locus-tag class description GFC29_10 ENOG410787A Pts system, glucitol sorbitol-specific GFC29_1001 ENOG4107QX3 carboxylase GFC29_1002 ENOG4105E39 Enoyl-CoA hydratase GFC29_1003 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GFC29_1004 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GFC29_1005 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GFC29_1006 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_1007 ENOG4105C1G acyl-Coa dehydrogenase GFC29_1010 ENOG4108WS4 fmn reductase GFC29_1014 ENOG4105C7B Threonine dehydratase GFC29_1020 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GFC29_1021 ENOG4105BZU Histidine kinase GFC29_1022 ENOG4107QMU Mate efflux family protein GFC29_1025 ENOG4105FR1 rard protein GFC29_1026 ENOG4105D7N magnesium and cobalt transport protein CorA GFC29_1030 ENOG4108VXD carboxy-peptidase GFC29_1035 ENOG4106Z5R GFC29_1036 ENOG4108N23 SpoOM-related protein GFC29_1037 ENOG4105G0J serine threonine protein kinase GFC29_1041 ENOG4105VSD UPF0346 protein GFC29_1043 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GFC29_1044 ENOG4108TSC N-acetyltransferase GFC29_1045 ENOG4107S4Y M20 DapE family protein YgeY GFC29_1048 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GFC29_1049 ENOG4105C3M thioredoxin reductase GFC29_1050 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GFC29_1054 ENOG4105W8X HesB YadR YfhF-family protein GFC29_1055 ENOG4105KA0 thioesterase Superfamily protein GFC29_1056 ENOG4105MI2 GFC29_1058 ENOG41067CD Small, acid-soluble spore protein Tlp GFC29_1059 ENOG41075ZD Small, acid-soluble spore protein N GFC29_1061 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC29_1062 ENOG4105KHC sulfurtransferase GFC29_1065 ENOG410890F Dynamin family GFC29_1067 ENOG41065KQ synthase GFC29_1068 ENOG4105CDY transcriptional regulatory protein GFC29_1069 ENOG4105C2W permease GFC29_107 ENOG4105CQB FAD linked oxidase domain protein GFC29_1070 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GFC29_1072 ENOG4105NAA Cytochrome C oxidase, subunit II GFC29_1073 ENOG4107RQ2 Cytochrome c oxidase, subunit I GFC29_108 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC29_109 ENOG4105CQB FAD linked oxidase domain protein GFC29_1093 ENOG4105CNA YD repeat protein GFC29_1094 ENOG4105CTD carboxy-peptidase GFC29_1095 ENOG4105DVT helicase GFC29_11 ENOG4105DZY Pts system, glucitol sorbitol-specific GFC29_110 ENOG4105C82 Malate synthase GFC29_1101 ENOG4106DF4 Sigma-70, region 4 GFC29_1102 ENOG4105DQ6 Transposase GFC29_1109 ENOG4108AEY RNA polymerase sigma factor GFC29_111 ENOG4105ERH Fumarylacetoacetate hydrolase GFC29_1114 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GFC29_1115 ENOG4105BZU Histidine kinase GFC29_1116 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) GFC29_1117 ENOG4108UKS UPF0398 protein GFC29_112 ENOG4107HP6 Transcriptional regulator GFC29_1121 ENOG4108UKS UPF0398 protein GFC29_1124 ENOG4107X2U Inherit from COG: Exonuclease-like protein GFC29_1125 ENOG4108I5C dEAD DEAH box helicase GFC29_1126 ENOG4105C6T cysteine synthase GFC29_1127 ENOG4105BZU Histidine kinase GFC29_1128 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC29_113 ENOG4107S91 Sodium hydrogen exchanger GFC29_1130 ENOG4105BZU Histidine kinase GFC29_1131 ENOG4107Y9E nuclease GFC29_1132 ENOG4105DUX Transporter GFC29_1133 ENOG4108IQI permease GFC29_1134 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GFC29_1135 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GFC29_1136 ENOG4105DWF phosphomethylpyrimidine kinase GFC29_1137 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GFC29_114 ENOG4105NCW Trka-c domain protein GFC29_1141 ENOG4108HIZ formate dehydrogenase alpha subunit GFC29_1142 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GFC29_1143 ENOG4105E7W lamb ycsf family protein GFC29_1145 ENOG4105P4J Allophanate hydrolase, subunit 1 GFC29_1146 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GFC29_1149 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GFC29_115 ENOG4105DWK Membrane GFC29_1152 ENOG4105RHY Pfam:UPF0157 GFC29_1156 ENOG4105RHY Pfam:UPF0157 GFC29_1160 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GFC29_1162 ENOG4105CSU acyl-Coa dehydrogenase GFC29_1163 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_1165 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GFC29_1167 ENOG4105NAE bifunctional deaminase-reductase domain protein GFC29_1168 ENOG4105NAE bifunctional deaminase-reductase domain protein GFC29_1169 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GFC29_1170 ENOG4105CE1 Ferrous iron transport protein b GFC29_1171 ENOG4105CE1 Ferrous iron transport protein b GFC29_1172 ENOG4105CE1 Ferrous iron transport protein b GFC29_1173 ENOG4105CVJ phosphoglycerate mutase GFC29_1174 ENOG4105BZU Histidine kinase GFC29_1176 ENOG4105E0A ABC, transporter GFC29_1177 ENOG4108IHU transport system permease protein GFC29_1178 ENOG4105DQ5 transport system permease protein GFC29_1179 ENOG4108MES Periplasmic binding protein GFC29_1187 ENOG4105CDW Resistance protein GFC29_119 ENOG4105DTQ mandelate racemase muconate lactonizing GFC29_1194 ENOG4105C7S Dehydrogenase GFC29_1195 ENOG4105CPP Dehydrogenase, E1 component GFC29_1199 ENOG4105EA8 2-Nitropropane dioxygenase GFC29_12 ENOG4105VI0 Pts system, glucitol sorbitol-specific GFC29_1200 ENOG4108Z0R Transferase GFC29_1201 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein GFC29_1202 ENOG4105E39 Enoyl-CoA hydratase GFC29_1203 ENOG4105CHU acetyl-coa acetyltransferase GFC29_1204 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC29_1205 ENOG4105C26 Dehydrogenase GFC29_1206 ENOG4105CGU Enoyl-CoA hydratase GFC29_1207 ENOG4105E39 Enoyl-CoA hydratase GFC29_1209 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GFC29_1212 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GFC29_1213 ENOG4105DZS Phenylacetate-CoA ligase GFC29_1214 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GFC29_1216 ENOG4105C28 cystathionine GFC29_1217 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GFC29_1218 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GFC29_1219 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_1223 ENOG4105J7I hydrolase GFC29_1225 ENOG4105C01 Dihydroxy-acid dehydratase GFC29_1226 ENOG4105H67 Protein of unknown function (DUF421) GFC29_1227 ENOG4108RE7 deoxyribonuclease GFC29_123 ENOG4105CUB amino acid GFC29_1230 ENOG4105ETD TRANSCRIPTIONal GFC29_1232 ENOG4107QM2 Aldo Keto reductase GFC29_1233 ENOG4105EWU Squalene--hopene cyclase GFC29_1238 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GFC29_1239 ENOG4105DD7 kinase (PfkB family GFC29_1243 ENOG4105CPQ Dehydrogenase GFC29_1244 ENOG4105CPQ Dehydrogenase GFC29_1246 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GFC29_125 ENOG410681C small acid-soluble spore protein GFC29_1252 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GFC29_1253 ENOG4105C28 cystathionine GFC29_1254 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GFC29_1256 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GFC29_1257 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GFC29_1258 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GFC29_1259 ENOG4105DRR Transcriptional regulator, GntR family GFC29_126 ENOG4107KJX Transcriptional regulator GFC29_1261 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GFC29_1265 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GFC29_1266 ENOG4105DWD nucleoside recognition domain protein GFC29_1267 ENOG4105CI2 imidazolone-5-propionate hydrolase GFC29_1268 ENOG4105CGP Urocanate hydratase GFC29_1269 ENOG4105T16 Transcriptional regulator (AraC family) GFC29_1271 ENOG41088SP formiminoglutamate hydrolase GFC29_1273 ENOG4108UT2 hemolysin iii GFC29_1275 ENOG4105E98 transcriptional regulator DeoR family GFC29_1276 ENOG4105DKG l-rhamnose isomerase GFC29_1277 ENOG4105DET Rhamnulokinase GFC29_1279 ENOG4105D4B ABC, transporter GFC29_128 ENOG4108JE9 extracellular solute-binding protein family 1 GFC29_1281 ENOG4105CNN ABC, transporter GFC29_1282 ENOG4105C2J ABC transporter GFC29_1283 ENOG4108RVA ribokinase GFC29_1284 ENOG4105DJV ribulose-phosphate 3-epimerase GFC29_1285 ENOG4105EF1 ribulokinase GFC29_1286 ENOG4105CPN adenine deaminase GFC29_1289 ENOG4105E39 Enoyl-CoA hydratase GFC29_1292 ENOG4105VG1 fes assembly suf system protein GFC29_1297 ENOG4105E39 Enoyl-CoA hydratase GFC29_1299 ENOG4105NRA 50s ribosomal protein l31 type b GFC29_13 ENOG4107RHR regulatoR GFC29_130 ENOG4105DRS transport system, permease GFC29_1300 ENOG4105WDJ 50S ribosomal protein L33 GFC29_1301 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GFC29_1302 ENOG4108UMI ABC transporter, permease GFC29_1303 ENOG4105D01 (LipO)protein GFC29_1304 ENOG4105D94 Major Facilitator Superfamily GFC29_1306 ENOG4108RAV Conserved protein GFC29_1309 ENOG4108IUW ABC transporter GFC29_1310 ENOG4105DQ6 Transposase GFC29_1313 ENOG4105BZF Glycosyl transferase (Group 1 GFC29_1314 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GFC29_1321 ENOG4105CSH Transporter GFC29_1322 ENOG4105E39 Enoyl-CoA hydratase GFC29_1329 ENOG4105XRQ Xanthine dehydrogenase accessory factor GFC29_133 ENOG4105E2A Dehydrogenase GFC29_1330 ENOG4107XVH Transcriptional regulator GFC29_1339 ENOG4107QRT dEAD DEAH box helicase GFC29_1345 ENOG4105DH8 myo-inositol catabolism GFC29_1346 ENOG4105D2N Aldolase GFC29_1347 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GFC29_1348 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GFC29_1351 ENOG4105CK5 oxidoreductase GFC29_1352 ENOG4105ETE Transcriptional regulator (LacI family GFC29_1353 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GFC29_1354 ENOG4105CNN ABC, transporter GFC29_1355 ENOG4105C2J ABC transporter GFC29_1356 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GFC29_1358 ENOG4107R7I amino acid GFC29_1364 ENOG4108MRH transcriptional regulatory protein GFC29_1365 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GFC29_1369 ENOG4105G6Z alkaline phosphatase GFC29_1370 ENOG4105C0A alcohol dehydrogenase GFC29_1372 ENOG4108JUB Transcriptional regulator GFC29_138 ENOG4105BZU Histidine kinase GFC29_1380 ENOG41086VY Fic/DOC family GFC29_1389 ENOG4106P55 Transcriptional regulator GFC29_139 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GFC29_1390 ENOG4105CZM Major Facilitator GFC29_1395 ENOG41090T1 Membrane GFC29_1397 ENOG41082BM Transcriptional regulator, arsr family GFC29_1398 ENOG4105KVH Transcriptional regulator GFC29_14 ENOG4107RUY (E1 component), alpha subunit GFC29_1401 ENOG4105VEQ Cold shock protein GFC29_141 ENOG4108HWV )-transporter GFC29_1416 ENOG4105BZU Histidine kinase GFC29_1418 ENOG4105BZU Histidine kinase GFC29_142 ENOG4105C2J ABC transporter GFC29_1420 ENOG4105MYT Heat shock protein GFC29_1422 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase GFC29_1423 ENOG4105CMR udp-glucose 4-epimerase GFC29_1424 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GFC29_1425 ENOG4105EU9 GFC29_1427 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GFC29_1429 ENOG4105GR3 Histidine kinase GFC29_143 ENOG4105FCA ABC transporter periplasmic-binding protein YphF GFC29_1430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC29_1433 ENOG4106DDH Sporulation-specific SASP protein GFC29_1438 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GFC29_1439 ENOG4105BZ4 penicillin-binding protein GFC29_144 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GFC29_1441 ENOG4105CSM endonuclease III GFC29_1443 ENOG4105C5S asparaginyl-tRNA synthetase GFC29_1446 ENOG4105YAC GFC29_1447 ENOG4105DVT helicase GFC29_1448 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GFC29_1449 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GFC29_145 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GFC29_1450 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GFC29_1452 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GFC29_1453 ENOG4105CPK Glycosyl transferase (Group 1 GFC29_1454 ENOG4105FJR Lmbe family GFC29_1455 ENOG4108Z5K methylglyoxal synthase GFC29_1456 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GFC29_1457 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GFC29_1458 ENOG4108JYZ YitT family GFC29_146 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GFC29_1461 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit GFC29_1462 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GFC29_1463 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GFC29_1466 ENOG41068YB TPR repeat-containing protein GFC29_1468 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GFC29_1470 ENOG4105CIH Imidazole acetol-phosphate transaminase GFC29_1471 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GFC29_1473 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GFC29_1474 ENOG4105DK0 Indole-3-glycerol phosphate synthase GFC29_1475 ENOG4108I0Q anthranilate phosphoribosyltransferase GFC29_1477 ENOG4105KHN chorismate mutase GFC29_1478 ENOG4105D49 3-dehydroquinate synthase GFC29_1479 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GFC29_148 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GFC29_1480 ENOG4105BZU Histidine kinase GFC29_1481 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GFC29_1483 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GFC29_1485 ENOG4105WP2 Tryptophan RNA-binding attenuator protein GFC29_1486 ENOG4105EUJ GTP cyclohydrolase i GFC29_1488 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GFC29_149 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) GFC29_1491 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GFC29_1492 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GFC29_1496 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GFC29_1497 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GFC29_1498 ENOG4105F6E Acyl-transferase GFC29_1499 ENOG4105CAT Cytidine monophosphate kinase GFC29_15 ENOG4105CPP Dehydrogenase, E1 component GFC29_150 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GFC29_1502 ENOG4105MSI germination protein ypeb GFC29_1503 ENOG4105F0V Cell wall hydrolase GFC29_1504 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) GFC29_1506 ENOG41067SE Tetr family transcriptional regulator GFC29_1509 ENOG4105Y38 Kinase-associated protein B GFC29_151 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GFC29_1510 ENOG4105HDK L-asparaginase GFC29_1511 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GFC29_1513 ENOG4108S6Z Negative regulator of genetic competence GFC29_1514 ENOG4107RGJ metallophosphoesterase GFC29_1518 ENOG4105WEF catalase GFC29_152 ENOG41090MY MarR family Transcriptional regulator GFC29_1521 ENOG4105I7S Abortive infection protein GFC29_1522 ENOG4105C9U ATP-dependent DNA helicase RecQ GFC29_1526 ENOG4108JQ1 Dehydrogenase GFC29_1527 ENOG4107RVV histidinol phosphate phosphatase, hisj family GFC29_153 ENOG4105D5Q Arginine ornithine antiporter GFC29_1532 ENOG4108WBT adenosyltransferase GFC29_1535 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GFC29_1537 ENOG4107QZB decarboxylase GFC29_1538 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GFC29_1539 ENOG4105E0A ABC, transporter GFC29_1540 ENOG4105EHG Permease protein GFC29_1541 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GFC29_1542 ENOG4108QCI YvbH-like oligomerisation region GFC29_1543 ENOG4105BZ1 (ABC) transporter GFC29_1546 ENOG4105BZU Histidine kinase GFC29_1547 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC29_1548 ENOG4105CRE cytochrome C GFC29_1549 ENOG4107TWT Cytochrome c biogenesis protein GFC29_155 ENOG4105CJ1 ABC, transporter GFC29_1550 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC29_1551 ENOG4105FE9 pseudouridine synthase GFC29_1553 ENOG4108JIC nucleoside recognition domain protein GFC29_1554 ENOG4105DZ1 carboxypeptidase GFC29_1555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GFC29_1558 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GFC29_1559 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GFC29_1562 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GFC29_1563 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GFC29_1564 ENOG4108R6K riboflavin synthase, subunit alpha GFC29_1565 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GFC29_1566 ENOG4107ZE5 PPIases accelerate the folding of proteins GFC29_1567 ENOG4105PTM secreted protein GFC29_1570 ENOG4105G6R Stage v sporulation protein ae GFC29_1572 ENOG4105CZ3 stage V sporulation protein ad GFC29_1573 ENOG41090VF Stage v sporulation protein ac GFC29_1576 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC29_1577 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GFC29_1578 ENOG41082AN stage II sporulation protein GFC29_1579 ENOG4105DZ1 carboxypeptidase GFC29_158 ENOG4105C32 Amino acid ABC transporter (Permease) GFC29_1584 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC29_1586 ENOG4105I3K Ferric uptake regulator, Fur family GFC29_1587 ENOG4105MZ9 stage II sporulation protein m GFC29_1589 ENOG4108YZ4 nudix hydrolase GFC29_1590 ENOG4105CPC Aldo Keto reductase GFC29_1593 ENOG4106HZJ GFC29_1598 ENOG4108IXY short-chain dehydrogenase reductase GFC29_1599 ENOG41069FQ Metallo-beta-lactamase superfamily GFC29_16 ENOG4105C7S Dehydrogenase GFC29_160 ENOG4105C0Z ABC transporter GFC29_1600 ENOG4105II7 pyrroline-5-carboxylate reductase GFC29_1601 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GFC29_1603 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GFC29_1604 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GFC29_1605 ENOG4107XCH Cyclase family GFC29_1608 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GFC29_161 ENOG4108IV0 ABC, transporter GFC29_1612 ENOG4108V3W Chemotaxis protein, CheW GFC29_1613 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GFC29_1615 ENOG4108HNZ carboxyl transferase GFC29_1616 ENOG4108ZVT methylmalonyl-coA epimerase GFC29_1618 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GFC29_1619 ENOG4108QEG Membrane GFC29_1620 ENOG4105CDA abc transporter atp-binding protein GFC29_1621 ENOG4105E5Q amino acid AbC transporter GFC29_1622 ENOG4108HW3 (ABC) transporter GFC29_1623 ENOG4108Y6J UPF0403 protein GFC29_1626 ENOG41067QW Transcriptional regulator GFC29_1627 ENOG4105DJT lAO AO transport system ATPase GFC29_1628 ENOG4105D5P Methylmalonyl-coA mutase GFC29_1629 ENOG4105CMN Methylmalonyl-coA mutase GFC29_1633 ENOG4105C7S Dehydrogenase GFC29_1634 ENOG4105CPP Dehydrogenase, E1 component GFC29_1637 ENOG4105CKM Branched-chain carboxylic acid kinase GFC29_1640 ENOG4108JUB Transcriptional regulator GFC29_1641 ENOG4106CCJ Protein of unknown function (DUF2627) GFC29_1642 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GFC29_1644 ENOG4105C3M thioredoxin reductase GFC29_1647 ENOG4105S1Z Stage IV sporulation protein B GFC29_1648 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GFC29_1649 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GFC29_1650 ENOG4105DX0 Hemolysin A GFC29_1651 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GFC29_1653 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GFC29_1654 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GFC29_1655 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GFC29_1656 ENOG4105M7K Involved in the transcription termination process (By similarity) GFC29_1657 ENOG4108ZSR alkaline shock protein GFC29_1658 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GFC29_166 ENOG4108K88 Membrane GFC29_1662 ENOG410644B Stage III sporulation protein af GFC29_1664 ENOG4105KQ4 Stage iii sporulation protein ad GFC29_1665 ENOG4108CQH stage III sporulation protein AC GFC29_1666 ENOG4105KR5 Stage iii sporulation protein GFC29_1667 ENOG4105CD2 stage iii sporulation protein aa GFC29_1669 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GFC29_1670 ENOG4105DC7 peptidase M24 GFC29_1671 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GFC29_1673 ENOG4105CBJ Metal-dependent enzyme GFC29_1676 ENOG4105KST dependent repressor GFC29_1678 ENOG4105VRS hydrolase family 18 GFC29_1678 ENOG4105VRS hydrolase family 18 GFC29_1683 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GFC29_1684 ENOG4105WZW rhodanese family GFC29_1686 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GFC29_1687 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GFC29_1688 ENOG4105C0D helicase GFC29_1696 ENOG4106855 Competence protein GFC29_170 ENOG4108B31 Spore germination protein GFC29_1702 ENOG4105C5X domain protein GFC29_1707 ENOG4105E0M Sulfatase GFC29_171 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GFC29_1713 ENOG4107ZXI Rhomboid family GFC29_1717 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GFC29_1718 ENOG4105WDJ 50S ribosomal protein L33 GFC29_172 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase GFC29_1722 ENOG4108UTW Plays a role in the regulation of phosphate uptake GFC29_1723 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GFC29_1724 ENOG4107RF6 penicillin-binding protein GFC29_1727 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_1729 ENOG4105EEM helicase GFC29_173 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GFC29_1730 ENOG4105E2Z phosphate ABC transporter (Permease GFC29_1731 ENOG4105C8U phosphate abc transporter GFC29_1732 ENOG4105CVA phosphate GFC29_1734 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GFC29_1735 ENOG41063Y9 GFC29_1736 ENOG4105N80 Ferric uptake regulator, Fur family GFC29_1737 ENOG4108U5J '-nucleotidase GFC29_1738 ENOG4105FAV ABC, transporter GFC29_1739 ENOG4105FDK ABC transporter GFC29_1741 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GFC29_1744 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GFC29_1745 ENOG4105EGD dinuclear metal center protein, YbgI family GFC29_1749 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC29_175 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GFC29_1751 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 GFC29_1753 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GFC29_1755 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GFC29_1757 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GFC29_1758 ENOG4105KG3 cytidine deaminase GFC29_1759 ENOG4107YR5 Diacylglycerol kinase GFC29_176 ENOG4105K4T epimerase GFC29_1760 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GFC29_1761 ENOG4105C9A Phoh family GFC29_1763 ENOG41068P3 sporulation protein YqfC GFC29_1764 ENOG4105KTH gatB Yqey GFC29_1765 ENOG4105VCC 30S ribosomal protein S21 GFC29_1767 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GFC29_1768 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GFC29_1769 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GFC29_1770 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GFC29_1771 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GFC29_1772 ENOG4105CFG Acts as a chaperone (By similarity) GFC29_1773 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GFC29_1774 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GFC29_1775 ENOG4105CSA Coproporphyrinogen iii oxidase GFC29_1776 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GFC29_1778 ENOG4108ZRV stage ii sporulation protein p GFC29_1779 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) GFC29_178 ENOG4105F0V Cell wall hydrolase GFC29_1780 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GFC29_1781 ENOG4105TQK DNA polymerase iii, delta' subunit GFC29_1783 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GFC29_1784 ENOG4108UK2 deaminase GFC29_1785 ENOG4105KQC Competence protein GFC29_1787 ENOG4105DXX methyltransferase GFC29_1789 ENOG4108WF2 Metal Dependent Phosphohydrolase GFC29_1790 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GFC29_1791 ENOG410812S Rna-binding protein GFC29_1792 ENOG4105E2X shikimate dehydrogenase GFC29_1793 ENOG4105CQW ribosome biogenesis GTPase YqeH GFC29_1794 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GFC29_1796 ENOG4105DJ4 phosphatidylserine decarboxylase GFC29_1797 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GFC29_1798 ENOG4105E14 MotA TolQ exbB proton channel GFC29_1799 ENOG4105ER2 Ompa motb domain protein GFC29_18 ENOG4107RHR regulatoR GFC29_1800 ENOG4108REF Sporulation integral membrane protein ytvi GFC29_1802 ENOG4107T5V SNARE associated Golgi GFC29_1804 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC29_1808 ENOG4105ERH Fumarylacetoacetate hydrolase GFC29_1813 ENOG4105CHU acetyl-coa acetyltransferase GFC29_1814 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_1816 ENOG4105D2S major facilitator superfamily GFC29_1817 ENOG4105E39 Enoyl-CoA hydratase GFC29_1818 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC29_1819 ENOG4105G9B Transcriptional regulator GFC29_1821 ENOG4105C28 cystathionine GFC29_1823 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GFC29_1824 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GFC29_1828 ENOG4107XRG penicillin-binding protein GFC29_1829 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GFC29_1830 ENOG4105DBI uridine monophosphokinase GFC29_1831 ENOG4105CFP Peptidase U32 GFC29_1832 ENOG4105XYU peptidase (U32 family) GFC29_1833 ENOG4108VQJ O-methyltransferase GFC29_1834 ENOG4105HHA aminodeoxychorismate lyase GFC29_1835 ENOG4105VPH UPF0473 protein GFC29_1836 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GFC29_1837 ENOG4105VBH UPF0297 protein GFC29_1838 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GFC29_1839 ENOG4105C02 permease GFC29_1841 ENOG41060CR GFC29_1842 ENOG4105C7H Helicase, RecD TraA family GFC29_1844 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GFC29_1845 ENOG4105C3J Cysteine desulfurase GFC29_1848 ENOG4105D1H recombination factor protein RarA GFC29_1849 ENOG41067SE Tetr family transcriptional regulator GFC29_185 ENOG4105BZU Histidine kinase GFC29_1850 ENOG4105CUZ uba thif-type nad fad binding protein GFC29_1851 ENOG4105C9M aspartyl-trna synthetase GFC29_1852 ENOG4105CUT histidyl-tRNA synthetase GFC29_1854 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC29_1855 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GFC29_1856 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GFC29_1857 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GFC29_1858 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GFC29_1859 ENOG41076HS cation diffusion facilitator family transporter GFC29_1860 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GFC29_1862 ENOG4105CKP Polysaccharide Biosynthesis Protein GFC29_1863 ENOG4105NAP GFC29_1864 ENOG4105VIE preprotein translocase, subunit YajC GFC29_1865 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GFC29_1866 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GFC29_1867 ENOG41061AI Protein of unknown function (DUF2905) GFC29_1868 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GFC29_1869 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GFC29_1872 ENOG4105CDY transcriptional regulatory protein GFC29_1874 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GFC29_1876 ENOG4106678 morphogenetic protein associated with SpoVID GFC29_1877 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GFC29_1878 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GFC29_1879 ENOG4108IYU L-aspartate oxidase GFC29_1882 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GFC29_1885 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GFC29_1886 ENOG4105V75 Transcriptional regulator GFC29_1891 ENOG4105CQC Prephenate dehydratase GFC29_1892 ENOG41090I5 UPF0735 ACT domain-containing protein GFC29_1893 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GFC29_1895 ENOG4105K46 50S ribosomal protein l27 GFC29_1896 ENOG4105X36 (ribosomal) protein GFC29_1897 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GFC29_1900 ENOG4107QMS site-determining protein GFC29_1901 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GFC29_1902 ENOG4105YHC Rod shape-determining protein MreD GFC29_1903 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GFC29_1904 ENOG4105DFF Rod shape-determining protein mreb GFC29_1905 ENOG4105W5Q DNA repair protein (RadC GFC29_1906 ENOG4108Z03 MAF-like protein GFC29_1912 ENOG4106A3R peptidase GFC29_1915 ENOG4105CZX twitching motility protein GFC29_1916 ENOG4107QHF type ii secretion system protein e GFC29_192 ENOG4107RWR Sodium hydrogen exchanger GFC29_1925 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GFC29_1926 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GFC29_1929 ENOG41068KH stage VI sporulation protein D GFC29_1929 ENOG41068KH stage VI sporulation protein D GFC29_193 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GFC29_1930 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GFC29_1931 ENOG4105D52 delta-aminolevulinic acid dehydratase GFC29_1933 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GFC29_1935 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GFC29_1937 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GFC29_1938 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GFC29_1939 ENOG4108IUQ atp-dependent protease GFC29_1940 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GFC29_1941 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GFC29_1943 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GFC29_1944 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GFC29_1945 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GFC29_1946 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GFC29_1947 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GFC29_1948 ENOG4108ZP8 Acetolactate synthase small subunit GFC29_1949 ENOG4105C7K acetolactate synthase GFC29_195 ENOG4105CID antiterminator GFC29_1950 ENOG4105CM2 brancheD-chain amino acid aminotransferase GFC29_1952 ENOG4105M59 Phosphodiesterase, mj0936 family GFC29_1953 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GFC29_1954 ENOG4108FK2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GFC29_1955 ENOG4108XJQ germination protein GFC29_1956 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GFC29_1957 ENOG41067TZ transcriptional regulator, MarR family GFC29_1958 ENOG4105PFC Transcriptional regulator GFC29_1959 ENOG4105E33 succinate dehydrogenase GFC29_1961 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GFC29_1965 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GFC29_1969 ENOG4105C3Q Glycosyl transferase, family 2 GFC29_1971 ENOG4105C1B dTDP-glucose 4-6-dehydratase GFC29_1972 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GFC29_1973 ENOG4105K63 Thioredoxin GFC29_1974 ENOG4105C10 Electron transfer flavoprotein GFC29_1975 ENOG4105BZJ Electron transfer flavoprotein GFC29_1976 ENOG41060WC Enoyl-CoA hydratase GFC29_1977 ENOG4107Z3H Transcriptional regulator, TetR family GFC29_1978 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_1980 ENOG4105C98 muts2 protein GFC29_1981 ENOG4105DCG PHP domain protein GFC29_1983 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GFC29_1984 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GFC29_1985 ENOG4105EYF MMPL domain protein GFC29_1987 ENOG4108TU7 Inherit from COG: (ABC) transporter GFC29_1988 ENOG4105CJ1 ABC, transporter GFC29_1989 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GFC29_199 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GFC29_1990 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GFC29_1992 ENOG4108RWN rrna methyltransferase GFC29_1993 ENOG41067MF small acid-soluble spore protein GFC29_1995 ENOG4108D32 Methyltransferase GFC29_1996 ENOG4105CN9 Peptidase m42 family protein GFC29_1999 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GFC29_20 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GFC29_200 ENOG4105CHR reductase GFC29_2000 ENOG4105VJV 50s ribosomal protein L35 GFC29_2002 ENOG4105C22 threonyL-tRNA synthetase GFC29_2003 ENOG4108TDW sporulation protein YtxC GFC29_2006 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GFC29_2008 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GFC29_2009 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GFC29_201 ENOG4105YB8 TM2 domain containing protein GFC29_2010 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GFC29_2011 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GFC29_2013 ENOG4105BZU Histidine kinase GFC29_2014 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GFC29_2016 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GFC29_2017 ENOG4108HMX isocitrate dehydrogenase (NADP) GFC29_2018 ENOG4105BZN citrate synthase GFC29_2019 ENOG4108VMM UPF0756 membrane protein GFC29_202 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GFC29_2020 ENOG4108REF Sporulation integral membrane protein ytvi GFC29_2023 ENOG4105CTQ phosphohexokinase GFC29_2024 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GFC29_2025 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GFC29_2026 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GFC29_2027 ENOG4105C6K Malic enzyme GFC29_2028 ENOG4105C0B DNA polymerase III (alpha subunit) GFC29_2029 ENOG4105VV2 GFC29_203 ENOG4105CHM Aminotransferase GFC29_2031 ENOG4105SFS phosphoesterase RecJ domain protein GFC29_2034 ENOG4105E8R UPF0173 metal-dependent hydrolase GFC29_2035 ENOG4105DC7 peptidase M24 GFC29_2039 ENOG4107YZX Universal stress protein GFC29_2040 ENOG4105CH7 arginosuccinase GFC29_2041 ENOG4105CDH Citrulline--aspartate ligase GFC29_2044 ENOG4105EPU Molybdenum cofactor synthesis domain protein GFC29_2045 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GFC29_2047 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GFC29_2048 ENOG4105KBJ sporulation protein ytfj GFC29_205 ENOG4105D7N magnesium and cobalt transport protein CorA GFC29_2050 ENOG4105VK3 rdd domain containing protein GFC29_2051 ENOG4105D07 Signal peptide peptidase, SppA GFC29_2052 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GFC29_2053 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GFC29_2055 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GFC29_2057 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) GFC29_2058 ENOG4108W76 histidinol phosphate phosphatase hisj family GFC29_2060 ENOG4105BZU Histidine kinase GFC29_2061 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GFC29_2065 ENOG4105F1V Acetoin utilization protein GFC29_2066 ENOG4105W87 Cbs domain GFC29_2067 ENOG4105DGU Histone deacetylase GFC29_2068 ENOG4105ETE Transcriptional regulator (LacI family GFC29_2069 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GFC29_2070 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GFC29_2074 ENOG4105C88 aminopeptidase GFC29_2075 ENOG4105DFU Cell wall formation (By similarity) GFC29_2076 ENOG4105DAP Nicotinate phosphoribosyltransferase GFC29_2078 ENOG4108VDD TRNA binding domain protein GFC29_2079 ENOG4108NKM UPF0354 protein GFC29_208 ENOG4108HGU Histidine kinase GFC29_2081 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GFC29_2084 ENOG4105C8F Beta-lactamase domain protein GFC29_2085 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GFC29_2086 ENOG4108V15 phosphotransferase enzyme family GFC29_2088 ENOG4108IUM Glycogen debranching enzyme GFC29_2090 ENOG41067MG lrgb family GFC29_2094 ENOG4107QSE Dipeptidase GFC29_2095 ENOG4105YW5 deoR family transcriptional regulator GFC29_2099 ENOG4105CBX hi0933 family GFC29_21 ENOG4105DT3 PTS system, galactitol-specific IIc component GFC29_210 ENOG4107R88 Chemotaxis protein (CheV) GFC29_2104 ENOG41085GJ domain protein GFC29_2105 ENOG4105C8T Leucyl-tRNA synthetase GFC29_2107 ENOG410605W Major Facilitator GFC29_211 ENOG4105UIN GFC29_2110 ENOG4105N5T Radical SAM Protein GFC29_2113 ENOG4105E8V Alpha Beta Hydrolase Fold protein GFC29_2114 ENOG4108Z0R Transferase GFC29_2115 ENOG4105CAQ asparagine synthetase GFC29_2117 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GFC29_2118 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GFC29_2119 ENOG4105EVH UPF0753 protein GFC29_212 ENOG4107R33 ppx gppa phosphatase GFC29_2120 ENOG4108TWJ NADH dehydrogenase subunit 5 GFC29_2123 ENOG4105D2X ABC transporter substrate-binding protein GFC29_2125 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GFC29_2127 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GFC29_2129 ENOG4105XSJ toxin secretion phage lysis holin GFC29_213 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GFC29_2130 ENOG4108RMU ferritin dps family protein GFC29_2131 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GFC29_2140 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_2141 ENOG4108IPT Naphthoate synthase GFC29_2142 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GFC29_2143 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GFC29_2144 ENOG4105E4F Isochorismate synthase GFC29_2145 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GFC29_215 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GFC29_2150 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GFC29_2154 ENOG4105PGM cation diffusion facilitator family transporter GFC29_217 ENOG4105EPM Diguanylate phosphodiesterase GFC29_2175 ENOG4105KT7 mgtC SapB transporter GFC29_2176 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_2177 ENOG4105CPF Cell wall formation (By similarity) GFC29_2178 ENOG4105D4Y metalloprotease GFC29_2180 ENOG4107TCE N-acetyltransferase GFC29_2182 ENOG41060AI SEC-C motif GFC29_2183 ENOG4106GRI small acid-soluble spore protein H GFC29_2185 ENOG4107PBV potassium channel GFC29_219 ENOG4107IN1 Protein of unknown function (DUF1797) GFC29_2191 ENOG4107QW4 alcohol dehydrogenase GFC29_2192 ENOG4105WG9 Conserved Protein GFC29_2195 ENOG4105CHM Aminotransferase GFC29_2196 ENOG4108ZB6 transcriptional regulator AsnC family GFC29_2198 ENOG4105C87 Aminotransferase class I and II GFC29_22 ENOG4105IIP Membrane GFC29_2200 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GFC29_2207 ENOG4105CJ3 phosphate transporter GFC29_2208 ENOG4107GRR phosphate transport regulator GFC29_2209 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GFC29_2211 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GFC29_2212 ENOG41069ER domain protein GFC29_2216 ENOG4105CEP NADH dehydrogenase GFC29_2217 ENOG4105CAY ferredoxin--nadp reductase GFC29_2218 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GFC29_2219 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GFC29_2221 ENOG4105ZKE UPF0349 protein GFC29_2225 ENOG41083MR nifu domain-containing protein GFC29_2226 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GFC29_2227 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GFC29_2228 ENOG4105D6E homoserine dehydrogenase GFC29_2230 ENOG4105D5G Transposase GFC29_2236 ENOG4106QJ6 Integrase catalytic subunit GFC29_2243 ENOG4105D5G Transposase GFC29_2245 ENOG4105C5I Dehydrogenase GFC29_2247 ENOG4108W5N phosphatidylglycerophosphatase a GFC29_2248 ENOG4105D4U had-superfamily hydrolase, subfamily iia GFC29_225 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GFC29_2253 ENOG4105MMD transcriptional regulator GFC29_2254 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GFC29_2256 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GFC29_2257 ENOG4105FAA peptidase M23 GFC29_2258 ENOG4108YTE sporulation protein YunB GFC29_2259 ENOG4105KZD Domain of unknown function (DUF1805) GFC29_226 ENOG4105CH2 amidohydrolase GFC29_2260 ENOG4107R8B 5'-nucleotidase GFC29_2262 ENOG4105I3N Conserved Protein GFC29_2263 ENOG4105DIW FeS assembly protein SUFB GFC29_2264 ENOG4108UNV SUF system FeS assembly protein, NifU family GFC29_2266 ENOG4105JRK feS assembly protein SufD GFC29_2267 ENOG4105C3K feS assembly ATPase SufC GFC29_2269 ENOG4105D01 (LipO)protein GFC29_227 ENOG4106AUC UPF0180 protein GFC29_2270 ENOG4108UMI ABC transporter, permease GFC29_2271 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GFC29_2276 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GFC29_2277 ENOG41080E8 Transcriptional regulator, Spx MgsR family GFC29_2278 ENOG4105C1G acyl-Coa dehydrogenase GFC29_2279 ENOG4105CHU acetyl-coa acetyltransferase GFC29_228 ENOG4105D3R alkyl hydroperoxide reductase GFC29_2288 ENOG4105C4B ABC transporter, permease GFC29_229 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC29_2291 ENOG4107EF8 Glycosyl transferase (Group 1 GFC29_2293 ENOG4105K64 Glycosyl transferase, family 2 GFC29_2297 ENOG4105CHR reductase GFC29_23 ENOG4105FGM Fructosamine kinase GFC29_230 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC29_2307 ENOG4107Y03 Nitroreductase GFC29_2308 ENOG4105BZ1 (ABC) transporter GFC29_2309 ENOG4105BZ1 (ABC) transporter GFC29_231 ENOG4107ZYR domain protein GFC29_2310 ENOG4105BZU Histidine kinase GFC29_2313 ENOG4105C3M thioredoxin reductase GFC29_2319 ENOG4108RDQ ABC transporter GFC29_232 ENOG4105CN5 Metallo-Beta-Lactamase GFC29_2326 ENOG4105D5G Transposase GFC29_233 ENOG4106148 UPF0356 protein GFC29_2337 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GFC29_2338 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GFC29_234 ENOG4108X4Q Hydrolase GFC29_2340 ENOG4105XZU Preprotein translocase, subunit SecG GFC29_2342 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GFC29_2344 ENOG4105CP7 Triose-phosphate isomerase GFC29_2345 ENOG4105BZA Phosphoglycerate kinase GFC29_2349 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC29_2352 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GFC29_2353 ENOG4105KRI phosphocarrier protein (HPr GFC29_2354 ENOG4105CIE May be required for sporulation (By similarity) GFC29_2355 ENOG4105CHW UPF0052 protein GFC29_2356 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GFC29_2357 ENOG4108Z4K mutator MutT protein GFC29_2358 ENOG4105C3M thioredoxin reductase GFC29_2360 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GFC29_2361 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GFC29_2362 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GFC29_2363 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GFC29_2364 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GFC29_2365 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GFC29_2366 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GFC29_2367 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GFC29_2369 ENOG4108S4C acetyltransferase GFC29_2370 ENOG4107XGZ Hydrolase GFC29_2371 ENOG4105HKU nucleoside recognition domain-containing protein GFC29_2372 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GFC29_2373 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GFC29_2374 ENOG41086DT Membrane protein of unknown function GFC29_2376 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GFC29_2377 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GFC29_2380 ENOG41062GF Polar chromosome segregation protein GFC29_2389 ENOG4105CN1 protease GFC29_2390 ENOG4105PGM cation diffusion facilitator family transporter GFC29_2391 ENOG4105KTU Transcriptional regulator, arsr family GFC29_2394 ENOG4105C37 (CBS) domain GFC29_2397 ENOG4108JU3 Alkyl hydroperoxide reductase GFC29_2398 ENOG4105D3R alkyl hydroperoxide reductase GFC29_24 ENOG4105FBA Phospholipase Carboxylesterase GFC29_2400 ENOG4105CRP Part of the ABC transporter FtsEX involved in GFC29_2401 ENOG4105CAK Cell division ATP-binding protein ftsE GFC29_2404 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GFC29_2405 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GFC29_2411 ENOG4105MQ3 flagellar protein FliS GFC29_2412 ENOG4107RT6 flagellar hook-associated GFC29_2414 ENOG4105I03 Flagellin GFC29_2415 ENOG4105F0R Cytidylyltransferase GFC29_2418 ENOG4105D2T synthase GFC29_2419 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase GFC29_2420 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GFC29_2421 ENOG4108IAJ Nad-dependent epimerase dehydratase GFC29_2426 ENOG4105I03 Flagellin GFC29_2427 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GFC29_2428 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GFC29_2429 ENOG4105MKD GFC29_2430 ENOG4105DTJ flagellar hook-associated protein GFC29_2431 ENOG4105E1Q flagellar hook-associated protein GFC29_2435 ENOG4105XVJ Protein of unknown function (DUF327) GFC29_2438 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GFC29_2441 ENOG4105WH1 Two component transcriptional regulator luxr family GFC29_2442 ENOG4105BZU Histidine kinase GFC29_2443 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GFC29_2444 ENOG4108KGH TRANSCRIPTIONal GFC29_2445 ENOG4105ESV Glycosyl transferase, family 4 GFC29_2446 ENOG4105CJR Integral membrane protein (MviN GFC29_2449 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GFC29_245 ENOG4105CXN decarboxylase GFC29_2452 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GFC29_2454 ENOG4107BJW polysaccharide deacetylase GFC29_2456 ENOG4105RYY domain protein GFC29_246 ENOG4105EA8 2-Nitropropane dioxygenase GFC29_2463 ENOG4108JJ8 (ABC) transporter GFC29_2464 ENOG4108JJ9 ABC, transporter GFC29_2465 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GFC29_2466 ENOG4105C4M (Ubiquinol oxidase) subunit I GFC29_247 ENOG4105WBI UPF0223 protein GFC29_2471 ENOG4105DF9 Lipoate-protein, ligase GFC29_2476 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GFC29_2478 ENOG4105C19 ABC transporter GFC29_2479 ENOG4105EWM Histidine kinase GFC29_2480 ENOG4105CJZ response regulator GFC29_2484 ENOG4107V2S Transcriptional regulator GFC29_2485 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GFC29_2486 ENOG4108JUB Transcriptional regulator GFC29_2487 ENOG4105CMT Dihydroxyacetone kinase GFC29_249 ENOG4105ECY inositol monophosphatase GFC29_2490 ENOG4105KRI phosphocarrier protein (HPr GFC29_2493 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GFC29_2494 ENOG4106I4J membrane GFC29_25 ENOG4105C9Q fumarate hydratase class II GFC29_2500 ENOG4106A2Z transcriptional regulator antitoxin, MazE GFC29_2508 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC29_251 ENOG4105CI3 gtp-binding protein typa GFC29_2510 ENOG4108TDH Cell wall binding repeat 2-containing protein GFC29_2511 ENOG4105HIR S-layer domain protein GFC29_252 ENOG4105QA2 GFC29_2520 ENOG4107TT5 NLP P60 protein GFC29_2527 ENOG4105CJR Integral membrane protein (MviN GFC29_2530 ENOG4105C6Y Udp-glucose 6-dehydrogenase GFC29_2532 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GFC29_2536 ENOG4105C0D helicase GFC29_2539 ENOG4105Z8H single-stranded DNA-binding protein GFC29_2543 ENOG4105CFH Aspartokinase GFC29_2548 ENOG4105C26 Dehydrogenase GFC29_2552 ENOG4105W1N transcriptional regulator GFC29_2553 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC29_2554 ENOG41067SE Tetr family transcriptional regulator GFC29_2556 ENOG4105EVU fructokinase GFC29_2557 ENOG4105EE0 oxidoreductase GFC29_2559 ENOG4108TZY GntR Family Transcriptional Regulator GFC29_2560 ENOG4105CS2 ec 3.2.1.21 GFC29_2561 ENOG4105CK1 PTS System GFC29_2562 ENOG4105VCP PTS System GFC29_2563 ENOG4105VZJ PTS System GFC29_2564 ENOG4105DG6 mannose-6-phosphate isomerase GFC29_2566 ENOG4108M8H domain protein GFC29_2568 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GFC29_2569 ENOG4105CNN ABC, transporter GFC29_257 ENOG4108IAB Phoh family GFC29_2570 ENOG4105C2J ABC transporter GFC29_2571 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GFC29_2572 ENOG4108RVA ribokinase GFC29_2573 ENOG4105ETE Transcriptional regulator (LacI family GFC29_2574 ENOG4105DG6 mannose-6-phosphate isomerase GFC29_2577 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GFC29_2580 ENOG4105CKB glycosidase GFC29_2581 ENOG4105ETE Transcriptional regulator (LacI family GFC29_2582 ENOG410667J hydrolase GFC29_2585 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GFC29_2587 ENOG4105CGA flagellar basal-body rod protein FlgG GFC29_2589 ENOG4105DFF Rod shape-determining protein mreb GFC29_259 ENOG4105ZPI UPF0358 protein GFC29_2590 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GFC29_2592 ENOG4105FRN stage II sporulation protein GFC29_2594 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GFC29_2596 ENOG4106778 Protein of unknown function (DUF1146) GFC29_2597 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC29_2598 ENOG4105C8S subunit m GFC29_2599 ENOG4105D65 subunit l GFC29_260 ENOG4105CNI cell division protein FtsW GFC29_2600 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC29_2603 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GFC29_2604 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC29_2605 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GFC29_2606 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GFC29_2607 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GFC29_2608 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GFC29_2609 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GFC29_261 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GFC29_2610 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GFC29_2611 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GFC29_2612 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GFC29_2613 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GFC29_2614 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GFC29_2615 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GFC29_2618 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GFC29_2619 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GFC29_262 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GFC29_2620 ENOG4108UIC UPF0340 protein GFC29_2621 ENOG4108YZG isomerase GFC29_2622 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_2624 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GFC29_2625 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GFC29_2626 ENOG4108ZXQ stage ii sporulation protein r GFC29_2627 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GFC29_2628 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GFC29_263 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GFC29_2630 ENOG4105C26 Dehydrogenase GFC29_2631 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GFC29_2635 ENOG4107104 thymidine kinase GFC29_2636 ENOG41082DI 50s ribosomal protein l31 GFC29_2637 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GFC29_2638 ENOG4105CBT Fructose-1,6-bisphosphatase GFC29_2639 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GFC29_2640 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GFC29_2642 ENOG410812K response regulator receiver protein GFC29_2644 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GFC29_2646 ENOG4105D5P Methylmalonyl-coA mutase GFC29_2648 ENOG4105C1G acyl-Coa dehydrogenase GFC29_2649 ENOG4105C1G acyl-Coa dehydrogenase GFC29_2650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC29_2652 ENOG4105DF6 Fe-S oxidoreductase GFC29_2655 ENOG4105C75 arginyL-tRNA synthetase GFC29_2656 ENOG410684U Domain of unknown function (DUF1934) GFC29_2657 ENOG4105CYW agmatinase GFC29_2658 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GFC29_2659 ENOG4105BZ4 penicillin-binding protein GFC29_2660 ENOG4108XFG YwhD family GFC29_2661 ENOG4108Z4T Peptidase M50 GFC29_2662 ENOG41069HH 4-oxalocrotonate tautomerase GFC29_2663 ENOG4105C7N Xanthine uracil vitamin C permease GFC29_2666 ENOG4105DCI Phosphohydrolase GFC29_2667 ENOG4105QAT UPF0741 protein GFC29_2668 ENOG4108VCI transcription factor, rsfa family GFC29_2669 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GFC29_2670 ENOG4108IJ2 phosphate acetyltransferase GFC29_2671 ENOG4107JTW chlorite dismutase GFC29_2672 ENOG4108VKI Cell wall hydrolase GFC29_2676 ENOG4105CG3 alpha amylase, catalytic region GFC29_2677 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GFC29_2680 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GFC29_2681 ENOG4108RJ9 Glycosyl transferase, family 2 GFC29_2682 ENOG41079KZ Major Facilitator Superfamily GFC29_2684 ENOG4108K8K Transcriptional regulator GFC29_2685 ENOG4105DCF alanine dehydrogenase GFC29_2686 ENOG4105CK7 Sodium proline symporter GFC29_2687 ENOG4106PMH Extracellular solute-binding protein family 3 GFC29_2688 ENOG4105E5Q amino acid AbC transporter GFC29_2690 ENOG41060D1 Quinol oxidase GFC29_2692 ENOG4105BZ9 Cytochrome C oxidase, subunit I GFC29_2693 ENOG4105E2S oxidase) subunit II GFC29_2694 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GFC29_2695 ENOG4108IV0 ABC, transporter GFC29_2696 ENOG4105C0Z ABC transporter GFC29_2697 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GFC29_2698 ENOG4105C32 Amino acid ABC transporter (Permease) GFC29_2702 ENOG4105BZG amino acid carrier protein GFC29_2703 ENOG4105BZW Glycerate kinase GFC29_2704 ENOG4106M28 alanine racemase domain protein GFC29_2710 ENOG41067QW Transcriptional regulator GFC29_2711 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GFC29_2713 ENOG4105C0H protease GFC29_2714 ENOG4105Q2H domain protein GFC29_2717 ENOG4105BZU Histidine kinase GFC29_2718 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC29_2719 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GFC29_272 ENOG4105K4I Scp-like extracellular GFC29_2720 ENOG4105CDU Replicative dna helicase GFC29_2721 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GFC29_2722 ENOG4105BZR domain protein GFC29_2723 ENOG4108XMW Membrane GFC29_2724 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GFC29_2725 ENOG4108UUM single-stranded DNA-binding protein GFC29_2726 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GFC29_2727 ENOG4105C3G gtp-binding protein GFC29_2728 ENOG4108J2R molybdopterin oxidoreductase GFC29_2729 ENOG4105VDK protein, conserved in bacteria GFC29_273 ENOG41080XQ Signal transduction protein with cbs domains GFC29_2730 ENOG4105D8X mechanosensitive ion channel GFC29_2731 ENOG4108ZDA Sporulation protein YyaC GFC29_2733 ENOG4105FA0 parb-like partition protein GFC29_2734 ENOG4107QJE Chromosome Partitioning Protein GFC29_2735 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) GFC29_2736 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GFC29_2737 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GFC29_2738 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GFC29_274 ENOG4106UY4 Inherit from COG: Scp-like extracellular GFC29_2740 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GFC29_2741 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GFC29_2742 ENOG4105VG0 50S ribosomal protein l34 GFC29_2743 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GFC29_2744 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GFC29_2745 ENOG410848D S4 domain protein YaaA GFC29_2746 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GFC29_2747 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC29_2748 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC29_2749 ENOG4105CPI Metal Dependent Phosphohydrolase GFC29_2759 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GFC29_2761 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GFC29_2762 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GFC29_2763 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GFC29_2765 ENOG4105ZMH deoxynucleoside kinase GFC29_2767 ENOG4105VRS hydrolase family 18 GFC29_2768 ENOG4108Z6B deaminase GFC29_2769 ENOG4105C6E dna polymerase iii GFC29_2770 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GFC29_2771 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GFC29_2773 ENOG41067KS pro-sigma K processing GFC29_2780 ENOG4105DQ6 Transposase GFC29_2781 ENOG4105DQ6 Transposase GFC29_2783 ENOG4105CXN decarboxylase GFC29_2784 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GFC29_2785 ENOG4105FA2 dna polymerase iii GFC29_2786 ENOG4105MA4 psp1 domain protein GFC29_2787 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) GFC29_2788 ENOG41060K3 Methyltransferase GFC29_2789 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GFC29_279 ENOG4105WUC UPF0298 protein GFC29_2790 ENOG4105KRN Transcriptional regulator, abrb family GFC29_2792 ENOG4105F8V Hydrolase, tatD family GFC29_2793 ENOG41069ER domain protein GFC29_2794 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GFC29_2795 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GFC29_2796 ENOG4105XFA sporulation peptidase YabG GFC29_2797 ENOG4105W42 Veg protein GFC29_2799 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GFC29_2800 ENOG4105DFT pur operon repressor GFC29_2801 ENOG4105KME endoribonuclease L-psp GFC29_2802 ENOG4105K4W Could be involved in septation (By similarity) GFC29_2803 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GFC29_2805 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GFC29_2806 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GFC29_2808 ENOG4108JA2 transcriptioN-repair coupling factor GFC29_2809 ENOG4108M14 stage v sporulation protein t GFC29_2811 ENOG4108IY2 MazG family GFC29_2812 ENOG41082I2 s4 domain protein GFC29_2813 ENOG4105VYY sporulation protein yabp GFC29_2816 ENOG41060GV RNA binding s1 domain protein GFC29_282 ENOG4106H78 methyltransferase GFC29_2822 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GFC29_2823 ENOG4108UGV hypoxanthine phosphoribosyltransferase GFC29_2824 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GFC29_2825 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GFC29_2826 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GFC29_2827 ENOG4105C6T cysteine synthase GFC29_2828 ENOG4105CRQ synthase (Component I) GFC29_2829 ENOG4105DDQ anthranilate synthase GFC29_283 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GFC29_2830 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GFC29_2831 ENOG4105EEI dihydropteroate synthase GFC29_2832 ENOG4105KRF dihydroneopterin aldolase GFC29_2833 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GFC29_2835 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GFC29_284 ENOG4105D78 K07001 NTE family protein GFC29_285 ENOG4105CDE UPF0348 protein GFC29_2858 ENOG4108Z0C Uvrb UvrC protein GFC29_2859 ENOG41066A3 ATP guanido phosphotransferase GFC29_286 ENOG41063PX domain protein GFC29_2861 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GFC29_2862 ENOG4105CTP PilT protein domain protein GFC29_2863 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GFC29_2864 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GFC29_2865 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GFC29_2866 ENOG4105D7W serine acetyltransferase GFC29_2867 ENOG4105C8N cysteinyl-tRNA synthetase GFC29_2869 ENOG4105C2N RNA methyltransferase TrmH family group 3 GFC29_287 ENOG4105KNH Nucleic acid-binding protein GFC29_2870 ENOG4105M0M Tetracycline resistance protein GFC29_2871 ENOG4105QIV RNA polymerase GFC29_2872 ENOG410683Z Preprotein translocase SecE subunit GFC29_2873 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GFC29_2874 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GFC29_2875 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GFC29_2877 ENOG4108VZM 50s ribosomal protein L10 GFC29_2878 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GFC29_2879 ENOG4107Y49 methyltransferase GFC29_288 ENOG41067VY 50S ribosomal protein L32 GFC29_2880 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC29_2881 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC29_2882 ENOG4105XPM ribosomal protein GFC29_2883 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GFC29_2884 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GFC29_2885 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GFC29_2886 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GFC29_2887 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GFC29_2888 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GFC29_2889 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GFC29_289 ENOG4105E39 Enoyl-CoA hydratase GFC29_2890 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GFC29_2891 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GFC29_2892 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GFC29_2893 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GFC29_2894 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GFC29_2895 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GFC29_2896 ENOG41082SA 50s ribosomal protein l29 GFC29_2897 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GFC29_2898 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GFC29_2899 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GFC29_2900 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GFC29_2901 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GFC29_2902 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GFC29_2903 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GFC29_2904 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GFC29_2905 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GFC29_2906 ENOG4105VPB 50S ribosomal protein L30 GFC29_2907 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GFC29_2908 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GFC29_2909 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GFC29_2910 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GFC29_2912 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GFC29_2913 ENOG41067V7 50S ribosomal protein L36 GFC29_2914 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GFC29_2915 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GFC29_2916 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GFC29_2917 ENOG4108ZT0 50S ribosomal protein l17 GFC29_2918 ENOG4108JJB ABC transporter GFC29_2919 ENOG4108JJB ABC transporter GFC29_2920 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GFC29_2921 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GFC29_2922 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GFC29_2923 ENOG4108UJD 30S ribosomal protein S9 GFC29_2927 ENOG4107TVC Glycosyl transferase, family 2 GFC29_2929 ENOG4107TVC Glycosyl transferase, family 2 GFC29_293 ENOG41074B2 UPF0747 protein GFC29_2932 ENOG4105D1F ATP-binding protein GFC29_2935 ENOG4108NMV polysaccharide deacetylase GFC29_294 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GFC29_295 ENOG41068DC Essential cell division protein (By similarity) GFC29_2954 ENOG4105EMN RNA polymerase sigma factor GFC29_2955 ENOG4105KXB anti-sigma factor GFC29_2956 ENOG4105C8B TIGR00159 family GFC29_2957 ENOG4107U5W ybbr family GFC29_2958 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GFC29_296 ENOG4105CJN penicillin-binding protein GFC29_2961 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GFC29_2964 ENOG4105E6M Sulphatase-modifying factor protein GFC29_2968 ENOG4107YBY Hydrolase GFC29_297 ENOG4105CJN penicillin-binding protein GFC29_2972 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GFC29_2973 ENOG4105KVH Transcriptional regulator GFC29_2975 ENOG4108ZJ4 polysaccharide deacetylase GFC29_2978 ENOG4108DBC nitroreductase GFC29_2979 ENOG410874W AraC family transcriptional regulator GFC29_298 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GFC29_2980 ENOG4105C6X Major Facilitator GFC29_2985 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GFC29_2987 ENOG4105DWF phosphomethylpyrimidine kinase GFC29_2988 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GFC29_2989 ENOG4105E4F Isochorismate synthase GFC29_2990 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GFC29_2991 ENOG4105WQI isochorismatase GFC29_2992 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_2993 ENOG4105WQT MbtH domain protein GFC29_2995 ENOG410874W AraC family transcriptional regulator GFC29_2999 ENOG4107Y03 Nitroreductase GFC29_3 ENOG4108SU4 UPF0309 protein GFC29_300 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GFC29_3000 ENOG4108SA1 esterase GFC29_3001 ENOG4105NIV Esterase GFC29_3002 ENOG4105EHG Permease protein GFC29_3003 ENOG4105DQ5 transport system permease protein GFC29_3005 ENOG4105E0A ABC, transporter GFC29_301 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GFC29_3010 ENOG4107ZXU DSBA oxidoreductase GFC29_3011 ENOG4105E0M Sulfatase GFC29_3014 ENOG4105CZN Potassium uptake protein GFC29_3015 ENOG4105C0X amino acid GFC29_302 ENOG4105CNI cell division protein FtsW GFC29_3020 ENOG4108TGC Acyltransferase GFC29_3028 ENOG4105WH1 Two component transcriptional regulator luxr family GFC29_303 ENOG4105D4A Cell wall formation (By similarity) GFC29_3030 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GFC29_3031 ENOG4108ZJ4 polysaccharide deacetylase GFC29_3032 ENOG4107ZTW SNARE associated Golgi GFC29_3034 ENOG4105CPF Cell wall formation (By similarity) GFC29_3035 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GFC29_3037 ENOG4105C1J atp-dependent rna helicase GFC29_3039 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GFC29_304 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GFC29_3040 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GFC29_3041 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GFC29_3043 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GFC29_3046 ENOG410906U SprT-like GFC29_305 ENOG4108R2U division initiation protein GFC29_3065 ENOG4105K8N protein family UPF0079, ATPase GFC29_3066 ENOG41072GX Peptidase M22 Glycoprotease GFC29_3067 ENOG410801F ribosomal-protein-alanine acetyltransferase GFC29_3068 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GFC29_3069 ENOG4105C5H ABC transporter GFC29_307 ENOG4105K67 small basic protein GFC29_3070 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GFC29_3071 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GFC29_3072 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GFC29_3073 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GFC29_3075 ENOG4108TYN CAAX amino terminal protease family protein GFC29_3077 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GFC29_3078 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GFC29_3079 ENOG4105VTR Integrase GFC29_308 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GFC29_309 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GFC29_3099 ENOG4108NF7 phage-type endonuclease GFC29_310 ENOG4108AWX Sporulation factor SpoIIGA GFC29_3100 ENOG4108PNI recT protein GFC29_311 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC29_3116 ENOG4105IG6 Phage terminase, large subunit GFC29_3117 ENOG4108MDF Phage Portal Protein GFC29_3118 ENOG4106CGH Phage Mu protein F like protein GFC29_3125 ENOG41060SN GFC29_3127 ENOG4105PQS phage protein GFC29_3128 ENOG4105FR7 XkdM protein, phage-like element PBSX GFC29_3129 ENOG4105MTC XkdN-like protein GFC29_313 ENOG4105WR5 sporulation protein, YlmC YmxH family GFC29_3130 ENOG4108FKH Transglycosylase SLT domain GFC29_3131 ENOG4108WZM domain protein GFC29_3132 ENOG4105X7F GFC29_3134 ENOG4105MFU Protein of unknown function (DUF2634) GFC29_3135 ENOG41066EA baseplate J family protein GFC29_314 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GFC29_3143 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC29_3146 ENOG4105DQ6 Transposase GFC29_315 ENOG4105DFA alanine racemase domain protein GFC29_3153 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GFC29_3156 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GFC29_3157 ENOG4105C7N Xanthine uracil vitamin C permease GFC29_316 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GFC29_3166 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GFC29_3167 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GFC29_3168 ENOG4105C83 adenylosuccinate lyase GFC29_3169 ENOG4105C8V SAICAR synthetase GFC29_317 ENOG41067XK integral membrane protein GFC29_3170 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GFC29_3171 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GFC29_3172 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GFC29_3174 ENOG4105CXB phosphoribosylaminoimidazole synthetase GFC29_3175 ENOG4108V3E phosphoribosylglycinamide formyltransferase GFC29_3176 ENOG4105DC1 bifunctional purine biosynthesis protein purh GFC29_3178 ENOG4105C12 Phosphoribosylglycinamide synthetase GFC29_318 ENOG4105DBK s4 domain protein GFC29_3180 ENOG4108R5T secreted protein GFC29_3181 ENOG4105KGF protein, YerC YecD GFC29_3182 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) GFC29_3184 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GFC29_3186 ENOG4105C26 Dehydrogenase GFC29_3188 ENOG4105WH1 Two component transcriptional regulator luxr family GFC29_3191 ENOG4105C19 ABC transporter GFC29_3194 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GFC29_3195 ENOG4107RUY (E1 component), alpha subunit GFC29_3197 ENOG4107QKR Dehydrogenase GFC29_3198 ENOG4107BJW polysaccharide deacetylase GFC29_3199 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GFC29_320 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GFC29_3204 ENOG410838F Glycosyl transferase family 2 GFC29_3205 ENOG4105CPN adenine deaminase GFC29_3206 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GFC29_3207 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GFC29_3208 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GFC29_3209 ENOG4108HQR Glycine betaine GFC29_321 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GFC29_3210 ENOG4108IJ8 ABC transporter GFC29_3211 ENOG4105E90 ABC transporter GFC29_3218 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GFC29_3219 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) GFC29_322 ENOG4105C34 Pseudouridine synthase GFC29_3226 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GFC29_3227 ENOG4105F38 ABC transporter, permease GFC29_3228 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component GFC29_3229 ENOG4107RUE extracellular solute-binding protein family 1 GFC29_323 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GFC29_3233 ENOG4105BZU Histidine kinase GFC29_3236 ENOG4105DZ6 Band 7 protein GFC29_3241 ENOG4105CBD Diacylglycerol kinase GFC29_3245 ENOG4108NEV two component transcriptional regulator, LytTR family GFC29_3248 ENOG4105NAE bifunctional deaminase-reductase domain protein GFC29_325 ENOG4105CXT aspartate transcarbamylase GFC29_3254 ENOG4108RDQ ABC transporter GFC29_3257 ENOG4105YA8 Transcriptional regulator GFC29_326 ENOG4105CD3 dihydroorotase GFC29_3261 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GFC29_3263 ENOG4105CYC Transferase GFC29_3267 ENOG4105C0H protease GFC29_3270 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GFC29_3271 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_3272 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GFC29_3275 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GFC29_3277 ENOG4105XRQ Xanthine dehydrogenase accessory factor GFC29_3281 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) GFC29_3282 ENOG4105C84 Histidine ammonia-lyase GFC29_3283 ENOG4105CGP Urocanate hydratase GFC29_3284 ENOG4105CI2 imidazolone-5-propionate hydrolase GFC29_3285 ENOG4108ZCF integral membrane protein GFC29_3286 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) GFC29_3287 ENOG4107QR9 Iron-sulfur cluster binding protein GFC29_3288 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC29_3289 ENOG4105JXH GntR family transcriptional regulator GFC29_329 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GFC29_3290 ENOG4105DAA L-lactate GFC29_3291 ENOG4105CQB FAD linked oxidase domain protein GFC29_3292 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GFC29_3297 ENOG4108Z73 Siroheme synthase GFC29_3298 ENOG4108TN2 lmbE family GFC29_33 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase GFC29_330 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GFC29_3301 ENOG410855V Acylphosphatase GFC29_3302 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GFC29_3303 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GFC29_3305 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GFC29_3306 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GFC29_3307 ENOG4107RIQ Sulfate adenylate transferase GFC29_3309 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GFC29_331 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GFC29_3311 ENOG41068PA UPF0435 protein GFC29_3312 ENOG4105KJF protein tyrosine phosphatase GFC29_3314 ENOG4107U9T Pfam:Ribonuclease_BN GFC29_3316 ENOG4108ISG Major Facilitator GFC29_3318 ENOG4105UPD Calcium Proton GFC29_3326 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GFC29_3339 ENOG4105D7V transposase GFC29_334 ENOG4105F23 Fibronectin-binding protein GFC29_3340 ENOG4105CNG UPF0061 protein GFC29_3349 ENOG4105C8J )-transporter GFC29_3352 ENOG4105CR4 methylisocitrate lyase GFC29_3353 ENOG4105DXD 2-methylcitrate dehydratase GFC29_3356 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GFC29_3357 ENOG4108S4H thioesterase Superfamily protein GFC29_3359 ENOG4105WH1 Two component transcriptional regulator luxr family GFC29_336 ENOG4105DSJ YicC domain protein GFC29_3365 ENOG4105ECP epimerase GFC29_3366 ENOG410902V Modulates RecA activity (By similarity) GFC29_3367 ENOG4105CHR reductase GFC29_337 ENOG4105KC4 UPF0296 protein GFC29_3370 ENOG4105XHU Acid-soluble spore protein K GFC29_3373 ENOG41067AE Membrane-bound metal-dependent hydrolase GFC29_3375 ENOG4106BXE GFC29_3376 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GFC29_3379 ENOG4105EVI UPF0374 protein GFC29_338 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GFC29_3380 ENOG4105C3U ABC transporter GFC29_3381 ENOG4108JQ7 (ABC) transporter GFC29_3382 ENOG4105DEF Extracellular solute-binding protein, family 5 GFC29_3383 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC29_3384 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GFC29_3386 ENOG4107NBY Membrane GFC29_339 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GFC29_3390 ENOG4105CBC glutamate synthase GFC29_3391 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GFC29_3392 ENOG4108IUW ABC transporter GFC29_3396 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC29_3397 ENOG4105G5W regulator Fur family GFC29_3398 ENOG4105TUA UPF0295 protein GFC29_340 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GFC29_341 ENOG4105C25 Primosomal protein n' GFC29_342 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GFC29_343 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GFC29_3430 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GFC29_3432 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GFC29_3434 ENOG4105CYN Serine protein kinase GFC29_3436 ENOG4105C3F Signal peptidase i GFC29_3438 ENOG4105C19 ABC transporter GFC29_3439 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GFC29_344 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GFC29_3440 ENOG41062D9 Histidine kinase GFC29_3442 ENOG4108MRH transcriptional regulatory protein GFC29_3443 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GFC29_3444 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GFC29_3445 ENOG4107QJT sodium dicarboxylate symporter GFC29_3446 ENOG4105C2I pirin domain protein GFC29_3447 ENOG4105CS1 NAD(P)H quinone oxidoreductase GFC29_345 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GFC29_3450 ENOG4105D7V transposase GFC29_3452 ENOG4105C37 (CBS) domain GFC29_3453 ENOG4108YBP pseudouridine synthase GFC29_3457 ENOG4105CG3 alpha amylase, catalytic region GFC29_3458 ENOG41080XP Cbs domain GFC29_346 ENOG4108ZF3 Phosphatase GFC29_3460 ENOG4105EMU Dehydrogenase GFC29_3461 ENOG4105BZU Histidine kinase GFC29_3462 ENOG4105WH1 Two component transcriptional regulator luxr family GFC29_3467 ENOG4107ZTW SNARE associated Golgi GFC29_3469 ENOG41069DP small acid-soluble spore protein GFC29_347 ENOG4105D9P serine threonine protein kinase GFC29_3471 ENOG4105ED1 spovr family GFC29_3474 ENOG4105XTG Pfam:DUF156 GFC29_3475 ENOG4105VFE sira family GFC29_3476 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GFC29_3477 ENOG4105C72 UPF0176 protein GFC29_3479 ENOG4105VFE sira family GFC29_348 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GFC29_3480 ENOG4107TPS domain protein GFC29_3481 ENOG41087NI Sulfite exporter TauE/SafE GFC29_3482 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GFC29_3483 ENOG4105NQC Flavodoxin GFC29_3485 ENOG4108ZCF integral membrane protein GFC29_3486 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GFC29_3487 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GFC29_3489 ENOG4105D22 carbon starvation protein GFC29_349 ENOG4105DJV ribulose-phosphate 3-epimerase GFC29_3490 ENOG4105VCD cytoplasmic protein GFC29_3491 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GFC29_3493 ENOG4108YYS metal-dependent hydrolase (By similarity) GFC29_3494 ENOG4105DR4 Methyltransferase GFC29_3495 ENOG4105ETU transcriptional activator (TenA GFC29_3497 ENOG4108JJB ABC transporter GFC29_3498 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GFC29_3499 ENOG4108VEU Thiamine monophosphate synthase GFC29_350 ENOG4105FJ0 thiamine GFC29_3500 ENOG41080HI glycine oxidase GFC29_3502 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GFC29_3503 ENOG4105D06 uba thif-type nad fad binding protein GFC29_3505 ENOG4105C37 (CBS) domain GFC29_3507 ENOG4105DRP amino acid AbC transporter GFC29_3508 ENOG4105CDA abc transporter atp-binding protein GFC29_351 ENOG4105VB9 50S ribosomal protein l28 GFC29_3515 ENOG4108UH6 UPF0754 membrane protein GFC29_3516 ENOG4105WZB UPF0342 protein GFC29_3518 ENOG4105D4P Coproporphyrinogen iii oxidase GFC29_352 ENOG4108ZAA Alkaline-shock protein GFC29_3520 ENOG4108IUX (ABC) transporter GFC29_3521 ENOG4105RHA ABC transporter, permease GFC29_3522 ENOG4105EQI Metal Dependent Phosphohydrolase GFC29_3524 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GFC29_3525 ENOG4105NBU tryptophan transport protein GFC29_3528 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) GFC29_353 ENOG4105DP4 dak2 domain fusion protein ylov GFC29_3530 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GFC29_3531 ENOG4105K59 histidine triad (HIT) protein GFC29_3534 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GFC29_3537 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GFC29_3538 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GFC29_3539 ENOG4105C1Q protoporphyrinogen oxidase GFC29_3541 ENOG4105ECB domain protein GFC29_3543 ENOG4107T3P ABC, transporter GFC29_3546 ENOG4106AXD GFC29_3547 ENOG4108RQ5 Beta-lactamase domain-containing protein GFC29_3548 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_3549 ENOG4108UMN azlc family GFC29_355 ENOG4105EJQ L-serine dehydratase GFC29_3552 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GFC29_3556 ENOG4105XVF Competence transcription factor GFC29_3559 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination GFC29_356 ENOG4105CB5 ATP-dependent DNA helicase recG GFC29_3560 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GFC29_3562 ENOG4105EYH Exonuclease GFC29_357 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GFC29_3571 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_3573 ENOG4105ERH Fumarylacetoacetate hydrolase GFC29_3574 ENOG4105C8Y Acetylornithine aminotransferase GFC29_3575 ENOG4105YHS UPF0344 protein GFC29_3577 ENOG4105CAQ asparagine synthetase GFC29_3578 ENOG4105UQX Mate efflux family protein GFC29_3579 ENOG4106HBX Transcriptional Regulator AraC Family GFC29_358 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GFC29_3581 ENOG4107FKK extracellular solute-binding protein family 1 GFC29_3583 ENOG4105EG2 ABC transporter, permease GFC29_3584 ENOG4108IUK alpha amylase, catalytic GFC29_3586 ENOG4105ETE Transcriptional regulator (LacI family GFC29_359 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GFC29_3590 ENOG4108VPT UPF0234 protein GFC29_3591 ENOG4105QNR S1 RNA binding domain protein GFC29_3592 ENOG4105DIH basic membrane GFC29_3593 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_3594 ENOG4108KYE ABC-2 type transporter GFC29_3596 ENOG4105CJ1 ABC, transporter GFC29_3597 ENOG4105BZU Histidine kinase GFC29_3598 ENOG4105WH1 Two component transcriptional regulator luxr family GFC29_36 ENOG4105VMP Transcriptional regulator GFC29_360 ENOG4105CHR reductase GFC29_3600 ENOG4105EPR degv family GFC29_3601 ENOG4107AYK membrAne GFC29_3603 ENOG4108KP7 hydrolase GFC29_3604 ENOG4108MXZ Esterase GFC29_3605 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GFC29_3606 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GFC29_3607 ENOG4105CVM Molybdenum cofactor synthesis domain protein GFC29_3608 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GFC29_3609 ENOG4108ZAF Molybdopterin GFC29_361 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GFC29_3611 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GFC29_3612 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GFC29_3613 ENOG4105CAS nag kinase GFC29_3617 ENOG4105DBV ornithine carbamoyltransferase GFC29_3619 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GFC29_362 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GFC29_3624 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GFC29_3625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GFC29_3628 ENOG4108KU1 UPF0736 protein GFC29_363 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GFC29_3630 ENOG4108J59 Extracellular solute-binding protein, family 5 GFC29_3631 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC29_3632 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GFC29_3634 ENOG4108JQ7 (ABC) transporter GFC29_3636 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GFC29_3637 ENOG4108ZCF integral membrane protein GFC29_3638 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis GFC29_3639 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GFC29_364 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GFC29_3641 ENOG4105DPN Oligoendopeptidase f GFC29_3643 ENOG4105T58 Dithiol-disulfide isomerase GFC29_3644 ENOG4108Z18 K06886 hemoglobin GFC29_3645 ENOG4105E4C Lytic transglycosylase catalytic GFC29_3646 ENOG4105MIX Adenylate cyclase GFC29_3647 ENOG4106EFP UPF0738 protein GFC29_3649 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GFC29_365 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GFC29_3650 ENOG4105EMS pseudouridine synthase GFC29_3651 ENOG4107S1Q Phosphatase GFC29_3652 ENOG4105CNI cell division protein FtsW GFC29_3655 ENOG4108KS4 Spore coat protein GFC29_3656 ENOG4107SBE Glycosyl transferase (Group 1 GFC29_3657 ENOG4107SBE Glycosyl transferase (Group 1 GFC29_3658 ENOG4108IAJ Nad-dependent epimerase dehydratase GFC29_3668 ENOG41090VF Stage v sporulation protein ac GFC29_3669 ENOG4105CZ3 stage V sporulation protein ad GFC29_367 ENOG4105K5M 30s ribosomal protein S16 GFC29_3672 ENOG4108QY0 Membrane GFC29_3674 ENOG4105SZ6 Thioredoxin GFC29_3678 ENOG4105ENA helicase GFC29_368 ENOG4105VB6 UPF0109 protein GFC29_3681 ENOG41082BV acetyltransferase GFC29_3682 ENOG4108ZMI UPF0477 protein GFC29_3686 ENOG4105CY2 Citrate transporter GFC29_3687 ENOG4105DTD Dehydrogenase GFC29_3688 ENOG4105C28 cystathionine GFC29_3689 ENOG4105C28 cystathionine GFC29_3692 ENOG4105DUM transcriptional regulator, lysR family GFC29_3696 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) GFC29_37 ENOG4105NX3 Membrane GFC29_370 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GFC29_3701 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC29_371 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GFC29_3718 ENOG4105EAB amino acid AbC transporter GFC29_3719 ENOG4105E5Q amino acid AbC transporter GFC29_372 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GFC29_3720 ENOG4105CDA abc transporter atp-binding protein GFC29_3729 ENOG4105CUB amino acid GFC29_3730 ENOG4105BZU Histidine kinase GFC29_3731 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC29_3733 ENOG4105K4H Nlp p60 protein GFC29_3739 ENOG4108ZRV stage ii sporulation protein p GFC29_374 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GFC29_3742 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC29_3746 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GFC29_375 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GFC29_3751 ENOG4105PGM cation diffusion facilitator family transporter GFC29_3761 ENOG4105VPX protein, conserved in bacteria GFC29_3762 ENOG4105C59 p-type ATPase GFC29_3766 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GFC29_3767 ENOG4105BZU Histidine kinase GFC29_377 ENOG4105D00 flagellar biosynthetic protein flhB GFC29_3773 ENOG4107TWT Cytochrome c biogenesis protein GFC29_3774 ENOG4105CRE cytochrome C GFC29_3775 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GFC29_3776 ENOG4107QIV Cytochrome c biogenesis protein GFC29_378 ENOG4105CMV Succinyl-CoA synthetase subunit beta GFC29_3780 ENOG4107R16 Multicopper oxidase GFC29_3782 ENOG4105CAQ asparagine synthetase GFC29_379 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GFC29_3793 ENOG4105M6F mutator MutT protein GFC29_3794 ENOG4108F3G Type I restriction-modification system, R subunit GFC29_3795 ENOG4107QM2 Aldo Keto reductase GFC29_38 ENOG4105E0A ABC, transporter GFC29_380 ENOG4105C79 DNA protecting protein DprA GFC29_3800 ENOG4106ETB IIa component GFC29_3801 ENOG4106ETB IIa component GFC29_381 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GFC29_382 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GFC29_383 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC29_3838 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC29_384 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GFC29_3844 ENOG4108IMY Transcriptional regulator GFC29_385 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GFC29_3853 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GFC29_386 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) GFC29_3869 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GFC29_387 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GFC29_3871 ENOG4108N0N Phage Terminase Large Subunit GFC29_388 ENOG4108ZC9 flagellar basal-body rod protein flgc GFC29_389 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GFC29_39 ENOG4105TVJ transport system, permease GFC29_390 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GFC29_391 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GFC29_394 ENOG4106YF4 Flagellar biosynthesis chaperone GFC29_396 ENOG410696Y Flagellar hook-length control protein GFC29_397 ENOG410822I Flagellar hook capping protein GFC29_398 ENOG4108JQA flagellar GFC29_399 ENOG41068WV flagellar FlbD family protein GFC29_40 ENOG4105DQ5 transport system permease protein GFC29_401 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GFC29_402 ENOG4105DD5 Flagellar motor switch protein GFC29_403 ENOG4107YTP response regulator receiver protein GFC29_405 ENOG4105CN7 Flagellar biosynthetic protein FliP GFC29_406 ENOG4105VS8 Flagellar biosynthetic protein fliq GFC29_407 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GFC29_408 ENOG4105D00 flagellar biosynthetic protein flhB GFC29_409 ENOG4105D7B Flagellar biosynthesis protein flha GFC29_410 ENOG4105FZW flagellar biosynthesis regulator FlhF GFC29_412 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GFC29_413 ENOG4105CBS Chea signal transduction histidine kinase GFC29_414 ENOG4108V3W Chemotaxis protein, CheW GFC29_416 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GFC29_418 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GFC29_421 ENOG4105CE9 30S ribosomal protein S2 GFC29_422 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GFC29_423 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GFC29_424 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GFC29_425 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GFC29_426 ENOG4105KNE Phosphatidate cytidylyltransferase GFC29_427 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GFC29_428 ENOG4105DZP Membrane-associated zinc metalloprotease GFC29_429 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GFC29_430 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GFC29_431 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GFC29_432 ENOG4105CHV Transcription elongation factor NusA GFC29_433 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GFC29_434 ENOG4105VHM ribosomal protein GFC29_435 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GFC29_436 ENOG4105W7A Protein of unknown function (DUF503) GFC29_437 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GFC29_438 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GFC29_439 ENOG4105DTN riboflavin biosynthesis protein ribF GFC29_440 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GFC29_441 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GFC29_443 ENOG4105C1V Peptidase, M16 GFC29_445 ENOG4105E35 Dipicolinate synthase subunit A GFC29_446 ENOG4108S0H Dipicolinic acid synthetase, b subunit GFC29_447 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GFC29_449 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GFC29_451 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GFC29_453 ENOG4105CNU cell division protein FtsK GFC29_454 ENOG4105FDP GntR family transcriptional regulator GFC29_455 ENOG4105DIH basic membrane GFC29_456 ENOG4108JQ9 ABC transporter GFC29_457 ENOG4105UIB (ABC) transporter GFC29_461 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GFC29_462 ENOG4105XZV Protein of unknown function (DUF3243) GFC29_465 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GFC29_466 ENOG4105CEV competence damage-inducible protein GFC29_467 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GFC29_469 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GFC29_47 ENOG4105CSV Glutaminase GFC29_470 ENOG4105D48 metallophosphoesterase GFC29_471 ENOG4105MCT stage V sporulation protein S GFC29_473 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GFC29_474 ENOG4105DQU oxidoreductase, subunit beta GFC29_475 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GFC29_479 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GFC29_480 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GFC29_481 ENOG4106KNT transcriptional regulator GFC29_484 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GFC29_487 ENOG4105K4I Scp-like extracellular GFC29_488 ENOG4105CIG ABC transporter GFC29_49 ENOG4105M6F mutator MutT protein GFC29_493 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GFC29_495 ENOG4108JYZ YitT family GFC29_496 ENOG4108T5E Copper resistance protein GFC29_497 ENOG4105KTB nuclear export factor GLE1 GFC29_498 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GFC29_504 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC29_505 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_506 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GFC29_507 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GFC29_508 ENOG4106F1P AAA ATPase, central domain protein GFC29_51 ENOG4106P55 Transcriptional regulator GFC29_512 ENOG4105CEY Amp-dependent synthetase and ligase GFC29_513 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GFC29_514 ENOG4105CHU acetyl-coa acetyltransferase GFC29_515 ENOG4105EN6 Membrane GFC29_516 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GFC29_517 ENOG4105CXI aluminum resistance protein GFC29_518 ENOG4105KV4 Transcriptional regulator GFC29_519 ENOG4105C5F glutamine synthetase GFC29_52 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GFC29_520 ENOG4105K59 histidine triad (HIT) protein GFC29_521 ENOG4105D5G Transposase GFC29_522 ENOG41063SB peptidase GFC29_526 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GFC29_527 ENOG41068KG domain protein GFC29_536 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GFC29_537 ENOG41067Z0 domain protein GFC29_538 ENOG4108SVB resolvase GFC29_539 ENOG4105VPS UPF0291 protein GFC29_542 ENOG4105VXM UPF0154 protein GFC29_544 ENOG4107QIV Cytochrome c biogenesis protein GFC29_545 ENOG4107YTP response regulator receiver protein GFC29_548 ENOG4105F0V Cell wall hydrolase GFC29_549 ENOG41076DU acid-soluble spore protein P GFC29_551 ENOG410746C Acid-soluble spore protein O GFC29_552 ENOG4108I0Z Aconitate hydratase GFC29_557 ENOG41081VK Ribonuclease GFC29_564 ENOG4105BZU Histidine kinase GFC29_565 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator GFC29_566 ENOG4105C2F Histidine kinase GFC29_567 ENOG4108VAC response regulator GFC29_568 ENOG4105DFW ABC transporter GFC29_569 ENOG4105C2J ABC transporter GFC29_57 ENOG4105DTN riboflavin biosynthesis protein ribF GFC29_570 ENOG4108HWW ABC transporter GFC29_572 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_574 ENOG4108JQ7 (ABC) transporter GFC29_575 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GFC29_577 ENOG4105DEF Extracellular solute-binding protein, family 5 GFC29_579 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GFC29_582 ENOG4107YHD transcriptional regulator GFC29_583 ENOG4105C26 Dehydrogenase GFC29_585 ENOG4105EU0 Major facilitator Superfamily GFC29_590 ENOG4108JPW Aminotransferase GFC29_591 ENOG4105CK7 Sodium proline symporter GFC29_592 ENOG4105KK4 UPF0060 membrane protein GFC29_595 ENOG4105CK5 oxidoreductase GFC29_596 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GFC29_597 ENOG4108UHU Aldolase GFC29_598 ENOG4105D7K pfkb domain protein GFC29_599 ENOG4108Z5V transcriptional regulator, merr family GFC29_601 ENOG4107VFR oxidoreductase GFC29_605 ENOG4108MJI response regulator GFC29_609 ENOG4106YBV Methyl-accepting chemotaxis GFC29_61 ENOG4105ERH Fumarylacetoacetate hydrolase GFC29_618 ENOG4105CZ9 Domain of unknown function (DU1801) GFC29_619 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GFC29_622 ENOG410645S MarR family Transcriptional regulator GFC29_624 ENOG4105CMG Carbohydrate kinase GFC29_625 ENOG4105C6Z Gluconate GFC29_628 ENOG4105C5Q Transcriptional regulator GFC29_629 ENOG4105CBC glutamate synthase GFC29_630 ENOG4105BZ8 glutamate synthase GFC29_636 ENOG4107SJI Dehydrogenase GFC29_639 ENOG4105G9B Transcriptional regulator GFC29_64 ENOG4105DWT malate dehydrogenase (quinone) GFC29_640 ENOG4105C26 Dehydrogenase GFC29_641 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GFC29_643 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GFC29_645 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GFC29_646 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GFC29_648 ENOG410829K Lysine exporter protein (Lyse ygga) GFC29_651 ENOG4105DRP amino acid AbC transporter GFC29_652 ENOG4105EAD ABC transporter GFC29_655 ENOG4105ZKE UPF0349 protein GFC29_657 ENOG4105EC8 Methyl-accepting chemotaxis GFC29_658 ENOG4106YBV Methyl-accepting chemotaxis GFC29_661 ENOG41086D8 Transcriptional regulator GFC29_663 ENOG4105C2F Histidine kinase GFC29_664 ENOG4105EQD regulatoR GFC29_665 ENOG4105DFW ABC transporter GFC29_667 ENOG4108HWW ABC transporter GFC29_67 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GFC29_670 ENOG4105EF1 ribulokinase GFC29_673 ENOG4105DFW ABC transporter GFC29_674 ENOG4105C2J ABC transporter GFC29_675 ENOG4105CNN ABC, transporter GFC29_677 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GFC29_678 ENOG4107SET aldo keto reductase GFC29_68 ENOG4105ES4 Nitrilase GFC29_680 ENOG4105C2F Histidine kinase GFC29_681 ENOG4105EQD regulatoR GFC29_682 ENOG4105XN3 extracellular solute-binding protein family 1 GFC29_683 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GFC29_69 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GFC29_690 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GFC29_694 ENOG4107XBN GntR Family Transcriptional Regulator GFC29_695 ENOG4105D2H Uronic isomerase GFC29_697 ENOG4105DMW Dehydrogenase reductase GFC29_701 ENOG4105CTM Glycoside hydrolase family 5 GFC29_702 ENOG4105C93 Xylose Isomerase GFC29_703 ENOG4105CMG Carbohydrate kinase GFC29_704 ENOG4105MKU Transcriptional regulator GFC29_708 ENOG4105CGU Enoyl-CoA hydratase GFC29_71 ENOG4108RCF TRANSCRIPTIONal GFC29_710 ENOG4108HRK Histidine kinase GFC29_711 ENOG4105DY9 regulatoR GFC29_714 ENOG4105V75 Transcriptional regulator GFC29_715 ENOG4107S6Z Na H antiporter GFC29_716 ENOG4105RWS endonuclease I GFC29_718 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GFC29_719 ENOG4105E98 transcriptional regulator DeoR family GFC29_72 ENOG4108IMY Transcriptional regulator GFC29_720 ENOG4105DE4 1-phosphofructokinase GFC29_721 ENOG4105DM4 PTS System GFC29_722 ENOG4108PJD permease GFC29_725 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GFC29_726 ENOG4105BZU Histidine kinase GFC29_728 ENOG4105EXQ uroporphyrinogen iii synthase hem4 GFC29_73 ENOG4105HDK L-asparaginase GFC29_732 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GFC29_733 ENOG4105DPN Oligoendopeptidase f GFC29_74 ENOG4108IJ0 Aspartate ammonia-lyase GFC29_740 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GFC29_741 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GFC29_743 ENOG4108JJB ABC transporter GFC29_744 ENOG4105E4R Precorrin-3B C17-methyltransferase GFC29_745 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GFC29_746 ENOG4108JTQ reductase GFC29_747 ENOG41081F0 Precorrin-8x methylmutase GFC29_748 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GFC29_749 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase GFC29_751 ENOG4105CIA precorrin-4 C(11)-methyltransferase GFC29_752 ENOG4108P62 biosynthesis protein (CbiG) GFC29_753 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GFC29_754 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GFC29_755 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GFC29_756 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GFC29_757 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GFC29_758 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GFC29_759 ENOG4105WMR Protein CrcB homolog GFC29_76 ENOG4105KVH Transcriptional regulator GFC29_760 ENOG4105WMR Protein CrcB homolog GFC29_761 ENOG4105CVG Homoserine O-transsuccinylase GFC29_764 ENOG4108V06 Glutathione peroxidase GFC29_769 ENOG4108Y6J UPF0403 protein GFC29_77 ENOG4105F27 Major Facilitator GFC29_770 ENOG4107YX5 Pfam:DUF548 GFC29_772 ENOG4105CHM Aminotransferase GFC29_773 ENOG4106E8G GFC29_774 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GFC29_775 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GFC29_777 ENOG4105C7B Threonine dehydratase GFC29_779 ENOG4108RCR degv family GFC29_78 ENOG4105CV8 reductase GFC29_780 ENOG4108KF3 Electron transport protein SCO1 SenC GFC29_781 ENOG41090WU lipolytic protein G-D-S-L family GFC29_783 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GFC29_784 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GFC29_785 ENOG4108R5S membrane GFC29_787 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GFC29_788 ENOG4108SAX Membrane GFC29_80 ENOG4105WH1 Two component transcriptional regulator luxr family GFC29_804 ENOG4105H20 Sporulation integral membrane protein YlbJ GFC29_805 ENOG4105CKI cobalamin synthesis protein GFC29_806 ENOG4108PJD permease GFC29_81 ENOG4105ENE Histidine kinase GFC29_810 ENOG4105K4P CoA-binding domain protein GFC29_811 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GFC29_814 ENOG4105C5Y PTS System GFC29_815 ENOG4105C5Y PTS System GFC29_816 ENOG4105C5Y PTS System GFC29_817 ENOG4105CG3 alpha amylase, catalytic region GFC29_818 ENOG4107414 GntR family transcriptional regulator GFC29_819 ENOG4107S6Z Na H antiporter GFC29_822 ENOG4105FDT acyl-CoA dehydrogenase GFC29_823 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GFC29_825 ENOG4105KPV Transcriptional regulator GFC29_826 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GFC29_827 ENOG4105E0X reductase GFC29_828 ENOG4105CIY formyltetrahydrofolate deformylase GFC29_830 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GFC29_831 ENOG4107T89 von Willebrand factor, type A GFC29_838 ENOG4105KD7 acetyltransferase GFC29_840 ENOG4105EC3 peptidase S51, dipeptidase E GFC29_848 ENOG4108UXE Protein tyrosine phosphatase GFC29_849 ENOG4105D6J arsenicaL-resistance protein GFC29_85 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GFC29_850 ENOG41082YX Transcriptional regulator, arsr family GFC29_854 ENOG4108IG5 Transcriptional regulator GFC29_855 ENOG4105EYF MMPL domain protein GFC29_856 ENOG41062JF Transcriptional regulator GFC29_86 ENOG4108N3W hemolysin secretion protein GFC29_861 ENOG4108J2R molybdopterin oxidoreductase GFC29_862 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GFC29_863 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GFC29_864 ENOG4105E0C molybdate abc transporter GFC29_865 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GFC29_869 ENOG4107TXC Transcriptional regulator GFC29_874 ENOG4105BZ1 (ABC) transporter GFC29_875 ENOG4105BZ1 (ABC) transporter GFC29_879 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GFC29_881 ENOG4105CRW Short chain fatty acid transporter GFC29_884 ENOG4108HHA Transketolase GFC29_887 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GFC29_893 ENOG4105D8V Glucose sorbosone dehydrogenase GFC29_897 ENOG4108VGI doxx family GFC29_898 ENOG4108TVJ Nitroreductase GFC29_900 ENOG4105C9U ATP-dependent DNA helicase RecQ GFC29_901 ENOG4105E1F short-chain dehydrogenase reductase GFC29_907 ENOG4105DKW ABC transporter GFC29_911 ENOG4105C8Q Methyl-accepting chemotaxis GFC29_912 ENOG4105D58 Diguanylate phosphodiesterase GFC29_913 ENOG4108SU4 UPF0309 protein GFC29_915 ENOG4105FDP GntR family transcriptional regulator GFC29_916 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GFC29_917 ENOG4105CE4 GlcNAc 6-P deacetylase GFC29_929 ENOG4105BZ1 (ABC) transporter GFC29_930 ENOG4105BZ1 (ABC) transporter GFC29_934 ENOG4108PCN EamA-like transporter family GFC29_935 ENOG4107V2S Transcriptional regulator GFC29_936 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GFC29_937 ENOG4108UW5 maltose o-acetyltransferase GFC29_938 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GFC29_940 ENOG4105D5Q Arginine ornithine antiporter GFC29_941 ENOG4105C7S Dehydrogenase GFC29_942 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GFC29_944 ENOG4105DEN Luciferase family GFC29_945 ENOG4107SWG transcriptional regulator MERR family GFC29_946 ENOG4105DXB Major Facilitator superfamily GFC29_948 ENOG4108IPJ Membrane GFC29_949 ENOG4108Z0Z intracellular protease Pfpi family GFC29_950 ENOG4105C59 p-type ATPase GFC29_951 ENOG4105C59 p-type ATPase GFC29_952 ENOG4105VPX protein, conserved in bacteria GFC29_954 ENOG41082BM Transcriptional regulator, arsr family GFC29_957 ENOG4105SX7 Transporter GFC29_958 ENOG4105P8F nudix hydrolase GFC29_959 ENOG4108TU7 Inherit from COG: (ABC) transporter GFC29_960 ENOG4105CJ1 ABC, transporter GFC29_961 ENOG41090WU lipolytic protein G-D-S-L family GFC29_963 ENOG41080HJ 6-phospho 3-hexuloisomerase GFC29_964 ENOG4108VA3 3-hexulose-6-phosphate synthase GFC29_967 ENOG4105D7K pfkb domain protein GFC29_969 ENOG410635A Membrane GFC29_973 ENOG4108RPX mosc domain containing protein GFC29_974 ENOG4105BZ1 (ABC) transporter GFC29_975 ENOG4105BZ1 (ABC) transporter GFC29_982 ENOG4105DVE abc transporter atp-binding protein GFC29_983 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GFC29_984 ENOG4108HGU Histidine kinase GFC29_989 ENOG4105CJ1 ABC, transporter GFC29_991 ENOG4108UZ3 Transporter GFC29_998 ENOG4105C0R drug resistance transporter emrb qaca subfamily GFC29_999 ENOG4105CW7 secretion protein, HlyD family