locus-tag class description AF2641_00005 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AF2641_00040 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_00045 ENOG4105BZU Histidine kinase AF2641_00055 ENOG4105C7J ABC transporter, permease AF2641_00065 ENOG4105CEY Amp-dependent synthetase and ligase AF2641_00145 ENOG4105CNA YD repeat protein AF2641_00180 ENOG4107QN1 sodium solute AF2641_00195 ENOG4108RQ5 Beta-lactamase domain-containing protein AF2641_00200 ENOG4106AXD AF2641_00205 ENOG4105CG3 alpha amylase, catalytic region AF2641_00220 ENOG4107T3P ABC, transporter AF2641_00230 ENOG4105ECB domain protein AF2641_00240 ENOG4105C1Q protoporphyrinogen oxidase AF2641_00245 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AF2641_00250 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AF2641_00255 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AF2641_00260 ENOG41085GJ domain protein AF2641_00280 ENOG4105K59 histidine triad (HIT) protein AF2641_00285 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AF2641_00305 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) AF2641_00320 ENOG4105NBU tryptophan transport protein AF2641_00325 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AF2641_00340 ENOG4105D4P Coproporphyrinogen iii oxidase AF2641_00350 ENOG4105WZB UPF0342 protein AF2641_00355 ENOG4108UH6 UPF0754 membrane protein AF2641_00380 ENOG4105YWU small acid-soluble spore protein AF2641_00385 ENOG4105CDA abc transporter atp-binding protein AF2641_00390 ENOG4105DRP amino acid AbC transporter AF2641_00405 ENOG4105DWF phosphomethylpyrimidine kinase AF2641_00410 ENOG4105D06 uba thif-type nad fad binding protein AF2641_00415 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AF2641_00420 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AF2641_00425 ENOG41080HI glycine oxidase AF2641_00430 ENOG4108VEU Thiamine monophosphate synthase AF2641_00435 ENOG4108W7F transporter, permease AF2641_00440 ENOG4108JJB ABC transporter AF2641_00445 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein AF2641_00450 ENOG4105ETU transcriptional activator (TenA AF2641_00470 ENOG4105C0R drug resistance transporter emrb qaca subfamily AF2641_00475 ENOG41067TZ transcriptional regulator, MarR family AF2641_00480 ENOG4105ED1 spovr family AF2641_00485 ENOG4107QJR hflk protein AF2641_00490 ENOG4105EPW hflc protein AF2641_00495 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AF2641_00515 ENOG41080XP Cbs domain AF2641_00525 ENOG4105K63 Thioredoxin AF2641_00535 ENOG4108YBP pseudouridine synthase AF2641_00540 ENOG4105C37 (CBS) domain AF2641_00550 ENOG4107TPS domain protein AF2641_00560 ENOG41087NI Sulfite exporter TauE/SafE AF2641_00565 ENOG4105VFE sira family AF2641_00570 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AF2641_00575 ENOG4105VFE sira family AF2641_00580 ENOG41085GJ domain protein AF2641_00590 ENOG4105CYN Serine protein kinase AF2641_00595 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AF2641_00605 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AF2641_00620 ENOG4105ETE Transcriptional regulator (LacI family AF2641_00625 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AF2641_00635 ENOG4108JE9 extracellular solute-binding protein family 1 AF2641_00640 ENOG4105CS2 ec 3.2.1.21 AF2641_00745 ENOG4105TUA UPF0295 protein AF2641_00750 ENOG4105G5W regulator Fur family AF2641_00755 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AF2641_00770 ENOG4108IUW ABC transporter AF2641_00775 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AF2641_00780 ENOG4105CBC glutamate synthase AF2641_00785 ENOG4107NBY Membrane AF2641_00790 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AF2641_00795 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AF2641_00800 ENOG4105DEF Extracellular solute-binding protein, family 5 AF2641_00805 ENOG4108JQ7 (ABC) transporter AF2641_00810 ENOG4105C3U ABC transporter AF2641_00815 ENOG4105EVI UPF0374 protein AF2641_00825 ENOG4106BXE AF2641_00835 ENOG41067AE Membrane-bound metal-dependent hydrolase AF2641_00840 ENOG4105XHU Acid-soluble spore protein K AF2641_00855 ENOG4105DAA L-lactate AF2641_00860 ENOG4105EMU Dehydrogenase AF2641_00865 ENOG410902V Modulates RecA activity (By similarity) AF2641_00870 ENOG4105ECP epimerase AF2641_00895 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_00915 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AF2641_00925 ENOG410839P AF2641_00930 ENOG4105CNG UPF0061 protein AF2641_00940 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AF2641_00980 ENOG4105UPD Calcium Proton AF2641_00985 ENOG4108ISG Major Facilitator AF2641_00995 ENOG4107U9T Pfam:Ribonuclease_BN AF2641_01005 ENOG4105KJF protein tyrosine phosphatase AF2641_01010 ENOG41068PA UPF0435 protein AF2641_01020 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AF2641_01030 ENOG4107RIQ Sulfate adenylate transferase AF2641_01035 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AF2641_01040 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AF2641_01045 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AF2641_01050 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AF2641_01060 ENOG41084AG Acylphosphatase AF2641_01085 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AF2641_01090 ENOG4108ZCF integral membrane protein AF2641_01100 ENOG4105BZU Histidine kinase AF2641_01105 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_01145 ENOG4105BZU Histidine kinase AF2641_01165 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AF2641_01180 ENOG4107SDU Methyl-accepting chemotaxis AF2641_01190 ENOG4105E5W Transporter AF2641_01200 ENOG4105CBD Diacylglycerol kinase AF2641_01215 ENOG4105XJC Two component transcriptional regulator (Winged helix family AF2641_01220 ENOG4105BZU Histidine kinase AF2641_01230 ENOG41087YS Phage shock protein A AF2641_01240 ENOG4108ESY Metal dependent phosphohydrolase AF2641_01245 ENOG41060D1 Quinol oxidase AF2641_01260 ENOG4105E2S oxidase) subunit II AF2641_01265 ENOG4105C26 Dehydrogenase AF2641_01325 ENOG4108UMN azlc family AF2641_01345 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AF2641_01350 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AF2641_01355 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AF2641_01365 ENOG4105CPN adenine deaminase AF2641_01400 ENOG4105C26 Dehydrogenase AF2641_01410 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AF2641_01420 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) AF2641_01425 ENOG4105KGF protein, YerC YecD AF2641_01430 ENOG4108R5T secreted protein AF2641_01445 ENOG4105C12 Phosphoribosylglycinamide synthetase AF2641_01450 ENOG4105DC1 bifunctional purine biosynthesis protein purh AF2641_01455 ENOG4108V3E phosphoribosylglycinamide formyltransferase AF2641_01460 ENOG4105CXB phosphoribosylaminoimidazole synthetase AF2641_01475 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AF2641_01480 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AF2641_01485 ENOG4105C8V SAICAR synthetase AF2641_01490 ENOG4105C83 adenylosuccinate lyase AF2641_01495 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AF2641_01500 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AF2641_01505 ENOG4108ZNX Heat shock protein AF2641_01525 ENOG4105C7N Xanthine uracil vitamin C permease AF2641_01530 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AF2641_01540 ENOG4105CH7 arginosuccinase AF2641_01545 ENOG4107RDB Major Facilitator AF2641_01565 ENOG4105CYW agmatinase AF2641_01570 ENOG4107QNG Phosphoribosylglycinamide synthetase AF2641_01575 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AF2641_01580 ENOG4105TCH Asparagine synthase AF2641_01595 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AF2641_01600 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AF2641_01605 ENOG4108TYN CAAX amino terminal protease family protein AF2641_01615 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AF2641_01620 ENOG4105C5H ABC transporter AF2641_01630 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AF2641_01635 ENOG410801F ribosomal-protein-alanine acetyltransferase AF2641_01640 ENOG41072GX Peptidase M22 Glycoprotease AF2641_01645 ENOG4105K8N protein family UPF0079, ATPase AF2641_01690 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AF2641_01730 ENOG410906U SprT-like AF2641_01745 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AF2641_01755 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AF2641_01760 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AF2641_01765 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AF2641_01770 ENOG4105C1J atp-dependent rna helicase AF2641_01775 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AF2641_01780 ENOG4105CPF Cell wall formation (By similarity) AF2641_01810 ENOG4108ZJ4 polysaccharide deacetylase AF2641_01815 ENOG4107QX3 carboxylase AF2641_01820 ENOG4105E39 Enoyl-CoA hydratase AF2641_01825 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AF2641_01830 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AF2641_01835 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AF2641_01840 ENOG4105CEY Amp-dependent synthetase and ligase AF2641_01845 ENOG4105C1G acyl-Coa dehydrogenase AF2641_01865 ENOG4105CAY ferredoxin--nadp reductase AF2641_01870 ENOG4107TXC Transcriptional regulator AF2641_01875 ENOG4105WH1 Two component transcriptional regulator luxr family AF2641_01880 ENOG4105ENE Histidine kinase AF2641_01905 ENOG4106A2Z transcriptional regulator antitoxin, MazE AF2641_01940 ENOG4105F6E Acyl-transferase AF2641_01950 ENOG4105F22 Major Facilitator Superfamily AF2641_01955 ENOG4105CAQ asparagine synthetase AF2641_01965 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AF2641_02045 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AF2641_02050 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AF2641_02055 ENOG4107U5W ybbr family AF2641_02060 ENOG4105C8B TIGR00159 family AF2641_02070 ENOG4105EMN RNA polymerase sigma factor AF2641_02145 ENOG4108NMV polysaccharide deacetylase AF2641_02160 ENOG4105D1F ATP-binding protein AF2641_02175 ENOG4108UJD 30S ribosomal protein S9 AF2641_02180 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AF2641_02185 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AF2641_02190 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AF2641_02195 ENOG4108JJB ABC transporter AF2641_02200 ENOG4108JJB ABC transporter AF2641_02205 ENOG4108ZT0 50S ribosomal protein l17 AF2641_02210 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AF2641_02215 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AF2641_02220 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AF2641_02225 ENOG41067V7 50S ribosomal protein L36 AF2641_02230 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AF2641_02235 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AF2641_02240 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AF2641_02245 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AF2641_02250 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AF2641_02255 ENOG4105VPB 50S ribosomal protein L30 AF2641_02260 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AF2641_02265 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AF2641_02270 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AF2641_02275 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AF2641_02280 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AF2641_02285 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AF2641_02290 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AF2641_02295 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AF2641_02300 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AF2641_02305 ENOG41082SA 50s ribosomal protein l29 AF2641_02310 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AF2641_02315 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AF2641_02320 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AF2641_02325 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AF2641_02330 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AF2641_02335 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AF2641_02340 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AF2641_02345 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AF2641_02360 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AF2641_02365 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AF2641_02370 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AF2641_02375 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AF2641_02380 ENOG4105XPM ribosomal protein AF2641_02385 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AF2641_02390 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AF2641_02395 ENOG4107Y49 methyltransferase AF2641_02400 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AF2641_02405 ENOG4108VZM 50s ribosomal protein L10 AF2641_02410 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AF2641_02415 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AF2641_02420 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AF2641_02425 ENOG410683Z Preprotein translocase SecE subunit AF2641_02430 ENOG4107FTN 50S ribosomal protein L33 AF2641_02435 ENOG4105QIV RNA polymerase AF2641_02440 ENOG4105M0M Tetracycline resistance protein AF2641_02445 ENOG4105C2N RNA methyltransferase TrmH family group 3 AF2641_02450 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) AF2641_02455 ENOG4105C8N cysteinyl-tRNA synthetase AF2641_02460 ENOG4105D7W serine acetyltransferase AF2641_02465 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AF2641_02470 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AF2641_02475 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AF2641_02480 ENOG4105CTP PilT protein domain protein AF2641_02485 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AF2641_02495 ENOG41066A3 ATP guanido phosphotransferase AF2641_02500 ENOG4108Z0C Uvrb UvrC protein AF2641_02550 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AF2641_02580 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AF2641_02585 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AF2641_02590 ENOG4105KRF dihydroneopterin aldolase AF2641_02595 ENOG4105EEI dihydropteroate synthase AF2641_02600 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AF2641_02605 ENOG4105DDQ anthranilate synthase AF2641_02610 ENOG4105CRQ synthase (Component I) AF2641_02615 ENOG4105C6T cysteine synthase AF2641_02620 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AF2641_02625 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AF2641_02630 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AF2641_02635 ENOG4108UGV hypoxanthine phosphoribosyltransferase AF2641_02640 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AF2641_02670 ENOG41060GV RNA binding s1 domain protein AF2641_02685 ENOG4105VYY sporulation protein yabp AF2641_02690 ENOG41082I2 s4 domain protein AF2641_02695 ENOG4108IY2 MazG family AF2641_02705 ENOG4108M14 stage v sporulation protein t AF2641_02710 ENOG4108JA2 transcriptioN-repair coupling factor AF2641_02720 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AF2641_02725 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AF2641_02730 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AF2641_02735 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AF2641_02740 ENOG4105K4W Could be involved in septation (By similarity) AF2641_02745 ENOG4105KME endoribonuclease L-psp AF2641_02750 ENOG4105DFT pur operon repressor AF2641_02755 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AF2641_02760 ENOG4105W42 Veg protein AF2641_02765 ENOG4105XFA sporulation peptidase YabG AF2641_02770 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AF2641_02775 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AF2641_02795 ENOG4105F8V Hydrolase, tatD family AF2641_02805 ENOG4105KRN Transcriptional regulator, abrb family AF2641_02810 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AF2641_02815 ENOG41060K3 Methyltransferase AF2641_02820 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) AF2641_02825 ENOG4105MA4 psp1 domain protein AF2641_02830 ENOG4105FA2 dna polymerase iii AF2641_02835 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AF2641_02840 ENOG4105CXN decarboxylase AF2641_02875 ENOG41067KS pro-sigma K processing AF2641_02885 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AF2641_02890 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AF2641_02895 ENOG4105C6E dna polymerase iii AF2641_02905 ENOG4108Z6B deaminase AF2641_02915 ENOG4105ZMH deoxynucleoside kinase AF2641_02925 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AF2641_02930 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AF2641_02935 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AF2641_02945 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AF2641_02980 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AF2641_02985 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AF2641_02990 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AF2641_02995 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AF2641_03000 ENOG410848D S4 domain protein YaaA AF2641_03005 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AF2641_03010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AF2641_03015 ENOG4105VG0 50S ribosomal protein l34 AF2641_03020 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AF2641_03025 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AF2641_03030 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein AF2641_03035 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AF2641_03040 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AF2641_03045 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AF2641_03050 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) AF2641_03055 ENOG4107QJE Chromosome Partitioning Protein AF2641_03060 ENOG4105FA0 parb-like partition protein AF2641_03065 ENOG4108UQV Membrane AF2641_03075 ENOG4105D8X mechanosensitive ion channel AF2641_03080 ENOG4105VDK protein, conserved in bacteria AF2641_03085 ENOG4105C3G gtp-binding protein AF2641_03090 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AF2641_03095 ENOG4108UUM single-stranded DNA-binding protein AF2641_03100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AF2641_03105 ENOG4108XMW Membrane AF2641_03110 ENOG4105BZR domain protein AF2641_03115 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AF2641_03120 ENOG4105CDU Replicative dna helicase AF2641_03125 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AF2641_03140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AF2641_03145 ENOG4105BZU Histidine kinase AF2641_03160 ENOG4105Q2H domain protein AF2641_03165 ENOG4105C0H protease AF2641_03175 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AF2641_03180 ENOG4105DUX Transporter AF2641_03185 ENOG4107RUE extracellular solute-binding protein family 1 AF2641_03190 ENOG4105D38 putrescine abc transporter AF2641_03195 ENOG4105F38 ABC transporter, permease AF2641_03200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AF2641_03210 ENOG4108Q8B Spore germination protein AF2641_03215 ENOG4105E1K spore germination protein AF2641_03235 ENOG4108EKI Dehydrogenase AF2641_03245 ENOG4108Z66 YbaK ebsC protein AF2641_03250 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AF2641_03255 ENOG4107URF beta-phospho-glucomutase AF2641_03260 ENOG4105F1A Pyruvate formate-lyase AF2641_03270 ENOG4106PMH Extracellular solute-binding protein family 3 AF2641_03275 ENOG4105E5Q amino acid AbC transporter AF2641_03285 ENOG4105DCF alanine dehydrogenase AF2641_03290 ENOG4108K8K Transcriptional regulator AF2641_03295 ENOG4105D7K pfkb domain protein AF2641_03300 ENOG4107RHR regulatoR AF2641_03310 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AF2641_03320 ENOG4105KG3 cytidine deaminase AF2641_03330 ENOG4105D7V transposase AF2641_03335 ENOG41079KZ Major Facilitator Superfamily AF2641_03340 ENOG4108RJ9 Glycosyl transferase, family 2 AF2641_03355 ENOG4108JU3 Alkyl hydroperoxide reductase AF2641_03360 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AF2641_03365 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AF2641_03375 ENOG4105CKD glutathione-regulated potassium-efflux system protein AF2641_03380 ENOG4105CG3 alpha amylase, catalytic region AF2641_03400 ENOG4108VKI Cell wall hydrolase AF2641_03405 ENOG4107JTW chlorite dismutase AF2641_03410 ENOG4108UM1 dedA family AF2641_03415 ENOG4108IJ2 phosphate acetyltransferase AF2641_03420 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AF2641_03425 ENOG4108VCI transcription factor, rsfa family AF2641_03430 ENOG4105QAT UPF0741 protein AF2641_03435 ENOG4105DCI Phosphohydrolase AF2641_03445 ENOG41069HH 4-oxalocrotonate tautomerase AF2641_03450 ENOG4108Z4T Peptidase M50 AF2641_03455 ENOG4108XFG YwhD family AF2641_03460 ENOG4105BZ4 penicillin-binding protein AF2641_03465 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AF2641_03470 ENOG4105CYW agmatinase AF2641_03485 ENOG4105C75 arginyL-tRNA synthetase AF2641_03495 ENOG4105DF6 Fe-S oxidoreductase AF2641_03505 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AF2641_03510 ENOG4105C1G acyl-Coa dehydrogenase AF2641_03515 ENOG4105C1G acyl-Coa dehydrogenase AF2641_03525 ENOG4105D5P Methylmalonyl-coA mutase AF2641_03535 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AF2641_03545 ENOG410812K response regulator receiver protein AF2641_03555 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AF2641_03560 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AF2641_03565 ENOG4105CBT Fructose-1,6-bisphosphatase AF2641_03570 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AF2641_03575 ENOG41082DI 50s ribosomal protein l31 AF2641_03580 ENOG4107104 thymidine kinase AF2641_03585 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AF2641_03590 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AF2641_03595 ENOG4108ZXQ stage ii sporulation protein r AF2641_03600 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AF2641_03605 ENOG410815N Probably functions as a manganese efflux pump (By similarity) AF2641_03615 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_03620 ENOG4108YZG isomerase AF2641_03625 ENOG4108UIC UPF0340 protein AF2641_03630 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AF2641_03635 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AF2641_03640 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AF2641_03655 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AF2641_03660 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AF2641_03665 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AF2641_03670 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AF2641_03675 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AF2641_03680 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AF2641_03685 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AF2641_03690 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AF2641_03695 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AF2641_03700 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AF2641_03705 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AF2641_03710 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AF2641_03715 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AF2641_03720 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AF2641_03730 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AF2641_03735 ENOG4105D65 subunit l AF2641_03740 ENOG4105C8S subunit m AF2641_03745 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AF2641_03750 ENOG4106778 Protein of unknown function (DUF1146) AF2641_03760 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AF2641_03770 ENOG4105FRN stage II sporulation protein AF2641_03775 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AF2641_03780 ENOG4105DFF Rod shape-determining protein mreb AF2641_03785 ENOG4105D7V transposase AF2641_03795 ENOG4105CGA flagellar basal-body rod protein FlgG AF2641_03805 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AF2641_03820 ENOG4105HTX biosynthesis protein AF2641_03825 ENOG4107YJ4 chain length determinant protein AF2641_03830 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AF2641_03840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AF2641_03845 ENOG4105D3Q Sugar transferase AF2641_03850 ENOG4105C30 Nad-dependent epimerase dehydratase AF2641_03855 ENOG4105C0K Gdp-mannose 4,6-dehydratase AF2641_03865 ENOG4105K64 Glycosyl transferase, family 2 AF2641_03880 ENOG4105K64 Glycosyl transferase, family 2 AF2641_03885 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB AF2641_03900 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) AF2641_03920 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AF2641_03930 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AF2641_03950 ENOG4105DG6 mannose-6-phosphate isomerase AF2641_03955 ENOG4105EVU fructokinase AF2641_03990 ENOG4105C6Y Udp-glucose 6-dehydrogenase AF2641_03995 ENOG4105CMR udp-glucose 4-epimerase AF2641_04005 ENOG4105C0D helicase AF2641_04015 ENOG4107R3N Filamentation induced by cAMP protein fic AF2641_04030 ENOG4105EE0 oxidoreductase AF2641_04035 ENOG4105QNR S1 RNA binding domain protein AF2641_04040 ENOG41060AI SEC-C motif AF2641_04050 ENOG4107GBW cellulosome anchoring protein cohesin AF2641_04080 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_04085 ENOG4105XVF Competence transcription factor AF2641_04095 ENOG4105CFH Aspartokinase AF2641_04120 ENOG4108IMY Transcriptional regulator AF2641_04140 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AF2641_04150 ENOG4105K4H Nlp p60 protein AF2641_04190 ENOG4105CGH 5'-nucleotidase AF2641_04195 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin AF2641_04205 ENOG4108SHJ s-layer protein AF2641_04210 ENOG4105JFG SpoIID LytB domain protein AF2641_04220 ENOG4105ESV Glycosyl transferase, family 4 AF2641_04225 ENOG4108KGH TRANSCRIPTIONal AF2641_04230 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AF2641_04235 ENOG4105BZU Histidine kinase AF2641_04240 ENOG4105WH1 Two component transcriptional regulator luxr family AF2641_04260 ENOG41081UC Inherit from COG: Competence protein AF2641_04270 ENOG4105VM1 flagellar AF2641_04285 ENOG4105XVJ Protein of unknown function (DUF327) AF2641_04290 ENOG4105RU3 AF2641_04305 ENOG4105E1Q flagellar hook-associated protein AF2641_04310 ENOG4105DTJ flagellar hook-associated protein AF2641_04320 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AF2641_04325 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AF2641_04340 ENOG4105I03 Flagellin AF2641_04345 ENOG41083S7 flagellar protein FlaG AF2641_04350 ENOG4107RT6 flagellar hook-associated AF2641_04355 ENOG4105MQ3 flagellar protein FliS AF2641_04360 ENOG41069ZS flagellar protein AF2641_04370 ENOG4105CPI Metal Dependent Phosphohydrolase AF2641_04385 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AF2641_04390 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AF2641_04405 ENOG4105CAK Cell division ATP-binding protein ftsE AF2641_04410 ENOG4105CRP Part of the ABC transporter FtsEX involved in AF2641_04415 ENOG4105DR5 peptidase AF2641_04420 ENOG4105CN1 protease AF2641_04425 ENOG41062GF Polar chromosome segregation protein AF2641_04440 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AF2641_04445 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AF2641_04460 ENOG41086DT Membrane protein of unknown function AF2641_04470 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AF2641_04475 ENOG4105HKU nucleoside recognition domain-containing protein AF2641_04480 ENOG4107XGZ Hydrolase AF2641_04485 ENOG4108S4C acetyltransferase AF2641_04490 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AF2641_04495 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AF2641_04505 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AF2641_04510 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AF2641_04515 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AF2641_04520 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AF2641_04525 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AF2641_04535 ENOG4105C3M thioredoxin reductase AF2641_04540 ENOG4108Z4K mutator MutT protein AF2641_04545 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AF2641_04550 ENOG4105CHW UPF0052 protein AF2641_04555 ENOG4105CIE May be required for sporulation (By similarity) AF2641_04560 ENOG4105KRI phosphocarrier protein (HPr AF2641_04565 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AF2641_04575 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AF2641_04595 ENOG4105BZA Phosphoglycerate kinase AF2641_04600 ENOG4105CP7 Triose-phosphate isomerase AF2641_04605 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AF2641_04610 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AF2641_04725 ENOG4105XZU Preprotein translocase, subunit SecG AF2641_04735 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AF2641_04740 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AF2641_04785 ENOG4105CHU acetyl-coa acetyltransferase AF2641_04790 ENOG4105C1G acyl-Coa dehydrogenase AF2641_04795 ENOG41080E8 Transcriptional regulator, Spx MgsR family AF2641_04800 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AF2641_04840 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AF2641_04845 ENOG4108UMI ABC transporter, permease AF2641_04850 ENOG4105D01 (LipO)protein AF2641_04860 ENOG4105C3K feS assembly ATPase SufC AF2641_04865 ENOG4105JRK feS assembly protein SufD AF2641_04875 ENOG4108UNV SUF system FeS assembly protein, NifU family AF2641_04880 ENOG4105DIW FeS assembly protein SUFB AF2641_04940 ENOG4105EKQ RNA-directed DNA polymerase AF2641_04960 ENOG4105D5G Transposase AF2641_04965 ENOG4105C31 Tryptophanyl-tRNA synthetase AF2641_05000 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AF2641_05030 ENOG4105DA5 (ABC) transporter AF2641_05040 ENOG4105I3N Conserved Protein AF2641_05050 ENOG4107R8B 5'-nucleotidase AF2641_05055 ENOG4105KZD Domain of unknown function (DUF1805) AF2641_05060 ENOG4108YTE sporulation protein YunB AF2641_05065 ENOG4105C8J )-transporter AF2641_05075 ENOG4105FAA peptidase M23 AF2641_05080 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AF2641_05085 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AF2641_05090 ENOG4105MMD transcriptional regulator AF2641_05115 ENOG4105D4U had-superfamily hydrolase, subfamily iia AF2641_05120 ENOG4108W5N phosphatidylglycerophosphatase a AF2641_05130 ENOG4105C5I Dehydrogenase AF2641_05135 ENOG4105D6E homoserine dehydrogenase AF2641_05140 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AF2641_05145 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AF2641_05150 ENOG41083MR nifu domain-containing protein AF2641_05175 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AF2641_05180 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AF2641_05185 ENOG41067VP Protein of unknown function (DUF1049) AF2641_05190 ENOG4105CAY ferredoxin--nadp reductase AF2641_05195 ENOG4105CEP NADH dehydrogenase AF2641_05205 ENOG41069ER domain protein AF2641_05235 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AF2641_05240 ENOG4108ZB6 transcriptional regulator AsnC family AF2641_05245 ENOG4105CHM Aminotransferase AF2641_05260 ENOG4105WG9 Conserved Protein AF2641_05265 ENOG4107QW4 alcohol dehydrogenase AF2641_05280 ENOG4107PBV potassium channel AF2641_05285 ENOG4106GRI small acid-soluble spore protein H AF2641_05340 ENOG4108JJA ABC, transporter AF2641_05395 ENOG4105CJ1 ABC, transporter AF2641_05430 ENOG4105C37 (CBS) domain AF2641_05435 ENOG41082YX Transcriptional regulator, arsr family AF2641_05445 ENOG4105KT7 mgtC SapB transporter AF2641_05500 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AF2641_05580 ENOG4105PGM cation diffusion facilitator family transporter AF2641_05590 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AF2641_05600 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AF2641_05615 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AF2641_05620 ENOG4105E4F Isochorismate synthase AF2641_05625 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AF2641_05630 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AF2641_05635 ENOG4108IPT Naphthoate synthase AF2641_05640 ENOG4105CEY Amp-dependent synthetase and ligase AF2641_05645 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AF2641_05650 ENOG4105C4M (Ubiquinol oxidase) subunit I AF2641_05670 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AF2641_05675 ENOG4105NQC Flavodoxin AF2641_05680 ENOG4105D7V transposase AF2641_05685 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AF2641_05700 ENOG4105DSE periplasmic solute binding protein AF2641_05705 ENOG4105CKI cobalamin synthesis protein AF2641_05710 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AF2641_05715 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) AF2641_05725 ENOG4108RMU ferritin dps family protein AF2641_05740 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AF2641_05750 ENOG4105D2X ABC transporter substrate-binding protein AF2641_05765 ENOG4108JJB ABC transporter AF2641_05770 ENOG4108V4M Cobalt abc transporter AF2641_05790 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AF2641_05795 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AF2641_05800 ENOG4108Z0R Transferase AF2641_05805 ENOG4105E8V Alpha Beta Hydrolase Fold protein AF2641_05825 ENOG4105N5T Radical SAM Protein AF2641_05840 ENOG4105C8T Leucyl-tRNA synthetase AF2641_05845 ENOG41085GJ domain protein AF2641_05850 ENOG4105CBX hi0933 family AF2641_05870 ENOG4105YW5 deoR family transcriptional regulator AF2641_05875 ENOG4107QSE Dipeptidase AF2641_05890 ENOG4105VAW lrga family AF2641_05895 ENOG41067MG lrgb family AF2641_05905 ENOG4108IUM Glycogen debranching enzyme AF2641_05910 ENOG4108V15 phosphotransferase enzyme family AF2641_05920 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AF2641_05925 ENOG4105C8F Beta-lactamase domain protein AF2641_05940 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AF2641_05950 ENOG4108NKM UPF0354 protein AF2641_05955 ENOG4108VDD TRNA binding domain protein AF2641_05970 ENOG4105DFU Cell wall formation (By similarity) AF2641_05990 ENOG4105C88 aminopeptidase AF2641_05995 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AF2641_06000 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AF2641_06005 ENOG4105ETE Transcriptional regulator (LacI family AF2641_06020 ENOG4105W87 Cbs domain AF2641_06025 ENOG4105F1V Acetoin utilization protein AF2641_06045 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AF2641_06050 ENOG4105BZU Histidine kinase AF2641_06060 ENOG4108W76 histidinol phosphate phosphatase hisj family AF2641_06065 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) AF2641_06080 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AF2641_06090 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AF2641_06095 ENOG4105C0Z ABC transporter AF2641_06105 ENOG4105C32 Amino acid ABC transporter (Permease) AF2641_06115 ENOG4105CP9 extracellular ligand-binding receptor AF2641_06120 ENOG4108IV0 ABC, transporter AF2641_06130 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AF2641_06140 ENOG4105KBJ sporulation protein ytfj AF2641_06145 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AF2641_06155 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AF2641_06165 ENOG4105CDH Citrulline--aspartate ligase AF2641_06170 ENOG4105CH7 arginosuccinase AF2641_06185 ENOG4105DC7 peptidase M24 AF2641_06190 ENOG4105E8R UPF0173 metal-dependent hydrolase AF2641_06205 ENOG4105SFS phosphoesterase RecJ domain protein AF2641_06215 ENOG4105VV2 AF2641_06220 ENOG4105C0B DNA polymerase III (alpha subunit) AF2641_06225 ENOG4105C6K Malic enzyme AF2641_06235 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AF2641_06240 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AF2641_06245 ENOG4105CTQ phosphohexokinase AF2641_06255 ENOG4105FS0 cytoplasmic membrane protein AF2641_06260 ENOG4108REF Sporulation integral membrane protein ytvi AF2641_06265 ENOG4108VMM UPF0756 membrane protein AF2641_06270 ENOG4105BZN citrate synthase AF2641_06275 ENOG4108HMX isocitrate dehydrogenase (NADP) AF2641_06280 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AF2641_06290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AF2641_06295 ENOG4105BZU Histidine kinase AF2641_06305 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AF2641_06320 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AF2641_06325 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AF2641_06335 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AF2641_06350 ENOG4108TDW sporulation protein YtxC AF2641_06355 ENOG4105C22 threonyL-tRNA synthetase AF2641_06365 ENOG4105VJV 50s ribosomal protein L35 AF2641_06370 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AF2641_06380 ENOG4105CN9 Peptidase m42 family protein AF2641_06405 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AF2641_06410 ENOG4105CMR udp-glucose 4-epimerase AF2641_06415 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase AF2641_06430 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AF2641_06435 ENOG41067MF small acid-soluble spore protein AF2641_06440 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AF2641_06445 ENOG4108RWN rrna methyltransferase AF2641_06450 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AF2641_06455 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AF2641_06520 ENOG4105BZU Histidine kinase AF2641_06525 ENOG4105WH1 Two component transcriptional regulator luxr family AF2641_06560 ENOG4105BZ1 (ABC) transporter AF2641_06610 ENOG4105EYF MMPL domain protein AF2641_06625 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AF2641_06635 ENOG4105DCG PHP domain protein AF2641_06640 ENOG4105C98 muts2 protein AF2641_06650 ENOG4105CEY Amp-dependent synthetase and ligase AF2641_06655 ENOG4107Z3H Transcriptional regulator, TetR family AF2641_06660 ENOG41060WC Enoyl-CoA hydratase AF2641_06665 ENOG4105BZJ Electron transfer flavoprotein AF2641_06670 ENOG4105C10 Electron transfer flavoprotein AF2641_06675 ENOG4105K63 Thioredoxin AF2641_06720 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AF2641_06730 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AF2641_06740 ENOG4105E33 succinate dehydrogenase AF2641_06750 ENOG4105PFC Transcriptional regulator AF2641_06755 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AF2641_06760 ENOG4108XJQ germination protein AF2641_06765 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AF2641_06770 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AF2641_06775 ENOG4105M59 Phosphodiesterase, mj0936 family AF2641_06785 ENOG4105CM2 brancheD-chain amino acid aminotransferase AF2641_06790 ENOG4105C7K acetolactate synthase AF2641_06795 ENOG4108ZP8 Acetolactate synthase small subunit AF2641_06800 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AF2641_06805 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AF2641_06810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AF2641_06815 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AF2641_06820 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AF2641_06830 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AF2641_06835 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AF2641_06840 ENOG4108IUQ atp-dependent protease AF2641_06850 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AF2641_06860 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AF2641_06870 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AF2641_06880 ENOG4105D52 delta-aminolevulinic acid dehydratase AF2641_06885 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AF2641_06890 ENOG41068KH stage VI sporulation protein D AF2641_06890 ENOG41068KH stage VI sporulation protein D AF2641_06895 ENOG4106AR7 Spore coat protein AF2641_06905 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AF2641_06910 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AF2641_06955 ENOG4107QHF type ii secretion system protein e AF2641_06960 ENOG4105CZX twitching motility protein AF2641_06975 ENOG4106A3R peptidase AF2641_07010 ENOG4105W5Q DNA repair protein (RadC AF2641_07015 ENOG4105DFF Rod shape-determining protein mreb AF2641_07020 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AF2641_07030 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AF2641_07035 ENOG4107QMS site-determining protein AF2641_07050 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AF2641_07055 ENOG4105X36 (ribosomal) protein AF2641_07060 ENOG4105K46 50S ribosomal protein l27 AF2641_07070 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AF2641_07075 ENOG41090I5 UPF0735 ACT domain-containing protein AF2641_07080 ENOG4105CQC Prephenate dehydratase AF2641_07095 ENOG4108IYU L-aspartate oxidase AF2641_07100 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AF2641_07105 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AF2641_07110 ENOG4106678 morphogenetic protein associated with SpoVID AF2641_07115 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AF2641_07125 ENOG4105CDY transcriptional regulatory protein AF2641_07135 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AF2641_07140 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AF2641_07145 ENOG4105D7V transposase AF2641_07150 ENOG41061AI Protein of unknown function (DUF2905) AF2641_07155 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AF2641_07160 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AF2641_07165 ENOG4105VIE preprotein translocase, subunit YajC AF2641_07170 ENOG4105NAP AF2641_07175 ENOG4108QG2 Membrane AF2641_07180 ENOG4105CKP Polysaccharide Biosynthesis Protein AF2641_07190 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AF2641_07195 ENOG41076HS cation diffusion facilitator family transporter AF2641_07200 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AF2641_07205 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AF2641_07210 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AF2641_07215 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AF2641_07220 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AF2641_07225 ENOG4105CUT histidyl-tRNA synthetase AF2641_07230 ENOG4105C9M aspartyl-trna synthetase AF2641_07240 ENOG4105CUZ uba thif-type nad fad binding protein AF2641_07250 ENOG41067SE Tetr family transcriptional regulator AF2641_07255 ENOG4105D1H recombination factor protein RarA AF2641_07265 ENOG4105C3J Cysteine desulfurase AF2641_07270 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AF2641_07290 ENOG41060CR AF2641_07300 ENOG4105C02 permease AF2641_07305 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AF2641_07310 ENOG4105VBH UPF0297 protein AF2641_07315 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AF2641_07320 ENOG4105VPH UPF0473 protein AF2641_07325 ENOG4105HHA aminodeoxychorismate lyase AF2641_07335 ENOG4105XYU peptidase (U32 family) AF2641_07340 ENOG4105CFP Peptidase U32 AF2641_07345 ENOG4105DBI uridine monophosphokinase AF2641_07350 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AF2641_07355 ENOG4107XRG penicillin-binding protein AF2641_07370 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AF2641_07375 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AF2641_07385 ENOG4105C28 cystathionine AF2641_07435 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) AF2641_07445 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AF2641_07450 ENOG4105CZN Potassium uptake protein AF2641_07455 ENOG4105ER2 Ompa motb domain protein AF2641_07460 ENOG4105E14 MotA TolQ exbB proton channel AF2641_07465 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AF2641_07470 ENOG4105DJ4 phosphatidylserine decarboxylase AF2641_07480 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AF2641_07485 ENOG4105CQW ribosome biogenesis GTPase YqeH AF2641_07490 ENOG4105E2X shikimate dehydrogenase AF2641_07495 ENOG410812S Rna-binding protein AF2641_07500 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AF2641_07505 ENOG4108WF2 Metal Dependent Phosphohydrolase AF2641_07515 ENOG4105DXX methyltransferase AF2641_07525 ENOG4105KQC Competence protein AF2641_07530 ENOG4108UK2 deaminase AF2641_07535 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AF2641_07545 ENOG4105TQK DNA polymerase iii, delta' subunit AF2641_07555 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AF2641_07560 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) AF2641_07565 ENOG4108ZRV stage ii sporulation protein p AF2641_07575 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AF2641_07580 ENOG4105CSA Coproporphyrinogen iii oxidase AF2641_07585 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AF2641_07590 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AF2641_07595 ENOG4105CFG Acts as a chaperone (By similarity) AF2641_07600 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AF2641_07605 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AF2641_07610 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AF2641_07615 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AF2641_07620 ENOG4105VCC 30S ribosomal protein S21 AF2641_07625 ENOG4105KTH gatB Yqey AF2641_07630 ENOG4105F7J membrane-bound serine protease AF2641_07635 ENOG4105DI5 UPF0365 protein AF2641_07645 ENOG41068P3 sporulation protein YqfC AF2641_07655 ENOG4105C9A Phoh family AF2641_07660 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AF2641_07665 ENOG4107YR5 Diacylglycerol kinase AF2641_07670 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AF2641_07680 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) AF2641_07690 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AF2641_07700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AF2641_07720 ENOG4105EGD dinuclear metal center protein, YbgI family AF2641_07725 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AF2641_07740 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AF2641_07750 ENOG4108JYZ YitT family AF2641_07755 ENOG4105FDK ABC transporter AF2641_07760 ENOG4105FAV ABC, transporter AF2641_07765 ENOG4105N80 Ferric uptake regulator, Fur family AF2641_07770 ENOG4108U5J '-nucleotidase AF2641_07775 ENOG41063Y9 AF2641_07780 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AF2641_07790 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_07815 ENOG4107RF6 penicillin-binding protein AF2641_07820 ENOG4105EXS phosphate abc transporter AF2641_07825 ENOG4105C8U phosphate abc transporter AF2641_07830 ENOG4105E2Z phosphate ABC transporter (Permease AF2641_07835 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AF2641_07840 ENOG4108UTW Plays a role in the regulation of phosphate uptake AF2641_07860 ENOG4105WDJ 50S ribosomal protein L33 AF2641_07865 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AF2641_07870 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AF2641_07880 ENOG4107ZXI Rhomboid family AF2641_07905 ENOG4105E0M Sulfatase AF2641_07920 ENOG4105C5X domain protein AF2641_07955 ENOG4106855 Competence protein AF2641_07995 ENOG4105C0D helicase AF2641_08000 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AF2641_08005 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AF2641_08010 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AF2641_08015 ENOG4105WZW rhodanese family AF2641_08020 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AF2641_08025 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AF2641_08030 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AF2641_08040 ENOG4105KST dependent repressor AF2641_08055 ENOG4105CBJ Metal-dependent enzyme AF2641_08065 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AF2641_08070 ENOG4105DC7 peptidase M24 AF2641_08075 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AF2641_08095 ENOG4105CD2 stage iii sporulation protein aa AF2641_08100 ENOG4105KR5 Stage iii sporulation protein AF2641_08105 ENOG4108CQH stage III sporulation protein AC AF2641_08110 ENOG4105KQ4 Stage iii sporulation protein ad AF2641_08120 ENOG410644B Stage III sporulation protein af AF2641_08140 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AF2641_08145 ENOG4108ZSR alkaline shock protein AF2641_08150 ENOG4105M7K Involved in the transcription termination process (By similarity) AF2641_08155 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AF2641_08160 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AF2641_08165 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AF2641_08175 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AF2641_08180 ENOG4105DX0 Hemolysin A AF2641_08190 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AF2641_08195 ENOG4105S1Z Stage IV sporulation protein B AF2641_08210 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AF2641_08215 ENOG4106CCJ Protein of unknown function (DUF2627) AF2641_08220 ENOG4108JUB Transcriptional regulator AF2641_08235 ENOG4105CKM Branched-chain carboxylic acid kinase AF2641_08250 ENOG4105CPP Dehydrogenase, E1 component AF2641_08255 ENOG4105C7S Dehydrogenase AF2641_08260 ENOG4105CMN Methylmalonyl-coA mutase AF2641_08265 ENOG4105D5P Methylmalonyl-coA mutase AF2641_08275 ENOG4108QEG Membrane AF2641_08280 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AF2641_08285 ENOG4108ZVT methylmalonyl-coA epimerase AF2641_08290 ENOG4108HNZ carboxyl transferase AF2641_08300 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AF2641_08305 ENOG4108V3W Chemotaxis protein, CheW AF2641_08310 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AF2641_08315 ENOG4107XCH Cyclase family AF2641_08320 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AF2641_08325 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AF2641_08355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AF2641_08360 ENOG4105II7 pyrroline-5-carboxylate reductase AF2641_08365 ENOG41069FQ Metallo-beta-lactamase superfamily AF2641_08370 ENOG4108IXY short-chain dehydrogenase reductase AF2641_08375 ENOG4106HZJ AF2641_08395 ENOG4105CPC Aldo Keto reductase AF2641_08400 ENOG4108YZ4 nudix hydrolase AF2641_08405 ENOG4105MZ9 stage II sporulation protein m AF2641_08415 ENOG4105D7V transposase AF2641_08420 ENOG4105I3K Ferric uptake regulator, Fur family AF2641_08430 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AF2641_08450 ENOG4105DZ1 carboxypeptidase AF2641_08455 ENOG41082AN stage II sporulation protein AF2641_08460 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AF2641_08465 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AF2641_08485 ENOG4105CZ3 stage V sporulation protein ad AF2641_08495 ENOG4105G6R Stage v sporulation protein ae AF2641_08505 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AF2641_08510 ENOG4105PTM secreted protein AF2641_08515 ENOG4107ZE5 PPIases accelerate the folding of proteins AF2641_08520 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AF2641_08525 ENOG4108R6K riboflavin synthase, subunit alpha AF2641_08530 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AF2641_08535 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AF2641_08550 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AF2641_08555 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AF2641_08580 ENOG4105CPF Cell wall formation (By similarity) AF2641_08585 ENOG41082BM Transcriptional regulator, arsr family AF2641_08600 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AF2641_08605 ENOG4105DZ1 carboxypeptidase AF2641_08610 ENOG4108JIC nucleoside recognition domain protein AF2641_08625 ENOG4105FE9 pseudouridine synthase AF2641_08630 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AF2641_08635 ENOG4107TWT Cytochrome c biogenesis protein AF2641_08640 ENOG4105CRE cytochrome C AF2641_08645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AF2641_08650 ENOG4105BZU Histidine kinase AF2641_08655 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AF2641_08660 ENOG4105EHG Permease protein AF2641_08665 ENOG4105E0A ABC, transporter AF2641_08670 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AF2641_08675 ENOG4105CIH Imidazole acetol-phosphate transaminase AF2641_08685 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AF2641_08700 ENOG4108WBT adenosyltransferase AF2641_08720 ENOG4107RVV histidinol phosphate phosphatase, hisj family AF2641_08725 ENOG4108JQ1 Dehydrogenase AF2641_08740 ENOG4105T7X AF2641_08745 ENOG4105C9U ATP-dependent DNA helicase RecQ AF2641_08750 ENOG4105I7S Abortive infection protein AF2641_08765 ENOG4105WEF catalase AF2641_08785 ENOG4107RGJ metallophosphoesterase AF2641_08790 ENOG4108XDN Transcriptional regulator AF2641_08795 ENOG4108S6Z Negative regulator of genetic competence AF2641_08810 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AF2641_08815 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AF2641_08820 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AF2641_08825 ENOG4105MSI germination protein ypeb AF2641_08830 ENOG4105F0V Cell wall hydrolase AF2641_08835 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) AF2641_08850 ENOG4105CAT Cytidine monophosphate kinase AF2641_08860 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AF2641_08865 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AF2641_08880 ENOG4105S2F AF2641_08885 ENOG41065D1 AF2641_08890 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AF2641_08895 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AF2641_08910 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AF2641_08920 ENOG4105EUJ GTP cyclohydrolase i AF2641_08925 ENOG4105WP2 Tryptophan RNA-binding attenuator protein AF2641_08930 ENOG4105XXQ heptaprenyl diphosphate synthase component I AF2641_08935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AF2641_08945 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AF2641_08950 ENOG4105BZU Histidine kinase AF2641_08955 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AF2641_08960 ENOG4105D49 3-dehydroquinate synthase AF2641_08965 ENOG4105KHN chorismate mutase AF2641_08975 ENOG4108I0Q anthranilate phosphoribosyltransferase AF2641_08980 ENOG4105DK0 Indole-3-glycerol phosphate synthase AF2641_08985 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AF2641_08990 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AF2641_08995 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AF2641_09000 ENOG4105CIH Imidazole acetol-phosphate transaminase AF2641_09010 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AF2641_09020 ENOG4108SXZ UPF0302 protein AF2641_09030 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AF2641_09035 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AF2641_09040 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AF2641_09055 ENOG4108JYZ YitT family AF2641_09060 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AF2641_09065 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AF2641_09070 ENOG4108Z5K methylglyoxal synthase AF2641_09075 ENOG4105FJR Lmbe family AF2641_09080 ENOG4105CPK Glycosyl transferase (Group 1 AF2641_09085 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AF2641_09095 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AF2641_09100 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AF2641_09105 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AF2641_09110 ENOG4105DVT helicase AF2641_09120 ENOG4105YAC AF2641_09135 ENOG4105C5S asparaginyl-tRNA synthetase AF2641_09145 ENOG4105CSM endonuclease III AF2641_09155 ENOG4105BZ4 penicillin-binding protein AF2641_09160 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AF2641_09195 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AF2641_09200 ENOG4105EU9 AF2641_09205 ENOG4105MYT Heat shock protein AF2641_09235 ENOG4105BZW Glycerate kinase AF2641_09240 ENOG4105BZU Histidine kinase AF2641_09245 ENOG4105E0A ABC, transporter AF2641_09255 ENOG4105DQ5 transport system permease protein AF2641_09260 ENOG4105EHG Permease protein AF2641_09265 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AF2641_09270 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AF2641_09275 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AF2641_09280 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AF2641_09300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AF2641_09305 ENOG4105GR3 Histidine kinase AF2641_09315 ENOG4108IXY short-chain dehydrogenase reductase AF2641_09330 ENOG4105D7V transposase AF2641_09365 ENOG4107QI6 Cysteine desulfurase AF2641_09440 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AF2641_09445 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AF2641_09470 ENOG4107R3K hydrolase AF2641_09500 ENOG4105BZU Histidine kinase AF2641_09505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AF2641_09520 ENOG4105VPX protein, conserved in bacteria AF2641_09525 ENOG4105C59 p-type ATPase AF2641_09555 ENOG410681U heavy metal transport detoxification protein AF2641_09560 ENOG4107R16 Multicopper oxidase AF2641_09565 ENOG4105CAQ asparagine synthetase AF2641_09580 ENOG4105CVP deoxyribo-dipyrimidine photolyase AF2641_09605 ENOG4105C5Q Transcriptional regulator AF2641_09610 ENOG4105CBC glutamate synthase AF2641_09615 ENOG4105BZ8 glutamate synthase AF2641_09625 ENOG4105C01 Dihydroxy-acid dehydratase AF2641_09635 ENOG4105C1G acyl-Coa dehydrogenase AF2641_09645 ENOG4108JPW Aminotransferase AF2641_09655 ENOG4107QTZ amino acid AF2641_09660 ENOG4105C7K acetolactate synthase AF2641_09665 ENOG4105C26 Dehydrogenase AF2641_09675 ENOG4105BZJ Electron transfer flavoprotein AF2641_09680 ENOG4105C10 Electron transfer flavoprotein AF2641_09685 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AF2641_09690 ENOG41090P5 ferredoxin-like protein AF2641_09715 ENOG4105EJ5 oxidoreductase gamma subunit AF2641_09720 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AF2641_09755 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AF2641_09760 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AF2641_09770 ENOG4108IUX (ABC) transporter AF2641_09790 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AF2641_09800 ENOG4105CEY Amp-dependent synthetase and ligase AF2641_09805 ENOG4105CSU acyl-Coa dehydrogenase AF2641_09810 ENOG4108UT2 hemolysin iii AF2641_09830 ENOG4105DWD nucleoside recognition domain protein AF2641_09840 ENOG4107R7I amino acid AF2641_09845 ENOG4105DSE periplasmic solute binding protein AF2641_09850 ENOG4105DIK (ABC) transporter AF2641_09855 ENOG4105CC5 ABC transporter AF2641_09860 ENOG4105CC5 ABC transporter AF2641_09880 ENOG4105CDW Resistance protein AF2641_09915 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_09925 ENOG4105C2F Histidine kinase AF2641_09930 ENOG4108VAC response regulator AF2641_09935 ENOG4105DFW ABC transporter AF2641_09940 ENOG4105C2J ABC transporter AF2641_09945 ENOG4108HWW ABC transporter AF2641_09955 ENOG4105C32 Amino acid ABC transporter (Permease) AF2641_09960 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AF2641_09965 ENOG4105C0Z ABC transporter AF2641_09970 ENOG4108IV0 ABC, transporter AF2641_09975 ENOG4105DTQ mandelate racemase muconate lactonizing AF2641_09985 ENOG4105ZKE UPF0349 protein AF2641_10015 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AF2641_10020 ENOG4108V06 Glutathione peroxidase AF2641_10025 ENOG4108KS4 Spore coat protein AF2641_10030 ENOG4107SBE Glycosyl transferase (Group 1 AF2641_10040 ENOG4105BZ1 (ABC) transporter AF2641_10045 ENOG4105BZ1 (ABC) transporter AF2641_10075 ENOG4105DVT helicase AF2641_10080 ENOG4105KTU Transcriptional regulator, arsr family AF2641_10090 ENOG4105BZU Histidine kinase AF2641_10110 ENOG4105CJ1 ABC, transporter AF2641_10120 ENOG4107Y9E nuclease AF2641_10125 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AF2641_10130 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AF2641_10135 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AF2641_10140 ENOG4105CGU Enoyl-CoA hydratase AF2641_10145 ENOG4108MJI response regulator AF2641_10165 ENOG4106YBV Methyl-accepting chemotaxis AF2641_10175 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) AF2641_10185 ENOG4105BZU Histidine kinase AF2641_10190 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AF2641_10195 ENOG4105DVT helicase AF2641_10200 ENOG4105CTD carboxy-peptidase AF2641_10205 ENOG4107RQ2 Cytochrome c oxidase, subunit I AF2641_10210 ENOG4105NAA Cytochrome C oxidase, subunit II AF2641_10230 ENOG41065KQ synthase AF2641_10240 ENOG410890F Dynamin family AF2641_10250 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AF2641_10260 ENOG41075ZD Small, acid-soluble spore protein N AF2641_10265 ENOG41067CD Small, acid-soluble spore protein Tlp AF2641_10275 ENOG4105W8X HesB YadR YfhF-family protein AF2641_10295 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AF2641_10310 ENOG4108N23 SpoOM-related protein AF2641_10315 ENOG4106Z5R AF2641_10325 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AF2641_10330 ENOG4108VXD carboxy-peptidase AF2641_10350 ENOG4105FR1 rard protein AF2641_10375 ENOG4105BZU Histidine kinase AF2641_10385 ENOG4105WEF catalase AF2641_10390 ENOG4105C7B Threonine dehydratase AF2641_10410 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AF2641_10415 ENOG4105DVE abc transporter atp-binding protein AF2641_10425 ENOG4105CFP Peptidase U32 AF2641_10435 ENOG4105VEQ Cold shock protein AF2641_10450 ENOG4105CJ1 ABC, transporter AF2641_10455 ENOG4108TU7 Inherit from COG: (ABC) transporter AF2641_10460 ENOG4105P8F nudix hydrolase AF2641_10475 ENOG4108B1Q Ribonuclease AF2641_10480 ENOG4105CKI cobalamin synthesis protein AF2641_10485 ENOG41082YX Transcriptional regulator, arsr family AF2641_10490 ENOG4107R5R arsenical pump membrane protein AF2641_10495 ENOG4108UXE Protein tyrosine phosphatase AF2641_10505 ENOG4105BZ1 (ABC) transporter AF2641_10520 ENOG4105DKW ABC transporter AF2641_10565 ENOG4105C9U ATP-dependent DNA helicase RecQ AF2641_10585 ENOG4107T89 von Willebrand factor, type A AF2641_10590 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AF2641_10595 ENOG4105XTG Pfam:DUF156 AF2641_10605 ENOG4105CIY formyltetrahydrofolate deformylase AF2641_10610 ENOG4108QTI )-transporter AF2641_10615 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AF2641_10620 ENOG4105WDJ 50S ribosomal protein L33 AF2641_10625 ENOG4107414 GntR family transcriptional regulator AF2641_10630 ENOG4105CG3 alpha amylase, catalytic region AF2641_10635 ENOG4105C5Y PTS System AF2641_10650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AF2641_10655 ENOG4105K4P CoA-binding domain protein AF2641_10660 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AF2641_10665 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AF2641_10675 ENOG41090WU lipolytic protein G-D-S-L family AF2641_10680 ENOG4108KF3 Electron transport protein SCO1 SenC AF2641_10695 ENOG4105C7B Threonine dehydratase AF2641_10700 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AF2641_10705 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AF2641_10710 ENOG4105C45 hydrogenase expression formation protein (HypE) AF2641_10715 ENOG4105CQS hydrogenase expression formation protein HypD AF2641_10720 ENOG41083WG hydrogenase assembly chaperone AF2641_10730 ENOG4107RSS Hydrogenase accessory protein HypB AF2641_10735 ENOG41082RJ Hydrogenase nickel insertion protein HypA AF2641_10745 ENOG4108USZ hydrogenase AF2641_10755 ENOG4105DPX Hydrogenase, large subunit AF2641_10760 ENOG4105E3S small subunit AF2641_10765 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AF2641_10770 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AF2641_10790 ENOG4107YX5 Pfam:DUF548 AF2641_10795 ENOG4108Y6J UPF0403 protein AF2641_10800 ENOG4105CVG Homoserine O-transsuccinylase AF2641_10835 ENOG4107SDU Methyl-accepting chemotaxis AF2641_10840 ENOG4105EXQ uroporphyrinogen iii synthase hem4 AF2641_10845 ENOG4105BZU Histidine kinase AF2641_10850 ENOG4105NQC Flavodoxin AF2641_10855 ENOG4105DM4 PTS System AF2641_10860 ENOG4105DE4 1-phosphofructokinase AF2641_10875 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AF2641_10885 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AF2641_10890 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AF2641_10895 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AF2641_10945 ENOG4108I0Z Aconitate hydratase AF2641_10950 ENOG410746C Acid-soluble spore protein O AF2641_10960 ENOG4107DZX Small, acid-soluble spore protein P AF2641_10975 ENOG4107YTP response regulator receiver protein AF2641_10980 ENOG4107QIV Cytochrome c biogenesis protein AF2641_10985 ENOG4105VXM UPF0154 protein AF2641_10995 ENOG4105VPS UPF0291 protein AF2641_11000 ENOG4108SVB resolvase AF2641_11005 ENOG41067Z0 domain protein AF2641_11010 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AF2641_11015 ENOG4105C5F glutamine synthetase AF2641_11020 ENOG4105KV4 Transcriptional regulator AF2641_11025 ENOG4105CXI aluminum resistance protein AF2641_11030 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AF2641_11035 ENOG4105EN6 Membrane AF2641_11040 ENOG4105CHU acetyl-coa acetyltransferase AF2641_11045 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AF2641_11050 ENOG4105CEY Amp-dependent synthetase and ligase AF2641_11060 ENOG4105C1G acyl-Coa dehydrogenase AF2641_11070 ENOG4106F1P AAA ATPase, central domain protein AF2641_11075 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AF2641_11080 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AF2641_11085 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AF2641_11090 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AF2641_11105 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AF2641_11110 ENOG4105DQU oxidoreductase, subunit beta AF2641_11115 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AF2641_11120 ENOG4108IGT Dipeptidase AF2641_11125 ENOG4105MCT stage V sporulation protein S AF2641_11130 ENOG4105D48 metallophosphoesterase AF2641_11135 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) AF2641_11140 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AF2641_11145 ENOG4105CEV competence damage-inducible protein AF2641_11150 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AF2641_11165 ENOG4105XZV Protein of unknown function (DUF3243) AF2641_11170 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AF2641_11185 ENOG4105C6T cysteine synthase AF2641_11190 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AF2641_11200 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AF2641_11215 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AF2641_11230 ENOG4107VFR oxidoreductase AF2641_11240 ENOG4108MDK Dehydrogenase AF2641_11260 ENOG4105KK4 UPF0060 membrane protein AF2641_11270 ENOG4105BZU Histidine kinase AF2641_11295 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AF2641_11305 ENOG4105ETD TRANSCRIPTIONal AF2641_11315 ENOG4105K4I Scp-like extracellular AF2641_11325 ENOG4107HP6 Transcriptional regulator AF2641_11330 ENOG4105C82 Malate synthase AF2641_11345 ENOG4105CIG ABC transporter AF2641_11360 ENOG4105F0V Cell wall hydrolase AF2641_11365 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AF2641_11370 ENOG41090MY MarR family Transcriptional regulator AF2641_11375 ENOG4108VGI doxx family AF2641_11390 ENOG4105EU0 Major facilitator Superfamily AF2641_11400 ENOG4107QM2 Aldo Keto reductase AF2641_11405 ENOG41090T1 Membrane AF2641_11415 ENOG41082BM Transcriptional regulator, arsr family AF2641_11420 ENOG4105K8R UPF0145 protein AF2641_11425 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AF2641_11430 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AF2641_11435 ENOG4105DUM transcriptional regulator, lysR family AF2641_11445 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AF2641_11455 ENOG4105C26 Dehydrogenase AF2641_11465 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AF2641_11480 ENOG4107QJE Chromosome Partitioning Protein AF2641_11490 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AF2641_11495 ENOG4105KIR Thiol-disulfide oxidoreductase dcc AF2641_11540 ENOG4105C3K feS assembly ATPase SufC AF2641_11570 ENOG4105DWT malate dehydrogenase (quinone) AF2641_11595 ENOG4105CHH sulfate transporter AF2641_11605 ENOG4107YZX Universal stress protein AF2641_11610 ENOG4105PNM synthesis protein AF2641_11620 ENOG4108N3W hemolysin secretion protein AF2641_11625 ENOG4105CK7 Sodium proline symporter AF2641_11635 ENOG4105C26 Dehydrogenase AF2641_11640 ENOG4107YHD transcriptional regulator AF2641_11650 ENOG4105UIB (ABC) transporter AF2641_11655 ENOG4108JQ9 ABC transporter AF2641_11660 ENOG4105DIH basic membrane AF2641_11665 ENOG4105FDP GntR family transcriptional regulator AF2641_11670 ENOG4105CNU cell division protein FtsK AF2641_11680 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AF2641_11690 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AF2641_11700 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AF2641_11705 ENOG4108S0H Dipicolinic acid synthetase, b subunit AF2641_11710 ENOG4105E35 Dipicolinate synthase subunit A AF2641_11720 ENOG4105C1V Peptidase, M16 AF2641_11730 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AF2641_11735 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AF2641_11740 ENOG4105DTN riboflavin biosynthesis protein ribF AF2641_11745 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AF2641_11750 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AF2641_11755 ENOG4105W7A Protein of unknown function (DUF503) AF2641_11760 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AF2641_11765 ENOG4105VHM ribosomal protein AF2641_11770 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AF2641_11775 ENOG4105CHV Transcription elongation factor NusA AF2641_11780 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AF2641_11790 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AF2641_11795 ENOG4105DZP Membrane-associated zinc metalloprotease AF2641_11800 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AF2641_11805 ENOG4105KNE Phosphatidate cytidylyltransferase AF2641_11810 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AF2641_11815 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AF2641_11820 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AF2641_11825 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AF2641_11830 ENOG4105CE9 30S ribosomal protein S2 AF2641_11845 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AF2641_11855 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AF2641_11865 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis AF2641_11870 ENOG4105CBS Chea signal transduction histidine kinase AF2641_11875 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AF2641_11885 ENOG4105FZW flagellar biosynthesis regulator FlhF AF2641_11890 ENOG4105D7B Flagellar biosynthesis protein flha AF2641_11895 ENOG4105D00 flagellar biosynthetic protein flhB AF2641_11900 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AF2641_11905 ENOG4105VS8 Flagellar biosynthetic protein fliq AF2641_11910 ENOG4105CN7 Flagellar biosynthetic protein FliP AF2641_11920 ENOG4107YTP response regulator receiver protein AF2641_11925 ENOG4105DD5 Flagellar motor switch protein AF2641_11930 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AF2641_11940 ENOG41068WV flagellar FlbD family protein AF2641_11945 ENOG4108JQA flagellar AF2641_11955 ENOG410822I Flagellar hook capping protein AF2641_11960 ENOG410696Y Flagellar hook-length control protein AF2641_11970 ENOG4106YF4 Flagellar biosynthesis chaperone AF2641_11985 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AF2641_11990 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AF2641_11995 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AF2641_12000 ENOG4108ZC9 flagellar basal-body rod protein flgc AF2641_12005 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AF2641_12010 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) AF2641_12015 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AF2641_12020 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AF2641_12025 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AF2641_12030 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) AF2641_12035 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AF2641_12040 ENOG4105C79 DNA protecting protein DprA AF2641_12045 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AF2641_12050 ENOG4105CMV Succinyl-CoA synthetase subunit beta AF2641_12055 ENOG4105D00 flagellar biosynthetic protein flhB AF2641_12065 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AF2641_12070 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AF2641_12080 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AF2641_12085 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AF2641_12090 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AF2641_12100 ENOG4105VB6 UPF0109 protein AF2641_12105 ENOG4105K5M 30s ribosomal protein S16 AF2641_12115 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) AF2641_12120 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AF2641_12125 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AF2641_12130 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AF2641_12135 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AF2641_12140 ENOG4105CHR reductase AF2641_12145 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AF2641_12150 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AF2641_12155 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) AF2641_12160 ENOG4105CB5 ATP-dependent DNA helicase recG AF2641_12165 ENOG4105EJQ L-serine dehydratase AF2641_12175 ENOG4105DP4 dak2 domain fusion protein ylov AF2641_12180 ENOG4108ZAA Alkaline-shock protein AF2641_12185 ENOG4105VB9 50S ribosomal protein l28 AF2641_12195 ENOG4105FJ0 thiamine AF2641_12200 ENOG4105DJV ribulose-phosphate 3-epimerase AF2641_12205 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AF2641_12210 ENOG4105D9P serine threonine protein kinase AF2641_12215 ENOG4108ZF3 Phosphatase AF2641_12220 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AF2641_12225 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AF2641_12230 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AF2641_12235 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AF2641_12240 ENOG4105C25 Primosomal protein n' AF2641_12245 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AF2641_12250 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AF2641_12255 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AF2641_12260 ENOG4105DSJ YicC domain protein AF2641_12270 ENOG4105F23 Fibronectin-binding protein AF2641_12325 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AF2641_12330 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AF2641_12335 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AF2641_12350 ENOG4105CD3 dihydroorotase AF2641_12355 ENOG4105CXT aspartate transcarbamylase AF2641_12365 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AF2641_12370 ENOG4105C34 Pseudouridine synthase AF2641_12375 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AF2641_12385 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AF2641_12395 ENOG4105DBK s4 domain protein AF2641_12400 ENOG41067XK integral membrane protein AF2641_12405 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AF2641_12410 ENOG4105DFA alanine racemase domain protein AF2641_12415 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AF2641_12420 ENOG4105WR5 sporulation protein, YlmC YmxH family AF2641_12430 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AF2641_12435 ENOG4108AWX Sporulation factor SpoIIGA AF2641_12440 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AF2641_12445 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AF2641_12450 ENOG4105K67 small basic protein AF2641_12460 ENOG4108R2U division initiation protein AF2641_12465 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AF2641_12470 ENOG4105D4A Cell wall formation (By similarity) AF2641_12475 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AF2641_12480 ENOG4105CNI cell division protein FtsW AF2641_12485 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AF2641_12490 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AF2641_12495 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AF2641_12500 ENOG4105CJN penicillin-binding protein AF2641_12505 ENOG4105CJN penicillin-binding protein AF2641_12510 ENOG41068DC Essential cell division protein (By similarity) AF2641_12515 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AF2641_12520 ENOG41074B2 UPF0747 protein AF2641_12540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AF2641_12545 ENOG41067VY 50S ribosomal protein L32 AF2641_12550 ENOG4105KNH Nucleic acid-binding protein AF2641_12555 ENOG4105CDE UPF0348 protein AF2641_12560 ENOG41063PX domain protein AF2641_12565 ENOG4105D78 K07001 NTE family protein AF2641_12570 ENOG4105H20 Sporulation integral membrane protein YlbJ AF2641_12575 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AF2641_12580 ENOG4106H78 methyltransferase AF2641_12595 ENOG4105WUC UPF0298 protein AF2641_12620 ENOG4106UY4 Inherit from COG: Scp-like extracellular AF2641_12625 ENOG41080XQ Signal transduction protein with cbs domains AF2641_12640 ENOG4108REF Sporulation integral membrane protein ytvi AF2641_12675 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AF2641_12680 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AF2641_12685 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AF2641_12690 ENOG4105CNI cell division protein FtsW AF2641_12695 ENOG4105ZPI UPF0358 protein AF2641_12705 ENOG4108IAB Phoh family AF2641_12730 ENOG4105QA2 AF2641_12735 ENOG4105CI3 gtp-binding protein typa AF2641_12745 ENOG4105ECY inositol monophosphatase AF2641_12755 ENOG4105WBI UPF0223 protein AF2641_12760 ENOG4105EA8 2-Nitropropane dioxygenase AF2641_12765 ENOG4105CXN decarboxylase AF2641_12815 ENOG4108X4Q Hydrolase AF2641_12820 ENOG4106148 UPF0356 protein AF2641_12825 ENOG4105CN5 Metallo-Beta-Lactamase AF2641_12835 ENOG4107ZYR domain protein AF2641_12840 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AF2641_12845 ENOG4105CH2 amidohydrolase AF2641_12850 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AF2641_12860 ENOG4107IN1 Protein of unknown function (DUF1797) AF2641_12870 ENOG4105EPM Diguanylate phosphodiesterase AF2641_12875 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AF2641_12890 ENOG4105WMR Protein CrcB homolog AF2641_12895 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AF2641_12900 ENOG4107R33 ppx gppa phosphatase AF2641_12905 ENOG4105UIN AF2641_12910 ENOG4105BZU Histidine kinase AF2641_12920 ENOG4108B31 Spore germination protein AF2641_12930 ENOG4105BZU Histidine kinase AF2641_12935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AF2641_12945 ENOG4107QJZ Glycosyl transferase, family 2 AF2641_12955 ENOG4105BZU Histidine kinase AF2641_12960 ENOG4107R88 Chemotaxis protein (CheV) AF2641_12975 ENOG4108HGU Histidine kinase AF2641_12990 ENOG4105CHM Aminotransferase AF2641_12995 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AF2641_13000 ENOG4105CHR reductase AF2641_13010 ENOG4105BZU Histidine kinase AF2641_13015 ENOG4108TQ9 Histidine kinase AF2641_13020 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AF2641_13040 ENOG4105CID antiterminator AF2641_13045 ENOG4105DQF Hydrolase AF2641_13050 ENOG41068JE domain protein AF2641_13065 ENOG4105KJM monovalent cation h antiporter subunit g AF2641_13075 ENOG4105SC1 monovalent cation H antiporter subunit E AF2641_13080 ENOG4108JPZ Monovalent cation H antiporter subunit D AF2641_13085 ENOG4108ZE9 Monovalent cation H antiporter subunit C AF2641_13090 ENOG4105HC0 Na H antiporter AF2641_13095 ENOG4105D65 subunit l AF2641_13100 ENOG4106YBV Methyl-accepting chemotaxis AF2641_13130 ENOG4105BZU Histidine kinase AF2641_13160 ENOG4105K4T epimerase AF2641_13180 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AF2641_13185 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase AF2641_13190 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AF2641_13195 ENOG4108UTW Plays a role in the regulation of phosphate uptake AF2641_13205 ENOG4108NVR Methyl-accepting chemotaxis AF2641_13215 ENOG4108K88 Membrane AF2641_13230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AF2641_13235 ENOG4105BZU Histidine kinase AF2641_13240 ENOG4107SDU Methyl-accepting chemotaxis AF2641_13260 ENOG4105CJ1 ABC, transporter AF2641_13265 ENOG4105D5Q Arginine ornithine antiporter AF2641_13280 ENOG4105BZU Histidine kinase AF2641_13290 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AF2641_13295 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AF2641_13300 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) AF2641_13305 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate AF2641_13315 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AF2641_13320 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AF2641_13325 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AF2641_13330 ENOG4105FCA ABC transporter periplasmic-binding protein YphF AF2641_13335 ENOG4105C2J ABC transporter AF2641_13340 ENOG4107SDZ Galactoside transport system permease protein mglC AF2641_13345 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_13350 ENOG4105BZU Histidine kinase AF2641_13355 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AF2641_13360 ENOG4107QR9 Iron-sulfur cluster binding protein AF2641_13365 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AF2641_13370 ENOG4105JXH GntR family transcriptional regulator AF2641_13375 ENOG4105DAA L-lactate AF2641_13385 ENOG4105D7V transposase AF2641_13415 ENOG4105DRS transport system, permease AF2641_13430 ENOG4107URF beta-phospho-glucomutase AF2641_13435 ENOG4105C71 hydrolase family 65, central catalytic AF2641_13440 ENOG4105ETE Transcriptional regulator (LacI family AF2641_13450 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AF2641_13460 ENOG4105CQB FAD linked oxidase domain protein AF2641_13465 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AF2641_13475 ENOG41090A1 ferritin AF2641_13480 ENOG4107TS3 membrane protein, TerC AF2641_13485 ENOG4105CUB amino acid AF2641_13510 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AF2641_13515 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AF2641_13530 ENOG4105C6Z Gluconate AF2641_13535 ENOG4105CMG Carbohydrate kinase AF2641_13545 ENOG4106M28 alanine racemase domain protein AF2641_13560 ENOG4108IJ0 Aspartate ammonia-lyase AF2641_13565 ENOG4105HDK L-asparaginase AF2641_13570 ENOG4108IMY Transcriptional regulator AF2641_13575 ENOG4105G0J serine threonine protein kinase AF2641_13595 ENOG4105MZG transcriptional modulator of maze toxin, mazf AF2641_13600 ENOG4106A2Z transcriptional regulator antitoxin, MazE AF2641_13605 ENOG4105EUB pirin domain protein AF2641_13610 ENOG4105P8F nudix hydrolase AF2641_13615 ENOG4105BZ1 (ABC) transporter AF2641_13620 ENOG4105BZ1 (ABC) transporter AF2641_13635 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AF2641_13660 ENOG4105CAQ asparagine synthetase AF2641_13670 ENOG4105E3B Multicopper oxidase AF2641_13680 ENOG4105C59 p-type ATPase AF2641_13685 ENOG4105VPX protein, conserved in bacteria AF2641_13690 ENOG4107QIV Cytochrome c biogenesis protein AF2641_13695 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AF2641_13720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AF2641_13725 ENOG4105BZU Histidine kinase AF2641_13835 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AF2641_13860 ENOG4105J37 AF2641_13865 ENOG4108AEY RNA polymerase sigma factor AF2641_13910 ENOG4105VTR Integrase AF2641_13930 ENOG4105C28 cystathionine AF2641_13935 ENOG4105C28 cystathionine AF2641_13940 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein AF2641_13945 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AF2641_13960 ENOG4108ZMI UPF0477 protein AF2641_13970 ENOG4105H67 Protein of unknown function (DUF421) AF2641_13975 ENOG4105ENA helicase AF2641_13995 ENOG4105SZ6 Thioredoxin AF2641_14000 ENOG4108QY0 Membrane AF2641_14015 ENOG4105CZ3 stage V sporulation protein ad AF2641_14020 ENOG41090VF Stage v sporulation protein ac AF2641_14075 ENOG4108IAJ Nad-dependent epimerase dehydratase AF2641_14080 ENOG4107SBE Glycosyl transferase (Group 1 AF2641_14105 ENOG4105CJW magnesium transporter AF2641_14125 ENOG4107S1Q Phosphatase AF2641_14130 ENOG4105EMS pseudouridine synthase AF2641_14135 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AF2641_14145 ENOG4106EFP UPF0738 protein AF2641_14150 ENOG4105MIX Adenylate cyclase AF2641_14155 ENOG4105E4C Lytic transglycosylase catalytic AF2641_14160 ENOG4108Z18 K06886 hemoglobin AF2641_14165 ENOG4105T58 Dithiol-disulfide isomerase AF2641_14170 ENOG4105DPN Oligoendopeptidase f AF2641_14180 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis AF2641_14185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AF2641_14190 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) AF2641_14200 ENOG4108JQ7 (ABC) transporter AF2641_14210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AF2641_14215 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AF2641_14235 ENOG4105C31 Tryptophanyl-tRNA synthetase AF2641_14240 ENOG4108KU1 UPF0736 protein AF2641_14255 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AF2641_14260 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AF2641_14265 ENOG4107RMD Basic membrane lipoprotein AF2641_14280 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AF2641_14290 ENOG4105DBV ornithine carbamoyltransferase AF2641_14310 ENOG4105CAS nag kinase AF2641_14315 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AF2641_14320 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AF2641_14325 ENOG4107V6Q Cyclic nucleotide-binding domain AF2641_14335 ENOG4108MXZ Esterase AF2641_14340 ENOG4108KP7 hydrolase AF2641_14350 ENOG4107AYK membrAne AF2641_14355 ENOG4105EPR degv family AF2641_14365 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AF2641_14370 ENOG4105DIH basic membrane AF2641_14375 ENOG4108VPT UPF0234 protein AF2641_14400 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AF2641_14405 ENOG4105EG2 ABC transporter, permease AF2641_14415 ENOG4107FKK extracellular solute-binding protein family 1 AF2641_14425 ENOG4106HBX Transcriptional Regulator AraC Family AF2641_14430 ENOG4105UQX Mate efflux family protein AF2641_14435 ENOG4105EWK phytoene AF2641_14440 ENOG41076QQ Glycosyl transferase, family 2 AF2641_14455 ENOG4105FE1 phytoene synthase AF2641_14470 ENOG4105CAQ asparagine synthetase AF2641_14480 ENOG4105BZU Histidine kinase AF2641_14485 ENOG4105YHS UPF0344 protein AF2641_14490 ENOG4105C8Y Acetylornithine aminotransferase AF2641_14495 ENOG4105ERH Fumarylacetoacetate hydrolase AF2641_14510 ENOG4105CEY Amp-dependent synthetase and ligase AF2641_14555 ENOG4105EYH Exonuclease AF2641_14565 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AF2641_14570 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AF2641_14580 ENOG4105XVF Competence transcription factor AF2641_14590 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AF2641_14595 ENOG4108ZX6 Electron transport protein SCO1 SenC AF2641_14600 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_14605 ENOG4105C8Q Methyl-accepting chemotaxis AF2641_14610 ENOG4105BZU Histidine kinase AF2641_14620 ENOG4105C7J ABC transporter, permease