA592_10615 ENOG4108Z6B deaminase CA592_10625 ENOG4105C6E dna polymerase iii CA592_10630 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CA592_10635 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CA592_10645 ENOG41067KS pro-sigma K processing CA592_10680 ENOG4105CXN decarboxylase CA592_10685 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CA592_10690 ENOG4105FA2 dna polymerase iii CA592_10695 ENOG4105MA4 psp1 domain protein CA592_10700 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) CA592_10705 ENOG41060K3 Methyltransferase CA592_10710 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CA592_10715 ENOG4105KRN Transcriptional regulator, abrb family CA592_10725 ENOG4105F8V Hydrolase, tatD family CA592_10730 ENOG41069ER domain protein CA592_10735 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CA592_10740 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CA592_10745 ENOG4105XFA sporulation peptidase YabG CA592_10750 ENOG4105W42 Veg protein CA592_10755 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CA592_10760 ENOG4105DFT pur operon repressor CA592_10765 ENOG4105KME endoribonuclease L-psp CA592_10770 ENOG4105K4W Could be involved in septation (By similarity) CA592_10775 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CA592_10780 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CA592_10785 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CA592_10790 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CA592_10800 ENOG4108JA2 transcriptioN-repair coupling factor CA592_10805 ENOG4108M14 stage v sporulation protein t CA592_10815 ENOG4108IY2 MazG family CA592_10820 ENOG41082I2 s4 domain protein CA592_10825 ENOG4105VYY sporulation protein yabp CA592_10840 ENOG41060GV RNA binding s1 domain protein CA592_10870 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CA592_10875 ENOG4108UGV hypoxanthine phosphoribosyltransferase CA592_10880 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CA592_10885 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CA592_10895 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CA592_10900 ENOG4105C6T cysteine synthase CA592_10905 ENOG4105CRQ synthase (Component I) CA592_10910 ENOG4105DDQ anthranilate synthase CA592_10915 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CA592_10920 ENOG4105EEI dihydropteroate synthase CA592_10925 ENOG4105KRF dihydroneopterin aldolase CA592_10930 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CA592_10935 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CA592_10965 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CA592_11015 ENOG4108Z0C Uvrb UvrC protein CA592_11020 ENOG41066A3 ATP guanido phosphotransferase CA592_11030 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CA592_11035 ENOG4105CTP PilT protein domain protein CA592_11040 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CA592_11045 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CA592_11050 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CA592_11055 ENOG4105D7W serine acetyltransferase CA592_11060 ENOG4105C8N cysteinyl-tRNA synthetase CA592_11065 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CA592_11070 ENOG4105C2N RNA methyltransferase TrmH family group 3 CA592_11075 ENOG4105M0M Tetracycline resistance protein CA592_11080 ENOG4105QIV RNA polymerase CA592_11085 ENOG4107FTN 50S ribosomal protein L33 CA592_11095 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CA592_11100 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CA592_11105 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CA592_11110 ENOG4108VZM 50s ribosomal protein L10 CA592_11115 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CA592_11120 ENOG4107Y49 methyltransferase CA592_11125 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CA592_11130 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CA592_11135 ENOG4105XPM ribosomal protein CA592_11140 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CA592_11145 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CA592_11150 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CA592_11155 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CA592_11160 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CA592_11165 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CA592_11170 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CA592_11175 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CA592_11180 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CA592_11185 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CA592_11190 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CA592_11195 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CA592_11200 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CA592_11205 ENOG41082SA 50s ribosomal protein l29 CA592_11210 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CA592_11215 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CA592_11220 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CA592_11225 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CA592_11230 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CA592_11235 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CA592_11240 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CA592_11245 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CA592_11250 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CA592_11255 ENOG4105VPB 50S ribosomal protein L30 CA592_11260 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CA592_11265 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CA592_11270 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CA592_11275 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CA592_11280 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CA592_11285 ENOG41067V7 50S ribosomal protein L36 CA592_11290 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CA592_11295 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CA592_11300 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CA592_11305 ENOG4108ZT0 50S ribosomal protein l17 CA592_11310 ENOG4108JJB ABC transporter CA592_11315 ENOG4108JJB ABC transporter CA592_11320 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CA592_11325 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CA592_11330 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CA592_11335 ENOG4108UJD 30S ribosomal protein S9 CA592_11350 ENOG4105D1F ATP-binding protein CA592_11365 ENOG4108NMV polysaccharide deacetylase CA592_11445 ENOG4105EMN RNA polymerase sigma factor CA592_11455 ENOG4105C8B TIGR00159 family CA592_11460 ENOG4107U5W ybbr family CA592_11465 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CA592_11470 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CA592_11475 ENOG4107QMH DNA methylase CA592_11480 ENOG4105D5G Transposase CA592_11490 ENOG4108M15 ABC transporter CA592_11515 ENOG4105CAY ferredoxin--nadp reductase CA592_11570 ENOG4105CPF Cell wall formation (By similarity) CA592_11575 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CA592_11580 ENOG4105C1J atp-dependent rna helicase CA592_11585 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CA592_11590 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CA592_11595 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CA592_11610 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CA592_11625 ENOG410906U SprT-like CA592_11665 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CA592_11710 ENOG4105K8N protein family UPF0079, ATPase CA592_11715 ENOG41072GX Peptidase M22 Glycoprotease CA592_11720 ENOG410801F ribosomal-protein-alanine acetyltransferase CA592_11725 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CA592_11740 ENOG4105C5H ABC transporter CA592_11745 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CA592_11755 ENOG4108TYN CAAX amino terminal protease family protein CA592_11760 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CA592_11765 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CA592_11780 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CA592_11785 ENOG4105C7N Xanthine uracil vitamin C permease CA592_11810 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CA592_11815 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CA592_11820 ENOG4105C83 adenylosuccinate lyase CA592_11825 ENOG4105C8V SAICAR synthetase CA592_11830 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CA592_11835 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CA592_11840 ENOG4107QIK phosphoribosylformylglycinamidine synthase CA592_11850 ENOG4105CXB phosphoribosylaminoimidazole synthetase CA592_11855 ENOG4108V3E phosphoribosylglycinamide formyltransferase CA592_11860 ENOG4105DC1 bifunctional purine biosynthesis protein purh CA592_11865 ENOG4105C12 Phosphoribosylglycinamide synthetase CA592_11880 ENOG4108R5T secreted protein CA592_11885 ENOG4105KGF protein, YerC YecD CA592_11890 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) CA592_11905 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CA592_11915 ENOG4105C26 Dehydrogenase CA592_12000 ENOG4105CPN adenine deaminase CA592_12010 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CA592_12015 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CA592_12020 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CA592_12040 ENOG4105BZU Histidine kinase CA592_12060 ENOG4105DA5 (ABC) transporter CA592_12095 ENOG4105E2S oxidase) subunit II CA592_12190 ENOG4105EKQ RNA-directed DNA polymerase CA592_12205 ENOG4105DQ6 Transposase CA592_12230 ENOG4105CJ1 ABC, transporter CA592_12250 ENOG4105D5G Transposase CA592_12260 ENOG4105CK2 sodium dicarboxylate symporter CA592_12275 ENOG4107R6U sodium dicarboxylate symporter CA592_12280 ENOG4108AEY RNA polymerase sigma factor CA592_12285 ENOG4105J37 CA592_12325 ENOG41087YS Phage shock protein A CA592_12340 ENOG4105BZU Histidine kinase CA592_12345 ENOG4105XJC Two component transcriptional regulator (Winged helix family CA592_12350 ENOG4105CBD Diacylglycerol kinase CA592_12355 ENOG4105DU6 RNA polymerase CA592_12390 ENOG4105CVR type I restriction-modification system CA592_12395 ENOG4105EKX Restriction modification system DNA (Specificity CA592_12425 ENOG4105DAA L-lactate CA592_12450 ENOG4108ZCF integral membrane protein CA592_12490 ENOG41084AG Acylphosphatase CA592_12495 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CA592_12500 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CA592_12505 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CA592_12510 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CA592_12515 ENOG4107RIQ Sulfate adenylate transferase CA592_12525 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CA592_12540 ENOG41068PA UPF0435 protein CA592_12545 ENOG4105KJF protein tyrosine phosphatase CA592_12555 ENOG4107U9T Pfam:Ribonuclease_BN CA592_12565 ENOG4108ISG Major Facilitator CA592_12575 ENOG4105UPD Calcium Proton CA592_12645 ENOG4107QMH DNA methylase CA592_12685 ENOG4108JJ9 ABC, transporter CA592_12690 ENOG4105D5G Transposase CA592_12720 ENOG4105MZG transcriptional modulator of maze toxin, mazf CA592_12725 ENOG4106A2Z transcriptional regulator antitoxin, MazE CA592_12750 ENOG41086VY Fic/DOC family CA592_12780 ENOG4105CNG UPF0061 protein CA592_12810 ENOG4105ECP epimerase CA592_12820 ENOG410902V Modulates RecA activity (By similarity) CA592_12840 ENOG4105XHU Acid-soluble spore protein K CA592_12845 ENOG41067AE Membrane-bound metal-dependent hydrolase CA592_12855 ENOG4106BXE CA592_12865 ENOG4105EVI UPF0374 protein CA592_12870 ENOG4107NBY Membrane CA592_12875 ENOG4105CBC glutamate synthase CA592_12885 ENOG4108IUW ABC transporter CA592_12915 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CA592_12920 ENOG4105G5W regulator Fur family CA592_12925 ENOG4105TUA UPF0295 protein CA592_13005 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CA592_13085 ENOG4105PGM cation diffusion facilitator family transporter CA592_13095 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CA592_13105 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CA592_13120 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CA592_13125 ENOG4105E4F Isochorismate synthase CA592_13130 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CA592_13135 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CA592_13140 ENOG4108IPT Naphthoate synthase CA592_13145 ENOG4105CEY Amp-dependent synthetase and ligase CA592_13150 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CA592_13155 ENOG4105C4M (Ubiquinol oxidase) subunit I CA592_13185 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CA592_13190 ENOG4105NQC Flavodoxin CA592_13200 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CA592_13205 ENOG4105DSE periplasmic solute binding protein CA592_13210 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CA592_13215 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CA592_13220 ENOG4108RMU ferritin dps family protein CA592_13235 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CA592_13245 ENOG4105D2X ABC transporter substrate-binding protein CA592_13260 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CA592_13265 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CA592_13280 ENOG4108Z0R Transferase CA592_13285 ENOG4105E8V Alpha Beta Hydrolase Fold protein CA592_13305 ENOG4105N5T Radical SAM Protein CA592_13345 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CA592_13365 ENOG4105D8G Major Facilitator superfamily CA592_13375 ENOG4105C8T Leucyl-tRNA synthetase CA592_13380 ENOG41085GJ domain protein CA592_13385 ENOG4105CBX hi0933 family CA592_13405 ENOG4105YW5 deoR family transcriptional regulator CA592_13410 ENOG4107QSE Dipeptidase CA592_13430 ENOG41067MG lrgb family CA592_13440 ENOG4108IUM Glycogen debranching enzyme CA592_13445 ENOG4108V15 phosphotransferase enzyme family CA592_13455 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CA592_13475 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CA592_13485 ENOG4108NKM UPF0354 protein CA592_13490 ENOG4108VDD TRNA binding domain protein CA592_13505 ENOG4105DFU Cell wall formation (By similarity) CA592_13525 ENOG4105C88 aminopeptidase CA592_13530 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CA592_13535 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CA592_13540 ENOG4105ETE Transcriptional regulator (LacI family CA592_13545 ENOG4105DGU Histone deacetylase CA592_13550 ENOG4105W87 Cbs domain CA592_13555 ENOG4105F1V Acetoin utilization protein CA592_13575 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CA592_13590 ENOG4108W76 histidinol phosphate phosphatase hisj family CA592_13595 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) CA592_13610 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CA592_13680 ENOG4105CYW agmatinase CA592_13710 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CA592_13720 ENOG4105KBJ sporulation protein ytfj CA592_13725 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CA592_13735 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CA592_13745 ENOG4105CDH Citrulline--aspartate ligase CA592_13750 ENOG4105CH7 arginosuccinase CA592_13765 ENOG4107YZX Universal stress protein CA592_13775 ENOG4105DC7 peptidase M24 CA592_13785 ENOG4105E8R UPF0173 metal-dependent hydrolase CA592_13800 ENOG4105SFS phosphoesterase RecJ domain protein CA592_13810 ENOG4105VV2 CA592_13815 ENOG4105C0B DNA polymerase III (alpha subunit) CA592_13820 ENOG4105C6K Malic enzyme CA592_13835 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CA592_13840 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CA592_13845 ENOG4105CTQ phosphohexokinase CA592_13855 ENOG4105FS0 cytoplasmic membrane protein CA592_13860 ENOG4108REF Sporulation integral membrane protein ytvi CA592_13865 ENOG4108VMM UPF0756 membrane protein CA592_13875 ENOG4105BZN citrate synthase CA592_13880 ENOG4108HMX isocitrate dehydrogenase (NADP) CA592_13885 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CA592_13890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CA592_13895 ENOG4105BZU Histidine kinase CA592_13905 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CA592_13920 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CA592_13925 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CA592_13935 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CA592_13950 ENOG4108TDW sporulation protein YtxC CA592_13955 ENOG4105C22 threonyL-tRNA synthetase CA592_13965 ENOG4105VJV 50s ribosomal protein L35 CA592_13970 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CA592_13980 ENOG4105CN9 Peptidase m42 family protein CA592_13985 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CA592_13990 ENOG4105CMR udp-glucose 4-epimerase CA592_13995 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase CA592_14015 ENOG4105CNT hydrolase family 2 CA592_14035 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CA592_14040 ENOG41067MF small acid-soluble spore protein CA592_14045 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CA592_14050 ENOG4108RWN rrna methyltransferase CA592_14055 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CA592_14060 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CA592_14085 ENOG4108VB1 regulatoR CA592_14130 ENOG4105EYF MMPL domain protein CA592_14135 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CA592_14145 ENOG4105DCG PHP domain protein CA592_14150 ENOG4105C98 muts2 protein CA592_14165 ENOG4105CEY Amp-dependent synthetase and ligase CA592_14170 ENOG4107Z3H Transcriptional regulator, TetR family CA592_14175 ENOG41060WC Enoyl-CoA hydratase CA592_14180 ENOG4105BZJ Electron transfer flavoprotein CA592_14185 ENOG4105C10 Electron transfer flavoprotein CA592_14190 ENOG4105K63 Thioredoxin CA592_14220 ENOG4105CKK Glycosyl transferase, family 2 CA592_14245 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CA592_14255 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CA592_14265 ENOG4105E33 succinate dehydrogenase CA592_14275 ENOG4105PFC Transcriptional regulator CA592_14280 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CA592_14285 ENOG4108XJQ germination protein CA592_14290 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CA592_14295 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CA592_14300 ENOG4105M59 Phosphodiesterase, mj0936 family CA592_14310 ENOG4105CM2 brancheD-chain amino acid aminotransferase CA592_14315 ENOG4105C7K acetolactate synthase CA592_14320 ENOG4108ZP8 Acetolactate synthase small subunit CA592_14325 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CA592_14330 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CA592_14335 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CA592_14340 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CA592_14345 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CA592_14355 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CA592_14360 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CA592_14365 ENOG4108IUQ atp-dependent protease CA592_14375 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CA592_14385 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CA592_14395 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CA592_14405 ENOG4105D52 delta-aminolevulinic acid dehydratase CA592_14410 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CA592_14415 ENOG41068KH stage VI sporulation protein D CA592_14415 ENOG41068KH stage VI sporulation protein D CA592_14420 ENOG4106AR7 Spore coat protein CA592_14430 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CA592_14435 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CA592_14465 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CA592_14475 ENOG4107QHF type ii secretion system protein e CA592_14480 ENOG4105CZX twitching motility protein CA592_14495 ENOG4106A3R peptidase CA592_14530 ENOG4105W5Q DNA repair protein (RadC CA592_14535 ENOG4105DFF Rod shape-determining protein mreb CA592_14540 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CA592_14550 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CA592_14555 ENOG4107QMS site-determining protein CA592_14570 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CA592_14575 ENOG4105X36 (ribosomal) protein CA592_14580 ENOG4105K46 50S ribosomal protein l27 CA592_14590 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CA592_14595 ENOG41090I5 UPF0735 ACT domain-containing protein CA592_14600 ENOG4105CQC Prephenate dehydratase CA592_14615 ENOG4108IYU L-aspartate oxidase CA592_14620 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CA592_14625 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CA592_14630 ENOG4106678 morphogenetic protein associated with SpoVID CA592_14635 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CA592_14645 ENOG4105CDY transcriptional regulatory protein CA592_14655 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CA592_14660 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CA592_14665 ENOG41061AI Protein of unknown function (DUF2905) CA592_14670 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CA592_14675 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CA592_14680 ENOG4105VIE preprotein translocase, subunit YajC CA592_14690 ENOG4108QG2 Membrane CA592_14695 ENOG4105CKP Polysaccharide Biosynthesis Protein CA592_14705 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CA592_14715 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CA592_14720 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CA592_14725 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CA592_14730 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CA592_14735 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CA592_14740 ENOG4105CUT histidyl-tRNA synthetase CA592_14745 ENOG4105C9M aspartyl-trna synthetase CA592_14755 ENOG4105CUZ uba thif-type nad fad binding protein CA592_14765 ENOG41067SE Tetr family transcriptional regulator CA592_14770 ENOG4105D1H recombination factor protein RarA CA592_14780 ENOG4105C3J Cysteine desulfurase CA592_14785 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CA592_14795 ENOG4105C7H Helicase, RecD TraA family CA592_14800 ENOG41060CR CA592_14810 ENOG4105C02 permease CA592_14815 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CA592_14820 ENOG4105VBH UPF0297 protein CA592_14825 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CA592_14830 ENOG4105VPH UPF0473 protein CA592_14835 ENOG4105HHA aminodeoxychorismate lyase CA592_14840 ENOG4108VQJ O-methyltransferase CA592_14850 ENOG4105XYU peptidase (U32 family) CA592_14855 ENOG4105CFP Peptidase U32 CA592_14860 ENOG4105DBI uridine monophosphokinase CA592_14865 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CA592_14870 ENOG4107XRG penicillin-binding protein CA592_14885 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CA592_14890 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CA592_14905 ENOG4105C28 cystathionine CA592_14950 ENOG4108MES Periplasmic binding protein CA592_15015 ENOG4105PKS Excinuclease abc c subunit domain protein CA592_15060 ENOG4105E0A ABC, transporter CA592_15065 ENOG4108IHU transport system permease protein