locus-tag class description GFC28_10 ENOG4108HNZ carboxyl transferase GFC28_1002 ENOG4105C6Z Gluconate GFC28_1003 ENOG4105CMG Carbohydrate kinase GFC28_1005 ENOG410645S MarR family Transcriptional regulator GFC28_1008 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GFC28_1009 ENOG4105CZ9 Domain of unknown function (DU1801) GFC28_1018 ENOG4106YBV Methyl-accepting chemotaxis GFC28_1022 ENOG4108MJI response regulator GFC28_1026 ENOG4107VFR oxidoreductase GFC28_1028 ENOG4108Z5V transcriptional regulator, merr family GFC28_1029 ENOG4105D7K pfkb domain protein GFC28_103 ENOG4105C9U ATP-dependent DNA helicase RecQ GFC28_1030 ENOG4108UHU Aldolase GFC28_1031 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GFC28_1032 ENOG4105CK5 oxidoreductase GFC28_1035 ENOG4105KK4 UPF0060 membrane protein GFC28_1037 ENOG4108JPW Aminotransferase GFC28_104 ENOG4105I7S Abortive infection protein GFC28_1042 ENOG4105EU0 Major facilitator Superfamily GFC28_1044 ENOG4105C26 Dehydrogenase GFC28_1045 ENOG4107YHD transcriptional regulator GFC28_1048 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GFC28_1050 ENOG4105DEF Extracellular solute-binding protein, family 5 GFC28_1052 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC28_1053 ENOG4108JQ7 (ABC) transporter GFC28_1055 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_1057 ENOG4108HWW ABC transporter GFC28_1058 ENOG4105C2J ABC transporter GFC28_1059 ENOG4105DFW ABC transporter GFC28_1060 ENOG4108VAC response regulator GFC28_1061 ENOG4105C2F Histidine kinase GFC28_1062 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator GFC28_1063 ENOG4105BZU Histidine kinase GFC28_107 ENOG4105WEF catalase GFC28_1070 ENOG41081VK Ribonuclease GFC28_1075 ENOG4108I0Z Aconitate hydratase GFC28_1076 ENOG410746C Acid-soluble spore protein O GFC28_1078 ENOG41076DU acid-soluble spore protein P GFC28_1079 ENOG4105F0V Cell wall hydrolase GFC28_1082 ENOG4107YTP response regulator receiver protein GFC28_1083 ENOG4107QIV Cytochrome c biogenesis protein GFC28_1085 ENOG4105VXM UPF0154 protein GFC28_1088 ENOG4105VPS UPF0291 protein GFC28_1089 ENOG4108SVB resolvase GFC28_1090 ENOG41067Z0 domain protein GFC28_1091 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GFC28_1100 ENOG41068KG domain protein GFC28_1101 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GFC28_1105 ENOG41063SB peptidase GFC28_1106 ENOG4105D5G Transposase GFC28_1107 ENOG4105K59 histidine triad (HIT) protein GFC28_1108 ENOG4105C5F glutamine synthetase GFC28_1109 ENOG4105KV4 Transcriptional regulator GFC28_111 ENOG4107RGJ metallophosphoesterase GFC28_1110 ENOG4105CXI aluminum resistance protein GFC28_1111 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GFC28_1112 ENOG4105EN6 Membrane GFC28_1113 ENOG4105CHU acetyl-coa acetyltransferase GFC28_1114 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC28_1115 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_1119 ENOG4106F1P AAA ATPase, central domain protein GFC28_112 ENOG4108S6Z Negative regulator of genetic competence GFC28_1120 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GFC28_1121 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GFC28_1122 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_1123 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC28_1129 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GFC28_1130 ENOG4105KTB nuclear export factor GLE1 GFC28_1131 ENOG4108T5E Copper resistance protein GFC28_1132 ENOG4108JYZ YitT family GFC28_1134 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GFC28_1139 ENOG4105CIG ABC transporter GFC28_114 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GFC28_1140 ENOG4105K4I Scp-like extracellular GFC28_1143 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GFC28_1146 ENOG4106KNT transcriptional regulator GFC28_1147 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GFC28_1148 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GFC28_115 ENOG4105HDK L-asparaginase GFC28_1152 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GFC28_1153 ENOG4105DQU oxidoreductase, subunit beta GFC28_1154 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GFC28_1156 ENOG4105MCT stage V sporulation protein S GFC28_1157 ENOG4105D48 metallophosphoesterase GFC28_1158 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GFC28_116 ENOG4105Y38 Kinase-associated protein B GFC28_1160 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GFC28_1161 ENOG4105CEV competence damage-inducible protein GFC28_1162 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GFC28_1165 ENOG4105XZV Protein of unknown function (DUF3243) GFC28_1166 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GFC28_1170 ENOG4105UIB (ABC) transporter GFC28_1171 ENOG4108JQ9 ABC transporter GFC28_1172 ENOG4105DIH basic membrane GFC28_1173 ENOG4105FDP GntR family transcriptional regulator GFC28_1174 ENOG4105CNU cell division protein FtsK GFC28_1176 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GFC28_1178 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GFC28_1180 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GFC28_1181 ENOG4108S0H Dipicolinic acid synthetase, b subunit GFC28_1182 ENOG4105E35 Dipicolinate synthase subunit A GFC28_1184 ENOG4105C1V Peptidase, M16 GFC28_1186 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GFC28_1187 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GFC28_1188 ENOG4105DTN riboflavin biosynthesis protein ribF GFC28_1189 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GFC28_119 ENOG41067SE Tetr family transcriptional regulator GFC28_1190 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GFC28_1191 ENOG4105W7A Protein of unknown function (DUF503) GFC28_1192 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GFC28_1193 ENOG4105VHM ribosomal protein GFC28_1194 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GFC28_1195 ENOG4105CHV Transcription elongation factor NusA GFC28_1196 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GFC28_1197 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GFC28_1198 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GFC28_1199 ENOG4105DZP Membrane-associated zinc metalloprotease GFC28_12 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GFC28_1200 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GFC28_1201 ENOG4105KNE Phosphatidate cytidylyltransferase GFC28_1202 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GFC28_1203 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GFC28_1204 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GFC28_1205 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GFC28_1206 ENOG4105CE9 30S ribosomal protein S2 GFC28_1209 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC28_121 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) GFC28_1211 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GFC28_1213 ENOG4108V3W Chemotaxis protein, CheW GFC28_1214 ENOG4105CBS Chea signal transduction histidine kinase GFC28_1215 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GFC28_1217 ENOG4105FZW flagellar biosynthesis regulator FlhF GFC28_1218 ENOG4105D7B Flagellar biosynthesis protein flha GFC28_1219 ENOG4105D00 flagellar biosynthetic protein flhB GFC28_122 ENOG4105F0V Cell wall hydrolase GFC28_1220 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GFC28_1221 ENOG4105VS8 Flagellar biosynthetic protein fliq GFC28_1222 ENOG4105CN7 Flagellar biosynthetic protein FliP GFC28_1224 ENOG4107YTP response regulator receiver protein GFC28_1225 ENOG4105DD5 Flagellar motor switch protein GFC28_1226 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GFC28_1228 ENOG41068WV flagellar FlbD family protein GFC28_1229 ENOG4108JQA flagellar GFC28_123 ENOG4105MSI germination protein ypeb GFC28_1230 ENOG410822I Flagellar hook capping protein GFC28_1231 ENOG410696Y Flagellar hook-length control protein GFC28_1233 ENOG4106YF4 Flagellar biosynthesis chaperone GFC28_1236 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GFC28_1237 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GFC28_1238 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GFC28_1239 ENOG4108ZC9 flagellar basal-body rod protein flgc GFC28_1240 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GFC28_1241 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) GFC28_1242 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GFC28_1243 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GFC28_1244 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC28_1245 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GFC28_1246 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GFC28_1247 ENOG4105C79 DNA protecting protein DprA GFC28_1248 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GFC28_1249 ENOG4105CMV Succinyl-CoA synthetase subunit beta GFC28_1250 ENOG4105D00 flagellar biosynthetic protein flhB GFC28_1252 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GFC28_1253 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GFC28_1255 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GFC28_1256 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GFC28_1257 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GFC28_1259 ENOG4105VB6 UPF0109 protein GFC28_126 ENOG4105CAT Cytidine monophosphate kinase GFC28_1260 ENOG4105K5M 30s ribosomal protein S16 GFC28_1262 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GFC28_1263 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GFC28_1264 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GFC28_1265 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GFC28_1266 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GFC28_1267 ENOG4105CHR reductase GFC28_1268 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GFC28_1269 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GFC28_127 ENOG4105F6E Acyl-transferase GFC28_1270 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GFC28_1271 ENOG4105CB5 ATP-dependent DNA helicase recG GFC28_1272 ENOG4105EJQ L-serine dehydratase GFC28_1274 ENOG4105DP4 dak2 domain fusion protein ylov GFC28_1275 ENOG4108ZAA Alkaline-shock protein GFC28_1276 ENOG4105VB9 50S ribosomal protein l28 GFC28_1277 ENOG4105FJ0 thiamine GFC28_1278 ENOG4105DJV ribulose-phosphate 3-epimerase GFC28_1279 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GFC28_128 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GFC28_1280 ENOG4105D9P serine threonine protein kinase GFC28_1281 ENOG4108ZF3 Phosphatase GFC28_1282 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GFC28_1283 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GFC28_1284 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GFC28_1285 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GFC28_1286 ENOG4105C25 Primosomal protein n' GFC28_1287 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GFC28_1288 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GFC28_1289 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GFC28_129 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GFC28_1290 ENOG4105KC4 UPF0296 protein GFC28_1291 ENOG4105DSJ YicC domain protein GFC28_1293 ENOG4105F23 Fibronectin-binding protein GFC28_1296 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GFC28_1297 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GFC28_1298 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GFC28_13 ENOG4108V3W Chemotaxis protein, CheW GFC28_1301 ENOG4105CD3 dihydroorotase GFC28_1302 ENOG4105CXT aspartate transcarbamylase GFC28_1304 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GFC28_1305 ENOG4105C34 Pseudouridine synthase GFC28_1306 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GFC28_1307 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GFC28_1309 ENOG4105DBK s4 domain protein GFC28_1310 ENOG41067XK integral membrane protein GFC28_1311 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GFC28_1312 ENOG4105DFA alanine racemase domain protein GFC28_1313 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GFC28_1314 ENOG4105WR5 sporulation protein, YlmC YmxH family GFC28_1316 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC28_1317 ENOG4108AWX Sporulation factor SpoIIGA GFC28_1318 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GFC28_1319 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GFC28_1320 ENOG4105K67 small basic protein GFC28_1322 ENOG4108R2U division initiation protein GFC28_1323 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GFC28_1324 ENOG4105D4A Cell wall formation (By similarity) GFC28_1325 ENOG4105CNI cell division protein FtsW GFC28_1326 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GFC28_1327 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GFC28_1329 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GFC28_133 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GFC28_1330 ENOG4105CJN penicillin-binding protein GFC28_1331 ENOG4105CJN penicillin-binding protein GFC28_1332 ENOG41068DC Essential cell division protein (By similarity) GFC28_1333 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GFC28_1334 ENOG41074B2 UPF0747 protein GFC28_1338 ENOG4105E39 Enoyl-CoA hydratase GFC28_1339 ENOG41067VY 50S ribosomal protein L32 GFC28_134 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GFC28_1340 ENOG4105KNH Nucleic acid-binding protein GFC28_1341 ENOG41063PX domain protein GFC28_1342 ENOG4105CDE UPF0348 protein GFC28_1343 ENOG4105D78 K07001 NTE family protein GFC28_1344 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GFC28_1345 ENOG4106H78 methyltransferase GFC28_1348 ENOG4105WUC UPF0298 protein GFC28_1353 ENOG4106UY4 Inherit from COG: Scp-like extracellular GFC28_1354 ENOG41080XQ Signal transduction protein with cbs domains GFC28_1355 ENOG4105K4I Scp-like extracellular GFC28_1364 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GFC28_1365 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GFC28_1366 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GFC28_1367 ENOG4105CNI cell division protein FtsW GFC28_1368 ENOG4105ZPI UPF0358 protein GFC28_137 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GFC28_1370 ENOG4108IAB Phoh family GFC28_1375 ENOG4105QA2 GFC28_1376 ENOG4105CI3 gtp-binding protein typa GFC28_1378 ENOG4105ECY inositol monophosphatase GFC28_1380 ENOG4105WBI UPF0223 protein GFC28_1381 ENOG4105EA8 2-Nitropropane dioxygenase GFC28_1382 ENOG4105CXN decarboxylase GFC28_139 ENOG4105EUJ GTP cyclohydrolase i GFC28_1393 ENOG4108X4Q Hydrolase GFC28_1395 ENOG4106148 UPF0356 protein GFC28_1396 ENOG4105CN5 Metallo-Beta-Lactamase GFC28_1397 ENOG4107ZYR domain protein GFC28_1398 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC28_1399 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC28_140 ENOG4105WP2 Tryptophan RNA-binding attenuator protein GFC28_1400 ENOG4105D3R alkyl hydroperoxide reductase GFC28_1401 ENOG4106AUC UPF0180 protein GFC28_1402 ENOG4105CH2 amidohydrolase GFC28_1403 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GFC28_1409 ENOG4107IN1 Protein of unknown function (DUF1797) GFC28_1411 ENOG4105EPM Diguanylate phosphodiesterase GFC28_1413 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GFC28_1415 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GFC28_1416 ENOG4107R33 ppx gppa phosphatase GFC28_1417 ENOG4105UIN GFC28_1418 ENOG4107R88 Chemotaxis protein (CheV) GFC28_142 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GFC28_1420 ENOG4108HGU Histidine kinase GFC28_1423 ENOG4105D7N magnesium and cobalt transport protein CorA GFC28_1425 ENOG4105CHM Aminotransferase GFC28_1426 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GFC28_1427 ENOG4105YB8 TM2 domain containing protein GFC28_1428 ENOG4105CHR reductase GFC28_1429 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GFC28_1433 ENOG4105CID antiterminator GFC28_1435 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GFC28_1436 ENOG4107RWR Sodium hydrogen exchanger GFC28_144 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GFC28_1443 ENOG4105BZU Histidine kinase GFC28_145 ENOG4105BZU Histidine kinase GFC28_1450 ENOG4105F0V Cell wall hydrolase GFC28_1452 ENOG4105K4T epimerase GFC28_1453 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GFC28_1455 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GFC28_1456 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase GFC28_1457 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GFC28_1458 ENOG4108B31 Spore germination protein GFC28_146 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GFC28_1462 ENOG4108K88 Membrane GFC28_1467 ENOG4108IV0 ABC, transporter GFC28_1468 ENOG4105C0Z ABC transporter GFC28_147 ENOG4105D49 3-dehydroquinate synthase GFC28_1470 ENOG4105C32 Amino acid ABC transporter (Permease) GFC28_1473 ENOG4105CJ1 ABC, transporter GFC28_1475 ENOG4105D5Q Arginine ornithine antiporter GFC28_1476 ENOG41090MY MarR family Transcriptional regulator GFC28_1477 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GFC28_1478 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GFC28_1479 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) GFC28_148 ENOG4105KHN chorismate mutase GFC28_1480 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GFC28_1482 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GFC28_1483 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GFC28_1484 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GFC28_1485 ENOG4105FCA ABC transporter periplasmic-binding protein YphF GFC28_1486 ENOG4105C2J ABC transporter GFC28_1487 ENOG4108HWV )-transporter GFC28_1489 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GFC28_1490 ENOG4105BZU Histidine kinase GFC28_1495 ENOG4105E2A Dehydrogenase GFC28_1498 ENOG4105DRS transport system, permease GFC28_150 ENOG4108I0Q anthranilate phosphoribosyltransferase GFC28_1500 ENOG4108JE9 extracellular solute-binding protein family 1 GFC28_1502 ENOG4107KJX Transcriptional regulator GFC28_1503 ENOG410681C small acid-soluble spore protein GFC28_1505 ENOG4105CUB amino acid GFC28_1509 ENOG4105DTQ mandelate racemase muconate lactonizing GFC28_151 ENOG4105DK0 Indole-3-glycerol phosphate synthase GFC28_1513 ENOG4105DWK Membrane GFC28_1514 ENOG4105NCW Trka-c domain protein GFC28_1515 ENOG4107S91 Sodium hydrogen exchanger GFC28_1516 ENOG4107HP6 Transcriptional regulator GFC28_1517 ENOG4105ERH Fumarylacetoacetate hydrolase GFC28_1518 ENOG4105C82 Malate synthase GFC28_1519 ENOG4105CQB FAD linked oxidase domain protein GFC28_152 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GFC28_1520 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC28_1521 ENOG4105CQB FAD linked oxidase domain protein GFC28_154 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GFC28_1542 ENOG4108N3W hemolysin secretion protein GFC28_1543 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GFC28_1547 ENOG4105ENE Histidine kinase GFC28_1548 ENOG4105WH1 Two component transcriptional regulator luxr family GFC28_155 ENOG4105CIH Imidazole acetol-phosphate transaminase GFC28_1550 ENOG4105CV8 reductase GFC28_1551 ENOG4105F27 Major Facilitator GFC28_1552 ENOG4105KVH Transcriptional regulator GFC28_1554 ENOG4108IJ0 Aspartate ammonia-lyase GFC28_1555 ENOG4105HDK L-asparaginase GFC28_1556 ENOG4108IMY Transcriptional regulator GFC28_1557 ENOG4108RCF TRANSCRIPTIONal GFC28_1559 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GFC28_1560 ENOG4105ES4 Nitrilase GFC28_1561 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GFC28_1564 ENOG4105DWT malate dehydrogenase (quinone) GFC28_1567 ENOG4105ERH Fumarylacetoacetate hydrolase GFC28_157 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GFC28_1571 ENOG4105DTN riboflavin biosynthesis protein ribF GFC28_1576 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GFC28_1577 ENOG4106P55 Transcriptional regulator GFC28_1579 ENOG4105M6F mutator MutT protein GFC28_1581 ENOG4105CSV Glutaminase GFC28_1588 ENOG4105DQ5 transport system permease protein GFC28_1589 ENOG4105TVJ transport system, permease GFC28_159 ENOG41068YB TPR repeat-containing protein GFC28_1590 ENOG4105E0A ABC, transporter GFC28_1591 ENOG4105NX3 Membrane GFC28_1592 ENOG4105VMP Transcriptional regulator GFC28_1595 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase GFC28_1603 ENOG4105C9Q fumarate hydratase class II GFC28_1604 ENOG4105FBA Phospholipase Carboxylesterase GFC28_1605 ENOG4105FGM Fructosamine kinase GFC28_1606 ENOG4105IIP Membrane GFC28_1607 ENOG4105DT3 PTS system, galactitol-specific IIc component GFC28_1608 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GFC28_1610 ENOG4107RHR regulatoR GFC28_1612 ENOG4105C7S Dehydrogenase GFC28_1613 ENOG4105CPP Dehydrogenase, E1 component GFC28_1614 ENOG4107RUY (E1 component), alpha subunit GFC28_1615 ENOG4107RHR regulatoR GFC28_1616 ENOG4105VI0 Pts system, glucitol sorbitol-specific GFC28_1617 ENOG4105DZY Pts system, glucitol sorbitol-specific GFC28_1618 ENOG410787A Pts system, glucitol sorbitol-specific GFC28_162 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GFC28_1625 ENOG4108SU4 UPF0309 protein GFC28_163 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GFC28_1633 ENOG4106ETB IIa component GFC28_1634 ENOG4106ETB IIa component GFC28_1639 ENOG4107QM2 Aldo Keto reductase GFC28_164 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit GFC28_1640 ENOG4108F3G Type I restriction-modification system, R subunit GFC28_1641 ENOG4105M6F mutator MutT protein GFC28_1652 ENOG4105CAQ asparagine synthetase GFC28_1654 ENOG4107R16 Multicopper oxidase GFC28_1658 ENOG4107QIV Cytochrome c biogenesis protein GFC28_1659 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC28_1660 ENOG4105CRE cytochrome C GFC28_1661 ENOG4107TWT Cytochrome c biogenesis protein GFC28_1667 ENOG4105BZU Histidine kinase GFC28_1668 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC28_167 ENOG4108JYZ YitT family GFC28_1672 ENOG4105C59 p-type ATPase GFC28_1673 ENOG4105VPX protein, conserved in bacteria GFC28_168 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GFC28_1683 ENOG4105PGM cation diffusion facilitator family transporter GFC28_1688 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GFC28_169 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GFC28_1692 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC28_1695 ENOG4108ZRV stage ii sporulation protein p GFC28_17 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GFC28_170 ENOG4108Z5K methylglyoxal synthase GFC28_1701 ENOG4105K4H Nlp p60 protein GFC28_1703 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC28_1704 ENOG4105BZU Histidine kinase GFC28_1705 ENOG4105CUB amino acid GFC28_171 ENOG4105FJR Lmbe family GFC28_1714 ENOG4105CDA abc transporter atp-binding protein GFC28_1715 ENOG4105E5Q amino acid AbC transporter GFC28_1716 ENOG4105EAB amino acid AbC transporter GFC28_172 ENOG4105CPK Glycosyl transferase (Group 1 GFC28_173 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GFC28_1733 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC28_1738 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) GFC28_1742 ENOG4105DUM transcriptional regulator, lysR family GFC28_1745 ENOG4105C28 cystathionine GFC28_1746 ENOG4105C28 cystathionine GFC28_1747 ENOG4105DTD Dehydrogenase GFC28_1748 ENOG4105CY2 Citrate transporter GFC28_175 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GFC28_1752 ENOG4108ZMI UPF0477 protein GFC28_1753 ENOG41082BV acetyltransferase GFC28_1756 ENOG4105ENA helicase GFC28_176 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GFC28_1760 ENOG4105SZ6 Thioredoxin GFC28_1762 ENOG4108QY0 Membrane GFC28_1765 ENOG4105CZ3 stage V sporulation protein ad GFC28_1766 ENOG41090VF Stage v sporulation protein ac GFC28_177 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GFC28_1776 ENOG4108IAJ Nad-dependent epimerase dehydratase GFC28_1777 ENOG4107SBE Glycosyl transferase (Group 1 GFC28_1778 ENOG4107SBE Glycosyl transferase (Group 1 GFC28_1779 ENOG4108KS4 Spore coat protein GFC28_178 ENOG4105DVT helicase GFC28_1782 ENOG4105CNI cell division protein FtsW GFC28_1783 ENOG4107S1Q Phosphatase GFC28_1784 ENOG4105EMS pseudouridine synthase GFC28_1785 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GFC28_1787 ENOG4106EFP UPF0738 protein GFC28_1788 ENOG4105MIX Adenylate cyclase GFC28_1789 ENOG4105E4C Lytic transglycosylase catalytic GFC28_179 ENOG4105YAC GFC28_1790 ENOG4108Z18 K06886 hemoglobin GFC28_1791 ENOG4105T58 Dithiol-disulfide isomerase GFC28_1793 ENOG4105DPN Oligoendopeptidase f GFC28_1795 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GFC28_1796 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis GFC28_1797 ENOG4108ZCF integral membrane protein GFC28_1798 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GFC28_1800 ENOG4108JQ7 (ABC) transporter GFC28_1802 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GFC28_1803 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC28_1804 ENOG4108J59 Extracellular solute-binding protein, family 5 GFC28_1806 ENOG4108KU1 UPF0736 protein GFC28_1809 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GFC28_1810 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GFC28_1815 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GFC28_1817 ENOG4105DBV ornithine carbamoyltransferase GFC28_182 ENOG4105C5S asparaginyl-tRNA synthetase GFC28_1821 ENOG4105CAS nag kinase GFC28_1822 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GFC28_1823 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GFC28_1825 ENOG4108ZAF Molybdopterin GFC28_1826 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GFC28_1827 ENOG4105CVM Molybdenum cofactor synthesis domain protein GFC28_1828 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GFC28_1829 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GFC28_1830 ENOG4108MXZ Esterase GFC28_1831 ENOG4108KP7 hydrolase GFC28_1833 ENOG4107AYK membrAne GFC28_1834 ENOG4105EPR degv family GFC28_1836 ENOG4105WH1 Two component transcriptional regulator luxr family GFC28_1837 ENOG4105BZU Histidine kinase GFC28_1838 ENOG4105CJ1 ABC, transporter GFC28_184 ENOG4105CSM endonuclease III GFC28_1840 ENOG4108KYE ABC-2 type transporter GFC28_1841 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_1842 ENOG4105DIH basic membrane GFC28_1843 ENOG4105QNR S1 RNA binding domain protein GFC28_1844 ENOG4108VPT UPF0234 protein GFC28_1848 ENOG4105ETE Transcriptional regulator (LacI family GFC28_1850 ENOG4108IUK alpha amylase, catalytic GFC28_1851 ENOG4105EG2 ABC transporter, permease GFC28_1853 ENOG4107FKK extracellular solute-binding protein family 1 GFC28_1855 ENOG4106HBX Transcriptional Regulator AraC Family GFC28_1856 ENOG4105UQX Mate efflux family protein GFC28_1857 ENOG4105CAQ asparagine synthetase GFC28_1859 ENOG4105YHS UPF0344 protein GFC28_186 ENOG4105BZ4 penicillin-binding protein GFC28_1860 ENOG4105C8Y Acetylornithine aminotransferase GFC28_1861 ENOG4105ERH Fumarylacetoacetate hydrolase GFC28_1863 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_187 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GFC28_1872 ENOG4105EYH Exonuclease GFC28_1874 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GFC28_1875 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination GFC28_1878 ENOG4105XVF Competence transcription factor GFC28_1882 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GFC28_1885 ENOG4108UMN azlc family GFC28_1886 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_1887 ENOG4108RQ5 Beta-lactamase domain-containing protein GFC28_1888 ENOG4106AXD GFC28_1891 ENOG4107T3P ABC, transporter GFC28_1893 ENOG4105ECB domain protein GFC28_1895 ENOG4105C1Q protoporphyrinogen oxidase GFC28_1896 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GFC28_1897 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GFC28_1900 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GFC28_1903 ENOG4105K59 histidine triad (HIT) protein GFC28_1904 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GFC28_1906 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) GFC28_1909 ENOG4105NBU tryptophan transport protein GFC28_1910 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GFC28_1912 ENOG4105EQI Metal Dependent Phosphohydrolase GFC28_1913 ENOG4105RHA ABC transporter, permease GFC28_1914 ENOG4108IUX (ABC) transporter GFC28_1916 ENOG4105D4P Coproporphyrinogen iii oxidase GFC28_1918 ENOG4105WZB UPF0342 protein GFC28_1919 ENOG4108UH6 UPF0754 membrane protein GFC28_192 ENOG4106DDH Sporulation-specific SASP protein GFC28_1926 ENOG4105CDA abc transporter atp-binding protein GFC28_1927 ENOG4105DRP amino acid AbC transporter GFC28_1929 ENOG4105C37 (CBS) domain GFC28_1931 ENOG4105D06 uba thif-type nad fad binding protein GFC28_1932 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GFC28_1934 ENOG41080HI glycine oxidase GFC28_1935 ENOG4108VEU Thiamine monophosphate synthase GFC28_1936 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GFC28_1937 ENOG4108JJB ABC transporter GFC28_1939 ENOG4105ETU transcriptional activator (TenA GFC28_1940 ENOG4105DR4 Methyltransferase GFC28_1941 ENOG4108YYS metal-dependent hydrolase (By similarity) GFC28_1943 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GFC28_1944 ENOG4105VCD cytoplasmic protein GFC28_1945 ENOG4105D22 carbon starvation protein GFC28_1947 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GFC28_1948 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GFC28_1949 ENOG4108ZCF integral membrane protein GFC28_195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC28_1951 ENOG4105NQC Flavodoxin GFC28_1952 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GFC28_1953 ENOG41087NI Sulfite exporter TauE/SafE GFC28_1954 ENOG4107TPS domain protein GFC28_1955 ENOG4105VFE sira family GFC28_1957 ENOG4105C72 UPF0176 protein GFC28_1958 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GFC28_1959 ENOG4105VFE sira family GFC28_196 ENOG4105GR3 Histidine kinase GFC28_1960 ENOG4105XTG Pfam:DUF156 GFC28_1963 ENOG4105ED1 spovr family GFC28_1965 ENOG41069DP small acid-soluble spore protein GFC28_1967 ENOG4107ZTW SNARE associated Golgi GFC28_1972 ENOG4105WH1 Two component transcriptional regulator luxr family GFC28_1973 ENOG4105BZU Histidine kinase GFC28_1974 ENOG4105EMU Dehydrogenase GFC28_1976 ENOG41080XP Cbs domain GFC28_1977 ENOG4105CG3 alpha amylase, catalytic region GFC28_198 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GFC28_1981 ENOG4108YBP pseudouridine synthase GFC28_1982 ENOG4105C37 (CBS) domain GFC28_1984 ENOG4105D7V transposase GFC28_1987 ENOG4105CS1 NAD(P)H quinone oxidoreductase GFC28_1988 ENOG4105C2I pirin domain protein GFC28_1989 ENOG4107QJT sodium dicarboxylate symporter GFC28_1990 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GFC28_1991 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GFC28_1992 ENOG4108MRH transcriptional regulatory protein GFC28_1994 ENOG41062D9 Histidine kinase GFC28_1995 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GFC28_1996 ENOG4105C19 ABC transporter GFC28_1998 ENOG4105C3F Signal peptidase i GFC28_2 ENOG4108Y6J UPF0403 protein GFC28_20 ENOG4107XCH Cyclase family GFC28_200 ENOG4105EU9 GFC28_2000 ENOG4105CYN Serine protein kinase GFC28_2002 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GFC28_2004 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GFC28_201 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GFC28_202 ENOG4105CMR udp-glucose 4-epimerase GFC28_203 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase GFC28_2036 ENOG4105TUA UPF0295 protein GFC28_2037 ENOG4105G5W regulator Fur family GFC28_2038 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC28_2042 ENOG4108IUW ABC transporter GFC28_2043 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GFC28_2044 ENOG4105CBC glutamate synthase GFC28_2048 ENOG4107NBY Membrane GFC28_205 ENOG4105MYT Heat shock protein GFC28_2050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GFC28_2051 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC28_2052 ENOG4105DEF Extracellular solute-binding protein, family 5 GFC28_2053 ENOG4108JQ7 (ABC) transporter GFC28_2054 ENOG4105C3U ABC transporter GFC28_2055 ENOG4105EVI UPF0374 protein GFC28_2058 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GFC28_2059 ENOG4106BXE GFC28_206 ENOG4105BZU Histidine kinase GFC28_2061 ENOG41067AE Membrane-bound metal-dependent hydrolase GFC28_2064 ENOG4105XHU Acid-soluble spore protein K GFC28_2067 ENOG4105CHR reductase GFC28_2068 ENOG410902V Modulates RecA activity (By similarity) GFC28_2069 ENOG4105ECP epimerase GFC28_2075 ENOG4105WH1 Two component transcriptional regulator luxr family GFC28_2077 ENOG4108S4H thioesterase Superfamily protein GFC28_2078 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GFC28_208 ENOG4105BZU Histidine kinase GFC28_2081 ENOG4105DXD 2-methylcitrate dehydratase GFC28_2082 ENOG4105CR4 methylisocitrate lyase GFC28_2085 ENOG4105C8J )-transporter GFC28_2094 ENOG4105CNG UPF0061 protein GFC28_2095 ENOG4105D7V transposase GFC28_21 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GFC28_2108 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GFC28_2116 ENOG4105UPD Calcium Proton GFC28_2118 ENOG4108ISG Major Facilitator GFC28_2120 ENOG4107U9T Pfam:Ribonuclease_BN GFC28_2122 ENOG4105KJF protein tyrosine phosphatase GFC28_2123 ENOG41068PA UPF0435 protein GFC28_2125 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GFC28_2127 ENOG4107RIQ Sulfate adenylate transferase GFC28_2128 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GFC28_2129 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GFC28_2131 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GFC28_2132 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GFC28_2133 ENOG410855V Acylphosphatase GFC28_2136 ENOG4108TN2 lmbE family GFC28_2137 ENOG4108Z73 Siroheme synthase GFC28_2144 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC28_2145 ENOG4105CQB FAD linked oxidase domain protein GFC28_2146 ENOG4105DAA L-lactate GFC28_2147 ENOG4105JXH GntR family transcriptional regulator GFC28_2148 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC28_2149 ENOG4107QR9 Iron-sulfur cluster binding protein GFC28_2150 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) GFC28_2151 ENOG4108ZCF integral membrane protein GFC28_2152 ENOG4105CI2 imidazolone-5-propionate hydrolase GFC28_2153 ENOG4105CGP Urocanate hydratase GFC28_2154 ENOG4105C84 Histidine ammonia-lyase GFC28_2155 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) GFC28_2159 ENOG4105XRQ Xanthine dehydrogenase accessory factor GFC28_2161 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GFC28_2164 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GFC28_2165 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_2166 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GFC28_2169 ENOG4105C0H protease GFC28_2173 ENOG4105CYC Transferase GFC28_2175 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GFC28_2179 ENOG4105YA8 Transcriptional regulator GFC28_2182 ENOG4108RDQ ABC transporter GFC28_2188 ENOG4105NAE bifunctional deaminase-reductase domain protein GFC28_2191 ENOG4108NEV two component transcriptional regulator, LytTR family GFC28_2195 ENOG4105CBD Diacylglycerol kinase GFC28_22 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GFC28_2200 ENOG4105DZ6 Band 7 protein GFC28_2203 ENOG4105BZU Histidine kinase GFC28_2207 ENOG4107RUE extracellular solute-binding protein family 1 GFC28_2208 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component GFC28_2209 ENOG4105F38 ABC transporter, permease GFC28_2210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GFC28_2217 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) GFC28_2218 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GFC28_2225 ENOG4105E90 ABC transporter GFC28_2226 ENOG4108IJ8 ABC transporter GFC28_2227 ENOG4108HQR Glycine betaine GFC28_2228 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GFC28_2229 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GFC28_223 ENOG4105VEQ Cold shock protein GFC28_2230 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GFC28_2231 ENOG4105CPN adenine deaminase GFC28_2232 ENOG410838F Glycosyl transferase family 2 GFC28_2237 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GFC28_2238 ENOG4107BJW polysaccharide deacetylase GFC28_2239 ENOG4107QKR Dehydrogenase GFC28_2241 ENOG4107RUY (E1 component), alpha subunit GFC28_2242 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GFC28_2245 ENOG4105C19 ABC transporter GFC28_2248 ENOG4105WH1 Two component transcriptional regulator luxr family GFC28_2250 ENOG4105C26 Dehydrogenase GFC28_2252 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GFC28_2254 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) GFC28_2255 ENOG4105KGF protein, YerC YecD GFC28_2256 ENOG4108R5T secreted protein GFC28_2258 ENOG4105C12 Phosphoribosylglycinamide synthetase GFC28_226 ENOG4105KVH Transcriptional regulator GFC28_2260 ENOG4105DC1 bifunctional purine biosynthesis protein purh GFC28_2261 ENOG4108V3E phosphoribosylglycinamide formyltransferase GFC28_2262 ENOG4105CXB phosphoribosylaminoimidazole synthetase GFC28_2264 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GFC28_2265 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GFC28_2266 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GFC28_2267 ENOG4105C8V SAICAR synthetase GFC28_2268 ENOG4105C83 adenylosuccinate lyase GFC28_2269 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GFC28_227 ENOG41082BM Transcriptional regulator, arsr family GFC28_2270 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GFC28_2279 ENOG4105C7N Xanthine uracil vitamin C permease GFC28_2280 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GFC28_2283 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GFC28_229 ENOG41090T1 Membrane GFC28_2290 ENOG4105DQ6 Transposase GFC28_2293 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC28_2301 ENOG41066EA baseplate J family protein GFC28_2302 ENOG4105MFU Protein of unknown function (DUF2634) GFC28_2304 ENOG4105X7F GFC28_2305 ENOG4108WZM domain protein GFC28_2306 ENOG4108FKH Transglycosylase SLT domain GFC28_2307 ENOG4105MTC XkdN-like protein GFC28_2308 ENOG4105FR7 XkdM protein, phage-like element PBSX GFC28_2309 ENOG4105PQS phage protein GFC28_2311 ENOG41060SN GFC28_2318 ENOG4106CGH Phage Mu protein F like protein GFC28_2319 ENOG4108MDF Phage Portal Protein GFC28_2320 ENOG4105IG6 Phage terminase, large subunit GFC28_2336 ENOG4108PNI recT protein GFC28_2337 ENOG4108NF7 phage-type endonuclease GFC28_234 ENOG4105CZM Major Facilitator GFC28_235 ENOG4106P55 Transcriptional regulator GFC28_2357 ENOG4105VTR Integrase GFC28_2358 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GFC28_2359 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GFC28_2360 ENOG4108TYN CAAX amino terminal protease family protein GFC28_2362 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GFC28_2363 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GFC28_2364 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GFC28_2365 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GFC28_2366 ENOG4105C5H ABC transporter GFC28_2367 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GFC28_2368 ENOG410801F ribosomal-protein-alanine acetyltransferase GFC28_2369 ENOG41072GX Peptidase M22 Glycoprotease GFC28_2370 ENOG4105K8N protein family UPF0079, ATPase GFC28_2389 ENOG410906U SprT-like GFC28_2392 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GFC28_2394 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GFC28_2395 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GFC28_2396 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GFC28_2398 ENOG4105C1J atp-dependent rna helicase GFC28_24 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GFC28_2400 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GFC28_2401 ENOG4105CPF Cell wall formation (By similarity) GFC28_2403 ENOG4107ZTW SNARE associated Golgi GFC28_2404 ENOG4108ZJ4 polysaccharide deacetylase GFC28_2405 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GFC28_2407 ENOG4105WH1 Two component transcriptional regulator luxr family GFC28_2415 ENOG4108TGC Acyltransferase GFC28_2420 ENOG4105C0X amino acid GFC28_2421 ENOG4105CZN Potassium uptake protein GFC28_2424 ENOG4105E0M Sulfatase GFC28_2425 ENOG4107ZXU DSBA oxidoreductase GFC28_2430 ENOG4105E0A ABC, transporter GFC28_2432 ENOG4105DQ5 transport system permease protein GFC28_2433 ENOG4105EHG Permease protein GFC28_2434 ENOG4105NIV Esterase GFC28_2435 ENOG4108SA1 esterase GFC28_2436 ENOG4107Y03 Nitroreductase GFC28_244 ENOG41086VY Fic/DOC family GFC28_2440 ENOG410874W AraC family transcriptional regulator GFC28_2442 ENOG4105WQT MbtH domain protein GFC28_2443 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_2444 ENOG4105WQI isochorismatase GFC28_2445 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GFC28_2446 ENOG4105E4F Isochorismate synthase GFC28_2447 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GFC28_2448 ENOG4105DWF phosphomethylpyrimidine kinase GFC28_2450 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GFC28_2455 ENOG4105C6X Major Facilitator GFC28_2456 ENOG410874W AraC family transcriptional regulator GFC28_2457 ENOG4108DBC nitroreductase GFC28_2460 ENOG4108ZJ4 polysaccharide deacetylase GFC28_2462 ENOG4105KVH Transcriptional regulator GFC28_2463 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GFC28_2467 ENOG4107YBY Hydrolase GFC28_2471 ENOG4105E6M Sulphatase-modifying factor protein GFC28_2474 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GFC28_2477 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GFC28_2478 ENOG4107U5W ybbr family GFC28_2479 ENOG4105C8B TIGR00159 family GFC28_2480 ENOG4105KXB anti-sigma factor GFC28_2481 ENOG4105EMN RNA polymerase sigma factor GFC28_25 ENOG4105II7 pyrroline-5-carboxylate reductase GFC28_2500 ENOG4108NMV polysaccharide deacetylase GFC28_2503 ENOG4105D1F ATP-binding protein GFC28_2506 ENOG4107TVC Glycosyl transferase, family 2 GFC28_2508 ENOG4107TVC Glycosyl transferase, family 2 GFC28_2512 ENOG4108UJD 30S ribosomal protein S9 GFC28_2513 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GFC28_2514 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GFC28_2515 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GFC28_2516 ENOG4108JJB ABC transporter GFC28_2517 ENOG4108JJB ABC transporter GFC28_2518 ENOG4108ZT0 50S ribosomal protein l17 GFC28_2519 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC28_252 ENOG4108JUB Transcriptional regulator GFC28_2520 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GFC28_2521 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GFC28_2522 ENOG41067V7 50S ribosomal protein L36 GFC28_2523 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GFC28_2525 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GFC28_2526 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GFC28_2527 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GFC28_2528 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GFC28_2529 ENOG4105VPB 50S ribosomal protein L30 GFC28_2530 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GFC28_2531 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GFC28_2532 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GFC28_2533 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GFC28_2534 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GFC28_2535 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GFC28_2536 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GFC28_2537 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GFC28_2538 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GFC28_2539 ENOG41082SA 50s ribosomal protein l29 GFC28_254 ENOG4105C0A alcohol dehydrogenase GFC28_2540 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GFC28_2541 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GFC28_2542 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GFC28_2543 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GFC28_2544 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GFC28_2545 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GFC28_2546 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GFC28_2547 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GFC28_2548 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GFC28_2549 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GFC28_255 ENOG4105G6Z alkaline phosphatase GFC28_2550 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GFC28_2551 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GFC28_2552 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GFC28_2553 ENOG4105XPM ribosomal protein GFC28_2554 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC28_2555 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC28_2556 ENOG4107Y49 methyltransferase GFC28_2557 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GFC28_2558 ENOG4108VZM 50s ribosomal protein L10 GFC28_2560 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GFC28_2561 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GFC28_2562 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GFC28_2563 ENOG410683Z Preprotein translocase SecE subunit GFC28_2564 ENOG4105QIV RNA polymerase GFC28_2565 ENOG4105M0M Tetracycline resistance protein GFC28_2566 ENOG4105C2N RNA methyltransferase TrmH family group 3 GFC28_2568 ENOG4105C8N cysteinyl-tRNA synthetase GFC28_2569 ENOG4105D7W serine acetyltransferase GFC28_2570 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GFC28_2571 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GFC28_2572 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GFC28_2573 ENOG4105CTP PilT protein domain protein GFC28_2574 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GFC28_2576 ENOG41066A3 ATP guanido phosphotransferase GFC28_2577 ENOG4108Z0C Uvrb UvrC protein GFC28_259 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GFC28_26 ENOG41069FQ Metallo-beta-lactamase superfamily GFC28_260 ENOG4108MRH transcriptional regulatory protein GFC28_2600 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GFC28_2602 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GFC28_2603 ENOG4105KRF dihydroneopterin aldolase GFC28_2604 ENOG4105EEI dihydropteroate synthase GFC28_2605 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GFC28_2606 ENOG4105DDQ anthranilate synthase GFC28_2607 ENOG4105CRQ synthase (Component I) GFC28_2608 ENOG4105C6T cysteine synthase GFC28_2609 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GFC28_2610 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GFC28_2611 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GFC28_2612 ENOG4108UGV hypoxanthine phosphoribosyltransferase GFC28_2613 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GFC28_2619 ENOG41060GV RNA binding s1 domain protein GFC28_2622 ENOG4105VYY sporulation protein yabp GFC28_2623 ENOG41082I2 s4 domain protein GFC28_2624 ENOG4108IY2 MazG family GFC28_2626 ENOG4108M14 stage v sporulation protein t GFC28_2627 ENOG4108JA2 transcriptioN-repair coupling factor GFC28_2629 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GFC28_2630 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GFC28_2632 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GFC28_2633 ENOG4105K4W Could be involved in septation (By similarity) GFC28_2634 ENOG4105KME endoribonuclease L-psp GFC28_2635 ENOG4105DFT pur operon repressor GFC28_2636 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GFC28_2638 ENOG4105W42 Veg protein GFC28_2639 ENOG4105XFA sporulation peptidase YabG GFC28_2640 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GFC28_2641 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GFC28_2642 ENOG41069ER domain protein GFC28_2643 ENOG4105F8V Hydrolase, tatD family GFC28_2645 ENOG4105KRN Transcriptional regulator, abrb family GFC28_2646 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GFC28_2647 ENOG41060K3 Methyltransferase GFC28_2648 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) GFC28_2649 ENOG4105MA4 psp1 domain protein GFC28_2650 ENOG4105FA2 dna polymerase iii GFC28_2651 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GFC28_2652 ENOG4105CXN decarboxylase GFC28_2654 ENOG4105DQ6 Transposase GFC28_2655 ENOG4105DQ6 Transposase GFC28_266 ENOG4107R7I amino acid GFC28_2662 ENOG41067KS pro-sigma K processing GFC28_2664 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GFC28_2665 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GFC28_2666 ENOG4105C6E dna polymerase iii GFC28_2667 ENOG4108Z6B deaminase GFC28_2668 ENOG4105VRS hydrolase family 18 GFC28_2670 ENOG4105ZMH deoxynucleoside kinase GFC28_2672 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GFC28_2673 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GFC28_2674 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GFC28_2676 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GFC28_268 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GFC28_2685 ENOG4105CPI Metal Dependent Phosphohydrolase GFC28_2686 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC28_2687 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC28_2688 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GFC28_2689 ENOG410848D S4 domain protein YaaA GFC28_269 ENOG4105C2J ABC transporter GFC28_2690 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GFC28_2691 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GFC28_2692 ENOG4105VG0 50S ribosomal protein l34 GFC28_2693 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GFC28_2694 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GFC28_2696 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GFC28_2697 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GFC28_2698 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GFC28_2699 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) GFC28_27 ENOG4108IXY short-chain dehydrogenase reductase GFC28_270 ENOG4105CNN ABC, transporter GFC28_2700 ENOG4107QJE Chromosome Partitioning Protein GFC28_2701 ENOG4105FA0 parb-like partition protein GFC28_2703 ENOG4108ZDA Sporulation protein YyaC GFC28_2704 ENOG4105D8X mechanosensitive ion channel GFC28_2705 ENOG4105VDK protein, conserved in bacteria GFC28_2706 ENOG4108J2R molybdopterin oxidoreductase GFC28_2707 ENOG4105C3G gtp-binding protein GFC28_2708 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GFC28_2709 ENOG4108UUM single-stranded DNA-binding protein GFC28_271 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GFC28_2710 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GFC28_2711 ENOG4108XMW Membrane GFC28_2712 ENOG4105BZR domain protein GFC28_2713 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GFC28_2714 ENOG4105CDU Replicative dna helicase GFC28_2715 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GFC28_2716 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC28_2717 ENOG4105BZU Histidine kinase GFC28_272 ENOG4105ETE Transcriptional regulator (LacI family GFC28_2720 ENOG4105Q2H domain protein GFC28_2721 ENOG4105C0H protease GFC28_2723 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GFC28_2724 ENOG41067QW Transcriptional regulator GFC28_273 ENOG4105CK5 oxidoreductase GFC28_2730 ENOG4106M28 alanine racemase domain protein GFC28_2731 ENOG4105BZW Glycerate kinase GFC28_2732 ENOG4105BZG amino acid carrier protein GFC28_2736 ENOG4105C32 Amino acid ABC transporter (Permease) GFC28_2737 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GFC28_2738 ENOG4105C0Z ABC transporter GFC28_2739 ENOG4108IV0 ABC, transporter GFC28_2740 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GFC28_2741 ENOG4105E2S oxidase) subunit II GFC28_2742 ENOG4105BZ9 Cytochrome C oxidase, subunit I GFC28_2744 ENOG41060D1 Quinol oxidase GFC28_2746 ENOG4105E5Q amino acid AbC transporter GFC28_2747 ENOG4106PMH Extracellular solute-binding protein family 3 GFC28_2748 ENOG4105CK7 Sodium proline symporter GFC28_2749 ENOG4105DCF alanine dehydrogenase GFC28_2750 ENOG4108K8K Transcriptional regulator GFC28_2752 ENOG41079KZ Major Facilitator Superfamily GFC28_2753 ENOG4108RJ9 Glycosyl transferase, family 2 GFC28_2754 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GFC28_2757 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GFC28_2758 ENOG4105CG3 alpha amylase, catalytic region GFC28_276 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GFC28_2762 ENOG4108VKI Cell wall hydrolase GFC28_2763 ENOG4107JTW chlorite dismutase GFC28_2764 ENOG4108IJ2 phosphate acetyltransferase GFC28_2765 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GFC28_2766 ENOG4108VCI transcription factor, rsfa family GFC28_2767 ENOG4105QAT UPF0741 protein GFC28_2768 ENOG4105DCI Phosphohydrolase GFC28_277 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GFC28_2771 ENOG4105C7N Xanthine uracil vitamin C permease GFC28_2772 ENOG41069HH 4-oxalocrotonate tautomerase GFC28_2773 ENOG4108Z4T Peptidase M50 GFC28_2774 ENOG4108XFG YwhD family GFC28_2775 ENOG4105BZ4 penicillin-binding protein GFC28_2776 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GFC28_2777 ENOG4105CYW agmatinase GFC28_2778 ENOG410684U Domain of unknown function (DUF1934) GFC28_2779 ENOG4105C75 arginyL-tRNA synthetase GFC28_278 ENOG4105D2N Aldolase GFC28_2782 ENOG4105DF6 Fe-S oxidoreductase GFC28_2784 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC28_2785 ENOG4105C1G acyl-Coa dehydrogenase GFC28_2786 ENOG4105C1G acyl-Coa dehydrogenase GFC28_2788 ENOG4105D5P Methylmalonyl-coA mutase GFC28_279 ENOG4105DH8 myo-inositol catabolism GFC28_2790 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GFC28_2792 ENOG410812K response regulator receiver protein GFC28_2794 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GFC28_2795 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GFC28_2796 ENOG4105CBT Fructose-1,6-bisphosphatase GFC28_2797 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GFC28_2798 ENOG41082DI 50s ribosomal protein l31 GFC28_2799 ENOG4107104 thymidine kinase GFC28_2803 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GFC28_2804 ENOG4105C26 Dehydrogenase GFC28_2806 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GFC28_2807 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GFC28_2808 ENOG4108ZXQ stage ii sporulation protein r GFC28_2809 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GFC28_2810 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GFC28_2812 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_2813 ENOG4108YZG isomerase GFC28_2814 ENOG4108UIC UPF0340 protein GFC28_2815 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GFC28_2816 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GFC28_2819 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GFC28_2820 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GFC28_2821 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GFC28_2822 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GFC28_2823 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GFC28_2824 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GFC28_2825 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GFC28_2826 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GFC28_2827 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GFC28_2828 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC28_2829 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GFC28_2830 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC28_2831 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GFC28_2834 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC28_2835 ENOG4105D65 subunit l GFC28_2836 ENOG4105C8S subunit m GFC28_2837 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC28_2838 ENOG4106778 Protein of unknown function (DUF1146) GFC28_2840 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GFC28_2842 ENOG4105FRN stage II sporulation protein GFC28_2844 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GFC28_2845 ENOG4105DFF Rod shape-determining protein mreb GFC28_2847 ENOG4105CGA flagellar basal-body rod protein FlgG GFC28_2849 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GFC28_285 ENOG4107QRT dEAD DEAH box helicase GFC28_2852 ENOG410667J hydrolase GFC28_2853 ENOG4105ETE Transcriptional regulator (LacI family GFC28_2854 ENOG4105CKB glycosidase GFC28_2857 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GFC28_2860 ENOG4105DG6 mannose-6-phosphate isomerase GFC28_2861 ENOG4105ETE Transcriptional regulator (LacI family GFC28_2862 ENOG4108RVA ribokinase GFC28_2863 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GFC28_2864 ENOG4105C2J ABC transporter GFC28_2865 ENOG4105CNN ABC, transporter GFC28_2866 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GFC28_2868 ENOG4108M8H domain protein GFC28_2870 ENOG4105DG6 mannose-6-phosphate isomerase GFC28_2871 ENOG4105VZJ PTS System GFC28_2872 ENOG4105VCP PTS System GFC28_2873 ENOG4105CK1 PTS System GFC28_2874 ENOG4105CS2 ec 3.2.1.21 GFC28_2875 ENOG4108TZY GntR Family Transcriptional Regulator GFC28_2877 ENOG4105EE0 oxidoreductase GFC28_2878 ENOG4105EVU fructokinase GFC28_2880 ENOG41067SE Tetr family transcriptional regulator GFC28_2881 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC28_2882 ENOG4105W1N transcriptional regulator GFC28_2886 ENOG4105C26 Dehydrogenase GFC28_2891 ENOG4105CFH Aspartokinase GFC28_2895 ENOG4105Z8H single-stranded DNA-binding protein GFC28_2898 ENOG4105C0D helicase GFC28_2902 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GFC28_2904 ENOG4105C6Y Udp-glucose 6-dehydrogenase GFC28_2907 ENOG4105CJR Integral membrane protein (MviN GFC28_2914 ENOG4107TT5 NLP P60 protein GFC28_2923 ENOG4105HIR S-layer domain protein GFC28_2925 ENOG4108TDH Cell wall binding repeat 2-containing protein GFC28_2927 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC28_2935 ENOG4106A2Z transcriptional regulator antitoxin, MazE GFC28_294 ENOG4107XVH Transcriptional regulator GFC28_2941 ENOG4106I4J membrane GFC28_2942 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GFC28_2945 ENOG4105KRI phosphocarrier protein (HPr GFC28_2948 ENOG4105CMT Dihydroxyacetone kinase GFC28_2949 ENOG4108JUB Transcriptional regulator GFC28_295 ENOG4105XRQ Xanthine dehydrogenase accessory factor GFC28_2950 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GFC28_2951 ENOG4107V2S Transcriptional regulator GFC28_2955 ENOG4105CJZ response regulator GFC28_2956 ENOG4105EWM Histidine kinase GFC28_2957 ENOG4105C19 ABC transporter GFC28_2959 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GFC28_2964 ENOG4105DF9 Lipoate-protein, ligase GFC28_2969 ENOG4105C4M (Ubiquinol oxidase) subunit I GFC28_2970 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GFC28_2971 ENOG4108JJ9 ABC, transporter GFC28_2972 ENOG4108JJ8 (ABC) transporter GFC28_2979 ENOG4105RYY domain protein GFC28_2981 ENOG4107BJW polysaccharide deacetylase GFC28_2983 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GFC28_2986 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GFC28_2989 ENOG4105CJR Integral membrane protein (MviN GFC28_2990 ENOG4105ESV Glycosyl transferase, family 4 GFC28_2991 ENOG4108KGH TRANSCRIPTIONal GFC28_2992 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GFC28_2993 ENOG4105BZU Histidine kinase GFC28_2994 ENOG4105WH1 Two component transcriptional regulator luxr family GFC28_2997 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GFC28_3 ENOG4108HW3 (ABC) transporter GFC28_3000 ENOG4105XVJ Protein of unknown function (DUF327) GFC28_3004 ENOG4105E1Q flagellar hook-associated protein GFC28_3005 ENOG4105DTJ flagellar hook-associated protein GFC28_3006 ENOG4105MKD GFC28_3007 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GFC28_3008 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GFC28_3009 ENOG4105I03 Flagellin GFC28_3014 ENOG4108IAJ Nad-dependent epimerase dehydratase GFC28_3015 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GFC28_3016 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase GFC28_3017 ENOG4105D2T synthase GFC28_302 ENOG4105E39 Enoyl-CoA hydratase GFC28_3020 ENOG4105F0R Cytidylyltransferase GFC28_3021 ENOG4105I03 Flagellin GFC28_3023 ENOG4107RT6 flagellar hook-associated GFC28_3024 ENOG4105MQ3 flagellar protein FliS GFC28_303 ENOG4105CSH Transporter GFC28_3030 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GFC28_3031 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GFC28_3034 ENOG4105CAK Cell division ATP-binding protein ftsE GFC28_3035 ENOG4105CRP Part of the ABC transporter FtsEX involved in GFC28_3037 ENOG4105D3R alkyl hydroperoxide reductase GFC28_3038 ENOG4108JU3 Alkyl hydroperoxide reductase GFC28_3041 ENOG4105C37 (CBS) domain GFC28_3044 ENOG4105KTU Transcriptional regulator, arsr family GFC28_3045 ENOG4105PGM cation diffusion facilitator family transporter GFC28_3046 ENOG4105CN1 protease GFC28_3055 ENOG41062GF Polar chromosome segregation protein GFC28_3058 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GFC28_3059 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GFC28_3061 ENOG41086DT Membrane protein of unknown function GFC28_3062 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GFC28_3063 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GFC28_3064 ENOG4105HKU nucleoside recognition domain-containing protein GFC28_3065 ENOG4107XGZ Hydrolase GFC28_3066 ENOG4108S4C acetyltransferase GFC28_3068 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GFC28_3069 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GFC28_3070 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GFC28_3071 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GFC28_3072 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GFC28_3073 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GFC28_3074 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GFC28_3075 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GFC28_3077 ENOG4105C3M thioredoxin reductase GFC28_3078 ENOG4108Z4K mutator MutT protein GFC28_3079 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GFC28_3080 ENOG4105CHW UPF0052 protein GFC28_3081 ENOG4105CIE May be required for sporulation (By similarity) GFC28_3082 ENOG4105KRI phosphocarrier protein (HPr GFC28_3083 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GFC28_3086 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC28_3090 ENOG4105BZA Phosphoglycerate kinase GFC28_3091 ENOG4105CP7 Triose-phosphate isomerase GFC28_3093 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GFC28_3095 ENOG4105XZU Preprotein translocase, subunit SecG GFC28_3097 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GFC28_3098 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GFC28_310 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GFC28_3109 ENOG4105D5G Transposase GFC28_311 ENOG4105BZF Glycosyl transferase (Group 1 GFC28_3115 ENOG4108RDQ ABC transporter GFC28_3121 ENOG4105C3M thioredoxin reductase GFC28_3124 ENOG4105BZU Histidine kinase GFC28_3125 ENOG4105BZ1 (ABC) transporter GFC28_3126 ENOG4105BZ1 (ABC) transporter GFC28_3127 ENOG4107Y03 Nitroreductase GFC28_3137 ENOG4105CHR reductase GFC28_314 ENOG4105DQ6 Transposase GFC28_3141 ENOG4105K64 Glycosyl transferase, family 2 GFC28_3143 ENOG4107EF8 Glycosyl transferase (Group 1 GFC28_3146 ENOG4105C4B ABC transporter, permease GFC28_315 ENOG4108IUW ABC transporter GFC28_3155 ENOG4105CHU acetyl-coa acetyltransferase GFC28_3156 ENOG4105C1G acyl-Coa dehydrogenase GFC28_3157 ENOG41080E8 Transcriptional regulator, Spx MgsR family GFC28_3158 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GFC28_3163 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GFC28_3164 ENOG4108UMI ABC transporter, permease GFC28_3165 ENOG4105D01 (LipO)protein GFC28_3167 ENOG4105C3K feS assembly ATPase SufC GFC28_3168 ENOG4105JRK feS assembly protein SufD GFC28_3170 ENOG4108UNV SUF system FeS assembly protein, NifU family GFC28_3171 ENOG4105DIW FeS assembly protein SUFB GFC28_3172 ENOG4105I3N Conserved Protein GFC28_3174 ENOG4107R8B 5'-nucleotidase GFC28_3175 ENOG4105KZD Domain of unknown function (DUF1805) GFC28_3176 ENOG4108YTE sporulation protein YunB GFC28_3177 ENOG4105FAA peptidase M23 GFC28_3178 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GFC28_318 ENOG4108RAV Conserved protein GFC28_3180 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GFC28_3181 ENOG4105MMD transcriptional regulator GFC28_3186 ENOG4105D4U had-superfamily hydrolase, subfamily iia GFC28_3187 ENOG4108W5N phosphatidylglycerophosphatase a GFC28_3189 ENOG4105C5I Dehydrogenase GFC28_3191 ENOG4105D5G Transposase GFC28_3198 ENOG4106QJ6 Integrase catalytic subunit GFC28_32 ENOG4106HZJ GFC28_320 ENOG4105D94 Major Facilitator Superfamily GFC28_3204 ENOG4105D5G Transposase GFC28_3206 ENOG4105D6E homoserine dehydrogenase GFC28_3207 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GFC28_3208 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GFC28_3209 ENOG41083MR nifu domain-containing protein GFC28_321 ENOG4105D01 (LipO)protein GFC28_3213 ENOG4105ZKE UPF0349 protein GFC28_3215 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GFC28_3216 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GFC28_3217 ENOG4105CAY ferredoxin--nadp reductase GFC28_3218 ENOG4105CEP NADH dehydrogenase GFC28_322 ENOG4108UMI ABC transporter, permease GFC28_3222 ENOG41069ER domain protein GFC28_3223 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GFC28_3225 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GFC28_3226 ENOG4107GRR phosphate transport regulator GFC28_3227 ENOG4105CJ3 phosphate transporter GFC28_323 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GFC28_3234 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GFC28_3236 ENOG4105C87 Aminotransferase class I and II GFC28_3238 ENOG4108ZB6 transcriptional regulator AsnC family GFC28_3239 ENOG4105CHM Aminotransferase GFC28_324 ENOG4105WDJ 50S ribosomal protein L33 GFC28_3242 ENOG4105WG9 Conserved Protein GFC28_3243 ENOG4107QW4 alcohol dehydrogenase GFC28_3249 ENOG4107PBV potassium channel GFC28_325 ENOG4105NRA 50s ribosomal protein l31 type b GFC28_3251 ENOG4106GRI small acid-soluble spore protein H GFC28_3252 ENOG41060AI SEC-C motif GFC28_3254 ENOG4107TCE N-acetyltransferase GFC28_3256 ENOG4105D4Y metalloprotease GFC28_3257 ENOG4105CPF Cell wall formation (By similarity) GFC28_3258 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_3259 ENOG4105KT7 mgtC SapB transporter GFC28_327 ENOG4105E39 Enoyl-CoA hydratase GFC28_3280 ENOG4105PGM cation diffusion facilitator family transporter GFC28_3284 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GFC28_3289 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GFC28_3290 ENOG4105E4F Isochorismate synthase GFC28_3291 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GFC28_3292 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GFC28_3293 ENOG4108IPT Naphthoate synthase GFC28_3294 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_3303 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GFC28_3304 ENOG4108RMU ferritin dps family protein GFC28_3305 ENOG4105XSJ toxin secretion phage lysis holin GFC28_3307 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GFC28_3309 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GFC28_3311 ENOG4105D2X ABC transporter substrate-binding protein GFC28_3314 ENOG4108TWJ NADH dehydrogenase subunit 5 GFC28_3315 ENOG4105EVH UPF0753 protein GFC28_3316 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GFC28_3317 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GFC28_3319 ENOG4105CAQ asparagine synthetase GFC28_332 ENOG4105VG1 fes assembly suf system protein GFC28_3320 ENOG4108Z0R Transferase GFC28_3321 ENOG4105E8V Alpha Beta Hydrolase Fold protein GFC28_3324 ENOG4105N5T Radical SAM Protein GFC28_3327 ENOG410605W Major Facilitator GFC28_3329 ENOG4105C8T Leucyl-tRNA synthetase GFC28_3330 ENOG41085GJ domain protein GFC28_3335 ENOG4105CBX hi0933 family GFC28_3339 ENOG4105YW5 deoR family transcriptional regulator GFC28_3340 ENOG4107QSE Dipeptidase GFC28_3344 ENOG41067MG lrgb family GFC28_3346 ENOG4108IUM Glycogen debranching enzyme GFC28_3348 ENOG4108V15 phosphotransferase enzyme family GFC28_3349 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GFC28_335 ENOG4105E39 Enoyl-CoA hydratase GFC28_3350 ENOG4105C8F Beta-lactamase domain protein GFC28_3353 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GFC28_3355 ENOG4108NKM UPF0354 protein GFC28_3356 ENOG4108VDD TRNA binding domain protein GFC28_3358 ENOG4105DAP Nicotinate phosphoribosyltransferase GFC28_3359 ENOG4105DFU Cell wall formation (By similarity) GFC28_3360 ENOG4105C88 aminopeptidase GFC28_3364 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GFC28_3365 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GFC28_3366 ENOG4105ETE Transcriptional regulator (LacI family GFC28_3367 ENOG4105DGU Histone deacetylase GFC28_3368 ENOG4105W87 Cbs domain GFC28_3369 ENOG4105F1V Acetoin utilization protein GFC28_3373 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GFC28_3374 ENOG4105BZU Histidine kinase GFC28_3376 ENOG4108W76 histidinol phosphate phosphatase hisj family GFC28_3377 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) GFC28_3379 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GFC28_338 ENOG4105CPN adenine deaminase GFC28_3381 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GFC28_3382 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GFC28_3383 ENOG4105D07 Signal peptide peptidase, SppA GFC28_3384 ENOG4105VK3 rdd domain containing protein GFC28_3386 ENOG4105KBJ sporulation protein ytfj GFC28_3387 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GFC28_3389 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GFC28_339 ENOG4105EF1 ribulokinase GFC28_3390 ENOG4105EPU Molybdenum cofactor synthesis domain protein GFC28_3393 ENOG4105CDH Citrulline--aspartate ligase GFC28_3394 ENOG4105CH7 arginosuccinase GFC28_3395 ENOG4107YZX Universal stress protein GFC28_3399 ENOG4105DC7 peptidase M24 GFC28_340 ENOG4105DJV ribulose-phosphate 3-epimerase GFC28_3400 ENOG4105E8R UPF0173 metal-dependent hydrolase GFC28_3403 ENOG4105SFS phosphoesterase RecJ domain protein GFC28_3405 ENOG4105VV2 GFC28_3406 ENOG4105C0B DNA polymerase III (alpha subunit) GFC28_3407 ENOG4105C6K Malic enzyme GFC28_3408 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GFC28_3409 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GFC28_341 ENOG4108RVA ribokinase GFC28_3410 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GFC28_3411 ENOG4105CTQ phosphohexokinase GFC28_3414 ENOG4108REF Sporulation integral membrane protein ytvi GFC28_3415 ENOG4108VMM UPF0756 membrane protein GFC28_3416 ENOG4105BZN citrate synthase GFC28_3417 ENOG4108HMX isocitrate dehydrogenase (NADP) GFC28_3418 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GFC28_342 ENOG4105C2J ABC transporter GFC28_3420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GFC28_3421 ENOG4105BZU Histidine kinase GFC28_3423 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GFC28_3424 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GFC28_3425 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GFC28_3426 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GFC28_3428 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GFC28_343 ENOG4105CNN ABC, transporter GFC28_3431 ENOG4108TDW sporulation protein YtxC GFC28_3432 ENOG4105C22 threonyL-tRNA synthetase GFC28_3434 ENOG4105VJV 50s ribosomal protein L35 GFC28_3435 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GFC28_3438 ENOG4105CN9 Peptidase m42 family protein GFC28_3439 ENOG4108D32 Methyltransferase GFC28_3441 ENOG41067MF small acid-soluble spore protein GFC28_3442 ENOG4108RWN rrna methyltransferase GFC28_3444 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GFC28_3445 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GFC28_3446 ENOG4105CJ1 ABC, transporter GFC28_3447 ENOG4108TU7 Inherit from COG: (ABC) transporter GFC28_3449 ENOG4105EYF MMPL domain protein GFC28_345 ENOG4105D4B ABC, transporter GFC28_3450 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GFC28_3451 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GFC28_3453 ENOG4105DCG PHP domain protein GFC28_3454 ENOG4105C98 muts2 protein GFC28_3456 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_3457 ENOG4107Z3H Transcriptional regulator, TetR family GFC28_3458 ENOG41060WC Enoyl-CoA hydratase GFC28_3459 ENOG4105BZJ Electron transfer flavoprotein GFC28_3460 ENOG4105C10 Electron transfer flavoprotein GFC28_3461 ENOG4105K63 Thioredoxin GFC28_3462 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GFC28_3463 ENOG4105C1B dTDP-glucose 4-6-dehydratase GFC28_3465 ENOG4105C3Q Glycosyl transferase, family 2 GFC28_3469 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GFC28_347 ENOG4105DET Rhamnulokinase GFC28_3473 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GFC28_3475 ENOG4105E33 succinate dehydrogenase GFC28_3476 ENOG4105PFC Transcriptional regulator GFC28_3477 ENOG41067TZ transcriptional regulator, MarR family GFC28_3478 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GFC28_3479 ENOG4108XJQ germination protein GFC28_348 ENOG4105DKG l-rhamnose isomerase GFC28_3480 ENOG4108FK2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GFC28_3481 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GFC28_3482 ENOG4105M59 Phosphodiesterase, mj0936 family GFC28_3484 ENOG4105CM2 brancheD-chain amino acid aminotransferase GFC28_3485 ENOG4105C7K acetolactate synthase GFC28_3486 ENOG4108ZP8 Acetolactate synthase small subunit GFC28_3487 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GFC28_3488 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GFC28_3489 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GFC28_349 ENOG4105E98 transcriptional regulator DeoR family GFC28_3490 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GFC28_3491 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GFC28_3493 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GFC28_3494 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GFC28_3495 ENOG4108IUQ atp-dependent protease GFC28_3496 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GFC28_3497 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GFC28_3499 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GFC28_35 ENOG4105CPC Aldo Keto reductase GFC28_3501 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GFC28_3503 ENOG4105D52 delta-aminolevulinic acid dehydratase GFC28_3504 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GFC28_3505 ENOG41068KH stage VI sporulation protein D GFC28_3505 ENOG41068KH stage VI sporulation protein D GFC28_3508 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GFC28_3509 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GFC28_351 ENOG4108UT2 hemolysin iii GFC28_3518 ENOG4107QHF type ii secretion system protein e GFC28_3519 ENOG4105CZX twitching motility protein GFC28_3522 ENOG4106A3R peptidase GFC28_3528 ENOG4108Z03 MAF-like protein GFC28_3529 ENOG4105W5Q DNA repair protein (RadC GFC28_353 ENOG41088SP formiminoglutamate hydrolase GFC28_3530 ENOG4105DFF Rod shape-determining protein mreb GFC28_3531 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GFC28_3532 ENOG4105YHC Rod shape-determining protein MreD GFC28_3533 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GFC28_3534 ENOG4107QMS site-determining protein GFC28_3537 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GFC28_3538 ENOG4105X36 (ribosomal) protein GFC28_3539 ENOG4105K46 50S ribosomal protein l27 GFC28_3541 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GFC28_3542 ENOG41090I5 UPF0735 ACT domain-containing protein GFC28_3543 ENOG4105CQC Prephenate dehydratase GFC28_3548 ENOG4105V75 Transcriptional regulator GFC28_3549 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GFC28_355 ENOG4105T16 Transcriptional regulator (AraC family) GFC28_3552 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GFC28_3555 ENOG4108IYU L-aspartate oxidase GFC28_3556 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GFC28_3557 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GFC28_3558 ENOG4106678 morphogenetic protein associated with SpoVID GFC28_356 ENOG4105CGP Urocanate hydratase GFC28_3560 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GFC28_3562 ENOG4105CDY transcriptional regulatory protein GFC28_3565 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GFC28_3566 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GFC28_3567 ENOG41061AI Protein of unknown function (DUF2905) GFC28_3568 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GFC28_3569 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GFC28_357 ENOG4105CI2 imidazolone-5-propionate hydrolase GFC28_3570 ENOG4105VIE preprotein translocase, subunit YajC GFC28_3571 ENOG4105NAP GFC28_3572 ENOG4105CKP Polysaccharide Biosynthesis Protein GFC28_3574 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GFC28_3575 ENOG41076HS cation diffusion facilitator family transporter GFC28_3576 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GFC28_3577 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GFC28_3578 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GFC28_3579 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GFC28_358 ENOG4105DWD nucleoside recognition domain protein GFC28_3580 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC28_3582 ENOG4105CUT histidyl-tRNA synthetase GFC28_3583 ENOG4105C9M aspartyl-trna synthetase GFC28_3584 ENOG4105CUZ uba thif-type nad fad binding protein GFC28_3585 ENOG41067SE Tetr family transcriptional regulator GFC28_3586 ENOG4105D1H recombination factor protein RarA GFC28_3589 ENOG4105C3J Cysteine desulfurase GFC28_359 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GFC28_3590 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GFC28_3592 ENOG4105C7H Helicase, RecD TraA family GFC28_3593 ENOG41060CR GFC28_3595 ENOG4105C02 permease GFC28_3596 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GFC28_3597 ENOG4105VBH UPF0297 protein GFC28_3598 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GFC28_3599 ENOG4105VPH UPF0473 protein GFC28_36 ENOG4108YZ4 nudix hydrolase GFC28_3600 ENOG4105HHA aminodeoxychorismate lyase GFC28_3601 ENOG4108VQJ O-methyltransferase GFC28_3602 ENOG4105XYU peptidase (U32 family) GFC28_3603 ENOG4105CFP Peptidase U32 GFC28_3604 ENOG4105DBI uridine monophosphokinase GFC28_3605 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GFC28_3606 ENOG4107XRG penicillin-binding protein GFC28_3609 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GFC28_3610 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GFC28_3612 ENOG4105C28 cystathionine GFC28_3614 ENOG4105G9B Transcriptional regulator GFC28_3615 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC28_3616 ENOG4105E39 Enoyl-CoA hydratase GFC28_3617 ENOG4105D2S major facilitator superfamily GFC28_3619 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_3620 ENOG4105CHU acetyl-coa acetyltransferase GFC28_3625 ENOG4105ERH Fumarylacetoacetate hydrolase GFC28_3629 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC28_363 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GFC28_3631 ENOG4107T5V SNARE associated Golgi GFC28_3633 ENOG4108REF Sporulation integral membrane protein ytvi GFC28_3634 ENOG4105ER2 Ompa motb domain protein GFC28_3635 ENOG4105E14 MotA TolQ exbB proton channel GFC28_3636 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GFC28_3637 ENOG4105DJ4 phosphatidylserine decarboxylase GFC28_3639 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GFC28_3640 ENOG4105CQW ribosome biogenesis GTPase YqeH GFC28_3641 ENOG4105E2X shikimate dehydrogenase GFC28_3642 ENOG410812S Rna-binding protein GFC28_3643 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GFC28_3644 ENOG4108WF2 Metal Dependent Phosphohydrolase GFC28_3646 ENOG4105DXX methyltransferase GFC28_3648 ENOG4105KQC Competence protein GFC28_3649 ENOG4108UK2 deaminase GFC28_365 ENOG4105DRR Transcriptional regulator, GntR family GFC28_3650 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GFC28_3652 ENOG4105TQK DNA polymerase iii, delta' subunit GFC28_3653 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GFC28_3654 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) GFC28_3655 ENOG4108ZRV stage ii sporulation protein p GFC28_3657 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GFC28_3658 ENOG4105CSA Coproporphyrinogen iii oxidase GFC28_3659 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GFC28_366 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GFC28_3660 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GFC28_3661 ENOG4105CFG Acts as a chaperone (By similarity) GFC28_3662 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GFC28_3663 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GFC28_3664 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GFC28_3665 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GFC28_3666 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GFC28_3668 ENOG4105VCC 30S ribosomal protein S21 GFC28_3669 ENOG4105KTH gatB Yqey GFC28_367 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GFC28_3670 ENOG41068P3 sporulation protein YqfC GFC28_3672 ENOG4105C9A Phoh family GFC28_3673 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GFC28_3674 ENOG4107YR5 Diacylglycerol kinase GFC28_3675 ENOG4105KG3 cytidine deaminase GFC28_3676 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GFC28_3678 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GFC28_368 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GFC28_3680 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GFC28_3682 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 GFC28_3684 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC28_3688 ENOG4105EGD dinuclear metal center protein, YbgI family GFC28_3689 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GFC28_3692 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GFC28_3694 ENOG4105FDK ABC transporter GFC28_3695 ENOG4105FAV ABC, transporter GFC28_3696 ENOG4108U5J '-nucleotidase GFC28_3697 ENOG4105N80 Ferric uptake regulator, Fur family GFC28_3698 ENOG41063Y9 GFC28_3699 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GFC28_370 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GFC28_3701 ENOG4105CVA phosphate GFC28_3702 ENOG4105C8U phosphate abc transporter GFC28_3703 ENOG4105E2Z phosphate ABC transporter (Permease GFC28_3704 ENOG4105EEM helicase GFC28_3706 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_3709 ENOG4107RF6 penicillin-binding protein GFC28_371 ENOG4105C28 cystathionine GFC28_3710 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GFC28_3711 ENOG4108UTW Plays a role in the regulation of phosphate uptake GFC28_3715 ENOG4105WDJ 50S ribosomal protein L33 GFC28_3716 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GFC28_372 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GFC28_3720 ENOG4107ZXI Rhomboid family GFC28_3726 ENOG4105E0M Sulfatase GFC28_3731 ENOG4105C5X domain protein GFC28_3737 ENOG4106855 Competence protein GFC28_3745 ENOG4105C0D helicase GFC28_3746 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GFC28_3747 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GFC28_3749 ENOG4105WZW rhodanese family GFC28_3750 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GFC28_3755 ENOG4105VRS hydrolase family 18 GFC28_3755 ENOG4105VRS hydrolase family 18 GFC28_3757 ENOG4105KST dependent repressor GFC28_3760 ENOG4105CBJ Metal-dependent enzyme GFC28_3762 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GFC28_3763 ENOG4105DC7 peptidase M24 GFC28_3764 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GFC28_3766 ENOG4105CD2 stage iii sporulation protein aa GFC28_3767 ENOG4105KR5 Stage iii sporulation protein GFC28_3768 ENOG4108CQH stage III sporulation protein AC GFC28_3769 ENOG4105KQ4 Stage iii sporulation protein ad GFC28_3771 ENOG410644B Stage III sporulation protein af GFC28_3775 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GFC28_3776 ENOG4108ZSR alkaline shock protein GFC28_3777 ENOG4105M7K Involved in the transcription termination process (By similarity) GFC28_3778 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GFC28_3779 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GFC28_378 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GFC28_3780 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GFC28_3782 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GFC28_3783 ENOG4105DX0 Hemolysin A GFC28_3784 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GFC28_3785 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GFC28_3786 ENOG4105S1Z Stage IV sporulation protein B GFC28_3789 ENOG4105C3M thioredoxin reductase GFC28_3791 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GFC28_3792 ENOG4106CCJ Protein of unknown function (DUF2627) GFC28_3793 ENOG4108JUB Transcriptional regulator GFC28_3796 ENOG4105CKM Branched-chain carboxylic acid kinase GFC28_3799 ENOG4105CPP Dehydrogenase, E1 component GFC28_38 ENOG4105MZ9 stage II sporulation protein m GFC28_380 ENOG4105CPQ Dehydrogenase GFC28_3800 ENOG4105C7S Dehydrogenase GFC28_3804 ENOG4105CMN Methylmalonyl-coA mutase GFC28_3805 ENOG4105D5P Methylmalonyl-coA mutase GFC28_3806 ENOG4105DJT lAO AO transport system ATPase GFC28_3807 ENOG41067QW Transcriptional regulator GFC28_381 ENOG4105CPQ Dehydrogenase GFC28_385 ENOG4105DD7 kinase (PfkB family GFC28_386 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GFC28_39 ENOG4105I3K Ferric uptake regulator, Fur family GFC28_391 ENOG4105EWU Squalene--hopene cyclase GFC28_392 ENOG4107QM2 Aldo Keto reductase GFC28_394 ENOG4105ETD TRANSCRIPTIONal GFC28_397 ENOG4108RE7 deoxyribonuclease GFC28_398 ENOG4105H67 Protein of unknown function (DUF421) GFC28_399 ENOG4105C01 Dihydroxy-acid dehydratase GFC28_4 ENOG4105E5Q amino acid AbC transporter GFC28_401 ENOG4105J7I hydrolase GFC28_405 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_406 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GFC28_407 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GFC28_408 ENOG4105C28 cystathionine GFC28_41 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC28_410 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GFC28_411 ENOG4105DZS Phenylacetate-CoA ligase GFC28_412 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GFC28_415 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GFC28_417 ENOG4105E39 Enoyl-CoA hydratase GFC28_418 ENOG4105CGU Enoyl-CoA hydratase GFC28_419 ENOG4105C26 Dehydrogenase GFC28_420 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC28_421 ENOG4105CHU acetyl-coa acetyltransferase GFC28_422 ENOG4105E39 Enoyl-CoA hydratase GFC28_423 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein GFC28_424 ENOG4108Z0R Transferase GFC28_425 ENOG4105EA8 2-Nitropropane dioxygenase GFC28_429 ENOG4105CPP Dehydrogenase, E1 component GFC28_430 ENOG4105C7S Dehydrogenase GFC28_437 ENOG4105CDW Resistance protein GFC28_445 ENOG4108MES Periplasmic binding protein GFC28_446 ENOG4105DQ5 transport system permease protein GFC28_447 ENOG4108IHU transport system permease protein GFC28_448 ENOG4105E0A ABC, transporter GFC28_450 ENOG4105BZU Histidine kinase GFC28_451 ENOG4105CVJ phosphoglycerate mutase GFC28_452 ENOG4105CE1 Ferrous iron transport protein b GFC28_453 ENOG4105CE1 Ferrous iron transport protein b GFC28_454 ENOG4105CE1 Ferrous iron transport protein b GFC28_455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GFC28_456 ENOG4105NAE bifunctional deaminase-reductase domain protein GFC28_457 ENOG4105NAE bifunctional deaminase-reductase domain protein GFC28_459 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GFC28_46 ENOG4105DZ1 carboxypeptidase GFC28_461 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_462 ENOG4105CSU acyl-Coa dehydrogenase GFC28_464 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GFC28_468 ENOG4105RHY Pfam:UPF0157 GFC28_47 ENOG41082AN stage II sporulation protein GFC28_472 ENOG4105RHY Pfam:UPF0157 GFC28_475 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GFC28_478 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GFC28_479 ENOG4105P4J Allophanate hydrolase, subunit 1 GFC28_48 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GFC28_481 ENOG4105E7W lamb ycsf family protein GFC28_482 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GFC28_483 ENOG4108HIZ formate dehydrogenase alpha subunit GFC28_487 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GFC28_488 ENOG4105DWF phosphomethylpyrimidine kinase GFC28_489 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GFC28_49 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC28_490 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GFC28_491 ENOG4108IQI permease GFC28_492 ENOG4105DUX Transporter GFC28_493 ENOG4107Y9E nuclease GFC28_494 ENOG4105BZU Histidine kinase GFC28_496 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC28_497 ENOG4105BZU Histidine kinase GFC28_498 ENOG4105C6T cysteine synthase GFC28_499 ENOG4108I5C dEAD DEAH box helicase GFC28_5 ENOG4105CDA abc transporter atp-binding protein GFC28_500 ENOG4107X2U Inherit from COG: Exonuclease-like protein GFC28_503 ENOG4108UKS UPF0398 protein GFC28_507 ENOG4108UKS UPF0398 protein GFC28_508 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) GFC28_509 ENOG4105BZU Histidine kinase GFC28_510 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GFC28_515 ENOG4108AEY RNA polymerase sigma factor GFC28_52 ENOG41090VF Stage v sporulation protein ac GFC28_522 ENOG4105DQ6 Transposase GFC28_523 ENOG4106DF4 Sigma-70, region 4 GFC28_529 ENOG4105DVT helicase GFC28_53 ENOG4105CZ3 stage V sporulation protein ad GFC28_530 ENOG4105CTD carboxy-peptidase GFC28_531 ENOG4105CNA YD repeat protein GFC28_55 ENOG4105G6R Stage v sporulation protein ae GFC28_551 ENOG4107RQ2 Cytochrome c oxidase, subunit I GFC28_552 ENOG4105NAA Cytochrome C oxidase, subunit II GFC28_554 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GFC28_555 ENOG4105C2W permease GFC28_556 ENOG4105CDY transcriptional regulatory protein GFC28_557 ENOG41065KQ synthase GFC28_559 ENOG410890F Dynamin family GFC28_562 ENOG4105KHC sulfurtransferase GFC28_563 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC28_565 ENOG41075ZD Small, acid-soluble spore protein N GFC28_566 ENOG41067CD Small, acid-soluble spore protein Tlp GFC28_568 ENOG4105MI2 GFC28_569 ENOG4105KA0 thioesterase Superfamily protein GFC28_570 ENOG4105W8X HesB YadR YfhF-family protein GFC28_574 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GFC28_575 ENOG4105C3M thioredoxin reductase GFC28_576 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GFC28_579 ENOG4107S4Y M20 DapE family protein YgeY GFC28_58 ENOG4105PTM secreted protein GFC28_580 ENOG4108TSC N-acetyltransferase GFC28_581 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GFC28_583 ENOG4105VSD UPF0346 protein GFC28_587 ENOG4105G0J serine threonine protein kinase GFC28_588 ENOG4108N23 SpoOM-related protein GFC28_589 ENOG4106Z5R GFC28_59 ENOG4107ZE5 PPIases accelerate the folding of proteins GFC28_594 ENOG4108VXD carboxy-peptidase GFC28_598 ENOG4105D7N magnesium and cobalt transport protein CorA GFC28_599 ENOG4105FR1 rard protein GFC28_6 ENOG4108QEG Membrane GFC28_60 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GFC28_602 ENOG4107QMU Mate efflux family protein GFC28_603 ENOG4105BZU Histidine kinase GFC28_604 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GFC28_61 ENOG4108R6K riboflavin synthase, subunit alpha GFC28_610 ENOG4105C7B Threonine dehydratase GFC28_614 ENOG4108WS4 fmn reductase GFC28_617 ENOG4105C1G acyl-Coa dehydrogenase GFC28_618 ENOG4105CEY Amp-dependent synthetase and ligase GFC28_619 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GFC28_62 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GFC28_620 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GFC28_621 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GFC28_622 ENOG4105E39 Enoyl-CoA hydratase GFC28_623 ENOG4107QX3 carboxylase GFC28_625 ENOG4105CW7 secretion protein, HlyD family GFC28_626 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC28_63 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GFC28_633 ENOG4108UZ3 Transporter GFC28_635 ENOG4105CJ1 ABC, transporter GFC28_640 ENOG4108HGU Histidine kinase GFC28_641 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GFC28_645 ENOG4105DVE abc transporter atp-binding protein GFC28_651 ENOG4105BZ1 (ABC) transporter GFC28_652 ENOG4105BZ1 (ABC) transporter GFC28_653 ENOG4108RPX mosc domain containing protein GFC28_657 ENOG410635A Membrane GFC28_659 ENOG4105D7K pfkb domain protein GFC28_66 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GFC28_662 ENOG4108VA3 3-hexulose-6-phosphate synthase GFC28_663 ENOG41080HJ 6-phospho 3-hexuloisomerase GFC28_665 ENOG41090WU lipolytic protein G-D-S-L family GFC28_666 ENOG4105CJ1 ABC, transporter GFC28_667 ENOG4108TU7 Inherit from COG: (ABC) transporter GFC28_668 ENOG4105P8F nudix hydrolase GFC28_669 ENOG4105SX7 Transporter GFC28_67 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GFC28_672 ENOG41082BM Transcriptional regulator, arsr family GFC28_674 ENOG4105VPX protein, conserved in bacteria GFC28_675 ENOG4105C59 p-type ATPase GFC28_676 ENOG4105C59 p-type ATPase GFC28_677 ENOG4108Z0Z intracellular protease Pfpi family GFC28_678 ENOG4108IPJ Membrane GFC28_680 ENOG4105DXB Major Facilitator superfamily GFC28_681 ENOG4107SWG transcriptional regulator MERR family GFC28_682 ENOG4105DEN Luciferase family GFC28_684 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GFC28_685 ENOG4105C7S Dehydrogenase GFC28_686 ENOG4105D5Q Arginine ornithine antiporter GFC28_688 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GFC28_689 ENOG4108UW5 maltose o-acetyltransferase GFC28_690 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC28_691 ENOG4107V2S Transcriptional regulator GFC28_692 ENOG4108PCN EamA-like transporter family GFC28_696 ENOG4105BZ1 (ABC) transporter GFC28_697 ENOG4105BZ1 (ABC) transporter GFC28_7 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GFC28_70 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GFC28_709 ENOG4105CE4 GlcNAc 6-P deacetylase GFC28_71 ENOG4105DZ1 carboxypeptidase GFC28_710 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GFC28_711 ENOG4105FDP GntR family transcriptional regulator GFC28_713 ENOG4108SU4 UPF0309 protein GFC28_714 ENOG4105D58 Diguanylate phosphodiesterase GFC28_715 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_719 ENOG4105DKW ABC transporter GFC28_72 ENOG4108JIC nucleoside recognition domain protein GFC28_725 ENOG4105E1F short-chain dehydrogenase reductase GFC28_726 ENOG4105C9U ATP-dependent DNA helicase RecQ GFC28_728 ENOG4108TVJ Nitroreductase GFC28_729 ENOG4108VGI doxx family GFC28_733 ENOG4105D8V Glucose sorbosone dehydrogenase GFC28_739 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GFC28_74 ENOG4105FE9 pseudouridine synthase GFC28_742 ENOG4108HHA Transketolase GFC28_745 ENOG4105CRW Short chain fatty acid transporter GFC28_747 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GFC28_75 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC28_751 ENOG4105BZ1 (ABC) transporter GFC28_752 ENOG4105BZ1 (ABC) transporter GFC28_757 ENOG4107TXC Transcriptional regulator GFC28_76 ENOG4107TWT Cytochrome c biogenesis protein GFC28_761 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GFC28_762 ENOG4105E0C molybdate abc transporter GFC28_763 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GFC28_764 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GFC28_765 ENOG4108J2R molybdopterin oxidoreductase GFC28_77 ENOG4105CRE cytochrome C GFC28_770 ENOG41062JF Transcriptional regulator GFC28_771 ENOG4105EYF MMPL domain protein GFC28_772 ENOG4108IG5 Transcriptional regulator GFC28_776 ENOG41082YX Transcriptional regulator, arsr family GFC28_777 ENOG4105D6J arsenicaL-resistance protein GFC28_778 ENOG4108UXE Protein tyrosine phosphatase GFC28_78 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC28_786 ENOG4105EC3 peptidase S51, dipeptidase E GFC28_788 ENOG4105KD7 acetyltransferase GFC28_79 ENOG4105BZU Histidine kinase GFC28_795 ENOG4107T89 von Willebrand factor, type A GFC28_796 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GFC28_798 ENOG4105CIY formyltetrahydrofolate deformylase GFC28_799 ENOG4105E0X reductase GFC28_800 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GFC28_801 ENOG4105KPV Transcriptional regulator GFC28_803 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GFC28_804 ENOG4105FDT acyl-CoA dehydrogenase GFC28_807 ENOG4107S6Z Na H antiporter GFC28_808 ENOG4107414 GntR family transcriptional regulator GFC28_809 ENOG4105CG3 alpha amylase, catalytic region GFC28_810 ENOG4105C5Y PTS System GFC28_811 ENOG4105C5Y PTS System GFC28_812 ENOG4105C5Y PTS System GFC28_815 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC28_816 ENOG4105K4P CoA-binding domain protein GFC28_82 ENOG4105BZ1 (ABC) transporter GFC28_820 ENOG4108PJD permease GFC28_821 ENOG4105CKI cobalamin synthesis protein GFC28_822 ENOG4105H20 Sporulation integral membrane protein YlbJ GFC28_83 ENOG4108QCI YvbH-like oligomerisation region GFC28_838 ENOG4108SAX Membrane GFC28_839 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GFC28_84 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GFC28_841 ENOG4108R5S membrane GFC28_842 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GFC28_843 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GFC28_845 ENOG41090WU lipolytic protein G-D-S-L family GFC28_846 ENOG4108KF3 Electron transport protein SCO1 SenC GFC28_847 ENOG4108RCR degv family GFC28_849 ENOG4105C7B Threonine dehydratase GFC28_85 ENOG4105EHG Permease protein GFC28_851 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GFC28_852 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GFC28_853 ENOG4106E8G GFC28_854 ENOG4105CHM Aminotransferase GFC28_856 ENOG4107YX5 Pfam:DUF548 GFC28_857 ENOG4108Y6J UPF0403 protein GFC28_86 ENOG4105E0A ABC, transporter GFC28_862 ENOG4108V06 Glutathione peroxidase GFC28_865 ENOG4105CVG Homoserine O-transsuccinylase GFC28_866 ENOG4105WMR Protein CrcB homolog GFC28_867 ENOG4105WMR Protein CrcB homolog GFC28_868 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GFC28_869 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GFC28_87 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GFC28_870 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GFC28_871 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GFC28_872 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GFC28_873 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GFC28_874 ENOG4108P62 biosynthesis protein (CbiG) GFC28_875 ENOG4105CIA precorrin-4 C(11)-methyltransferase GFC28_877 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase GFC28_878 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GFC28_879 ENOG41081F0 Precorrin-8x methylmutase GFC28_88 ENOG4107QZB decarboxylase GFC28_880 ENOG4108JTQ reductase GFC28_881 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GFC28_882 ENOG4105E4R Precorrin-3B C17-methyltransferase GFC28_883 ENOG4108JJB ABC transporter GFC28_885 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GFC28_886 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GFC28_893 ENOG4105DPN Oligoendopeptidase f GFC28_894 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GFC28_898 ENOG4105EXQ uroporphyrinogen iii synthase hem4 GFC28_9 ENOG4108ZVT methylmalonyl-coA epimerase GFC28_90 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GFC28_900 ENOG4105BZU Histidine kinase GFC28_901 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GFC28_904 ENOG4108PJD permease GFC28_905 ENOG4105DM4 PTS System GFC28_906 ENOG4105DE4 1-phosphofructokinase GFC28_907 ENOG4105E98 transcriptional regulator DeoR family GFC28_908 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GFC28_910 ENOG4105RWS endonuclease I GFC28_911 ENOG4107S6Z Na H antiporter GFC28_912 ENOG4105V75 Transcriptional regulator GFC28_915 ENOG4105DY9 regulatoR GFC28_916 ENOG4108HRK Histidine kinase GFC28_918 ENOG4105CGU Enoyl-CoA hydratase GFC28_922 ENOG4105MKU Transcriptional regulator GFC28_923 ENOG4105CMG Carbohydrate kinase GFC28_924 ENOG4105C93 Xylose Isomerase GFC28_925 ENOG4105CTM Glycoside hydrolase family 5 GFC28_929 ENOG4105DMW Dehydrogenase reductase GFC28_93 ENOG4108WBT adenosyltransferase GFC28_931 ENOG4105D2H Uronic isomerase GFC28_932 ENOG4107XBN GntR Family Transcriptional Regulator GFC28_936 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GFC28_943 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GFC28_944 ENOG4105XN3 extracellular solute-binding protein family 1 GFC28_945 ENOG4105EQD regulatoR GFC28_946 ENOG4105C2F Histidine kinase GFC28_948 ENOG4107SET aldo keto reductase GFC28_949 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GFC28_951 ENOG4105CNN ABC, transporter GFC28_952 ENOG4105C2J ABC transporter GFC28_953 ENOG4105DFW ABC transporter GFC28_956 ENOG4105EF1 ribulokinase GFC28_959 ENOG4108HWW ABC transporter GFC28_961 ENOG4105DFW ABC transporter GFC28_962 ENOG4105EQD regulatoR GFC28_963 ENOG4105C2F Histidine kinase GFC28_965 ENOG41086D8 Transcriptional regulator GFC28_968 ENOG4106YBV Methyl-accepting chemotaxis GFC28_969 ENOG4105C8Q Methyl-accepting chemotaxis GFC28_971 ENOG4105ZKE UPF0349 protein GFC28_975 ENOG4105EAD ABC transporter GFC28_976 ENOG4105DRP amino acid AbC transporter GFC28_979 ENOG410829K Lysine exporter protein (Lyse ygga) GFC28_98 ENOG4107RVV histidinol phosphate phosphatase, hisj family GFC28_981 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GFC28_982 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GFC28_984 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GFC28_986 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GFC28_987 ENOG4105C26 Dehydrogenase GFC28_988 ENOG4105G9B Transcriptional regulator GFC28_99 ENOG4108JQ1 Dehydrogenase GFC28_991 ENOG4107SJI Dehydrogenase GFC28_997 ENOG4105BZ8 glutamate synthase GFC28_998 ENOG4105CBC glutamate synthase GFC28_999 ENOG4105C5Q Transcriptional regulator