locus-tag	class	description
AFK25_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
AFK25_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
AFK25_00015	ENOG410848D	S4 domain protein YaaA
AFK25_00020	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
AFK25_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AFK25_00030	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AFK25_00035	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
AFK25_00070	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
AFK25_00080	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
AFK25_00085	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
AFK25_00095	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
AFK25_00105	ENOG4105ZMH	deoxynucleoside kinase
AFK25_00115	ENOG4108Z6B	deaminase
AFK25_00120	ENOG4105C6E	dna polymerase iii
AFK25_00125	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
AFK25_00130	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
AFK25_00175	ENOG4105CXN	decarboxylase
AFK25_00180	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AFK25_00185	ENOG4105FA2	dna polymerase iii
AFK25_00190	ENOG4105MA4	psp1 domain protein
AFK25_00195	ENOG4105QD5	Involved in initiation control of chromosome replication (By similarity)
AFK25_00200	ENOG41060K3	Methyltransferase
AFK25_00205	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
AFK25_00210	ENOG4105KRN	Transcriptional regulator, abrb family
AFK25_00220	ENOG4105F8V	Hydrolase, tatD family
AFK25_00225	ENOG41069ER	domain protein
AFK25_00230	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
AFK25_00235	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AFK25_00240	ENOG4105XFA	sporulation peptidase YabG
AFK25_00245	ENOG4105W42	Veg protein
AFK25_00250	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
AFK25_00255	ENOG4105DFT	pur operon repressor
AFK25_00260	ENOG4105KME	endoribonuclease L-psp
AFK25_00265	ENOG4105K4W	Could be involved in septation (By similarity)
AFK25_00270	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
AFK25_00275	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
AFK25_00280	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
AFK25_00285	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
AFK25_00295	ENOG4108JA2	transcriptioN-repair coupling factor
AFK25_00300	ENOG4108M14	stage v sporulation protein t
AFK25_00310	ENOG4108IY2	MazG family
AFK25_00315	ENOG41082I2	s4 domain protein
AFK25_00320	ENOG4105VYY	sporulation protein yabp
AFK25_00335	ENOG41060GV	RNA binding s1 domain protein
AFK25_00365	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
AFK25_00370	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
AFK25_00375	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AFK25_00380	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
AFK25_00385	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
AFK25_00390	ENOG4105C6T	cysteine synthase
AFK25_00395	ENOG4105CRQ	synthase (Component I)
AFK25_00400	ENOG4105DDQ	anthranilate synthase
AFK25_00405	ENOG41082R7	4-amino-4-deoxychorismate lyase EC 4.1.3.38
AFK25_00410	ENOG4105EEI	dihydropteroate synthase
AFK25_00415	ENOG4105KRF	dihydroneopterin aldolase
AFK25_00420	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AFK25_00425	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
AFK25_00455	ENOG4108Z0C	Uvrb UvrC protein
AFK25_00460	ENOG41066A3	ATP guanido phosphotransferase
AFK25_00470	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
AFK25_00475	ENOG4105CTP	PilT protein domain protein
AFK25_00480	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
AFK25_00485	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
AFK25_00490	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AFK25_00495	ENOG4105D7W	serine acetyltransferase
AFK25_00500	ENOG4105C8N	cysteinyl-tRNA synthetase
AFK25_00505	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AFK25_00510	ENOG4105C2N	RNA methyltransferase TrmH family group 3
AFK25_00515	ENOG4105M0M	Tetracycline resistance protein
AFK25_00520	ENOG4105QIV	RNA polymerase
AFK25_00530	ENOG410683Z	Preprotein translocase SecE subunit
AFK25_00535	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
AFK25_00540	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
AFK25_00545	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
AFK25_00550	ENOG4108VZM	50s ribosomal protein L10
AFK25_00555	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
AFK25_00560	ENOG4107Y49	methyltransferase
AFK25_00565	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AFK25_00570	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AFK25_00575	ENOG4105XPM	ribosomal protein
AFK25_00580	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
AFK25_00585	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
AFK25_00590	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
AFK25_00595	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AFK25_00600	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
AFK25_00605	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
AFK25_00610	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
AFK25_00615	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
AFK25_00620	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFK25_00625	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
AFK25_00630	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
AFK25_00635	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
AFK25_00640	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
AFK25_00645	ENOG41082SA	50s ribosomal protein l29
AFK25_00650	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
AFK25_00655	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
AFK25_00660	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
AFK25_00665	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFK25_00670	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
AFK25_00675	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
AFK25_00680	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
AFK25_00685	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
AFK25_00690	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
AFK25_00695	ENOG4105VPB	50S ribosomal protein L30
AFK25_00700	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
AFK25_00705	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
AFK25_00710	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
AFK25_00715	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
AFK25_00720	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
AFK25_00725	ENOG41067V7	50S ribosomal protein L36
AFK25_00730	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFK25_00735	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
AFK25_00740	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AFK25_00745	ENOG4108ZT0	50S ribosomal protein l17
AFK25_00750	ENOG4108JJB	ABC transporter
AFK25_00755	ENOG4108JJB	ABC transporter
AFK25_00760	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
AFK25_00765	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AFK25_00770	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
AFK25_00775	ENOG4108UJD	30S ribosomal protein S9
AFK25_00790	ENOG4105D1F	ATP-binding protein
AFK25_00805	ENOG4108NMV	polysaccharide deacetylase
AFK25_00880	ENOG4105EMN	RNA polymerase sigma factor
AFK25_00890	ENOG4105C8B	TIGR00159 family
AFK25_00895	ENOG4107U5W	ybbr family
AFK25_00900	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
AFK25_00905	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
AFK25_00930	ENOG4108UZ3	Transporter
AFK25_00935	ENOG4108MCI	Transcriptional regulator, ARAC family
AFK25_00960	ENOG4105WH1	Two component transcriptional regulator luxr family
AFK25_00975	ENOG4107TXC	Transcriptional regulator
AFK25_00980	ENOG4105CAY	ferredoxin--nadp reductase
AFK25_00990	ENOG4105D22	carbon starvation protein
AFK25_01005	ENOG4105C1G	acyl-Coa dehydrogenase
AFK25_01010	ENOG4105CEY	Amp-dependent synthetase and ligase
AFK25_01015	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
AFK25_01020	ENOG4106063	Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
AFK25_01025	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
AFK25_01030	ENOG4105E39	Enoyl-CoA hydratase
AFK25_01035	ENOG4107QX3	carboxylase
AFK25_01040	ENOG4108ZJ4	polysaccharide deacetylase
AFK25_01070	ENOG4105CPF	Cell wall formation (By similarity)
AFK25_01075	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
AFK25_01080	ENOG4105C1J	atp-dependent rna helicase
AFK25_01085	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
AFK25_01090	ENOG4108SGW	outer membrane lipoprotein-sorting protein-like protein
AFK25_01095	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AFK25_01105	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
AFK25_01115	ENOG410906U	SprT-like
AFK25_01155	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
AFK25_01200	ENOG4105K8N	protein family UPF0079, ATPase
AFK25_01205	ENOG41072GX	Peptidase M22 Glycoprotease
AFK25_01210	ENOG410801F	ribosomal-protein-alanine acetyltransferase
AFK25_01215	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AFK25_01220	ENOG4105C5H	ABC transporter
AFK25_01225	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
AFK25_01235	ENOG4108TYN	CAAX amino terminal protease family protein
AFK25_01240	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
AFK25_01245	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AFK25_01255	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AFK25_01260	ENOG4105C7N	Xanthine uracil vitamin C permease
AFK25_01285	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
AFK25_01290	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
AFK25_01295	ENOG4105C83	adenylosuccinate lyase
AFK25_01300	ENOG4105C8V	SAICAR synthetase
AFK25_01305	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
AFK25_01310	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
AFK25_01315	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
AFK25_01325	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
AFK25_01330	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
AFK25_01335	ENOG4105DC1	bifunctional purine biosynthesis protein purh
AFK25_01340	ENOG4105C12	Phosphoribosylglycinamide synthetase
AFK25_01355	ENOG4108R5T	secreted protein
AFK25_01360	ENOG4105KGF	protein, YerC YecD
AFK25_01365	ENOG4108RTE	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity)
AFK25_01375	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AFK25_01385	ENOG4105C26	Dehydrogenase
AFK25_01395	ENOG4105CPN	adenine deaminase
AFK25_01400	ENOG4105BZG	amino acid carrier protein
AFK25_01405	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AFK25_01410	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
AFK25_01415	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AFK25_01430	ENOG4105C26	Dehydrogenase
AFK25_01435	ENOG4105E2S	oxidase) subunit II
AFK25_01450	ENOG41060D1	Quinol oxidase
AFK25_01455	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
AFK25_01465	ENOG41087YS	Phage shock protein A
AFK25_01475	ENOG4105BZU	Histidine kinase
AFK25_01480	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
AFK25_01500	ENOG4105CBD	Diacylglycerol kinase
AFK25_01560	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AFK25_01575	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AFK25_01585	ENOG4105BZU	Histidine kinase
AFK25_01590	ENOG4105E5W	Transporter
AFK25_01610	ENOG4107Y1Y	Methyltransferase
AFK25_01630	ENOG4105BZU	Histidine kinase
AFK25_01635	ENOG4105DU6	RNA polymerase
AFK25_01655	ENOG4105C8Q	Methyl-accepting chemotaxis
AFK25_01660	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
AFK25_01665	ENOG4105BZU	Histidine kinase
AFK25_01675	ENOG4108ZCF	integral membrane protein
AFK25_01680	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
AFK25_01705	ENOG41084AG	Acylphosphatase
AFK25_01715	ENOG41087GM	Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein
AFK25_01720	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
AFK25_01725	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
AFK25_01730	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
AFK25_01735	ENOG4107RIQ	Sulfate adenylate transferase
AFK25_01745	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
AFK25_01755	ENOG41068PA	UPF0435 protein
AFK25_01760	ENOG4105KJF	protein tyrosine phosphatase
AFK25_01770	ENOG4107U9T	Pfam:Ribonuclease_BN
AFK25_01780	ENOG4108ISG	Major Facilitator
AFK25_01785	ENOG4105UPD	Calcium Proton
AFK25_01825	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
AFK25_01835	ENOG4105CNG	UPF0061 protein
AFK25_01855	ENOG4105C8Q	Methyl-accepting chemotaxis
AFK25_01870	ENOG4105CD3	dihydroorotase
AFK25_01875	ENOG4105ECP	epimerase
AFK25_01880	ENOG410902V	Modulates RecA activity (By similarity)
AFK25_01890	ENOG4105DAA	L-lactate
AFK25_01900	ENOG4105XHU	Acid-soluble spore protein K
AFK25_01905	ENOG41067AE	Membrane-bound metal-dependent hydrolase
AFK25_01915	ENOG4106BXE	
AFK25_01925	ENOG4105EVI	UPF0374 protein
AFK25_01930	ENOG4105C3U	ABC transporter
AFK25_01935	ENOG4108JQ7	(ABC) transporter
AFK25_01940	ENOG4105DEF	Extracellular solute-binding protein, family 5
AFK25_01945	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
AFK25_01950	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
AFK25_01955	ENOG4107NBY	Membrane
AFK25_01960	ENOG4105CBC	glutamate synthase
AFK25_01965	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
AFK25_01970	ENOG4108IUW	ABC transporter
AFK25_01990	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFK25_01995	ENOG4105G5W	regulator Fur family
AFK25_02000	ENOG4105TUA	UPF0295 protein
AFK25_02200	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
AFK25_02210	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
AFK25_02215	ENOG4105CYN	Serine protein kinase
AFK25_02220	ENOG4106AKX	UPF0229 protein
AFK25_02260	ENOG4108IMY	Transcriptional regulator
AFK25_02390	ENOG4108N9J	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AFK25_02510	ENOG4105XSJ	toxin secretion phage lysis holin
AFK25_02515	ENOG4108VPC	n-acetylmuramoyl-l-alanine amidase
AFK25_02550	ENOG41085GJ	domain protein
AFK25_02555	ENOG4105VFE	sira family
AFK25_02560	ENOG4105HF9	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
AFK25_02565	ENOG4105VFE	sira family
AFK25_02570	ENOG41087NI	Sulfite exporter TauE/SafE
AFK25_02580	ENOG4107TPS	domain protein
AFK25_02590	ENOG4105C37	(CBS) domain
AFK25_02595	ENOG4108YBP	pseudouridine synthase
AFK25_02605	ENOG4105K63	Thioredoxin
AFK25_02615	ENOG41080XP	Cbs domain
AFK25_02635	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
AFK25_02640	ENOG4105EPW	hflc protein
AFK25_02645	ENOG4107QJR	hflk protein
AFK25_02650	ENOG4105ED1	spovr family
AFK25_02655	ENOG41067TZ	transcriptional regulator, MarR family
AFK25_02660	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AFK25_02680	ENOG4105ETU	transcriptional activator (TenA
AFK25_02685	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
AFK25_02690	ENOG4108JJB	ABC transporter
AFK25_02695	ENOG4108W7F	transporter, permease
AFK25_02700	ENOG4108VEU	Thiamine monophosphate synthase
AFK25_02705	ENOG41080HI	glycine oxidase
AFK25_02710	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
AFK25_02715	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
AFK25_02720	ENOG4105D06	uba thif-type nad fad binding protein
AFK25_02725	ENOG4105DWF	phosphomethylpyrimidine kinase
AFK25_02740	ENOG4105DRP	amino acid AbC transporter
AFK25_02745	ENOG4105CDA	abc transporter atp-binding protein
AFK25_02750	ENOG4105YWU	small acid-soluble spore protein
AFK25_02775	ENOG4108UH6	UPF0754 membrane protein
AFK25_02780	ENOG4105WZB	UPF0342 protein
AFK25_02790	ENOG4105D4P	Coproporphyrinogen iii oxidase
AFK25_02805	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
AFK25_02810	ENOG4105NBU	tryptophan transport protein
AFK25_02820	ENOG41088ZC	Negative regulator of protease production and sporulation (By similarity)
AFK25_02840	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
AFK25_02845	ENOG4105K59	histidine triad (HIT) protein
AFK25_02865	ENOG41085GJ	domain protein
AFK25_02870	ENOG4105Q24	Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation
AFK25_02875	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
AFK25_02880	ENOG4107TTW	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
AFK25_02885	ENOG4105C1Q	protoporphyrinogen oxidase
AFK25_02895	ENOG4105ECB	domain protein
AFK25_02905	ENOG4107T3P	ABC, transporter
AFK25_02920	ENOG4105CG3	alpha amylase, catalytic region
AFK25_02925	ENOG4108RQ5	Beta-lactamase domain-containing protein
AFK25_02940	ENOG4107QN1	sodium solute
AFK25_02965	ENOG4105CEY	Amp-dependent synthetase and ligase
AFK25_02975	ENOG4105C7J	ABC transporter, permease
AFK25_02985	ENOG4105BZU	Histidine kinase
AFK25_03000	ENOG4105D58	Diguanylate phosphodiesterase
AFK25_03005	ENOG4108ZX6	Electron transport protein SCO1 SenC
AFK25_03010	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
AFK25_03020	ENOG4105XVF	Competence transcription factor
AFK25_03030	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AFK25_03035	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
AFK25_03045	ENOG4105EYH	Exonuclease
AFK25_03090	ENOG4105CEY	Amp-dependent synthetase and ligase
AFK25_03105	ENOG4105ERH	Fumarylacetoacetate hydrolase
AFK25_03110	ENOG4105C8Y	Acetylornithine aminotransferase
AFK25_03115	ENOG4105YHS	UPF0344 protein
AFK25_03120	ENOG4105BZU	Histidine kinase
AFK25_03130	ENOG4105CAQ	asparagine synthetase
AFK25_03145	ENOG4105FE1	phytoene synthase
AFK25_03160	ENOG41076QQ	Glycosyl transferase, family 2
AFK25_03170	ENOG4105UQX	Mate efflux family protein
AFK25_03175	ENOG41063TF	transcriptional regulator (AraC
AFK25_03185	ENOG4107FKK	extracellular solute-binding protein family 1
AFK25_03195	ENOG4105EG2	ABC transporter, permease
AFK25_03200	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
AFK25_03220	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
AFK25_03225	ENOG4105W4R	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
AFK25_03235	ENOG4108JJB	ABC transporter
AFK25_03240	ENOG4105E4R	Precorrin-3B C17-methyltransferase
AFK25_03245	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
AFK25_03250	ENOG4108JTQ	reductase
AFK25_03255	ENOG41081F0	Precorrin-8x methylmutase
AFK25_03260	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
AFK25_03265	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
AFK25_03270	ENOG4105DVK	Precorrin-2 c20-methyltransferase
AFK25_03275	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
AFK25_03280	ENOG4108P62	biosynthesis protein (CbiG)
AFK25_03285	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
AFK25_03290	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
AFK25_03295	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
AFK25_03300	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
AFK25_03305	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
AFK25_03320	ENOG4108VPT	UPF0234 protein
AFK25_03325	ENOG4105DIH	basic membrane
AFK25_03330	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
AFK25_03335	ENOG4105EPR	degv family
AFK25_03340	ENOG4107AYK	membrAne
AFK25_03345	ENOG4108KP7	hydrolase
AFK25_03350	ENOG4108MXZ	Esterase
AFK25_03360	ENOG4107V6Q	Cyclic nucleotide-binding domain
AFK25_03365	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
AFK25_03370	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
AFK25_03375	ENOG4105CAS	nag kinase
AFK25_03395	ENOG4105DBV	ornithine carbamoyltransferase
AFK25_03405	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AFK25_03425	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
AFK25_03430	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
AFK25_03445	ENOG4108KU1	UPF0736 protein
AFK25_03450	ENOG4105C31	Tryptophanyl-tRNA synthetase
AFK25_03465	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
AFK25_03470	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
AFK25_03480	ENOG4108JQ7	(ABC) transporter
AFK25_03490	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
AFK25_03495	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
AFK25_03500	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
AFK25_03510	ENOG4105DPN	Oligoendopeptidase f
AFK25_03520	ENOG4105T58	Dithiol-disulfide isomerase
AFK25_03525	ENOG4108Z18	K06886 hemoglobin
AFK25_03530	ENOG4105E4C	Lytic transglycosylase catalytic
AFK25_03535	ENOG4105MIX	Adenylate cyclase
AFK25_03540	ENOG4106EFP	UPF0738 protein
AFK25_03550	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
AFK25_03555	ENOG4105EMS	pseudouridine synthase
AFK25_03560	ENOG4107S1Q	Phosphatase
AFK25_03580	ENOG4105CJW	magnesium transporter
AFK25_03595	ENOG4107SBE	Glycosyl transferase (Group 1
AFK25_03600	ENOG4108IAJ	Nad-dependent epimerase dehydratase
AFK25_03655	ENOG41090VF	Stage v sporulation protein ac
AFK25_03660	ENOG4105CZ3	stage V sporulation protein ad
AFK25_03675	ENOG4108QY0	Membrane
AFK25_03685	ENOG4105SZ6	Thioredoxin
AFK25_03700	ENOG4105ENA	helicase
AFK25_03715	ENOG4105D7V	transposase
AFK25_03720	ENOG4105H67	Protein of unknown function (DUF421)
AFK25_03730	ENOG4108ZMI	UPF0477 protein
AFK25_03745	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
AFK25_03750	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
AFK25_03755	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
AFK25_03760	ENOG4105C28	cystathionine
AFK25_03765	ENOG4105C28	cystathionine
AFK25_03785	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFK25_03880	ENOG4105VTR	Integrase
AFK25_03890	ENOG4105D8V	Glucose sorbosone dehydrogenase
AFK25_03920	ENOG4105D5G	Transposase
AFK25_03945	ENOG4105DZR	Type I site-specific deoxyribonuclease
AFK25_04030	ENOG4105BZ1	(ABC) transporter
AFK25_04035	ENOG4105BZ1	(ABC) transporter
AFK25_04040	ENOG4105EUB	pirin domain protein
AFK25_04055	ENOG4105C5H	ABC transporter
AFK25_04080	ENOG4107SCQ	Iron-containing alcohol dehydrogenase
AFK25_04085	ENOG4105D01	(LipO)protein
AFK25_04090	ENOG4108UMI	ABC transporter, permease
AFK25_04095	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
AFK25_04105	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
AFK25_04125	ENOG4105DTD	Dehydrogenase
AFK25_04130	ENOG4105CY2	Citrate transporter
AFK25_04135	ENOG4108JUB	Transcriptional regulator
AFK25_04145	ENOG4106A2Z	transcriptional regulator antitoxin, MazE
AFK25_04150	ENOG4105MZG	transcriptional modulator of maze toxin, mazf
AFK25_04170	ENOG4105G0J	serine threonine protein kinase
AFK25_04175	ENOG4108IMY	Transcriptional regulator
AFK25_04180	ENOG4105HDK	L-asparaginase
AFK25_04185	ENOG4108IJ0	Aspartate ammonia-lyase
AFK25_04195	ENOG4105BZU	Histidine kinase
AFK25_04205	ENOG4106M28	alanine racemase domain protein
AFK25_04210	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
AFK25_04215	ENOG41089UC	methyltransferase, type 11
AFK25_04240	ENOG4105CUB	amino acid
AFK25_04245	ENOG4107TS3	membrane protein, TerC
AFK25_04250	ENOG41090A1	ferritin
AFK25_04260	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
AFK25_04265	ENOG4105CQB	FAD linked oxidase domain protein
AFK25_04275	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
AFK25_04280	ENOG4105ETE	Transcriptional regulator (LacI family
AFK25_04285	ENOG4105C71	hydrolase family 65, central catalytic
AFK25_04290	ENOG4107URF	beta-phospho-glucomutase
AFK25_04305	ENOG4105DRS	transport system, permease
AFK25_04330	ENOG4105DAA	L-lactate
AFK25_04335	ENOG4105JXH	GntR family transcriptional regulator
AFK25_04340	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
AFK25_04345	ENOG4107QR9	Iron-sulfur cluster binding protein
AFK25_04350	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
AFK25_04355	ENOG4105BZU	Histidine kinase
AFK25_04360	ENOG4105FKZ	Methyl-accepting chemotaxis
AFK25_04365	ENOG4108HWW	ABC transporter
AFK25_04370	ENOG4105C2J	ABC transporter
AFK25_04375	ENOG4105FCA	ABC transporter periplasmic-binding protein YphF
AFK25_04380	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
AFK25_04385	ENOG4105CT5	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity)
AFK25_04390	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
AFK25_04400	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
AFK25_04405	ENOG4105JAS	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity)
AFK25_04410	ENOG4107V49	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
AFK25_04415	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
AFK25_04430	ENOG4105BZU	Histidine kinase
AFK25_04440	ENOG4105D5Q	Arginine ornithine antiporter
AFK25_04445	ENOG4105CJ1	ABC, transporter
AFK25_04465	ENOG4107SDU	Methyl-accepting chemotaxis
AFK25_04470	ENOG4105BZU	Histidine kinase
AFK25_04475	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AFK25_04490	ENOG4108K88	Membrane
AFK25_04500	ENOG4105EC8	Methyl-accepting chemotaxis
AFK25_04510	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
AFK25_04515	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
AFK25_04520	ENOG4107ZAE	6-carboxy-5,6,7,8-tetrahydropterin synthase
AFK25_04525	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
AFK25_04535	ENOG4105K4T	epimerase
AFK25_04560	ENOG4105BZU	Histidine kinase
AFK25_04585	ENOG4106YBV	Methyl-accepting chemotaxis
AFK25_04590	ENOG4105D65	subunit l
AFK25_04595	ENOG4105HC0	Na H antiporter
AFK25_04600	ENOG4108ZE9	Monovalent cation H antiporter subunit C
AFK25_04605	ENOG4108JPZ	Monovalent cation H antiporter subunit D
AFK25_04610	ENOG4105SC1	monovalent cation H antiporter subunit E
AFK25_04615	ENOG4105W4C	monovalent cation H antiporter subunit F
AFK25_04620	ENOG4105KJM	monovalent cation h antiporter subunit g
AFK25_04625	ENOG4107YUH	hydrolase
AFK25_04630	ENOG41068JE	domain protein
AFK25_04640	ENOG4105CID	antiterminator
AFK25_04665	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
AFK25_04670	ENOG4105CHR	reductase
AFK25_04675	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
AFK25_04680	ENOG4105CHM	Aminotransferase
AFK25_04695	ENOG4108HGU	Histidine kinase
AFK25_04710	ENOG4107R88	Chemotaxis protein (CheV)
AFK25_04715	ENOG4105BZU	Histidine kinase
AFK25_04725	ENOG4107QJZ	Glycosyl transferase, family 2
AFK25_04735	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AFK25_04740	ENOG4105BZU	Histidine kinase
AFK25_04750	ENOG4108B31	Spore germination protein
AFK25_04760	ENOG4105BZU	Histidine kinase
AFK25_04765	ENOG4105UIN	
AFK25_04770	ENOG4107R33	ppx gppa phosphatase
AFK25_04775	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AFK25_04795	ENOG4105K6S	Short-chain dehydrogenase reductase Sdr
AFK25_04800	ENOG4105EPM	Diguanylate phosphodiesterase
AFK25_04810	ENOG4107IN1	Protein of unknown function (DUF1797)
AFK25_04820	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
AFK25_04825	ENOG4105CH2	amidohydrolase
AFK25_04830	ENOG4107R19	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFK25_04835	ENOG4107ZYR	domain protein
AFK25_04840	ENOG4105CN5	Metallo-Beta-Lactamase
AFK25_04845	ENOG4106148	UPF0356 protein
AFK25_04850	ENOG4108X4Q	Hydrolase
AFK25_04900	ENOG4105CXN	decarboxylase
AFK25_04920	ENOG4108RDQ	ABC transporter
AFK25_04925	ENOG4105EA8	2-Nitropropane dioxygenase
AFK25_04930	ENOG4105WBI	UPF0223 protein
AFK25_04940	ENOG4105ECY	inositol monophosphatase
AFK25_04945	ENOG4105CI3	gtp-binding protein typa
AFK25_04950	ENOG4105QA2	
AFK25_04980	ENOG4108IAB	Phoh family
AFK25_04990	ENOG4105ZPI	UPF0358 protein
AFK25_04995	ENOG4105CNI	cell division protein FtsW
AFK25_05000	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
AFK25_05005	ENOG4105DQ6	Transposase
AFK25_05010	ENOG4107SGF	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
AFK25_05015	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
AFK25_05055	ENOG4105DQ6	Transposase
AFK25_05060	ENOG4108REF	Sporulation integral membrane protein ytvi
AFK25_05075	ENOG41080XQ	Signal transduction protein with cbs domains
AFK25_05080	ENOG4106UY4	Inherit from COG: Scp-like extracellular
AFK25_05105	ENOG4105WUC	UPF0298 protein
AFK25_05120	ENOG4106H78	methyltransferase
AFK25_05125	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
AFK25_05130	ENOG4105H20	Sporulation integral membrane protein YlbJ
AFK25_05135	ENOG4105D78	K07001 NTE family protein
AFK25_05140	ENOG41063PX	domain protein
AFK25_05145	ENOG4105CDE	UPF0348 protein
AFK25_05150	ENOG4105KNH	Nucleic acid-binding protein
AFK25_05155	ENOG41067VY	50S ribosomal protein L32
AFK25_05160	ENOG4105E39	Enoyl-CoA hydratase
AFK25_05180	ENOG41074B2	UPF0747 protein
AFK25_05185	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
AFK25_05190	ENOG41068DC	Essential cell division protein (By similarity)
AFK25_05195	ENOG4105CJN	penicillin-binding protein
AFK25_05200	ENOG4105CJN	penicillin-binding protein
AFK25_05205	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
AFK25_05210	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
AFK25_05215	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
AFK25_05220	ENOG4105CNI	cell division protein FtsW
AFK25_05225	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
AFK25_05230	ENOG4105D4A	Cell wall formation (By similarity)
AFK25_05235	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
AFK25_05240	ENOG4108R2U	division initiation protein
AFK25_05250	ENOG4105K67	small basic protein
AFK25_05255	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
AFK25_05260	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
AFK25_05265	ENOG4108AWX	Sporulation factor SpoIIGA 
AFK25_05270	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFK25_05280	ENOG4105WR5	sporulation protein, YlmC YmxH family
AFK25_05285	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
AFK25_05290	ENOG4105DFA	alanine racemase domain protein
AFK25_05295	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
AFK25_05300	ENOG41067XK	integral membrane protein
AFK25_05305	ENOG4105DBK	s4 domain protein
AFK25_05315	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
AFK25_05320	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
AFK25_05325	ENOG4105C34	Pseudouridine synthase
AFK25_05330	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
AFK25_05340	ENOG4105CXT	aspartate transcarbamylase
AFK25_05345	ENOG4105CD3	dihydroorotase
AFK25_05360	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
AFK25_05365	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
AFK25_05370	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
AFK25_05385	ENOG4105F23	Fibronectin-binding protein
AFK25_05395	ENOG4105DSJ	YicC domain protein
AFK25_05400	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
AFK25_05405	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
AFK25_05410	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
AFK25_05415	ENOG4105C25	Primosomal protein n'
AFK25_05420	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AFK25_05425	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
AFK25_05430	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
AFK25_05435	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
AFK25_05440	ENOG4108ZF3	Phosphatase
AFK25_05445	ENOG4105D9P	serine threonine protein kinase
AFK25_05450	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
AFK25_05455	ENOG4105DJV	ribulose-phosphate 3-epimerase
AFK25_05460	ENOG4105FJ0	thiamine
AFK25_05470	ENOG4105VB9	50S ribosomal protein l28
AFK25_05475	ENOG4108ZAA	Alkaline-shock protein
AFK25_05480	ENOG4105DP4	dak2 domain fusion protein ylov
AFK25_05490	ENOG4105EJQ	L-serine dehydratase
AFK25_05495	ENOG4105CB5	ATP-dependent DNA helicase recG
AFK25_05500	ENOG4108VVV	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity)
AFK25_05505	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
AFK25_05510	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
AFK25_05515	ENOG4105CHR	reductase
AFK25_05520	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
AFK25_05525	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
AFK25_05530	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
AFK25_05535	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
AFK25_05540	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
AFK25_05550	ENOG4105K5M	30s ribosomal protein S16
AFK25_05555	ENOG4105VB6	UPF0109 protein
AFK25_05565	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
AFK25_05570	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
AFK25_05575	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
AFK25_05585	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
AFK25_05590	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AFK25_05600	ENOG4105D00	flagellar biosynthetic protein flhB
AFK25_05605	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
AFK25_05610	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
AFK25_05615	ENOG4105C79	DNA protecting protein DprA
AFK25_05620	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AFK25_05625	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
AFK25_05630	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFK25_05635	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
AFK25_05640	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
AFK25_05645	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
AFK25_05650	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
AFK25_05655	ENOG4108ZC9	flagellar basal-body rod protein flgc
AFK25_05660	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
AFK25_05665	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
AFK25_05670	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
AFK25_05685	ENOG4106YF4	Flagellar biosynthesis chaperone
AFK25_05695	ENOG410696Y	Flagellar hook-length control protein
AFK25_05700	ENOG410822I	Flagellar hook capping protein
AFK25_05705	ENOG4108JQA	flagellar
AFK25_05710	ENOG41068WV	flagellar FlbD family protein
AFK25_05720	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
AFK25_05725	ENOG4105DD5	Flagellar motor switch protein
AFK25_05730	ENOG4107YTP	response regulator receiver protein
AFK25_05740	ENOG4105CN7	Flagellar biosynthetic protein FliP
AFK25_05745	ENOG4105VS8	Flagellar biosynthetic protein fliq
AFK25_05750	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
AFK25_05755	ENOG4105D00	flagellar biosynthetic protein flhB
AFK25_05760	ENOG4105D7B	Flagellar biosynthesis protein flha
AFK25_05765	ENOG4105FZW	flagellar biosynthesis regulator FlhF
AFK25_05775	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
AFK25_05780	ENOG4105CBS	Chea signal transduction histidine kinase
AFK25_05785	ENOG4108V3W	Chemotaxis protein, CheW
AFK25_05795	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
AFK25_05805	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFK25_05820	ENOG4105CE9	30S ribosomal protein S2
AFK25_05825	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
AFK25_05830	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
AFK25_05835	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
AFK25_05840	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AFK25_05845	ENOG4105KNE	Phosphatidate cytidylyltransferase
AFK25_05850	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
AFK25_05855	ENOG4105DZP	Membrane-associated zinc metalloprotease
AFK25_05860	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AFK25_05865	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
AFK25_05870	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
AFK25_05875	ENOG4105CHV	Transcription elongation factor NusA
AFK25_05880	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
AFK25_05885	ENOG4105VHM	ribosomal protein
AFK25_05890	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AFK25_05895	ENOG4105W7A	Protein of unknown function (DUF503)
AFK25_05900	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
AFK25_05905	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
AFK25_05910	ENOG4105DTN	riboflavin biosynthesis protein ribF
AFK25_05915	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
AFK25_05920	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
AFK25_05930	ENOG4105C1V	Peptidase, M16
AFK25_05940	ENOG4105E35	Dipicolinate synthase subunit A
AFK25_05945	ENOG4108S0H	Dipicolinic acid synthetase, b subunit
AFK25_05950	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
AFK25_05960	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
AFK25_05970	ENOG4105CVQ	ATP-dependent Clp protease, proteolytic subunit
AFK25_05980	ENOG4105CNU	cell division protein FtsK
AFK25_05985	ENOG4105FDP	GntR family transcriptional regulator
AFK25_05990	ENOG4105DIH	basic membrane
AFK25_05995	ENOG4108JQ9	ABC transporter
AFK25_06000	ENOG4105UIB	(ABC) transporter
AFK25_06010	ENOG4107YHD	transcriptional regulator
AFK25_06015	ENOG4105C26	Dehydrogenase
AFK25_06025	ENOG4105CK7	Sodium proline symporter
AFK25_06030	ENOG4107QQ0	gntp family
AFK25_06040	ENOG4107YZX	Universal stress protein
AFK25_06045	ENOG4105CHH	sulfate transporter
AFK25_06060	ENOG4105DWT	malate dehydrogenase (quinone)
AFK25_06075	ENOG4105C0D	helicase
AFK25_06080	ENOG4107QMH	DNA methylase
AFK25_06090	ENOG4106H3A	restriction
AFK25_06130	ENOG4105E09	nadh pyrophosphatase
AFK25_06150	ENOG4107258	Transcriptional regulator
AFK25_06155	ENOG4105P4J	Allophanate hydrolase, subunit 1
AFK25_06165	ENOG4105E7W	lamb ycsf family protein
AFK25_06180	ENOG4105D7V	transposase
AFK25_06195	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
AFK25_06200	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AFK25_06230	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
AFK25_06235	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFK25_06240	ENOG4107ZXU	DSBA oxidoreductase
AFK25_06245	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
AFK25_06255	ENOG4108NIW	Leucine export protein LeuE
AFK25_06265	ENOG4105C2U	cobyrinic Acid a,c-diamide synthase
AFK25_06295	ENOG4105C26	Dehydrogenase
AFK25_06305	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
AFK25_06310	ENOG410905X	membrane-flanked domain protein
AFK25_06315	ENOG4105CKV	Membrane
AFK25_06340	ENOG41069DP	small acid-soluble spore protein
AFK25_06345	ENOG4105DUM	transcriptional regulator, lysR family
AFK25_06350	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
AFK25_06355	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
AFK25_06360	ENOG4105K8R	UPF0145 protein
AFK25_06370	ENOG41082BM	Transcriptional regulator, arsr family
AFK25_06380	ENOG41090T1	Membrane
AFK25_06385	ENOG4107QM2	Aldo Keto reductase
AFK25_06400	ENOG41083WA	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
AFK25_06405	ENOG4105EU0	Major facilitator Superfamily
AFK25_06415	ENOG4105C2I	pirin domain protein
AFK25_06420	ENOG4108VGI	doxx family
AFK25_06425	ENOG41090MY	MarR family Transcriptional regulator
AFK25_06430	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
AFK25_06435	ENOG4105F0V	Cell wall hydrolase
AFK25_06440	ENOG4105CIG	ABC transporter
AFK25_06450	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
AFK25_06455	ENOG4105C82	Malate synthase
AFK25_06460	ENOG4105J4Q	Transcriptional regulator
AFK25_06470	ENOG4105K4I	Scp-like extracellular
AFK25_06480	ENOG4105ETD	TRANSCRIPTIONal
AFK25_06490	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
AFK25_06500	ENOG4105BZU	Histidine kinase
AFK25_06515	ENOG4105DRP	amino acid AbC transporter
AFK25_06520	ENOG4105EAD	ABC transporter
AFK25_06540	ENOG4105KK4	UPF0060 membrane protein
AFK25_06545	ENOG4105EDW	glycosyl transferase, family 39
AFK25_06550	ENOG4105CKK	Glycosyl transferase, family 2
AFK25_06575	ENOG4105U7G	Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity)
AFK25_06580	ENOG4105C84	Histidine ammonia-lyase
AFK25_06585	ENOG4105CGP	Urocanate hydratase
AFK25_06590	ENOG4105CI2	imidazolone-5-propionate hydrolase
AFK25_06595	ENOG4108903	Formimidoylglutamase
AFK25_06600	ENOG4105DQ6	Transposase
AFK25_06620	ENOG4105JAS	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity)
AFK25_06625	ENOG4107VFR	oxidoreductase
AFK25_06640	ENOG4105GPN	Uncharacterized conserved protein (DUF2294)
AFK25_06650	ENOG4108PJD	permease
AFK25_06660	ENOG4105V75	Transcriptional regulator
AFK25_06670	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AFK25_06685	ENOG4105C6T	cysteine synthase
AFK25_06700	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
AFK25_06705	ENOG4105XZV	Protein of unknown function (DUF3243)
AFK25_06720	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
AFK25_06725	ENOG4105CEV	competence damage-inducible protein
AFK25_06730	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
AFK25_06735	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
AFK25_06745	ENOG4105MCT	stage V sporulation protein S
AFK25_06750	ENOG4108IGT	Dipeptidase
AFK25_06755	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
AFK25_06760	ENOG4105DQU	oxidoreductase, subunit beta
AFK25_06765	ENOG4105DQ6	Transposase
AFK25_06770	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AFK25_06785	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
AFK25_06790	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
AFK25_06795	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
AFK25_06800	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
AFK25_06805	ENOG4106F1P	AAA ATPase, central domain protein
AFK25_06820	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
AFK25_06825	ENOG4105CEY	Amp-dependent synthetase and ligase
AFK25_06830	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
AFK25_06835	ENOG4105CHU	acetyl-coa acetyltransferase
AFK25_06840	ENOG4105EN6	Membrane
AFK25_06845	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
AFK25_06850	ENOG4105CXI	aluminum resistance protein
AFK25_06855	ENOG4105KV4	Transcriptional regulator
AFK25_06860	ENOG4105C5F	glutamine synthetase
AFK25_06865	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
AFK25_06875	ENOG4108SVB	resolvase
AFK25_06880	ENOG4105VPS	UPF0291 protein
AFK25_06890	ENOG4105VXM	UPF0154 protein
AFK25_06895	ENOG4107QIV	Cytochrome c biogenesis protein
AFK25_06900	ENOG4107YTP	response regulator receiver protein
AFK25_06915	ENOG4107DZX	Small, acid-soluble spore protein P
AFK25_06925	ENOG410746C	Acid-soluble spore protein O
AFK25_06930	ENOG4108I0Z	Aconitate hydratase
AFK25_06980	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
AFK25_06985	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
AFK25_06990	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
AFK25_07000	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
AFK25_07005	ENOG4105E98	transcriptional regulator DeoR family
AFK25_07010	ENOG4105DE4	1-phosphofructokinase
AFK25_07015	ENOG4105DM4	PTS System
AFK25_07020	ENOG4105NQC	Flavodoxin
AFK25_07025	ENOG4105BZU	Histidine kinase
AFK25_07030	ENOG4105EXQ	uroporphyrinogen iii synthase hem4
AFK25_07035	ENOG4105C8Q	Methyl-accepting chemotaxis
AFK25_07045	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
AFK25_07070	ENOG4105CVG	Homoserine O-transsuccinylase
AFK25_07075	ENOG4108Y6J	UPF0403 protein
AFK25_07080	ENOG4107YX5	Pfam:DUF548
AFK25_07095	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
AFK25_07100	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
AFK25_07105	ENOG4105E3S	small subunit
AFK25_07110	ENOG4105DPX	Hydrogenase, large subunit
AFK25_07120	ENOG4108USZ	hydrogenase
AFK25_07130	ENOG41082RJ	Hydrogenase nickel insertion protein HypA
AFK25_07135	ENOG4107RSS	Hydrogenase accessory protein HypB
AFK25_07145	ENOG41083WG	hydrogenase assembly chaperone
AFK25_07150	ENOG4105CQS	hydrogenase expression formation protein HypD
AFK25_07155	ENOG4105C45	hydrogenase expression formation protein (HypE)
AFK25_07160	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
AFK25_07165	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
AFK25_07170	ENOG4105C7B	Threonine dehydratase
AFK25_07185	ENOG4108KF3	Electron transport protein SCO1 SenC
AFK25_07190	ENOG41090WU	lipolytic protein G-D-S-L family
AFK25_07200	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
AFK25_07205	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
AFK25_07210	ENOG4105K4P	CoA-binding domain protein
AFK25_07215	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AFK25_07230	ENOG4105C5Y	PTS System
AFK25_07235	ENOG4105CG3	alpha amylase, catalytic region
AFK25_07240	ENOG4107414	GntR family transcriptional regulator
AFK25_07245	ENOG4105WDJ	50S ribosomal protein L33
AFK25_07250	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
AFK25_07255	ENOG4108QTI	)-transporter
AFK25_07260	ENOG4105CIY	formyltetrahydrofolate deformylase
AFK25_07270	ENOG4105XTG	Pfam:DUF156
AFK25_07275	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
AFK25_07280	ENOG4107T89	von Willebrand factor, type A
AFK25_07305	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AFK25_07335	ENOG4105IJJ	transcriptional regulator, crp fnr family
AFK25_07370	ENOG4105VNH	ABC transporter solute-binding protein
AFK25_07415	ENOG4105DKW	ABC transporter
AFK25_07425	ENOG4105E1F	short-chain dehydrogenase reductase
AFK25_07435	ENOG4108PCN	EamA-like transporter family
AFK25_07440	ENOG4108UXE	Protein tyrosine phosphatase
AFK25_07445	ENOG4107R5R	arsenical pump membrane protein
AFK25_07450	ENOG41082YX	Transcriptional regulator, arsr family
AFK25_07455	ENOG4107QRP	cobalamin biosynthesis protein CobW
AFK25_07460	ENOG4108B1Q	Ribonuclease
AFK25_07480	ENOG4108TU7	Inherit from COG: (ABC) transporter
AFK25_07485	ENOG4105CJ1	ABC, transporter
AFK25_07490	ENOG41090WU	lipolytic protein G-D-S-L family
AFK25_07500	ENOG4105VEQ	Cold shock protein
AFK25_07510	ENOG4105CFP	Peptidase U32
AFK25_07520	ENOG4105DVE	abc transporter atp-binding protein
AFK25_07525	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
AFK25_07545	ENOG4105C7B	Threonine dehydratase
AFK25_07550	ENOG4105WEF	catalase
AFK25_07560	ENOG4105BZU	Histidine kinase
AFK25_07570	ENOG4107QMU	Mate efflux family protein
AFK25_07575	ENOG4105FR1	rard protein
AFK25_07595	ENOG4108VXD	carboxy-peptidase
AFK25_07610	ENOG4106Z5R	
AFK25_07615	ENOG4108N23	SpoOM-related protein
AFK25_07625	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
AFK25_07645	ENOG4105W8X	HesB YadR YfhF-family protein
AFK25_07655	ENOG41067CD	Small, acid-soluble spore protein Tlp
AFK25_07660	ENOG41075ZD	Small, acid-soluble spore protein N
AFK25_07670	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFK25_07680	ENOG410890F	Dynamin family
AFK25_07690	ENOG41065KQ	synthase
AFK25_07705	ENOG4105NAA	Cytochrome C oxidase, subunit II
AFK25_07710	ENOG4107RQ2	Cytochrome c oxidase, subunit I
AFK25_07715	ENOG4105CTD	carboxy-peptidase
AFK25_07720	ENOG4105DVT	helicase
AFK25_07725	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
AFK25_07730	ENOG4105BZU	Histidine kinase
AFK25_07735	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
AFK25_07745	ENOG4106YBV	Methyl-accepting chemotaxis
AFK25_07765	ENOG4108MJI	response regulator
AFK25_07770	ENOG4105CGU	Enoyl-CoA hydratase
AFK25_07775	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
AFK25_07780	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
AFK25_07785	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
AFK25_07805	ENOG4107Y9E	nuclease
AFK25_07810	ENOG4105CVJ	phosphoglycerate mutase
AFK25_07815	ENOG4105CJ1	ABC, transporter
AFK25_07835	ENOG4105BZU	Histidine kinase
AFK25_07845	ENOG4105KTU	Transcriptional regulator, arsr family
AFK25_07850	ENOG4105DVT	helicase
AFK25_07875	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
AFK25_07880	ENOG4105EJ5	oxidoreductase gamma subunit
AFK25_07890	ENOG4105BZ1	(ABC) transporter
AFK25_07895	ENOG4105BZ1	(ABC) transporter
AFK25_07905	ENOG4107SBE	Glycosyl transferase (Group 1
AFK25_07910	ENOG4108KS4	Spore coat protein
AFK25_07915	ENOG4108V06	Glutathione peroxidase
AFK25_07920	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
AFK25_07945	ENOG4105DTQ	mandelate racemase muconate lactonizing
AFK25_07950	ENOG4108HWW	ABC transporter
AFK25_07955	ENOG4105C2J	ABC transporter
AFK25_07960	ENOG4105DFW	ABC transporter
AFK25_07965	ENOG4108VAC	response regulator
AFK25_07970	ENOG4105C2F	Histidine kinase
AFK25_07980	ENOG4105C8Q	Methyl-accepting chemotaxis
AFK25_08010	ENOG4105CDW	Resistance protein
AFK25_08035	ENOG4105CC5	ABC transporter
AFK25_08040	ENOG4105CC5	ABC transporter
AFK25_08045	ENOG4105DIK	(ABC) transporter
AFK25_08050	ENOG4105DSE	periplasmic solute binding protein
AFK25_08055	ENOG4107R7I	amino acid
AFK25_08065	ENOG4105DWD	nucleoside recognition domain protein
AFK25_08090	ENOG4108UT2	hemolysin iii
AFK25_08095	ENOG4105CSU	acyl-Coa dehydrogenase
AFK25_08100	ENOG4105CEY	Amp-dependent synthetase and ligase
AFK25_08110	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
AFK25_08125	ENOG4105RHA	ABC transporter, permease
AFK25_08130	ENOG4108IUX	(ABC) transporter
AFK25_08140	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AFK25_08145	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
AFK25_08155	ENOG4105E0A	ABC, transporter
AFK25_08160	ENOG4108IHU	transport system permease protein
AFK25_08165	ENOG4105DQ5	transport system permease protein
AFK25_08170	ENOG4108MES	Periplasmic binding protein
AFK25_08180	ENOG4108PSK	reductase
AFK25_08260	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
AFK25_08265	ENOG4105C10	Electron transfer flavoprotein
AFK25_08270	ENOG4105BZJ	Electron transfer flavoprotein
AFK25_08280	ENOG4105C26	Dehydrogenase
AFK25_08290	ENOG4107QTZ	amino acid
AFK25_08300	ENOG4108JPW	Aminotransferase
AFK25_08310	ENOG4105C1G	acyl-Coa dehydrogenase
AFK25_08320	ENOG4105C01	Dihydroxy-acid dehydratase
AFK25_08325	ENOG4105BZ8	glutamate synthase
AFK25_08330	ENOG4105CBC	glutamate synthase
AFK25_08335	ENOG4105C5Q	Transcriptional regulator
AFK25_08340	ENOG4108NVR	Methyl-accepting chemotaxis
AFK25_08365	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
AFK25_08380	ENOG4105CAQ	asparagine synthetase
AFK25_08385	ENOG4107R16	Multicopper oxidase
AFK25_08395	ENOG4105C59	p-type ATPase
AFK25_08400	ENOG4105VPX	protein, conserved in bacteria
AFK25_08425	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AFK25_08430	ENOG4105BZU	Histidine kinase
AFK25_08450	ENOG4108HKT	sucrose-6-phosphate hydrolase
AFK25_08470	ENOG4105CV8	reductase
AFK25_08480	ENOG4108UW5	maltose o-acetyltransferase
AFK25_08485	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
AFK25_08500	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
AFK25_08530	ENOG4105CN9	Peptidase m42 family protein
AFK25_08540	ENOG4105C4R	Atp-dependent dna helicase
AFK25_08555	ENOG4105CFI	type iii restriction protein res subunit
AFK25_08585	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
AFK25_08590	ENOG41082K6	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
AFK25_08595	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
AFK25_08600	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
AFK25_08605	ENOG4105EHG	Permease protein
AFK25_08610	ENOG4105DQ5	transport system permease protein
AFK25_08620	ENOG4105E0A	ABC, transporter
AFK25_08625	ENOG4105BZU	Histidine kinase
AFK25_08630	ENOG4106YBV	Methyl-accepting chemotaxis
AFK25_08635	ENOG4105BZW	Glycerate kinase
AFK25_08665	ENOG4105MYT	Heat shock protein
AFK25_08670	ENOG4105EU9	
AFK25_08675	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
AFK25_08700	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
AFK25_08705	ENOG4105BZ4	penicillin-binding protein
AFK25_08715	ENOG4105CSM	endonuclease III
AFK25_08725	ENOG4105C5S	asparaginyl-tRNA synthetase
AFK25_08765	ENOG4105DVT	helicase
AFK25_08770	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
AFK25_08775	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
AFK25_08780	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
AFK25_08790	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AFK25_08795	ENOG4105CPK	Glycosyl transferase (Group 1
AFK25_08800	ENOG4105FJR	Lmbe family
AFK25_08805	ENOG4108Z5K	methylglyoxal synthase
AFK25_08810	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
AFK25_08815	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
AFK25_08820	ENOG4108JYZ	YitT family
AFK25_08835	ENOG4105PE6	Menaquinol-cytochrome c reductase, cytochrome b c subunit
AFK25_08840	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
AFK25_08845	ENOG4105DQV	Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity)
AFK25_08855	ENOG4108SXZ	UPF0302 protein
AFK25_08860	ENOG41068YB	TPR repeat-containing protein
AFK25_08865	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
AFK25_08875	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AFK25_08880	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
AFK25_08885	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
AFK25_08890	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
AFK25_08895	ENOG4105DK0	Indole-3-glycerol phosphate synthase
AFK25_08900	ENOG4108I0Q	anthranilate phosphoribosyltransferase
AFK25_08910	ENOG4105KHN	chorismate mutase
AFK25_08915	ENOG4105D49	3-dehydroquinate synthase
AFK25_08920	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
AFK25_08925	ENOG4105BZU	Histidine kinase
AFK25_08930	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
AFK25_08940	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AFK25_08950	ENOG4105WP2	Tryptophan RNA-binding attenuator protein
AFK25_08955	ENOG4105EUJ	GTP cyclohydrolase i
AFK25_08965	ENOG4105DXU	ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity)
AFK25_08980	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AFK25_08985	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
AFK25_08990	ENOG41065D1	
AFK25_08995	ENOG4105S2F	
AFK25_09005	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
AFK25_09010	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
AFK25_09020	ENOG4105CAT	Cytidine monophosphate kinase
AFK25_09035	ENOG4108PNU	Involved in the degradation of specific anti-sigma factors (By similarity)
AFK25_09040	ENOG4105F0V	Cell wall hydrolase
AFK25_09045	ENOG4105MSI	germination protein ypeb
AFK25_09050	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
AFK25_09055	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
AFK25_09060	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
AFK25_09075	ENOG4108S6Z	Negative regulator of genetic competence
AFK25_09080	ENOG4108XDN	Transcriptional regulator
AFK25_09085	ENOG4107RGJ	metallophosphoesterase
AFK25_09105	ENOG4105WEF	catalase
AFK25_09120	ENOG4105I7S	Abortive infection protein
AFK25_09125	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AFK25_09130	ENOG4105T7X	
AFK25_09145	ENOG4108JQ1	Dehydrogenase
AFK25_09150	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
AFK25_09165	ENOG4108WBT	adenosyltransferase
AFK25_09180	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
AFK25_09195	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
AFK25_09200	ENOG4105E0A	ABC, transporter
AFK25_09205	ENOG4105EHG	Permease protein
AFK25_09210	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
AFK25_09215	ENOG4105BZU	Histidine kinase
AFK25_09220	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AFK25_09225	ENOG4105CRE	cytochrome C
AFK25_09230	ENOG4107TWT	Cytochrome c biogenesis protein
AFK25_09235	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFK25_09240	ENOG4105FE9	pseudouridine synthase
AFK25_09250	ENOG4108JIC	nucleoside recognition domain protein
AFK25_09255	ENOG4105DZ1	carboxypeptidase
AFK25_09260	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
AFK25_09280	ENOG4105W1Y	Transcriptional regulator
AFK25_09285	ENOG41082BM	Transcriptional regulator, arsr family
AFK25_09315	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
AFK25_09320	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
AFK25_09335	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
AFK25_09340	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
AFK25_09345	ENOG4108R6K	riboflavin synthase, subunit alpha
AFK25_09350	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
AFK25_09355	ENOG4107ZE5	PPIases accelerate the folding of proteins
AFK25_09360	ENOG4105PTM	secreted protein
AFK25_09365	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
AFK25_09375	ENOG4105G6R	Stage v sporulation protein ae
AFK25_09385	ENOG4105CZ3	stage V sporulation protein ad
AFK25_09405	ENOG4105CT2	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFK25_09410	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
AFK25_09415	ENOG41082AN	stage II sporulation protein
AFK25_09420	ENOG4105DZ1	carboxypeptidase
AFK25_09440	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFK25_09450	ENOG4105I3K	Ferric uptake regulator, Fur family
AFK25_09455	ENOG4105MZ9	stage II sporulation protein m
AFK25_09460	ENOG4108YZ4	nudix hydrolase
AFK25_09465	ENOG4105CPC	Aldo Keto reductase
AFK25_09485	ENOG4105R3A	Nitrate reductase
AFK25_09490	ENOG4108IUE	nitrate reductase beta subunit
AFK25_09505	ENOG4107V6Q	Cyclic nucleotide-binding domain
AFK25_09510	ENOG4105D06	uba thif-type nad fad binding protein
AFK25_09515	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AFK25_09525	ENOG4108ZAF	Molybdopterin
AFK25_09530	ENOG4108129	molybdopterin-guanine dinucleotide biosynthesis protein
AFK25_09535	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
AFK25_09545	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
AFK25_09550	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AFK25_09555	ENOG4108IJ6	ABC transporter
AFK25_09560	ENOG4105E0C	molybdate abc transporter
AFK25_09565	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
AFK25_09570	ENOG4107QND	Nitrite extrusion protein
AFK25_09580	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
AFK25_09590	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFK25_09595	ENOG41060IM	Heme exporter protein
AFK25_09605	ENOG4105CJ1	ABC, transporter
AFK25_09615	ENOG4105DA4	cytochrome c-type biogenesis protein
AFK25_09635	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
AFK25_09655	ENOG4108IXY	short-chain dehydrogenase reductase
AFK25_09660	ENOG41069FQ	Metallo-beta-lactamase superfamily
AFK25_09665	ENOG4105II7	pyrroline-5-carboxylate reductase
AFK25_09670	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
AFK25_09680	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
AFK25_09685	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
AFK25_09690	ENOG4107XCH	Cyclase family
AFK25_09695	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
AFK25_09700	ENOG4108V3W	Chemotaxis protein, CheW
AFK25_09705	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
AFK25_09710	ENOG4108HNZ	carboxyl transferase
AFK25_09715	ENOG4108ZVT	methylmalonyl-coA epimerase
AFK25_09720	ENOG4108VZI	ErfK ybiS ycfS ynhG family protein
AFK25_09725	ENOG4108QEG	Membrane
AFK25_09735	ENOG4105D5P	Methylmalonyl-coA mutase
AFK25_09740	ENOG4105CMN	Methylmalonyl-coA mutase
AFK25_09745	ENOG4105C7S	Dehydrogenase
AFK25_09750	ENOG4105CPP	Dehydrogenase, E1 component
AFK25_09765	ENOG4105CKM	Branched-chain carboxylic acid kinase
AFK25_09780	ENOG4108JUB	Transcriptional regulator
AFK25_09785	ENOG4106CCJ	Protein of unknown function (DUF2627)
AFK25_09790	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
AFK25_09800	ENOG4105S1Z	Stage IV sporulation protein B
AFK25_09805	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
AFK25_09815	ENOG4105DX0	Hemolysin A
AFK25_09820	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
AFK25_09830	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
AFK25_09835	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
AFK25_09840	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AFK25_09845	ENOG4105M7K	Involved in the transcription termination process (By similarity)
AFK25_09850	ENOG4108ZSR	alkaline shock protein
AFK25_09855	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
AFK25_09875	ENOG410644B	Stage III sporulation protein af
AFK25_09885	ENOG4105KQ4	Stage iii sporulation protein ad
AFK25_09890	ENOG4108CQH	stage III sporulation protein AC
AFK25_09895	ENOG4105KR5	Stage iii sporulation protein
AFK25_09900	ENOG4105CD2	stage iii sporulation protein aa
AFK25_09910	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
AFK25_09915	ENOG4105DC7	peptidase M24
AFK25_09920	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
AFK25_09930	ENOG4105CBJ	Metal-dependent enzyme
AFK25_09945	ENOG4105KST	dependent repressor
AFK25_09955	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AFK25_09960	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
AFK25_09965	ENOG4105WZW	rhodanese family
AFK25_09970	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFK25_09975	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFK25_09980	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
AFK25_09985	ENOG4105C0D	helicase
AFK25_10025	ENOG4106855	Competence protein
AFK25_10060	ENOG4105C5X	domain protein
AFK25_10075	ENOG4105E0M	Sulfatase
AFK25_10080	ENOG4105DKQ	ROK family
AFK25_10100	ENOG4107ZXI	Rhomboid family
AFK25_10110	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
AFK25_10115	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
AFK25_10120	ENOG4105WDJ	50S ribosomal protein L33
AFK25_10140	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
AFK25_10145	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
AFK25_10150	ENOG4105E2Z	phosphate ABC transporter (Permease
AFK25_10155	ENOG4105C8U	phosphate abc transporter
AFK25_10160	ENOG4105EXS	phosphate abc transporter
AFK25_10165	ENOG4107RF6	penicillin-binding protein
AFK25_10190	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
AFK25_10200	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
AFK25_10205	ENOG41063Y9	
AFK25_10210	ENOG4108U5J	'-nucleotidase
AFK25_10215	ENOG4105N80	Ferric uptake regulator, Fur family
AFK25_10220	ENOG4105FAV	ABC, transporter
AFK25_10225	ENOG4105FDK	ABC transporter
AFK25_10230	ENOG4108JYZ	YitT family
AFK25_10240	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
AFK25_10255	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
AFK25_10260	ENOG4105EGD	dinuclear metal center protein, YbgI family
AFK25_10280	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFK25_10290	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
AFK25_10300	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
AFK25_10305	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
AFK25_10310	ENOG4107YR5	Diacylglycerol kinase
AFK25_10315	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
AFK25_10320	ENOG4105C9A	Phoh family
AFK25_10330	ENOG41068P3	sporulation protein YqfC
AFK25_10340	ENOG4105DI5	UPF0365 protein
AFK25_10345	ENOG4105F7J	membrane-bound serine protease
AFK25_10350	ENOG4105KTH	gatB Yqey
AFK25_10355	ENOG4105VCC	30S ribosomal protein S21
AFK25_10360	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AFK25_10365	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
AFK25_10370	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
AFK25_10375	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AFK25_10380	ENOG4105CFG	Acts as a chaperone (By similarity)
AFK25_10385	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFK25_10390	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
AFK25_10395	ENOG4105CSA	Coproporphyrinogen iii oxidase
AFK25_10400	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AFK25_10410	ENOG4108ZRV	stage ii sporulation protein p
AFK25_10415	ENOG4105CEF	Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity)
AFK25_10420	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
AFK25_10425	ENOG4105IJJ	transcriptional regulator, crp fnr family
AFK25_10430	ENOG4105TQK	DNA polymerase iii, delta' subunit
AFK25_10440	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
AFK25_10445	ENOG4108UK2	deaminase
AFK25_10450	ENOG4105KQC	Competence protein
AFK25_10460	ENOG4105DXX	methyltransferase
AFK25_10470	ENOG4108WF2	Metal Dependent Phosphohydrolase
AFK25_10475	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
AFK25_10480	ENOG410812S	Rna-binding protein
AFK25_10485	ENOG4105E2X	shikimate dehydrogenase
AFK25_10490	ENOG4105CQW	ribosome biogenesis GTPase YqeH
AFK25_10495	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
AFK25_10505	ENOG4105DJ4	phosphatidylserine decarboxylase
AFK25_10510	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
AFK25_10515	ENOG4105E14	MotA TolQ exbB proton channel
AFK25_10520	ENOG4105ER2	Ompa motb domain protein
AFK25_10525	ENOG4105CZN	Potassium uptake protein
AFK25_10530	ENOG4105DMD	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFK25_10540	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
AFK25_10605	ENOG4105C28	cystathionine
AFK25_10615	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
AFK25_10620	ENOG4108WVK	Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
AFK25_10635	ENOG4107XRG	penicillin-binding protein
AFK25_10640	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
AFK25_10645	ENOG4105DBI	uridine monophosphokinase
AFK25_10650	ENOG4105CFP	Peptidase U32
AFK25_10655	ENOG4105XYU	peptidase (U32 family)
AFK25_10660	ENOG4108VQJ	O-methyltransferase
AFK25_10665	ENOG4105HHA	aminodeoxychorismate lyase
AFK25_10670	ENOG4105VPH	UPF0473 protein
AFK25_10675	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
AFK25_10680	ENOG4105VBH	UPF0297 protein
AFK25_10685	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AFK25_10690	ENOG4105C02	permease
AFK25_10695	ENOG41060CR	
AFK25_10700	ENOG4105C7H	Helicase, RecD TraA family
AFK25_10710	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
AFK25_10715	ENOG4105C3J	Cysteine desulfurase
AFK25_10725	ENOG4105D1H	recombination factor protein RarA
AFK25_10730	ENOG41067SE	Tetr family transcriptional regulator
AFK25_10740	ENOG4105CUZ	uba thif-type nad fad binding protein
AFK25_10745	ENOG4105C9M	aspartyl-trna synthetase
AFK25_10750	ENOG4105CUT	histidyl-tRNA synthetase
AFK25_10755	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
AFK25_10765	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
AFK25_10770	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AFK25_10775	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
AFK25_10780	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
AFK25_10785	ENOG41076HS	cation diffusion facilitator family transporter
AFK25_10790	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AFK25_10800	ENOG4105CKP	Polysaccharide Biosynthesis Protein
AFK25_10805	ENOG4108QG2	Membrane
AFK25_10810	ENOG4105NAP	
AFK25_10815	ENOG4105VIE	preprotein translocase, subunit YajC
AFK25_10820	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
AFK25_10825	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
AFK25_10830	ENOG41061AI	Protein of unknown function (DUF2905)
AFK25_10835	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
AFK25_10840	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
AFK25_10850	ENOG4105CDY	transcriptional regulatory protein
AFK25_10860	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
AFK25_10865	ENOG4105DQ6	Transposase
AFK25_10870	ENOG4106678	morphogenetic protein associated with SpoVID
AFK25_10875	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
AFK25_10880	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
AFK25_10885	ENOG4108IYU	L-aspartate oxidase
AFK25_10900	ENOG4105CQC	Prephenate dehydratase
AFK25_10905	ENOG41090I5	UPF0735 ACT domain-containing protein
AFK25_10910	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFK25_10920	ENOG4105K46	50S ribosomal protein l27
AFK25_10925	ENOG4105X36	(ribosomal) protein
AFK25_10930	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
AFK25_10945	ENOG4107QMS	site-determining protein
AFK25_10950	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
AFK25_10960	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
AFK25_10965	ENOG4105DFF	Rod shape-determining protein mreb
AFK25_10970	ENOG4105W5Q	DNA repair protein (RadC
AFK25_11005	ENOG4106A3R	peptidase
AFK25_11020	ENOG4105CZX	twitching motility protein
AFK25_11025	ENOG4107QHF	type ii secretion system protein e
AFK25_11070	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
AFK25_11075	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
AFK25_11085	ENOG4106AR7	Spore coat protein
AFK25_11090	ENOG41068KH	stage VI sporulation protein D
AFK25_11090	ENOG41068KH	stage VI sporulation protein D
AFK25_11095	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
AFK25_11100	ENOG4105D52	delta-aminolevulinic acid dehydratase
AFK25_11110	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
AFK25_11120	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
AFK25_11130	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
AFK25_11140	ENOG4108IUQ	atp-dependent protease
AFK25_11145	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
AFK25_11150	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
AFK25_11160	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AFK25_11165	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AFK25_11170	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
AFK25_11175	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AFK25_11180	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
AFK25_11185	ENOG4108ZP8	Acetolactate synthase small subunit
AFK25_11190	ENOG4105C7K	acetolactate synthase
AFK25_11195	ENOG4105CM2	brancheD-chain amino acid aminotransferase
AFK25_11205	ENOG4105M59	Phosphodiesterase, mj0936 family
AFK25_11210	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
AFK25_11215	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
AFK25_11220	ENOG4108XJQ	germination protein
AFK25_11225	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
AFK25_11230	ENOG4105PFC	Transcriptional regulator
AFK25_11240	ENOG4105E33	succinate dehydrogenase
AFK25_11250	ENOG4108NU2	Succinate dehydrogenase cytochrome b558 subunit
AFK25_11260	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
AFK25_11280	ENOG4105C3Q	Glycosyl transferase, family 2
AFK25_11305	ENOG4105K63	Thioredoxin
AFK25_11310	ENOG4105C10	Electron transfer flavoprotein
AFK25_11315	ENOG4105BZJ	Electron transfer flavoprotein
AFK25_11320	ENOG41060WC	Enoyl-CoA hydratase
AFK25_11325	ENOG4107Z3H	Transcriptional regulator, TetR family
AFK25_11330	ENOG4105CEY	Amp-dependent synthetase and ligase
AFK25_11340	ENOG4105C98	muts2 protein
AFK25_11345	ENOG4105DCG	PHP domain protein
AFK25_11355	ENOG410687F	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
AFK25_11360	ENOG4105EYF	MMPL domain protein
AFK25_11370	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
AFK25_11375	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
AFK25_11380	ENOG4108RWN	rrna methyltransferase
AFK25_11385	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
AFK25_11390	ENOG41067MF	small acid-soluble spore protein
AFK25_11395	ENOG4105CMG	Carbohydrate kinase
AFK25_11405	ENOG4105MU9	integral membrane protein
AFK25_11420	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
AFK25_11425	ENOG4105XN3	extracellular solute-binding protein family 1
AFK25_11430	ENOG41075H3	AraC family transcriptional regulator
AFK25_11435	ENOG4105C2F	Histidine kinase
AFK25_11445	ENOG4105CPC	Aldo Keto reductase
AFK25_11450	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
AFK25_11470	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
AFK25_11475	ENOG4105CMR	udp-glucose 4-epimerase
AFK25_11480	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
AFK25_11505	ENOG4105CN9	Peptidase m42 family protein
AFK25_11515	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
AFK25_11520	ENOG4105VJV	50s ribosomal protein L35
AFK25_11530	ENOG4105C22	threonyL-tRNA synthetase
AFK25_11535	ENOG4108TDW	sporulation protein YtxC
AFK25_11550	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
AFK25_11560	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
AFK25_11565	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
AFK25_11580	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
AFK25_11590	ENOG4105BZU	Histidine kinase
AFK25_11595	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
AFK25_11605	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
AFK25_11610	ENOG4108HMX	isocitrate dehydrogenase (NADP)
AFK25_11615	ENOG4105BZN	citrate synthase
AFK25_11620	ENOG4108VMM	UPF0756 membrane protein
AFK25_11625	ENOG4108REF	Sporulation integral membrane protein ytvi
AFK25_11630	ENOG4105FS0	cytoplasmic membrane protein
AFK25_11640	ENOG4105CTQ	phosphohexokinase
AFK25_11645	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
AFK25_11650	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
AFK25_11655	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
AFK25_11660	ENOG4105C6K	Malic enzyme
AFK25_11665	ENOG4105C0B	DNA polymerase III (alpha subunit)
AFK25_11670	ENOG4105VV2	
AFK25_11680	ENOG4105SFS	phosphoesterase RecJ domain protein
AFK25_11695	ENOG4105E8R	UPF0173 metal-dependent hydrolase
AFK25_11700	ENOG4105DC7	peptidase M24
AFK25_11710	ENOG4107YZX	Universal stress protein
AFK25_11715	ENOG4105CH7	arginosuccinase
AFK25_11720	ENOG4105CDH	Citrulline--aspartate ligase
AFK25_11730	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
AFK25_11740	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
AFK25_11745	ENOG4105KBJ	sporulation protein ytfj
AFK25_11755	ENOG4108KKH	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
AFK25_11765	ENOG4108IV0	ABC, transporter
AFK25_11770	ENOG4105CP9	extracellular ligand-binding receptor
AFK25_11780	ENOG4105C32	Amino acid ABC transporter (Permease)
AFK25_11790	ENOG4105C0Z	ABC transporter
AFK25_11795	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
AFK25_11805	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
AFK25_11820	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
AFK25_11825	ENOG4108W76	histidinol phosphate phosphatase hisj family
AFK25_11835	ENOG4105BZU	Histidine kinase
AFK25_11840	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
AFK25_11860	ENOG4105F1V	Acetoin utilization protein
AFK25_11865	ENOG4105W87	Cbs domain
AFK25_11870	ENOG4105DGU	Histone deacetylase
AFK25_11875	ENOG4105ETE	Transcriptional regulator (LacI family
AFK25_11880	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
AFK25_11885	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
AFK25_11890	ENOG4105C88	aminopeptidase
AFK25_11910	ENOG4105DFU	Cell wall formation (By similarity)
AFK25_11925	ENOG4108VDD	TRNA binding domain protein
AFK25_11930	ENOG4108NKM	UPF0354 protein
AFK25_11955	ENOG4105C8F	Beta-lactamase domain protein
AFK25_11960	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
AFK25_11970	ENOG4108V15	phosphotransferase enzyme family
AFK25_11975	ENOG4108IUM	Glycogen debranching enzyme
AFK25_11990	ENOG41067MG	lrgb family
AFK25_11995	ENOG4105VAW	lrga family
AFK25_12010	ENOG4107QSE	Dipeptidase
AFK25_12015	ENOG4105YW5	deoR family transcriptional regulator
AFK25_12035	ENOG4105CBX	hi0933 family
AFK25_12040	ENOG41085GJ	domain protein
AFK25_12045	ENOG4105C8T	Leucyl-tRNA synthetase
AFK25_12055	ENOG4105N5T	Radical SAM Protein
AFK25_12075	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
AFK25_12080	ENOG4108Z0R	Transferase
AFK25_12085	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
AFK25_12090	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
AFK25_12095	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
AFK25_12130	ENOG4105G01	cobalamin (vitamin B12) biosynthesis CbiM protein
AFK25_12135	ENOG4108V4M	Cobalt abc transporter
AFK25_12140	ENOG4108JJB	ABC transporter
AFK25_12155	ENOG4105D2X	ABC transporter substrate-binding protein
AFK25_12165	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
AFK25_12180	ENOG4108RMU	ferritin dps family protein
AFK25_12185	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
AFK25_12190	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
AFK25_12195	ENOG4105CKI	cobalamin synthesis protein
AFK25_12200	ENOG4105DSE	periplasmic solute binding protein
AFK25_12215	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AFK25_12220	ENOG4105NQC	Flavodoxin
AFK25_12225	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AFK25_12250	ENOG4105C4M	(Ubiquinol oxidase) subunit I
AFK25_12255	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
AFK25_12260	ENOG4105CEY	Amp-dependent synthetase and ligase
AFK25_12265	ENOG4108IPT	Naphthoate synthase
AFK25_12270	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
AFK25_12275	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
AFK25_12280	ENOG4105E4F	Isochorismate synthase
AFK25_12285	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
AFK25_12300	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
AFK25_12310	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
AFK25_12320	ENOG4105PGM	cation diffusion facilitator family transporter
AFK25_12400	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
AFK25_12455	ENOG4105KT7	mgtC SapB transporter
AFK25_12470	ENOG4106GRI	small acid-soluble spore protein H
AFK25_12475	ENOG4107PBV	potassium channel
AFK25_12490	ENOG4107QW4	alcohol dehydrogenase
AFK25_12495	ENOG4105WG9	Conserved Protein
AFK25_12510	ENOG4105CHM	Aminotransferase
AFK25_12515	ENOG4108ZB6	transcriptional regulator AsnC family
AFK25_12520	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
AFK25_12550	ENOG41069ER	domain protein
AFK25_12560	ENOG4105CEP	NADH dehydrogenase
AFK25_12565	ENOG4105CAY	ferredoxin--nadp reductase
AFK25_12570	ENOG4105DQ6	Transposase
AFK25_12575	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
AFK25_12580	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
AFK25_12610	ENOG41083MR	nifu domain-containing protein
AFK25_12615	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
AFK25_12620	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
AFK25_12625	ENOG4105D6E	homoserine dehydrogenase
AFK25_12630	ENOG4105C5I	Dehydrogenase
AFK25_12640	ENOG4108W5N	phosphatidylglycerophosphatase a
AFK25_12645	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
AFK25_12670	ENOG4105MMD	transcriptional regulator
AFK25_12675	ENOG4106EGE	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
AFK25_12680	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
AFK25_12685	ENOG4105FAA	peptidase M23
AFK25_12690	ENOG4105C8J	)-transporter
AFK25_12695	ENOG4108YTE	sporulation protein YunB
AFK25_12700	ENOG4105KZD	Domain of unknown function (DUF1805)
AFK25_12705	ENOG4107R8B	5'-nucleotidase
AFK25_12715	ENOG4105I3N	Conserved Protein
AFK25_12720	ENOG4105DIW	FeS assembly protein SUFB
AFK25_12725	ENOG4108UNV	SUF system FeS assembly protein, NifU family
AFK25_12735	ENOG4105JRK	feS assembly protein SufD
AFK25_12740	ENOG4105C3K	feS assembly ATPase SufC
AFK25_12750	ENOG4105D01	(LipO)protein
AFK25_12755	ENOG4108UMI	ABC transporter, permease
AFK25_12760	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
AFK25_12790	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
AFK25_12795	ENOG41080E8	Transcriptional regulator, Spx MgsR family
AFK25_12800	ENOG4105C1G	acyl-Coa dehydrogenase
AFK25_12805	ENOG4105CHU	acetyl-coa acetyltransferase
AFK25_12840	ENOG4108WHG	pyridoxamine 5'-phosphate
AFK25_12850	ENOG4105EHG	Permease protein
AFK25_12855	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
AFK25_12860	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
AFK25_12865	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
AFK25_12875	ENOG4105XZU	Preprotein translocase, subunit SecG
AFK25_12880	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AFK25_12895	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AFK25_12900	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
AFK25_12905	ENOG4105CP7	Triose-phosphate isomerase
AFK25_12910	ENOG4105BZA	Phosphoglycerate kinase
AFK25_12930	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFK25_12940	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AFK25_12945	ENOG4105KRI	phosphocarrier protein (HPr
AFK25_12950	ENOG4105CIE	May be required for sporulation (By similarity)
AFK25_12955	ENOG4105CHW	UPF0052 protein
AFK25_12960	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
AFK25_12965	ENOG4108Z4K	mutator MutT protein
AFK25_12970	ENOG4105C3M	thioredoxin reductase
AFK25_12980	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
AFK25_12985	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
AFK25_12990	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
AFK25_12995	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
AFK25_13000	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
AFK25_13005	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
AFK25_13010	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
AFK25_13015	ENOG4108IQ6	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
AFK25_13020	ENOG4108S4C	acetyltransferase
AFK25_13025	ENOG4107XGZ	Hydrolase
AFK25_13030	ENOG4105HKU	nucleoside recognition domain-containing protein
AFK25_13035	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
AFK25_13040	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
AFK25_13045	ENOG41086DT	Membrane protein of unknown function
AFK25_13060	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AFK25_13065	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
AFK25_13080	ENOG41062GF	Polar chromosome segregation protein
AFK25_13085	ENOG4105CN1	protease
AFK25_13090	ENOG4105DR5	peptidase
AFK25_13095	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
AFK25_13100	ENOG4105CAK	Cell division ATP-binding protein ftsE
AFK25_13125	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
AFK25_13130	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
AFK25_13150	ENOG4105MQ3	flagellar protein FliS
AFK25_13155	ENOG4107RT6	flagellar hook-associated
AFK25_13165	ENOG4105I03	Flagellin
AFK25_13170	ENOG4105D2T	synthase
AFK25_13195	ENOG4107TY6	Acylneuraminate cytidylyltransferase
AFK25_13200	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
AFK25_13205	ENOG4105C5E	polysaccharide biosynthesis protein
AFK25_13220	ENOG4105I03	Flagellin
AFK25_13225	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
AFK25_13230	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
AFK25_13235	ENOG4105MKD	
AFK25_13240	ENOG4105DTJ	flagellar hook-associated protein
AFK25_13245	ENOG4105E1Q	flagellar hook-associated protein
AFK25_13295	ENOG4105WH1	Two component transcriptional regulator luxr family
AFK25_13300	ENOG4105BZU	Histidine kinase
AFK25_13305	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
AFK25_13310	ENOG4108KGH	TRANSCRIPTIONal
AFK25_13315	ENOG4105ESV	Glycosyl transferase, family 4
AFK25_13325	ENOG4105JFG	SpoIID LytB domain protein
AFK25_13330	ENOG4107GBW	cellulosome anchoring protein cohesin
AFK25_13340	ENOG4105J8Z	peptidase S8 and S53, subtilisin, kexin, sedolisin
AFK25_13345	ENOG4105CGH	5'-nucleotidase
AFK25_13500	ENOG4105K4H	Nlp p60 protein
AFK25_13510	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
AFK25_13530	ENOG41067QW	Transcriptional regulator
AFK25_13560	ENOG4105CFH	Aspartokinase
AFK25_13575	ENOG4105C8Q	Methyl-accepting chemotaxis
AFK25_13605	ENOG41060AI	SEC-C motif
AFK25_13610	ENOG4105QNR	S1 RNA binding domain protein
AFK25_13615	ENOG4105EE0	oxidoreductase
AFK25_13630	ENOG4105C0D	helicase
AFK25_13640	ENOG4105C94	Transporter
AFK25_13645	ENOG4105CMR	udp-glucose 4-epimerase
AFK25_13650	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
AFK25_13655	ENOG4105KAK	Plasmid pRiA4b ORF-3 family protein
AFK25_13660	ENOG4105C6Z	Gluconate
AFK25_13665	ENOG4105CMG	Carbohydrate kinase
AFK25_13700	ENOG4105D3Q	Sugar transferase
AFK25_13705	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
AFK25_13720	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
AFK25_13730	ENOG4105CGA	flagellar basal-body rod protein FlgG
AFK25_13740	ENOG4105DFF	Rod shape-determining protein mreb
AFK25_13745	ENOG4105MT0	Sporulation transcriptional regulator spoiiid
AFK25_13750	ENOG4105FRN	stage II sporulation protein
AFK25_13760	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
AFK25_13770	ENOG4106778	Protein of unknown function (DUF1146)
AFK25_13775	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFK25_13780	ENOG4105C8S	subunit m
AFK25_13785	ENOG4105D65	subunit l
AFK25_13790	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFK25_13800	ENOG4108M11	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFK25_13805	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
AFK25_13810	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFK25_13815	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFK25_13820	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFK25_13825	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFK25_13830	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
AFK25_13835	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
AFK25_13840	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
AFK25_13845	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
AFK25_13850	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AFK25_13855	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
AFK25_13860	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AFK25_13865	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
AFK25_13880	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
AFK25_13885	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
AFK25_13890	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
AFK25_13895	ENOG4108UIC	UPF0340 protein
AFK25_13900	ENOG4108YZG	isomerase
AFK25_13905	ENOG4105C8Q	Methyl-accepting chemotaxis
AFK25_13915	ENOG410815N	Probably functions as a manganese efflux pump (By similarity)
AFK25_13920	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AFK25_13925	ENOG4108ZXQ	stage ii sporulation protein r
AFK25_13930	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
AFK25_13935	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
AFK25_13940	ENOG4107104	thymidine kinase
AFK25_13945	ENOG41082DI	50s ribosomal protein l31
AFK25_13950	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
AFK25_13955	ENOG4105CBT	Fructose-1,6-bisphosphatase
AFK25_13960	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
AFK25_13965	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
AFK25_13975	ENOG410812K	response regulator receiver protein
AFK25_13985	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
AFK25_13995	ENOG4105D5P	Methylmalonyl-coA mutase
AFK25_14005	ENOG4105C1G	acyl-Coa dehydrogenase
AFK25_14010	ENOG4105C1G	acyl-Coa dehydrogenase
AFK25_14015	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
AFK25_14025	ENOG4105DF6	Fe-S oxidoreductase
AFK25_14035	ENOG4105C75	arginyL-tRNA synthetase
AFK25_14050	ENOG4105CYW	agmatinase
AFK25_14055	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
AFK25_14060	ENOG4105BZ4	penicillin-binding protein
AFK25_14065	ENOG4108XFG	YwhD family
AFK25_14070	ENOG4108Z4T	Peptidase M50
AFK25_14075	ENOG41069HH	4-oxalocrotonate tautomerase
AFK25_14085	ENOG4105DCI	Phosphohydrolase
AFK25_14090	ENOG4105QAT	UPF0741 protein
AFK25_14095	ENOG4108VCI	transcription factor, rsfa family
AFK25_14110	ENOG4105JGI	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity)
AFK25_14115	ENOG4108IJ2	phosphate acetyltransferase
AFK25_14120	ENOG4108UM1	dedA family
AFK25_14125	ENOG4107JTW	chlorite dismutase
AFK25_14130	ENOG4108VKI	Cell wall hydrolase
AFK25_14150	ENOG4105CG3	alpha amylase, catalytic region
AFK25_14155	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
AFK25_14165	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
AFK25_14170	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
AFK25_14175	ENOG4108JU3	Alkyl hydroperoxide reductase
AFK25_14190	ENOG4108RJ9	Glycosyl transferase, family 2
AFK25_14195	ENOG41079KZ	Major Facilitator Superfamily
AFK25_14200	ENOG4105KG3	cytidine deaminase
AFK25_14210	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
AFK25_14220	ENOG4107RHR	regulatoR
AFK25_14230	ENOG4105D7K	pfkb domain protein
AFK25_14235	ENOG4105C5Y	PTS System
AFK25_14245	ENOG4105C5Y	PTS System
AFK25_14250	ENOG4108K8K	Transcriptional regulator
AFK25_14255	ENOG4105DCF	alanine dehydrogenase
AFK25_14265	ENOG4105E5Q	amino acid AbC transporter
AFK25_14270	ENOG4106PMH	Extracellular solute-binding protein family 3
AFK25_14280	ENOG4105F1A	Pyruvate formate-lyase
AFK25_14285	ENOG4107URF	beta-phospho-glucomutase
AFK25_14290	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
AFK25_14295	ENOG4108Z66	YbaK ebsC protein
AFK25_14300	ENOG4108P49	AntiSigma factor
AFK25_14305	ENOG4105JVQ	RNA Polymerase
AFK25_14335	ENOG4108RDQ	ABC transporter
AFK25_14340	ENOG41064SH	Protein of unknown function (DUF2705)
AFK25_14345	ENOG41064J9	
AFK25_14350	ENOG4106NWU	
AFK25_14355	ENOG41060CM	Protein of unknown function (DUF2712)
AFK25_14365	ENOG4105BZU	Histidine kinase
AFK25_14375	ENOG4108RDQ	ABC transporter
AFK25_14395	ENOG4108EKI	Dehydrogenase
AFK25_14415	ENOG4105E1K	spore germination protein
AFK25_14420	ENOG4108B31	Spore germination protein
AFK25_14430	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AFK25_14435	ENOG4105F38	ABC transporter, permease
AFK25_14440	ENOG4105D38	putrescine abc transporter
AFK25_14445	ENOG4107RUE	extracellular solute-binding protein family 1
AFK25_14450	ENOG4105DUX	Transporter
AFK25_14455	ENOG4105W5Q	DNA repair protein (RadC
AFK25_14495	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
AFK25_14510	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
AFK25_14515	ENOG4105C0H	protease
AFK25_14520	ENOG4105Q2H	domain protein
AFK25_14535	ENOG4105BZU	Histidine kinase
AFK25_14540	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AFK25_14555	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
AFK25_14560	ENOG4105CDU	Replicative dna helicase
AFK25_14565	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
AFK25_14570	ENOG4105BZR	domain protein
AFK25_14575	ENOG4108XMW	Membrane
AFK25_14580	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
AFK25_14585	ENOG4108UUM	single-stranded DNA-binding protein
AFK25_14590	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
AFK25_14595	ENOG4105C3G	gtp-binding protein
AFK25_14600	ENOG4105VDK	protein, conserved in bacteria
AFK25_14605	ENOG4105D8X	mechanosensitive ion channel
AFK25_14610	ENOG4108ZDA	Sporulation protein YyaC
AFK25_14620	ENOG4105FA0	parb-like partition protein
AFK25_14625	ENOG4107QJE	Chromosome Partitioning Protein
AFK25_14630	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
AFK25_14635	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
AFK25_14640	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
AFK25_14645	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
AFK25_14650	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
AFK25_14655	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AFK25_14660	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
AFK25_14665	ENOG4105VG0	50S ribosomal protein l34