locus-tag	class	description
AFK25_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFK25_00010	COG0592	DNA-directed DNA polymerase activity
AFK25_00015	COG2501	S4 domain
AFK25_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFK25_00025	COG0187	DNA topoisomerase II activity
AFK25_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFK25_00070	COG0516	GMP reductase activity
AFK25_00070	COG0517	IMP dehydrogenase activity
AFK25_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AFK25_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AFK25_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFK25_00105	COG1428	Deoxynucleoside kinase
AFK25_00110	COG1428	Deoxynucleoside kinase
AFK25_00115	COG0590	tRNA wobble adenosine to inosine editing
AFK25_00120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AFK25_00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFK25_00130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFK25_00175	COG1982	Orn Lys Arg decarboxylase major
AFK25_00180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFK25_00185	COG0470	DNA polymerase III
AFK25_00190	COG1774	PSP1 C-terminal conserved region
AFK25_00195	COG4467	Involved in initiation control of chromosome replication
AFK25_00200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AFK25_00205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AFK25_00210	COG2002	toxin-antitoxin pair type II binding
AFK25_00220	COG0084	hydrolase, TatD family'
AFK25_00225	COG3584	3D domain protein
AFK25_00225	COG3583	domain protein
AFK25_00235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFK25_00245	COG4466	Protein conserved in bacteria
AFK25_00250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFK25_00255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFK25_00260	COG0251	oxidation-reduction process
AFK25_00265	COG2088	sporulation resulting in formation of a cellular spore
AFK25_00270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFK25_00275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFK25_00280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFK25_00285	COG0193	aminoacyl-tRNA hydrolase activity
AFK25_00295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFK25_00300	COG2002	toxin-antitoxin pair type II binding
AFK25_00305	COG2244	polysaccharide biosynthetic process
AFK25_00310	COG3956	TIGRFAM MazG family protein
AFK25_00315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AFK25_00330	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AFK25_00335	COG1098	S1 RNA binding domain
AFK25_00350	COG2208	phosphoserine phosphatase activity
AFK25_00355	COG2304	oxidoreductase activity
AFK25_00360	COG0515	serine threonine protein kinase
AFK25_00365	COG0037	tRNA processing
AFK25_00375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFK25_00380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFK25_00385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AFK25_00390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFK25_00395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFK25_00400	COG0512	Glutamine amidotransferase of anthranilate synthase
AFK25_00405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFK25_00410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFK25_00415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFK25_00420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AFK25_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFK25_00455	COG3880	PFAM UvrB UvrC protein
AFK25_00460	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AFK25_00465	COG0542	response to heat
AFK25_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFK25_00475	COG4956	integral membrane protein (PIN domain superfamily)
AFK25_00480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFK25_00485	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFK25_00490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFK25_00495	COG1045	serine acetyltransferase
AFK25_00500	COG0215	cysteine-tRNA ligase activity
AFK25_00505	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AFK25_00510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFK25_00515	COG3688	RNA-binding protein containing a PIN domain
AFK25_00525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFK25_00530	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFK25_00535	COG0250	Participates in transcription elongation, termination and antitermination
AFK25_00540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFK25_00545	COG0081	regulation of translation
AFK25_00550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFK25_00555	COG0222	ribosome binding
AFK25_00560	COG2813	Specifically methylates the guanine in position
AFK25_00565	COG0085	RNA polymerase activity
AFK25_00570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFK25_00575	COG1358	cellular component organization or biogenesis
AFK25_00580	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFK25_00585	COG0049	tRNA binding
AFK25_00590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFK25_00595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFK25_00600	COG0051	transcription antitermination factor activity, RNA binding
AFK25_00605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFK25_00610	COG0088	Forms part of the polypeptide exit tunnel
AFK25_00615	COG0089	rRNA binding
AFK25_00620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFK25_00625	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFK25_00630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFK25_00635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFK25_00640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFK25_00645	COG0255	Belongs to the universal ribosomal protein uL29 family
AFK25_00650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFK25_00655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFK25_00660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFK25_00665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFK25_00670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFK25_00675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFK25_00680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFK25_00685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFK25_00690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFK25_00695	COG1841	ribosomal large subunit assembly
AFK25_00700	COG0200	Binds to the 23S rRNA
AFK25_00705	COG0201	protein transport
AFK25_00710	COG0563	adenylate kinase activity
AFK25_00715	COG0024	Methionine aminopeptidase
AFK25_00720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFK25_00725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFK25_00730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFK25_00735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFK25_00740	COG0202	RNA polymerase activity
AFK25_00745	COG0203	ribosomal protein L17
AFK25_00750	COG1122	ATPase activity
AFK25_00755	COG1122	ATPase activity
AFK25_00760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AFK25_00765	COG0101	tRNA pseudouridine synthase activity
AFK25_00770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFK25_00775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFK25_00785	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFK25_00790	COG0489	protein tyrosine kinase activity
AFK25_00800	COG2194	sulfuric ester hydrolase activity
AFK25_00805	COG0726	polysaccharide deacetylase
AFK25_00880	COG1595	DNA-templated transcription, initiation
AFK25_00885	COG5662	AntiSigma factor
AFK25_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AFK25_00895	COG4856	YbbR-like protein
AFK25_00900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFK25_00905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFK25_00930	COG0697	spore germination
AFK25_00935	COG2207	Transcriptional regulator
AFK25_00935	COG1917	Cupin 2, conserved barrel domain protein
AFK25_00960	COG2197	response regulator
AFK25_00975	COG0789	Transcriptional regulator
AFK25_00990	COG1966	Carbon starvation protein
AFK25_01005	COG1960	acyl-CoA dehydrogenase activity
AFK25_01010	COG0318	PFAM AMP-dependent synthetase and ligase
AFK25_01015	COG0439	Biotin carboxylase
AFK25_01020	COG0511	ligase activity, forming carbon-carbon bonds
AFK25_01025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFK25_01030	COG1024	Enoyl-CoA hydratase
AFK25_01035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFK25_01040	COG0726	polysaccharide deacetylase
AFK25_01050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFK25_01070	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFK25_01075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AFK25_01080	COG0513	Belongs to the DEAD box helicase family
AFK25_01085	COG0736	holo-[acyl-carrier-protein] synthase activity
AFK25_01090	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AFK25_01095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFK25_01100	COG0864	Transcriptional regulator
AFK25_01105	COG2337	Toxic component of a toxin-antitoxin (TA) module
AFK25_01110	COG2183	response to ionizing radiation
AFK25_01115	COG3091	SprT-like family
AFK25_01155	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFK25_01200	COG0802	atpase or kinase
AFK25_01205	COG1214	PFAM Peptidase M22, glycoprotease
AFK25_01210	COG0456	acetyltransferase
AFK25_01215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFK25_01220	COG0488	(ABC) transporter
AFK25_01225	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AFK25_01235	COG1266	CAAX protease self-immunity
AFK25_01240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFK25_01245	COG0459	protein refolding
AFK25_01255	COG0519	Catalyzes the synthesis of GMP from XMP
AFK25_01255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFK25_01260	COG2252	PERMEase
AFK25_01285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFK25_01290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AFK25_01295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFK25_01300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFK25_01305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFK25_01310	COG0047	phosphoribosylformylglycinamidine synthase activity
AFK25_01315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFK25_01320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AFK25_01325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFK25_01330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AFK25_01335	COG0138	bifunctional purine biosynthesis protein purh
AFK25_01340	COG0151	Belongs to the GarS family
AFK25_01350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AFK25_01355	COG1470	cell adhesion involved in biofilm formation
AFK25_01360	COG4496	protein, YerC YecD
AFK25_01365	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AFK25_01375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFK25_01380	COG4851	CamS sex pheromone cAM373 precursor
AFK25_01385	COG1012	belongs to the aldehyde dehydrogenase family
AFK25_01395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AFK25_01400	COG1115	amino acid carrier protein
AFK25_01405	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFK25_01410	COG0154	amidase activity
AFK25_01415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFK25_01430	COG1012	belongs to the aldehyde dehydrogenase family
AFK25_01435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFK25_01450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AFK25_01455	COG3437	response regulator, receiver
AFK25_01465	COG1842	Phage shock protein A
AFK25_01475	COG5002	protein histidine kinase activity
AFK25_01480	COG0745	RESPONSE REGULATOR receiver
AFK25_01500	COG1597	lipid kinase activity
AFK25_01510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFK25_01560	COG0577	efflux transmembrane transporter activity
AFK25_01560	COG1136	(ABC) transporter
AFK25_01575	COG1136	(ABC) transporter
AFK25_01575	COG0577	efflux transmembrane transporter activity
AFK25_01585	COG5002	protein histidine kinase activity
AFK25_01590	COG2211	Major facilitator Superfamily
AFK25_01610	COG2226	methyltransferase
AFK25_01630	COG5002	protein histidine kinase activity
AFK25_01635	COG1595	DNA-templated transcription, initiation
AFK25_01650	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AFK25_01655	COG0840	transmembrane signaling receptor activity
AFK25_01665	COG3300	MHYT domain
AFK25_01665	COG5001	Diguanylate cyclase
AFK25_01670	COG0791	NLP P60 protein
AFK25_01670	COG1388	LysM domain
AFK25_01675	COG0861	Integral membrane protein TerC family
AFK25_01680	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFK25_01685	COG0010	Belongs to the arginase family
AFK25_01705	COG1254	Belongs to the acylphosphatase family
AFK25_01715	COG1648	precorrin-2 dehydrogenase activity
AFK25_01730	COG0529	Catalyzes the synthesis of activated sulfate
AFK25_01735	COG2046	Belongs to the sulfate adenylyltransferase family
AFK25_01740	COG0306	phosphate transporter
AFK25_01745	COG0175	sulfate reduction
AFK25_01755	COG4840	Belongs to the UPF0435 family
AFK25_01760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFK25_01770	COG1295	ribonuclease BN
AFK25_01780	COG0477	Major facilitator Superfamily
AFK25_01785	COG0387	Pfam Sodium calcium exchanger
AFK25_01795	COG0535	radical SAM domain protein
AFK25_01815	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AFK25_01835	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFK25_01855	COG0840	transmembrane signaling receptor activity
AFK25_01870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFK25_01875	COG1090	epimerase
AFK25_01880	COG2137	regulation of response to DNA damage stimulus
AFK25_01890	COG1620	l-lactate permease
AFK25_01905	COG1988	membrane-bound metal-dependent
AFK25_01925	COG3557	Belongs to the UPF0374 family
AFK25_01930	COG0444	Belongs to the ABC transporter superfamily
AFK25_01935	COG4608	Belongs to the ABC transporter superfamily
AFK25_01940	COG0747	negative chemotaxis
AFK25_01955	COG4129	membrane
AFK25_01960	COG0069	glutamate synthase activity
AFK25_01960	COG0067	glutamate synthase
AFK25_01960	COG0070	glutamate synthase
AFK25_01965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFK25_01970	COG4555	ABC transporter
AFK25_01990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFK25_01995	COG0735	belongs to the Fur family
AFK25_02195	COG3382	B3 4 domain protein
AFK25_02200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFK25_02210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFK25_02215	COG2766	serine protein kinase
AFK25_02220	COG2718	Belongs to the UPF0229 family
AFK25_02255	COG1396	sequence-specific DNA binding
AFK25_02260	COG1396	sequence-specific DNA binding
AFK25_02350	COG0582	viral genome integration into host DNA
AFK25_02390	COG0740	serine-type endopeptidase activity
AFK25_02510	COG4824	toxin secretion phage lysis holin
AFK25_02515	COG5632	N-Acetylmuramoyl-L-alanine amidase
AFK25_02550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFK25_02555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFK25_02555	COG0425	Belongs to the sulfur carrier protein TusA family
AFK25_02560	COG2210	Belongs to the sulfur carrier protein TusA family
AFK25_02565	COG0425	Belongs to the sulfur carrier protein TusA family
AFK25_02570	COG0730	response to heat
AFK25_02580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFK25_02580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFK25_02585	COG2738	Putative neutral zinc metallopeptidase
AFK25_02590	COG1253	flavin adenine dinucleotide binding
AFK25_02595	COG0564	pseudouridine synthase activity
AFK25_02605	COG3118	belongs to the thioredoxin family
AFK25_02610	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AFK25_02615	COG0517	IMP dehydrogenase activity
AFK25_02620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFK25_02635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFK25_02640	COG0330	HflC and HflK could
AFK25_02645	COG0330	HflC and HflK could
AFK25_02650	COG2719	SpoVR family
AFK25_02655	COG1846	Transcriptional regulator
AFK25_02660	COG0477	Major facilitator Superfamily
AFK25_02665	COG0366	Alpha amylase catalytic
AFK25_02680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AFK25_02685	COG4721	ABC-type cobalt transport system, permease component
AFK25_02690	COG1122	ATPase activity
AFK25_02695	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AFK25_02700	COG0352	thiamine-phosphate diphosphorylase activity
AFK25_02705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFK25_02715	COG2022	thiamine diphosphate biosynthetic process
AFK25_02720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFK25_02725	COG0351	phosphomethylpyrimidine kinase
AFK25_02730	COG1253	flavin adenine dinucleotide binding
AFK25_02735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFK25_02740	COG0765	amino acid transport
AFK25_02745	COG1126	abc transporter atp-binding protein
AFK25_02760	COG3842	ATPase activity
AFK25_02765	COG2508	Transcriptional regulator
AFK25_02775	COG4399	Belongs to the UPF0754 family
AFK25_02780	COG3679	Belongs to the UPF0342 family
AFK25_02785	COG0561	phosphatase activity
AFK25_02790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFK25_02805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AFK25_02820	COG1846	Transcriptional regulator
AFK25_02840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFK25_02845	COG0537	adenosine 5'-monophosphoramidase activity
AFK25_02850	COG1131	(ABC) transporter
AFK25_02855	COG4473	ABC transporter
AFK25_02860	COG1473	amidohydrolase
AFK25_02865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFK25_02870	COG2329	Antibiotic biosynthesis monooxygenase
AFK25_02875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFK25_02890	COG1309	transcriptional regulator
AFK25_02895	COG1511	domain protein
AFK25_02900	COG1609	Transcriptional regulator
AFK25_02905	COG1653	transport
AFK25_02925	COG1234	tRNA 3'-trailer cleavage
AFK25_02940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFK25_02965	COG0318	PFAM AMP-dependent synthetase and ligase
AFK25_02975	COG4120	Belongs to the binding-protein-dependent transport system permease family
AFK25_02980	COG1116	anion transmembrane transporter activity
AFK25_02980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFK25_03000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AFK25_03005	COG1999	signal sequence binding
AFK25_03010	COG0501	Belongs to the peptidase M48B family
AFK25_03015	COG2224	Isocitrate lyase
AFK25_03020	COG4903	ComK protein
AFK25_03025	COG0398	Pfam SNARE associated Golgi protein
AFK25_03030	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AFK25_03035	COG1074	ATP-dependent DNA helicase activity
AFK25_03040	COG0420	3'-5' exonuclease activity
AFK25_03045	COG0419	ATPase involved in DNA repair
AFK25_03050	COG1403	HNH endonuclease
AFK25_03090	COG0318	PFAM AMP-dependent synthetase and ligase
AFK25_03095	COG2311	Membrane
AFK25_03105	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFK25_03110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFK25_03120	COG5001	Diguanylate cyclase
AFK25_03120	COG3300	MHYT domain
AFK25_03130	COG0367	asparagine synthase
AFK25_03145	COG1562	ergosterol biosynthetic process
AFK25_03160	COG0463	Glycosyl transferase, family 2
AFK25_03170	COG0534	Mate efflux family protein
AFK25_03185	COG2182	Extracellular solute-binding protein
AFK25_03190	COG1175	transmembrane transport
AFK25_03195	COG3833	ABC-type maltose transport systems, permease component
AFK25_03200	COG0366	Alpha amylase catalytic
AFK25_03200	COG1874	Beta-galactosidase
AFK25_03220	COG0310	cobalt ion transport
AFK25_03225	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
AFK25_03235	COG1122	ATPase activity
AFK25_03260	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AFK25_03290	COG1492	cobalamin metabolic process
AFK25_03295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AFK25_03305	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AFK25_03310	COG1410	methionine synthase
AFK25_03310	COG0646	methionine synthase
AFK25_03315	COG0646	methionine synthase
AFK25_03315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AFK25_03320	COG1666	GTP binding
AFK25_03330	COG0840	transmembrane signaling receptor activity
AFK25_03335	COG1307	EDD domain protein, DegV family
AFK25_03340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AFK25_03345	COG0561	phosphatase activity
AFK25_03350	COG1073	alpha beta
AFK25_03360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFK25_03365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFK25_03370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFK25_03375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFK25_03395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFK25_03415	COG2267	carboxylic ester hydrolase activity
AFK25_03425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFK25_03430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFK25_03435	COG5504	Zn-dependent protease
AFK25_03450	COG0180	Tryptophanyl-tRNA synthetase
AFK25_03460	COG4166	transmembrane transport
AFK25_03465	COG0601	transmembrane transport
AFK25_03470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFK25_03475	COG0444	Belongs to the ABC transporter superfamily
AFK25_03480	COG4608	Belongs to the ABC transporter superfamily
AFK25_03490	COG1393	Belongs to the ArsC family
AFK25_03495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFK25_03500	COG4862	establishment of competence for transformation
AFK25_03510	COG1164	Oligoendopeptidase f
AFK25_03525	COG2346	COG2346, Truncated hemoglobins
AFK25_03530	COG0741	lytic transglycosylase activity
AFK25_03535	COG4116	CYTH
AFK25_03545	COG2357	RelA SpoT domain protein
AFK25_03550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFK25_03555	COG0564	pseudouridine synthase activity
AFK25_03560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFK25_03575	COG0772	Belongs to the SEDS family
AFK25_03580	COG2239	Acts as a magnesium transporter
AFK25_03595	COG0438	transferase activity, transferring glycosyl groups
AFK25_03600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFK25_03605	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFK25_03660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFK25_03675	COG2323	membrane
AFK25_03685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK25_03700	COG0210	DNA helicase
AFK25_03720	COG2323	membrane
AFK25_03725	COG2153	protein acetylation
AFK25_03730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AFK25_03735	COG2382	esterase
AFK25_03740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFK25_03745	COG1970	mechanosensitive ion channel activity
AFK25_03750	COG3384	dioxygenase
AFK25_03755	COG0662	Cupin 2, conserved barrel domain protein
AFK25_03760	COG0626	cystathionine gamma-synthase activity
AFK25_03765	COG0626	cystathionine gamma-synthase activity
AFK25_03770	COG1418	mRNA catabolic process
AFK25_03785	COG4974	Belongs to the 'phage' integrase family
AFK25_03880	COG0582	viral genome integration into host DNA
AFK25_03920	COG3328	transposase activity
AFK25_03945	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFK25_04000	COG3335	DDE superfamily endonuclease
AFK25_04020	COG3335	DDE superfamily endonuclease
AFK25_04030	COG1132	(ABC) transporter
AFK25_04035	COG1132	(ABC) transporter
AFK25_04050	COG1418	mRNA catabolic process
AFK25_04055	COG0488	(ABC) transporter
AFK25_04060	COG1413	lyase activity
AFK25_04080	COG0371	Dehydrogenase
AFK25_04085	COG1464	Belongs to the NlpA lipoprotein family
AFK25_04090	COG2011	ABC-type metal ion transport system permease component
AFK25_04095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFK25_04105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFK25_04105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFK25_04125	COG1028	Short-chain dehydrogenase reductase Sdr
AFK25_04130	COG2610	gluconate transmembrane transporter activity
AFK25_04135	COG3290	protein histidine kinase activity
AFK25_04135	COG3829	transcription factor binding
AFK25_04145	COG2336	PFAM SpoVT AbrB
AFK25_04150	COG2337	Toxic component of a toxin-antitoxin (TA) module
AFK25_04155	COG0697	spore germination
AFK25_04170	COG0515	serine threonine protein kinase
AFK25_04175	COG1396	sequence-specific DNA binding
AFK25_04180	COG0252	asparaginase activity
AFK25_04185	COG1027	Aspartate ammonia-lyase
AFK25_04195	COG3852	Histidine kinase
AFK25_04205	COG3457	Alanine racemase
AFK25_04210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFK25_04215	COG2226	methyltransferase
AFK25_04225	COG0463	Glycosyl transferase, family 2
AFK25_04240	COG0531	amino acid
AFK25_04245	COG0861	Integral membrane protein TerC family
AFK25_04250	COG1528	Iron-storage protein
AFK25_04260	COG0247	lactate metabolic process
AFK25_04265	COG0277	FAD linked oxidase domain protein
AFK25_04270	COG3835	regulator
AFK25_04275	COG0840	transmembrane signaling receptor activity
AFK25_04280	COG1609	Transcriptional regulator
AFK25_04285	COG1554	hydrolase, family 65, central catalytic
AFK25_04290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFK25_04305	COG0395	ABC-type sugar transport system, permease component
AFK25_04330	COG1620	l-lactate permease
AFK25_04335	COG2186	Transcriptional regulator
AFK25_04340	COG0247	lactate metabolic process
AFK25_04345	COG1139	Iron-sulfur cluster binding protein
AFK25_04350	COG1556	Lactate utilization protein
AFK25_04355	COG5002	protein histidine kinase activity
AFK25_04360	COG0840	transmembrane signaling receptor activity
AFK25_04365	COG4214	carbohydrate transport
AFK25_04370	COG1129	ABC transporter
AFK25_04375	COG1879	ABC-type sugar transport system periplasmic component
AFK25_04380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFK25_04385	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AFK25_04390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFK25_04395	COG0436	Aminotransferase
AFK25_04400	COG1850	ribulose-bisphosphate carboxylase activity
AFK25_04405	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AFK25_04410	COG0235	Class ii aldolase
AFK25_04415	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AFK25_04430	COG3852	Histidine kinase
AFK25_04440	COG0531	amino acid
AFK25_04445	COG1131	(ABC) transporter
AFK25_04460	COG0542	response to heat
AFK25_04470	COG5002	protein histidine kinase activity
AFK25_04475	COG0745	RESPONSE REGULATOR receiver
AFK25_04490	COG3949	Membrane
AFK25_04500	COG5278	phosphoserine phosphatase activity
AFK25_04500	COG0840	transmembrane signaling receptor activity
AFK25_04510	COG0704	Plays a role in the regulation of phosphate uptake
AFK25_04515	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFK25_04520	COG0720	synthase
AFK25_04535	COG0702	epimerase
AFK25_04560	COG4191	Histidine kinase
AFK25_04565	COG0778	Nitroreductase
AFK25_04570	COG1733	regulation of RNA biosynthetic process
AFK25_04585	COG0840	transmembrane signaling receptor activity
AFK25_04590	COG2111	Na H antiporter
AFK25_04590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFK25_04595	COG2111	Na H antiporter
AFK25_04600	COG1006	Multisubunit Na H antiporter MnhC subunit
AFK25_04605	COG0651	ATP synthesis coupled electron transport
AFK25_04610	COG1863	multisubunit Na H antiporter MnhE subunit
AFK25_04615	COG2212	antiporter activity
AFK25_04620	COG1320	monovalent cation:proton antiporter activity
AFK25_04625	COG2267	carboxylic ester hydrolase activity
AFK25_04630	COG3942	CHAP domain
AFK25_04630	COG1388	LysM domain
AFK25_04640	COG3711	transcriptional antiterminator
AFK25_04650	COG1263	PTS System
AFK25_04650	COG2190	(PTS) system
AFK25_04650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK25_04665	COG0840	transmembrane signaling receptor activity
AFK25_04675	COG2084	Dehydrogenase
AFK25_04680	COG0436	Aminotransferase
AFK25_04695	COG2205	protein histidine kinase activity
AFK25_04710	COG0835	chemotaxis
AFK25_04710	COG0784	Response regulator, receiver
AFK25_04715	COG0745	RESPONSE REGULATOR receiver
AFK25_04715	COG3706	GGDEF domain
AFK25_04735	COG0745	RESPONSE REGULATOR receiver
AFK25_04740	COG5002	protein histidine kinase activity
AFK25_04770	COG0248	Ppx GppA phosphatase
AFK25_04780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFK25_04785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFK25_04790	COG1408	metallophosphoesterase
AFK25_04795	COG1028	Short-chain dehydrogenase reductase Sdr
AFK25_04800	COG2200	EAL domain
AFK25_04810	COG4703	Protein of unknown function (DUF1797)
AFK25_04815	COG0517	IMP dehydrogenase activity
AFK25_04820	COG2171	N-acyltransferase activity
AFK25_04825	COG1473	amidohydrolase
AFK25_04830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK25_04835	COG0569	domain protein
AFK25_04840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFK25_04850	COG0561	phosphatase activity
AFK25_04900	COG1982	Orn Lys Arg decarboxylase major
AFK25_04920	COG1131	(ABC) transporter
AFK25_04930	COG4476	Belongs to the UPF0223 family
AFK25_04940	COG0483	inositol monophosphate 1-phosphatase activity
AFK25_04965	COG4896	Protein conserved in bacteria
AFK25_04980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFK25_04985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AFK25_04990	COG4838	Belongs to the UPF0358 family
AFK25_04995	COG0772	Belongs to the SEDS family
AFK25_05000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AFK25_05005	COG2801	Transposase and inactivated derivatives
AFK25_05010	COG1612	heme a metabolic process
AFK25_05015	COG0109	protoheme IX farnesyltransferase activity
AFK25_05040	COG3336	cytochrome c oxidase
AFK25_05055	COG2801	Transposase and inactivated derivatives
AFK25_05075	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AFK25_05080	COG2340	Cysteine-rich secretory protein family
AFK25_05100	COG3679	Belongs to the UPF0342 family
AFK25_05105	COG4471	UPF0298 protein
AFK25_05120	COG0742	ribosomal rna small subunit methyltransferase
AFK25_05125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFK25_05130	COG3314	Sporulation integral membrane protein YlbJ
AFK25_05135	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFK25_05140	COG3480	Lon protease (S16) C-terminal proteolytic domain
AFK25_05145	COG1323	Belongs to the UPF0348 family
AFK25_05150	COG1399	metal-binding, possibly nucleic acid-binding protein
AFK25_05155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFK25_05160	COG1024	Enoyl-CoA hydratase
AFK25_05170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AFK25_05180	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AFK25_05185	COG0275	rRNA processing
AFK25_05190	COG4839	cell division protein FtsL
AFK25_05200	COG0768	penicillin binding
AFK25_05205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFK25_05210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFK25_05215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFK25_05220	COG0772	Belongs to the SEDS family
AFK25_05225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFK25_05230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFK25_05235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFK25_05240	COG3879	Bacterial protein of unknown function (DUF881)
AFK25_05245	COG3879	Bacterial protein of unknown function (DUF881)
AFK25_05250	COG3856	small basic protein
AFK25_05255	COG0849	cell division
AFK25_05260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFK25_05270	COG1191	sigma factor activity
AFK25_05275	COG1191	sigma factor activity
AFK25_05280	COG1873	PFAM PRC-barrel domain
AFK25_05290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFK25_05295	COG1799	cell septum assembly
AFK25_05300	COG0762	integral membrane protein
AFK25_05305	COG2302	S4 RNA-binding domain
AFK25_05310	COG3599	regulation of cell shape
AFK25_05315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFK25_05320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFK25_05325	COG0564	pseudouridine synthase activity
AFK25_05330	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFK25_05340	COG0540	Belongs to the ATCase OTCase family
AFK25_05345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFK25_05360	COG0543	2 iron, 2 sulfur cluster binding
AFK25_05365	COG0167	dihydroorotate dehydrogenase activity
AFK25_05370	COG0284	orotidine-5'-phosphate decarboxylase activity
AFK25_05390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFK25_05395	COG1561	YicC-like family, N-terminal region
AFK25_05400	COG0194	GDP metabolic process
AFK25_05405	COG1758	RNA polymerase activity
AFK25_05410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFK25_05415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFK25_05420	COG0242	peptide deformylase activity
AFK25_05425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFK25_05430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFK25_05430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFK25_05435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFK25_05440	COG0631	protein serine/threonine phosphatase activity
AFK25_05445	COG2815	serine threonine protein kinase
AFK25_05445	COG0515	serine threonine protein kinase
AFK25_05450	COG1162	GTPase activity
AFK25_05455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFK25_05460	COG1564	THIamine pyrophosphokinase
AFK25_05470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFK25_05475	COG1302	Protein conserved in bacteria
AFK25_05480	COG1461	Dihydroxyacetone kinase
AFK25_05485	COG1760	l-serine dehydratase
AFK25_05490	COG1760	l-serine dehydratase
AFK25_05495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AFK25_05500	COG1349	DNA-binding transcription factor activity
AFK25_05505	COG0416	fatty acid biosynthetic process
AFK25_05510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFK25_05515	COG1028	Short-chain dehydrogenase reductase Sdr
AFK25_05520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFK25_05525	COG0571	ribonuclease III activity
AFK25_05530	COG1196	nuclear chromosome segregation
AFK25_05535	COG0552	protein localization to endoplasmic reticulum
AFK25_05540	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AFK25_05545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFK25_05550	COG0228	four-way junction DNA binding
AFK25_05555	COG1837	Belongs to the UPF0109 family
AFK25_05565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFK25_05570	COG0336	Belongs to the RNA methyltransferase TrmD family
AFK25_05575	COG0335	large ribosomal subunit rRNA binding
AFK25_05585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AFK25_05590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFK25_05600	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFK25_05605	COG0045	succinate-CoA ligase (ADP-forming) activity
AFK25_05610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFK25_05615	COG0758	DNA mediated transformation
AFK25_05620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFK25_05625	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AFK25_05630	COG4974	Belongs to the 'phage' integrase family
AFK25_05635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AFK25_05640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AFK25_05645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AFK25_05650	COG1815	bacterial-type flagellum-dependent cell motility
AFK25_05655	COG1558	bacterial-type flagellum-dependent cell motility
AFK25_05660	COG1677	Flagellar hook-basal body complex protein FliE
AFK25_05665	COG1766	The M ring may be actively involved in energy transduction
AFK25_05670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFK25_05675	COG1317	bacterial-type flagellum organization
AFK25_05680	COG1157	protein secretion by the type III secretion system
AFK25_05685	COG2882	bacterial-type flagellum organization
AFK25_05695	COG3144	bacterial-type flagellum assembly
AFK25_05700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AFK25_05705	COG4786	Flagellar basal body rod
AFK25_05710	COG1582	Flagellar protein (FlbD)
AFK25_05715	COG1580	Controls the rotational direction of flagella during chemotaxis
AFK25_05720	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFK25_05725	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFK25_05725	COG1776	CheC inhibitor of MCP methylation
AFK25_05730	COG2201	protein-glutamate methylesterase activity
AFK25_05735	COG3190	flagellar
AFK25_05740	COG1338	Plays a role in the flagellum-specific transport system
AFK25_05745	COG1987	bacterial-type flagellum assembly
AFK25_05750	COG1684	flagellar biosynthetic protein fliR
AFK25_05755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFK25_05760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFK25_05765	COG1419	protein localization to endoplasmic reticulum
AFK25_05770	COG0455	bacterial-type flagellum organization
AFK25_05775	COG2201	protein-glutamate methylesterase activity
AFK25_05780	COG0643	Histidine kinase
AFK25_05780	COG2198	Histidine kinase
AFK25_05785	COG0835	chemotaxis
AFK25_05790	COG1776	CheC inhibitor of MCP methylation
AFK25_05795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AFK25_05805	COG1191	sigma factor activity
AFK25_05820	COG0052	Belongs to the universal ribosomal protein uS2 family
AFK25_05825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFK25_05830	COG0528	UMP kinase activity
AFK25_05835	COG0233	cytoplasmic translational termination
AFK25_05840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFK25_05845	COG4589	Belongs to the CDS family
AFK25_05850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFK25_05855	COG0750	zinc metalloprotease
AFK25_05860	COG0442	prolyl-tRNA aminoacylation
AFK25_05865	COG2176	DNA-directed DNA polymerase activity
AFK25_05870	COG0779	Required for maturation of 30S ribosomal subunits
AFK25_05875	COG0195	Participates in both transcription termination and antitermination
AFK25_05880	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AFK25_05885	COG1358	cellular component organization or biogenesis
AFK25_05890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFK25_05895	COG1550	Protein conserved in bacteria
AFK25_05900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFK25_05905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFK25_05910	COG0196	riboflavin kinase activity
AFK25_05915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFK25_05920	COG1185	polyribonucleotide nucleotidyltransferase activity
AFK25_05925	COG0726	polysaccharide deacetylase
AFK25_05930	COG0612	Peptidase, M16
AFK25_05935	COG1873	PFAM PRC-barrel domain
AFK25_05940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFK25_05945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFK25_05950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFK25_05955	COG0527	aspartate kinase activity
AFK25_05965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFK25_05970	COG0740	serine-type endopeptidase activity
AFK25_05980	COG1674	ftsk spoiiie
AFK25_05980	COG4980	gas vesicle protein
AFK25_05985	COG2188	Transcriptional regulator
AFK25_06010	COG2508	Transcriptional regulator
AFK25_06015	COG1012	belongs to the aldehyde dehydrogenase family
AFK25_06025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFK25_06030	COG2610	gluconate transmembrane transporter activity
AFK25_06040	COG0589	response to stress
AFK25_06045	COG0659	secondary active sulfate transmembrane transporter activity
AFK25_06060	COG0579	oxidoreductase
AFK25_06075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFK25_06080	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AFK25_06090	COG1715	Restriction endonuclease
AFK25_06130	COG2816	NAD+ diphosphatase activity
AFK25_06150	COG1414	Transcriptional regulator
AFK25_06155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AFK25_06160	COG1984	allophanate hydrolase subunit 2
AFK25_06165	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AFK25_06185	COG1413	lyase activity
AFK25_06195	COG0494	nUDIX hydrolase
AFK25_06200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFK25_06230	COG3011	Protein conserved in bacteria
AFK25_06235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK25_06240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFK25_06245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFK25_06250	COG2808	Putative FMN-binding domain
AFK25_06255	COG1280	lysine exporter protein (LysE YggA)
AFK25_06265	COG1192	Involved in chromosome partitioning
AFK25_06295	COG1012	belongs to the aldehyde dehydrogenase family
AFK25_06305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFK25_06310	COG3402	PFAM membrane-flanked domain
AFK25_06315	COG3428	Bacterial PH domain
AFK25_06345	COG0583	DNA-binding transcription factor activity
AFK25_06350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AFK25_06355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFK25_06360	COG0393	Putative heavy-metal-binding
AFK25_06370	COG0640	Transcriptional regulator
AFK25_06380	COG4377	Putative membrane peptidase family (DUF2324)
AFK25_06385	COG4989	oxidoreductase activity
AFK25_06400	COG0346	lactoylglutathione lyase activity
AFK25_06405	COG2223	nitrite transmembrane transporter activity
AFK25_06410	COG1609	Transcriptional regulator
AFK25_06415	COG1741	Belongs to the pirin family
AFK25_06420	COG2259	Doxx family
AFK25_06425	COG1846	Transcriptional regulator
AFK25_06435	COG3773	Cell wall hydrolase
AFK25_06440	COG1131	(ABC) transporter
AFK25_06450	COG1309	transcriptional regulator
AFK25_06455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AFK25_06460	COG1414	Transcriptional regulator
AFK25_06470	COG2340	Cysteine-rich secretory protein family
AFK25_06480	COG3711	transcriptional antiterminator
AFK25_06490	COG0246	Mannitol dehydrogenase
AFK25_06500	COG3852	Histidine kinase
AFK25_06505	COG0784	Response regulator, receiver
AFK25_06510	COG4191	Histidine kinase
AFK25_06515	COG0765	amino acid transport
AFK25_06520	COG0765	amino acid transport
AFK25_06540	COG1742	UPF0060 membrane protein
AFK25_06545	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AFK25_06550	COG0463	Glycosyl transferase, family 2
AFK25_06555	COG2246	polysaccharide biosynthetic process
AFK25_06580	COG2986	histidine ammonia-lyase
AFK25_06585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AFK25_06590	COG1228	amidohydrolase
AFK25_06595	COG0010	Belongs to the arginase family
AFK25_06600	COG2801	Transposase and inactivated derivatives
AFK25_06625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFK25_06640	COG5609	conserved protein (DUF2294)
AFK25_06645	COG1597	lipid kinase activity
AFK25_06650	COG0701	Predicted permease
AFK25_06660	COG0789	Transcriptional regulator
AFK25_06685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFK25_06690	COG0612	Peptidase, M16
AFK25_06695	COG0612	Peptidase, M16
AFK25_06700	COG0300	oxidoreductase activity
AFK25_06715	COG1426	Protein conserved in bacteria
AFK25_06720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFK25_06725	COG1546	Belongs to the CinA family
AFK25_06725	COG1058	Belongs to the CinA family
AFK25_06730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFK25_06735	COG1418	mRNA catabolic process
AFK25_06745	COG2359	stage V sporulation protein S
AFK25_06755	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFK25_06755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFK25_06760	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFK25_06765	COG2801	Transposase and inactivated derivatives
AFK25_06770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFK25_06775	COG4550	Control of competence regulator ComK, YlbF/YmcA
AFK25_06785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AFK25_06790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AFK25_06795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFK25_06800	COG1923	regulation of RNA biosynthetic process
AFK25_06805	COG0464	growth
AFK25_06820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFK25_06825	COG0318	PFAM AMP-dependent synthetase and ligase
AFK25_06830	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFK25_06835	COG0183	Belongs to the thiolase family
AFK25_06840	COG2860	membrane
AFK25_06845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFK25_06850	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AFK25_06855	COG0789	Transcriptional regulator
AFK25_06860	COG0174	glutamine synthetase
AFK25_06865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFK25_06875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFK25_06880	COG4224	UPF0291 protein
AFK25_06890	COG3763	UPF0154 protein
AFK25_06895	COG0785	Cytochrome C biogenesis protein
AFK25_06900	COG2201	protein-glutamate methylesterase activity
AFK25_06905	COG4846	Membrane protein involved in cytochrome C biogenesis
AFK25_06930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFK25_06950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AFK25_06980	COG0432	Pfam Uncharacterised protein family UPF0047
AFK25_06985	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AFK25_06990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFK25_07000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AFK25_07000	COG2199	diguanylate cyclase activity
AFK25_07005	COG1349	DNA-binding transcription factor activity
AFK25_07010	COG1105	Belongs to the carbohydrate kinase PfkB family
AFK25_07015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK25_07015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFK25_07015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFK25_07020	COG0716	FMN binding
AFK25_07025	COG5002	protein histidine kinase activity
AFK25_07030	COG1587	Uroporphyrinogen-III synthase
AFK25_07035	COG0840	transmembrane signaling receptor activity
AFK25_07045	COG1988	membrane-bound metal-dependent
AFK25_07050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AFK25_07065	COG2814	Major facilitator Superfamily
AFK25_07070	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AFK25_07080	COG2521	methyltransferase
AFK25_07080	COG2136	Putative SAM-dependent methyltransferase
AFK25_07085	COG1301	dicarboxylic acid transport
AFK25_07095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFK25_07100	COG0805	protein transport
AFK25_07110	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AFK25_07115	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AFK25_07130	COG0375	protein maturation
AFK25_07135	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AFK25_07140	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AFK25_07145	COG0298	carbon dioxide binding
AFK25_07150	COG0409	Hydrogenase expression formation protein
AFK25_07160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AFK25_07165	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFK25_07170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFK25_07185	COG1999	signal sequence binding
AFK25_07190	COG2755	lipolytic protein G-D-S-L family
AFK25_07200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFK25_07200	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AFK25_07205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AFK25_07210	COG1832	CoA-binding protein
AFK25_07215	COG0187	DNA topoisomerase II activity
AFK25_07220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFK25_07230	COG1263	PTS System
AFK25_07230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK25_07235	COG0366	Alpha amylase catalytic
AFK25_07240	COG2188	Transcriptional regulator
AFK25_07245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFK25_07250	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFK25_07255	COG2116	formate transmembrane transporter activity
AFK25_07260	COG0788	formyltetrahydrofolate deformylase activity
AFK25_07270	COG1937	Protein conserved in bacteria
AFK25_07275	COG0714	Associated with various cellular activities
AFK25_07280	COG4548	von Willebrand factor, type A
AFK25_07285	COG1115	amino acid carrier protein
AFK25_07305	COG0551	DNA topoisomerase type I activity
AFK25_07305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFK25_07335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFK25_07350	COG0398	Pfam SNARE associated Golgi protein
AFK25_07370	COG4134	Bacterial extracellular solute-binding protein
AFK25_07415	COG1119	ATPase activity
AFK25_07425	COG1028	Short-chain dehydrogenase reductase Sdr
AFK25_07435	COG0697	spore germination
AFK25_07440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFK25_07445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFK25_07450	COG0640	Transcriptional regulator
AFK25_07460	COG3341	Caulimovirus viroplasmin
AFK25_07460	COG0328	RNA-DNA hybrid ribonuclease activity
AFK25_07480	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AFK25_07485	COG1131	(ABC) transporter
AFK25_07490	COG2755	lipolytic protein G-D-S-L family
AFK25_07500	COG1278	Cold shock
AFK25_07510	COG0826	peptidase U32
AFK25_07520	COG1131	(ABC) transporter
AFK25_07525	COG1725	Transcriptional regulator
AFK25_07545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFK25_07550	COG3546	catalase activity
AFK25_07560	COG3852	Histidine kinase
AFK25_07565	COG1115	amino acid carrier protein
AFK25_07570	COG0534	Mate efflux family protein
AFK25_07575	COG2962	Rard protein
AFK25_07580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFK25_07585	COG2056	Na+-H+ antiporter family
AFK25_07595	COG1876	peptidase activity
AFK25_07615	COG4326	sporulation control protein
AFK25_07625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFK25_07645	COG4841	protein insertion into membrane
AFK25_07650	COG0824	Thioesterase
AFK25_07670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK25_07680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFK25_07685	COG1755	Isoprenylcysteine carboxyl methyltransferase
AFK25_07690	COG3424	synthase
AFK25_07705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFK25_07710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFK25_07715	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AFK25_07720	COG1199	ATP-dependent helicase activity
AFK25_07725	COG0116	Belongs to the methyltransferase superfamily
AFK25_07745	COG0840	transmembrane signaling receptor activity
AFK25_07765	COG2208	phosphoserine phosphatase activity
AFK25_07770	COG1024	Enoyl-CoA hydratase
AFK25_07775	COG0352	thiamine-phosphate diphosphorylase activity
AFK25_07780	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AFK25_07785	COG1151	hydroxylamine reductase activity
AFK25_07805	COG1525	nuclease
AFK25_07815	COG1131	(ABC) transporter
AFK25_07835	COG5001	Diguanylate cyclase
AFK25_07835	COG3300	MHYT domain
AFK25_07845	COG0640	Transcriptional regulator
AFK25_07850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFK25_07850	COG1199	ATP-dependent helicase activity
AFK25_07860	COG0004	ammonium transporteR
AFK25_07865	COG3069	C4-dicarboxylate transmembrane transporter activity
AFK25_07875	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFK25_07880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFK25_07890	COG1132	(ABC) transporter
AFK25_07895	COG1132	(ABC) transporter
AFK25_07905	COG0438	transferase activity, transferring glycosyl groups
AFK25_07910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFK25_07915	COG0386	Belongs to the glutathione peroxidase family
AFK25_07920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFK25_07920	COG3153	acetyltransferase
AFK25_07925	COG0456	acetyltransferase
AFK25_07945	COG4948	Mandelate Racemase Muconate Lactonizing
AFK25_07950	COG4214	carbohydrate transport
AFK25_07955	COG1129	ABC transporter
AFK25_07960	COG4213	ABC transporter substrate-binding protein
AFK25_07965	COG3279	Response regulator of the LytR AlgR family
AFK25_07970	COG2972	Histidine kinase
AFK25_07980	COG3290	protein histidine kinase activity
AFK25_07980	COG0840	transmembrane signaling receptor activity
AFK25_07985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFK25_07990	COG2814	Major facilitator Superfamily
AFK25_08010	COG3853	Toxic anion resistance protein (TelA)
AFK25_08035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFK25_08040	COG1321	iron dependent repressor
AFK25_08040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFK25_08045	COG1121	(ABC) transporter
AFK25_08050	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFK25_08055	COG0531	amino acid
AFK25_08090	COG1272	protein, Hemolysin III
AFK25_08095	COG1960	acyl-CoA dehydrogenase activity
AFK25_08100	COG0318	PFAM AMP-dependent synthetase and ligase
AFK25_08110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFK25_08125	COG1668	transmembrane transport
AFK25_08130	COG4152	abc transporter atp-binding protein
AFK25_08140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFK25_08145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFK25_08155	COG1120	ATPase activity
AFK25_08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK25_08165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK25_08170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFK25_08180	COG1028	Short-chain dehydrogenase reductase Sdr
AFK25_08185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFK25_08195	COG2211	Major facilitator Superfamily
AFK25_08260	COG0644	oxidoreductase
AFK25_08265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFK25_08280	COG1012	belongs to the aldehyde dehydrogenase family
AFK25_08285	COG0028	Belongs to the TPP enzyme family
AFK25_08290	COG0531	amino acid
AFK25_08300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AFK25_08310	COG1960	acyl-CoA dehydrogenase activity
AFK25_08320	COG0129	dihydroxy-acid dehydratase activity
AFK25_08325	COG0493	'glutamate synthase
AFK25_08330	COG0069	glutamate synthase activity
AFK25_08330	COG0070	glutamate synthase
AFK25_08330	COG0067	glutamate synthase
AFK25_08335	COG0583	DNA-binding transcription factor activity
AFK25_08360	COG1012	belongs to the aldehyde dehydrogenase family
AFK25_08380	COG0367	asparagine synthase
AFK25_08385	COG2132	Multicopper oxidase
AFK25_08395	COG2217	Heavy metal translocating P-type atpase
AFK25_08400	COG1937	Protein conserved in bacteria
AFK25_08425	COG0745	RESPONSE REGULATOR receiver
AFK25_08430	COG5002	protein histidine kinase activity
AFK25_08430	COG3850	Histidine kinase
AFK25_08470	COG0656	L-ascorbic acid biosynthetic process
AFK25_08475	COG0535	radical SAM domain protein
AFK25_08480	COG0110	maltose O-acetyltransferase activity
AFK25_08485	COG1968	undecaprenyl-diphosphatase activity
AFK25_08500	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFK25_08540	COG0210	DNA helicase
AFK25_08555	COG1061	Type III restriction enzyme res subunit
AFK25_08580	COG0475	glutathione-regulated potassium exporter activity
AFK25_08580	COG0569	domain protein
AFK25_08585	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AFK25_08590	COG4106	trans-aconitate 2-methyltransferase activity
AFK25_08595	COG0596	Alpha beta hydrolase
AFK25_08600	COG0156	8-amino-7-oxononanoate synthase activity
AFK25_08605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK25_08610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK25_08615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFK25_08620	COG1120	ATPase activity
AFK25_08630	COG0840	transmembrane signaling receptor activity
AFK25_08635	COG1929	Belongs to the glycerate kinase type-1 family
AFK25_08670	COG2217	Heavy metal translocating P-type atpase
AFK25_08675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AFK25_08700	COG3331	DNA recombination
AFK25_08705	COG4499	WXG100 protein secretion system (Wss), protein YukC
AFK25_08705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFK25_08715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFK25_08720	COG3935	DnaD domain protein
AFK25_08725	COG0017	Asparaginyl-tRNA synthetase
AFK25_08765	COG1199	ATP-dependent helicase activity
AFK25_08765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFK25_08770	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFK25_08775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFK25_08780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFK25_08790	COG0617	tRNA 3'-terminal CCA addition
AFK25_08795	COG0438	transferase activity, transferring glycosyl groups
AFK25_08800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFK25_08805	COG1803	Methylglyoxal synthase
AFK25_08810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFK25_08815	COG1694	Mazg nucleotide pyrophosphohydrolase
AFK25_08820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AFK25_08830	COG4347	Protein of unknown function (DUF1405)
AFK25_08855	COG5582	Belongs to the UPF0302 family
AFK25_08860	COG0457	Tetratricopeptide repeat
AFK25_08865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFK25_08870	COG0287	Prephenate dehydrogenase
AFK25_08875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFK25_08880	COG0159	tryptophan synthase activity
AFK25_08885	COG0133	tryptophan synthase activity
AFK25_08890	COG0135	phosphoribosylanthranilate isomerase activity
AFK25_08895	COG0134	indole-3-glycerol-phosphate synthase activity
AFK25_08900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFK25_08910	COG4401	Chorismate mutase type I
AFK25_08915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFK25_08920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFK25_08925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AFK25_08930	COG0105	UTP biosynthetic process
AFK25_08940	COG2226	methyltransferase
AFK25_08955	COG0302	gtp cyclohydrolase
AFK25_08965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFK25_08980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFK25_08985	COG1160	GTP binding
AFK25_09005	COG1304	FMN binding
AFK25_09010	COG0539	negative regulation of cytoplasmic translation
AFK25_09020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFK25_09030	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AFK25_09035	COG2339	peptidase activity
AFK25_09040	COG3773	Cell wall hydrolase
AFK25_09040	COG3409	Peptidoglycan-binding domain 1 protein
AFK25_09045	COG2959	enzyme of heme biosynthesis
AFK25_09050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFK25_09055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFK25_09060	COG0492	ferredoxin-NADP+ reductase activity
AFK25_09065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AFK25_09070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFK25_09075	COG4862	establishment of competence for transformation
AFK25_09080	COG0789	Transcriptional regulator
AFK25_09085	COG1408	metallophosphoesterase
AFK25_09105	COG3546	catalase activity
AFK25_09120	COG1266	CAAX protease self-immunity
AFK25_09125	COG0514	ATP-dependent DNA helicase (RecQ)
AFK25_09130	COG4955	Helix-turn-helix domain
AFK25_09145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFK25_09150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFK25_09165	COG2096	Adenosyltransferase
AFK25_09180	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AFK25_09195	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AFK25_09200	COG1120	ATPase activity
AFK25_09205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK25_09210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFK25_09215	COG5002	protein histidine kinase activity
AFK25_09220	COG0745	RESPONSE REGULATOR receiver
AFK25_09225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFK25_09230	COG1333	cytochrome c biogenesis protein
AFK25_09235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK25_09240	COG1187	pseudouridine synthase activity
AFK25_09245	COG0700	Nucleoside recognition
AFK25_09250	COG2715	membrane protein required for spore maturation
AFK25_09255	COG1686	Belongs to the peptidase S11 family
AFK25_09260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AFK25_09280	COG0789	Transcriptional regulator
AFK25_09285	COG0640	Transcriptional regulator
AFK25_09295	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFK25_09315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFK25_09320	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AFK25_09325	COG1547	Domain of unknown function (DUF309)
AFK25_09335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFK25_09340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFK25_09340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFK25_09345	COG0307	riboflavin synthase, alpha
AFK25_09350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFK25_09350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFK25_09355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFK25_09360	COG4086	secreted protein
AFK25_09365	COG0019	diaminopimelate decarboxylase activity
AFK25_09370	COG0697	spore germination
AFK25_09385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFK25_09410	COG2172	sigma factor antagonist activity
AFK25_09420	COG1686	Belongs to the peptidase S11 family
AFK25_09440	COG4974	Belongs to the 'phage' integrase family
AFK25_09450	COG0735	belongs to the Fur family
AFK25_09455	COG1300	Membrane
AFK25_09460	COG0494	nUDIX hydrolase
AFK25_09465	COG0667	Aldo Keto reductase
AFK25_09480	COG2181	nitrate reductase activity
AFK25_09485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AFK25_09490	COG1140	nitrate reductase beta subunit
AFK25_09495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AFK25_09505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFK25_09510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFK25_09515	COG0315	cyclic pyranopterin monophosphate synthase activity
AFK25_09525	COG0314	molybdopterin synthase activity
AFK25_09530	COG1763	Mo-molybdopterin cofactor biosynthetic process
AFK25_09535	COG0303	'Molybdopterin
AFK25_09550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFK25_09555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AFK25_09560	COG4149	molybdate abc transporter
AFK25_09570	COG2223	nitrite transmembrane transporter activity
AFK25_09575	COG2223	nitrite transmembrane transporter activity
AFK25_09580	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AFK25_09590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK25_09595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFK25_09605	COG1131	(ABC) transporter
AFK25_09635	COG0535	radical SAM domain protein
AFK25_09645	COG1379	DNA repair
AFK25_09655	COG0300	oxidoreductase activity
AFK25_09660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFK25_09665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFK25_09670	COG1902	pentaerythritol trinitrate reductase activity
AFK25_09680	COG1234	tRNA 3'-trailer cleavage
AFK25_09685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFK25_09690	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AFK25_09695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AFK25_09705	COG2195	Cleaves the N-terminal amino acid of tripeptides
AFK25_09710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFK25_09715	COG0346	lactoylglutathione lyase activity
AFK25_09720	COG1376	ErfK ybiS ycfS ynhG family protein
AFK25_09725	COG4129	membrane
AFK25_09735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFK25_09735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFK25_09740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFK25_09745	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFK25_09750	COG0022	dehydrogenase e1 component
AFK25_09755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AFK25_09760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFK25_09765	COG3426	butyrate kinase activity
AFK25_09775	COG0280	phosphate acetyltransferase
AFK25_09780	COG3290	protein histidine kinase activity
AFK25_09780	COG3829	transcription factor binding
AFK25_09790	COG0584	glycerophosphoryl diester phosphodiesterase
AFK25_09800	COG0750	zinc metalloprotease
AFK25_09805	COG0497	DNA recombination
AFK25_09815	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AFK25_09820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFK25_09830	COG1722	exodeoxyribonuclease VII activity
AFK25_09835	COG1570	exodeoxyribonuclease VII activity
AFK25_09840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFK25_09845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFK25_09850	COG1302	Protein conserved in bacteria
AFK25_09855	COG0439	Biotin carboxylase
AFK25_09860	COG0511	ligase activity, forming carbon-carbon bonds
AFK25_09900	COG3854	ATPases associated with a variety of cellular activities
AFK25_09910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFK25_09915	COG0006	proline dipeptidase activity
AFK25_09920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFK25_09930	COG3872	metal-dependent enzyme
AFK25_09940	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFK25_09945	COG1321	iron dependent repressor
AFK25_09955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFK25_09960	COG0095	Lipoate-protein ligase
AFK25_09965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFK25_09975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFK25_09980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFK25_09985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFK25_10020	COG4537	Required for transformation and DNA binding
AFK25_10025	COG4537	Required for transformation and DNA binding
AFK25_10030	COG1459	type II secretion system
AFK25_10035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFK25_10040	COG1393	Belongs to the ArsC family
AFK25_10060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFK25_10075	COG1368	sulfuric ester hydrolase activity
AFK25_10080	COG1940	carbohydrate kinase activity
AFK25_10085	COG4483	Protein conserved in bacteria
AFK25_10090	COG0697	spore germination
AFK25_10100	COG0457	Tetratricopeptide repeat
AFK25_10100	COG0705	Rhomboid family
AFK25_10110	COG0039	L-malate dehydrogenase activity
AFK25_10115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFK25_10120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFK25_10125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AFK25_10140	COG0704	Plays a role in the regulation of phosphate uptake
AFK25_10150	COG0581	inorganic phosphate transmembrane transporter activity
AFK25_10155	COG0573	inorganic phosphate transmembrane transporter activity
AFK25_10160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFK25_10170	COG0477	Major facilitator Superfamily
AFK25_10185	COG5521	maltodextrose utilization protein MalA
AFK25_10190	COG0840	transmembrane signaling receptor activity
AFK25_10200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFK25_10205	COG4709	membrane
AFK25_10210	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AFK25_10215	COG0735	belongs to the Fur family
AFK25_10220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFK25_10225	COG1121	(ABC) transporter
AFK25_10230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AFK25_10240	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AFK25_10255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFK25_10260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFK25_10265	COG2384	SAM-dependent methyltransferase
AFK25_10270	COG2010	Cytochrome c
AFK25_10280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFK25_10290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AFK25_10295	COG0517	IMP dehydrogenase activity
AFK25_10300	COG1381	Involved in DNA repair and RecF pathway recombination
AFK25_10305	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFK25_10310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AFK25_10315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFK25_10320	COG1702	phosphate starvation-inducible protein PhoH
AFK25_10340	COG4864	UPF0365 protein
AFK25_10345	COG1030	water channel activity
AFK25_10350	COG1610	YqeY-like protein
AFK25_10355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFK25_10360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFK25_10365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFK25_10370	COG2264	protein methyltransferase activity
AFK25_10375	COG0484	heat shock protein binding
AFK25_10380	COG0443	Heat shock 70 kDa protein
AFK25_10385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFK25_10390	COG1420	regulation of RNA biosynthetic process
AFK25_10395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFK25_10400	COG0481	GTPase activity
AFK25_10410	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFK25_10415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AFK25_10420	COG0268	Binds directly to 16S ribosomal RNA
AFK25_10425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFK25_10430	COG1466	dna polymerase III delta subunit
AFK25_10440	COG0658	competence protein
AFK25_10440	COG2333	competence protein COMEC
AFK25_10445	COG2131	deaminase
AFK25_10450	COG1596	polysaccharide export
AFK25_10450	COG1555	photosystem II stabilization
AFK25_10455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFK25_10460	COG2226	methyltransferase
AFK25_10465	COG0799	negative regulation of ribosome biogenesis
AFK25_10470	COG1713	HD superfamily hydrolase involved in NAD metabolism
AFK25_10475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFK25_10480	COG1534	Rna-binding protein
AFK25_10485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFK25_10490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AFK25_10495	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AFK25_10505	COG0688	phosphatidylethanolamine metabolic process
AFK25_10510	COG1183	phosphatidylcholine synthase activity
AFK25_10515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFK25_10520	COG1360	Flagellar Motor Protein
AFK25_10525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFK25_10530	COG1191	sigma factor activity
AFK25_10540	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AFK25_10605	COG0626	cystathionine gamma-synthase activity
AFK25_10610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFK25_10615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFK25_10620	COG2226	methyltransferase
AFK25_10635	COG0768	penicillin binding
AFK25_10640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFK25_10645	COG0572	uridine kinase
AFK25_10665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFK25_10670	COG3906	Belongs to the UPF0473 family
AFK25_10675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFK25_10680	COG4472	Bacterial protein of unknown function (DUF965)
AFK25_10685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFK25_10690	COG0628	permease
AFK25_10700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFK25_10710	COG0482	sulfurtransferase activity
AFK25_10715	COG1104	cysteine desulfurase activity
AFK25_10720	COG1959	2 iron, 2 sulfur cluster binding
AFK25_10725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFK25_10730	COG1309	transcriptional regulator
AFK25_10735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFK25_10740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFK25_10745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFK25_10750	COG0124	histidyl-tRNA synthetase
AFK25_10755	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFK25_10765	COG1490	D-aminoacyl-tRNA deacylase activity
AFK25_10770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFK25_10775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFK25_10780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFK25_10780	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AFK25_10785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFK25_10790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFK25_10790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFK25_10800	COG2244	polysaccharide biosynthetic process
AFK25_10805	COG2323	membrane
AFK25_10815	COG1862	Preprotein translocase
AFK25_10820	COG0343	queuine tRNA-ribosyltransferase activity
AFK25_10825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFK25_10835	COG2255	four-way junction helicase activity
AFK25_10840	COG0632	four-way junction helicase activity
AFK25_10850	COG0217	transcriptional regulatory protein
AFK25_10860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFK25_10865	COG2801	Transposase and inactivated derivatives
AFK25_10870	COG1388	LysM domain
AFK25_10875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFK25_10880	COG0157	Belongs to the NadC ModD family
AFK25_10885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFK25_10890	COG1104	cysteine desulfurase activity
AFK25_10895	COG1827	regulation of RNA biosynthetic process
AFK25_10900	COG0077	Prephenate dehydratase
AFK25_10905	COG4492	Belongs to the UPF0735 family
AFK25_10910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFK25_10915	COG3290	protein histidine kinase activity
AFK25_10920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFK25_10925	COG2868	ribosomal protein
AFK25_10930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFK25_10935	COG1994	Peptidase M50
AFK25_10940	COG0739	heme binding
AFK25_10945	COG2894	cell division
AFK25_10950	COG0850	regulation of cytokinetic process
AFK25_10960	COG1792	Involved in formation and maintenance of cell shape
AFK25_10965	COG1077	Cell shape determining protein MreB Mrl
AFK25_10970	COG2003	Belongs to the UPF0758 family
AFK25_11005	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AFK25_11025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFK25_11070	COG0285	dihydrofolate synthase activity
AFK25_11075	COG0525	valine-tRNA ligase activity
AFK25_11085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFK25_11090	COG1388	LysM domain
AFK25_11090	COG1388	LysM domain
AFK25_11095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFK25_11100	COG0113	porphobilinogen synthase activity
AFK25_11105	COG1587	Uroporphyrinogen-III synthase
AFK25_11110	COG0181	hydroxymethylbilane synthase activity
AFK25_11115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFK25_11130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFK25_11140	COG1067	ATP-dependent peptidase activity
AFK25_11140	COG0470	DNA polymerase III
AFK25_11145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFK25_11150	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFK25_11160	COG0066	3-isopropylmalate dehydratase activity
AFK25_11165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFK25_11170	COG0473	3-isopropylmalate dehydrogenase activity
AFK25_11175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFK25_11180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFK25_11185	COG0440	acetolactate synthase activity
AFK25_11190	COG0028	Belongs to the TPP enzyme family
AFK25_11195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFK25_11205	COG0622	Phosphoesterase
AFK25_11210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFK25_11215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFK25_11220	COG5401	PFAM Sporulation and spore germination
AFK25_11225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFK25_11230	COG2197	response regulator
AFK25_11235	COG0824	Thioesterase
AFK25_11240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFK25_11245	COG1053	succinate dehydrogenase
AFK25_11250	COG2009	succinate dehydrogenase
AFK25_11255	COG1719	4-vinyl reductase, 4VR
AFK25_11260	COG0322	excinuclease ABC activity
AFK25_11280	COG1215	transferase activity, transferring glycosyl groups
AFK25_11305	COG3118	belongs to the thioredoxin family
AFK25_11310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFK25_11315	COG2086	electron transfer activity
AFK25_11320	COG1024	Enoyl-CoA hydratase
AFK25_11325	COG1309	transcriptional regulator
AFK25_11330	COG0318	PFAM AMP-dependent synthetase and ligase
AFK25_11335	COG3766	membrane
AFK25_11340	COG1193	negative regulation of DNA recombination
AFK25_11345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFK25_11345	COG1796	DNA polymerase
AFK25_11350	COG1286	toxin biosynthetic process
AFK25_11355	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AFK25_11360	COG2409	Drug exporters of the RND superfamily
AFK25_11360	COG1033	growth of symbiont in host cell
AFK25_11370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFK25_11370	COG0072	phenylalanine-tRNA ligase activity
AFK25_11375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFK25_11380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFK25_11385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFK25_11395	COG1070	Carbohydrate kinase
AFK25_11405	COG5578	integral membrane protein
AFK25_11420	COG1175	transmembrane transport
AFK25_11425	COG1653	transport
AFK25_11430	COG2207	Transcriptional regulator
AFK25_11435	COG2972	Histidine kinase
AFK25_11445	COG0667	Aldo Keto reductase
AFK25_11470	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AFK25_11475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFK25_11480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AFK25_11505	COG1363	Peptidase, m42
AFK25_11515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFK25_11520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFK25_11530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFK25_11540	COG1484	DNA-dependent DNA replication
AFK25_11545	COG3611	Membrane attachment protein
AFK25_11550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFK25_11560	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AFK25_11565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFK25_11575	COG1971	Probably functions as a manganese efflux pump
AFK25_11580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFK25_11590	COG5002	protein histidine kinase activity
AFK25_11595	COG0745	RESPONSE REGULATOR receiver
AFK25_11605	COG0039	L-malate dehydrogenase activity
AFK25_11610	COG0538	isocitrate dehydrogenase activity
AFK25_11615	COG0372	Belongs to the citrate synthase family
AFK25_11620	COG2707	UPF0756 membrane protein
AFK25_11625	COG0628	permease
AFK25_11630	COG3030	protein affecting phage T7 exclusion by the F plasmid
AFK25_11640	COG0205	6-phosphofructokinase activity
AFK25_11645	COG0825	malonyl-CoA metabolic process
AFK25_11650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AFK25_11655	COG1725	Transcriptional regulator
AFK25_11660	COG0281	malic enzyme
AFK25_11665	COG0587	DNA-directed DNA polymerase activity
AFK25_11680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AFK25_11690	COG4109	DRTGG domain
AFK25_11695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFK25_11700	COG0006	proline dipeptidase activity
AFK25_11705	COG1028	Short-chain dehydrogenase reductase Sdr
AFK25_11710	COG0589	response to stress
AFK25_11715	COG0165	Argininosuccinate lyase
AFK25_11720	COG0137	argininosuccinate synthase activity
AFK25_11730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFK25_11735	COG0827	DNA restriction-modification system
AFK25_11740	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AFK25_11745	COG3874	Sporulation protein YtfJ
AFK25_11755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFK25_11770	COG0683	leucine binding
AFK25_11780	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFK25_11795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFK25_11805	COG0301	tRNA thio-modification
AFK25_11810	COG1104	cysteine desulfurase activity
AFK25_11815	COG1114	Component of the transport system for branched-chain amino acids
AFK25_11820	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AFK25_11825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFK25_11830	COG1956	GAF domain-containing protein
AFK25_11835	COG2199	diguanylate cyclase activity
AFK25_11835	COG2203	Gaf domain
AFK25_11840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFK25_11855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFK25_11860	COG0454	-acetyltransferase
AFK25_11865	COG0517	IMP dehydrogenase activity
AFK25_11870	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFK25_11880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFK25_11880	COG1605	Chorismate mutase
AFK25_11885	COG0849	cell division
AFK25_11890	COG2309	aminopeptidase activity
AFK25_11895	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AFK25_11910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFK25_11920	COG1674	ftsk spoiiie
AFK25_11920	COG1674	ftsk spoiiie
AFK25_11925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFK25_11930	COG4848	Belongs to the UPF0354 family
AFK25_11935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK25_11940	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AFK25_11945	COG1363	Peptidase, m42
AFK25_11955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFK25_11960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFK25_11970	COG0510	thiamine kinase activity
AFK25_11975	COG1523	belongs to the glycosyl hydrolase 13 family
AFK25_11990	COG1346	cytolysis
AFK25_11995	COG1380	Effector of murein hydrolase LrgA
AFK25_12010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFK25_12015	COG1349	DNA-binding transcription factor activity
AFK25_12020	COG1187	pseudouridine synthase activity
AFK25_12030	COG2244	polysaccharide biosynthetic process
AFK25_12035	COG2081	HI0933 family
AFK25_12040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFK25_12045	COG0495	leucyl-tRNA aminoacylation
AFK25_12055	COG1242	4 iron, 4 sulfur cluster binding
AFK25_12060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AFK25_12075	COG2267	carboxylic ester hydrolase activity
AFK25_12080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AFK25_12085	COG0671	phosphoesterase, PA-phosphatase related
AFK25_12090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFK25_12095	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AFK25_12130	COG0310	cobalt ion transport
AFK25_12140	COG1122	ATPase activity
AFK25_12155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFK25_12160	COG1116	anion transmembrane transporter activity
AFK25_12165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFK25_12170	COG0494	nUDIX hydrolase
AFK25_12180	COG0783	Belongs to the Dps family
AFK25_12185	COG1854	S-ribosylhomocysteine lyase activity
AFK25_12190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFK25_12195	COG0523	cobalamin synthesis protein
AFK25_12200	COG3443	Belongs to the bacterial solute-binding protein 9 family
AFK25_12200	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFK25_12205	COG1271	oxidase subunit
AFK25_12210	COG1294	oxidase, subunit
AFK25_12215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFK25_12220	COG0716	FMN binding
AFK25_12225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFK25_12250	COG1271	oxidase subunit
AFK25_12255	COG1294	oxidase, subunit
AFK25_12260	COG0318	PFAM AMP-dependent synthetase and ligase
AFK25_12265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AFK25_12270	COG0596	Alpha beta hydrolase
AFK25_12275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AFK25_12280	COG1169	isochorismate synthase
AFK25_12285	COG1575	Belongs to the MenA family. Type 1 subfamily
AFK25_12290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFK25_12295	COG0058	SHG alpha-glucan phosphorylase activity
AFK25_12300	COG0297	glycogen (starch) synthase activity
AFK25_12305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFK25_12310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFK25_12400	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFK25_12455	COG1285	pathogenesis
AFK25_12475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFK25_12490	COG1979	alcohol dehydrogenase
AFK25_12495	COG2155	Conserved Protein
AFK25_12500	COG1098	S1 RNA binding domain
AFK25_12510	COG0436	Aminotransferase
AFK25_12515	COG1522	sequence-specific DNA binding
AFK25_12520	COG2032	superoxide dismutase activity
AFK25_12545	COG1268	BioY protein
AFK25_12550	COG3584	3D domain protein
AFK25_12560	COG1252	NADH dehydrogenase
AFK25_12565	COG0492	ferredoxin-NADP+ reductase activity
AFK25_12570	COG2801	Transposase and inactivated derivatives
AFK25_12575	COG0316	Belongs to the HesB IscA family
AFK25_12580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFK25_12590	COG4844	belongs to the
AFK25_12595	COG1252	NADH dehydrogenase
AFK25_12605	COG4837	Protein of unknown function (DUF1462)
AFK25_12610	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AFK25_12615	COG0083	homoserine kinase activity
AFK25_12620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFK25_12625	COG0460	homoserine dehydrogenase
AFK25_12635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFK25_12640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFK25_12645	COG0647	UMP catabolic process
AFK25_12655	COG2445	Protein of unknown function DUF86
AFK25_12670	COG4470	Protein conserved in bacteria
AFK25_12680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFK25_12685	COG0739	heme binding
AFK25_12690	COG0733	neurotransmitter:sodium symporter activity
AFK25_12700	COG3377	Domain of unknown function (DUF1805)
AFK25_12705	COG0737	Belongs to the 5'-nucleotidase family
AFK25_12710	COG0730	response to heat
AFK25_12715	COG1801	Protein of unknown function DUF72
AFK25_12720	COG0719	Fe-S assembly protein
AFK25_12725	COG0822	iron-sulfur transferase activity
AFK25_12730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFK25_12735	COG0719	Fe-S assembly protein
AFK25_12740	COG0396	ATPase activity
AFK25_12745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFK25_12750	COG1464	Belongs to the NlpA lipoprotein family
AFK25_12755	COG2011	ABC-type metal ion transport system permease component
AFK25_12760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFK25_12775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK25_12780	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AFK25_12790	COG0509	glycine decarboxylation via glycine cleavage system
AFK25_12795	COG1393	Belongs to the ArsC family
AFK25_12800	COG1960	acyl-CoA dehydrogenase activity
AFK25_12805	COG0183	Belongs to the thiolase family
AFK25_12810	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFK25_12810	COG1024	Enoyl-CoA hydratase
AFK25_12815	COG0506	proline dehydrogenase activity
AFK25_12825	COG5577	PFAM Coat F domain
AFK25_12840	COG0748	coenzyme F420 binding
AFK25_12850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK25_12855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFK25_12860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFK25_12865	COG0557	exoribonuclease II activity
AFK25_12875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFK25_12880	COG0148	phosphopyruvate hydratase activity
AFK25_12895	COG0148	phosphopyruvate hydratase activity
AFK25_12900	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFK25_12905	COG0149	triose-phosphate isomerase activity
AFK25_12910	COG0126	phosphoglycerate kinase activity
AFK25_12930	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AFK25_12940	COG0740	serine-type endopeptidase activity
AFK25_12945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK25_12950	COG1481	regulation of sporulation
AFK25_12955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AFK25_12960	COG1660	Displays ATPase and GTPase activities
AFK25_12965	COG1051	belongs to the nudix hydrolase family
AFK25_12970	COG0492	ferredoxin-NADP+ reductase activity
AFK25_12975	COG0457	Tetratricopeptide repeat
AFK25_12980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFK25_12980	COG0140	phosphoribosyl-ATP diphosphatase activity
AFK25_12985	COG0107	imidazoleglycerol-phosphate synthase activity
AFK25_12990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFK25_12995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFK25_13000	COG0131	Imidazoleglycerol-phosphate dehydratase
AFK25_13005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFK25_13010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFK25_13015	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AFK25_13020	COG0110	maltose O-acetyltransferase activity
AFK25_13025	COG0546	phosphoglycolate phosphatase activity
AFK25_13030	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AFK25_13035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFK25_13040	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AFK25_13045	COG1950	PFAM Membrane protein of
AFK25_13060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFK25_13065	COG0556	nucleotide-excision repair
AFK25_13070	COG4897	Protein conserved in bacteria
AFK25_13075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFK25_13080	COG0789	Transcriptional regulator
AFK25_13085	COG0793	Belongs to the peptidase S41A family
AFK25_13085	COG3409	Peptidoglycan-binding domain 1 protein
AFK25_13090	COG0739	heme binding
AFK25_13095	COG2177	Part of the ABC transporter FtsEX involved in
AFK25_13100	COG2884	Cell division ATP-binding protein ftsE
AFK25_13110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AFK25_13125	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFK25_13130	COG0653	protein targeting
AFK25_13150	COG1516	flagellar protein fliS
AFK25_13155	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AFK25_13165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFK25_13170	COG2089	acid synthase
AFK25_13195	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AFK25_13200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFK25_13205	COG1086	Polysaccharide biosynthesis protein
AFK25_13220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFK25_13225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AFK25_13240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFK25_13245	COG4786	Flagellar basal body rod
AFK25_13245	COG1256	bacterial-type flagellum assembly
AFK25_13285	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AFK25_13290	COG1307	EDD domain protein, DegV family
AFK25_13295	COG2197	response regulator
AFK25_13300	COG4585	Histidine kinase
AFK25_13305	COG1739	Uncharacterized protein family UPF0029
AFK25_13310	COG1316	TRANSCRIPTIONal
AFK25_13315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFK25_13325	COG2247	cell wall binding repeat
AFK25_13325	COG2385	sporulation resulting in formation of a cellular spore
AFK25_13340	COG1404	Belongs to the peptidase S8 family
AFK25_13345	COG0737	Belongs to the 5'-nucleotidase family
AFK25_13410	COG1073	alpha beta
AFK25_13500	COG0791	NLP P60 protein
AFK25_13500	COG1388	LysM domain
AFK25_13510	COG1404	Belongs to the peptidase S8 family
AFK25_13515	COG0653	protein targeting
AFK25_13530	COG3620	sequence-specific DNA binding
AFK25_13560	COG0527	aspartate kinase activity
AFK25_13575	COG0840	transmembrane signaling receptor activity
AFK25_13590	COG2244	polysaccharide biosynthetic process
AFK25_13605	COG3012	SEC-C Motif Domain Protein
AFK25_13605	COG1405	negative regulation of cell septum assembly
AFK25_13610	COG2996	Protein conserved in bacteria
AFK25_13615	COG0673	inositol 2-dehydrogenase activity
AFK25_13630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFK25_13640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFK25_13645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFK25_13650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFK25_13655	COG3012	SEC-C Motif Domain Protein
AFK25_13660	COG2610	gluconate transmembrane transporter activity
AFK25_13665	COG1070	Carbohydrate kinase
AFK25_13670	COG1609	Transcriptional regulator
AFK25_13700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFK25_13705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFK25_13720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFK25_13730	COG4786	Flagellar basal body rod
AFK25_13735	COG4786	Flagellar basal body rod
AFK25_13740	COG1077	Cell shape determining protein MreB Mrl
AFK25_13745	COG1609	Transcriptional regulator
AFK25_13750	COG0739	heme binding
AFK25_13755	COG2385	sporulation resulting in formation of a cellular spore
AFK25_13760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFK25_13770	COG4836	Membrane
AFK25_13775	COG1007	ATP synthesis coupled electron transport
AFK25_13785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFK25_13790	COG0713	ATP synthesis coupled electron transport
AFK25_13795	COG0839	Belongs to the complex I subunit 6 family
AFK25_13800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFK25_13805	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFK25_13810	COG0649	NAD binding
AFK25_13815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFK25_13820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFK25_13825	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFK25_13830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFK25_13835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFK25_13840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFK25_13845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFK25_13850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFK25_13855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFK25_13860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFK25_13865	COG0356	it plays a direct role in the translocation of protons across the membrane
AFK25_13880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AFK25_13885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AFK25_13890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFK25_13895	COG4475	Protein of unknown function (DUF436)
AFK25_13900	COG0698	ribose 5-phosphate isomerase
AFK25_13905	COG0840	transmembrane signaling receptor activity
AFK25_13915	COG1971	Probably functions as a manganese efflux pump
AFK25_13920	COG0009	L-threonylcarbamoyladenylate synthase
AFK25_13935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFK25_13940	COG1435	thymidine kinase activity
AFK25_13945	COG0254	rRNA binding
AFK25_13950	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AFK25_13955	COG1494	fructose-1,6-bisphosphatase
AFK25_13960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFK25_13965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFK25_13975	COG2204	response regulator
AFK25_13985	COG0504	CTP synthase activity
AFK25_13990	COG3343	RNA polymerase activity
AFK25_13995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFK25_13995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFK25_13995	COG1703	isobutyryl-CoA mutase activity
AFK25_14005	COG1960	acyl-CoA dehydrogenase activity
AFK25_14010	COG1960	acyl-CoA dehydrogenase activity
AFK25_14015	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFK25_14020	COG0183	Belongs to the thiolase family
AFK25_14025	COG0247	lactate metabolic process
AFK25_14025	COG2181	nitrate reductase activity
AFK25_14030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFK25_14035	COG0018	arginyl-trna synthetase
AFK25_14050	COG0010	Belongs to the arginase family
AFK25_14055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFK25_14060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFK25_14070	COG1994	Peptidase M50
AFK25_14080	COG3465	dGTPase activity
AFK25_14085	COG1078	dGTPase activity
AFK25_14090	COG4844	belongs to the
AFK25_14110	COG0095	Lipoate-protein ligase
AFK25_14115	COG0280	phosphate acetyltransferase
AFK25_14120	COG1238	metal cluster binding
AFK25_14130	COG3773	Cell wall hydrolase
AFK25_14140	COG2363	Small membrane protein
AFK25_14155	COG0475	glutathione-regulated potassium exporter activity
AFK25_14155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFK25_14165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFK25_14170	COG0423	glycine-tRNA ligase activity
AFK25_14175	COG3634	alkyl hydroperoxide reductase activity
AFK25_14180	COG0450	alkyl hydroperoxide reductase
AFK25_14190	COG1216	Glycosyl transferase, family 2
AFK25_14195	COG0477	Major facilitator Superfamily
AFK25_14200	COG0295	cytidine deaminase activity
AFK25_14210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AFK25_14215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AFK25_14220	COG2390	Transcriptional regulator
AFK25_14225	COG1621	beta-fructofuranosidase activity
AFK25_14230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFK25_14235	COG1263	PTS System
AFK25_14235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK25_14240	COG3711	transcriptional antiterminator
AFK25_14245	COG2190	(PTS) system
AFK25_14250	COG2508	Transcriptional regulator
AFK25_14250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AFK25_14255	COG0686	Belongs to the AlaDH PNT family
AFK25_14280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AFK25_14285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFK25_14290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFK25_14295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFK25_14305	COG1595	DNA-templated transcription, initiation
AFK25_14315	COG1136	(ABC) transporter
AFK25_14315	COG0577	efflux transmembrane transporter activity
AFK25_14335	COG1131	(ABC) transporter
AFK25_14365	COG4585	Histidine kinase
AFK25_14375	COG1131	(ABC) transporter
AFK25_14395	COG1012	belongs to the aldehyde dehydrogenase family
AFK25_14395	COG1454	alcohol dehydrogenase
AFK25_14410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFK25_14410	COG0723	plastoquinol--plastocyanin reductase activity
AFK25_14415	COG0697	spore germination
AFK25_14430	COG3842	ATPase activity
AFK25_14435	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFK25_14440	COG1177	transmembrane transport
AFK25_14445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AFK25_14450	COG3104	oligopeptide transport
AFK25_14455	COG2003	Belongs to the UPF0758 family
AFK25_14460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFK25_14495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AFK25_14495	COG0116	Belongs to the methyltransferase superfamily
AFK25_14515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFK25_14520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AFK25_14525	COG4853	Protein conserved in bacteria
AFK25_14535	COG5002	protein histidine kinase activity
AFK25_14540	COG0745	RESPONSE REGULATOR receiver
AFK25_14555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFK25_14560	COG0305	Participates in initiation and elongation during chromosome replication
AFK25_14565	COG0359	binds to the 23S rRNA
AFK25_14570	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AFK25_14575	COG4241	membrane
AFK25_14580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFK25_14585	COG0629	single-stranded DNA binding
AFK25_14590	COG0360	Binds together with S18 to 16S ribosomal RNA
AFK25_14595	COG0012	GTP binding
AFK25_14600	COG4481	Protein conserved in bacteria
AFK25_14605	COG0668	transmembrane transport
AFK25_14620	COG1475	DNA binding
AFK25_14625	COG1192	Involved in chromosome partitioning
AFK25_14630	COG1475	DNA binding
AFK25_14635	COG0357	Ribosomal RNA small subunit methyltransferase G
AFK25_14640	COG0445	tRNA wobble uridine modification
AFK25_14645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFK25_14650	COG1847	R3H domain protein
AFK25_14655	COG0706	membrane insertase activity
AFK25_14660	COG0594	ribonuclease P activity
AFK25_14665	COG0230	Belongs to the bacterial ribosomal protein bL34 family