locus-tag	class	description
GFC28_10	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFC28_1001	COG1113	amino acid transport
GFC28_1003	COG1070	Carbohydrate kinase
GFC28_1004	COG1609	Transcriptional regulator
GFC28_1005	COG0456	acetyltransferase
GFC28_1005	COG1846	Transcriptional regulator
GFC28_1007	COG1609	Transcriptional regulator
GFC28_1008	COG0456	acetyltransferase
GFC28_1009	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GFC28_1015	COG5577	PFAM Coat F domain
GFC28_1017	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFC28_1018	COG0840	transmembrane signaling receptor activity
GFC28_1022	COG2208	phosphoserine phosphatase activity
GFC28_1026	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFC28_1028	COG0789	Transcriptional regulator
GFC28_1028	COG4978	Transcriptional regulator
GFC28_1029	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFC28_103	COG0514	ATP-dependent DNA helicase (RecQ)
GFC28_1030	COG0800	Aldolase
GFC28_1031	COG1082	Xylose isomerase domain protein TIM barrel
GFC28_1032	COG0673	inositol 2-dehydrogenase activity
GFC28_1033	COG0673	inositol 2-dehydrogenase activity
GFC28_1034	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFC28_1035	COG1742	UPF0060 membrane protein
GFC28_104	COG1266	CAAX protease self-immunity
GFC28_1042	COG2223	nitrite transmembrane transporter activity
GFC28_1043	COG0506	proline dehydrogenase activity
GFC28_1044	COG1012	belongs to the aldehyde dehydrogenase family
GFC28_1045	COG2508	Transcriptional regulator
GFC28_1048	COG3037	sugar-specific permease SgaT UlaA
GFC28_1050	COG0747	negative chemotaxis
GFC28_1052	COG0601	transmembrane transport
GFC28_1053	COG4608	Belongs to the ABC transporter superfamily
GFC28_1055	COG0840	transmembrane signaling receptor activity
GFC28_1057	COG4214	carbohydrate transport
GFC28_1058	COG1129	ABC transporter
GFC28_1059	COG4213	ABC transporter substrate-binding protein
GFC28_1060	COG3279	Response regulator of the LytR AlgR family
GFC28_1061	COG2972	Histidine kinase
GFC28_1063	COG5001	Diguanylate cyclase
GFC28_1063	COG3300	MHYT domain
GFC28_1069	COG0328	RNA-DNA hybrid ribonuclease activity
GFC28_107	COG3546	catalase activity
GFC28_1070	COG0328	RNA-DNA hybrid ribonuclease activity
GFC28_1073	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GFC28_1075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFC28_1079	COG3773	Cell wall hydrolase
GFC28_1081	COG4846	Membrane protein involved in cytochrome C biogenesis
GFC28_1082	COG2201	protein-glutamate methylesterase activity
GFC28_1083	COG0785	Cytochrome C biogenesis protein
GFC28_1085	COG3763	UPF0154 protein
GFC28_1088	COG4224	UPF0291 protein
GFC28_1089	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFC28_1090	COG1388	LysM domain
GFC28_1091	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GFC28_1100	COG1388	LysM domain
GFC28_1101	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFC28_1105	COG4942	peptidase
GFC28_1106	COG3328	transposase activity
GFC28_1108	COG0174	glutamine synthetase
GFC28_1109	COG0789	Transcriptional regulator
GFC28_111	COG1408	metallophosphoesterase
GFC28_1110	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GFC28_1111	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFC28_1112	COG2860	membrane
GFC28_1113	COG0183	Belongs to the thiolase family
GFC28_1114	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFC28_1115	COG0318	PFAM AMP-dependent synthetase and ligase
GFC28_1119	COG0464	growth
GFC28_1120	COG1923	regulation of RNA biosynthetic process
GFC28_1121	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFC28_1122	COG0840	transmembrane signaling receptor activity
GFC28_1123	COG0477	Major facilitator Superfamily
GFC28_1124	COG2814	Major facilitator Superfamily
GFC28_1125	COG1664	Polymer-forming cytoskeletal
GFC28_1126	COG1664	Polymer-forming cytoskeletal
GFC28_1127	COG0789	Transcriptional regulator
GFC28_1129	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GFC28_113	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFC28_1130	COG4549	nuclear export factor GLE1
GFC28_1131	COG1276	copper resistance
GFC28_1131	COG2372	response to copper ion
GFC28_1132	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFC28_1134	COG1376	ErfK ybiS ycfS ynhG family protein
GFC28_1139	COG1131	(ABC) transporter
GFC28_114	COG0492	ferredoxin-NADP+ reductase activity
GFC28_1140	COG2340	Cysteine-rich secretory protein family
GFC28_1143	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFC28_1145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFC28_1145	COG1263	PTS System
GFC28_1146	COG1737	Transcriptional regulator
GFC28_1147	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFC28_1148	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFC28_1151	COG4550	Control of competence regulator ComK, YlbF/YmcA
GFC28_1152	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFC28_1153	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFC28_1154	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFC28_1154	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFC28_1156	COG2359	stage V sporulation protein S
GFC28_1157	COG1692	metallophosphoesterase
GFC28_1158	COG1418	mRNA catabolic process
GFC28_1159	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFC28_1160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFC28_1161	COG1546	Belongs to the CinA family
GFC28_1161	COG1058	Belongs to the CinA family
GFC28_1162	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFC28_1163	COG1426	Protein conserved in bacteria
GFC28_1166	COG0300	oxidoreductase activity
GFC28_1167	COG0612	Peptidase, M16
GFC28_1168	COG0612	Peptidase, M16
GFC28_1173	COG2188	Transcriptional regulator
GFC28_1174	COG1674	ftsk spoiiie
GFC28_1174	COG4980	gas vesicle protein
GFC28_1176	COG0740	serine-type endopeptidase activity
GFC28_1177	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFC28_1179	COG0527	aspartate kinase activity
GFC28_1180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFC28_1181	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFC28_1182	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFC28_1183	COG1873	PFAM PRC-barrel domain
GFC28_1184	COG0612	Peptidase, M16
GFC28_1185	COG0726	polysaccharide deacetylase
GFC28_1186	COG1185	polyribonucleotide nucleotidyltransferase activity
GFC28_1187	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFC28_1188	COG0196	riboflavin kinase activity
GFC28_1189	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFC28_119	COG1309	transcriptional regulator
GFC28_1190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFC28_1191	COG1550	Protein conserved in bacteria
GFC28_1192	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFC28_1193	COG1358	cellular component organization or biogenesis
GFC28_1194	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GFC28_1195	COG0195	Participates in both transcription termination and antitermination
GFC28_1196	COG0779	Required for maturation of 30S ribosomal subunits
GFC28_1197	COG2176	DNA-directed DNA polymerase activity
GFC28_1198	COG0442	prolyl-tRNA aminoacylation
GFC28_1199	COG0750	zinc metalloprotease
GFC28_12	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFC28_120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFC28_1200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GFC28_1201	COG4589	Belongs to the CDS family
GFC28_1202	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFC28_1203	COG0233	cytoplasmic translational termination
GFC28_1204	COG0528	UMP kinase activity
GFC28_1205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFC28_1206	COG0052	Belongs to the universal ribosomal protein uS2 family
GFC28_1209	COG1191	sigma factor activity
GFC28_121	COG2339	peptidase activity
GFC28_1211	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GFC28_1212	COG1776	CheC inhibitor of MCP methylation
GFC28_1213	COG0835	chemotaxis
GFC28_1214	COG2198	Histidine kinase
GFC28_1214	COG0643	Histidine kinase
GFC28_1215	COG2201	protein-glutamate methylesterase activity
GFC28_1216	COG0455	bacterial-type flagellum organization
GFC28_1217	COG1419	protein localization to endoplasmic reticulum
GFC28_1218	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GFC28_1219	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GFC28_122	COG3409	Peptidoglycan-binding domain 1 protein
GFC28_122	COG3773	Cell wall hydrolase
GFC28_1220	COG1684	flagellar biosynthetic protein fliR
GFC28_1221	COG1987	bacterial-type flagellum assembly
GFC28_1222	COG1338	Plays a role in the flagellum-specific transport system
GFC28_1223	COG3190	flagellar
GFC28_1224	COG2201	protein-glutamate methylesterase activity
GFC28_1225	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GFC28_1225	COG1776	CheC inhibitor of MCP methylation
GFC28_1226	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GFC28_1227	COG1580	Controls the rotational direction of flagella during chemotaxis
GFC28_1228	COG1582	Flagellar protein (FlbD)
GFC28_1229	COG4786	Flagellar basal body rod
GFC28_123	COG2959	enzyme of heme biosynthesis
GFC28_1230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GFC28_1231	COG3144	bacterial-type flagellum assembly
GFC28_1233	COG2882	bacterial-type flagellum organization
GFC28_1234	COG1157	protein secretion by the type III secretion system
GFC28_1235	COG1317	bacterial-type flagellum organization
GFC28_1236	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GFC28_1237	COG1766	The M ring may be actively involved in energy transduction
GFC28_1238	COG1677	Flagellar hook-basal body complex protein FliE
GFC28_1239	COG1558	bacterial-type flagellum-dependent cell motility
GFC28_124	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GFC28_1240	COG1815	bacterial-type flagellum-dependent cell motility
GFC28_1241	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GFC28_1242	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GFC28_1243	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GFC28_1244	COG4974	Belongs to the 'phage' integrase family
GFC28_1245	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GFC28_1246	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFC28_1247	COG0758	DNA mediated transformation
GFC28_1248	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFC28_1249	COG0045	succinate-CoA ligase (ADP-forming) activity
GFC28_1250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GFC28_1252	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFC28_1253	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFC28_1255	COG0335	large ribosomal subunit rRNA binding
GFC28_1256	COG0336	Belongs to the RNA methyltransferase TrmD family
GFC28_1257	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFC28_1259	COG1837	Belongs to the UPF0109 family
GFC28_126	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFC28_1260	COG0228	four-way junction DNA binding
GFC28_1261	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFC28_1262	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GFC28_1263	COG0552	protein localization to endoplasmic reticulum
GFC28_1264	COG1196	nuclear chromosome segregation
GFC28_1265	COG0571	ribonuclease III activity
GFC28_1266	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFC28_1267	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_1268	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFC28_1269	COG0416	fatty acid biosynthetic process
GFC28_127	COG0204	Acyl-transferase
GFC28_1270	COG1349	DNA-binding transcription factor activity
GFC28_1271	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFC28_1272	COG1760	l-serine dehydratase
GFC28_1273	COG1760	l-serine dehydratase
GFC28_1274	COG1461	Dihydroxyacetone kinase
GFC28_1275	COG1302	Protein conserved in bacteria
GFC28_1276	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFC28_1277	COG1564	THIamine pyrophosphokinase
GFC28_1278	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFC28_1279	COG1162	GTPase activity
GFC28_128	COG0539	negative regulation of cytoplasmic translation
GFC28_1280	COG2815	serine threonine protein kinase
GFC28_1280	COG0515	serine threonine protein kinase
GFC28_1281	COG0631	protein serine/threonine phosphatase activity
GFC28_1282	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFC28_1283	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFC28_1283	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFC28_1284	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFC28_1285	COG0242	peptide deformylase activity
GFC28_1286	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFC28_1287	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFC28_1288	COG1758	RNA polymerase activity
GFC28_1289	COG0194	GDP metabolic process
GFC28_129	COG1304	FMN binding
GFC28_1290	COG2052	Domain of unknown function (DUF370)
GFC28_1291	COG1561	YicC-like family, N-terminal region
GFC28_1292	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFC28_1296	COG0284	orotidine-5'-phosphate decarboxylase activity
GFC28_1297	COG0167	dihydroorotate dehydrogenase activity
GFC28_1298	COG0543	2 iron, 2 sulfur cluster binding
GFC28_1301	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFC28_1302	COG0540	Belongs to the ATCase OTCase family
GFC28_1304	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFC28_1305	COG0564	pseudouridine synthase activity
GFC28_1306	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFC28_1307	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFC28_1308	COG3599	regulation of cell shape
GFC28_1309	COG2302	S4 RNA-binding domain
GFC28_1310	COG0762	integral membrane protein
GFC28_1311	COG1799	cell septum assembly
GFC28_1312	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFC28_1314	COG1873	PFAM PRC-barrel domain
GFC28_1315	COG1191	sigma factor activity
GFC28_1316	COG1191	sigma factor activity
GFC28_1318	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFC28_1319	COG0849	cell division
GFC28_1320	COG3856	small basic protein
GFC28_1321	COG3879	Bacterial protein of unknown function (DUF881)
GFC28_1322	COG3879	Bacterial protein of unknown function (DUF881)
GFC28_1323	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GFC28_1324	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFC28_1325	COG0772	Belongs to the SEDS family
GFC28_1326	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFC28_1327	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFC28_1329	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFC28_133	COG1160	GTP binding
GFC28_1330	COG0768	penicillin binding
GFC28_1332	COG4839	cell division protein FtsL
GFC28_1333	COG0275	rRNA processing
GFC28_1334	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GFC28_1336	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFC28_1338	COG1024	Enoyl-CoA hydratase
GFC28_1339	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFC28_134	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFC28_1340	COG1399	metal-binding, possibly nucleic acid-binding protein
GFC28_1341	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFC28_1342	COG1323	Belongs to the UPF0348 family
GFC28_1343	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFC28_1344	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFC28_1345	COG0742	ribosomal rna small subunit methyltransferase
GFC28_1348	COG4471	UPF0298 protein
GFC28_1349	COG3679	Belongs to the UPF0342 family
GFC28_1353	COG2340	Cysteine-rich secretory protein family
GFC28_1354	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GFC28_1355	COG2340	Cysteine-rich secretory protein family
GFC28_1359	COG3336	cytochrome c oxidase
GFC28_1364	COG0109	protoheme IX farnesyltransferase activity
GFC28_1365	COG1612	heme a metabolic process
GFC28_1366	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GFC28_1367	COG0772	Belongs to the SEDS family
GFC28_1368	COG4838	Belongs to the UPF0358 family
GFC28_1369	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFC28_137	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GFC28_1370	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GFC28_1373	COG4896	Protein conserved in bacteria
GFC28_1378	COG0483	inositol monophosphate 1-phosphatase activity
GFC28_1380	COG4476	Belongs to the UPF0223 family
GFC28_1382	COG1982	Orn Lys Arg decarboxylase major
GFC28_139	COG0302	gtp cyclohydrolase
GFC28_1393	COG0561	phosphatase activity
GFC28_1396	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFC28_1397	COG0569	domain protein
GFC28_1398	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_1399	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_14	COG2076	Multidrug Resistance protein
GFC28_1400	COG0450	alkyl hydroperoxide reductase
GFC28_1402	COG1473	amidohydrolase
GFC28_1403	COG2171	N-acyltransferase activity
GFC28_1404	COG0583	DNA-binding transcription factor activity
GFC28_1406	COG0517	IMP dehydrogenase activity
GFC28_1409	COG4703	Protein of unknown function (DUF1797)
GFC28_1411	COG2200	EAL domain
GFC28_1412	COG4990	cell redox homeostasis
GFC28_1413	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_1414	COG1408	metallophosphoesterase
GFC28_1415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFC28_1416	COG0248	Ppx GppA phosphatase
GFC28_1418	COG0784	Response regulator, receiver
GFC28_1418	COG0835	chemotaxis
GFC28_142	COG2226	methyltransferase
GFC28_1420	COG2205	protein histidine kinase activity
GFC28_1423	COG0598	Magnesium transport protein CorA
GFC28_1425	COG0436	Aminotransferase
GFC28_1426	COG2084	Dehydrogenase
GFC28_1427	COG2314	TM2 domain
GFC28_1429	COG0840	transmembrane signaling receptor activity
GFC28_1432	COG2190	(PTS) system
GFC28_1432	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFC28_1432	COG1263	PTS System
GFC28_1433	COG3711	transcriptional antiterminator
GFC28_1435	COG2267	carboxylic ester hydrolase activity
GFC28_1436	COG0475	glutathione-regulated potassium exporter activity
GFC28_1438	COG5001	Diguanylate cyclase
GFC28_144	COG0105	UTP biosynthetic process
GFC28_1442	COG0778	Nitroreductase
GFC28_1443	COG4191	Histidine kinase
GFC28_145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GFC28_1450	COG3773	Cell wall hydrolase
GFC28_1451	COG4873	Protein conserved in bacteria
GFC28_1452	COG0702	epimerase
GFC28_1453	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GFC28_1456	COG0720	synthase
GFC28_1457	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GFC28_146	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFC28_1462	COG3949	Membrane
GFC28_1464	COG0542	response to heat
GFC28_1467	COG0410	ABC transporter
GFC28_147	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFC28_1470	COG0559	Belongs to the binding-protein-dependent transport system permease family
GFC28_1473	COG1131	(ABC) transporter
GFC28_1475	COG0531	amino acid
GFC28_1476	COG1846	Transcriptional regulator
GFC28_1477	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GFC28_1478	COG0235	Class ii aldolase
GFC28_1479	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GFC28_148	COG4401	Chorismate mutase type I
GFC28_1480	COG1850	ribulose-bisphosphate carboxylase activity
GFC28_1481	COG0436	Aminotransferase
GFC28_1482	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFC28_1483	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GFC28_1484	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GFC28_1485	COG1879	ABC-type sugar transport system periplasmic component
GFC28_1486	COG1129	ABC transporter
GFC28_1487	COG4211	Belongs to the binding-protein-dependent transport system permease family
GFC28_1489	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFC28_1490	COG5002	protein histidine kinase activity
GFC28_1495	COG1063	alcohol dehydrogenase
GFC28_1496	COG2814	Major facilitator Superfamily
GFC28_1498	COG0395	ABC-type sugar transport system, permease component
GFC28_150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFC28_1500	COG1653	transport
GFC28_1502	COG1609	Transcriptional regulator
GFC28_1505	COG0531	amino acid
GFC28_1506	COG3162	membrane
GFC28_1507	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFC28_1509	COG4948	Mandelate Racemase Muconate Lactonizing
GFC28_151	COG0134	indole-3-glycerol-phosphate synthase activity
GFC28_1511	COG1473	amidohydrolase
GFC28_1513	COG2966	Psort location CytoplasmicMembrane, score
GFC28_1514	COG0490	domain, Protein
GFC28_1515	COG0475	glutathione-regulated potassium exporter activity
GFC28_1516	COG1414	Transcriptional regulator
GFC28_1517	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFC28_1518	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GFC28_1519	COG0277	FAD linked oxidase domain protein
GFC28_152	COG0135	phosphoribosylanthranilate isomerase activity
GFC28_1520	COG0247	lactate metabolic process
GFC28_1521	COG0277	FAD linked oxidase domain protein
GFC28_154	COG0159	tryptophan synthase activity
GFC28_1542	COG0840	transmembrane signaling receptor activity
GFC28_1546	COG4758	membrane
GFC28_1547	COG4585	Histidine kinase
GFC28_1548	COG2197	response regulator
GFC28_155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFC28_1550	COG0656	L-ascorbic acid biosynthetic process
GFC28_1551	COG2814	Major facilitator Superfamily
GFC28_1552	COG1733	regulation of RNA biosynthetic process
GFC28_1554	COG1027	Aspartate ammonia-lyase
GFC28_1555	COG0252	asparaginase activity
GFC28_1556	COG1396	sequence-specific DNA binding
GFC28_1557	COG1316	TRANSCRIPTIONal
GFC28_1559	COG0346	lactoylglutathione lyase activity
GFC28_156	COG0287	Prephenate dehydrogenase
GFC28_1560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFC28_1561	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFC28_1564	COG0579	oxidoreductase
GFC28_1567	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFC28_1568	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFC28_1569	COG3162	membrane
GFC28_157	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFC28_1571	COG0196	riboflavin kinase activity
GFC28_1576	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFC28_1577	COG0583	DNA-binding transcription factor activity
GFC28_1579	COG0494	nUDIX hydrolase
GFC28_1581	COG2066	Belongs to the glutaminase family
GFC28_1588	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_1589	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_159	COG0457	Tetratricopeptide repeat
GFC28_1590	COG1120	ATPase activity
GFC28_1591	COG3739	integral membrane protein
GFC28_1592	COG3655	Transcriptional regulator
GFC28_1603	COG0114	fumarate hydratase activity
GFC28_1604	COG0400	carboxylic ester hydrolase activity
GFC28_1607	COG3775	system Galactitol-specific IIC component
GFC28_1608	COG3414	Phosphotransferase system galactitol-specific IIB component
GFC28_1610	COG2390	Transcriptional regulator
GFC28_1611	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFC28_1612	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFC28_1613	COG0022	dehydrogenase e1 component
GFC28_1613	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFC28_1614	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFC28_1615	COG2390	Transcriptional regulator
GFC28_1617	COG3732	PTS system glucitol sorbitol-specific
GFC28_1618	COG3730	PTS system glucitol sorbitol-specific
GFC28_1625	COG4821	SIS domain
GFC28_1633	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFC28_1634	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFC28_1639	COG4989	oxidoreductase activity
GFC28_1641	COG0494	nUDIX hydrolase
GFC28_165	COG4347	Protein of unknown function (DUF1405)
GFC28_1652	COG0367	asparagine synthase
GFC28_1653	COG4990	cell redox homeostasis
GFC28_1654	COG2132	Multicopper oxidase
GFC28_1658	COG0785	Cytochrome C biogenesis protein
GFC28_1659	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_1660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFC28_1661	COG1333	cytochrome c biogenesis protein
GFC28_1667	COG5002	protein histidine kinase activity
GFC28_1668	COG0745	RESPONSE REGULATOR receiver
GFC28_167	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFC28_1670	COG3336	cytochrome c oxidase
GFC28_1672	COG2217	Heavy metal translocating P-type atpase
GFC28_1673	COG1937	Protein conserved in bacteria
GFC28_168	COG1694	Mazg nucleotide pyrophosphohydrolase
GFC28_1688	COG2226	methyltransferase
GFC28_169	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFC28_1692	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_1695	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFC28_17	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFC28_170	COG1803	Methylglyoxal synthase
GFC28_1701	COG0791	NLP P60 protein
GFC28_1701	COG1388	LysM domain
GFC28_1703	COG0745	RESPONSE REGULATOR receiver
GFC28_1704	COG5002	protein histidine kinase activity
GFC28_1705	COG0531	amino acid
GFC28_171	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFC28_1714	COG1126	abc transporter atp-binding protein
GFC28_1715	COG0765	amino acid transport
GFC28_172	COG0438	transferase activity, transferring glycosyl groups
GFC28_173	COG0617	tRNA 3'-terminal CCA addition
GFC28_1738	COG0582	viral genome integration into host DNA
GFC28_1740	COG1418	mRNA catabolic process
GFC28_1742	COG0583	DNA-binding transcription factor activity
GFC28_1745	COG0626	cystathionine gamma-synthase activity
GFC28_1746	COG0626	cystathionine gamma-synthase activity
GFC28_1747	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_1748	COG2610	gluconate transmembrane transporter activity
GFC28_175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFC28_1751	COG2382	esterase
GFC28_1752	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GFC28_1753	COG2153	protein acetylation
GFC28_1756	COG0210	DNA helicase
GFC28_176	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GFC28_1760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_1762	COG2323	membrane
GFC28_1765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFC28_177	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GFC28_1775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFC28_1776	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFC28_1777	COG0438	transferase activity, transferring glycosyl groups
GFC28_1778	COG0438	transferase activity, transferring glycosyl groups
GFC28_1779	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GFC28_178	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFC28_178	COG1199	ATP-dependent helicase activity
GFC28_1782	COG0772	Belongs to the SEDS family
GFC28_1783	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GFC28_1784	COG0564	pseudouridine synthase activity
GFC28_1785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFC28_1786	COG2357	RelA SpoT domain protein
GFC28_1788	COG4116	CYTH
GFC28_1789	COG0741	lytic transglycosylase activity
GFC28_1790	COG2346	COG2346, Truncated hemoglobins
GFC28_1793	COG1164	Oligoendopeptidase f
GFC28_1795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFC28_1796	COG4862	establishment of competence for transformation
GFC28_1797	COG0861	Integral membrane protein TerC family
GFC28_1798	COG1393	Belongs to the ArsC family
GFC28_180	COG5353	protein conserved in bacteria
GFC28_1800	COG4608	Belongs to the ABC transporter superfamily
GFC28_1801	COG0444	Belongs to the ABC transporter superfamily
GFC28_1802	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFC28_1803	COG0601	transmembrane transport
GFC28_1804	COG4166	transmembrane transport
GFC28_1808	COG5504	Zn-dependent protease
GFC28_1809	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFC28_1810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFC28_1813	COG2267	carboxylic ester hydrolase activity
GFC28_1817	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFC28_182	COG0017	Asparaginyl-tRNA synthetase
GFC28_1821	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFC28_1822	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GFC28_1823	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFC28_1825	COG0314	molybdopterin synthase activity
GFC28_1826	COG1763	Mo-molybdopterin cofactor biosynthetic process
GFC28_1827	COG0303	'Molybdopterin
GFC28_1828	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFC28_1829	COG0746	molybdenum cofactor guanylyltransferase activity
GFC28_183	COG3935	DnaD domain protein
GFC28_1830	COG1073	alpha beta
GFC28_1831	COG0561	phosphatase activity
GFC28_1833	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFC28_1834	COG1307	EDD domain protein, DegV family
GFC28_1836	COG2197	response regulator
GFC28_1837	COG4585	Histidine kinase
GFC28_1838	COG1131	(ABC) transporter
GFC28_184	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFC28_1840	COG0842	Transport permease protein
GFC28_1841	COG0840	transmembrane signaling receptor activity
GFC28_1843	COG2996	Protein conserved in bacteria
GFC28_1845	COG0646	methionine synthase
GFC28_1845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GFC28_1846	COG1410	methionine synthase
GFC28_1846	COG0646	methionine synthase
GFC28_1847	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_1850	COG0366	Alpha amylase catalytic
GFC28_1851	COG3833	ABC-type maltose transport systems, permease component
GFC28_1852	COG1175	transmembrane transport
GFC28_1853	COG2182	Extracellular solute-binding protein
GFC28_1855	COG1917	Cupin 2, conserved barrel domain protein
GFC28_1855	COG2207	Transcriptional regulator
GFC28_1856	COG0534	Mate efflux family protein
GFC28_1857	COG0367	asparagine synthase
GFC28_186	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFC28_186	COG4499	WXG100 protein secretion system (Wss), protein YukC
GFC28_1860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFC28_1861	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFC28_1862	COG2311	Membrane
GFC28_1863	COG0318	PFAM AMP-dependent synthetase and ligase
GFC28_187	COG3331	DNA recombination
GFC28_1872	COG0419	ATPase involved in DNA repair
GFC28_1873	COG0420	3'-5' exonuclease activity
GFC28_1874	COG1074	ATP-dependent DNA helicase activity
GFC28_1875	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GFC28_1877	COG0398	Pfam SNARE associated Golgi protein
GFC28_1878	COG4903	ComK protein
GFC28_1881	COG2224	Isocitrate lyase
GFC28_1882	COG0501	Belongs to the peptidase M48B family
GFC28_1885	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GFC28_1886	COG0318	PFAM AMP-dependent synthetase and ligase
GFC28_1887	COG1234	tRNA 3'-trailer cleavage
GFC28_1891	COG1653	transport
GFC28_1892	COG1609	Transcriptional regulator
GFC28_1893	COG1511	domain protein
GFC28_1894	COG1309	transcriptional regulator
GFC28_1897	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GFC28_1898	COG1473	amidohydrolase
GFC28_1899	COG3069	C4-dicarboxylate transmembrane transporter activity
GFC28_1900	COG2329	Antibiotic biosynthesis monooxygenase
GFC28_1901	COG4473	ABC transporter
GFC28_1902	COG1131	(ABC) transporter
GFC28_1903	COG0537	adenosine 5'-monophosphoramidase activity
GFC28_1904	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFC28_1906	COG1846	Transcriptional regulator
GFC28_1910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GFC28_1912	COG3481	metal-dependent phosphohydrolase, HD sub domain
GFC28_1913	COG1668	transmembrane transport
GFC28_1914	COG4152	abc transporter atp-binding protein
GFC28_1916	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFC28_1917	COG0561	phosphatase activity
GFC28_1918	COG3679	Belongs to the UPF0342 family
GFC28_1919	COG4399	Belongs to the UPF0754 family
GFC28_1922	COG2508	Transcriptional regulator
GFC28_1923	COG3842	ATPase activity
GFC28_1926	COG1126	abc transporter atp-binding protein
GFC28_1927	COG0765	amino acid transport
GFC28_1928	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFC28_1929	COG1253	flavin adenine dinucleotide binding
GFC28_1931	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFC28_1932	COG2022	thiamine diphosphate biosynthetic process
GFC28_1933	COG2104	thiamine diphosphate biosynthetic process
GFC28_1934	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFC28_1935	COG0352	thiamine-phosphate diphosphorylase activity
GFC28_1936	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GFC28_1937	COG1122	ATPase activity
GFC28_1939	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFC28_1941	COG2318	DinB family
GFC28_1942	COG0366	Alpha amylase catalytic
GFC28_1943	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFC28_1944	COG2879	small protein
GFC28_1945	COG1966	Carbon starvation protein
GFC28_1947	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFC28_1948	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFC28_1949	COG0861	Integral membrane protein TerC family
GFC28_195	COG0745	RESPONSE REGULATOR receiver
GFC28_1951	COG0716	FMN binding
GFC28_1952	COG2514	catechol 2,3-dioxygenase activity
GFC28_1953	COG0730	response to heat
GFC28_1954	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFC28_1954	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFC28_1955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFC28_1955	COG0425	Belongs to the sulfur carrier protein TusA family
GFC28_1958	COG2210	Belongs to the sulfur carrier protein TusA family
GFC28_1959	COG0425	Belongs to the sulfur carrier protein TusA family
GFC28_196	COG5002	protein histidine kinase activity
GFC28_1960	COG1937	Protein conserved in bacteria
GFC28_1963	COG2719	SpoVR family
GFC28_1967	COG0586	Pfam SNARE associated Golgi protein
GFC28_1972	COG2197	response regulator
GFC28_1973	COG4585	Histidine kinase
GFC28_1973	COG2203	Gaf domain
GFC28_1974	COG4221	oxidoreductase activity
GFC28_1975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFC28_1976	COG0517	IMP dehydrogenase activity
GFC28_1978	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GFC28_198	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GFC28_1981	COG0564	pseudouridine synthase activity
GFC28_1982	COG1253	flavin adenine dinucleotide binding
GFC28_1983	COG2738	Putative neutral zinc metallopeptidase
GFC28_1986	COG0656	L-ascorbic acid biosynthetic process
GFC28_1987	COG0655	NAD(P)H dehydrogenase (quinone) activity
GFC28_1988	COG1741	Belongs to the pirin family
GFC28_1989	COG1301	dicarboxylic acid transport
GFC28_1990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GFC28_1991	COG3290	protein histidine kinase activity
GFC28_1994	COG5002	protein histidine kinase activity
GFC28_1994	COG3850	Histidine kinase
GFC28_1995	COG1136	(ABC) transporter
GFC28_1995	COG0577	efflux transmembrane transporter activity
GFC28_1996	COG1136	(ABC) transporter
GFC28_20	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GFC28_200	COG2217	Heavy metal translocating P-type atpase
GFC28_2000	COG2766	serine protein kinase
GFC28_2002	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GFC28_2004	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFC28_2005	COG3382	B3 4 domain protein
GFC28_201	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFC28_202	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFC28_203	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GFC28_2037	COG0735	belongs to the Fur family
GFC28_2038	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFC28_2042	COG4555	ABC transporter
GFC28_2043	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFC28_2044	COG0070	glutamate synthase
GFC28_2044	COG0069	glutamate synthase activity
GFC28_2044	COG0067	glutamate synthase
GFC28_2048	COG4129	membrane
GFC28_2052	COG0747	negative chemotaxis
GFC28_2053	COG4608	Belongs to the ABC transporter superfamily
GFC28_2054	COG0444	Belongs to the ABC transporter superfamily
GFC28_2055	COG3557	Belongs to the UPF0374 family
GFC28_2058	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_206	COG3706	GGDEF domain
GFC28_2061	COG1988	membrane-bound metal-dependent
GFC28_2068	COG2137	regulation of response to DNA damage stimulus
GFC28_2069	COG1090	epimerase
GFC28_207	COG3706	GGDEF domain
GFC28_207	COG4251	negative regulation of phosphorylation
GFC28_207	COG5001	Diguanylate cyclase
GFC28_207	COG2203	Gaf domain
GFC28_2075	COG2197	response regulator
GFC28_2077	COG1607	acyl-coa hydrolase
GFC28_2078	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFC28_2081	COG2079	MmgE PrpD family protein
GFC28_2082	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GFC28_2085	COG0733	neurotransmitter:sodium symporter activity
GFC28_2094	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GFC28_21	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GFC28_2108	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFC28_2109	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GFC28_2113	COG0535	radical SAM domain protein
GFC28_2116	COG0387	Pfam Sodium calcium exchanger
GFC28_2118	COG0477	Major facilitator Superfamily
GFC28_2120	COG1295	ribonuclease BN
GFC28_2122	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFC28_2123	COG4840	Belongs to the UPF0435 family
GFC28_2125	COG0175	sulfate reduction
GFC28_2126	COG0306	phosphate transporter
GFC28_2127	COG2046	Belongs to the sulfate adenylyltransferase family
GFC28_2128	COG0529	Catalyzes the synthesis of activated sulfate
GFC28_2129	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFC28_2133	COG1254	Belongs to the acylphosphatase family
GFC28_2134	COG0010	Belongs to the arginase family
GFC28_2135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFC28_2140	COG5001	Diguanylate cyclase
GFC28_2140	COG1716	ATPase activity
GFC28_2143	COG1388	LysM domain
GFC28_2143	COG0791	NLP P60 protein
GFC28_2144	COG0247	lactate metabolic process
GFC28_2145	COG0277	FAD linked oxidase domain protein
GFC28_2146	COG1620	l-lactate permease
GFC28_2147	COG2186	Transcriptional regulator
GFC28_2148	COG0247	lactate metabolic process
GFC28_2149	COG1139	Iron-sulfur cluster binding protein
GFC28_2150	COG1556	Lactate utilization protein
GFC28_2151	COG0861	Integral membrane protein TerC family
GFC28_2152	COG1228	amidohydrolase
GFC28_2153	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GFC28_2154	COG2986	histidine ammonia-lyase
GFC28_2159	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFC28_2160	COG2068	MobA-Related Protein
GFC28_2161	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFC28_2164	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GFC28_2165	COG0840	transmembrane signaling receptor activity
GFC28_2165	COG3290	protein histidine kinase activity
GFC28_2166	COG2084	Dehydrogenase
GFC28_2167	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GFC28_2168	COG0833	amino acid
GFC28_2169	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFC28_2173	COG0427	acetyl-CoA hydrolase
GFC28_2175	COG0577	efflux transmembrane transporter activity
GFC28_2175	COG1136	(ABC) transporter
GFC28_2179	COG1309	transcriptional regulator
GFC28_2181	COG0501	Belongs to the peptidase M48B family
GFC28_2182	COG1131	(ABC) transporter
GFC28_2188	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFC28_2189	COG3764	Sortase (surface protein transpeptidase)
GFC28_2190	COG0745	RESPONSE REGULATOR receiver
GFC28_2190	COG2972	Histidine kinase
GFC28_2191	COG3279	Response regulator of the LytR AlgR family
GFC28_2195	COG1597	lipid kinase activity
GFC28_22	COG1234	tRNA 3'-trailer cleavage
GFC28_2200	COG2268	Band 7 protein
GFC28_2201	COG1585	Membrane protein implicated in regulation of membrane protease activity
GFC28_2203	COG5002	protein histidine kinase activity
GFC28_2207	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GFC28_2209	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFC28_2210	COG3842	ATPase activity
GFC28_2217	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GFC28_2218	COG1518	maintenance of DNA repeat elements
GFC28_222	COG1231	oxidoreductase activity
GFC28_2225	COG1174	glycine betaine transport
GFC28_2226	COG1125	glycine betaine transport
GFC28_2226	COG0517	IMP dehydrogenase activity
GFC28_2227	COG1732	Glycine betaine
GFC28_2228	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFC28_2229	COG0154	amidase activity
GFC28_223	COG1278	Cold shock
GFC28_2230	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFC28_2231	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GFC28_2237	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFC28_2238	COG0726	polysaccharide deacetylase
GFC28_2239	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFC28_2240	COG0022	dehydrogenase e1 component
GFC28_2241	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFC28_2242	COG3284	Transcriptional regulator
GFC28_2245	COG1136	(ABC) transporter
GFC28_2248	COG2197	response regulator
GFC28_2250	COG1012	belongs to the aldehyde dehydrogenase family
GFC28_2251	COG4851	CamS sex pheromone cAM373 precursor
GFC28_2252	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFC28_2254	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GFC28_2255	COG4496	protein, YerC YecD
GFC28_2256	COG1470	cell adhesion involved in biofilm formation
GFC28_2258	COG0151	Belongs to the GarS family
GFC28_226	COG1733	regulation of RNA biosynthetic process
GFC28_2260	COG0138	bifunctional purine biosynthesis protein purh
GFC28_2261	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GFC28_2262	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFC28_2263	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFC28_2264	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFC28_2265	COG0047	phosphoribosylformylglycinamidine synthase activity
GFC28_2266	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFC28_2267	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFC28_2268	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFC28_2269	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFC28_227	COG0640	Transcriptional regulator
GFC28_2270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFC28_2278	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFC28_2279	COG2252	PERMEase
GFC28_228	COG5658	integral membrane protein
GFC28_2280	COG0519	Catalyzes the synthesis of GMP from XMP
GFC28_2280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFC28_2281	COG1305	Transglutaminase-like
GFC28_2282	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GFC28_2283	COG0714	Associated with various cellular activities
GFC28_229	COG4377	Putative membrane peptidase family (DUF2324)
GFC28_2290	COG2801	Transposase and inactivated derivatives
GFC28_2293	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFC28_2301	COG3299	homolog of phage Mu protein gp47
GFC28_2302	COG3628	GPW Gp25 family protein
GFC28_2304	COG4193	domain, Protein
GFC28_2305	COG1652	LysM domain
GFC28_2306	COG5280	Phage tail tape measure protein TP901
GFC28_2306	COG3953	SLT domain
GFC28_2316	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GFC28_2318	COG2369	cell adhesion
GFC28_2319	COG5518	Phage portal protein
GFC28_232	COG0569	domain protein
GFC28_232	COG0475	glutathione-regulated potassium exporter activity
GFC28_2320	COG1783	phage Terminase large subunit
GFC28_2321	COG5484	DNA packaging
GFC28_2336	COG3723	Recombinational DNA repair protein, rece pathway
GFC28_2337	COG5377	YqaJ viral recombinase family
GFC28_234	COG2814	Major facilitator Superfamily
GFC28_235	COG0583	DNA-binding transcription factor activity
GFC28_2357	COG0582	viral genome integration into host DNA
GFC28_2359	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFC28_2360	COG1266	CAAX protease self-immunity
GFC28_2362	COG0805	protein transport
GFC28_2363	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFC28_2364	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GFC28_2365	COG0315	cyclic pyranopterin monophosphate synthase activity
GFC28_2366	COG0488	(ABC) transporter
GFC28_2367	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFC28_2368	COG0456	acetyltransferase
GFC28_2369	COG1214	PFAM Peptidase M22, glycoprotease
GFC28_2370	COG0802	atpase or kinase
GFC28_2389	COG3091	SprT-like family
GFC28_2391	COG2183	response to ionizing radiation
GFC28_2392	COG2337	Toxic component of a toxin-antitoxin (TA) module
GFC28_2393	COG0864	Transcriptional regulator
GFC28_2394	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFC28_2395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GFC28_2396	COG0736	holo-[acyl-carrier-protein] synthase activity
GFC28_2397	COG0705	Rhomboid family
GFC28_2398	COG0513	Belongs to the DEAD box helicase family
GFC28_24	COG1902	pentaerythritol trinitrate reductase activity
GFC28_2400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFC28_2401	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFC28_2402	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFC28_2403	COG0586	Pfam SNARE associated Golgi protein
GFC28_2404	COG0726	polysaccharide deacetylase
GFC28_2405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFC28_2407	COG2197	response regulator
GFC28_2415	COG3594	Acyltransferase
GFC28_2416	COG2318	DinB family
GFC28_2419	COG1971	Probably functions as a manganese efflux pump
GFC28_2420	COG0531	amino acid
GFC28_2421	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFC28_2424	COG1368	sulfuric ester hydrolase activity
GFC28_2425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GFC28_2430	COG1120	ATPase activity
GFC28_2431	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFC28_2432	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_2433	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_2434	COG2819	hydrolase of the alpha beta superfamily
GFC28_2435	COG2819	hydrolase of the alpha beta superfamily
GFC28_2436	COG0778	Nitroreductase
GFC28_2437	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_2438	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_2439	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFC28_244	COG3654	unkown
GFC28_2440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFC28_2440	COG2207	Transcriptional regulator
GFC28_2442	COG3251	PFAM MbtH domain protein
GFC28_2443	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFC28_2444	COG3433	isochorismatase activity
GFC28_2444	COG1535	isochorismatase
GFC28_2445	COG1021	2,3-dihydroxybenzoate-AMP ligase
GFC28_2446	COG1169	isochorismate synthase
GFC28_2447	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_2448	COG0351	phosphomethylpyrimidine kinase
GFC28_2455	COG2814	Major facilitator Superfamily
GFC28_2456	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFC28_2456	COG2207	Transcriptional regulator
GFC28_2457	COG0778	Nitroreductase
GFC28_2460	COG0726	polysaccharide deacetylase
GFC28_2462	COG1733	regulation of RNA biosynthetic process
GFC28_2463	COG3153	acetyltransferase
GFC28_2463	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFC28_2464	COG0456	acetyltransferase
GFC28_2467	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFC28_2471	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFC28_2472	COG2211	Major facilitator Superfamily
GFC28_2474	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFC28_2477	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFC28_2478	COG4856	YbbR-like protein
GFC28_2479	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GFC28_2480	COG5662	AntiSigma factor
GFC28_2481	COG1595	DNA-templated transcription, initiation
GFC28_25	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFC28_2500	COG0726	polysaccharide deacetylase
GFC28_2501	COG2194	sulfuric ester hydrolase activity
GFC28_2503	COG0489	protein tyrosine kinase activity
GFC28_2504	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFC28_2506	COG0457	Tetratricopeptide repeat
GFC28_2506	COG0463	Glycosyl transferase, family 2
GFC28_2508	COG0457	Tetratricopeptide repeat
GFC28_2508	COG0463	Glycosyl transferase, family 2
GFC28_2512	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFC28_2513	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFC28_2514	COG0101	tRNA pseudouridine synthase activity
GFC28_2516	COG1122	ATPase activity
GFC28_2517	COG1122	ATPase activity
GFC28_2518	COG0203	ribosomal protein L17
GFC28_2519	COG0202	RNA polymerase activity
GFC28_252	COG3290	protein histidine kinase activity
GFC28_252	COG3829	transcription factor binding
GFC28_2520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFC28_2521	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFC28_2522	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFC28_2523	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFC28_2524	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GFC28_2525	COG0024	Methionine aminopeptidase
GFC28_2526	COG0563	adenylate kinase activity
GFC28_2527	COG0201	protein transport
GFC28_2528	COG0200	Binds to the 23S rRNA
GFC28_2529	COG1841	ribosomal large subunit assembly
GFC28_2530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFC28_2531	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GFC28_2533	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFC28_2534	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFC28_2535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFC28_2536	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFC28_2537	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFC28_2538	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFC28_2539	COG0255	Belongs to the universal ribosomal protein uL29 family
GFC28_254	COG1454	alcohol dehydrogenase
GFC28_2540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFC28_2541	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFC28_2542	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFC28_2543	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFC28_2544	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFC28_2545	COG0089	rRNA binding
GFC28_2546	COG0088	Forms part of the polypeptide exit tunnel
GFC28_2547	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFC28_2548	COG0051	transcription antitermination factor activity, RNA binding
GFC28_2549	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFC28_255	COG1785	Belongs to the alkaline phosphatase family
GFC28_2550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFC28_2551	COG0049	tRNA binding
GFC28_2552	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFC28_2553	COG1358	cellular component organization or biogenesis
GFC28_2554	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFC28_2555	COG0085	RNA polymerase activity
GFC28_2556	COG2813	Specifically methylates the guanine in position
GFC28_2557	COG0222	ribosome binding
GFC28_2558	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFC28_2560	COG0081	regulation of translation
GFC28_2561	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFC28_2562	COG0250	Participates in transcription elongation, termination and antitermination
GFC28_2563	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFC28_2565	COG3688	RNA-binding protein containing a PIN domain
GFC28_2566	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFC28_2568	COG0215	cysteine-tRNA ligase activity
GFC28_2569	COG1045	serine acetyltransferase
GFC28_2570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFC28_2571	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GFC28_2572	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GFC28_2573	COG4956	integral membrane protein (PIN domain superfamily)
GFC28_2574	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GFC28_2575	COG0542	response to heat
GFC28_2576	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GFC28_2577	COG3880	PFAM UvrB UvrC protein
GFC28_259	COG3290	protein histidine kinase activity
GFC28_26	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFC28_260	COG4565	transcriptional regulatory protein
GFC28_2600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFC28_2601	COG1396	sequence-specific DNA binding
GFC28_2602	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GFC28_2603	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GFC28_2604	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFC28_2605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFC28_2606	COG0512	Glutamine amidotransferase of anthranilate synthase
GFC28_2607	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFC28_2608	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFC28_2609	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GFC28_2610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GFC28_2611	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFC28_2613	COG0037	tRNA processing
GFC28_2614	COG0515	serine threonine protein kinase
GFC28_2615	COG2304	oxidoreductase activity
GFC28_2616	COG2208	phosphoserine phosphatase activity
GFC28_2619	COG1098	S1 RNA binding domain
GFC28_2623	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFC28_2624	COG3956	TIGRFAM MazG family protein
GFC28_2625	COG2244	polysaccharide biosynthetic process
GFC28_2626	COG2002	toxin-antitoxin pair type II binding
GFC28_2627	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFC28_2629	COG0193	aminoacyl-tRNA hydrolase activity
GFC28_2630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFC28_2632	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFC28_2633	COG2088	sporulation resulting in formation of a cellular spore
GFC28_2634	COG0251	oxidation-reduction process
GFC28_2635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFC28_2636	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GFC28_2638	COG4466	Protein conserved in bacteria
GFC28_2640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFC28_2642	COG3583	domain protein
GFC28_2642	COG3584	3D domain protein
GFC28_2643	COG0084	hydrolase, TatD family'
GFC28_2645	COG2002	toxin-antitoxin pair type II binding
GFC28_2646	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFC28_2647	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GFC28_2648	COG4467	Involved in initiation control of chromosome replication
GFC28_2649	COG1774	PSP1 C-terminal conserved region
GFC28_2650	COG0470	DNA polymerase III
GFC28_2651	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFC28_2652	COG1982	Orn Lys Arg decarboxylase major
GFC28_2654	COG2801	Transposase and inactivated derivatives
GFC28_2655	COG2801	Transposase and inactivated derivatives
GFC28_266	COG0531	amino acid
GFC28_2664	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFC28_2665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GFC28_2666	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFC28_2667	COG0590	tRNA wobble adenosine to inosine editing
GFC28_2668	COG3858	chitin binding
GFC28_2668	COG1388	LysM domain
GFC28_2669	COG1428	Deoxynucleoside kinase
GFC28_2670	COG1428	Deoxynucleoside kinase
GFC28_2672	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFC28_2673	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GFC28_2674	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GFC28_2676	COG0516	GMP reductase activity
GFC28_2676	COG0517	IMP dehydrogenase activity
GFC28_268	COG0673	inositol 2-dehydrogenase activity
GFC28_2686	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFC28_2687	COG0187	DNA topoisomerase II activity
GFC28_2688	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFC28_2689	COG2501	S4 domain
GFC28_269	COG1129	ABC transporter
GFC28_2690	COG0592	DNA-directed DNA polymerase activity
GFC28_2691	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFC28_2692	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GFC28_2693	COG0594	ribonuclease P activity
GFC28_2694	COG0706	membrane insertase activity
GFC28_2695	COG1847	R3H domain protein
GFC28_2696	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFC28_2697	COG0445	tRNA wobble uridine modification
GFC28_2698	COG0357	Ribosomal RNA small subunit methyltransferase G
GFC28_2699	COG1475	DNA binding
GFC28_27	COG0300	oxidoreductase activity
GFC28_270	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFC28_2700	COG1192	Involved in chromosome partitioning
GFC28_2701	COG1475	DNA binding
GFC28_2704	COG0668	transmembrane transport
GFC28_2705	COG4481	Protein conserved in bacteria
GFC28_2706	COG0243	molybdopterin cofactor binding
GFC28_2707	COG0012	GTP binding
GFC28_2708	COG0360	Binds together with S18 to 16S ribosomal RNA
GFC28_2709	COG0629	single-stranded DNA binding
GFC28_271	COG1879	ABC-type sugar transport system periplasmic component
GFC28_2710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFC28_2711	COG4241	membrane
GFC28_2712	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GFC28_2713	COG0359	binds to the 23S rRNA
GFC28_2714	COG0305	Participates in initiation and elongation during chromosome replication
GFC28_2715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFC28_2716	COG0745	RESPONSE REGULATOR receiver
GFC28_2717	COG5002	protein histidine kinase activity
GFC28_2718	COG4863	YycH protein
GFC28_2719	COG4853	Protein conserved in bacteria
GFC28_272	COG1609	Transcriptional regulator
GFC28_2720	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFC28_2721	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFC28_2724	COG3620	sequence-specific DNA binding
GFC28_2725	COG1846	Transcriptional regulator
GFC28_2726	COG2814	Major facilitator Superfamily
GFC28_273	COG0673	inositol 2-dehydrogenase activity
GFC28_2730	COG3457	Alanine racemase
GFC28_2731	COG1929	Belongs to the glycerate kinase type-1 family
GFC28_2732	COG1115	amino acid carrier protein
GFC28_2733	COG0723	plastoquinol--plastocyanin reductase activity
GFC28_2733	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFC28_2736	COG0559	Belongs to the binding-protein-dependent transport system permease family
GFC28_2739	COG0410	ABC transporter
GFC28_2740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFC28_2742	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFC28_2744	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GFC28_2746	COG0765	amino acid transport
GFC28_2748	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFC28_2749	COG0686	Belongs to the AlaDH PNT family
GFC28_2750	COG2508	Transcriptional regulator
GFC28_2750	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GFC28_2751	COG4187	Peptidase family M20/M25/M40
GFC28_2752	COG0477	Major facilitator Superfamily
GFC28_2753	COG1216	Glycosyl transferase, family 2
GFC28_2754	COG0423	glycine-tRNA ligase activity
GFC28_2757	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFC28_276	COG3962	Belongs to the TPP enzyme family
GFC28_2760	COG2363	Small membrane protein
GFC28_2762	COG3773	Cell wall hydrolase
GFC28_2764	COG0280	phosphate acetyltransferase
GFC28_2765	COG0095	Lipoate-protein ligase
GFC28_2767	COG4844	belongs to the
GFC28_2768	COG1078	dGTPase activity
GFC28_2769	COG3465	dGTPase activity
GFC28_277	COG1082	Xylose isomerase domain protein TIM barrel
GFC28_2771	COG2252	PERMEase
GFC28_2773	COG1994	Peptidase M50
GFC28_2775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFC28_2777	COG0010	Belongs to the arginase family
GFC28_2778	COG4506	Protein conserved in bacteria
GFC28_2779	COG0018	arginyl-trna synthetase
GFC28_278	COG0191	fructose-bisphosphate aldolase activity
GFC28_2781	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFC28_2782	COG2181	nitrate reductase activity
GFC28_2782	COG0247	lactate metabolic process
GFC28_2783	COG0183	Belongs to the thiolase family
GFC28_2784	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFC28_2785	COG1960	acyl-CoA dehydrogenase activity
GFC28_2786	COG1960	acyl-CoA dehydrogenase activity
GFC28_2788	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFC28_2788	COG1703	isobutyryl-CoA mutase activity
GFC28_2788	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFC28_2789	COG3343	RNA polymerase activity
GFC28_279	COG3718	enzyme involved in inositol metabolism
GFC28_2790	COG0504	CTP synthase activity
GFC28_2791	COG4821	SIS domain
GFC28_2792	COG2204	response regulator
GFC28_2794	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFC28_2795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFC28_2796	COG1494	fructose-1,6-bisphosphatase
GFC28_2797	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GFC28_2798	COG0254	rRNA binding
GFC28_2799	COG1435	thymidine kinase activity
GFC28_2804	COG1012	belongs to the aldehyde dehydrogenase family
GFC28_2806	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFC28_2809	COG0009	L-threonylcarbamoyladenylate synthase
GFC28_2810	COG1971	Probably functions as a manganese efflux pump
GFC28_2812	COG0840	transmembrane signaling receptor activity
GFC28_2813	COG0698	ribose 5-phosphate isomerase
GFC28_2814	COG4475	Protein of unknown function (DUF436)
GFC28_2815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFC28_2816	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFC28_2819	COG0356	it plays a direct role in the translocation of protons across the membrane
GFC28_2820	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFC28_2821	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFC28_2822	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFC28_2823	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFC28_2824	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFC28_2825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFC28_2826	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFC28_2827	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFC28_2828	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFC28_2829	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFC28_2830	COG0649	NAD binding
GFC28_2831	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFC28_2833	COG0839	Belongs to the complex I subunit 6 family
GFC28_2834	COG0713	ATP synthesis coupled electron transport
GFC28_2835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFC28_2836	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFC28_2837	COG1007	ATP synthesis coupled electron transport
GFC28_2838	COG4836	Membrane
GFC28_2840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFC28_2841	COG2385	sporulation resulting in formation of a cellular spore
GFC28_2842	COG0739	heme binding
GFC28_2844	COG1609	Transcriptional regulator
GFC28_2845	COG1077	Cell shape determining protein MreB Mrl
GFC28_2846	COG4786	Flagellar basal body rod
GFC28_2847	COG4786	Flagellar basal body rod
GFC28_2849	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFC28_285	COG1201	RNA secondary structure unwinding
GFC28_2852	COG0561	phosphatase activity
GFC28_2853	COG1609	Transcriptional regulator
GFC28_2854	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GFC28_2856	COG1175	transmembrane transport
GFC28_2857	COG0395	ABC-type sugar transport system, permease component
GFC28_2860	COG1482	cell wall glycoprotein biosynthetic process
GFC28_2861	COG1609	Transcriptional regulator
GFC28_2862	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFC28_2863	COG1869	D-ribose catabolic process
GFC28_2864	COG1129	ABC transporter
GFC28_2865	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFC28_2866	COG1879	ABC-type sugar transport system periplasmic component
GFC28_2868	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GFC28_2870	COG1482	cell wall glycoprotein biosynthetic process
GFC28_2871	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFC28_2872	COG1447	Phosphotransferase system cellobiose-specific component IIA
GFC28_2873	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFC28_2874	COG2723	6-phospho-beta-galactosidase activity
GFC28_2875	COG2188	Transcriptional regulator
GFC28_2877	COG0673	inositol 2-dehydrogenase activity
GFC28_2878	COG1940	carbohydrate kinase activity
GFC28_2880	COG1309	transcriptional regulator
GFC28_2881	COG0477	Major facilitator Superfamily
GFC28_2882	COG3226	Transcriptional regulator
GFC28_2886	COG1012	belongs to the aldehyde dehydrogenase family
GFC28_2891	COG0527	aspartate kinase activity
GFC28_2893	COG3764	Sortase (surface protein transpeptidase)
GFC28_2895	COG0629	single-stranded DNA binding
GFC28_2898	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFC28_2900	COG1388	LysM domain
GFC28_2900	COG0791	NLP P60 protein
GFC28_2901	COG1316	TRANSCRIPTIONal
GFC28_2902	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GFC28_2904	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFC28_2907	COG0728	peptidoglycan biosynthetic process
GFC28_2910	COG0653	protein targeting
GFC28_2914	COG0791	NLP P60 protein
GFC28_2915	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFC28_2925	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFC28_2935	COG2336	PFAM SpoVT AbrB
GFC28_2941	COG0670	Belongs to the BI1 family
GFC28_2942	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFC28_2944	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFC28_2945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFC28_2948	COG2376	Dihydroxyacetone kinase
GFC28_2949	COG3829	transcription factor binding
GFC28_2949	COG3290	protein histidine kinase activity
GFC28_295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFC28_2950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFC28_2951	COG0583	DNA-binding transcription factor activity
GFC28_2955	COG0745	RESPONSE REGULATOR receiver
GFC28_2956	COG0642	Histidine kinase
GFC28_2957	COG1136	(ABC) transporter
GFC28_2958	COG0577	efflux transmembrane transporter activity
GFC28_2959	COG2329	Antibiotic biosynthesis monooxygenase
GFC28_2964	COG0095	Lipoate-protein ligase
GFC28_2969	COG1271	oxidase subunit
GFC28_2970	COG1294	oxidase, subunit
GFC28_2971	COG4988	ABC transporter
GFC28_2972	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GFC28_2976	COG3764	Sortase (surface protein transpeptidase)
GFC28_2980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFC28_2981	COG0726	polysaccharide deacetylase
GFC28_2982	COG4193	domain, Protein
GFC28_2983	COG1404	Belongs to the peptidase S8 family
GFC28_2986	COG0438	transferase activity, transferring glycosyl groups
GFC28_2989	COG0728	peptidoglycan biosynthetic process
GFC28_2990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFC28_2991	COG1316	TRANSCRIPTIONal
GFC28_2992	COG1739	Uncharacterized protein family UPF0029
GFC28_2993	COG4585	Histidine kinase
GFC28_2994	COG2197	response regulator
GFC28_2995	COG1307	EDD domain protein, DegV family
GFC28_2996	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GFC28_3	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFC28_3000	COG1728	Protein conserved in bacteria
GFC28_3002	COG2747	anti-sigma28 factor FlgM
GFC28_3004	COG1256	bacterial-type flagellum assembly
GFC28_3004	COG4786	Flagellar basal body rod
GFC28_3005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GFC28_3008	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GFC28_3009	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GFC28_3014	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFC28_3015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFC28_3016	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GFC28_3017	COG2089	acid synthase
GFC28_3019	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFC28_302	COG1024	Enoyl-CoA hydratase
GFC28_3020	COG1083	cytidylyl-transferase
GFC28_3021	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GFC28_3023	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GFC28_3024	COG1516	flagellar protein fliS
GFC28_303	COG0477	Major facilitator Superfamily
GFC28_3030	COG0653	protein targeting
GFC28_3031	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GFC28_3032	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFC28_3034	COG2884	Cell division ATP-binding protein ftsE
GFC28_3035	COG2177	Part of the ABC transporter FtsEX involved in
GFC28_3036	COG0791	NLP P60 protein
GFC28_3036	COG3883	PFAM NLP P60 protein
GFC28_3037	COG0450	alkyl hydroperoxide reductase
GFC28_3038	COG3634	alkyl hydroperoxide reductase activity
GFC28_3039	COG0789	Transcriptional regulator
GFC28_3040	COG2738	Putative neutral zinc metallopeptidase
GFC28_3041	COG1253	flavin adenine dinucleotide binding
GFC28_3044	COG0640	Transcriptional regulator
GFC28_3046	COG3409	Peptidoglycan-binding domain 1 protein
GFC28_3046	COG0793	Belongs to the peptidase S41A family
GFC28_3048	COG0463	Glycosyl transferase, family 2
GFC28_3053	COG3335	DDE superfamily endonuclease
GFC28_3055	COG0789	Transcriptional regulator
GFC28_3056	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFC28_3057	COG4897	Protein conserved in bacteria
GFC28_3058	COG0556	nucleotide-excision repair
GFC28_3059	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFC28_3061	COG1950	PFAM Membrane protein of
GFC28_3062	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GFC28_3063	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFC28_3064	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFC28_3065	COG0546	phosphoglycolate phosphatase activity
GFC28_3066	COG0110	maltose O-acetyltransferase activity
GFC28_3068	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GFC28_3069	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFC28_3070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFC28_3071	COG0131	Imidazoleglycerol-phosphate dehydratase
GFC28_3072	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFC28_3073	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFC28_3074	COG0107	imidazoleglycerol-phosphate synthase activity
GFC28_3075	COG0140	phosphoribosyl-ATP diphosphatase activity
GFC28_3075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFC28_3076	COG0457	Tetratricopeptide repeat
GFC28_3077	COG0492	ferredoxin-NADP+ reductase activity
GFC28_3078	COG1051	belongs to the nudix hydrolase family
GFC28_3079	COG1660	Displays ATPase and GTPase activities
GFC28_3080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GFC28_3081	COG1481	regulation of sporulation
GFC28_3082	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFC28_3083	COG0740	serine-type endopeptidase activity
GFC28_3086	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GFC28_3090	COG0126	phosphoglycerate kinase activity
GFC28_3091	COG0149	triose-phosphate isomerase activity
GFC28_3093	COG0148	phosphopyruvate hydratase activity
GFC28_3095	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFC28_3097	COG0557	exoribonuclease II activity
GFC28_3098	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFC28_310	COG0671	phosphoesterase, PA-phosphatase related
GFC28_3109	COG3328	transposase activity
GFC28_311	COG0438	transferase activity, transferring glycosyl groups
GFC28_3115	COG1131	(ABC) transporter
GFC28_3119	COG1309	transcriptional regulator
GFC28_3121	COG0492	ferredoxin-NADP+ reductase activity
GFC28_3124	COG3706	GGDEF domain
GFC28_3125	COG1132	(ABC) transporter
GFC28_3126	COG1132	(ABC) transporter
GFC28_3127	COG0778	Nitroreductase
GFC28_3137	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_314	COG2801	Transposase and inactivated derivatives
GFC28_3141	COG0463	Glycosyl transferase, family 2
GFC28_3143	COG0438	transferase activity, transferring glycosyl groups
GFC28_3146	COG0390	transport system, permease component
GFC28_315	COG4555	ABC transporter
GFC28_3150	COG5577	PFAM Coat F domain
GFC28_3152	COG0506	proline dehydrogenase activity
GFC28_3154	COG1024	Enoyl-CoA hydratase
GFC28_3154	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFC28_3155	COG0183	Belongs to the thiolase family
GFC28_3156	COG1960	acyl-CoA dehydrogenase activity
GFC28_3157	COG1393	Belongs to the ArsC family
GFC28_3158	COG0509	glycine decarboxylation via glycine cleavage system
GFC28_3159	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GFC28_3160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_3163	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFC28_3164	COG2011	ABC-type metal ion transport system permease component
GFC28_3165	COG1464	Belongs to the NlpA lipoprotein family
GFC28_3166	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFC28_3167	COG0396	ATPase activity
GFC28_3168	COG0719	Fe-S assembly protein
GFC28_3169	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFC28_3170	COG0822	iron-sulfur transferase activity
GFC28_3171	COG0719	Fe-S assembly protein
GFC28_3172	COG1801	Protein of unknown function DUF72
GFC28_3173	COG0730	response to heat
GFC28_3174	COG0737	Belongs to the 5'-nucleotidase family
GFC28_3175	COG3377	Domain of unknown function (DUF1805)
GFC28_3177	COG0739	heme binding
GFC28_3178	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFC28_318	COG2135	peptidase activity
GFC28_3181	COG4470	Protein conserved in bacteria
GFC28_3184	COG2445	Protein of unknown function DUF86
GFC28_3186	COG0647	UMP catabolic process
GFC28_3187	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GFC28_3188	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GFC28_3189	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFC28_3191	COG3328	transposase activity
GFC28_32	COG4918	Iron-sulphur cluster biosynthesis
GFC28_320	COG2814	Major facilitator Superfamily
GFC28_3204	COG3328	transposase activity
GFC28_3206	COG0460	homoserine dehydrogenase
GFC28_3207	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFC28_3208	COG0083	homoserine kinase activity
GFC28_3209	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GFC28_3210	COG4837	Protein of unknown function (DUF1462)
GFC28_3211	COG0697	spore germination
GFC28_3212	COG1252	NADH dehydrogenase
GFC28_3215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFC28_3216	COG0316	Belongs to the HesB IscA family
GFC28_3217	COG0492	ferredoxin-NADP+ reductase activity
GFC28_3218	COG1252	NADH dehydrogenase
GFC28_322	COG2011	ABC-type metal ion transport system permease component
GFC28_3222	COG3584	3D domain protein
GFC28_3223	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFC28_3225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GFC28_3226	COG1392	Phosphate transport regulator
GFC28_3227	COG0306	phosphate transporter
GFC28_3228	COG1268	BioY protein
GFC28_323	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFC28_3232	COG5018	Exonuclease
GFC28_3234	COG2032	superoxide dismutase activity
GFC28_3236	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GFC28_3238	COG1522	sequence-specific DNA binding
GFC28_3239	COG0436	Aminotransferase
GFC28_324	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFC28_3241	COG1098	S1 RNA binding domain
GFC28_3242	COG2155	Conserved Protein
GFC28_3243	COG1979	alcohol dehydrogenase
GFC28_3246	COG1396	sequence-specific DNA binding
GFC28_3249	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFC28_325	COG0254	rRNA binding
GFC28_3252	COG1405	negative regulation of cell septum assembly
GFC28_3252	COG3012	SEC-C Motif Domain Protein
GFC28_3253	COG2814	Major facilitator Superfamily
GFC28_3254	COG1247	-acetyltransferase
GFC28_3256	COG3227	Zinc metalloprotease (Elastase)
GFC28_3257	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFC28_3258	COG0840	transmembrane signaling receptor activity
GFC28_3259	COG1285	pathogenesis
GFC28_3261	COG0697	spore germination
GFC28_327	COG1024	Enoyl-CoA hydratase
GFC28_3280	COG1230	cation diffusion facilitator family transporter
GFC28_3284	COG0297	glycogen (starch) synthase activity
GFC28_3286	COG0058	SHG alpha-glucan phosphorylase activity
GFC28_3288	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GFC28_3289	COG1575	Belongs to the MenA family. Type 1 subfamily
GFC28_3290	COG1169	isochorismate synthase
GFC28_3291	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFC28_3292	COG0596	Alpha beta hydrolase
GFC28_3293	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GFC28_3294	COG0318	PFAM AMP-dependent synthetase and ligase
GFC28_3300	COG1294	oxidase, subunit
GFC28_3301	COG1271	oxidase subunit
GFC28_3303	COG1854	S-ribosylhomocysteine lyase activity
GFC28_3304	COG0783	Belongs to the Dps family
GFC28_3305	COG4824	toxin secretion phage lysis holin
GFC28_3307	COG5609	conserved protein (DUF2294)
GFC28_3308	COG0494	nUDIX hydrolase
GFC28_3309	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFC28_3310	COG1116	anion transmembrane transporter activity
GFC28_3311	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFC28_3312	COG1506	peptidase
GFC28_3314	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFC28_3315	COG3002	Belongs to the UPF0753 family
GFC28_3316	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GFC28_3317	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFC28_3318	COG4990	cell redox homeostasis
GFC28_3319	COG0367	asparagine synthase
GFC28_332	COG2151	metal-sulfur cluster biosynthetic enzyme
GFC28_3320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFC28_3321	COG2267	carboxylic ester hydrolase activity
GFC28_3323	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GFC28_3324	COG1242	4 iron, 4 sulfur cluster binding
GFC28_3327	COG2814	Major facilitator Superfamily
GFC28_3329	COG0495	leucyl-tRNA aminoacylation
GFC28_3330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFC28_3335	COG2081	HI0933 family
GFC28_3336	COG2244	polysaccharide biosynthetic process
GFC28_3338	COG1187	pseudouridine synthase activity
GFC28_3339	COG1349	DNA-binding transcription factor activity
GFC28_3340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFC28_3343	COG1380	Effector of murein hydrolase LrgA
GFC28_3344	COG1346	cytolysis
GFC28_3346	COG1523	belongs to the glycosyl hydrolase 13 family
GFC28_3348	COG0510	thiamine kinase activity
GFC28_3349	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFC28_335	COG1024	Enoyl-CoA hydratase
GFC28_3350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFC28_3352	COG1363	Peptidase, m42
GFC28_3353	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GFC28_3354	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_3355	COG4848	Belongs to the UPF0354 family
GFC28_3356	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFC28_3357	COG1674	ftsk spoiiie
GFC28_3357	COG1674	ftsk spoiiie
GFC28_3358	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GFC28_3359	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFC28_3360	COG2309	aminopeptidase activity
GFC28_3363	COG3118	belongs to the thioredoxin family
GFC28_3364	COG0849	cell division
GFC28_3365	COG1605	Chorismate mutase
GFC28_3365	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFC28_3367	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFC28_3368	COG0517	IMP dehydrogenase activity
GFC28_3369	COG0454	-acetyltransferase
GFC28_3370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFC28_3373	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFC28_3374	COG2199	diguanylate cyclase activity
GFC28_3374	COG2203	Gaf domain
GFC28_3375	COG1956	GAF domain-containing protein
GFC28_3376	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GFC28_3377	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GFC28_3378	COG1104	cysteine desulfurase activity
GFC28_3379	COG0301	tRNA thio-modification
GFC28_338	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GFC28_3381	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFC28_3382	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFC28_3383	COG0616	signal peptide processing
GFC28_3384	COG1714	RDD family
GFC28_3386	COG3874	Sporulation protein YtfJ
GFC28_3387	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GFC28_3388	COG0827	DNA restriction-modification system
GFC28_3389	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFC28_339	COG1069	ribulokinase activity
GFC28_3390	COG0521	Mo-molybdopterin cofactor biosynthetic process
GFC28_3391	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFC28_3393	COG0137	argininosuccinate synthase activity
GFC28_3394	COG0165	Argininosuccinate lyase
GFC28_3395	COG0589	response to stress
GFC28_3397	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_3399	COG0006	proline dipeptidase activity
GFC28_340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFC28_3400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFC28_3401	COG4109	DRTGG domain
GFC28_3403	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFC28_3406	COG0587	DNA-directed DNA polymerase activity
GFC28_3407	COG0281	malic enzyme
GFC28_3408	COG1725	Transcriptional regulator
GFC28_3409	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GFC28_341	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFC28_3410	COG0825	malonyl-CoA metabolic process
GFC28_3411	COG0205	6-phosphofructokinase activity
GFC28_3414	COG0628	permease
GFC28_3415	COG2707	UPF0756 membrane protein
GFC28_3416	COG0372	Belongs to the citrate synthase family
GFC28_3417	COG0538	isocitrate dehydrogenase activity
GFC28_3418	COG0039	L-malate dehydrogenase activity
GFC28_342	COG1129	ABC transporter
GFC28_3420	COG0745	RESPONSE REGULATOR receiver
GFC28_3421	COG5002	protein histidine kinase activity
GFC28_3423	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFC28_3424	COG0237	dephospho-CoA kinase activity
GFC28_3425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFC28_3426	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GFC28_3428	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFC28_3429	COG3611	Membrane attachment protein
GFC28_343	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFC28_3430	COG1484	DNA-dependent DNA replication
GFC28_3432	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFC28_3434	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFC28_3435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFC28_3438	COG1363	Peptidase, m42
GFC28_3439	COG2226	methyltransferase
GFC28_3442	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFC28_3444	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFC28_3445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFC28_3445	COG0072	phenylalanine-tRNA ligase activity
GFC28_3446	COG1131	(ABC) transporter
GFC28_3447	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GFC28_3448	COG1846	Transcriptional regulator
GFC28_3449	COG1033	growth of symbiont in host cell
GFC28_3449	COG2409	Drug exporters of the RND superfamily
GFC28_345	COG1879	ABC-type sugar transport system periplasmic component
GFC28_3450	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFC28_3451	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GFC28_3452	COG1286	toxin biosynthetic process
GFC28_3453	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GFC28_3453	COG1796	DNA polymerase
GFC28_3454	COG1193	negative regulation of DNA recombination
GFC28_3455	COG3766	membrane
GFC28_3456	COG0318	PFAM AMP-dependent synthetase and ligase
GFC28_3457	COG1309	transcriptional regulator
GFC28_3458	COG1024	Enoyl-CoA hydratase
GFC28_3459	COG2086	electron transfer activity
GFC28_346	COG3347	Dehydrogenase
GFC28_346	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_3460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFC28_3461	COG3118	belongs to the thioredoxin family
GFC28_3462	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFC28_3463	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFC28_3465	COG1215	transferase activity, transferring glycosyl groups
GFC28_3469	COG0322	excinuclease ABC activity
GFC28_347	COG1070	Carbohydrate kinase
GFC28_3472	COG1719	4-vinyl reductase, 4VR
GFC28_3473	COG2009	succinate dehydrogenase
GFC28_3474	COG1053	succinate dehydrogenase
GFC28_3475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GFC28_3476	COG2197	response regulator
GFC28_3477	COG1846	Transcriptional regulator
GFC28_3478	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFC28_3479	COG5401	PFAM Sporulation and spore germination
GFC28_348	COG4806	L-rhamnose isomerase
GFC28_3480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GFC28_3481	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFC28_3482	COG0622	Phosphoesterase
GFC28_3484	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFC28_3485	COG0028	Belongs to the TPP enzyme family
GFC28_3486	COG0440	acetolactate synthase activity
GFC28_3487	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFC28_3488	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFC28_3489	COG0473	3-isopropylmalate dehydrogenase activity
GFC28_349	COG1349	DNA-binding transcription factor activity
GFC28_3490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFC28_3491	COG0066	3-isopropylmalate dehydratase activity
GFC28_3493	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFC28_3494	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFC28_3495	COG1067	ATP-dependent peptidase activity
GFC28_3495	COG0470	DNA polymerase III
GFC28_3496	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFC28_3497	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GFC28_35	COG0667	Aldo Keto reductase
GFC28_350	COG0656	L-ascorbic acid biosynthetic process
GFC28_3500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFC28_3501	COG0181	hydroxymethylbilane synthase activity
GFC28_3502	COG1587	Uroporphyrinogen-III synthase
GFC28_3503	COG0113	porphobilinogen synthase activity
GFC28_3504	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFC28_3505	COG1388	LysM domain
GFC28_3505	COG1388	LysM domain
GFC28_3508	COG0525	valine-tRNA ligase activity
GFC28_3509	COG0285	dihydrofolate synthase activity
GFC28_351	COG1272	protein, Hemolysin III
GFC28_3518	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFC28_352	COG1063	alcohol dehydrogenase
GFC28_3522	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GFC28_3528	COG0424	maF-like protein
GFC28_3529	COG2003	Belongs to the UPF0758 family
GFC28_353	COG0010	Belongs to the arginase family
GFC28_3530	COG1077	Cell shape determining protein MreB Mrl
GFC28_3531	COG1792	Involved in formation and maintenance of cell shape
GFC28_3532	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GFC28_3533	COG0850	regulation of cytokinetic process
GFC28_3534	COG2894	cell division
GFC28_3535	COG0739	heme binding
GFC28_3536	COG1994	Peptidase M50
GFC28_3537	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFC28_3538	COG2868	ribosomal protein
GFC28_3539	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFC28_3540	COG3290	protein histidine kinase activity
GFC28_3541	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFC28_3542	COG4492	Belongs to the UPF0735 family
GFC28_3543	COG0077	Prephenate dehydratase
GFC28_3548	COG0789	Transcriptional regulator
GFC28_3549	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFC28_355	COG2207	Transcriptional regulator
GFC28_355	COG1609	Transcriptional regulator
GFC28_3552	COG1968	undecaprenyl-diphosphatase activity
GFC28_3553	COG1827	regulation of RNA biosynthetic process
GFC28_3554	COG1104	cysteine desulfurase activity
GFC28_3555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GFC28_3556	COG0157	Belongs to the NadC ModD family
GFC28_3557	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFC28_3558	COG1388	LysM domain
GFC28_356	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GFC28_3560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFC28_3562	COG0217	transcriptional regulatory protein
GFC28_3565	COG0632	four-way junction helicase activity
GFC28_3566	COG2255	four-way junction helicase activity
GFC28_3568	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFC28_3569	COG0343	queuine tRNA-ribosyltransferase activity
GFC28_357	COG1228	amidohydrolase
GFC28_3570	COG1862	Preprotein translocase
GFC28_3572	COG2244	polysaccharide biosynthetic process
GFC28_3574	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFC28_3574	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFC28_3575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GFC28_3576	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFC28_3576	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFC28_3577	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFC28_3578	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFC28_3579	COG1490	D-aminoacyl-tRNA deacylase activity
GFC28_3580	COG4991	sh3 domain protein
GFC28_3580	COG3103	Sh3 type 3 domain protein
GFC28_3580	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFC28_3582	COG0124	histidyl-tRNA synthetase
GFC28_3583	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFC28_3584	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GFC28_3585	COG1309	transcriptional regulator
GFC28_3586	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFC28_3587	COG2364	Membrane
GFC28_3588	COG1959	2 iron, 2 sulfur cluster binding
GFC28_3589	COG1104	cysteine desulfurase activity
GFC28_359	COG1970	mechanosensitive ion channel activity
GFC28_3590	COG0482	sulfurtransferase activity
GFC28_3592	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFC28_3595	COG0628	permease
GFC28_3596	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFC28_3597	COG4472	Bacterial protein of unknown function (DUF965)
GFC28_3598	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFC28_3599	COG3906	Belongs to the UPF0473 family
GFC28_36	COG0494	nUDIX hydrolase
GFC28_3600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFC28_3604	COG0572	uridine kinase
GFC28_3605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFC28_3606	COG0768	penicillin binding
GFC28_3609	COG2226	methyltransferase
GFC28_3610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFC28_3611	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFC28_3612	COG0626	cystathionine gamma-synthase activity
GFC28_3614	COG2508	Transcriptional regulator
GFC28_3615	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFC28_3616	COG1024	Enoyl-CoA hydratase
GFC28_3617	COG2814	Major facilitator Superfamily
GFC28_3619	COG0318	PFAM AMP-dependent synthetase and ligase
GFC28_3620	COG0183	Belongs to the thiolase family
GFC28_3625	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFC28_363	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_3631	COG0586	Pfam SNARE associated Golgi protein
GFC28_3634	COG1360	Flagellar Motor Protein
GFC28_3635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GFC28_3636	COG1183	phosphatidylcholine synthase activity
GFC28_3637	COG0688	phosphatidylethanolamine metabolic process
GFC28_3639	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GFC28_3640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFC28_3641	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFC28_3642	COG1534	Rna-binding protein
GFC28_3643	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFC28_3644	COG1713	HD superfamily hydrolase involved in NAD metabolism
GFC28_3645	COG0799	negative regulation of ribosome biogenesis
GFC28_3646	COG2226	methyltransferase
GFC28_3647	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFC28_3648	COG1596	polysaccharide export
GFC28_3648	COG1555	photosystem II stabilization
GFC28_3649	COG2131	deaminase
GFC28_365	COG1802	Transcriptional regulator
GFC28_3650	COG2333	competence protein COMEC
GFC28_3650	COG0658	competence protein
GFC28_3652	COG1466	dna polymerase III delta subunit
GFC28_3653	COG0268	Binds directly to 16S ribosomal RNA
GFC28_3654	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GFC28_3655	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFC28_3657	COG0481	GTPase activity
GFC28_3658	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFC28_3659	COG1420	regulation of RNA biosynthetic process
GFC28_366	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFC28_3660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFC28_3661	COG0443	Heat shock 70 kDa protein
GFC28_3662	COG0484	heat shock protein binding
GFC28_3663	COG2264	protein methyltransferase activity
GFC28_3664	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFC28_3665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFC28_3666	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFC28_3667	COG1283	sodium-dependent phosphate transmembrane transporter activity
GFC28_3668	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFC28_3669	COG1610	YqeY-like protein
GFC28_367	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFC28_3672	COG1702	phosphate starvation-inducible protein PhoH
GFC28_3673	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFC28_3674	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GFC28_3675	COG0295	cytidine deaminase activity
GFC28_3676	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFC28_3678	COG1381	Involved in DNA repair and RecF pathway recombination
GFC28_3679	COG0517	IMP dehydrogenase activity
GFC28_368	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GFC28_3680	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GFC28_3682	COG1671	Belongs to the UPF0178 family
GFC28_3684	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFC28_3686	COG2010	Cytochrome c
GFC28_3687	COG2384	SAM-dependent methyltransferase
GFC28_3688	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFC28_3689	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GFC28_3691	COG0513	Belongs to the DEAD box helicase family
GFC28_3692	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GFC28_3694	COG1121	(ABC) transporter
GFC28_3695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFC28_3696	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GFC28_3697	COG0735	belongs to the Fur family
GFC28_3698	COG4709	membrane
GFC28_3699	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GFC28_37	COG1379	DNA repair
GFC28_3701	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFC28_3702	COG0573	inorganic phosphate transmembrane transporter activity
GFC28_3703	COG0581	inorganic phosphate transmembrane transporter activity
GFC28_3704	COG3973	AAA domain
GFC28_3705	COG5521	maltodextrose utilization protein MalA
GFC28_3706	COG0840	transmembrane signaling receptor activity
GFC28_3708	COG0477	Major facilitator Superfamily
GFC28_371	COG0626	cystathionine gamma-synthase activity
GFC28_3711	COG0704	Plays a role in the regulation of phosphate uptake
GFC28_3714	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFC28_3715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFC28_3716	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFC28_372	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_3720	COG0705	Rhomboid family
GFC28_3720	COG0457	Tetratricopeptide repeat
GFC28_3722	COG0697	spore germination
GFC28_3723	COG4483	Protein conserved in bacteria
GFC28_3724	COG1940	carbohydrate kinase activity
GFC28_3725	COG2368	4-hydroxyphenylacetate
GFC28_3726	COG1368	sulfuric ester hydrolase activity
GFC28_3728	COG0011	TIGRFAM Protein of
GFC28_3731	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFC28_3735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFC28_3736	COG1459	type II secretion system
GFC28_3737	COG4537	Required for transformation and DNA binding
GFC28_3745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFC28_3746	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFC28_3747	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFC28_3749	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFC28_3750	COG0095	Lipoate-protein ligase
GFC28_3755	COG3858	chitin binding
GFC28_3755	COG1388	LysM domain
GFC28_3755	COG1388	LysM domain
GFC28_3755	COG3858	chitin binding
GFC28_3757	COG1321	iron dependent repressor
GFC28_3758	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFC28_3760	COG3872	metal-dependent enzyme
GFC28_3762	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GFC28_3763	COG0006	proline dipeptidase activity
GFC28_3764	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFC28_3766	COG3854	ATPases associated with a variety of cellular activities
GFC28_3774	COG0511	ligase activity, forming carbon-carbon bonds
GFC28_3775	COG0439	Biotin carboxylase
GFC28_3776	COG1302	Protein conserved in bacteria
GFC28_3777	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFC28_3778	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFC28_3779	COG1570	exodeoxyribonuclease VII activity
GFC28_3780	COG1722	exodeoxyribonuclease VII activity
GFC28_3782	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFC28_3783	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GFC28_3784	COG1438	arginine binding
GFC28_3785	COG0497	DNA recombination
GFC28_3786	COG0750	zinc metalloprotease
GFC28_3789	COG0492	ferredoxin-NADP+ reductase activity
GFC28_3790	COG3093	addiction module antidote protein HigA
GFC28_3791	COG0584	glycerophosphoryl diester phosphodiesterase
GFC28_3793	COG3829	transcription factor binding
GFC28_3793	COG3290	protein histidine kinase activity
GFC28_3794	COG0280	phosphate acetyltransferase
GFC28_3796	COG3426	butyrate kinase activity
GFC28_3797	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFC28_3798	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFC28_3799	COG0022	dehydrogenase e1 component
GFC28_38	COG1300	Membrane
GFC28_380	COG1063	alcohol dehydrogenase
GFC28_3800	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFC28_3804	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFC28_3805	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFC28_3805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFC28_3806	COG1703	isobutyryl-CoA mutase activity
GFC28_3807	COG3620	sequence-specific DNA binding
GFC28_381	COG1063	alcohol dehydrogenase
GFC28_382	COG3711	transcriptional antiterminator
GFC28_385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFC28_385	COG1522	sequence-specific DNA binding
GFC28_386	COG2313	pseudouridylate synthase activity
GFC28_39	COG0735	belongs to the Fur family
GFC28_391	COG1657	PFAM Prenyltransferase squalene oxidase
GFC28_392	COG4989	oxidoreductase activity
GFC28_394	COG3711	transcriptional antiterminator
GFC28_397	COG0084	hydrolase, TatD family'
GFC28_398	COG2323	membrane
GFC28_399	COG0129	dihydroxy-acid dehydratase activity
GFC28_4	COG0765	amino acid transport
GFC28_401	COG0561	phosphatase activity
GFC28_402	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFC28_405	COG0840	transmembrane signaling receptor activity
GFC28_406	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFC28_407	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFC28_41	COG4974	Belongs to the 'phage' integrase family
GFC28_410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFC28_411	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GFC28_412	COG3396	Phenylacetate-CoA oxygenase
GFC28_415	COG2151	metal-sulfur cluster biosynthetic enzyme
GFC28_417	COG1024	Enoyl-CoA hydratase
GFC28_418	COG1024	Enoyl-CoA hydratase
GFC28_420	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFC28_421	COG0183	Belongs to the thiolase family
GFC28_422	COG1024	Enoyl-CoA hydratase
GFC28_423	COG3327	negative regulation of DNA-templated transcription, initiation
GFC28_429	COG0022	dehydrogenase e1 component
GFC28_430	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFC28_437	COG3853	Toxic anion resistance protein (TelA)
GFC28_441	COG0004	ammonium transporteR
GFC28_445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFC28_446	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_447	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_448	COG1120	ATPase activity
GFC28_452	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFC28_453	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFC28_454	COG1918	ferrous iron import across plasma membrane
GFC28_454	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFC28_455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFC28_456	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFC28_457	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFC28_459	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_46	COG1686	Belongs to the peptidase S11 family
GFC28_461	COG0318	PFAM AMP-dependent synthetase and ligase
GFC28_462	COG1960	acyl-CoA dehydrogenase activity
GFC28_468	COG0456	acetyltransferase
GFC28_468	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GFC28_47	COG1366	Belongs to the anti-sigma-factor antagonist family
GFC28_472	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GFC28_472	COG0456	acetyltransferase
GFC28_475	COG3011	Protein conserved in bacteria
GFC28_477	COG1388	LysM domain
GFC28_477	COG0791	NLP P60 protein
GFC28_478	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFC28_478	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GFC28_479	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GFC28_48	COG2172	sigma factor antagonist activity
GFC28_480	COG1984	allophanate hydrolase subunit 2
GFC28_481	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GFC28_482	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GFC28_483	COG3383	formate dehydrogenase (NAD+) activity
GFC28_485	COG0463	Glycosyl transferase, family 2
GFC28_487	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GFC28_488	COG0351	phosphomethylpyrimidine kinase
GFC28_489	COG0352	thiamine-phosphate diphosphorylase activity
GFC28_490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFC28_491	COG0833	amino acid
GFC28_492	COG3104	oligopeptide transport
GFC28_493	COG1525	nuclease
GFC28_494	COG3852	Histidine kinase
GFC28_496	COG0745	RESPONSE REGULATOR receiver
GFC28_497	COG5002	protein histidine kinase activity
GFC28_498	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFC28_499	COG1111	helicase
GFC28_499	COG1205	dead DEAH box helicase
GFC28_5	COG1126	abc transporter atp-binding protein
GFC28_500	COG3359	exonuclease
GFC28_503	COG4474	Belongs to the UPF0398 family
GFC28_507	COG4474	Belongs to the UPF0398 family
GFC28_508	COG3599	regulation of cell shape
GFC28_510	COG0116	Belongs to the methyltransferase superfamily
GFC28_515	COG1595	DNA-templated transcription, initiation
GFC28_522	COG2801	Transposase and inactivated derivatives
GFC28_523	COG1191	sigma factor activity
GFC28_529	COG1199	ATP-dependent helicase activity
GFC28_53	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFC28_530	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GFC28_531	COG3209	COG3209 Rhs family protein
GFC28_550	COG1231	oxidoreductase activity
GFC28_551	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFC28_552	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GFC28_554	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFC28_555	COG2233	PERMEase
GFC28_556	COG0217	transcriptional regulatory protein
GFC28_557	COG3424	synthase
GFC28_558	COG1755	Isoprenylcysteine carboxyl methyltransferase
GFC28_559	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GFC28_56	COG0697	spore germination
GFC28_563	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_567	COG0824	Thioesterase
GFC28_569	COG2050	protein possibly involved in aromatic compounds catabolism
GFC28_570	COG4841	protein insertion into membrane
GFC28_574	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFC28_575	COG0492	ferredoxin-NADP+ reductase activity
GFC28_576	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFC28_577	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GFC28_578	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GFC28_579	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFC28_58	COG4086	secreted protein
GFC28_580	COG0456	acetyltransferase
GFC28_581	COG1509	lysine 2,3-aminomutase activity
GFC28_583	COG4479	Belongs to the UPF0346 family
GFC28_587	COG0515	serine threonine protein kinase
GFC28_588	COG4326	sporulation control protein
GFC28_59	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFC28_594	COG1876	peptidase activity
GFC28_596	COG2226	methyltransferase
GFC28_597	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GFC28_598	COG0598	Magnesium transport protein CorA
GFC28_599	COG2962	Rard protein
GFC28_6	COG4129	membrane
GFC28_60	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFC28_60	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFC28_602	COG0534	Mate efflux family protein
GFC28_603	COG3852	Histidine kinase
GFC28_604	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFC28_606	COG2814	Major facilitator Superfamily
GFC28_61	COG0307	riboflavin synthase, alpha
GFC28_610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFC28_614	COG0655	NAD(P)H dehydrogenase (quinone) activity
GFC28_615	COG1309	transcriptional regulator
GFC28_617	COG1960	acyl-CoA dehydrogenase activity
GFC28_618	COG0318	PFAM AMP-dependent synthetase and ligase
GFC28_619	COG0439	Biotin carboxylase
GFC28_62	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFC28_62	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFC28_620	COG0511	ligase activity, forming carbon-carbon bonds
GFC28_621	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFC28_622	COG1024	Enoyl-CoA hydratase
GFC28_623	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFC28_625	COG1566	PFAM secretion protein HlyD family protein
GFC28_626	COG2814	Major facilitator Superfamily
GFC28_63	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFC28_632	COG0697	spore germination
GFC28_633	COG0697	spore germination
GFC28_635	COG1131	(ABC) transporter
GFC28_640	COG2205	protein histidine kinase activity
GFC28_641	COG1725	Transcriptional regulator
GFC28_645	COG1131	(ABC) transporter
GFC28_648	COG2318	DinB family
GFC28_65	COG1547	Domain of unknown function (DUF309)
GFC28_651	COG1132	(ABC) transporter
GFC28_652	COG1132	(ABC) transporter
GFC28_653	COG2258	MOSC domain
GFC28_657	COG0730	response to heat
GFC28_659	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFC28_66	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GFC28_661	COG1609	Transcriptional regulator
GFC28_662	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GFC28_663	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GFC28_665	COG2755	lipolytic protein G-D-S-L family
GFC28_666	COG1131	(ABC) transporter
GFC28_667	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GFC28_668	COG0494	nUDIX hydrolase
GFC28_669	COG0697	spore germination
GFC28_67	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GFC28_671	COG3832	glyoxalase III activity
GFC28_672	COG0640	Transcriptional regulator
GFC28_674	COG1937	Protein conserved in bacteria
GFC28_675	COG2217	Heavy metal translocating P-type atpase
GFC28_676	COG2217	Heavy metal translocating P-type atpase
GFC28_677	COG0693	protein deglycase activity
GFC28_678	COG0697	spore germination
GFC28_680	COG2814	Major facilitator Superfamily
GFC28_681	COG0789	Transcriptional regulator
GFC28_682	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFC28_684	COG0567	Dehydrogenase, E1 component
GFC28_685	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFC28_686	COG0531	amino acid
GFC28_688	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFC28_689	COG0110	maltose O-acetyltransferase activity
GFC28_690	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFC28_691	COG0583	DNA-binding transcription factor activity
GFC28_692	COG0697	spore germination
GFC28_696	COG1132	(ABC) transporter
GFC28_697	COG1132	(ABC) transporter
GFC28_7	COG1376	ErfK ybiS ycfS ynhG family protein
GFC28_70	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFC28_709	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GFC28_71	COG1686	Belongs to the peptidase S11 family
GFC28_710	COG0363	glucosamine-6-phosphate deaminase activity
GFC28_712	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFC28_712	COG1263	PTS System
GFC28_713	COG4821	SIS domain
GFC28_714	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GFC28_715	COG0840	transmembrane signaling receptor activity
GFC28_719	COG1119	ATPase activity
GFC28_72	COG2715	membrane protein required for spore maturation
GFC28_725	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_726	COG0551	DNA topoisomerase type I activity
GFC28_726	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFC28_728	COG0778	Nitroreductase
GFC28_729	COG2259	Doxx family
GFC28_73	COG0700	Nucleoside recognition
GFC28_738	COG1388	LysM domain
GFC28_739	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFC28_74	COG1187	pseudouridine synthase activity
GFC28_742	COG3959	Transketolase, thiamine diphosphate binding domain
GFC28_743	COG3958	Transketolase
GFC28_745	COG2031	fatty acid transporter
GFC28_746	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFC28_747	COG1279	arginine transmembrane transporter activity
GFC28_75	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFC28_751	COG1132	(ABC) transporter
GFC28_752	COG1132	(ABC) transporter
GFC28_755	COG3403	YqcI/YcgG family
GFC28_756	COG1280	lysine exporter protein (LysE YggA)
GFC28_757	COG0789	Transcriptional regulator
GFC28_759	COG1522	sequence-specific DNA binding
GFC28_76	COG1333	cytochrome c biogenesis protein
GFC28_761	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GFC28_762	COG4149	molybdate abc transporter
GFC28_763	COG1910	domain protein
GFC28_764	COG0725	ABC transporter, periplasmic molybdate-binding protein
GFC28_765	COG0243	molybdopterin cofactor binding
GFC28_769	COG2814	Major facilitator Superfamily
GFC28_77	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFC28_772	COG1309	transcriptional regulator
GFC28_776	COG0640	Transcriptional regulator
GFC28_777	COG0798	PFAM Bile acid sodium symporter
GFC28_778	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFC28_78	COG0745	RESPONSE REGULATOR receiver
GFC28_786	COG3340	Belongs to the peptidase S51 family
GFC28_788	COG0456	acetyltransferase
GFC28_79	COG5002	protein histidine kinase activity
GFC28_794	COG2404	hydrolase activity, acting on ester bonds
GFC28_795	COG4548	von Willebrand factor, type A
GFC28_796	COG0714	Associated with various cellular activities
GFC28_798	COG0788	formyltetrahydrofolate deformylase activity
GFC28_799	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFC28_799	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFC28_800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFC28_800	COG1017	nitric oxide dioxygenase activity
GFC28_801	COG1959	2 iron, 2 sulfur cluster binding
GFC28_803	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GFC28_804	COG1960	acyl-CoA dehydrogenase activity
GFC28_807	COG1757	Na H antiporter
GFC28_808	COG2188	Transcriptional regulator
GFC28_809	COG0366	Alpha amylase catalytic
GFC28_810	COG1263	PTS System
GFC28_810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFC28_811	COG2190	(PTS) system
GFC28_812	COG2190	(PTS) system
GFC28_814	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFC28_815	COG0187	DNA topoisomerase II activity
GFC28_816	COG1832	CoA-binding protein
GFC28_819	COG3689	TIGRFAM TIGR03943 family protein
GFC28_82	COG1132	(ABC) transporter
GFC28_820	COG0701	Predicted permease
GFC28_821	COG0523	cobalamin synthesis protein
GFC28_822	COG3314	Sporulation integral membrane protein YlbJ
GFC28_838	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GFC28_839	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFC28_84	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFC28_841	COG3647	Membrane
GFC28_842	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GFC28_843	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFC28_843	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GFC28_845	COG2755	lipolytic protein G-D-S-L family
GFC28_846	COG1999	signal sequence binding
GFC28_847	COG1307	EDD domain protein, DegV family
GFC28_849	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFC28_85	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFC28_851	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFC28_852	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFC28_854	COG0436	Aminotransferase
GFC28_856	COG2521	methyltransferase
GFC28_856	COG2136	Putative SAM-dependent methyltransferase
GFC28_86	COG1120	ATPase activity
GFC28_860	COG1413	lyase activity
GFC28_861	COG1418	mRNA catabolic process
GFC28_862	COG0386	Belongs to the glutathione peroxidase family
GFC28_865	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GFC28_868	COG2226	methyltransferase
GFC28_869	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GFC28_87	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GFC28_871	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GFC28_872	COG1492	cobalamin metabolic process
GFC28_878	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GFC28_88	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFC28_883	COG1122	ATPase activity
GFC28_885	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GFC28_886	COG0310	cobalt ion transport
GFC28_893	COG1164	Oligoendopeptidase f
GFC28_894	COG0706	membrane insertase activity
GFC28_898	COG1587	Uroporphyrinogen-III synthase
GFC28_9	COG0346	lactoylglutathione lyase activity
GFC28_90	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GFC28_900	COG4191	Histidine kinase
GFC28_901	COG0024	Methionine aminopeptidase
GFC28_903	COG3689	TIGRFAM TIGR03943 family protein
GFC28_904	COG0701	Predicted permease
GFC28_905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFC28_905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFC28_905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFC28_906	COG1105	Belongs to the carbohydrate kinase PfkB family
GFC28_907	COG1349	DNA-binding transcription factor activity
GFC28_908	COG2199	diguanylate cyclase activity
GFC28_908	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GFC28_910	COG2356	endonuclease I
GFC28_911	COG1757	Na H antiporter
GFC28_912	COG0789	Transcriptional regulator
GFC28_915	COG3279	Response regulator of the LytR AlgR family
GFC28_916	COG3275	phosphorelay sensor kinase activity
GFC28_918	COG1024	Enoyl-CoA hydratase
GFC28_922	COG1309	transcriptional regulator
GFC28_923	COG1070	Carbohydrate kinase
GFC28_924	COG2115	Belongs to the xylose isomerase family
GFC28_925	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GFC28_928	COG5578	integral membrane protein
GFC28_929	COG1028	Short-chain dehydrogenase reductase Sdr
GFC28_93	COG2096	Adenosyltransferase
GFC28_931	COG1904	glucuronate isomerase
GFC28_932	COG1802	Transcriptional regulator
GFC28_936	COG0395	ABC-type sugar transport system, permease component
GFC28_937	COG4209	transmembrane transport
GFC28_943	COG1175	transmembrane transport
GFC28_944	COG1653	transport
GFC28_945	COG4753	response regulator
GFC28_945	COG2207	Transcriptional regulator
GFC28_946	COG2972	Histidine kinase
GFC28_948	COG0667	Aldo Keto reductase
GFC28_951	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFC28_952	COG1129	ABC transporter
GFC28_953	COG4213	ABC transporter substrate-binding protein
GFC28_956	COG1069	ribulokinase activity
GFC28_959	COG4214	carbohydrate transport
GFC28_96	COG1595	DNA-templated transcription, initiation
GFC28_961	COG4213	ABC transporter substrate-binding protein
GFC28_962	COG2207	Transcriptional regulator
GFC28_962	COG4753	response regulator
GFC28_963	COG2972	Histidine kinase
GFC28_965	COG2207	Transcriptional regulator
GFC28_965	COG3708	Transcriptional regulator
GFC28_967	COG1012	belongs to the aldehyde dehydrogenase family
GFC28_968	COG0840	transmembrane signaling receptor activity
GFC28_969	COG0840	transmembrane signaling receptor activity
GFC28_971	COG4844	belongs to the
GFC28_975	COG0765	amino acid transport
GFC28_976	COG0765	amino acid transport
GFC28_977	COG4191	Histidine kinase
GFC28_978	COG0784	Response regulator, receiver
GFC28_979	COG1280	lysine exporter protein (LysE YggA)
GFC28_98	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GFC28_982	COG3844	kynureninase activity
GFC28_983	COG1309	transcriptional regulator
GFC28_984	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFC28_986	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFC28_987	COG1012	belongs to the aldehyde dehydrogenase family
GFC28_988	COG2508	Transcriptional regulator
GFC28_99	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFC28_991	COG0167	dihydroorotate dehydrogenase activity
GFC28_991	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GFC28_997	COG0493	'glutamate synthase
GFC28_998	COG0069	glutamate synthase activity
GFC28_998	COG0067	glutamate synthase
GFC28_998	COG0070	glutamate synthase
GFC28_999	COG0583	DNA-binding transcription factor activity