locus-tag	class	description
IRT44_00015	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IRT44_00035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_00040	COG1253	flavin adenine dinucleotide binding
IRT44_00045	COG0210	DNA helicase
IRT44_00050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IRT44_00075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_00080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IRT44_00090	COG0835	chemotaxis
IRT44_00110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IRT44_00125	COG0477	Major facilitator Superfamily
IRT44_00125	COG2814	Major facilitator Superfamily
IRT44_00130	COG1116	anion transmembrane transporter activity
IRT44_00130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRT44_00135	COG4120	Belongs to the binding-protein-dependent transport system permease family
IRT44_00150	COG1253	flavin adenine dinucleotide binding
IRT44_00160	COG1595	DNA-templated transcription, initiation
IRT44_00170	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IRT44_00185	COG2211	Major facilitator Superfamily
IRT44_00190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_00200	COG1902	pentaerythritol trinitrate reductase activity
IRT44_00200	COG0446	pyridine nucleotide-disulphide oxidoreductase
IRT44_00215	COG1316	TRANSCRIPTIONal
IRT44_00225	COG2223	nitrite transmembrane transporter activity
IRT44_00230	COG3012	SEC-C Motif Domain Protein
IRT44_00230	COG1405	negative regulation of cell septum assembly
IRT44_00245	COG3481	metal-dependent phosphohydrolase, HD sub domain
IRT44_00270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IRT44_00275	COG0024	Methionine aminopeptidase
IRT44_00295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IRT44_00300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IRT44_00305	COG0179	Fumarylacetoacetate (FAA) hydrolase
IRT44_00310	COG0564	pseudouridine synthase activity
IRT44_00320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IRT44_00335	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IRT44_00345	COG3874	Sporulation protein YtfJ
IRT44_00355	COG3584	3D domain protein
IRT44_00355	COG1388	LysM domain
IRT44_00360	COG1376	ErfK ybiS ycfS ynhG family protein
IRT44_00375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRT44_00385	COG2323	membrane
IRT44_00405	COG0726	polysaccharide deacetylase
IRT44_00410	COG0861	Integral membrane protein TerC family
IRT44_00415	COG4191	Histidine kinase
IRT44_00520	COG2801	Transposase and inactivated derivatives
IRT44_00525	COG0179	Fumarylacetoacetate (FAA) hydrolase
IRT44_00530	COG0301	tRNA thio-modification
IRT44_00535	COG1104	cysteine desulfurase activity
IRT44_00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IRT44_00560	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
IRT44_00570	COG0300	oxidoreductase activity
IRT44_00590	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IRT44_00595	COG4326	sporulation control protein
IRT44_00615	COG2211	Major facilitator Superfamily
IRT44_00625	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRT44_00625	COG2199	diguanylate cyclase activity
IRT44_00635	COG1363	Peptidase, m42
IRT44_00645	COG2081	HI0933 family
IRT44_00650	COG3344	reverse transcriptase
IRT44_00660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IRT44_00665	COG1309	transcriptional regulator
IRT44_00675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_00680	COG2199	diguanylate cyclase activity
IRT44_00680	COG2203	Gaf domain
IRT44_00695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IRT44_00705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IRT44_00710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRT44_00715	COG0454	-acetyltransferase
IRT44_00720	COG0517	IMP dehydrogenase activity
IRT44_00725	COG0123	including yeast histone deacetylase and acetoin utilization protein
IRT44_00730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IRT44_00745	COG1605	Chorismate mutase
IRT44_00745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IRT44_00755	COG3118	belongs to the thioredoxin family
IRT44_00775	COG2309	aminopeptidase activity
IRT44_00780	COG1695	Transcriptional regulator
IRT44_00790	COG1733	regulation of RNA biosynthetic process
IRT44_00795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRT44_00800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRT44_00825	COG3344	reverse transcriptase
IRT44_00830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_00840	COG0436	Aminotransferase
IRT44_00845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_00855	COG1846	Transcriptional regulator
IRT44_00860	COG2814	Major facilitator Superfamily
IRT44_00865	COG0315	cyclic pyranopterin monophosphate synthase activity
IRT44_00870	COG0314	molybdopterin synthase activity
IRT44_00875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IRT44_00880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IRT44_00910	COG1414	Transcriptional regulator
IRT44_00915	COG0656	L-ascorbic acid biosynthetic process
IRT44_00935	COG0697	spore germination
IRT44_00945	COG0681	Belongs to the peptidase S26 family
IRT44_00955	COG1674	ftsk spoiiie
IRT44_00965	COG0529	Catalyzes the synthesis of activated sulfate
IRT44_00970	COG2046	Belongs to the sulfate adenylyltransferase family
IRT44_00975	COG0175	sulfate reduction
IRT44_00980	COG1587	Uroporphyrinogen-III synthase
IRT44_00980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRT44_00990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IRT44_01000	COG0483	inositol monophosphate 1-phosphatase activity
IRT44_01015	COG0129	dihydroxy-acid dehydratase activity
IRT44_01020	COG4948	Mandelate Racemase Muconate Lactonizing
IRT44_01030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IRT44_01035	COG3344	reverse transcriptase
IRT44_01060	COG1376	ErfK ybiS ycfS ynhG family protein
IRT44_01070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRT44_01090	COG5002	protein histidine kinase activity
IRT44_01100	COG0586	Pfam SNARE associated Golgi protein
IRT44_01125	COG0488	(ABC) transporter
IRT44_01145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRT44_01150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRT44_01155	COG0765	amino acid transport
IRT44_01160	COG1126	abc transporter atp-binding protein
IRT44_01170	COG3387	PFAM Glycoside hydrolase 15-related
IRT44_01175	COG0395	ABC-type sugar transport system, permease component
IRT44_01180	COG1175	transmembrane transport
IRT44_01190	COG1609	Transcriptional regulator
IRT44_01200	COG0483	inositol monophosphate 1-phosphatase activity
IRT44_01210	COG1966	Carbon starvation protein
IRT44_01215	COG3279	Response regulator of the LytR AlgR family
IRT44_01220	COG3275	phosphorelay sensor kinase activity
IRT44_01225	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IRT44_01245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IRT44_01245	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IRT44_01255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_01260	COG2357	RelA SpoT domain protein
IRT44_01280	COG0826	peptidase U32
IRT44_01285	COG4840	Belongs to the UPF0435 family
IRT44_01300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_01310	COG0189	ligase activity
IRT44_01315	COG1473	amidohydrolase
IRT44_01325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IRT44_01340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_01350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_01355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_01360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IRT44_01365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IRT44_01370	COG0697	spore germination
IRT44_01375	COG0531	amino acid
IRT44_01390	COG0531	amino acid
IRT44_01400	COG0640	Transcriptional regulator
IRT44_01405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IRT44_01405	COG1918	ferrous iron import across plasma membrane
IRT44_01410	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IRT44_01415	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IRT44_01430	COG4214	carbohydrate transport
IRT44_01435	COG1129	ABC transporter
IRT44_01450	COG1454	alcohol dehydrogenase
IRT44_01455	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_01460	COG1609	Transcriptional regulator
IRT44_01470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRT44_01495	COG2267	carboxylic ester hydrolase activity
IRT44_01500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IRT44_01505	COG1177	transmembrane transport
IRT44_01510	COG1176	ABC-type spermidine putrescine transport system, permease component I
IRT44_01520	COG1695	Transcriptional regulator
IRT44_01525	COG1879	ABC-type sugar transport system periplasmic component
IRT44_01530	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRT44_01535	COG1129	ABC transporter
IRT44_01540	COG1869	D-ribose catabolic process
IRT44_01545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_01550	COG1609	Transcriptional regulator
IRT44_01555	COG1556	Lactate utilization protein
IRT44_01560	COG1139	Iron-sulfur cluster binding protein
IRT44_01565	COG0247	lactate metabolic process
IRT44_01570	COG2186	Transcriptional regulator
IRT44_01575	COG1620	l-lactate permease
IRT44_01585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IRT44_01590	COG0454	-acetyltransferase
IRT44_01600	COG2070	2-Nitropropane dioxygenase
IRT44_01605	COG0494	nUDIX hydrolase
IRT44_01620	COG2971	BadF BadG BcrA BcrD
IRT44_01625	COG0165	Argininosuccinate lyase
IRT44_01630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRT44_01640	COG3842	ATPase activity
IRT44_01645	COG1840	ABC-type Fe3 transport system, periplasmic component
IRT44_01660	COG0840	transmembrane signaling receptor activity
IRT44_01670	COG3253	May function as heme-dependent peroxidase
IRT44_01675	COG0363	glucosamine-6-phosphate deaminase activity
IRT44_01680	COG1737	Transcriptional regulator
IRT44_01690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRT44_01695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRT44_01700	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_01705	COG1940	carbohydrate kinase activity
IRT44_01715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRT44_01720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRT44_01725	COG1085	galactose-1-phosphate uridylyltransferase
IRT44_01730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IRT44_01740	COG3142	Participates in the control of copper homeostasis
IRT44_01745	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IRT44_01750	COG0720	synthase
IRT44_01760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IRT44_01770	COG2084	Dehydrogenase
IRT44_01780	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_01795	COG1376	ErfK ybiS ycfS ynhG family protein
IRT44_01805	COG1116	anion transmembrane transporter activity
IRT44_01810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRT44_01815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IRT44_01820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRT44_01840	COG5002	protein histidine kinase activity
IRT44_01845	COG0745	RESPONSE REGULATOR receiver
IRT44_01870	COG2011	ABC-type metal ion transport system permease component
IRT44_01890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRT44_01895	COG1832	CoA-binding protein
IRT44_01900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IRT44_01910	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IRT44_01915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_01920	COG3584	3D domain protein
IRT44_01940	COG1252	NADH dehydrogenase
IRT44_01975	COG0316	Belongs to the HesB IscA family
IRT44_01985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IRT44_01995	COG1252	NADH dehydrogenase
IRT44_02000	COG2801	Transposase and inactivated derivatives
IRT44_02015	COG4837	Protein of unknown function (DUF1462)
IRT44_02020	COG0626	cystathionine gamma-synthase activity
IRT44_02025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRT44_02030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IRT44_02040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRT44_02050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IRT44_02065	COG2445	Protein of unknown function DUF86
IRT44_02075	COG1494	fructose-1,6-bisphosphatase
IRT44_02085	COG4470	Protein conserved in bacteria
IRT44_02105	COG0420	3'-5' exonuclease activity
IRT44_02110	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IRT44_02120	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IRT44_02125	COG0739	heme binding
IRT44_02140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRT44_02140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRT44_02150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IRT44_02150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IRT44_02165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IRT44_02165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IRT44_02170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IRT44_02175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_02180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IRT44_02185	COG1802	Transcriptional regulator
IRT44_02190	COG0346	lactoylglutathione lyase activity
IRT44_02195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IRT44_02200	COG0840	transmembrane signaling receptor activity
IRT44_02210	COG0598	Magnesium transport protein CorA
IRT44_02220	COG3377	Domain of unknown function (DUF1805)
IRT44_02230	COG0737	Belongs to the 5'-nucleotidase family
IRT44_02235	COG0730	response to heat
IRT44_02240	COG1801	Protein of unknown function DUF72
IRT44_02260	COG0697	spore germination
IRT44_02265	COG2268	Band 7 protein
IRT44_02270	COG1585	Membrane protein implicated in regulation of membrane protease activity
IRT44_02275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_02280	COG0697	spore germination
IRT44_02285	COG1363	Peptidase, m42
IRT44_02340	COG0719	Fe-S assembly protein
IRT44_02345	COG0822	iron-sulfur transferase activity
IRT44_02350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRT44_02355	COG0719	Fe-S assembly protein
IRT44_02360	COG0396	ATPase activity
IRT44_02365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IRT44_02370	COG1473	amidohydrolase
IRT44_02390	COG0509	glycine decarboxylation via glycine cleavage system
IRT44_02395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_02400	COG0450	alkyl hydroperoxide reductase
IRT44_02405	COG0436	Aminotransferase
IRT44_02410	COG1393	Belongs to the ArsC family
IRT44_02430	COG1126	abc transporter atp-binding protein
IRT44_02445	COG0477	Major facilitator Superfamily
IRT44_02450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRT44_02455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IRT44_02460	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IRT44_02470	COG1595	DNA-templated transcription, initiation
IRT44_02480	COG1850	ribulose-bisphosphate carboxylase activity
IRT44_02485	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
IRT44_02490	COG0235	Class ii aldolase
IRT44_02495	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IRT44_02500	COG1960	acyl-CoA dehydrogenase activity
IRT44_02505	COG0183	Belongs to the thiolase family
IRT44_02510	COG1024	Enoyl-CoA hydratase
IRT44_02510	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRT44_02525	COG1131	(ABC) transporter
IRT44_02545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRT44_02560	COG5577	PFAM Coat F domain
IRT44_02565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_02570	COG1279	arginine transmembrane transporter activity
IRT44_02605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IRT44_02615	COG1122	ATPase activity
IRT44_02625	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
IRT44_02630	COG0310	cobalt ion transport
IRT44_02635	COG0167	dihydroorotate dehydrogenase activity
IRT44_02660	COG0686	Belongs to the AlaDH PNT family
IRT44_02665	COG2508	Transcriptional regulator
IRT44_02665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IRT44_02670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRT44_02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRT44_02680	COG0022	dehydrogenase e1 component
IRT44_02685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IRT44_02690	COG0095	Lipoate-protein ligase
IRT44_02695	COG3284	Transcriptional regulator
IRT44_02700	COG2201	protein-glutamate methylesterase activity
IRT44_02715	COG4191	Histidine kinase
IRT44_02720	COG1506	peptidase
IRT44_02725	COG1098	S1 RNA binding domain
IRT44_02735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IRT44_02745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IRT44_02770	COG1280	lysine exporter protein (LysE YggA)
IRT44_02775	COG0788	formyltetrahydrofolate deformylase activity
IRT44_02790	COG3852	Histidine kinase
IRT44_02800	COG1309	transcriptional regulator
IRT44_02805	COG0842	Transport permease protein
IRT44_02810	COG1131	(ABC) transporter
IRT44_02815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_02820	COG0531	amino acid
IRT44_02830	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IRT44_02835	COG0419	ATPase involved in DNA repair
IRT44_02845	COG1612	heme a metabolic process
IRT44_02850	COG0109	protoheme IX farnesyltransferase activity
IRT44_02860	COG3336	cytochrome c oxidase
IRT44_02880	COG2010	Cytochrome c
IRT44_02880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IRT44_02890	COG2814	Major facilitator Superfamily
IRT44_02895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRT44_02905	COG4667	esterase of the alpha-beta hydrolase superfamily
IRT44_02920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IRT44_02940	COG0714	Associated with various cellular activities
IRT44_02955	COG1131	(ABC) transporter
IRT44_02970	COG2076	Multidrug Resistance protein
IRT44_02980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRT44_02995	COG0789	Transcriptional regulator
IRT44_03000	COG3359	exonuclease
IRT44_03005	COG1111	helicase
IRT44_03005	COG1205	dead DEAH box helicase
IRT44_03010	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_03025	COG0517	IMP dehydrogenase activity
IRT44_03025	COG4175	Glycine betaine
IRT44_03030	COG1510	regulation of RNA biosynthetic process
IRT44_03035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IRT44_03040	COG4607	ABC-type enterochelin transport system periplasmic component
IRT44_03045	COG4604	ABC transporter, ATP-binding protein
IRT44_03050	COG4605	iron ion homeostasis
IRT44_03055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_03085	COG0577	efflux transmembrane transporter activity
IRT44_03085	COG1136	(ABC) transporter
IRT44_03090	COG1136	(ABC) transporter
IRT44_03095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_03105	COG5002	protein histidine kinase activity
IRT44_03115	COG0840	transmembrane signaling receptor activity
IRT44_03120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_03125	COG2132	Multicopper oxidase
IRT44_03135	COG1846	Transcriptional regulator
IRT44_03165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IRT44_03170	COG0557	exoribonuclease II activity
IRT44_03175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IRT44_03185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRT44_03195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_03200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_03205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_03215	COG0148	phosphopyruvate hydratase activity
IRT44_03220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IRT44_03225	COG0149	triose-phosphate isomerase activity
IRT44_03230	COG0126	phosphoglycerate kinase activity
IRT44_03240	COG1757	Na H antiporter
IRT44_03255	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IRT44_03295	COG0740	serine-type endopeptidase activity
IRT44_03310	COG1660	Displays ATPase and GTPase activities
IRT44_03315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_03320	COG1481	regulation of sporulation
IRT44_03325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IRT44_03330	COG1660	Displays ATPase and GTPase activities
IRT44_03335	COG0492	ferredoxin-NADP+ reductase activity
IRT44_03390	COG2358	TRAP transporter, solute receptor (TAXI family
IRT44_03395	COG2204	response regulator
IRT44_03400	COG3852	Histidine kinase
IRT44_03410	COG0140	phosphoribosyl-ATP diphosphatase activity
IRT44_03410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IRT44_03415	COG0107	imidazoleglycerol-phosphate synthase activity
IRT44_03420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IRT44_03425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IRT44_03430	COG0131	Imidazoleglycerol-phosphate dehydratase
IRT44_03435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IRT44_03440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IRT44_03445	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IRT44_03450	COG0110	maltose O-acetyltransferase activity
IRT44_03455	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IRT44_03460	COG3290	protein histidine kinase activity
IRT44_03470	COG1418	mRNA catabolic process
IRT44_03475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IRT44_03480	COG0556	nucleotide-excision repair
IRT44_03485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IRT44_03495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRT44_03500	COG0793	Belongs to the peptidase S41A family
IRT44_03500	COG3409	Peptidoglycan-binding domain 1 protein
IRT44_03505	COG0739	heme binding
IRT44_03510	COG2177	Part of the ABC transporter FtsEX involved in
IRT44_03515	COG2884	Cell division ATP-binding protein ftsE
IRT44_03520	COG1979	alcohol dehydrogenase
IRT44_03525	COG3344	reverse transcriptase
IRT44_03530	COG0165	Argininosuccinate lyase
IRT44_03535	COG0137	argininosuccinate synthase activity
IRT44_03545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRT44_03545	COG2199	diguanylate cyclase activity
IRT44_03555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IRT44_03560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IRT44_03565	COG0505	Belongs to the CarA family
IRT44_03570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRT44_03575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IRT44_03580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IRT44_03605	COG0653	protein targeting
IRT44_03610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IRT44_03615	COG1278	Cold shock
IRT44_03620	COG0765	amino acid transport
IRT44_03650	COG3344	reverse transcriptase
IRT44_03665	COG1516	flagellar protein fliS
IRT44_03670	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IRT44_03675	COG1334	flagellar protein FlaG
IRT44_03680	COG0463	Glycosyl transferase, family 2
IRT44_03685	COG0457	Tetratricopeptide repeat
IRT44_03685	COG0463	Glycosyl transferase, family 2
IRT44_03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRT44_03695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IRT44_03700	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IRT44_03710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRT44_03715	COG4786	Flagellar basal body rod
IRT44_03715	COG1256	bacterial-type flagellum assembly
IRT44_03740	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IRT44_03750	COG2197	response regulator
IRT44_03760	COG0726	polysaccharide deacetylase
IRT44_03760	COG1649	PFAM Uncharacterised BCR, COG1649
IRT44_03765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IRT44_03775	COG1404	Belongs to the peptidase S8 family
IRT44_03800	COG0667	Aldo Keto reductase
IRT44_03805	COG0840	transmembrane signaling receptor activity
IRT44_03840	COG3209	COG3209 Rhs family protein
IRT44_03855	COG3209	COG3209 Rhs family protein
IRT44_03865	COG3209	COG3209 Rhs family protein
IRT44_03875	COG3209	COG3209 Rhs family protein
IRT44_03915	COG0544	peptidyl-prolyl cis-trans isomerase activity
IRT44_03930	COG1739	Uncharacterized protein family UPF0029
IRT44_03945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRT44_03955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IRT44_03975	COG4786	Flagellar basal body rod
IRT44_03985	COG1609	Transcriptional regulator
IRT44_03990	COG0739	heme binding
IRT44_03995	COG2385	sporulation resulting in formation of a cellular spore
IRT44_04000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRT44_04010	COG4836	Membrane
IRT44_04015	COG1007	ATP synthesis coupled electron transport
IRT44_04025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IRT44_04030	COG0713	ATP synthesis coupled electron transport
IRT44_04035	COG0839	Belongs to the complex I subunit 6 family
IRT44_04040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRT44_04045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IRT44_04050	COG0649	NAD binding
IRT44_04055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRT44_04060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRT44_04065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRT44_04075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IRT44_04080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IRT44_04085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IRT44_04090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IRT44_04095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IRT44_04100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IRT44_04110	COG0356	it plays a direct role in the translocation of protons across the membrane
IRT44_04130	COG4106	trans-aconitate 2-methyltransferase activity
IRT44_04145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IRT44_04155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IRT44_04160	COG1361	Conserved repeat domain
IRT44_04165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IRT44_04170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IRT44_04180	COG2801	Transposase and inactivated derivatives
IRT44_04190	COG4475	Protein of unknown function (DUF436)
IRT44_04195	COG0698	ribose 5-phosphate isomerase
IRT44_04205	COG1971	Probably functions as a manganese efflux pump
IRT44_04210	COG0009	L-threonylcarbamoyladenylate synthase
IRT44_04220	COG2890	protein-(glutamine-N5) methyltransferase activity
IRT44_04225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IRT44_04240	COG0254	rRNA binding
IRT44_04250	COG0739	heme binding
IRT44_04255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IRT44_04260	COG1494	fructose-1,6-bisphosphatase
IRT44_04265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRT44_04270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IRT44_04275	COG0191	fructose-bisphosphate aldolase activity
IRT44_04290	COG0504	CTP synthase activity
IRT44_04295	COG3343	RNA polymerase activity
IRT44_04300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IRT44_04305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRT44_04310	COG1703	isobutyryl-CoA mutase activity
IRT44_04310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRT44_04310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRT44_04315	COG1309	transcriptional regulator
IRT44_04325	COG1960	acyl-CoA dehydrogenase activity
IRT44_04330	COG1960	acyl-CoA dehydrogenase activity
IRT44_04335	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRT44_04340	COG0183	Belongs to the thiolase family
IRT44_04360	COG2181	nitrate reductase activity
IRT44_04360	COG0247	lactate metabolic process
IRT44_04365	COG1509	lysine 2,3-aminomutase activity
IRT44_04370	COG3829	transcription factor binding
IRT44_04395	COG0010	Belongs to the arginase family
IRT44_04400	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRT44_04405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRT44_04445	COG3465	dGTPase activity
IRT44_04450	COG1078	dGTPase activity
IRT44_04495	COG3391	amine dehydrogenase activity
IRT44_04500	COG0564	pseudouridine synthase activity
IRT44_04540	COG0116	Belongs to the methyltransferase superfamily
IRT44_04550	COG1564	THIamine pyrophosphokinase
IRT44_04555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IRT44_04565	COG2249	NAD(P)H dehydrogenase (quinone) activity
IRT44_04575	COG1309	transcriptional regulator
IRT44_04585	COG0405	Gamma-glutamyltransferase
IRT44_04590	COG0840	transmembrane signaling receptor activity
IRT44_04595	COG0584	glycerophosphoryl diester phosphodiesterase
IRT44_04605	COG0395	ABC-type sugar transport system, permease component
IRT44_04610	COG1175	transmembrane transport
IRT44_04620	COG2801	Transposase and inactivated derivatives
IRT44_04630	COG0813	purine-nucleoside phosphorylase activity
IRT44_04635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRT44_04640	COG1079	Belongs to the binding-protein-dependent transport system permease family
IRT44_04645	COG4603	Belongs to the binding-protein-dependent transport system permease family
IRT44_04650	COG3845	ABC transporter
IRT44_04655	COG1744	ABC transporter substrate-binding protein PnrA-like
IRT44_04670	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_04675	COG2610	gluconate transmembrane transporter activity
IRT44_04680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IRT44_04685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IRT44_04690	COG0667	Aldo Keto reductase
IRT44_04700	COG2814	Major facilitator Superfamily
IRT44_04705	COG1733	regulation of RNA biosynthetic process
IRT44_04710	COG3290	protein histidine kinase activity
IRT44_04710	COG3829	transcription factor binding
IRT44_04715	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IRT44_04725	COG1131	(ABC) transporter
IRT44_04740	COG1115	amino acid carrier protein
IRT44_04745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_04755	COG0246	Mannitol dehydrogenase
IRT44_04765	COG3711	transcriptional antiterminator
IRT44_04775	COG0584	glycerophosphoryl diester phosphodiesterase
IRT44_04785	COG0500	methyltransferase
IRT44_04800	COG5002	protein histidine kinase activity
IRT44_04810	COG5002	protein histidine kinase activity
IRT44_04820	COG0204	Acyl-transferase
IRT44_04820	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_04825	COG2814	Major facilitator Superfamily
IRT44_04830	COG0534	Mate efflux family protein
IRT44_04840	COG1132	(ABC) transporter
IRT44_04845	COG1132	(ABC) transporter
IRT44_04850	COG1120	ATPase activity
IRT44_04855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_04860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_04875	COG3037	sugar-specific permease SgaT UlaA
IRT44_04885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_04890	COG0579	oxidoreductase
IRT44_04915	COG2814	Major facilitator Superfamily
IRT44_04920	COG2814	Major facilitator Superfamily
IRT44_04930	COG1309	transcriptional regulator
IRT44_04940	COG0640	Transcriptional regulator
IRT44_04985	COG2378	regulation of single-species biofilm formation
IRT44_05000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IRT44_05015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRT44_05025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IRT44_05030	COG4853	Protein conserved in bacteria
IRT44_05040	COG5002	protein histidine kinase activity
IRT44_05045	COG0745	RESPONSE REGULATOR receiver
IRT44_05050	COG0741	lytic transglycosylase activity
IRT44_05050	COG1196	nuclear chromosome segregation
IRT44_05050	COG0739	heme binding
IRT44_05065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IRT44_05075	COG0359	binds to the 23S rRNA
IRT44_05080	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IRT44_05090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IRT44_05095	COG0629	single-stranded DNA binding
IRT44_05100	COG0360	Binds together with S18 to 16S ribosomal RNA
IRT44_05105	COG0012	GTP binding
IRT44_05110	COG1164	Oligoendopeptidase f
IRT44_05120	COG4481	Protein conserved in bacteria
IRT44_05125	COG0668	transmembrane transport
IRT44_05140	COG1597	lipid kinase activity
IRT44_05145	COG0640	Transcriptional regulator
IRT44_05150	COG0697	spore germination
IRT44_05165	COG1811	Na channel or pump
IRT44_05170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRT44_05175	COG1475	DNA binding
IRT44_05180	COG1192	Involved in chromosome partitioning
IRT44_05185	COG1475	DNA binding
IRT44_05195	COG0357	Ribosomal RNA small subunit methyltransferase G
IRT44_05200	COG0445	tRNA wobble uridine modification
IRT44_05205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IRT44_05215	COG1847	R3H domain protein
IRT44_05220	COG0706	membrane insertase activity
IRT44_05225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IRT44_05230	COG0594	ribonuclease P activity
IRT44_05235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IRT44_05245	COG0592	DNA-directed DNA polymerase activity
IRT44_05250	COG2501	S4 domain
IRT44_05255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IRT44_05265	COG0187	DNA topoisomerase II activity
IRT44_05270	COG2814	Major facilitator Superfamily
IRT44_05280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRT44_05285	COG3437	response regulator, receiver
IRT44_05310	COG0516	GMP reductase activity
IRT44_05310	COG0517	IMP dehydrogenase activity
IRT44_05325	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IRT44_05330	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IRT44_05335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IRT44_05345	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IRT44_05350	COG2224	Isocitrate lyase
IRT44_05395	COG1733	regulation of RNA biosynthetic process
IRT44_05425	COG1263	PTS System
IRT44_05425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRT44_05430	COG2190	(PTS) system
IRT44_05435	COG3711	transcriptional antiterminator
IRT44_05445	COG2318	DinB family
IRT44_05455	COG0590	tRNA wobble adenosine to inosine editing
IRT44_05460	COG1187	pseudouridine synthase activity
IRT44_05485	COG2199	diguanylate cyclase activity
IRT44_05485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRT44_05495	COG3852	Histidine kinase
IRT44_05505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IRT44_05510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IRT44_05545	COG1982	Orn Lys Arg decarboxylase major
IRT44_05550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IRT44_05555	COG3870	Protein conserved in bacteria
IRT44_05560	COG1728	Protein conserved in bacteria
IRT44_05565	COG0470	DNA polymerase III
IRT44_05570	COG1774	PSP1 C-terminal conserved region
IRT44_05575	COG4467	Involved in initiation control of chromosome replication
IRT44_05580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IRT44_05585	COG2827	Endonuclease containing a URI domain
IRT44_05590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IRT44_05595	COG2002	toxin-antitoxin pair type II binding
IRT44_05600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRT44_05600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRT44_05605	COG0084	hydrolase, TatD family'
IRT44_05615	COG3584	3D domain protein
IRT44_05615	COG3583	domain protein
IRT44_05625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IRT44_05630	COG4466	Protein conserved in bacteria
IRT44_05645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IRT44_05650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRT44_05655	COG0251	oxidation-reduction process
IRT44_05660	COG2088	sporulation resulting in formation of a cellular spore
IRT44_05670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IRT44_05675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IRT44_05680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IRT44_05685	COG0193	aminoacyl-tRNA hydrolase activity
IRT44_05695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IRT44_05700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRT44_05705	COG2002	toxin-antitoxin pair type II binding
IRT44_05710	COG2244	polysaccharide biosynthetic process
IRT44_05715	COG3956	TIGRFAM MazG family protein
IRT44_05720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IRT44_05750	COG1098	S1 RNA binding domain
IRT44_05755	COG2208	phosphoserine phosphatase activity
IRT44_05760	COG2304	oxidoreductase activity
IRT44_05765	COG0515	serine threonine protein kinase
IRT44_05775	COG3610	response to peptide
IRT44_05780	COG0037	tRNA processing
IRT44_05785	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IRT44_05790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRT44_05805	COG0561	phosphatase activity
IRT44_05810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IRT44_05820	COG0803	Belongs to the bacterial solute-binding protein 9 family
IRT44_05825	COG1121	(ABC) transporter
IRT44_05830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IRT44_05835	COG0735	belongs to the Fur family
IRT44_05840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IRT44_05850	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IRT44_05880	COG0616	signal peptide processing
IRT44_05900	COG2894	cell division
IRT44_06015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IRT44_06020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IRT44_06025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRT44_06035	COG0512	Glutamine amidotransferase of anthranilate synthase
IRT44_06045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IRT44_06050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRT44_06055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IRT44_06060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IRT44_06065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IRT44_06070	COG1396	sequence-specific DNA binding
IRT44_06075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IRT44_06080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IRT44_06115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IRT44_06130	COG3880	PFAM UvrB UvrC protein
IRT44_06135	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IRT44_06140	COG0542	response to heat
IRT44_06145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IRT44_06155	COG1183	phosphatidylcholine synthase activity
IRT44_06170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IRT44_06175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IRT44_06180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IRT44_06185	COG1045	serine acetyltransferase
IRT44_06190	COG0215	cysteine-tRNA ligase activity
IRT44_06195	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IRT44_06200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRT44_06205	COG3688	RNA-binding protein containing a PIN domain
IRT44_06215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IRT44_06225	COG0250	Participates in transcription elongation, termination and antitermination
IRT44_06230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IRT44_06235	COG0081	regulation of translation
IRT44_06240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IRT44_06245	COG0222	ribosome binding
IRT44_06250	COG2813	Specifically methylates the guanine in position
IRT44_06255	COG0085	RNA polymerase activity
IRT44_06260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IRT44_06265	COG1358	cellular component organization or biogenesis
IRT44_06270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IRT44_06275	COG0049	tRNA binding
IRT44_06280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IRT44_06285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IRT44_06300	COG0051	transcription antitermination factor activity, RNA binding
IRT44_06305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IRT44_06310	COG0088	Forms part of the polypeptide exit tunnel
IRT44_06315	COG0089	rRNA binding
IRT44_06320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IRT44_06325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IRT44_06330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IRT44_06335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IRT44_06340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IRT44_06345	COG0255	Belongs to the universal ribosomal protein uL29 family
IRT44_06350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IRT44_06355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IRT44_06360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IRT44_06365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IRT44_06370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IRT44_06375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IRT44_06380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IRT44_06385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IRT44_06390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IRT44_06395	COG1841	ribosomal large subunit assembly
IRT44_06400	COG0200	Binds to the 23S rRNA
IRT44_06405	COG0201	protein transport
IRT44_06410	COG0563	adenylate kinase activity
IRT44_06415	COG0024	Methionine aminopeptidase
IRT44_06420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IRT44_06425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IRT44_06430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IRT44_06435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IRT44_06440	COG0202	RNA polymerase activity
IRT44_06445	COG0203	ribosomal protein L17
IRT44_06450	COG1122	ATPase activity
IRT44_06455	COG1122	ATPase activity
IRT44_06460	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IRT44_06465	COG0101	tRNA pseudouridine synthase activity
IRT44_06470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IRT44_06475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IRT44_06480	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_06485	COG0489	protein tyrosine kinase activity
IRT44_06500	COG0726	polysaccharide deacetylase
IRT44_06590	COG0010	Belongs to the arginase family
IRT44_06600	COG1595	DNA-templated transcription, initiation
IRT44_06605	COG5662	AntiSigma factor
IRT44_06610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IRT44_06620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRT44_06625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IRT44_06635	COG2801	Transposase and inactivated derivatives
IRT44_06660	COG0604	alcohol dehydrogenase
IRT44_06665	COG1733	regulation of RNA biosynthetic process
IRT44_06685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_06690	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_06695	COG1120	ATPase activity
IRT44_06705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IRT44_06710	COG2814	Major facilitator Superfamily
IRT44_06755	COG0745	RESPONSE REGULATOR receiver
IRT44_06760	COG3850	Histidine kinase
IRT44_06760	COG5002	protein histidine kinase activity
IRT44_06775	COG3279	Response regulator of the LytR AlgR family
IRT44_06780	COG0427	acetyl-CoA hydrolase
IRT44_06785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRT44_06790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRT44_06800	COG2259	Doxx family
IRT44_06805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IRT44_06810	COG1846	Transcriptional regulator
IRT44_06820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_06825	COG2313	pseudouridylate synthase activity
IRT44_06830	COG2217	Heavy metal translocating P-type atpase
IRT44_06840	COG2608	mercury ion transmembrane transporter activity
IRT44_06855	COG4753	response regulator
IRT44_06855	COG2207	Transcriptional regulator
IRT44_06860	COG2972	Histidine kinase
IRT44_06870	COG2188	Transcriptional regulator
IRT44_06875	COG1263	PTS System
IRT44_06875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRT44_06880	COG0366	Alpha amylase catalytic
IRT44_06885	COG0561	phosphatase activity
IRT44_06905	COG1971	Probably functions as a manganese efflux pump
IRT44_06910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IRT44_06935	COG4585	Histidine kinase
IRT44_06940	COG2197	response regulator
IRT44_06950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IRT44_06955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRT44_06965	COG0778	Nitroreductase
IRT44_06970	COG5002	protein histidine kinase activity
IRT44_06975	COG0745	RESPONSE REGULATOR receiver
IRT44_06990	COG2610	gluconate transmembrane transporter activity
IRT44_06995	COG1929	Belongs to the glycerate kinase type-1 family
IRT44_07000	COG0840	transmembrane signaling receptor activity
IRT44_07005	COG3835	regulator
IRT44_07015	COG0475	glutathione-regulated potassium exporter activity
IRT44_07035	COG1522	sequence-specific DNA binding
IRT44_07040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRT44_07060	COG0740	serine-type endopeptidase activity
IRT44_07075	COG1404	Belongs to the peptidase S8 family
IRT44_07085	COG0583	DNA-binding transcription factor activity
IRT44_07090	COG0372	Belongs to the citrate synthase family
IRT44_07095	COG1349	DNA-binding transcription factor activity
IRT44_07100	COG1105	Belongs to the carbohydrate kinase PfkB family
IRT44_07105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_07105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRT44_07105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRT44_07110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_07125	COG1902	pentaerythritol trinitrate reductase activity
IRT44_07135	COG5583	Uncharacterized small protein (DUF2292)
IRT44_07160	COG0714	Associated with various cellular activities
IRT44_07175	COG0425	Belongs to the sulfur carrier protein TusA family
IRT44_07175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRT44_07180	COG1999	signal sequence binding
IRT44_07190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IRT44_07200	COG0667	Aldo Keto reductase
IRT44_07210	COG1316	TRANSCRIPTIONal
IRT44_07230	COG4166	transmembrane transport
IRT44_07245	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_07255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IRT44_07260	COG0573	inorganic phosphate transmembrane transporter activity
IRT44_07265	COG0581	inorganic phosphate transmembrane transporter activity
IRT44_07270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRT44_07275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRT44_07280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IRT44_07300	COG0640	Transcriptional regulator
IRT44_07315	COG0736	holo-[acyl-carrier-protein] synthase activity
IRT44_07320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IRT44_07330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IRT44_07335	COG0864	Transcriptional regulator
IRT44_07340	COG2337	Toxic component of a toxin-antitoxin (TA) module
IRT44_07345	COG2172	sigma factor antagonist activity
IRT44_07350	COG2208	phosphoserine phosphatase activity
IRT44_07360	COG2172	sigma factor antagonist activity
IRT44_07365	COG1191	sigma factor activity
IRT44_07370	COG2183	response to ionizing radiation
IRT44_07385	COG3091	SprT-like family
IRT44_07390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IRT44_07395	COG0802	atpase or kinase
IRT44_07400	COG1214	PFAM Peptidase M22, glycoprotease
IRT44_07405	COG0456	acetyltransferase
IRT44_07410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IRT44_07420	COG0488	(ABC) transporter
IRT44_07425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IRT44_07430	COG0315	cyclic pyranopterin monophosphate synthase activity
IRT44_07430	COG0521	Mo-molybdopterin cofactor biosynthetic process
IRT44_07445	COG0805	protein transport
IRT44_07455	COG2801	Transposase and inactivated derivatives
IRT44_07465	COG2340	Cysteine-rich secretory protein family
IRT44_07470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IRT44_07480	COG2182	Extracellular solute-binding protein
IRT44_07485	COG1175	transmembrane transport
IRT44_07490	COG0395	ABC-type sugar transport system, permease component
IRT44_07625	COG0714	Associated with various cellular activities
IRT44_07635	COG1305	Transglutaminase-like
IRT44_07640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IRT44_07640	COG0519	Catalyzes the synthesis of GMP from XMP
IRT44_07645	COG2252	PERMEase
IRT44_07650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IRT44_07655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IRT44_07660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IRT44_07670	COG2801	Transposase and inactivated derivatives
IRT44_07705	COG1136	(ABC) transporter
IRT44_07720	COG0745	RESPONSE REGULATOR receiver
IRT44_07725	COG2205	protein histidine kinase activity
IRT44_07730	COG1136	(ABC) transporter
IRT44_07735	COG0577	efflux transmembrane transporter activity
IRT44_07745	COG0747	negative chemotaxis
IRT44_07755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_07760	COG0444	Belongs to the ABC transporter superfamily
IRT44_07765	COG4608	Belongs to the ABC transporter superfamily
IRT44_07770	COG2059	Chromate
IRT44_07775	COG2059	Chromate
IRT44_07780	COG0405	Gamma-glutamyltransferase
IRT44_07785	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IRT44_07805	COG1459	type II secretion system
IRT44_07820	COG2304	oxidoreductase activity
IRT44_07825	COG2304	oxidoreductase activity
IRT44_07830	COG2304	oxidoreductase activity
IRT44_07855	COG2304	oxidoreductase activity
IRT44_07870	COG2304	oxidoreductase activity
IRT44_07885	COG1979	alcohol dehydrogenase
IRT44_07895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IRT44_07900	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRT44_07905	COG0047	phosphoribosylformylglycinamidine synthase activity
IRT44_07910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRT44_07915	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IRT44_07920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IRT44_07925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IRT44_07960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IRT44_07965	COG0559	Belongs to the binding-protein-dependent transport system permease family
IRT44_08000	COG2814	Major facilitator Superfamily
IRT44_08005	COG0789	Transcriptional regulator
IRT44_08010	COG1414	Transcriptional regulator
IRT44_08020	COG3842	ATPase activity
IRT44_08025	COG1176	ABC-type spermidine putrescine transport system, permease component I
IRT44_08030	COG1177	transmembrane transport
IRT44_08035	COG2195	Cleaves the N-terminal amino acid of tripeptides
IRT44_08040	COG0683	leucine binding
IRT44_08045	COG2205	protein histidine kinase activity
IRT44_08045	COG2770	Histidine kinase
IRT44_08050	COG0745	RESPONSE REGULATOR receiver
IRT44_08055	COG1470	cell adhesion involved in biofilm formation
IRT44_08060	COG4496	protein, YerC YecD
IRT44_08065	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IRT44_08075	COG0584	glycerophosphoryl diester phosphodiesterase
IRT44_08085	COG0210	DNA helicase
IRT44_08090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IRT44_08105	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_08115	COG0688	phosphatidylethanolamine metabolic process
IRT44_08120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IRT44_08125	COG0154	amidase activity
IRT44_08130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IRT44_08145	COG4555	ABC transporter
IRT44_08150	COG1668	transmembrane transport
IRT44_08155	COG1940	carbohydrate kinase activity
IRT44_08160	COG1597	lipid kinase activity
IRT44_08165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IRT44_08175	COG3328	transposase activity
IRT44_08205	COG0827	DNA restriction-modification system
IRT44_08210	COG0827	DNA restriction-modification system
IRT44_08215	COG1024	Enoyl-CoA hydratase
IRT44_08220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRT44_08230	COG1609	Transcriptional regulator
IRT44_08235	COG3246	L-lysine catabolic process to acetate
IRT44_08240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IRT44_08245	COG2610	gluconate transmembrane transporter activity
IRT44_08250	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_08255	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
IRT44_08265	COG5646	InterPro IPR014922
IRT44_08275	COG2207	Transcriptional regulator
IRT44_08285	COG0559	Belongs to the binding-protein-dependent transport system permease family
IRT44_08305	COG0010	Belongs to the arginase family
IRT44_08310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IRT44_08315	COG1228	amidohydrolase
IRT44_08320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_08320	COG2207	Transcriptional regulator
IRT44_08325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_08330	COG2819	hydrolase of the alpha beta superfamily
IRT44_08335	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_08340	COG1169	isochorismate synthase
IRT44_08345	COG1021	2,3-dihydroxybenzoate-AMP ligase
IRT44_08350	COG3433	isochorismatase activity
IRT44_08350	COG1535	isochorismatase
IRT44_08355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IRT44_08360	COG3251	PFAM MbtH domain protein
IRT44_08385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IRT44_08395	COG3773	Cell wall hydrolase
IRT44_08420	COG0501	Belongs to the peptidase M48B family
IRT44_08425	COG2259	Doxx family
IRT44_08430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_08440	COG1823	symporter activity
IRT44_08445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IRT44_08450	COG0583	DNA-binding transcription factor activity
IRT44_08455	COG1380	Effector of murein hydrolase LrgA
IRT44_08460	COG1346	cytolysis
IRT44_08475	COG0071	Belongs to the small heat shock protein (HSP20) family
IRT44_08490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRT44_08495	COG1360	Flagellar Motor Protein
IRT44_08500	COG1733	regulation of RNA biosynthetic process
IRT44_08505	COG0693	protein deglycase activity
IRT44_08540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IRT44_08545	COG3852	Histidine kinase
IRT44_08550	COG2204	response regulator
IRT44_08555	COG2031	fatty acid transporter
IRT44_08560	COG1253	flavin adenine dinucleotide binding
IRT44_08600	COG0577	efflux transmembrane transporter activity
IRT44_08605	COG1136	(ABC) transporter
IRT44_08610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_08620	COG0166	Belongs to the GPI family
IRT44_08625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IRT44_08645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IRT44_08655	COG1199	ATP-dependent helicase activity
IRT44_08655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IRT44_08665	COG0004	ammonium transporteR
IRT44_08680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IRT44_08695	COG2996	Protein conserved in bacteria
IRT44_08715	COG2358	TRAP transporter, solute receptor (TAXI family
IRT44_08720	COG4191	Histidine kinase
IRT44_08725	COG0784	Response regulator, receiver
IRT44_08755	COG2133	pyrroloquinoline quinone binding
IRT44_08770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IRT44_08775	COG1114	Component of the transport system for branched-chain amino acids
IRT44_08780	COG0697	spore germination
IRT44_08785	COG0824	Thioesterase
IRT44_08795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRT44_08810	COG0745	RESPONSE REGULATOR receiver
IRT44_08815	COG2205	protein histidine kinase activity
IRT44_08820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_08835	COG1649	PFAM Uncharacterised BCR, COG1649
IRT44_08840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IRT44_08845	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IRT44_08855	COG0346	lactoylglutathione lyase activity
IRT44_08875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IRT44_08885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IRT44_08905	COG1268	BioY protein
IRT44_08915	COG5002	protein histidine kinase activity
IRT44_08920	COG0745	RESPONSE REGULATOR receiver
IRT44_08925	COG0791	NLP P60 protein
IRT44_08935	COG1842	Phage shock protein A
IRT44_08940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IRT44_08945	COG4758	membrane
IRT44_08950	COG4585	Histidine kinase
IRT44_08955	COG2197	response regulator
IRT44_08965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IRT44_08990	COG3384	dioxygenase
IRT44_08995	COG1988	membrane-bound metal-dependent
IRT44_09025	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_09030	COG0456	acetyltransferase
IRT44_09035	COG3557	Belongs to the UPF0374 family
IRT44_09040	COG1132	(ABC) transporter
IRT44_09045	COG2814	Major facilitator Superfamily
IRT44_09050	COG2084	Dehydrogenase
IRT44_09055	COG2738	Putative neutral zinc metallopeptidase
IRT44_09060	COG0067	glutamate synthase
IRT44_09060	COG0070	glutamate synthase
IRT44_09060	COG0069	glutamate synthase activity
IRT44_09070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IRT44_09075	COG4555	ABC transporter
IRT44_09110	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IRT44_09115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IRT44_09120	COG0546	phosphoglycolate phosphatase activity
IRT44_09130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IRT44_09135	COG1363	Peptidase, m42
IRT44_09145	COG2096	Adenosyltransferase
IRT44_09155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_09160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IRT44_09165	COG0735	belongs to the Fur family
IRT44_09170	COG3858	chitin binding
IRT44_09275	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IRT44_09280	COG3189	MarR family transcriptional regulator
IRT44_09285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IRT44_09295	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IRT44_09300	COG1140	nitrate reductase beta subunit
IRT44_09305	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IRT44_09310	COG2181	nitrate reductase activity
IRT44_09315	COG2223	nitrite transmembrane transporter activity
IRT44_09325	COG0535	radical SAM domain protein
IRT44_09335	COG0303	'Molybdopterin
IRT44_09340	COG2233	PERMEase
IRT44_09345	COG3382	B3 4 domain protein
IRT44_09350	COG0328	RNA-DNA hybrid ribonuclease activity
IRT44_09360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IRT44_09375	COG0546	phosphoglycolate phosphatase activity
IRT44_09380	COG2766	serine protein kinase
IRT44_09385	COG2718	Belongs to the UPF0229 family
IRT44_09395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IRT44_09400	COG0438	transferase activity, transferring glycosyl groups
IRT44_09415	COG1482	cell wall glycoprotein biosynthetic process
IRT44_09425	COG3279	Response regulator of the LytR AlgR family
IRT44_09435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_09475	COG1522	sequence-specific DNA binding
IRT44_09480	COG0436	Aminotransferase
IRT44_09485	COG0833	amino acid
IRT44_09490	COG1840	ABC-type Fe3 transport system, periplasmic component
IRT44_09495	COG3842	ATPase activity
IRT44_09505	COG0647	UMP catabolic process
IRT44_09510	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IRT44_09515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IRT44_09565	COG2721	sulfolactate sulfo-lyase activity
IRT44_09570	COG2721	sulfolactate sulfo-lyase activity
IRT44_09635	COG0783	Belongs to the Dps family
IRT44_09640	COG0746	molybdenum cofactor guanylyltransferase activity
IRT44_09645	COG3344	reverse transcriptase
IRT44_09650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IRT44_09655	COG2223	nitrite transmembrane transporter activity
IRT44_09660	COG5609	conserved protein (DUF2294)
IRT44_09665	COG0303	'Molybdopterin
IRT44_09670	COG1763	Mo-molybdopterin cofactor biosynthetic process
IRT44_09680	COG1968	undecaprenyl-diphosphatase activity
IRT44_09685	COG2259	Doxx family
IRT44_09700	COG2363	Small membrane protein
IRT44_09710	COG2719	SpoVR family
IRT44_09725	COG2807	transmembrane transport
IRT44_09730	COG0583	DNA-binding transcription factor activity
IRT44_09745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRT44_09750	COG1845	cytochrome c oxidase, subunit III
IRT44_09760	COG0492	ferredoxin-NADP+ reductase activity
IRT44_09765	COG2814	Major facilitator Superfamily
IRT44_09775	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IRT44_09780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRT44_09790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IRT44_09800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IRT44_09825	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IRT44_09855	COG1492	cobalamin metabolic process
IRT44_09860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IRT44_09870	COG1648	precorrin-2 dehydrogenase activity
IRT44_09870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRT44_09875	COG2204	response regulator
IRT44_09920	COG1802	Transcriptional regulator
IRT44_09925	COG0045	succinate-CoA ligase (ADP-forming) activity
IRT44_09940	COG2009	succinate dehydrogenase
IRT44_09945	COG1053	succinate dehydrogenase
IRT44_09950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IRT44_09970	COG2076	Multidrug Resistance protein
IRT44_09975	COG2076	Multidrug Resistance protein
IRT44_09980	COG0095	Lipoate-protein ligase
IRT44_09985	COG1301	dicarboxylic acid transport
IRT44_09990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IRT44_09995	COG3832	glyoxalase III activity
IRT44_10000	COG0640	Transcriptional regulator
IRT44_10005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IRT44_10010	COG3290	protein histidine kinase activity
IRT44_10015	COG4565	transcriptional regulatory protein
IRT44_10020	COG1619	proteins homologs of microcin C7 resistance protein MccF
IRT44_10025	COG0783	Belongs to the Dps family
IRT44_10030	COG1072	(Pantothenic acid kinase))
IRT44_10035	COG1683	Conserved Protein
IRT44_10040	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IRT44_10045	COG1737	Transcriptional regulator
IRT44_10050	COG1070	Carbohydrate kinase
IRT44_10060	COG0583	DNA-binding transcription factor activity
IRT44_10090	COG0180	Tryptophanyl-tRNA synthetase
IRT44_10110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_10115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRT44_10130	COG0402	S-adenosylhomocysteine deaminase activity
IRT44_10135	COG3328	transposase activity
IRT44_10150	COG1737	Transcriptional regulator
IRT44_10155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRT44_10160	COG1653	transport
IRT44_10165	COG1175	transmembrane transport
IRT44_10170	COG0395	ABC-type sugar transport system, permease component
IRT44_10175	COG2971	BadF BadG BcrA BcrD
IRT44_10190	COG3706	GGDEF domain
IRT44_10195	COG1757	Na H antiporter
IRT44_10220	COG1175	transmembrane transport
IRT44_10225	COG0395	ABC-type sugar transport system, permease component
IRT44_10230	COG0673	inositol 2-dehydrogenase activity
IRT44_10260	COG0492	ferredoxin-NADP+ reductase activity
IRT44_10270	COG0450	alkyl hydroperoxide reductase
IRT44_10290	COG0189	ligase activity
IRT44_10295	COG0189	ligase activity
IRT44_10300	COG0189	ligase activity
IRT44_10305	COG4399	Belongs to the UPF0754 family
IRT44_10310	COG4109	DRTGG domain
IRT44_10315	COG0640	Transcriptional regulator
IRT44_10325	COG0587	DNA-directed DNA polymerase activity
IRT44_10330	COG0281	malic enzyme
IRT44_10335	COG2186	Transcriptional regulator
IRT44_10345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IRT44_10350	COG0825	malonyl-CoA metabolic process
IRT44_10355	COG0205	6-phosphofructokinase activity
IRT44_10365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRT44_10370	COG0824	Thioesterase
IRT44_10375	COG3030	protein affecting phage T7 exclusion by the F plasmid
IRT44_10380	COG0628	permease
IRT44_10390	COG0538	isocitrate dehydrogenase activity
IRT44_10395	COG0039	L-malate dehydrogenase activity
IRT44_10400	COG0745	RESPONSE REGULATOR receiver
IRT44_10405	COG5002	protein histidine kinase activity
IRT44_10410	COG0704	Plays a role in the regulation of phosphate uptake
IRT44_10420	COG2720	vancomycin resistance protein
IRT44_10425	COG1846	Transcriptional regulator
IRT44_10430	COG1566	PFAM secretion protein HlyD family protein
IRT44_10440	COG2814	Major facilitator Superfamily
IRT44_10460	COG2861	carbohydrate metabolic process
IRT44_10465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRT44_10465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRT44_10470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IRT44_10475	COG0237	dephospho-CoA kinase activity
IRT44_10480	COG0739	heme binding
IRT44_10480	COG1196	nuclear chromosome segregation
IRT44_10480	COG0741	lytic transglycosylase activity
IRT44_10485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IRT44_10500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IRT44_10510	COG1484	DNA-dependent DNA replication
IRT44_10560	COG3973	AAA domain
IRT44_10570	COG0778	Nitroreductase
IRT44_10580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IRT44_10585	COG0747	negative chemotaxis
IRT44_10590	COG0601	transmembrane transport
IRT44_10595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_10600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRT44_10605	COG0444	Belongs to the ABC transporter superfamily
IRT44_10610	COG4608	Belongs to the ABC transporter superfamily
IRT44_10625	COG0247	lactate metabolic process
IRT44_10650	COG3773	Cell wall hydrolase
IRT44_10670	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IRT44_10680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IRT44_10685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IRT44_10690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IRT44_10695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IRT44_10700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IRT44_10705	COG0175	sulfate reduction
IRT44_10710	COG2046	Belongs to the sulfate adenylyltransferase family
IRT44_10715	COG0028	Belongs to the TPP enzyme family
IRT44_10720	COG0440	acetolactate synthase activity
IRT44_10725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IRT44_10730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_10750	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_10755	COG0521	Mo-molybdopterin cofactor biosynthetic process
IRT44_10760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRT44_10765	COG0586	Pfam SNARE associated Golgi protein
IRT44_10770	COG3326	Membrane
IRT44_10780	COG0569	domain protein
IRT44_10785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRT44_10790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IRT44_10800	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IRT44_10805	COG1606	tRNA processing
IRT44_10810	COG1691	(AIR) carboxylase
IRT44_10820	COG1193	negative regulation of DNA recombination
IRT44_10825	COG3766	membrane
IRT44_10835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IRT44_10840	COG2851	Citrate transporter
IRT44_10845	COG3290	protein histidine kinase activity
IRT44_10850	COG4565	transcriptional regulatory protein
IRT44_10860	COG2362	D-Aminopeptidase
IRT44_10865	COG0438	transferase activity, transferring glycosyl groups
IRT44_10890	COG0728	peptidoglycan biosynthetic process
IRT44_10900	COG2244	polysaccharide biosynthetic process
IRT44_10905	COG2226	methyltransferase
IRT44_10915	COG2264	protein methyltransferase activity
IRT44_10920	COG0183	Belongs to the thiolase family
IRT44_10925	COG1316	TRANSCRIPTIONal
IRT44_10930	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_10935	COG1309	transcriptional regulator
IRT44_10940	COG1024	Enoyl-CoA hydratase
IRT44_10945	COG2086	electron transfer activity
IRT44_10950	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IRT44_10960	COG3118	belongs to the thioredoxin family
IRT44_10965	COG0322	excinuclease ABC activity
IRT44_10970	COG1794	racemase activity, acting on amino acids and derivatives
IRT44_10985	COG2009	succinate dehydrogenase
IRT44_10990	COG1053	succinate dehydrogenase
IRT44_10995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IRT44_11000	COG0477	Major facilitator Superfamily
IRT44_11005	COG1846	Transcriptional regulator
IRT44_11020	COG1406	Chemotaxis phosphatase CheX
IRT44_11030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_11035	COG2197	response regulator
IRT44_11040	COG3290	protein histidine kinase activity
IRT44_11040	COG3829	transcription factor binding
IRT44_11045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IRT44_11050	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_11055	COG1113	amino acid transport
IRT44_11070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRT44_11075	COG3711	transcriptional antiterminator
IRT44_11075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_11080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRT44_11120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_11125	COG1115	amino acid carrier protein
IRT44_11135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IRT44_11140	COG0644	oxidoreductase
IRT44_11170	COG1216	Glycosyl transferase, family 2
IRT44_11185	COG0463	Glycosyl transferase, family 2
IRT44_11195	COG0662	Cupin 2, conserved barrel domain protein
IRT44_11195	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IRT44_11200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_11210	COG1216	Glycosyl transferase, family 2
IRT44_11225	COG1216	Glycosyl transferase, family 2
IRT44_11260	COG4166	transmembrane transport
IRT44_11265	COG3290	protein histidine kinase activity
IRT44_11265	COG3829	transcription factor binding
IRT44_11270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_11275	COG0601	transmembrane transport
IRT44_11280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_11285	COG0444	Belongs to the ABC transporter superfamily
IRT44_11295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IRT44_11300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IRT44_11305	COG5401	PFAM Sporulation and spore germination
IRT44_11315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IRT44_11325	COG0622	Phosphoesterase
IRT44_11330	COG0544	peptidyl-prolyl cis-trans isomerase activity
IRT44_11335	COG0740	serine-type endopeptidase activity
IRT44_11340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IRT44_11345	COG0470	DNA polymerase III
IRT44_11345	COG1067	ATP-dependent peptidase activity
IRT44_11355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IRT44_11370	COG0840	transmembrane signaling receptor activity
IRT44_11375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IRT44_11380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IRT44_11385	COG0181	hydroxymethylbilane synthase activity
IRT44_11395	COG0113	porphobilinogen synthase activity
IRT44_11400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IRT44_11405	COG2801	Transposase and inactivated derivatives
IRT44_11430	COG0737	Belongs to the 5'-nucleotidase family
IRT44_11450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IRT44_11455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IRT44_11460	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IRT44_11465	COG1388	LysM domain
IRT44_11485	COG2208	phosphoserine phosphatase activity
IRT44_11500	COG0525	valine-tRNA ligase activity
IRT44_11505	COG0285	dihydrofolate synthase activity
IRT44_11510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IRT44_11515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRT44_11520	COG0475	glutathione-regulated potassium exporter activity
IRT44_11525	COG0490	domain, Protein
IRT44_11550	COG0424	maF-like protein
IRT44_11555	COG2003	Belongs to the UPF0758 family
IRT44_11560	COG1077	Cell shape determining protein MreB Mrl
IRT44_11565	COG1792	Involved in formation and maintenance of cell shape
IRT44_11570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IRT44_11575	COG0768	penicillin binding
IRT44_11580	COG0850	regulation of cytokinetic process
IRT44_11585	COG2894	cell division
IRT44_11590	COG0772	Belongs to the SEDS family
IRT44_11605	COG1994	Peptidase M50
IRT44_11610	COG1530	ribonuclease E activity
IRT44_11615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IRT44_11620	COG2868	ribosomal protein
IRT44_11625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IRT44_11635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IRT44_11650	COG4492	Belongs to the UPF0735 family
IRT44_11655	COG0460	homoserine dehydrogenase
IRT44_11660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IRT44_11665	COG0083	homoserine kinase activity
IRT44_11670	COG0077	Prephenate dehydratase
IRT44_11675	COG1388	LysM domain
IRT44_11705	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IRT44_11710	COG0632	four-way junction helicase activity
IRT44_11715	COG2255	four-way junction helicase activity
IRT44_11730	COG2385	sporulation resulting in formation of a cellular spore
IRT44_11735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IRT44_11740	COG0343	queuine tRNA-ribosyltransferase activity
IRT44_11745	COG1862	Preprotein translocase
IRT44_11755	COG0598	Magnesium transport protein CorA
IRT44_11760	COG2323	membrane
IRT44_11765	COG2244	polysaccharide biosynthetic process
IRT44_11775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRT44_11775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRT44_11780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRT44_11780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRT44_11785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IRT44_11790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IRT44_11790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IRT44_11795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRT44_11800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IRT44_11805	COG1490	D-aminoacyl-tRNA deacylase activity
IRT44_11815	COG2267	carboxylic ester hydrolase activity
IRT44_11825	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_11825	COG3103	Sh3 type 3 domain protein
IRT44_11825	COG4991	sh3 domain protein
IRT44_11835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IRT44_11840	COG0124	histidyl-tRNA synthetase
IRT44_11845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IRT44_11855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IRT44_11865	COG1349	DNA-binding transcription factor activity
IRT44_11870	COG0673	inositol 2-dehydrogenase activity
IRT44_11885	COG1959	2 iron, 2 sulfur cluster binding
IRT44_11890	COG1104	cysteine desulfurase activity
IRT44_11915	COG0861	Integral membrane protein TerC family
IRT44_11920	COG0628	permease
IRT44_11925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IRT44_11930	COG4472	Bacterial protein of unknown function (DUF965)
IRT44_11935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IRT44_11940	COG3906	Belongs to the UPF0473 family
IRT44_11945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IRT44_11950	COG4122	O-methyltransferase activity
IRT44_11955	COG0572	uridine kinase
IRT44_11960	COG3344	reverse transcriptase
IRT44_11965	COG0768	penicillin binding
IRT44_11980	COG1349	DNA-binding transcription factor activity
IRT44_11985	COG1069	ribulokinase activity
IRT44_11990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_12000	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRT44_12005	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRT44_12025	COG2801	Transposase and inactivated derivatives
IRT44_12040	COG1414	Transcriptional regulator
IRT44_12045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRT44_12055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRT44_12065	COG1131	(ABC) transporter
IRT44_12075	COG1131	(ABC) transporter
IRT44_12080	COG1725	Transcriptional regulator
IRT44_12100	COG1611	Belongs to the LOG family
IRT44_12125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_12130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IRT44_12135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IRT44_12140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IRT44_12155	COG0010	Belongs to the arginase family
IRT44_12165	COG0488	(ABC) transporter
IRT44_12170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRT44_12175	COG3191	aminopeptidase activity
IRT44_12185	COG1413	lyase activity
IRT44_12190	COG1233	COG1233 Phytoene dehydrogenase and related
IRT44_12200	COG4166	transmembrane transport
IRT44_12205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IRT44_12210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IRT44_12215	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IRT44_12220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IRT44_12225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IRT44_12230	COG1534	Rna-binding protein
IRT44_12235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IRT44_12240	COG1713	HD superfamily hydrolase involved in NAD metabolism
IRT44_12245	COG0799	negative regulation of ribosome biogenesis
IRT44_12250	COG2226	methyltransferase
IRT44_12255	COG0495	leucyl-tRNA aminoacylation
IRT44_12260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRT44_12265	COG1596	polysaccharide export
IRT44_12265	COG1555	photosystem II stabilization
IRT44_12270	COG0367	asparagine synthase
IRT44_12275	COG2131	deaminase
IRT44_12280	COG0658	competence protein
IRT44_12280	COG2333	competence protein COMEC
IRT44_12285	COG1595	DNA-templated transcription, initiation
IRT44_12300	COG0268	Binds directly to 16S ribosomal RNA
IRT44_12310	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_12325	COG0444	Belongs to the ABC transporter superfamily
IRT44_12330	COG4608	Belongs to the ABC transporter superfamily
IRT44_12335	COG0747	negative chemotaxis
IRT44_12340	COG0601	transmembrane transport
IRT44_12345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_12350	COG0006	proline dipeptidase activity
IRT44_12370	COG0481	GTPase activity
IRT44_12375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IRT44_12380	COG1420	regulation of RNA biosynthetic process
IRT44_12390	COG0443	Heat shock 70 kDa protein
IRT44_12400	COG2264	protein methyltransferase activity
IRT44_12405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IRT44_12410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRT44_12420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IRT44_12425	COG1380	Effector of murein hydrolase LrgA
IRT44_12430	COG1346	cytolysis
IRT44_12435	COG1283	sodium-dependent phosphate transmembrane transporter activity
IRT44_12455	COG1181	Belongs to the D-alanine--D-alanine ligase family
IRT44_12460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IRT44_12465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IRT44_12470	COG1610	YqeY-like protein
IRT44_12475	COG1030	water channel activity
IRT44_12480	COG4864	UPF0365 protein
IRT44_12505	COG1702	phosphate starvation-inducible protein PhoH
IRT44_12510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IRT44_12520	COG0295	cytidine deaminase activity
IRT44_12525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IRT44_12535	COG1381	Involved in DNA repair and RecF pathway recombination
IRT44_12545	COG0751	glycine-tRNA ligase activity
IRT44_12550	COG0517	IMP dehydrogenase activity
IRT44_12555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IRT44_12560	COG0358	DNA primase activity
IRT44_12565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IRT44_12580	COG1960	acyl-CoA dehydrogenase activity
IRT44_12585	COG2384	SAM-dependent methyltransferase
IRT44_12590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IRT44_12600	COG0793	Belongs to the peptidase S41A family
IRT44_12600	COG3409	Peptidoglycan-binding domain 1 protein
IRT44_12610	COG2801	Transposase and inactivated derivatives
IRT44_12620	COG3568	Endonuclease Exonuclease Phosphatase
IRT44_12685	COG1242	4 iron, 4 sulfur cluster binding
IRT44_12700	COG0456	acetyltransferase
IRT44_12710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IRT44_12715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IRT44_12720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IRT44_12725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_12730	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_12775	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_12785	COG3876	Protein conserved in bacteria
IRT44_12795	COG1309	transcriptional regulator
IRT44_12815	COG2249	NAD(P)H dehydrogenase (quinone) activity
IRT44_12825	COG0561	phosphatase activity
IRT44_12830	COG3842	ATPase activity
IRT44_12840	COG1408	metallophosphoesterase
IRT44_12845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IRT44_12855	COG2072	flavoprotein involved in K transport
IRT44_12865	COG2197	response regulator
IRT44_12870	COG3850	Histidine kinase
IRT44_12875	COG0351	phosphomethylpyrimidine kinase
IRT44_12885	COG1595	DNA-templated transcription, initiation
IRT44_12895	COG1428	Deoxynucleoside kinase
IRT44_12900	COG1428	Deoxynucleoside kinase
IRT44_12910	COG2154	pterin-4-alpha-carbinolamine dehydratase
IRT44_12920	COG1607	acyl-coa hydrolase
IRT44_12925	COG3011	Protein conserved in bacteria
IRT44_12945	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_12955	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_12995	COG1119	ATPase activity
IRT44_13015	COG1368	sulfuric ester hydrolase activity
IRT44_13030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRT44_13050	COG0535	radical SAM domain protein
IRT44_13060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IRT44_13065	COG0316	Belongs to the HesB IscA family
IRT44_13080	COG0367	asparagine synthase
IRT44_13085	COG3275	phosphorelay sensor kinase activity
IRT44_13090	COG3279	Response regulator of the LytR AlgR family
IRT44_13095	COG3162	membrane
IRT44_13100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_13105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_13110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IRT44_13120	COG0018	arginyl-trna synthetase
IRT44_13135	COG1410	methionine synthase
IRT44_13135	COG0646	methionine synthase
IRT44_13140	COG0646	methionine synthase
IRT44_13140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IRT44_13145	COG3663	DNA glycosylase
IRT44_13150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IRT44_13155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IRT44_13200	COG0612	Peptidase, M16
IRT44_13225	COG3279	Response regulator of the LytR AlgR family
IRT44_13265	COG3739	integral membrane protein
IRT44_13270	COG3655	Transcriptional regulator
IRT44_13290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRT44_13295	COG1116	anion transmembrane transporter activity
IRT44_13300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRT44_13305	COG1234	tRNA 3'-trailer cleavage
IRT44_13325	COG1404	Belongs to the peptidase S8 family
IRT44_13335	COG1671	Belongs to the UPF0178 family
IRT44_13340	COG0583	DNA-binding transcription factor activity
IRT44_13350	COG0833	amino acid
IRT44_13355	COG3829	transcription factor binding
IRT44_13360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRT44_13370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRT44_13380	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IRT44_13385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IRT44_13390	COG4838	Belongs to the UPF0358 family
IRT44_13395	COG0733	neurotransmitter:sodium symporter activity
IRT44_13405	COG0346	lactoylglutathione lyase activity
IRT44_13410	COG0387	Pfam Sodium calcium exchanger
IRT44_13425	COG0028	Belongs to the TPP enzyme family
IRT44_13435	COG0772	Belongs to the SEDS family
IRT44_13450	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IRT44_13455	COG2226	methyltransferase
IRT44_13460	COG1525	nuclease
IRT44_13480	COG3679	Belongs to the UPF0342 family
IRT44_13490	COG4471	UPF0298 protein
IRT44_13495	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IRT44_13505	COG4149	molybdate abc transporter
IRT44_13510	COG0725	ABC transporter, periplasmic molybdate-binding protein
IRT44_13515	COG1910	domain protein
IRT44_13525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IRT44_13550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IRT44_13560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IRT44_13565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IRT44_13570	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IRT44_13575	COG0095	Lipoate-protein ligase
IRT44_13580	COG1846	Transcriptional regulator
IRT44_13585	COG2814	Major facilitator Superfamily
IRT44_13600	COG5002	protein histidine kinase activity
IRT44_13610	COG0431	NADPH-dependent FMN reductase
IRT44_13615	COG1321	iron dependent repressor
IRT44_13620	COG1752	Esterase of the alpha-beta hydrolase superfamily
IRT44_13630	COG3872	metal-dependent enzyme
IRT44_13640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IRT44_13645	COG0006	proline dipeptidase activity
IRT44_13650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IRT44_13655	COG2707	UPF0756 membrane protein
IRT44_13660	COG2045	Belongs to the ComB family
IRT44_13665	COG1809	phosphosulfolactate synthase activity
IRT44_13680	COG3854	ATPases associated with a variety of cellular activities
IRT44_13720	COG0511	ligase activity, forming carbon-carbon bonds
IRT44_13725	COG0439	Biotin carboxylase
IRT44_13730	COG1302	Protein conserved in bacteria
IRT44_13745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRT44_13755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IRT44_13760	COG1570	exodeoxyribonuclease VII activity
IRT44_13775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IRT44_13780	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IRT44_13785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IRT44_13790	COG1438	arginine binding
IRT44_13795	COG0497	DNA recombination
IRT44_13800	COG0750	zinc metalloprotease
IRT44_13810	COG2172	sigma factor antagonist activity
IRT44_13815	COG4191	Histidine kinase
IRT44_13820	COG0288	reversible hydration of carbon dioxide
IRT44_13825	COG1408	metallophosphoesterase
IRT44_13830	COG0583	DNA-binding transcription factor activity
IRT44_13840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IRT44_13860	COG0463	Glycosyl transferase, family 2
IRT44_13875	COG3290	protein histidine kinase activity
IRT44_13875	COG3829	transcription factor binding
IRT44_13880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRT44_13885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRT44_13890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IRT44_13895	COG0022	dehydrogenase e1 component
IRT44_13900	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRT44_13910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRT44_13910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRT44_13915	COG0346	lactoylglutathione lyase activity
IRT44_13920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IRT44_13925	COG2195	Cleaves the N-terminal amino acid of tripeptides
IRT44_13945	COG1300	Membrane
IRT44_13950	COG0735	belongs to the Fur family
IRT44_13955	COG0686	Belongs to the AlaDH PNT family
IRT44_13965	COG4974	Belongs to the 'phage' integrase family
IRT44_13970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IRT44_13980	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IRT44_13990	COG4166	transmembrane transport
IRT44_13995	COG0601	transmembrane transport
IRT44_14000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_14005	COG0444	Belongs to the ABC transporter superfamily
IRT44_14010	COG4608	Belongs to the ABC transporter superfamily
IRT44_14015	COG0840	transmembrane signaling receptor activity
IRT44_14020	COG1686	Belongs to the peptidase S11 family
IRT44_14030	COG2172	sigma factor antagonist activity
IRT44_14055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRT44_14070	COG0697	spore germination
IRT44_14075	COG0019	diaminopimelate decarboxylase activity
IRT44_14080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IRT44_14085	COG1994	Peptidase M50
IRT44_14090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IRT44_14095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IRT44_14100	COG1686	Belongs to the peptidase S11 family
IRT44_14105	COG2715	membrane protein required for spore maturation
IRT44_14110	COG0700	Nucleoside recognition
IRT44_14115	COG1187	pseudouridine synthase activity
IRT44_14120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_14125	COG1333	cytochrome c biogenesis protein
IRT44_14130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IRT44_14135	COG0745	RESPONSE REGULATOR receiver
IRT44_14140	COG5002	protein histidine kinase activity
IRT44_14145	COG0546	phosphoglycolate phosphatase activity
IRT44_14155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IRT44_14180	COG4955	Helix-turn-helix domain
IRT44_14185	COG0514	ATP-dependent DNA helicase (RecQ)
IRT44_14210	COG4862	establishment of competence for transformation
IRT44_14215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRT44_14220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRT44_14225	COG0252	asparaginase activity
IRT44_14230	COG2339	peptidase activity
IRT44_14250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IRT44_14255	COG2937	Belongs to the GPAT DAPAT family
IRT44_14260	COG0539	negative regulation of cytoplasmic translation
IRT44_14265	COG1304	FMN binding
IRT44_14285	COG1160	GTP binding
IRT44_14290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IRT44_14295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IRT44_14330	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IRT44_14340	COG0302	gtp cyclohydrolase
IRT44_14355	COG0741	lytic transglycosylase activity
IRT44_14370	COG0142	geranyltranstransferase activity
IRT44_14380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IRT44_14385	COG0163	prenyltransferase activity
IRT44_14400	COG0105	UTP biosynthetic process
IRT44_14405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IRT44_14415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IRT44_14420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IRT44_14425	COG4401	Chorismate mutase type I
IRT44_14435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IRT44_14440	COG0134	indole-3-glycerol-phosphate synthase activity
IRT44_14445	COG0135	phosphoribosylanthranilate isomerase activity
IRT44_14455	COG0159	tryptophan synthase activity
IRT44_14460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRT44_14470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IRT44_14475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRT44_14535	COG0069	glutamate synthase activity
IRT44_14540	COG3361	conserved protein (COG2071)
IRT44_14545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_14550	COG1694	Mazg nucleotide pyrophosphohydrolase
IRT44_14555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IRT44_14560	COG1803	Methylglyoxal synthase
IRT44_14565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRT44_14570	COG0438	transferase activity, transferring glycosyl groups
IRT44_14585	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IRT44_14590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IRT44_14595	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IRT44_14605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IRT44_14605	COG1199	ATP-dependent helicase activity
IRT44_14615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IRT44_14620	COG0402	S-adenosylhomocysteine deaminase activity
IRT44_14645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRT44_14655	COG0017	Asparaginyl-tRNA synthetase
IRT44_14660	COG3935	DnaD domain protein
IRT44_14685	COG0438	transferase activity, transferring glycosyl groups
IRT44_14695	COG1164	Oligoendopeptidase f
IRT44_14700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_14710	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_14715	COG1666	GTP binding
IRT44_14725	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_14730	COG0066	3-isopropylmalate dehydratase activity
IRT44_14735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IRT44_14740	COG0583	DNA-binding transcription factor activity
IRT44_14745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_14750	COG0564	pseudouridine synthase activity
IRT44_14755	COG0189	ligase activity
IRT44_14780	COG5002	protein histidine kinase activity
IRT44_14785	COG1054	Belongs to the UPF0176 family
IRT44_14810	COG0756	dUTP diphosphatase activity
IRT44_14815	COG2258	MOSC domain
IRT44_14820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IRT44_14825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IRT44_14830	COG4208	sulfate ABC transporter
IRT44_14840	COG0488	(ABC) transporter
IRT44_14845	COG2508	Transcriptional regulator
IRT44_14855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_14870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRT44_14870	COG3153	acetyltransferase
IRT44_14890	COG3829	transcription factor binding
IRT44_14890	COG3290	protein histidine kinase activity
IRT44_14895	COG0473	3-isopropylmalate dehydrogenase activity
IRT44_14900	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_14910	COG1122	ATPase activity
IRT44_14915	COG1122	ATPase activity
IRT44_14920	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IRT44_14925	COG4684	Psort location CytoplasmicMembrane, score
IRT44_14930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_14960	COG1215	transferase activity, transferring glycosyl groups
IRT44_14965	COG0745	RESPONSE REGULATOR receiver
IRT44_14980	COG1388	LysM domain
IRT44_14980	COG0791	NLP P60 protein
IRT44_15015	COG0791	NLP P60 protein
IRT44_15035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_15045	COG0492	ferredoxin-NADP+ reductase activity
IRT44_15050	COG0537	adenosine 5'-monophosphoramidase activity
IRT44_15055	COG3383	formate dehydrogenase (NAD+) activity
IRT44_15060	COG2427	Protein of unknown function (DUF1641)
IRT44_15065	COG5609	conserved protein (DUF2294)
IRT44_15070	COG3876	Protein conserved in bacteria
IRT44_15075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRT44_15080	COG1472	Belongs to the glycosyl hydrolase 3 family
IRT44_15090	COG0527	aspartate kinase activity
IRT44_15105	COG0813	purine-nucleoside phosphorylase activity
IRT44_15120	COG1686	Belongs to the peptidase S11 family
IRT44_15125	COG2357	RelA SpoT domain protein
IRT44_15150	COG0714	Associated with various cellular activities
IRT44_15160	COG3069	C4-dicarboxylate transmembrane transporter activity
IRT44_15180	COG1113	amino acid transport
IRT44_15200	COG2340	Cysteine-rich secretory protein family
IRT44_15205	COG0242	peptide deformylase activity
IRT44_15215	COG2364	Membrane
IRT44_15220	COG1846	Transcriptional regulator
IRT44_15230	COG2311	Membrane
IRT44_15235	COG1114	Component of the transport system for branched-chain amino acids
IRT44_15245	COG2233	PERMEase
IRT44_15250	COG4336	lyase activity
IRT44_15260	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IRT44_15265	COG1984	allophanate hydrolase subunit 2
IRT44_15270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IRT44_15285	COG0438	transferase activity, transferring glycosyl groups
IRT44_15290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRT44_15295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRT44_15300	COG1116	anion transmembrane transporter activity
IRT44_15305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IRT44_15310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_15315	COG2022	thiamine diphosphate biosynthetic process
IRT44_15320	COG2104	thiamine diphosphate biosynthetic process
IRT44_15330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IRT44_15340	COG1388	LysM domain
IRT44_15340	COG3858	chitin binding
IRT44_15350	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_15365	COG0482	sulfurtransferase activity
IRT44_15380	COG1361	Conserved repeat domain
IRT44_15380	COG3266	domain, Protein
IRT44_15380	COG2911	Protein conserved in bacteria
IRT44_15455	COG2843	Capsule synthesis protein
IRT44_15460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_15465	COG0785	Cytochrome C biogenesis protein
IRT44_15470	COG3852	Histidine kinase
IRT44_15475	COG3186	Phenylalanine-4-hydroxylase
IRT44_15485	COG0352	thiamine-phosphate diphosphorylase activity
IRT44_15490	COG0352	thiamine-phosphate diphosphorylase activity
IRT44_15525	COG4565	transcriptional regulatory protein
IRT44_15530	COG3290	protein histidine kinase activity
IRT44_15535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IRT44_15540	COG1953	Uracil, thiamine, allantoin
IRT44_15545	COG0840	transmembrane signaling receptor activity
IRT44_15575	COG0493	'glutamate synthase
IRT44_15595	COG2207	Transcriptional regulator
IRT44_15595	COG3708	Transcriptional regulator
IRT44_15600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IRT44_15605	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_15620	COG0464	growth
IRT44_15635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRT44_15640	COG0187	DNA topoisomerase II activity
IRT44_15645	COG0217	transcriptional regulatory protein
IRT44_15670	COG5002	protein histidine kinase activity
IRT44_15675	COG1090	epimerase
IRT44_15710	COG1595	DNA-templated transcription, initiation
IRT44_15715	COG0626	cystathionine gamma-synthase activity
IRT44_15720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IRT44_15725	COG3409	Peptidoglycan-binding domain 1 protein
IRT44_15725	COG3773	Cell wall hydrolase
IRT44_15735	COG2707	UPF0756 membrane protein
IRT44_15760	COG4848	Belongs to the UPF0354 family
IRT44_15770	COG0515	serine threonine protein kinase
IRT44_15790	COG4632	Exopolysaccharide biosynthesis protein
IRT44_15790	COG5434	Belongs to the glycosyl hydrolase 28 family
IRT44_15845	COG0531	amino acid
IRT44_15855	COG0316	Belongs to the HesB IscA family
IRT44_15860	COG3973	AAA domain
IRT44_15865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IRT44_15870	COG4224	UPF0291 protein
IRT44_15880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IRT44_15900	COG0174	glutamine synthetase
IRT44_15905	COG0789	Transcriptional regulator
IRT44_15910	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IRT44_15915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IRT44_15920	COG0464	growth
IRT44_15930	COG1923	regulation of RNA biosynthetic process
IRT44_15935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IRT44_15940	COG2521	methyltransferase
IRT44_15940	COG2136	Putative SAM-dependent methyltransferase
IRT44_15945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IRT44_15950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IRT44_15965	COG4550	Control of competence regulator ComK, YlbF/YmcA
IRT44_15970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRT44_15975	COG1361	Conserved repeat domain
IRT44_15980	COG0095	Lipoate-protein ligase
IRT44_15990	COG0517	IMP dehydrogenase activity
IRT44_16000	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IRT44_16005	COG1234	tRNA 3'-trailer cleavage
IRT44_16010	COG3949	Membrane
IRT44_16015	COG1013	pyruvate-flavodoxin oxidoreductase activity
IRT44_16020	COG0674	pyruvate-flavodoxin oxidoreductase activity
IRT44_16020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IRT44_16030	COG2359	stage V sporulation protein S
IRT44_16035	COG1692	metallophosphoesterase
IRT44_16040	COG3344	reverse transcriptase
IRT44_16050	COG2137	regulation of response to DNA damage stimulus
IRT44_16055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IRT44_16060	COG0513	Belongs to the DEAD box helicase family
IRT44_16070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IRT44_16075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRT44_16080	COG1426	Protein conserved in bacteria
IRT44_16095	COG0300	oxidoreductase activity
IRT44_16100	COG0612	Peptidase, M16
IRT44_16105	COG0612	Peptidase, M16
IRT44_16115	COG1079	Belongs to the binding-protein-dependent transport system permease family
IRT44_16120	COG4603	Belongs to the binding-protein-dependent transport system permease family
IRT44_16125	COG3845	ABC transporter
IRT44_16130	COG1744	ABC transporter substrate-binding protein PnrA-like
IRT44_16135	COG2188	Transcriptional regulator
IRT44_16150	COG0740	serine-type endopeptidase activity
IRT44_16160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IRT44_16165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRT44_16170	COG0527	aspartate kinase activity
IRT44_16175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IRT44_16180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IRT44_16185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRT44_16190	COG1873	PFAM PRC-barrel domain
IRT44_16195	COG0612	Peptidase, M16
IRT44_16200	COG0726	polysaccharide deacetylase
IRT44_16205	COG1185	polyribonucleotide nucleotidyltransferase activity
IRT44_16210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IRT44_16215	COG0196	riboflavin kinase activity
IRT44_16220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IRT44_16225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IRT44_16230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IRT44_16240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IRT44_16245	COG1358	cellular component organization or biogenesis
IRT44_16250	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IRT44_16255	COG0195	Participates in both transcription termination and antitermination
IRT44_16260	COG0779	Required for maturation of 30S ribosomal subunits
IRT44_16265	COG2176	DNA-directed DNA polymerase activity
IRT44_16270	COG0442	prolyl-tRNA aminoacylation
IRT44_16275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IRT44_16280	COG0750	zinc metalloprotease
IRT44_16285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IRT44_16290	COG4589	Belongs to the CDS family
IRT44_16295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IRT44_16300	COG0233	cytoplasmic translational termination
IRT44_16305	COG0528	UMP kinase activity
IRT44_16310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IRT44_16315	COG0052	Belongs to the universal ribosomal protein uS2 family
IRT44_16340	COG1191	sigma factor activity
IRT44_16350	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IRT44_16355	COG1776	CheC inhibitor of MCP methylation
IRT44_16360	COG0835	chemotaxis
IRT44_16365	COG2198	Histidine kinase
IRT44_16365	COG0643	Histidine kinase
IRT44_16370	COG2201	protein-glutamate methylesterase activity
IRT44_16375	COG0455	bacterial-type flagellum organization
IRT44_16380	COG1419	protein localization to endoplasmic reticulum
IRT44_16385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRT44_16390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRT44_16395	COG1684	flagellar biosynthetic protein fliR
IRT44_16400	COG1987	bacterial-type flagellum assembly
IRT44_16410	COG3190	flagellar
IRT44_16415	COG2201	protein-glutamate methylesterase activity
IRT44_16420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRT44_16420	COG1776	CheC inhibitor of MCP methylation
IRT44_16425	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRT44_16440	COG4786	Flagellar basal body rod
IRT44_16460	COG2882	bacterial-type flagellum organization
IRT44_16465	COG1157	protein secretion by the type III secretion system
IRT44_16475	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRT44_16480	COG1766	The M ring may be actively involved in energy transduction
IRT44_16485	COG1677	Flagellar hook-basal body complex protein FliE
IRT44_16490	COG1558	bacterial-type flagellum-dependent cell motility
IRT44_16495	COG1815	bacterial-type flagellum-dependent cell motility
IRT44_16500	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IRT44_16505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IRT44_16510	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IRT44_16515	COG4974	Belongs to the 'phage' integrase family
IRT44_16520	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IRT44_16525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IRT44_16530	COG0758	DNA mediated transformation
IRT44_16535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IRT44_16540	COG0045	succinate-CoA ligase (ADP-forming) activity
IRT44_16550	COG0393	Putative heavy-metal-binding
IRT44_16560	COG1737	Transcriptional regulator
IRT44_16570	COG0789	Transcriptional regulator
IRT44_16575	COG1664	Polymer-forming cytoskeletal
IRT44_16590	COG1414	Transcriptional regulator
IRT44_16610	COG0129	dihydroxy-acid dehydratase activity
IRT44_16615	COG4948	Mandelate Racemase Muconate Lactonizing
IRT44_16625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IRT44_16630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IRT44_16635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IRT44_16640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IRT44_16645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IRT44_16650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRT44_16655	COG2271	Major facilitator Superfamily
IRT44_16660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IRT44_16660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IRT44_16665	COG3591	Belongs to the peptidase S1B family
IRT44_16665	COG1864	DNA RNA non-specific endonuclease
IRT44_16690	COG2329	Antibiotic biosynthesis monooxygenase
IRT44_16695	COG2819	hydrolase of the alpha beta superfamily
IRT44_16700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_16705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_16710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_16715	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_16735	COG0243	molybdopterin cofactor binding
IRT44_16740	COG0697	spore germination
IRT44_16745	COG1620	l-lactate permease
IRT44_16755	COG0247	lactate metabolic process
IRT44_16760	COG0277	FAD linked oxidase domain protein
IRT44_16765	COG2186	Transcriptional regulator
IRT44_16770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IRT44_16850	COG0312	modulator of DNA gyrase
IRT44_16885	COG2207	Transcriptional regulator
IRT44_16885	COG3708	Transcriptional regulator
IRT44_16890	COG0662	Cupin 2, conserved barrel domain protein
IRT44_16895	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IRT44_16900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IRT44_16935	COG1280	lysine exporter protein (LysE YggA)
IRT44_16945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_16955	COG0488	(ABC) transporter
IRT44_16955	COG0488	(ABC) transporter
IRT44_16965	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IRT44_16995	COG0531	amino acid
IRT44_17000	COG2169	Transcriptional regulator
IRT44_17010	COG3328	transposase activity
IRT44_17015	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IRT44_17040	COG2135	peptidase activity
IRT44_17045	COG0024	Methionine aminopeptidase
IRT44_17050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_17055	COG1621	beta-fructofuranosidase activity
IRT44_17060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRT44_17060	COG1263	PTS System
IRT44_17065	COG1609	Transcriptional regulator
IRT44_17075	COG2814	Major facilitator Superfamily
IRT44_17080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRT44_17095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRT44_17095	COG5322	oxidoreductase activity
IRT44_17150	COG3708	Transcriptional regulator
IRT44_17150	COG2207	Transcriptional regulator
IRT44_17155	COG2132	Multicopper oxidase
IRT44_17160	COG2205	protein histidine kinase activity
IRT44_17165	COG0745	RESPONSE REGULATOR receiver
IRT44_17170	COG0477	Major facilitator Superfamily
IRT44_17180	COG2755	lipolytic protein G-D-S-L family
IRT44_17180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRT44_17185	COG2755	lipolytic protein G-D-S-L family
IRT44_17185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRT44_17190	COG0583	DNA-binding transcription factor activity
IRT44_17195	COG0655	NAD(P)H dehydrogenase (quinone) activity
IRT44_17210	COG0583	DNA-binding transcription factor activity
IRT44_17220	COG0436	Aminotransferase
IRT44_17225	COG1937	Protein conserved in bacteria
IRT44_17230	COG2210	Belongs to the sulfur carrier protein TusA family
IRT44_17235	COG0425	Belongs to the sulfur carrier protein TusA family
IRT44_17240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_17240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRT44_17245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRT44_17245	COG0425	Belongs to the sulfur carrier protein TusA family
IRT44_17250	COG0730	response to heat
IRT44_17280	COG2151	metal-sulfur cluster biosynthetic enzyme
IRT44_17290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IRT44_17310	COG0606	chelatase, subunit chli
IRT44_17320	COG2257	FlhB HrpN YscU SpaS Family
IRT44_17330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IRT44_17340	COG0681	Belongs to the peptidase S26 family
IRT44_17345	COG0335	large ribosomal subunit rRNA binding
IRT44_17350	COG0336	Belongs to the RNA methyltransferase TrmD family
IRT44_17355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IRT44_17365	COG1837	Belongs to the UPF0109 family
IRT44_17370	COG0228	four-way junction DNA binding
IRT44_17375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IRT44_17380	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IRT44_17430	COG0552	protein localization to endoplasmic reticulum
IRT44_17435	COG1196	nuclear chromosome segregation
IRT44_17445	COG0531	amino acid
IRT44_17455	COG3829	transcription factor binding
IRT44_17465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IRT44_17470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRT44_17475	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_17480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IRT44_17485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRT44_17490	COG0416	fatty acid biosynthetic process
IRT44_17495	COG1349	DNA-binding transcription factor activity
IRT44_17495	COG2050	protein possibly involved in aromatic compounds catabolism
IRT44_17500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IRT44_17510	COG3480	Lon protease (S16) C-terminal proteolytic domain
IRT44_17515	COG1752	Esterase of the alpha-beta hydrolase superfamily
IRT44_17520	COG3314	Sporulation integral membrane protein YlbJ
IRT44_17525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IRT44_17530	COG0742	ribosomal rna small subunit methyltransferase
IRT44_17540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRT44_17550	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IRT44_17565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IRT44_17570	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IRT44_17580	COG1793	dna ligase
IRT44_17600	COG0697	spore germination
IRT44_17605	COG1793	dna ligase
IRT44_17605	COG3285	dna ligase
IRT44_17610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IRT44_17620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_17625	COG4569	acetaldehyde dehydrogenase (acetylating) activity
IRT44_17640	COG0251	oxidation-reduction process
IRT44_17660	COG0431	NADPH-dependent FMN reductase
IRT44_17665	COG2368	4-hydroxyphenylacetate
IRT44_17675	COG0840	transmembrane signaling receptor activity
IRT44_17695	COG0306	phosphate transporter
IRT44_17705	COG3706	GGDEF domain
IRT44_17710	COG2814	Major facilitator Superfamily
IRT44_17715	COG3424	synthase
IRT44_17720	COG1755	Isoprenylcysteine carboxyl methyltransferase
IRT44_17735	COG1846	Transcriptional regulator
IRT44_17740	COG0681	Belongs to the peptidase S26 family
IRT44_17760	COG1876	peptidase activity
IRT44_17765	COG0405	Gamma-glutamyltransferase
IRT44_17770	COG5434	Belongs to the glycosyl hydrolase 28 family
IRT44_17770	COG4632	Exopolysaccharide biosynthesis protein
IRT44_17795	COG0714	Associated with various cellular activities
IRT44_17820	COG0438	transferase activity, transferring glycosyl groups
IRT44_17825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IRT44_17835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_17855	COG3546	catalase activity
IRT44_17880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IRT44_17895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IRT44_17900	COG1760	l-serine dehydratase
IRT44_17905	COG1760	l-serine dehydratase
IRT44_17910	COG1307	EDD domain protein, DegV family
IRT44_17915	COG1461	Dihydroxyacetone kinase
IRT44_17920	COG1302	Protein conserved in bacteria
IRT44_17925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IRT44_17935	COG3859	Proton-coupled thiamine transporter YuaJ
IRT44_17940	COG1126	abc transporter atp-binding protein
IRT44_17950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_17960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IRT44_17970	COG0515	serine threonine protein kinase
IRT44_17970	COG2815	serine threonine protein kinase
IRT44_17975	COG0631	protein serine/threonine phosphatase activity
IRT44_17980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IRT44_17985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IRT44_17985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRT44_17990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IRT44_17995	COG0242	peptide deformylase activity
IRT44_18000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IRT44_18005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IRT44_18010	COG1758	RNA polymerase activity
IRT44_18015	COG0194	GDP metabolic process
IRT44_18020	COG2052	Domain of unknown function (DUF370)
IRT44_18025	COG1561	YicC-like family, N-terminal region
IRT44_18055	COG1024	Enoyl-CoA hydratase
IRT44_18090	COG1547	Domain of unknown function (DUF309)
IRT44_18105	COG4846	Membrane protein involved in cytochrome C biogenesis
IRT44_18110	COG0531	amino acid
IRT44_18125	COG0477	Major facilitator Superfamily
IRT44_18130	COG1335	isochorismatase
IRT44_18135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IRT44_18140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IRT44_18145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IRT44_18150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRT44_18155	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IRT44_18160	COG0460	homoserine dehydrogenase
IRT44_18175	COG0284	orotidine-5'-phosphate decarboxylase activity
IRT44_18180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IRT44_18190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRT44_18195	COG0540	Belongs to the ATCase OTCase family
IRT44_18205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IRT44_18215	COG0564	pseudouridine synthase activity
IRT44_18220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IRT44_18225	COG2112	serine threonine protein kinase
IRT44_18230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRT44_18240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IRT44_18255	COG3546	catalase activity
IRT44_18285	COG1842	Phage shock protein A
IRT44_18290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IRT44_18310	COG1316	TRANSCRIPTIONal
IRT44_18315	COG0492	ferredoxin-NADP+ reductase activity
IRT44_18320	COG0494	nUDIX hydrolase
IRT44_18325	COG2814	Major facilitator Superfamily
IRT44_18330	COG4948	Mandelate Racemase Muconate Lactonizing
IRT44_18335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IRT44_18340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IRT44_18345	COG3599	regulation of cell shape
IRT44_18350	COG2302	S4 RNA-binding domain
IRT44_18355	COG0762	integral membrane protein
IRT44_18360	COG1799	cell septum assembly
IRT44_18365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IRT44_18370	COG1496	oxidoreductase activity
IRT44_18375	COG1873	PFAM PRC-barrel domain
IRT44_18380	COG1191	sigma factor activity
IRT44_18385	COG1191	sigma factor activity
IRT44_18400	COG1120	ATPase activity
IRT44_18405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_18410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_18425	COG2801	Transposase and inactivated derivatives
IRT44_18430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IRT44_18435	COG0849	cell division
IRT44_18440	COG3856	small basic protein
IRT44_18455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IRT44_18460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRT44_18465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IRT44_18475	COG0772	Belongs to the SEDS family
IRT44_18480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IRT44_18485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRT44_18495	COG0768	penicillin binding
IRT44_18500	COG0768	penicillin binding
IRT44_18510	COG0275	rRNA processing
IRT44_18515	COG2001	Belongs to the MraZ family
IRT44_18520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IRT44_18525	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IRT44_18530	COG1396	sequence-specific DNA binding
IRT44_18540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IRT44_18545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IRT44_18550	COG1024	Enoyl-CoA hydratase
IRT44_18555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_18560	COG0511	ligase activity, forming carbon-carbon bonds
IRT44_18565	COG0439	Biotin carboxylase
IRT44_18570	COG0454	-acetyltransferase
IRT44_18580	COG1024	Enoyl-CoA hydratase
IRT44_18585	COG1393	Belongs to the ArsC family
IRT44_18610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_18645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IRT44_18655	COG0626	cystathionine gamma-synthase activity
IRT44_18660	COG0626	cystathionine gamma-synthase activity
IRT44_18690	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IRT44_18700	COG1217	gtp-binding protein TYPA
IRT44_18705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IRT44_18730	COG4493	Belongs to the UPF0637 family
IRT44_18740	COG1982	Orn Lys Arg decarboxylase major
IRT44_18755	COG2267	carboxylic ester hydrolase activity
IRT44_18785	COG1473	amidohydrolase
IRT44_18790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRT44_18795	COG2171	N-acyltransferase activity
IRT44_18800	COG0716	FMN binding
IRT44_18810	COG2217	Heavy metal translocating P-type atpase
IRT44_18830	COG2226	methyltransferase
IRT44_18835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_18840	COG1136	(ABC) transporter
IRT44_18840	COG0577	efflux transmembrane transporter activity
IRT44_18845	COG1136	(ABC) transporter
IRT44_18845	COG0577	efflux transmembrane transporter activity
IRT44_18855	COG0351	phosphomethylpyrimidine kinase
IRT44_18860	COG2962	Rard protein
IRT44_18925	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IRT44_18930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_18935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_18940	COG3718	enzyme involved in inositol metabolism
IRT44_18945	COG1082	Xylose isomerase domain protein TIM barrel
IRT44_18950	COG3962	Belongs to the TPP enzyme family
IRT44_18955	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRT44_18960	COG1129	ABC transporter
IRT44_18970	COG0673	inositol 2-dehydrogenase activity
IRT44_18975	COG0673	inositol 2-dehydrogenase activity
IRT44_18980	COG1609	Transcriptional regulator
IRT44_18990	COG1695	Transcriptional regulator
IRT44_19020	COG1061	Type III restriction enzyme res subunit
IRT44_19030	COG0537	adenosine 5'-monophosphoramidase activity
IRT44_19045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_19070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IRT44_19090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IRT44_19110	COG3344	reverse transcriptase
IRT44_19125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IRT44_19140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IRT44_19150	COG0613	PHP domain protein
IRT44_19160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_19165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_19170	COG1253	flavin adenine dinucleotide binding