locus-tag	class	description
FRZ59_00020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRZ59_00075	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FRZ59_00080	COG4935	Belongs to the peptidase S8 family
FRZ59_00080	COG2234	aminopeptidase activity
FRZ59_00095	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRZ59_00095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRZ59_00100	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRZ59_00110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FRZ59_00125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FRZ59_00140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FRZ59_00145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FRZ59_00155	COG1764	response to oxidative stress
FRZ59_00165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FRZ59_00170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRZ59_00175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRZ59_00175	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FRZ59_00205	COG0626	cystathionine gamma-synthase activity
FRZ59_00265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRZ59_00295	COG4206	TonB-dependent receptor
FRZ59_00295	COG1629	transport
FRZ59_00305	COG2514	catechol 2,3-dioxygenase activity
FRZ59_00335	COG0205	6-phosphofructokinase activity
FRZ59_00345	COG0793	Belongs to the peptidase S41A family
FRZ59_00345	COG4946	Tricorn protease homolog
FRZ59_00355	COG2366	antibiotic biosynthetic process
FRZ59_00405	COG0004	ammonium transporteR
FRZ59_00410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRZ59_00420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRZ59_00430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRZ59_00460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FRZ59_00475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRZ59_00490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRZ59_00495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRZ59_00500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRZ59_00520	COG2001	Belongs to the MraZ family
FRZ59_00525	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FRZ59_00545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRZ59_00555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRZ59_00565	COG2267	carboxylic ester hydrolase activity
FRZ59_00590	COG2226	methyltransferase
FRZ59_00605	COG0577	efflux transmembrane transporter activity
FRZ59_00615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FRZ59_00620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRZ59_00635	COG0531	amino acid
FRZ59_00675	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRZ59_00680	COG0739	heme binding
FRZ59_00685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRZ59_00705	COG3959	Transketolase, thiamine diphosphate binding domain
FRZ59_00710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FRZ59_00715	COG1595	DNA-templated transcription, initiation
FRZ59_00730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FRZ59_00740	COG0509	glycine decarboxylation via glycine cleavage system
FRZ59_00785	COG1388	LysM domain
FRZ59_00785	COG0741	lytic transglycosylase activity
FRZ59_00790	COG0154	amidase activity
FRZ59_00795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRZ59_00800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRZ59_00805	COG0739	heme binding
FRZ59_00820	COG0756	dUTP diphosphatase activity
FRZ59_00830	COG1254	Belongs to the acylphosphatase family
FRZ59_00835	COG0402	S-adenosylhomocysteine deaminase activity
FRZ59_00840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FRZ59_00855	COG0463	Glycosyl transferase, family 2
FRZ59_00865	COG0423	glycine-tRNA ligase activity
FRZ59_00870	COG1131	(ABC) transporter
FRZ59_00895	COG3186	Phenylalanine-4-hydroxylase
FRZ59_00905	COG4221	oxidoreductase activity
FRZ59_00915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRZ59_00930	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FRZ59_00945	COG2207	Transcriptional regulator
FRZ59_00945	COG0662	Cupin 2, conserved barrel domain protein
FRZ59_00950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRZ59_00955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRZ59_00965	COG0138	bifunctional purine biosynthesis protein purh
FRZ59_00970	COG1077	Cell shape determining protein MreB Mrl
FRZ59_00990	COG0772	Belongs to the SEDS family
FRZ59_01000	COG2261	transglycosylase associated protein
FRZ59_01005	COG2259	Doxx family
FRZ59_01035	COG1629	transport
FRZ59_01035	COG4206	TonB-dependent receptor
FRZ59_01040	COG1082	Xylose isomerase domain protein TIM barrel
FRZ59_01045	COG0673	inositol 2-dehydrogenase activity
FRZ59_01065	COG1819	glycosyl
FRZ59_01095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRZ59_01100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRZ59_01115	COG2885	chlorophyll binding
FRZ59_01155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRZ59_01165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRZ59_01165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRZ59_01200	COG3279	Response regulator of the LytR AlgR family
FRZ59_01220	COG4206	TonB-dependent receptor
FRZ59_01220	COG1629	transport
FRZ59_01235	COG4771	TonB-dependent receptor
FRZ59_01260	COG0738	Major facilitator superfamily
FRZ59_01280	COG4206	TonB-dependent receptor
FRZ59_01280	COG1629	transport
FRZ59_01295	COG0129	dihydroxy-acid dehydratase activity
FRZ59_01310	COG0367	asparagine synthase
FRZ59_01315	COG0540	Belongs to the ATCase OTCase family
FRZ59_01335	COG1139	Iron-sulfur cluster binding protein
FRZ59_01340	COG0667	Aldo Keto reductase
FRZ59_01385	COG0022	dehydrogenase e1 component
FRZ59_01405	COG0714	Associated with various cellular activities
FRZ59_01410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRZ59_01445	COG1629	transport
FRZ59_01445	COG4206	TonB-dependent receptor
FRZ59_01465	COG0037	tRNA processing
FRZ59_01475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FRZ59_01485	COG1902	pentaerythritol trinitrate reductase activity
FRZ59_01495	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FRZ59_01500	COG3119	arylsulfatase activity
FRZ59_01520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRZ59_01540	COG0303	'Molybdopterin
FRZ59_01545	COG0315	cyclic pyranopterin monophosphate synthase activity
FRZ59_01545	COG0746	molybdenum cofactor guanylyltransferase activity
FRZ59_01550	COG0746	molybdenum cofactor guanylyltransferase activity
FRZ59_01570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRZ59_01575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FRZ59_01585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRZ59_01590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRZ59_01590	COG2146	nitrite reductase [NAD(P)H] activity
FRZ59_01600	COG4585	Histidine kinase
FRZ59_01605	COG2197	response regulator
FRZ59_01610	COG2223	nitrite transmembrane transporter activity
FRZ59_01625	COG0322	excinuclease ABC activity
FRZ59_01630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FRZ59_01665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRZ59_01670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRZ59_01675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRZ59_01680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRZ59_01685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRZ59_01710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRZ59_01710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRZ59_01725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FRZ59_01730	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FRZ59_01735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRZ59_01750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRZ59_01755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FRZ59_01760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRZ59_01770	COG1381	Involved in DNA repair and RecF pathway recombination
FRZ59_01775	COG2169	Transcriptional regulator
FRZ59_01780	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRZ59_01790	COG1215	transferase activity, transferring glycosyl groups
FRZ59_01795	COG1215	transferase activity, transferring glycosyl groups
FRZ59_01805	COG1216	Glycosyl transferase, family 2
FRZ59_01805	COG0463	Glycosyl transferase, family 2
FRZ59_01840	COG1959	2 iron, 2 sulfur cluster binding
FRZ59_01840	COG1295	ribonuclease BN
FRZ59_01865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRZ59_01875	COG0738	Major facilitator superfamily
FRZ59_01890	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_01935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRZ59_01940	COG1556	Lactate utilization protein
FRZ59_01955	COG3250	beta-galactosidase activity
FRZ59_02000	COG1629	transport
FRZ59_02000	COG4206	TonB-dependent receptor
FRZ59_02015	COG3119	arylsulfatase activity
FRZ59_02040	COG3437	response regulator, receiver
FRZ59_02050	COG1609	Transcriptional regulator
FRZ59_02065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FRZ59_02070	COG4206	TonB-dependent receptor
FRZ59_02070	COG1629	transport
FRZ59_02085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRZ59_02090	COG3938	Belongs to the proline racemase family
FRZ59_02095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRZ59_02105	COG0673	inositol 2-dehydrogenase activity
FRZ59_02115	COG2207	Transcriptional regulator
FRZ59_02115	COG0662	Cupin 2, conserved barrel domain protein
FRZ59_02125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRZ59_02140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRZ59_02145	COG0791	NLP P60 protein
FRZ59_02175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FRZ59_02190	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRZ59_02205	COG0745	RESPONSE REGULATOR receiver
FRZ59_02210	COG5002	protein histidine kinase activity
FRZ59_02250	COG2322	membrane
FRZ59_02270	COG1845	cytochrome c oxidase, subunit III
FRZ59_02275	COG0109	protoheme IX farnesyltransferase activity
FRZ59_02285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRZ59_02315	COG0437	4 iron, 4 sulfur cluster binding
FRZ59_02360	COG0792	nuclease activity
FRZ59_02365	COG0321	lipoyl(octanoyl) transferase activity
FRZ59_02375	COG2373	Large extracellular alpha-helical protein
FRZ59_02385	COG0459	protein refolding
FRZ59_02390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRZ59_02410	COG3604	Transcriptional regulator
FRZ59_02415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRZ59_02440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRZ59_02445	COG0166	Belongs to the GPI family
FRZ59_02450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FRZ59_02460	COG1349	DNA-binding transcription factor activity
FRZ59_02480	COG4206	TonB-dependent receptor
FRZ59_02480	COG1629	transport
FRZ59_02485	COG4975	Glucose uptake
FRZ59_02505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FRZ59_02510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRZ59_02525	COG0358	DNA primase activity
FRZ59_02540	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FRZ59_02550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FRZ59_02565	COG0653	protein targeting
FRZ59_02620	COG2204	response regulator
FRZ59_02625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRZ59_02625	COG2205	protein histidine kinase activity
FRZ59_02635	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRZ59_02640	COG3387	PFAM Glycoside hydrolase 15-related
FRZ59_02650	COG2207	Transcriptional regulator
FRZ59_02650	COG1609	Transcriptional regulator
FRZ59_02665	COG2274	protein secretion by the type I secretion system
FRZ59_02695	COG3386	PFAM SMP-30 Gluconolaconase
FRZ59_02705	COG3291	Pkd domain containing protein
FRZ59_02730	COG3254	rhamnose metabolic process
FRZ59_02740	COG0673	inositol 2-dehydrogenase activity
FRZ59_02780	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FRZ59_02785	COG2755	lipolytic protein G-D-S-L family
FRZ59_02785	COG0657	acetylesterase activity
FRZ59_02800	COG4206	TonB-dependent receptor
FRZ59_02800	COG1629	transport
FRZ59_02820	COG0673	inositol 2-dehydrogenase activity
FRZ59_02845	COG4952	isomerase
FRZ59_02870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRZ59_02875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRZ59_02880	COG0195	Participates in both transcription termination and antitermination
FRZ59_02885	COG0779	Required for maturation of 30S ribosomal subunits
FRZ59_02905	COG1960	acyl-CoA dehydrogenase activity
FRZ59_02920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FRZ59_02920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FRZ59_02930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FRZ59_02935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FRZ59_02950	COG1609	Transcriptional regulator
FRZ59_02955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRZ59_02960	COG0590	tRNA wobble adenosine to inosine editing
FRZ59_02970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRZ59_02975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRZ59_02975	COG3153	acetyltransferase
FRZ59_02980	COG0783	Belongs to the Dps family
FRZ59_03000	COG0708	Exodeoxyribonuclease III
FRZ59_03010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRZ59_03015	COG0673	inositol 2-dehydrogenase activity
FRZ59_03020	COG0546	phosphoglycolate phosphatase activity
FRZ59_03035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRZ59_03065	COG3239	Fatty acid desaturase
FRZ59_03095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRZ59_03100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FRZ59_03100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRZ59_03105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRZ59_03120	COG0802	atpase or kinase
FRZ59_03125	COG0686	Belongs to the AlaDH PNT family
FRZ59_03130	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRZ59_03135	COG0156	8-amino-7-oxononanoate synthase activity
FRZ59_03140	COG2027	D-alanyl-D-alanine carboxypeptidase
FRZ59_03145	COG0750	zinc metalloprotease
FRZ59_03155	COG2304	oxidoreductase activity
FRZ59_03190	COG4654	Cytochrome c, class I
FRZ59_03220	COG3119	arylsulfatase activity
FRZ59_03230	COG4206	TonB-dependent receptor
FRZ59_03230	COG1629	transport
FRZ59_03235	COG0433	COG0433 Predicted ATPase
FRZ59_03350	COG3344	reverse transcriptase
FRZ59_03390	COG0784	Response regulator, receiver
FRZ59_03390	COG2205	protein histidine kinase activity
FRZ59_03395	COG2197	response regulator
FRZ59_03400	COG2885	chlorophyll binding
FRZ59_03415	COG2197	response regulator
FRZ59_03430	COG1940	carbohydrate kinase activity
FRZ59_03465	COG4206	TonB-dependent receptor
FRZ59_03465	COG1629	transport
FRZ59_03470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRZ59_03485	COG0494	nUDIX hydrolase
FRZ59_03490	COG0204	Acyl-transferase
FRZ59_03520	COG2234	aminopeptidase activity
FRZ59_03545	COG1053	succinate dehydrogenase
FRZ59_03560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FRZ59_03575	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRZ59_03580	COG4636	protein conserved in cyanobacteria
FRZ59_03590	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FRZ59_03605	COG0302	gtp cyclohydrolase
FRZ59_03625	COG0612	Peptidase, M16
FRZ59_03635	COG0363	glucosamine-6-phosphate deaminase activity
FRZ59_03640	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FRZ59_03645	COG1349	DNA-binding transcription factor activity
FRZ59_03650	COG1629	transport
FRZ59_03650	COG4206	TonB-dependent receptor
FRZ59_03660	COG3876	Protein conserved in bacteria
FRZ59_03670	COG3275	phosphorelay sensor kinase activity
FRZ59_03690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRZ59_03695	COG0791	NLP P60 protein
FRZ59_03700	COG0668	transmembrane transport
FRZ59_03710	COG0667	Aldo Keto reductase
FRZ59_03720	COG3119	arylsulfatase activity
FRZ59_03730	COG0492	ferredoxin-NADP+ reductase activity
FRZ59_03740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRZ59_03760	COG3023	N-Acetylmuramoyl-L-alanine amidase
FRZ59_03765	COG2321	neutral zinc metallopeptidase
FRZ59_03775	COG2807	transmembrane transport
FRZ59_03805	COG1793	dna ligase
FRZ59_03820	COG0629	single-stranded DNA binding
FRZ59_03830	COG2169	Transcriptional regulator
FRZ59_03840	COG1629	transport
FRZ59_03840	COG4206	TonB-dependent receptor
FRZ59_03850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRZ59_03855	COG0228	four-way junction DNA binding
FRZ59_03860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRZ59_03870	COG0336	Belongs to the RNA methyltransferase TrmD family
FRZ59_03875	COG0335	large ribosomal subunit rRNA binding
FRZ59_03880	COG0668	transmembrane transport
FRZ59_03885	COG0688	phosphatidylethanolamine metabolic process
FRZ59_03900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRZ59_03920	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FRZ59_03925	COG3119	arylsulfatase activity
FRZ59_03930	COG1301	dicarboxylic acid transport
FRZ59_03935	COG1538	Outer membrane efflux protein
FRZ59_03945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRZ59_03965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FRZ59_03975	COG0445	tRNA wobble uridine modification
FRZ59_03980	COG0702	epimerase
FRZ59_03985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRZ59_04015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRZ59_04020	COG0640	Transcriptional regulator
FRZ59_04035	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FRZ59_04050	COG4585	Histidine kinase
FRZ59_04060	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FRZ59_04075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FRZ59_04080	COG1349	DNA-binding transcription factor activity
FRZ59_04085	COG4206	TonB-dependent receptor
FRZ59_04085	COG1629	transport
FRZ59_04105	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FRZ59_04110	COG4206	TonB-dependent receptor
FRZ59_04110	COG1629	transport
FRZ59_04150	COG4206	TonB-dependent receptor
FRZ59_04150	COG1629	transport
FRZ59_04185	COG4948	Mandelate Racemase Muconate Lactonizing
FRZ59_04190	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_04195	COG0673	inositol 2-dehydrogenase activity
FRZ59_04200	COG0673	inositol 2-dehydrogenase activity
FRZ59_04220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRZ59_04255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRZ59_04265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FRZ59_04285	COG3590	peptidase
FRZ59_04295	COG3511	phospholipase C
FRZ59_04300	COG3263	regulation of cellular component size
FRZ59_04380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRZ59_04395	COG1629	transport
FRZ59_04395	COG4206	TonB-dependent receptor
FRZ59_04425	COG1131	(ABC) transporter
FRZ59_04430	COG1131	(ABC) transporter
FRZ59_04435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRZ59_04470	COG0860	N-Acetylmuramoyl-L-alanine amidase
FRZ59_04485	COG2312	Erythromycin esterase
FRZ59_04515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRZ59_04520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FRZ59_04525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRZ59_04530	COG3279	Response regulator of the LytR AlgR family
FRZ59_04535	COG3275	phosphorelay sensor kinase activity
FRZ59_04550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRZ59_04560	COG0023	Translation Initiation Factor
FRZ59_04585	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FRZ59_04595	COG0457	Tetratricopeptide repeat
FRZ59_04600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_04605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_04610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_04615	COG0649	NAD binding
FRZ59_04620	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FRZ59_04630	COG1034	ATP synthesis coupled electron transport
FRZ59_04635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRZ59_04640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_04645	COG0839	Belongs to the complex I subunit 6 family
FRZ59_04650	COG0713	ATP synthesis coupled electron transport
FRZ59_04655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRZ59_04660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_04665	COG1007	ATP synthesis coupled electron transport
FRZ59_04680	COG1253	flavin adenine dinucleotide binding
FRZ59_04695	COG5016	pyruvate
FRZ59_04695	COG0511	ligase activity, forming carbon-carbon bonds
FRZ59_04715	COG2259	Doxx family
FRZ59_04720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRZ59_04720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRZ59_04785	COG1715	Restriction endonuclease
FRZ59_04820	COG1566	PFAM secretion protein HlyD family protein
FRZ59_04830	COG1191	sigma factor activity
FRZ59_04850	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRZ59_04895	COG1725	Transcriptional regulator
FRZ59_04920	COG4948	Mandelate Racemase Muconate Lactonizing
FRZ59_04935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRZ59_04940	COG0165	Argininosuccinate lyase
FRZ59_04945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRZ59_04950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRZ59_04960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRZ59_04970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FRZ59_04975	COG0137	argininosuccinate synthase activity
FRZ59_04995	COG0352	thiamine-phosphate diphosphorylase activity
FRZ59_05015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRZ59_05020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRZ59_05025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRZ59_05035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FRZ59_05045	COG1530	ribonuclease E activity
FRZ59_05055	COG0776	regulation of translation
FRZ59_05065	COG0629	single-stranded DNA binding
FRZ59_05070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRZ59_05075	COG1595	DNA-templated transcription, initiation
FRZ59_05090	COG0861	Integral membrane protein TerC family
FRZ59_05105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FRZ59_05125	COG0124	histidyl-tRNA synthetase
FRZ59_05130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRZ59_05145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRZ59_05145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRZ59_05150	COG0519	Catalyzes the synthesis of GMP from XMP
FRZ59_05155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRZ59_05165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRZ59_05185	COG3852	Histidine kinase
FRZ59_05190	COG0784	Response regulator, receiver
FRZ59_05195	COG4251	negative regulation of phosphorylation
FRZ59_05200	COG4251	negative regulation of phosphorylation
FRZ59_05215	COG1024	Enoyl-CoA hydratase
FRZ59_05220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRZ59_05220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRZ59_05270	COG0714	Associated with various cellular activities
FRZ59_05280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRZ59_05285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRZ59_05290	COG3852	Histidine kinase
FRZ59_05300	COG4771	TonB-dependent receptor
FRZ59_05345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRZ59_05355	COG2379	hydroxypyruvate reductase
FRZ59_05385	COG3391	amine dehydrogenase activity
FRZ59_05390	COG3275	phosphorelay sensor kinase activity
FRZ59_05425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FRZ59_05440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRZ59_05445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRZ59_05475	COG2814	Major facilitator Superfamily
FRZ59_05485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRZ59_05495	COG3119	arylsulfatase activity
FRZ59_05500	COG3119	arylsulfatase activity
FRZ59_05520	COG0697	spore germination
FRZ59_05560	COG1741	Belongs to the pirin family
FRZ59_05575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRZ59_05625	COG4206	TonB-dependent receptor
FRZ59_05625	COG1629	transport
FRZ59_05635	COG0673	inositol 2-dehydrogenase activity
FRZ59_05650	COG1136	(ABC) transporter
FRZ59_05650	COG0577	efflux transmembrane transporter activity
FRZ59_05660	COG1917	Cupin 2, conserved barrel domain protein
FRZ59_05660	COG2207	Transcriptional regulator
FRZ59_05680	COG0577	efflux transmembrane transporter activity
FRZ59_05700	COG4206	TonB-dependent receptor
FRZ59_05700	COG1629	transport
FRZ59_05720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRZ59_05850	COG1629	transport
FRZ59_05850	COG4206	TonB-dependent receptor
FRZ59_05985	COG0456	acetyltransferase
FRZ59_06025	COG4948	Mandelate Racemase Muconate Lactonizing
FRZ59_06030	COG0667	Aldo Keto reductase
FRZ59_06055	COG4206	TonB-dependent receptor
FRZ59_06055	COG1629	transport
FRZ59_06090	COG2361	Protein of unknown function DUF86
FRZ59_06150	COG0653	protein targeting
FRZ59_06215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRZ59_06310	COG3344	reverse transcriptase
FRZ59_06335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRZ59_06345	COG1215	transferase activity, transferring glycosyl groups
FRZ59_06360	COG0438	transferase activity, transferring glycosyl groups
FRZ59_06375	COG1216	Glycosyl transferase, family 2
FRZ59_06385	COG1132	(ABC) transporter
FRZ59_06390	COG1215	transferase activity, transferring glycosyl groups
FRZ59_06420	COG0251	oxidation-reduction process
FRZ59_06425	COG2962	Rard protein
FRZ59_06435	COG0657	acetylesterase activity
FRZ59_06435	COG2755	lipolytic protein G-D-S-L family
FRZ59_06440	COG1132	(ABC) transporter
FRZ59_06445	COG0233	cytoplasmic translational termination
FRZ59_06450	COG0528	UMP kinase activity
FRZ59_06455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRZ59_06460	COG0052	Belongs to the universal ribosomal protein uS2 family
FRZ59_06465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FRZ59_06470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRZ59_06480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FRZ59_06490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRZ59_06500	COG0134	indole-3-glycerol-phosphate synthase activity
FRZ59_06505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRZ59_06505	COG0512	Glutamine amidotransferase of anthranilate synthase
FRZ59_06520	COG1228	amidohydrolase
FRZ59_06525	COG1522	sequence-specific DNA binding
FRZ59_06535	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRZ59_06535	COG0022	dehydrogenase e1 component
FRZ59_06540	COG0210	DNA helicase
FRZ59_06565	COG1629	transport
FRZ59_06565	COG4206	TonB-dependent receptor
FRZ59_06570	COG1472	Belongs to the glycosyl hydrolase 3 family
FRZ59_06595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRZ59_06600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRZ59_06605	COG0571	ribonuclease III activity
FRZ59_06615	COG0194	GDP metabolic process
FRZ59_06620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FRZ59_06645	COG0612	Peptidase, M16
FRZ59_06655	COG1609	Transcriptional regulator
FRZ59_06660	COG4206	TonB-dependent receptor
FRZ59_06660	COG1629	transport
FRZ59_06675	COG1629	transport
FRZ59_06675	COG4206	TonB-dependent receptor
FRZ59_06685	COG4232	protein-disulfide reductase activity
FRZ59_06695	COG0205	6-phosphofructokinase activity
FRZ59_06700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FRZ59_06705	COG0606	chelatase, subunit chli
FRZ59_06730	COG4206	TonB-dependent receptor
FRZ59_06730	COG1629	transport
FRZ59_06755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRZ59_06760	COG0489	protein tyrosine kinase activity
FRZ59_06765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FRZ59_06770	COG0242	peptide deformylase activity
FRZ59_06780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRZ59_06785	COG0470	DNA polymerase III
FRZ59_06790	COG1774	PSP1 C-terminal conserved region
FRZ59_06800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRZ59_06815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRZ59_06820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRZ59_06880	COG0297	glycogen (starch) synthase activity
FRZ59_06885	COG1216	Glycosyl transferase, family 2
FRZ59_06900	COG0556	nucleotide-excision repair
FRZ59_06940	COG2885	chlorophyll binding
FRZ59_06955	COG0047	phosphoribosylformylglycinamidine synthase activity
FRZ59_06965	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FRZ59_06980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRZ59_07005	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FRZ59_07020	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FRZ59_07040	COG1215	transferase activity, transferring glycosyl groups
FRZ59_07045	COG1215	transferase activity, transferring glycosyl groups
FRZ59_07075	COG0438	transferase activity, transferring glycosyl groups
FRZ59_07080	COG0438	transferase activity, transferring glycosyl groups
FRZ59_07110	COG4464	protein tyrosine phosphatase activity
FRZ59_07135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FRZ59_07140	COG1086	Polysaccharide biosynthesis protein
FRZ59_07145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FRZ59_07155	COG2089	acid synthase
FRZ59_07160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FRZ59_07165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRZ59_07200	COG0110	maltose O-acetyltransferase activity
FRZ59_07205	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FRZ59_07220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRZ59_07240	COG3119	arylsulfatase activity
FRZ59_07250	COG1484	DNA-dependent DNA replication
FRZ59_07320	COG3273	potassium ion transport
FRZ59_07320	COG0471	metal ion transport
FRZ59_07325	COG0471	metal ion transport
FRZ59_07325	COG3273	potassium ion transport
FRZ59_07330	COG0529	Catalyzes the synthesis of activated sulfate
FRZ59_07335	COG0175	sulfate reduction
FRZ59_07360	COG2234	aminopeptidase activity
FRZ59_07365	COG0698	ribose 5-phosphate isomerase
FRZ59_07370	COG0805	protein transport
FRZ59_07375	COG0439	Biotin carboxylase
FRZ59_07380	COG0511	ligase activity, forming carbon-carbon bonds
FRZ59_07385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRZ59_07390	COG0416	fatty acid biosynthetic process
FRZ59_07395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRZ59_07405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FRZ59_07410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRZ59_07415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRZ59_07430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRZ59_07470	COG3119	arylsulfatase activity
FRZ59_07475	COG3119	arylsulfatase activity
FRZ59_07480	COG1609	Transcriptional regulator
FRZ59_07485	COG4206	TonB-dependent receptor
FRZ59_07485	COG1629	transport
FRZ59_07490	COG1629	transport
FRZ59_07490	COG4206	TonB-dependent receptor
FRZ59_07555	COG0673	inositol 2-dehydrogenase activity
FRZ59_07570	COG0363	glucosamine-6-phosphate deaminase activity
FRZ59_07580	COG2721	sulfolactate sulfo-lyase activity
FRZ59_07600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FRZ59_07610	COG1215	transferase activity, transferring glycosyl groups
FRZ59_07615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRZ59_07620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FRZ59_07625	COG2045	Belongs to the ComB family
FRZ59_07630	COG1694	Mazg nucleotide pyrophosphohydrolase
FRZ59_07640	COG1490	D-aminoacyl-tRNA deacylase activity
FRZ59_07650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FRZ59_07670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRZ59_07675	COG0573	inorganic phosphate transmembrane transporter activity
FRZ59_07680	COG0581	inorganic phosphate transmembrane transporter activity
FRZ59_07685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRZ59_07690	COG0704	Plays a role in the regulation of phosphate uptake
FRZ59_07700	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FRZ59_07705	COG0793	Belongs to the peptidase S41A family
FRZ59_07715	COG1160	GTP binding
FRZ59_07720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRZ59_07770	COG0702	epimerase
FRZ59_07785	COG1312	Catalyzes the dehydration of D-mannonate
FRZ59_07800	COG0800	Aldolase
FRZ59_07810	COG1904	glucuronate isomerase
FRZ59_07815	COG0246	Mannitol dehydrogenase
FRZ59_07840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRZ59_07845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRZ59_07850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRZ59_07860	COG0405	Gamma-glutamyltransferase
FRZ59_07870	COG0183	Belongs to the thiolase family
FRZ59_07875	COG1960	acyl-CoA dehydrogenase activity
FRZ59_07885	COG0460	homoserine dehydrogenase
FRZ59_07885	COG0527	aspartate kinase activity
FRZ59_07890	COG0083	homoserine kinase activity
FRZ59_07900	COG0545	Peptidyl-prolyl cis-trans isomerase
FRZ59_07910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRZ59_07930	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRZ59_07965	COG1007	ATP synthesis coupled electron transport
FRZ59_07970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_07975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRZ59_07980	COG0713	ATP synthesis coupled electron transport
FRZ59_07990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_07995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRZ59_08025	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_08030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_08055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FRZ59_08060	COG1595	DNA-templated transcription, initiation
FRZ59_08080	COG0215	cysteine-tRNA ligase activity
FRZ59_08100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRZ59_08105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRZ59_08110	COG0438	transferase activity, transferring glycosyl groups
FRZ59_08115	COG1187	pseudouridine synthase activity
FRZ59_08140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FRZ59_08145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRZ59_08150	COG1040	competence protein
FRZ59_08160	COG0268	Binds directly to 16S ribosomal RNA
FRZ59_08165	COG2003	Belongs to the UPF0758 family
FRZ59_08190	COG1418	mRNA catabolic process
FRZ59_08215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FRZ59_08220	COG1960	acyl-CoA dehydrogenase activity
FRZ59_08230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FRZ59_08235	COG4974	Belongs to the 'phage' integrase family
FRZ59_08285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRZ59_08290	COG0081	regulation of translation
FRZ59_08295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRZ59_08300	COG0222	ribosome binding
FRZ59_08305	COG0085	RNA polymerase activity
FRZ59_08310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRZ59_08320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRZ59_08335	COG0617	tRNA 3'-terminal CCA addition
FRZ59_08355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FRZ59_08365	COG0187	DNA topoisomerase II activity
FRZ59_08380	COG0039	L-malate dehydrogenase activity
FRZ59_08410	COG3344	reverse transcriptase
FRZ59_08430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRZ59_08435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRZ59_08440	COG2186	Transcriptional regulator
FRZ59_08450	COG1629	transport
FRZ59_08450	COG4206	TonB-dependent receptor
FRZ59_08455	COG0561	phosphatase activity
FRZ59_08460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRZ59_08465	COG0445	tRNA wobble uridine modification
FRZ59_08480	COG3119	arylsulfatase activity
FRZ59_08485	COG3119	arylsulfatase activity
FRZ59_08505	COG4206	TonB-dependent receptor
FRZ59_08505	COG1629	transport
FRZ59_08535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRZ59_08545	COG4206	TonB-dependent receptor
FRZ59_08545	COG1629	transport
FRZ59_08590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRZ59_08595	COG2186	Transcriptional regulator
FRZ59_08600	COG3119	arylsulfatase activity
FRZ59_08620	COG4206	TonB-dependent receptor
FRZ59_08620	COG1629	transport
FRZ59_08650	COG1629	transport
FRZ59_08650	COG4206	TonB-dependent receptor
FRZ59_08665	COG3119	arylsulfatase activity
FRZ59_08670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRZ59_08685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRZ59_08690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRZ59_08695	COG0598	Magnesium transport protein CorA
FRZ59_08775	COG2814	Major facilitator Superfamily
FRZ59_08780	COG2207	Transcriptional regulator
FRZ59_08780	COG1917	Cupin 2, conserved barrel domain protein
FRZ59_08800	COG4206	TonB-dependent receptor
FRZ59_08800	COG1629	transport
FRZ59_08815	COG4206	TonB-dependent receptor
FRZ59_08815	COG1629	transport
FRZ59_08865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FRZ59_08895	COG1058	Belongs to the CinA family
FRZ59_08895	COG1546	Belongs to the CinA family
FRZ59_08905	COG3685	Protein conserved in bacteria
FRZ59_08915	COG0577	efflux transmembrane transporter activity
FRZ59_08985	COG0463	Glycosyl transferase, family 2
FRZ59_08990	COG0463	Glycosyl transferase, family 2
FRZ59_09000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRZ59_09050	COG0577	efflux transmembrane transporter activity
FRZ59_09065	COG0673	inositol 2-dehydrogenase activity
FRZ59_09075	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_09115	COG0825	malonyl-CoA metabolic process
FRZ59_09130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRZ59_09135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FRZ59_09140	COG0193	aminoacyl-tRNA hydrolase activity
FRZ59_09160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRZ59_09170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRZ59_09175	COG2027	D-alanyl-D-alanine carboxypeptidase
FRZ59_09200	COG1629	transport
FRZ59_09200	COG4206	TonB-dependent receptor
FRZ59_09220	COG1595	DNA-templated transcription, initiation
FRZ59_09255	COG1966	Carbon starvation protein
FRZ59_09290	COG0436	Aminotransferase
FRZ59_09305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FRZ59_09310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FRZ59_09315	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FRZ59_09320	COG0077	Prephenate dehydratase
FRZ59_09320	COG1605	Chorismate mutase
FRZ59_09325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FRZ59_09335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRZ59_09340	COG0552	protein localization to endoplasmic reticulum
FRZ59_09350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRZ59_09355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRZ59_09365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRZ59_09375	COG4221	oxidoreductase activity
FRZ59_09380	COG0471	metal ion transport
FRZ59_09380	COG3273	potassium ion transport
FRZ59_09390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRZ59_09400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRZ59_09440	COG1629	transport
FRZ59_09440	COG4206	TonB-dependent receptor
FRZ59_09455	COG0071	Belongs to the small heat shock protein (HSP20) family
FRZ59_09485	COG3119	arylsulfatase activity
FRZ59_09520	COG1629	transport
FRZ59_09520	COG4206	TonB-dependent receptor
FRZ59_09530	COG2801	Transposase and inactivated derivatives
FRZ59_09545	COG4095	Psort location CytoplasmicMembrane, score
FRZ59_09595	COG3119	arylsulfatase activity
FRZ59_09610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRZ59_09615	COG4232	protein-disulfide reductase activity
FRZ59_09650	COG2217	Heavy metal translocating P-type atpase
FRZ59_09680	COG5564	TIM-barrel signal transduction protein
FRZ59_09690	COG0471	metal ion transport
FRZ59_09700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FRZ59_09710	COG4206	TonB-dependent receptor
FRZ59_09710	COG1629	transport
FRZ59_09720	COG1629	transport
FRZ59_09720	COG4206	TonB-dependent receptor
FRZ59_09750	COG4804	nuclease activity
FRZ59_09760	COG0196	riboflavin kinase activity
FRZ59_09765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRZ59_09770	COG1968	undecaprenyl-diphosphatase activity
FRZ59_09780	COG2177	Part of the ABC transporter FtsEX involved in
FRZ59_09785	COG0495	leucyl-tRNA aminoacylation
FRZ59_09790	COG1609	Transcriptional regulator
FRZ59_09795	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FRZ59_09800	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FRZ59_09810	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_09835	COG1278	Cold shock
FRZ59_09840	COG1363	Peptidase, m42
FRZ59_09845	COG0740	serine-type endopeptidase activity
FRZ59_09855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRZ59_09860	COG0745	RESPONSE REGULATOR receiver
FRZ59_09870	COG0659	secondary active sulfate transmembrane transporter activity
FRZ59_09875	COG0288	reversible hydration of carbon dioxide
FRZ59_09890	COG1047	Peptidyl-prolyl cis-trans
FRZ59_09900	COG1663	tetraacyldisaccharide 4'-kinase activity
FRZ59_09910	COG3537	Alpha-1,2-mannosidase
FRZ59_09925	COG1131	(ABC) transporter
FRZ59_09935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRZ59_09955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FRZ59_09975	COG0726	polysaccharide deacetylase
FRZ59_09980	COG4191	Histidine kinase
FRZ59_09995	COG1136	(ABC) transporter
FRZ59_09995	COG0577	efflux transmembrane transporter activity
FRZ59_10040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRZ59_10045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRZ59_10050	COG2010	Cytochrome c
FRZ59_10060	COG0577	efflux transmembrane transporter activity
FRZ59_10060	COG1136	(ABC) transporter
FRZ59_10070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRZ59_10085	COG1045	serine acetyltransferase
FRZ59_10095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FRZ59_10100	COG1278	Cold shock
FRZ59_10105	COG0513	Belongs to the DEAD box helicase family
FRZ59_10110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FRZ59_10115	COG1522	sequence-specific DNA binding
FRZ59_10130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FRZ59_10160	COG0668	transmembrane transport
FRZ59_10170	COG1621	beta-fructofuranosidase activity
FRZ59_10195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRZ59_10200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRZ59_10220	COG2610	gluconate transmembrane transporter activity
FRZ59_10255	COG3275	phosphorelay sensor kinase activity
FRZ59_10260	COG3275	phosphorelay sensor kinase activity
FRZ59_10295	COG1629	transport
FRZ59_10295	COG4206	TonB-dependent receptor
FRZ59_10300	COG2207	Transcriptional regulator
FRZ59_10300	COG1917	Cupin 2, conserved barrel domain protein
FRZ59_10305	COG1063	alcohol dehydrogenase
FRZ59_10315	COG0673	inositol 2-dehydrogenase activity
FRZ59_10320	COG1335	isochorismatase
FRZ59_10335	COG1011	Hydrolase
FRZ59_10340	COG1022	Amp-dependent synthetase and ligase
FRZ59_10345	COG0316	Belongs to the HesB IscA family
FRZ59_10350	COG1104	cysteine desulfurase activity
FRZ59_10355	COG0346	lactoylglutathione lyase activity
FRZ59_10365	COG0254	rRNA binding
FRZ59_10375	COG0149	triose-phosphate isomerase activity
FRZ59_10380	COG2264	protein methyltransferase activity
FRZ59_10385	COG1674	ftsk spoiiie
FRZ59_10400	COG0321	lipoyl(octanoyl) transferase activity
FRZ59_10400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FRZ59_10425	COG0386	Belongs to the glutathione peroxidase family
FRZ59_10455	COG0424	maF-like protein
FRZ59_10470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRZ59_10470	COG0519	Catalyzes the synthesis of GMP from XMP
FRZ59_10480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FRZ59_10480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRZ59_10485	COG0217	transcriptional regulatory protein
FRZ59_10490	COG2095	MarC family integral membrane protein
FRZ59_10495	COG0531	amino acid
FRZ59_10525	COG0848	biopolymer transport protein
FRZ59_10530	COG0811	peptide transport
FRZ59_10555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FRZ59_10565	COG2183	response to ionizing radiation
FRZ59_10565	COG0539	negative regulation of cytoplasmic translation
FRZ59_10585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FRZ59_10600	COG0439	Biotin carboxylase
FRZ59_10610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRZ59_10625	COG0706	membrane insertase activity
FRZ59_10635	COG0673	inositol 2-dehydrogenase activity
FRZ59_10650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FRZ59_10655	COG1428	Deoxynucleoside kinase
FRZ59_10660	COG0180	Tryptophanyl-tRNA synthetase
FRZ59_10670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRZ59_10675	COG1136	(ABC) transporter
FRZ59_10695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FRZ59_10700	COG0577	efflux transmembrane transporter activity
FRZ59_10715	COG1629	transport
FRZ59_10715	COG4206	TonB-dependent receptor
FRZ59_10720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FRZ59_10735	COG1629	transport
FRZ59_10735	COG4206	TonB-dependent receptor
FRZ59_10775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FRZ59_10775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FRZ59_10790	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_10795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRZ59_10820	COG0534	Mate efflux family protein
FRZ59_10845	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FRZ59_10850	COG4584	PFAM Integrase catalytic
FRZ59_10850	COG2390	Transcriptional regulator
FRZ59_10855	COG1484	DNA-dependent DNA replication
FRZ59_10875	COG0024	Methionine aminopeptidase
FRZ59_10880	COG1136	(ABC) transporter
FRZ59_10880	COG0577	efflux transmembrane transporter activity
FRZ59_10900	COG2197	response regulator
FRZ59_10915	COG1136	(ABC) transporter
FRZ59_10915	COG0577	efflux transmembrane transporter activity
FRZ59_10995	COG2197	response regulator
FRZ59_11015	COG0514	ATP-dependent DNA helicase (RecQ)
FRZ59_11035	COG3621	Patatin-like phospholipase
FRZ59_11045	COG0577	efflux transmembrane transporter activity
FRZ59_11075	COG0126	phosphoglycerate kinase activity
FRZ59_11080	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRZ59_11095	COG0713	ATP synthesis coupled electron transport
FRZ59_11100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRZ59_11110	COG1007	ATP synthesis coupled electron transport
FRZ59_11115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FRZ59_11125	COG1607	acyl-coa hydrolase
FRZ59_11130	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRZ59_11140	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRZ59_11145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRZ59_11160	COG0167	dihydroorotate dehydrogenase activity
FRZ59_11165	COG0488	(ABC) transporter
FRZ59_11190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRZ59_11210	COG0697	spore germination
FRZ59_11220	COG0514	ATP-dependent DNA helicase (RecQ)
FRZ59_11230	COG4993	Dehydrogenase
FRZ59_11235	COG3119	arylsulfatase activity
FRZ59_11240	COG2217	Heavy metal translocating P-type atpase
FRZ59_11250	COG3734	2-keto-3-deoxy-galactonokinase
FRZ59_11270	COG3424	synthase
FRZ59_11305	COG0859	PFAM glycosyl transferase family 9
FRZ59_11310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FRZ59_11310	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FRZ59_11320	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_11325	COG0438	transferase activity, transferring glycosyl groups
FRZ59_11365	COG1201	RNA secondary structure unwinding
FRZ59_11370	COG2814	Major facilitator Superfamily
FRZ59_11380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRZ59_11400	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRZ59_11405	COG0740	serine-type endopeptidase activity
FRZ59_11410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRZ59_11420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRZ59_11455	COG1573	uracil-dna glycosylase
FRZ59_11470	COG1629	transport
FRZ59_11470	COG4206	TonB-dependent receptor
FRZ59_11495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRZ59_11525	COG0673	inositol 2-dehydrogenase activity
FRZ59_11530	COG3237	CsbD-like
FRZ59_11535	COG2201	protein-glutamate methylesterase activity
FRZ59_11540	COG4251	negative regulation of phosphorylation
FRZ59_11555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FRZ59_11565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FRZ59_11570	COG0066	3-isopropylmalate dehydratase activity
FRZ59_11575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRZ59_11580	COG0473	3-isopropylmalate dehydrogenase activity
FRZ59_11585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRZ59_11595	COG4771	TonB-dependent receptor
FRZ59_11610	COG0745	RESPONSE REGULATOR receiver
FRZ59_11615	COG4251	negative regulation of phosphorylation
FRZ59_11635	COG1266	CAAX protease self-immunity
FRZ59_11640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FRZ59_11645	COG0668	transmembrane transport
FRZ59_11655	COG1024	Enoyl-CoA hydratase
FRZ59_11660	COG0658	competence protein
FRZ59_11710	COG0739	heme binding
FRZ59_11715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRZ59_11725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRZ59_11730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRZ59_11735	COG0745	RESPONSE REGULATOR receiver
FRZ59_11740	COG5002	protein histidine kinase activity
FRZ59_11750	COG0564	pseudouridine synthase activity
FRZ59_11770	COG1166	arginine decarboxylase activity
FRZ59_11775	COG0010	Belongs to the arginase family
FRZ59_11780	COG0018	arginyl-trna synthetase
FRZ59_11790	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRZ59_11800	COG4206	TonB-dependent receptor
FRZ59_11800	COG1629	transport
FRZ59_11810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FRZ59_11815	COG0156	8-amino-7-oxononanoate synthase activity
FRZ59_11820	COG3537	Alpha-1,2-mannosidase
FRZ59_11825	COG3142	Participates in the control of copper homeostasis
FRZ59_11835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRZ59_11840	COG0525	valine-tRNA ligase activity
FRZ59_11850	COG0484	heat shock protein binding
FRZ59_11855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRZ59_11860	COG2884	Cell division ATP-binding protein ftsE
FRZ59_11885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRZ59_11895	COG0589	response to stress
FRZ59_11900	COG0604	alcohol dehydrogenase
FRZ59_11910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FRZ59_11910	COG0140	phosphoribosyl-ATP diphosphatase activity
FRZ59_11915	COG0107	imidazoleglycerol-phosphate synthase activity
FRZ59_11920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FRZ59_11925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FRZ59_11930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FRZ59_11930	COG0131	Imidazoleglycerol-phosphate dehydratase
FRZ59_11935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRZ59_11940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FRZ59_11945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FRZ59_11955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRZ59_11970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRZ59_11990	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FRZ59_11995	COG2255	four-way junction helicase activity
FRZ59_12000	COG0463	Glycosyl transferase, family 2
FRZ59_12005	COG3104	oligopeptide transport
FRZ59_12010	COG0823	Involved in the tonB-independent uptake of proteins
FRZ59_12010	COG1506	peptidase
FRZ59_12020	COG0183	Belongs to the thiolase family
FRZ59_12025	COG1480	7TM receptor with intracellular HD hydrolase
FRZ59_12040	COG0577	efflux transmembrane transporter activity
FRZ59_12095	COG2223	nitrite transmembrane transporter activity
FRZ59_12100	COG2186	Transcriptional regulator
FRZ59_12120	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_12145	COG2176	DNA-directed DNA polymerase activity
FRZ59_12155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FRZ59_12205	COG2323	membrane
FRZ59_12210	COG3685	Protein conserved in bacteria
FRZ59_12225	COG1733	regulation of RNA biosynthetic process
FRZ59_12345	COG2318	DinB family
FRZ59_12365	COG1629	transport
FRZ59_12365	COG4206	TonB-dependent receptor
FRZ59_12390	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FRZ59_12400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FRZ59_12415	COG1139	Iron-sulfur cluster binding protein
FRZ59_12425	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_12450	COG0587	DNA-directed DNA polymerase activity
FRZ59_12500	COG3119	arylsulfatase activity
FRZ59_12530	COG4206	TonB-dependent receptor
FRZ59_12530	COG1629	transport
FRZ59_12535	COG0492	ferredoxin-NADP+ reductase activity
FRZ59_12540	COG1408	metallophosphoesterase
FRZ59_12545	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_12550	COG1640	4-alpha-glucanotransferase
FRZ59_12565	COG0366	Alpha amylase catalytic
FRZ59_12570	COG0366	Alpha amylase catalytic
FRZ59_12575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FRZ59_12635	COG2188	Transcriptional regulator
FRZ59_12645	COG2814	Major facilitator Superfamily
FRZ59_12650	COG1629	transport
FRZ59_12650	COG4206	TonB-dependent receptor
FRZ59_12660	COG3537	Alpha-1,2-mannosidase
FRZ59_12665	COG0542	response to heat
FRZ59_12670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRZ59_12675	COG0494	nUDIX hydrolase
FRZ59_12680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRZ59_12685	COG0742	ribosomal rna small subunit methyltransferase
FRZ59_12695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRZ59_12700	COG1301	dicarboxylic acid transport
FRZ59_12710	COG2814	Major facilitator Superfamily
FRZ59_12720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRZ59_12725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRZ59_12730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FRZ59_12735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRZ59_12760	COG0477	Major facilitator Superfamily
FRZ59_12765	COG0408	coproporphyrinogen oxidase activity
FRZ59_12775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRZ59_12785	COG1940	carbohydrate kinase activity
FRZ59_12790	COG3757	hydrolase, family 25
FRZ59_12815	COG3956	TIGRFAM MazG family protein
FRZ59_12835	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRZ59_12840	COG1119	ATPase activity
FRZ59_12845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FRZ59_12850	COG0628	permease
FRZ59_12870	COG2706	6-phosphogluconolactonase activity
FRZ59_12900	COG0557	exoribonuclease II activity
FRZ59_12910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRZ59_12915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRZ59_12920	COG0492	ferredoxin-NADP+ reductase activity
FRZ59_12925	COG0482	sulfurtransferase activity
FRZ59_12930	COG0598	Magnesium transport protein CorA
FRZ59_12935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRZ59_12955	COG0745	RESPONSE REGULATOR receiver
FRZ59_12985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRZ59_12995	COG0028	Belongs to the TPP enzyme family
FRZ59_13000	COG0440	acetolactate synthase activity
FRZ59_13005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FRZ59_13010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRZ59_13025	COG2346	COG2346, Truncated hemoglobins
FRZ59_13040	COG2010	Cytochrome c
FRZ59_13050	COG1959	2 iron, 2 sulfur cluster binding
FRZ59_13060	COG1525	nuclease
FRZ59_13070	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_13075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FRZ59_13085	COG1132	(ABC) transporter
FRZ59_13095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRZ59_13105	COG1862	Preprotein translocase
FRZ59_13115	COG0237	dephospho-CoA kinase activity
FRZ59_13125	COG0671	phosphoesterase, PA-phosphatase related
FRZ59_13130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRZ59_13135	COG1104	cysteine desulfurase activity
FRZ59_13140	COG0191	fructose-bisphosphate aldolase activity
FRZ59_13145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FRZ59_13150	COG1830	Aldolase
FRZ59_13165	COG4771	TonB-dependent receptor
FRZ59_13175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FRZ59_13180	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_13185	COG0129	dihydroxy-acid dehydratase activity
FRZ59_13195	COG1956	GAF domain-containing protein
FRZ59_13205	COG2094	Belongs to the DNA glycosylase MPG family
FRZ59_13210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FRZ59_13220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRZ59_13235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRZ59_13245	COG1629	transport
FRZ59_13245	COG4206	TonB-dependent receptor
FRZ59_13255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FRZ59_13265	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FRZ59_13270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRZ59_13275	COG0135	phosphoribosylanthranilate isomerase activity
FRZ59_13280	COG0133	tryptophan synthase activity
FRZ59_13285	COG0159	tryptophan synthase activity
FRZ59_13290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRZ59_13295	COG0009	L-threonylcarbamoyladenylate synthase
FRZ59_13300	COG0045	succinate-CoA ligase (ADP-forming) activity
FRZ59_13310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRZ59_13310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRZ59_13315	COG2890	protein-(glutamine-N5) methyltransferase activity
FRZ59_13330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FRZ59_13335	COG4974	Belongs to the 'phage' integrase family
FRZ59_13350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FRZ59_13405	COG3279	Response regulator of the LytR AlgR family
FRZ59_13410	COG0488	(ABC) transporter
FRZ59_13415	COG2186	Transcriptional regulator
FRZ59_13430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FRZ59_13445	COG1666	GTP binding
FRZ59_13450	COG2211	Major facilitator Superfamily
FRZ59_13455	COG0673	inositol 2-dehydrogenase activity
FRZ59_13470	COG0277	FAD linked oxidase domain protein
FRZ59_13475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FRZ59_13480	COG1960	acyl-CoA dehydrogenase activity
FRZ59_13490	COG0475	glutathione-regulated potassium exporter activity
FRZ59_13490	COG0589	response to stress
FRZ59_13495	COG0019	diaminopimelate decarboxylase activity
FRZ59_13500	COG0527	aspartate kinase activity
FRZ59_13510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRZ59_13525	COG2010	Cytochrome c
FRZ59_13540	COG0481	GTPase activity
FRZ59_13545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRZ59_13550	COG0602	queuosine metabolic process
FRZ59_13555	COG2885	chlorophyll binding
FRZ59_13560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FRZ59_13565	COG0514	ATP-dependent DNA helicase (RecQ)
FRZ59_13575	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FRZ59_13575	COG0662	Cupin 2, conserved barrel domain protein
FRZ59_13585	COG0753	catalase activity
FRZ59_13590	COG2801	Transposase and inactivated derivatives
FRZ59_13600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRZ59_13605	COG0305	Participates in initiation and elongation during chromosome replication
FRZ59_13610	COG2259	Doxx family
FRZ59_13620	COG0386	Belongs to the glutathione peroxidase family
FRZ59_13640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRZ59_13655	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FRZ59_13665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FRZ59_13675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRZ59_13685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRZ59_13705	COG1196	nuclear chromosome segregation
FRZ59_13715	COG4221	oxidoreductase activity
FRZ59_13720	COG1629	transport
FRZ59_13720	COG4206	TonB-dependent receptor
FRZ59_13735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRZ59_13745	COG1611	Belongs to the LOG family
FRZ59_13760	COG0673	inositol 2-dehydrogenase activity
FRZ59_13765	COG4953	penicillin-binding protein 1C
FRZ59_13790	COG0516	GMP reductase activity
FRZ59_13790	COG0517	IMP dehydrogenase activity
FRZ59_13795	COG0004	ammonium transporteR
FRZ59_13800	COG0758	DNA mediated transformation
FRZ59_13805	COG0357	Ribosomal RNA small subunit methyltransferase G
FRZ59_13815	COG0343	queuine tRNA-ribosyltransferase activity
FRZ59_13845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRZ59_13855	COG0066	3-isopropylmalate dehydratase activity
FRZ59_13860	COG0719	Fe-S assembly protein
FRZ59_13865	COG0396	ATPase activity
FRZ59_13870	COG0719	Fe-S assembly protein
FRZ59_13875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRZ59_13880	COG2166	iron-sulfur cluster assembly
FRZ59_13885	COG2151	metal-sulfur cluster biosynthetic enzyme
FRZ59_13890	COG3174	membrane
FRZ59_13900	COG1331	Highly conserved protein containing a thioredoxin domain
FRZ59_13905	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_13910	COG0626	cystathionine gamma-synthase activity
FRZ59_13915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FRZ59_13920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRZ59_13925	COG1619	proteins homologs of microcin C7 resistance protein MccF
FRZ59_13955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRZ59_13960	COG3275	phosphorelay sensor kinase activity
FRZ59_13970	COG1234	tRNA 3'-trailer cleavage
FRZ59_13980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRZ59_13985	COG1702	phosphate starvation-inducible protein PhoH
FRZ59_13990	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
FRZ59_14010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FRZ59_14035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FRZ59_14050	COG1289	transmembrane transporter activity
FRZ59_14090	COG1215	transferase activity, transferring glycosyl groups
FRZ59_14100	COG2244	polysaccharide biosynthetic process
FRZ59_14125	COG0438	transferase activity, transferring glycosyl groups
FRZ59_14195	COG0673	inositol 2-dehydrogenase activity
FRZ59_14205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRZ59_14210	COG1127	ABC transporter
FRZ59_14220	COG0788	formyltetrahydrofolate deformylase activity
FRZ59_14250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRZ59_14255	COG1446	asparaginase
FRZ59_14275	COG1228	amidohydrolase
FRZ59_14280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FRZ59_14285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FRZ59_14290	COG2989	Protein conserved in bacteria
FRZ59_14300	COG2264	protein methyltransferase activity
FRZ59_14305	COG0531	amino acid
FRZ59_14315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRZ59_14330	COG0750	zinc metalloprotease
FRZ59_14335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FRZ59_14350	COG0463	Glycosyl transferase, family 2
FRZ59_14365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FRZ59_14380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRZ59_14400	COG0010	Belongs to the arginase family
FRZ59_14405	COG0012	GTP binding
FRZ59_14410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FRZ59_14415	COG0594	ribonuclease P activity
FRZ59_14425	COG0793	Belongs to the peptidase S41A family
FRZ59_14430	COG0730	response to heat
FRZ59_14435	COG1214	PFAM Peptidase M22, glycoprotease
FRZ59_14445	COG2363	Small membrane protein
FRZ59_14450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FRZ59_14455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRZ59_14465	COG0513	Belongs to the DEAD box helicase family
FRZ59_14470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FRZ59_14495	COG5265	(ABC) transporter
FRZ59_14510	COG4941	Belongs to the sigma-70 factor family
FRZ59_14565	COG1629	transport
FRZ59_14565	COG4206	TonB-dependent receptor
FRZ59_14570	COG0561	phosphatase activity
FRZ59_14575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FRZ59_14575	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRZ59_14595	COG0346	lactoylglutathione lyase activity
FRZ59_14600	COG2353	YceI-like domain
FRZ59_14630	COG1595	DNA-templated transcription, initiation
FRZ59_14650	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FRZ59_14680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRZ59_14695	COG0626	cystathionine gamma-synthase activity
FRZ59_14705	COG0442	prolyl-tRNA aminoacylation
FRZ59_14720	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FRZ59_14725	COG3239	Fatty acid desaturase
FRZ59_14735	COG1030	water channel activity
FRZ59_14745	COG3942	CHAP domain
FRZ59_14745	COG1388	LysM domain
FRZ59_14750	COG0572	uridine kinase
FRZ59_14765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FRZ59_14785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRZ59_14790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRZ59_14795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRZ59_14865	COG0673	inositol 2-dehydrogenase activity
FRZ59_14870	COG0247	lactate metabolic process
FRZ59_14875	COG2270	Major facilitator Superfamily
FRZ59_14900	COG1132	(ABC) transporter
FRZ59_14920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRZ59_14925	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FRZ59_14930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRZ59_14940	COG1185	polyribonucleotide nucleotidyltransferase activity
FRZ59_14945	COG0450	alkyl hydroperoxide reductase
FRZ59_14955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRZ59_14965	COG1181	Belongs to the D-alanine--D-alanine ligase family
FRZ59_14985	COG1295	ribonuclease BN
FRZ59_14995	COG0644	oxidoreductase
FRZ59_15035	COG0640	Transcriptional regulator
FRZ59_15055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRZ59_15085	COG1304	FMN binding
FRZ59_15120	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_15125	COG1733	regulation of RNA biosynthetic process
FRZ59_15150	COG1879	ABC-type sugar transport system periplasmic component
FRZ59_15155	COG1172	Belongs to the binding-protein-dependent transport system permease family
FRZ59_15160	COG1129	ABC transporter
FRZ59_15170	COG3546	catalase activity
FRZ59_15185	COG2133	pyrroloquinoline quinone binding
FRZ59_15205	COG3291	Pkd domain containing protein
FRZ59_15225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRZ59_15230	COG3059	membrane
FRZ59_15255	COG2197	response regulator
FRZ59_15275	COG3119	arylsulfatase activity
FRZ59_15340	COG0346	lactoylglutathione lyase activity
FRZ59_15345	COG0681	Belongs to the peptidase S26 family
FRZ59_15370	COG2207	Transcriptional regulator
FRZ59_15370	COG3708	Transcriptional regulator
FRZ59_15375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRZ59_15385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRZ59_15390	COG1725	Transcriptional regulator
FRZ59_15445	COG2801	Transposase and inactivated derivatives
FRZ59_15535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRZ59_15565	COG2003	Belongs to the UPF0758 family
FRZ59_15600	COG2801	Transposase and inactivated derivatives
FRZ59_15700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FRZ59_15705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRZ59_15710	COG1678	Uncharacterized ACR, COG1678
FRZ59_15725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRZ59_15750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FRZ59_15755	COG0483	inositol monophosphate 1-phosphatase activity
FRZ59_15760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRZ59_15785	COG0573	inorganic phosphate transmembrane transporter activity
FRZ59_15795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRZ59_15805	COG0328	RNA-DNA hybrid ribonuclease activity
FRZ59_15810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRZ59_15815	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FRZ59_15825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FRZ59_15830	COG3263	regulation of cellular component size
FRZ59_15840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRZ59_15845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRZ59_15865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FRZ59_15870	COG0564	pseudouridine synthase activity
FRZ59_15890	COG0693	protein deglycase activity
FRZ59_15900	COG0017	Asparaginyl-tRNA synthetase
FRZ59_15905	COG1970	mechanosensitive ion channel activity
FRZ59_15915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRZ59_15920	COG0791	NLP P60 protein
FRZ59_15935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRZ59_15940	COG0649	NAD binding
FRZ59_15945	COG1595	DNA-templated transcription, initiation
FRZ59_15960	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRZ59_15965	COG1546	Belongs to the CinA family
FRZ59_15965	COG1058	Belongs to the CinA family
FRZ59_15990	COG1253	flavin adenine dinucleotide binding
FRZ59_16000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRZ59_16005	COG0724	RNA recognition motif
FRZ59_16015	COG1297	OPT oligopeptide transporter protein
FRZ59_16020	COG1070	Carbohydrate kinase
FRZ59_16025	COG3537	Alpha-1,2-mannosidase
FRZ59_16050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FRZ59_16055	COG0460	homoserine dehydrogenase
FRZ59_16065	COG0284	orotidine-5'-phosphate decarboxylase activity
FRZ59_16070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FRZ59_16085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FRZ59_16090	COG0616	signal peptide processing
FRZ59_16110	COG0189	ligase activity
FRZ59_16120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FRZ59_16120	COG1796	DNA polymerase
FRZ59_16125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FRZ59_16130	COG0859	PFAM glycosyl transferase family 9
FRZ59_16145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FRZ59_16165	COG0596	Alpha beta hydrolase
FRZ59_16175	COG0110	maltose O-acetyltransferase activity
FRZ59_16185	COG0513	Belongs to the DEAD box helicase family
FRZ59_16195	COG0697	spore germination
FRZ59_16205	COG0488	(ABC) transporter
FRZ59_16210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRZ59_16215	COG2318	DinB family
FRZ59_16230	COG0587	DNA-directed DNA polymerase activity
FRZ59_16250	COG1846	Transcriptional regulator
FRZ59_16255	COG0708	Exodeoxyribonuclease III
FRZ59_16265	COG0673	inositol 2-dehydrogenase activity
FRZ59_16295	COG0667	Aldo Keto reductase
FRZ59_16300	COG2104	thiamine diphosphate biosynthetic process
FRZ59_16305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FRZ59_16315	COG0351	phosphomethylpyrimidine kinase
FRZ59_16320	COG0352	thiamine-phosphate diphosphorylase activity
FRZ59_16325	COG2022	thiamine diphosphate biosynthetic process
FRZ59_16330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRZ59_16335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FRZ59_16340	COG1349	DNA-binding transcription factor activity
FRZ59_16345	COG3511	phospholipase C
FRZ59_16355	COG2814	Major facilitator Superfamily
FRZ59_16360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRZ59_16370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRZ59_16380	COG0584	glycerophosphoryl diester phosphodiesterase
FRZ59_16395	COG2855	membrane
FRZ59_16405	COG2076	Multidrug Resistance protein
FRZ59_16410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FRZ59_16430	COG2816	NAD+ diphosphatase activity
FRZ59_16435	COG3344	reverse transcriptase
FRZ59_16445	COG1629	transport
FRZ59_16445	COG4206	TonB-dependent receptor
FRZ59_16455	COG2197	response regulator
FRZ59_16460	COG2814	Major facilitator Superfamily
FRZ59_16465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRZ59_16470	COG0563	adenylate kinase activity
FRZ59_16475	COG1904	glucuronate isomerase
FRZ59_16480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FRZ59_16490	COG0561	phosphatase activity
FRZ59_16500	COG1629	transport
FRZ59_16500	COG4206	TonB-dependent receptor
FRZ59_16530	COG1131	(ABC) transporter
FRZ59_16540	COG0387	Pfam Sodium calcium exchanger
FRZ59_16570	COG1629	transport
FRZ59_16570	COG4206	TonB-dependent receptor
FRZ59_16590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRZ59_16680	COG2814	Major facilitator Superfamily
FRZ59_16690	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FRZ59_16710	COG0640	Transcriptional regulator
FRZ59_16770	COG1476	TRANSCRIPTIONal
FRZ59_16805	COG3344	reverse transcriptase
FRZ59_16815	COG4864	UPF0365 protein
FRZ59_16820	COG1091	dTDP-4-dehydrorhamnose reductase activity
FRZ59_16830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRZ59_16875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRZ59_16880	COG0745	RESPONSE REGULATOR receiver
FRZ59_16885	COG5002	protein histidine kinase activity
FRZ59_16890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FRZ59_16895	COG0113	porphobilinogen synthase activity
FRZ59_16900	COG0181	hydroxymethylbilane synthase activity
FRZ59_16905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FRZ59_16910	COG0450	alkyl hydroperoxide reductase
FRZ59_16920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRZ59_16950	COG1872	DUF167
FRZ59_17075	COG4585	Histidine kinase
FRZ59_17090	COG0300	oxidoreductase activity
FRZ59_17095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRZ59_17105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FRZ59_17105	COG0116	Belongs to the methyltransferase superfamily
FRZ59_17120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FRZ59_17120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FRZ59_17140	COG0175	sulfate reduction
FRZ59_17155	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRZ59_17180	COG4651	solute:proton antiporter activity
FRZ59_17180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRZ59_17185	COG2353	YceI-like domain
FRZ59_17200	COG0326	Molecular chaperone. Has ATPase activity
FRZ59_17230	COG2323	membrane
FRZ59_17235	COG0723	plastoquinol--plastocyanin reductase activity
FRZ59_17235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRZ59_17260	COG0366	Alpha amylase catalytic
FRZ59_17265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRZ59_17280	COG2197	response regulator
FRZ59_17285	COG3119	arylsulfatase activity
FRZ59_17345	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FRZ59_17345	COG0493	'glutamate synthase
FRZ59_17370	COG2181	nitrate reductase activity
FRZ59_17370	COG0247	lactate metabolic process
FRZ59_17375	COG2181	nitrate reductase activity
FRZ59_17375	COG0247	lactate metabolic process
FRZ59_17385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRZ59_17390	COG0359	binds to the 23S rRNA
FRZ59_17395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FRZ59_17400	COG0360	Binds together with S18 to 16S ribosomal RNA
FRZ59_17410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRZ59_17415	COG0538	isocitrate dehydrogenase activity
FRZ59_17435	COG0069	glutamate synthase activity
FRZ59_17445	COG0148	phosphopyruvate hydratase activity
FRZ59_17450	COG0505	Belongs to the CarA family
FRZ59_17455	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FRZ59_17460	COG0564	pseudouridine synthase activity
FRZ59_17475	COG0577	efflux transmembrane transporter activity
FRZ59_17475	COG1136	(ABC) transporter
FRZ59_17485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRZ59_17505	COG1028	Short-chain dehydrogenase reductase Sdr
FRZ59_17510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FRZ59_17535	COG4152	abc transporter atp-binding protein
FRZ59_17540	COG1668	transmembrane transport
FRZ59_17580	COG2197	response regulator
FRZ59_17585	COG4191	Histidine kinase
FRZ59_17595	COG1477	protein flavinylation
FRZ59_17610	COG1132	(ABC) transporter
FRZ59_17615	COG0101	tRNA pseudouridine synthase activity
FRZ59_17645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FRZ59_17655	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FRZ59_17670	COG0681	Belongs to the peptidase S26 family
FRZ59_17675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRZ59_17685	COG1475	DNA binding
FRZ59_17690	COG1192	Involved in chromosome partitioning
FRZ59_17695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FRZ59_17705	COG1012	belongs to the aldehyde dehydrogenase family
FRZ59_17730	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRZ59_17745	COG2801	Transposase and inactivated derivatives
FRZ59_17845	COG4206	TonB-dependent receptor
FRZ59_17845	COG1629	transport
FRZ59_17895	COG0497	DNA recombination
FRZ59_17905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FRZ59_17910	COG0542	response to heat
FRZ59_17920	COG0488	(ABC) transporter
FRZ59_17940	COG2226	methyltransferase
FRZ59_17950	COG1242	4 iron, 4 sulfur cluster binding
FRZ59_17955	COG1703	isobutyryl-CoA mutase activity
FRZ59_17955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRZ59_17955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRZ59_17960	COG1373	ATPase (AAA superfamily
FRZ59_17970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRZ59_17975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FRZ59_17980	COG0443	Heat shock 70 kDa protein
FRZ59_17985	COG0203	ribosomal protein L17
FRZ59_17990	COG0202	RNA polymerase activity
FRZ59_17995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FRZ59_18000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRZ59_18005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRZ59_18010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FRZ59_18015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FRZ59_18030	COG0200	Binds to the 23S rRNA
FRZ59_18035	COG1841	ribosomal large subunit assembly
FRZ59_18040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRZ59_18045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRZ59_18050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRZ59_18055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FRZ59_18060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRZ59_18065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FRZ59_18070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRZ59_18075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FRZ59_18080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FRZ59_18085	COG0255	Belongs to the universal ribosomal protein uL29 family
FRZ59_18090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FRZ59_18095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRZ59_18100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FRZ59_18105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FRZ59_18110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRZ59_18115	COG0089	rRNA binding
FRZ59_18120	COG0088	Forms part of the polypeptide exit tunnel
FRZ59_18125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRZ59_18130	COG0051	transcription antitermination factor activity, RNA binding
FRZ59_18135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FRZ59_18140	COG0049	tRNA binding
FRZ59_18145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRZ59_18155	COG0156	8-amino-7-oxononanoate synthase activity
FRZ59_18170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRZ59_18185	COG0316	Belongs to the HesB IscA family
FRZ59_18190	COG0673	inositol 2-dehydrogenase activity
FRZ59_18195	COG0577	efflux transmembrane transporter activity
FRZ59_18195	COG1136	(ABC) transporter
FRZ59_18200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRZ59_18205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRZ59_18220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRZ59_18235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRZ59_18240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRZ59_18240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRZ59_18250	COG0252	asparaginase activity
FRZ59_18255	COG0084	hydrolase, TatD family'
FRZ59_18260	COG0545	Peptidyl-prolyl cis-trans isomerase
FRZ59_18265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FRZ59_18270	COG0105	UTP biosynthetic process
FRZ59_18280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRZ59_18290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FRZ59_18295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRZ59_18310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FRZ59_18330	COG1086	Polysaccharide biosynthesis protein
FRZ59_18375	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type