locus-tag	class	description
HEQ12_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HEQ12_00015	COG0515	serine threonine protein kinase
HEQ12_00015	COG3064	Membrane
HEQ12_00015	COG4991	sh3 domain protein
HEQ12_00025	COG1187	pseudouridine synthase activity
HEQ12_00035	COG0443	Heat shock 70 kDa protein
HEQ12_00040	COG0123	including yeast histone deacetylase and acetoin utilization protein
HEQ12_00060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEQ12_00065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HEQ12_00070	COG0515	serine threonine protein kinase
HEQ12_00070	COG3266	domain, Protein
HEQ12_00100	COG1070	Carbohydrate kinase
HEQ12_00125	COG0625	glutathione transferase activity
HEQ12_00130	COG0482	sulfurtransferase activity
HEQ12_00140	COG0424	maF-like protein
HEQ12_00200	COG1122	ATPase activity
HEQ12_00205	COG0357	Ribosomal RNA small subunit methyltransferase G
HEQ12_00210	COG0196	riboflavin kinase activity
HEQ12_00225	COG0714	Associated with various cellular activities
HEQ12_00230	COG0275	rRNA processing
HEQ12_00235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEQ12_00245	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HEQ12_00255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEQ12_00280	COG1136	(ABC) transporter
HEQ12_00285	COG2131	deaminase
HEQ12_00305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HEQ12_00315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEQ12_00320	COG0415	Belongs to the DNA photolyase family
HEQ12_00325	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEQ12_00365	COG0140	phosphoribosyl-ATP diphosphatase activity
HEQ12_00365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEQ12_00370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEQ12_00375	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_00375	COG0515	serine threonine protein kinase
HEQ12_00390	COG0023	Translation Initiation Factor
HEQ12_00395	COG0401	homolog of Blt101
HEQ12_00415	COG0683	leucine binding
HEQ12_00450	COG0303	'Molybdopterin
HEQ12_00470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ12_00480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEQ12_00485	COG0513	Belongs to the DEAD box helicase family
HEQ12_00495	COG0592	DNA-directed DNA polymerase activity
HEQ12_00500	COG2010	Cytochrome c
HEQ12_00515	COG0166	Belongs to the GPI family
HEQ12_00555	COG0678	peroxiredoxin activity
HEQ12_00560	COG0735	belongs to the Fur family
HEQ12_00570	COG0113	porphobilinogen synthase activity
HEQ12_00580	COG1361	Conserved repeat domain
HEQ12_00585	COG0546	phosphoglycolate phosphatase activity
HEQ12_00640	COG1834	amidinotransferase
HEQ12_00660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEQ12_00675	COG2133	pyrroloquinoline quinone binding
HEQ12_00675	COG5183	chlorophyll binding
HEQ12_00680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEQ12_00690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ12_00700	COG1051	belongs to the nudix hydrolase family
HEQ12_00705	COG0628	permease
HEQ12_00715	COG0587	DNA-directed DNA polymerase activity
HEQ12_00740	COG1088	dTDP-glucose 4,6-dehydratase activity
HEQ12_00745	COG0701	Predicted permease
HEQ12_00780	COG1053	succinate dehydrogenase
HEQ12_00795	COG2211	Major facilitator Superfamily
HEQ12_00800	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HEQ12_00805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEQ12_00825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEQ12_00830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEQ12_00850	COG0134	indole-3-glycerol-phosphate synthase activity
HEQ12_00855	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEQ12_00865	COG0442	prolyl-tRNA aminoacylation
HEQ12_00895	COG0511	ligase activity, forming carbon-carbon bonds
HEQ12_00900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEQ12_00905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEQ12_00930	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ12_00945	COG1429	ligase activity, forming nitrogen-metal bonds
HEQ12_01070	COG3385	transposase activity
HEQ12_01090	COG1487	ribonuclease activity
HEQ12_01095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEQ12_01095	COG2022	thiamine diphosphate biosynthetic process
HEQ12_01110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEQ12_01115	COG1063	alcohol dehydrogenase
HEQ12_01120	COG0483	inositol monophosphate 1-phosphatase activity
HEQ12_01140	COG1215	transferase activity, transferring glycosyl groups
HEQ12_01145	COG0463	Glycosyl transferase, family 2
HEQ12_01150	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEQ12_01155	COG0697	spore germination
HEQ12_01160	COG0314	molybdopterin synthase activity
HEQ12_01165	COG0083	homoserine kinase activity
HEQ12_01180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEQ12_01185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEQ12_01190	COG0512	Glutamine amidotransferase of anthranilate synthase
HEQ12_01190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEQ12_01230	COG0489	protein tyrosine kinase activity
HEQ12_01245	COG2124	cytochrome p450
HEQ12_01280	COG3093	addiction module antidote protein HigA
HEQ12_01290	COG3609	addiction module antidote protein, CC2985 family
HEQ12_01370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEQ12_01380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEQ12_01385	COG0484	heat shock protein binding
HEQ12_01395	COG1162	GTPase activity
HEQ12_01400	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEQ12_01415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEQ12_01420	COG1543	Belongs to the glycosyl hydrolase 57 family
HEQ12_01430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEQ12_01440	COG1040	competence protein
HEQ12_01465	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEQ12_01485	COG1666	GTP binding
HEQ12_01495	COG0315	cyclic pyranopterin monophosphate synthase activity
HEQ12_01505	COG0788	formyltetrahydrofolate deformylase activity
HEQ12_01530	COG1131	(ABC) transporter
HEQ12_01550	COG0004	ammonium transporteR
HEQ12_01560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEQ12_01570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEQ12_01620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEQ12_01630	COG0328	RNA-DNA hybrid ribonuclease activity
HEQ12_01650	COG1012	belongs to the aldehyde dehydrogenase family
HEQ12_01670	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_01670	COG0515	serine threonine protein kinase
HEQ12_01720	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ12_01730	COG0191	fructose-bisphosphate aldolase activity
HEQ12_01735	COG0629	single-stranded DNA binding
HEQ12_01740	COG2255	four-way junction helicase activity
HEQ12_01750	COG4636	protein conserved in cyanobacteria
HEQ12_01775	COG0126	phosphoglycerate kinase activity
HEQ12_01780	COG0589	response to stress
HEQ12_01805	COG0542	response to heat
HEQ12_01820	COG1127	ABC transporter
HEQ12_01825	COG0515	serine threonine protein kinase
HEQ12_01830	COG3064	Membrane
HEQ12_01830	COG4991	sh3 domain protein
HEQ12_01830	COG0515	serine threonine protein kinase
HEQ12_01840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEQ12_01850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ12_01860	COG0018	arginyl-trna synthetase
HEQ12_01870	COG2211	Major facilitator Superfamily
HEQ12_01880	COG0159	tryptophan synthase activity
HEQ12_01900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HEQ12_01905	COG0170	dolichyl monophosphate biosynthetic process
HEQ12_01945	COG0528	UMP kinase activity
HEQ12_01950	COG0233	cytoplasmic translational termination
HEQ12_01955	COG0492	ferredoxin-NADP+ reductase activity
HEQ12_01975	COG0628	permease
HEQ12_01985	COG0516	GMP reductase activity
HEQ12_01990	COG3118	belongs to the thioredoxin family
HEQ12_02015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEQ12_02025	COG0589	response to stress
HEQ12_02045	COG0343	queuine tRNA-ribosyltransferase activity
HEQ12_02055	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HEQ12_02100	COG0109	protoheme IX farnesyltransferase activity
HEQ12_02110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEQ12_02115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEQ12_02120	COG1845	cytochrome c oxidase, subunit III
HEQ12_02130	COG0586	Pfam SNARE associated Golgi protein
HEQ12_02135	COG1366	Belongs to the anti-sigma-factor antagonist family
HEQ12_02165	COG1012	belongs to the aldehyde dehydrogenase family
HEQ12_02170	COG2059	Chromate
HEQ12_02175	COG0584	glycerophosphoryl diester phosphodiesterase
HEQ12_02180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEQ12_02185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEQ12_02195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEQ12_02210	COG0248	Ppx GppA phosphatase
HEQ12_02235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEQ12_02260	COG1063	alcohol dehydrogenase
HEQ12_02270	COG0708	Exodeoxyribonuclease III
HEQ12_02295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEQ12_02320	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HEQ12_02345	COG2197	response regulator
HEQ12_02350	COG0438	transferase activity, transferring glycosyl groups
HEQ12_02360	COG0416	fatty acid biosynthetic process
HEQ12_02365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEQ12_02370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEQ12_02395	COG1842	Phage shock protein A
HEQ12_02400	COG1842	Phage shock protein A
HEQ12_02405	COG3118	belongs to the thioredoxin family
HEQ12_02410	COG0436	Aminotransferase
HEQ12_02420	COG0484	heat shock protein binding
HEQ12_02430	COG0723	plastoquinol--plastocyanin reductase activity
HEQ12_02435	COG3258	Cytochrome c
HEQ12_02440	COG0363	glucosamine-6-phosphate deaminase activity
HEQ12_02445	COG1136	(ABC) transporter
HEQ12_02445	COG0577	efflux transmembrane transporter activity
HEQ12_02465	COG3321	synthase
HEQ12_02465	COG0604	alcohol dehydrogenase
HEQ12_02475	COG2070	2-Nitropropane dioxygenase
HEQ12_02475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEQ12_02485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEQ12_02485	COG3320	Male sterility
HEQ12_02500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HEQ12_02505	COG1799	cell septum assembly
HEQ12_02510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEQ12_02535	COG0720	synthase
HEQ12_02540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEQ12_02545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEQ12_02550	COG1606	tRNA processing
HEQ12_02565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEQ12_02570	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HEQ12_02570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEQ12_02580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEQ12_02600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ12_02605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ12_02645	COG3854	ATPases associated with a variety of cellular activities
HEQ12_02650	COG0217	transcriptional regulatory protein
HEQ12_02655	COG0322	excinuclease ABC activity
HEQ12_02660	COG0457	Tetratricopeptide repeat
HEQ12_02660	COG0463	Glycosyl transferase, family 2
HEQ12_02665	COG0436	Aminotransferase
HEQ12_02675	COG0406	alpha-ribazole phosphatase activity
HEQ12_02685	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HEQ12_02700	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HEQ12_02735	COG0848	biopolymer transport protein
HEQ12_02740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEQ12_02760	COG2046	Belongs to the sulfate adenylyltransferase family
HEQ12_02770	COG1032	radical SAM domain protein
HEQ12_02790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEQ12_02795	COG0577	efflux transmembrane transporter activity
HEQ12_02795	COG1136	(ABC) transporter
HEQ12_02800	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ12_02830	COG0157	Belongs to the NadC ModD family
HEQ12_02835	COG0488	(ABC) transporter
HEQ12_02855	COG0215	cysteine-tRNA ligase activity
HEQ12_02865	COG0523	cobalamin synthesis protein
HEQ12_02870	COG0612	Peptidase, M16
HEQ12_02875	COG3001	Fructosamine kinase
HEQ12_02885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEQ12_02890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEQ12_02900	COG0085	RNA polymerase activity
HEQ12_02905	COG0084	hydrolase, TatD family'
HEQ12_02910	COG0268	Binds directly to 16S ribosomal RNA
HEQ12_02915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEQ12_02935	COG2119	membrane
HEQ12_02940	COG2226	methyltransferase
HEQ12_02955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEQ12_02955	COG0515	serine threonine protein kinase
HEQ12_02980	COG0649	NAD binding
HEQ12_03010	COG2205	protein histidine kinase activity
HEQ12_03015	COG1027	Aspartate ammonia-lyase
HEQ12_03025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEQ12_03035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEQ12_03035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEQ12_03060	COG0574	Belongs to the PEP-utilizing enzyme family
HEQ12_03060	COG3848	Pyruvate phosphate dikinase
HEQ12_03085	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEQ12_03105	COG0149	triose-phosphate isomerase activity
HEQ12_03110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEQ12_03115	COG0330	HflC and HflK could
HEQ12_03120	COG1596	polysaccharide export
HEQ12_03125	COG1131	(ABC) transporter
HEQ12_03130	COG0131	Imidazoleglycerol-phosphate dehydratase
HEQ12_03135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEQ12_03140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEQ12_03145	COG4372	Transposase
HEQ12_03185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ12_03190	COG1372	Participates in initiation and elongation during chromosome replication
HEQ12_03190	COG0187	DNA topoisomerase II activity
HEQ12_03195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEQ12_03205	COG4680	protein conserved in bacteria
HEQ12_03220	COG0706	membrane insertase activity
HEQ12_03230	COG0594	ribonuclease P activity
HEQ12_03235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HEQ12_03260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEQ12_03260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEQ12_03275	COG3385	transposase activity
HEQ12_03290	COG0748	coenzyme F420 binding
HEQ12_03295	COG3385	transposase activity
HEQ12_03315	COG0525	valine-tRNA ligase activity
HEQ12_03325	COG0181	hydroxymethylbilane synthase activity
HEQ12_03330	COG0297	glycogen (starch) synthase activity
HEQ12_03360	COG4948	Mandelate Racemase Muconate Lactonizing
HEQ12_03375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HEQ12_03380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEQ12_03395	COG3903	Transcriptional regulator
HEQ12_03395	COG3629	intracellular signal transduction
HEQ12_03410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEQ12_03415	COG0745	RESPONSE REGULATOR receiver
HEQ12_03455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEQ12_03465	COG3878	Protein conserved in bacteria
HEQ12_03470	COG0517	IMP dehydrogenase activity
HEQ12_03470	COG1994	Peptidase M50
HEQ12_03480	COG0135	phosphoribosylanthranilate isomerase activity
HEQ12_03485	COG0302	gtp cyclohydrolase
HEQ12_03490	COG0300	oxidoreductase activity
HEQ12_03495	COG0825	malonyl-CoA metabolic process
HEQ12_03500	COG5322	oxidoreductase activity
HEQ12_03505	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HEQ12_03510	COG2154	pterin-4-alpha-carbinolamine dehydratase
HEQ12_03520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEQ12_03530	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HEQ12_03560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HEQ12_03570	COG0606	chelatase, subunit chli
HEQ12_03600	COG0556	nucleotide-excision repair
HEQ12_03610	COG0776	regulation of translation
HEQ12_03620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEQ12_03625	COG2197	response regulator
HEQ12_03640	COG0859	PFAM glycosyl transferase family 9
HEQ12_03645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEQ12_03665	COG1372	Participates in initiation and elongation during chromosome replication
HEQ12_03665	COG1372	Participates in initiation and elongation during chromosome replication
HEQ12_03665	COG0305	Participates in initiation and elongation during chromosome replication
HEQ12_03665	COG0305	Participates in initiation and elongation during chromosome replication
HEQ12_03670	COG0359	binds to the 23S rRNA
HEQ12_03675	COG2226	methyltransferase
HEQ12_03680	COG4399	Belongs to the UPF0754 family
HEQ12_03685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEQ12_03685	COG0426	domain, Protein
HEQ12_03690	COG0426	domain, Protein
HEQ12_03690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEQ12_03695	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ12_03715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ12_03740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEQ12_03745	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEQ12_03770	COG2217	Heavy metal translocating P-type atpase
HEQ12_03775	COG1090	epimerase
HEQ12_03780	COG0450	alkyl hydroperoxide reductase
HEQ12_03805	COG1175	transmembrane transport
HEQ12_03810	COG0513	Belongs to the DEAD box helicase family
HEQ12_03815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEQ12_03820	COG0434	BtpA family
HEQ12_03825	COG4243	Vitamin k epoxide reductase
HEQ12_03830	COG1595	DNA-templated transcription, initiation
HEQ12_03855	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEQ12_03865	COG1555	photosystem II stabilization
HEQ12_03875	COG1968	undecaprenyl-diphosphatase activity
HEQ12_03900	COG0456	acetyltransferase
HEQ12_03915	COG2223	nitrite transmembrane transporter activity
HEQ12_03930	COG0419	ATPase involved in DNA repair
HEQ12_03955	COG4636	protein conserved in cyanobacteria
HEQ12_03980	COG0784	Response regulator, receiver
HEQ12_03980	COG2205	protein histidine kinase activity
HEQ12_03980	COG5002	protein histidine kinase activity
HEQ12_04000	COG0154	amidase activity
HEQ12_04035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEQ12_04055	COG0408	coproporphyrinogen oxidase activity
HEQ12_04065	COG0489	protein tyrosine kinase activity
HEQ12_04070	COG0772	Belongs to the SEDS family
HEQ12_04085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEQ12_04095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEQ12_04100	COG2226	methyltransferase
HEQ12_04105	COG1252	NADH dehydrogenase
HEQ12_04120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEQ12_04125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEQ12_04130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEQ12_04135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEQ12_04140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEQ12_04145	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEQ12_04150	COG0356	it plays a direct role in the translocation of protons across the membrane
HEQ12_04165	COG1429	ligase activity, forming nitrogen-metal bonds
HEQ12_04195	COG0339	signal peptide processing
HEQ12_04205	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEQ12_04215	COG0574	Belongs to the PEP-utilizing enzyme family
HEQ12_04215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEQ12_04220	COG1285	pathogenesis
HEQ12_04240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ12_04250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEQ12_04265	COG2304	oxidoreductase activity
HEQ12_04270	COG2304	oxidoreductase activity
HEQ12_04305	COG2909	trisaccharide binding
HEQ12_04310	COG1408	metallophosphoesterase
HEQ12_04315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEQ12_04335	COG3659	wide pore channel activity
HEQ12_04340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEQ12_04345	COG5398	heme oxygenase
HEQ12_04350	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HEQ12_04355	COG0803	Belongs to the bacterial solute-binding protein 9 family
HEQ12_04360	COG1121	(ABC) transporter
HEQ12_04365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEQ12_04375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEQ12_04380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEQ12_04400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEQ12_04410	COG5002	protein histidine kinase activity
HEQ12_04415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEQ12_04420	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HEQ12_04430	COG3659	wide pore channel activity
HEQ12_04440	COG0517	IMP dehydrogenase activity
HEQ12_04440	COG1125	glycine betaine transport
HEQ12_04455	COG0523	cobalamin synthesis protein
HEQ12_04480	COG4680	protein conserved in bacteria
HEQ12_04495	COG1126	abc transporter atp-binding protein
HEQ12_04500	COG0765	amino acid transport
HEQ12_04505	COG4597	amino acid ABC transporter
HEQ12_04510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEQ12_04520	COG0681	Belongs to the peptidase S26 family
HEQ12_04525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEQ12_04530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEQ12_04535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ12_04545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEQ12_04560	COG1253	flavin adenine dinucleotide binding
HEQ12_04565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEQ12_04570	COG0673	inositol 2-dehydrogenase activity
HEQ12_04590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEQ12_04600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEQ12_04610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HEQ12_04660	COG0497	DNA recombination
HEQ12_04665	COG1473	amidohydrolase
HEQ12_04670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEQ12_04675	COG3266	domain, Protein
HEQ12_04675	COG0515	serine threonine protein kinase
HEQ12_04680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEQ12_04700	COG1217	gtp-binding protein TYPA
HEQ12_04705	COG0038	chloride channel
HEQ12_04720	COG2815	serine threonine protein kinase
HEQ12_04720	COG0515	serine threonine protein kinase
HEQ12_04730	COG0312	modulator of DNA gyrase
HEQ12_04740	COG1573	uracil-dna glycosylase
HEQ12_04770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HEQ12_04775	COG0740	serine-type endopeptidase activity
HEQ12_04780	COG0740	serine-type endopeptidase activity
HEQ12_04785	COG0484	heat shock protein binding
HEQ12_04835	COG0175	sulfate reduction
HEQ12_04845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEQ12_04875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ12_04910	COG2166	iron-sulfur cluster assembly
HEQ12_04925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEQ12_04930	COG0778	Nitroreductase
HEQ12_04935	COG3118	belongs to the thioredoxin family
HEQ12_04950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEQ12_04970	COG0792	nuclease activity
HEQ12_04980	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEQ12_04990	COG0569	domain protein
HEQ12_04995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HEQ12_05000	COG2226	methyltransferase
HEQ12_05005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEQ12_05015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEQ12_05035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEQ12_05040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEQ12_05045	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEQ12_05050	COG0546	phosphoglycolate phosphatase activity
HEQ12_05055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEQ12_05070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_05075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEQ12_05080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEQ12_05095	COG0697	spore germination
HEQ12_05100	COG0306	phosphate transporter
HEQ12_05115	COG2084	Dehydrogenase
HEQ12_05145	COG1994	Peptidase M50
HEQ12_05145	COG0517	IMP dehydrogenase activity
HEQ12_05160	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ12_05175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEQ12_05180	COG3536	Protein conserved in bacteria
HEQ12_05190	COG0138	bifunctional purine biosynthesis protein purh
HEQ12_05205	COG0095	Lipoate-protein ligase
HEQ12_05225	COG1196	nuclear chromosome segregation
HEQ12_05225	COG1674	ftsk spoiiie
HEQ12_05230	COG1192	Involved in chromosome partitioning
HEQ12_05235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEQ12_05240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEQ12_05240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HEQ12_05275	COG1487	ribonuclease activity
HEQ12_05285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEQ12_05290	COG0367	asparagine synthase
HEQ12_05305	COG0237	dephospho-CoA kinase activity
HEQ12_05305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEQ12_05330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HEQ12_05350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEQ12_05355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEQ12_05360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEQ12_05365	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEQ12_05370	COG0740	serine-type endopeptidase activity
HEQ12_05375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEQ12_05385	COG0180	Tryptophanyl-tRNA synthetase
HEQ12_05405	COG0515	serine threonine protein kinase
HEQ12_05405	COG2815	serine threonine protein kinase
HEQ12_05430	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ12_05435	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ12_05445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEQ12_05455	COG0702	epimerase
HEQ12_05460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEQ12_05465	COG0512	Glutamine amidotransferase of anthranilate synthase
HEQ12_05465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEQ12_05470	COG0745	RESPONSE REGULATOR receiver
HEQ12_05500	COG0134	indole-3-glycerol-phosphate synthase activity
HEQ12_05505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEQ12_05520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEQ12_05535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEQ12_05535	COG0758	DNA mediated transformation
HEQ12_05550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_05555	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HEQ12_05585	COG2197	response regulator
HEQ12_05595	COG1234	tRNA 3'-trailer cleavage
HEQ12_05600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEQ12_05610	COG1104	cysteine desulfurase activity
HEQ12_05615	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_05615	COG0515	serine threonine protein kinase
HEQ12_05620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEQ12_05650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEQ12_05655	COG0745	RESPONSE REGULATOR receiver
HEQ12_05675	COG0310	cobalt ion transport
HEQ12_05680	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HEQ12_05690	COG1122	ATPase activity
HEQ12_05705	COG1120	ATPase activity
HEQ12_05710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEQ12_05735	COG3385	transposase activity
HEQ12_05745	COG1294	oxidase, subunit
HEQ12_05765	COG2319	Wd-40 repeat
HEQ12_05805	COG0842	Transport permease protein
HEQ12_05805	COG1131	(ABC) transporter
HEQ12_05805	COG1716	ATPase activity
HEQ12_05810	COG3266	domain, Protein
HEQ12_05810	COG0515	serine threonine protein kinase
HEQ12_05820	COG0501	Belongs to the peptidase M48B family
HEQ12_05840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEQ12_05845	COG0824	Thioesterase
HEQ12_05850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_05855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_05860	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_05865	COG1773	rubredoxin
HEQ12_05870	COG4447	cellulose binding
HEQ12_05935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEQ12_05940	COG0189	ligase activity
HEQ12_05945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HEQ12_05950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEQ12_05950	COG0519	Catalyzes the synthesis of GMP from XMP
HEQ12_05955	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HEQ12_05975	COG1496	oxidoreductase activity
HEQ12_05985	COG4942	peptidase
HEQ12_05990	COG0307	riboflavin synthase, alpha
HEQ12_06020	COG1480	7TM receptor with intracellular HD hydrolase
HEQ12_06030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEQ12_06035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEQ12_06035	COG1754	DNA topoisomerase type I activity
HEQ12_06040	COG1748	Saccharopine dehydrogenase
HEQ12_06065	COG0583	DNA-binding transcription factor activity
HEQ12_06070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEQ12_06075	COG0243	molybdopterin cofactor binding
HEQ12_06080	COG2223	nitrite transmembrane transporter activity
HEQ12_06095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HEQ12_06100	COG0484	heat shock protein binding
HEQ12_06105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEQ12_06110	COG1959	2 iron, 2 sulfur cluster binding
HEQ12_06115	COG3659	wide pore channel activity
HEQ12_06135	COG1122	ATPase activity
HEQ12_06140	COG3688	RNA-binding protein containing a PIN domain
HEQ12_06160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEQ12_06180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEQ12_06195	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ12_06210	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ12_06215	COG0300	oxidoreductase activity
HEQ12_06215	COG0318	PFAM AMP-dependent synthetase and ligase
HEQ12_06215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEQ12_06215	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ12_06215	COG3321	synthase
HEQ12_06230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HEQ12_06240	COG0805	protein transport
HEQ12_06245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEQ12_06270	COG0515	serine threonine protein kinase
HEQ12_06270	COG3266	domain, Protein
HEQ12_06285	COG0540	Belongs to the ATCase OTCase family
HEQ12_06290	COG2239	Acts as a magnesium transporter
HEQ12_06305	COG1316	TRANSCRIPTIONal
HEQ12_06310	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_06315	COG0728	peptidoglycan biosynthetic process
HEQ12_06325	COG3385	transposase activity
HEQ12_06365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEQ12_06380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEQ12_06405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEQ12_06410	COG0148	phosphopyruvate hydratase activity
HEQ12_06430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEQ12_06440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEQ12_06465	COG3385	transposase activity
HEQ12_06570	COG0308	aminopeptidase N
HEQ12_06585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEQ12_06600	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HEQ12_06605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEQ12_06625	COG1546	Belongs to the CinA family
HEQ12_06625	COG1058	Belongs to the CinA family
HEQ12_06640	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEQ12_06690	COG1216	Glycosyl transferase, family 2
HEQ12_06705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEQ12_06710	COG2226	methyltransferase
HEQ12_06735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEQ12_06805	COG0297	glycogen (starch) synthase activity
HEQ12_06815	COG0438	transferase activity, transferring glycosyl groups
HEQ12_06820	COG0438	transferase activity, transferring glycosyl groups
HEQ12_06830	COG0367	asparagine synthase
HEQ12_06835	COG0438	transferase activity, transferring glycosyl groups
HEQ12_06840	COG1492	cobalamin metabolic process
HEQ12_06850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEQ12_06865	COG0534	Mate efflux family protein
HEQ12_06870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_06880	COG0826	peptidase U32
HEQ12_06905	COG0504	CTP synthase activity
HEQ12_06910	COG1940	carbohydrate kinase activity
HEQ12_06920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEQ12_06925	COG4968	Prepilin-type N-terminal cleavage methylation domain
HEQ12_06930	COG4968	Prepilin-type N-terminal cleavage methylation domain
HEQ12_06935	COG4968	Prepilin-type N-terminal cleavage methylation domain
HEQ12_06955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEQ12_06960	COG1121	(ABC) transporter
HEQ12_06965	COG0803	Belongs to the bacterial solute-binding protein 9 family
HEQ12_06970	COG3659	wide pore channel activity
HEQ12_06980	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HEQ12_06995	COG0438	transferase activity, transferring glycosyl groups
HEQ12_07010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEQ12_07020	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HEQ12_07030	COG2319	Wd-40 repeat
HEQ12_07030	COG5635	Nacht domain
HEQ12_07040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEQ12_07050	COG2066	Belongs to the glutaminase family
HEQ12_07060	COG2885	chlorophyll binding
HEQ12_07075	COG1192	Involved in chromosome partitioning
HEQ12_07085	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_07085	COG0515	serine threonine protein kinase
HEQ12_07090	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ12_07095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEQ12_07100	COG0459	protein refolding
HEQ12_07110	COG0358	DNA primase activity
HEQ12_07140	COG2197	response regulator
HEQ12_07150	COG4585	Histidine kinase
HEQ12_07170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEQ12_07180	COG1116	anion transmembrane transporter activity
HEQ12_07185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ12_07185	COG1116	anion transmembrane transporter activity
HEQ12_07190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEQ12_07210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEQ12_07230	COG3903	Transcriptional regulator
HEQ12_07230	COG2319	Wd-40 repeat
HEQ12_07235	COG0515	serine threonine protein kinase
HEQ12_07240	COG0538	isocitrate dehydrogenase activity
HEQ12_07270	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_07270	COG0515	serine threonine protein kinase
HEQ12_07280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEQ12_07295	COG1530	ribonuclease E activity
HEQ12_07300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEQ12_07310	COG1605	Chorismate mutase
HEQ12_07310	COG0077	Prephenate dehydratase
HEQ12_07475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEQ12_07495	COG0505	Belongs to the CarA family
HEQ12_07505	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HEQ12_07510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEQ12_07520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEQ12_07520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEQ12_07530	COG0129	dihydroxy-acid dehydratase activity
HEQ12_07545	COG2886	Uncharacterised protein family (UPF0175)
HEQ12_07565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEQ12_07570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEQ12_07575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEQ12_07580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEQ12_07585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEQ12_07590	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEQ12_07600	COG0483	inositol monophosphate 1-phosphatase activity
HEQ12_07610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEQ12_07620	COG0557	exoribonuclease II activity
HEQ12_07625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEQ12_07630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEQ12_07650	COG1106	Psort location Cytoplasmic, score
HEQ12_07680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEQ12_07690	COG0113	porphobilinogen synthase activity
HEQ12_07695	COG0523	cobalamin synthesis protein
HEQ12_07700	COG0302	gtp cyclohydrolase
HEQ12_07725	COG1002	Type II restriction enzyme, methylase subunits
HEQ12_07755	COG1489	DNA binding
HEQ12_07765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEQ12_07775	COG0154	amidase activity
HEQ12_07780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEQ12_07785	COG0457	Tetratricopeptide repeat
HEQ12_07790	COG4935	Belongs to the peptidase S8 family
HEQ12_07790	COG1404	Belongs to the peptidase S8 family
HEQ12_07830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEQ12_07870	COG0107	imidazoleglycerol-phosphate synthase activity
HEQ12_07890	COG0745	RESPONSE REGULATOR receiver
HEQ12_07895	COG1366	Belongs to the anti-sigma-factor antagonist family
HEQ12_07905	COG2385	sporulation resulting in formation of a cellular spore
HEQ12_07920	COG0653	protein targeting
HEQ12_07940	COG2010	Cytochrome c
HEQ12_07950	COG0742	ribosomal rna small subunit methyltransferase
HEQ12_07955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEQ12_07975	COG0438	transferase activity, transferring glycosyl groups
HEQ12_07985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEQ12_07990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEQ12_08025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_08035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEQ12_08080	COG0312	modulator of DNA gyrase
HEQ12_08090	COG3118	belongs to the thioredoxin family
HEQ12_08095	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEQ12_08105	COG1022	Amp-dependent synthetase and ligase
HEQ12_08115	COG0514	ATP-dependent DNA helicase (RecQ)
HEQ12_08140	COG0612	Peptidase, M16
HEQ12_08145	COG0612	Peptidase, M16
HEQ12_08160	COG0384	phenazine biosynthesis protein PhzF
HEQ12_08270	COG3385	transposase activity
HEQ12_08320	COG2003	Belongs to the UPF0758 family
HEQ12_08325	COG0572	uridine kinase
HEQ12_08345	COG2442	InterPro IPR007367
HEQ12_08370	COG0247	lactate metabolic process
HEQ12_08375	COG0277	FAD linked oxidase domain protein
HEQ12_08380	COG3659	wide pore channel activity
HEQ12_08385	COG0704	Plays a role in the regulation of phosphate uptake
HEQ12_08390	COG5002	protein histidine kinase activity
HEQ12_08395	COG0745	RESPONSE REGULATOR receiver
HEQ12_08420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEQ12_08420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEQ12_08435	COG0167	dihydroorotate dehydrogenase activity
HEQ12_08440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEQ12_08460	COG3119	arylsulfatase activity
HEQ12_08475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEQ12_08510	COG0529	Catalyzes the synthesis of activated sulfate
HEQ12_08520	COG0277	FAD linked oxidase domain protein
HEQ12_08525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEQ12_08545	COG0539	negative regulation of cytoplasmic translation
HEQ12_08575	COG2828	Protein conserved in bacteria
HEQ12_08595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEQ12_08605	COG0571	ribonuclease III activity
HEQ12_08615	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEQ12_08620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEQ12_08650	COG2885	chlorophyll binding
HEQ12_08650	COG3047	cAMP biosynthetic process
HEQ12_08690	COG3394	polysaccharide catabolic process
HEQ12_08730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEQ12_08760	COG0784	Response regulator, receiver
HEQ12_08765	COG0564	pseudouridine synthase activity
HEQ12_08780	COG0237	dephospho-CoA kinase activity
HEQ12_08785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEQ12_08790	COG1413	lyase activity
HEQ12_08795	COG1413	lyase activity
HEQ12_08800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEQ12_08805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEQ12_08810	COG0237	dephospho-CoA kinase activity
HEQ12_08815	COG0237	dephospho-CoA kinase activity
HEQ12_08840	COG0121	glutamine amidotransferase
HEQ12_08845	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEQ12_08850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEQ12_08855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEQ12_08860	COG4208	sulfate ABC transporter
HEQ12_08875	COG4771	TonB-dependent receptor
HEQ12_08890	COG0456	acetyltransferase
HEQ12_08895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ12_08900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEQ12_08930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEQ12_08955	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HEQ12_08975	COG0395	ABC-type sugar transport system, permease component
HEQ12_08990	COG4999	Histidine kinase
HEQ12_08990	COG3850	Histidine kinase
HEQ12_08990	COG3437	response regulator, receiver
HEQ12_08990	COG2205	protein histidine kinase activity
HEQ12_08995	COG4999	Histidine kinase
HEQ12_08995	COG3850	Histidine kinase
HEQ12_08995	COG2205	protein histidine kinase activity
HEQ12_08995	COG3437	response regulator, receiver
HEQ12_09000	COG0745	RESPONSE REGULATOR receiver
HEQ12_09005	COG0814	amino acid
HEQ12_09020	COG0440	acetolactate synthase activity
HEQ12_09030	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HEQ12_09040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEQ12_09055	COG0793	Belongs to the peptidase S41A family
HEQ12_09060	COG2045	Belongs to the ComB family
HEQ12_09065	COG2363	Small membrane protein
HEQ12_09070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEQ12_09075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEQ12_09080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEQ12_09100	COG1361	Conserved repeat domain
HEQ12_09110	COG0352	thiamine-phosphate diphosphorylase activity
HEQ12_09150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEQ12_09180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEQ12_09185	COG0436	Aminotransferase
HEQ12_09205	COG1177	transmembrane transport
HEQ12_09210	COG0438	transferase activity, transferring glycosyl groups
HEQ12_09215	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HEQ12_09295	COG0003	Pfam Anion-transporting ATPase
HEQ12_09330	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEQ12_09345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEQ12_09380	COG5554	nitrogen fixation
HEQ12_09385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEQ12_09400	COG1045	serine acetyltransferase
HEQ12_09415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEQ12_09420	COG1104	cysteine desulfurase activity
HEQ12_09425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEQ12_09425	COG0822	iron-sulfur transferase activity
HEQ12_09425	COG2906	2 iron, 2 sulfur cluster binding
HEQ12_09430	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HEQ12_09475	COG0582	viral genome integration into host DNA
HEQ12_09485	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ12_09620	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ12_09630	COG0582	viral genome integration into host DNA
HEQ12_09635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ12_09640	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ12_09645	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ12_09650	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ12_09665	COG5420	small protein containing a coiled-coil domain
HEQ12_09675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEQ12_09680	COG0316	Belongs to the HesB IscA family
HEQ12_09685	COG0633	Ferredoxin
HEQ12_09730	COG0443	Heat shock 70 kDa protein
HEQ12_09735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEQ12_09740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEQ12_09750	COG1459	type II secretion system
HEQ12_09765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEQ12_09780	COG0438	transferase activity, transferring glycosyl groups
HEQ12_09785	COG1216	Glycosyl transferase, family 2
HEQ12_09795	COG1132	(ABC) transporter
HEQ12_09810	COG0489	protein tyrosine kinase activity
HEQ12_09815	COG0438	transferase activity, transferring glycosyl groups
HEQ12_09840	COG1216	Glycosyl transferase, family 2
HEQ12_09845	COG1216	Glycosyl transferase, family 2
HEQ12_09850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEQ12_09855	COG0579	oxidoreductase
HEQ12_09860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEQ12_09875	COG4245	von Willebrand factor, type A
HEQ12_09880	COG0784	Response regulator, receiver
HEQ12_09890	COG0668	transmembrane transport
HEQ12_09895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HEQ12_09990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEQ12_09995	COG0398	Pfam SNARE associated Golgi protein
HEQ12_10010	COG1252	NADH dehydrogenase
HEQ12_10015	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEQ12_10025	COG1785	Belongs to the alkaline phosphatase family
HEQ12_10030	COG1487	ribonuclease activity
HEQ12_10045	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEQ12_10065	COG0525	valine-tRNA ligase activity
HEQ12_10085	COG1054	Belongs to the UPF0176 family
HEQ12_10090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEQ12_10090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEQ12_10110	COG1487	ribonuclease activity
HEQ12_10120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEQ12_10135	COG0037	tRNA processing
HEQ12_10145	COG0784	Response regulator, receiver
HEQ12_10165	COG0643	Histidine kinase
HEQ12_10165	COG0784	Response regulator, receiver
HEQ12_10165	COG2198	Histidine kinase
HEQ12_10165	COG2198	Histidine kinase
HEQ12_10165	COG0784	Response regulator, receiver
HEQ12_10165	COG0643	Histidine kinase
HEQ12_10170	COG1007	ATP synthesis coupled electron transport
HEQ12_10175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ12_10190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEQ12_10205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEQ12_10210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEQ12_10215	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HEQ12_10230	COG2839	Protein conserved in bacteria
HEQ12_10240	COG0516	GMP reductase activity
HEQ12_10240	COG0517	IMP dehydrogenase activity
HEQ12_10245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEQ12_10245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEQ12_10250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEQ12_10255	COG1649	PFAM Uncharacterised BCR, COG1649
HEQ12_10270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEQ12_10275	COG0047	phosphoribosylformylglycinamidine synthase activity
HEQ12_10285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEQ12_10290	COG0735	belongs to the Fur family
HEQ12_10295	COG0330	HflC and HflK could
HEQ12_10315	COG2091	lysine biosynthetic process via aminoadipic acid
HEQ12_10320	COG0429	hydrolase of the alpha beta-hydrolase fold
HEQ12_10325	COG0745	RESPONSE REGULATOR receiver
HEQ12_10330	COG1160	GTP binding
HEQ12_10335	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEQ12_10340	COG0802	atpase or kinase
HEQ12_10345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEQ12_10350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HEQ12_10360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEQ12_10370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEQ12_10385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEQ12_10385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEQ12_10400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEQ12_10410	COG1845	cytochrome c oxidase, subunit III
HEQ12_10415	COG0402	S-adenosylhomocysteine deaminase activity
HEQ12_10455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HEQ12_10490	COG0189	ligase activity
HEQ12_10490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEQ12_10495	COG4242	Belongs to the peptidase S51 family
HEQ12_10500	COG0336	Belongs to the RNA methyltransferase TrmD family
HEQ12_10505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEQ12_10520	COG4166	transmembrane transport
HEQ12_10525	COG1691	(AIR) carboxylase
HEQ12_10535	COG0165	Argininosuccinate lyase
HEQ12_10545	COG1185	polyribonucleotide nucleotidyltransferase activity
HEQ12_10565	COG0515	serine threonine protein kinase
HEQ12_10570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEQ12_10575	COG0484	heat shock protein binding
HEQ12_10585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEQ12_10590	COG3437	response regulator, receiver
HEQ12_10610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEQ12_10620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEQ12_10625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEQ12_10630	COG1304	FMN binding
HEQ12_10635	COG0616	signal peptide processing
HEQ12_10685	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HEQ12_10685	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HEQ12_10700	COG0784	Response regulator, receiver
HEQ12_10700	COG2205	protein histidine kinase activity
HEQ12_10715	COG0019	diaminopimelate decarboxylase activity
HEQ12_10730	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEQ12_10730	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEQ12_10730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEQ12_10730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEQ12_10755	COG2205	protein histidine kinase activity
HEQ12_10760	COG0589	response to stress
HEQ12_10780	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_10790	COG3259	Nickel-dependent hydrogenase
HEQ12_10805	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEQ12_10805	COG1024	Enoyl-CoA hydratase
HEQ12_10810	COG0183	Belongs to the thiolase family
HEQ12_10815	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ12_10820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEQ12_10825	COG3243	poly(R)-hydroxyalkanoic acid synthase
HEQ12_10835	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ12_10840	COG0572	uridine kinase
HEQ12_10855	COG1215	transferase activity, transferring glycosyl groups
HEQ12_10900	COG0857	belongs to the CobB CobQ family
HEQ12_10910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEQ12_10940	COG0577	efflux transmembrane transporter activity
HEQ12_10940	COG1136	(ABC) transporter
HEQ12_11025	COG1657	PFAM Prenyltransferase squalene oxidase
HEQ12_11035	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HEQ12_11040	COG0830	nickel cation binding
HEQ12_11045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEQ12_11060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEQ12_11070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEQ12_11075	COG0798	PFAM Bile acid sodium symporter
HEQ12_11085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEQ12_11090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEQ12_11110	COG1136	(ABC) transporter
HEQ12_11115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEQ12_11140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEQ12_11155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEQ12_11160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEQ12_11165	COG3118	belongs to the thioredoxin family
HEQ12_11180	COG0656	L-ascorbic acid biosynthetic process
HEQ12_11195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEQ12_11205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ12_11210	COG0003	Pfam Anion-transporting ATPase
HEQ12_11295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEQ12_11305	COG1575	Belongs to the MenA family. Type 1 subfamily
HEQ12_11315	COG0318	PFAM AMP-dependent synthetase and ligase
HEQ12_11330	COG2337	Toxic component of a toxin-antitoxin (TA) module
HEQ12_11355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HEQ12_11370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HEQ12_11385	COG0495	leucyl-tRNA aminoacylation
HEQ12_11405	COG0515	serine threonine protein kinase
HEQ12_11405	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_11410	COG3311	Transcriptional regulator
HEQ12_11420	COG1063	alcohol dehydrogenase
HEQ12_11445	COG0438	transferase activity, transferring glycosyl groups
HEQ12_11485	COG2890	protein-(glutamine-N5) methyltransferase activity
HEQ12_11515	COG0003	Pfam Anion-transporting ATPase
HEQ12_11520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEQ12_11540	COG0316	Belongs to the HesB IscA family
HEQ12_11555	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEQ12_11580	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEQ12_11580	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEQ12_11580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEQ12_11580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEQ12_11590	COG0205	6-phosphofructokinase activity
HEQ12_11600	COG0454	-acetyltransferase
HEQ12_11605	COG2267	carboxylic ester hydrolase activity
HEQ12_11610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEQ12_11630	COG0194	GDP metabolic process
HEQ12_11660	COG0739	heme binding
HEQ12_11665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEQ12_11670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEQ12_11685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEQ12_11690	COG0713	ATP synthesis coupled electron transport
HEQ12_11695	COG0839	Belongs to the complex I subunit 6 family
HEQ12_11700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_11705	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEQ12_11710	COG0372	Belongs to the citrate synthase family
HEQ12_11715	COG2062	phosphohistidine phosphatase, SixA
HEQ12_11735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEQ12_11780	COG1943	Transposase
HEQ12_11800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEQ12_11810	COG0574	Belongs to the PEP-utilizing enzyme family
HEQ12_11810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEQ12_11815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEQ12_11825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HEQ12_11835	COG0242	peptide deformylase activity
HEQ12_11850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HEQ12_11850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HEQ12_11865	COG2052	Domain of unknown function (DUF370)
HEQ12_11890	COG0142	geranyltranstransferase activity
HEQ12_11900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HEQ12_11905	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEQ12_11910	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEQ12_11915	COG0475	glutathione-regulated potassium exporter activity
HEQ12_11935	COG0629	single-stranded DNA binding
HEQ12_11940	COG1077	Cell shape determining protein MreB Mrl
HEQ12_11955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEQ12_11960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ12_11970	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HEQ12_11980	COG0612	Peptidase, M16
HEQ12_11985	COG0612	Peptidase, M16
HEQ12_12005	COG0602	queuosine metabolic process
HEQ12_12040	COG4783	chaperone-mediated protein folding
HEQ12_12055	COG0617	tRNA 3'-terminal CCA addition
HEQ12_12065	COG1214	PFAM Peptidase M22, glycoprotease
HEQ12_12100	COG0732	type I restriction modification DNA specificity domain
HEQ12_12110	COG5002	protein histidine kinase activity
HEQ12_12135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEQ12_12170	COG1487	ribonuclease activity
HEQ12_12180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEQ12_12185	COG0750	zinc metalloprotease
HEQ12_12220	COG0751	glycine-tRNA ligase activity
HEQ12_12225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEQ12_12260	COG0156	8-amino-7-oxononanoate synthase activity
HEQ12_12265	COG0632	four-way junction helicase activity
HEQ12_12270	COG0561	phosphatase activity
HEQ12_12305	COG1247	-acetyltransferase
HEQ12_12335	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HEQ12_12355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEQ12_12360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEQ12_12375	COG1468	defense response to virus
HEQ12_12375	COG1518	maintenance of DNA repeat elements
HEQ12_12420	COG1979	alcohol dehydrogenase
HEQ12_12425	COG0765	amino acid transport
HEQ12_12430	COG1193	negative regulation of DNA recombination
HEQ12_12445	COG2208	phosphoserine phosphatase activity
HEQ12_12450	COG0552	protein localization to endoplasmic reticulum
HEQ12_12455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEQ12_12460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEQ12_12480	COG0259	pyridoxamine-phosphate oxidase activity
HEQ12_12485	COG0628	permease
HEQ12_12495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEQ12_12505	COG1166	arginine decarboxylase activity
HEQ12_12510	COG0105	UTP biosynthetic process
HEQ12_12515	COG1006	Multisubunit Na H antiporter MnhC subunit
HEQ12_12525	COG0651	ATP synthesis coupled electron transport
HEQ12_12555	COG0861	Integral membrane protein TerC family
HEQ12_12565	COG0745	RESPONSE REGULATOR receiver
HEQ12_12585	COG0419	ATPase involved in DNA repair
HEQ12_12610	COG4581	dead DEAH box helicase
HEQ12_12620	COG2267	carboxylic ester hydrolase activity
HEQ12_12655	COG0752	glycyl-tRNA synthetase alpha subunit
HEQ12_12665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEQ12_12675	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEQ12_12680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEQ12_12685	COG3842	ATPase activity
HEQ12_12690	COG0768	penicillin binding
HEQ12_12695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEQ12_12710	COG0215	cysteine-tRNA ligase activity
HEQ12_12725	COG5002	protein histidine kinase activity
HEQ12_12735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEQ12_12760	COG0390	transport system, permease component
HEQ12_12765	COG0515	serine threonine protein kinase
HEQ12_12765	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_12770	COG1012	belongs to the aldehyde dehydrogenase family
HEQ12_12780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEQ12_12785	COG2223	nitrite transmembrane transporter activity
HEQ12_12795	COG2267	carboxylic ester hydrolase activity
HEQ12_12800	COG1981	membrane
HEQ12_12810	COG0284	orotidine-5'-phosphate decarboxylase activity
HEQ12_12855	COG1032	radical SAM domain protein
HEQ12_12900	COG0824	Thioesterase
HEQ12_12915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HEQ12_12940	COG3385	transposase activity
HEQ12_12955	COG0445	tRNA wobble uridine modification
HEQ12_12980	COG0006	proline dipeptidase activity
HEQ12_13005	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HEQ12_13035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ12_13055	COG1446	asparaginase
HEQ12_13060	COG0514	ATP-dependent DNA helicase (RecQ)
HEQ12_13070	COG1122	ATPase activity
HEQ12_13080	COG0310	cobalt ion transport
HEQ12_13100	COG4115	mRNA cleavage
HEQ12_13115	COG2132	Multicopper oxidase
HEQ12_13145	COG0672	)-iron permease
HEQ12_13155	COG0740	serine-type endopeptidase activity
HEQ12_13165	COG0557	exoribonuclease II activity
HEQ12_13170	COG0163	prenyltransferase activity
HEQ12_13195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEQ12_13250	COG1215	transferase activity, transferring glycosyl groups
HEQ12_13255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEQ12_13325	COG0360	Binds together with S18 to 16S ribosomal RNA
HEQ12_13330	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEQ12_13345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEQ12_13365	COG3385	transposase activity
HEQ12_13405	COG4172	Belongs to the ABC transporter superfamily
HEQ12_13420	COG0354	folic acid binding
HEQ12_13425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEQ12_13445	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HEQ12_13450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEQ12_13465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEQ12_13510	COG3429	Glucose-6-phosphate dehydrogenase subunit
HEQ12_13510	COG3409	Peptidoglycan-binding domain 1 protein
HEQ12_13515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEQ12_13520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HEQ12_13525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEQ12_13530	COG0300	oxidoreductase activity
HEQ12_13535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEQ12_13560	COG1895	HEPN domain
HEQ12_13575	COG0515	serine threonine protein kinase
HEQ12_13575	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_13600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEQ12_13615	COG0531	amino acid
HEQ12_13635	COG3781	membrane
HEQ12_13645	COG1672	PFAM Archaeal ATPase
HEQ12_13645	COG2319	Wd-40 repeat
HEQ12_13665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEQ12_13670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HEQ12_13685	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEQ12_13705	COG0463	Glycosyl transferase, family 2
HEQ12_13740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEQ12_13755	COG4555	ABC transporter
HEQ12_13760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEQ12_13765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEQ12_13770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEQ12_13780	COG3977	Valine--pyruvate aminotransferase
HEQ12_13785	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEQ12_13790	COG0616	signal peptide processing
HEQ12_13810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEQ12_13855	COG0460	homoserine dehydrogenase
HEQ12_13860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEQ12_13865	COG0572	uridine kinase
HEQ12_13890	COG1404	Belongs to the peptidase S8 family
HEQ12_13895	COG2319	Wd-40 repeat
HEQ12_13895	COG1672	PFAM Archaeal ATPase
HEQ12_13905	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ12_13915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEQ12_13935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEQ12_13940	COG1045	serine acetyltransferase
HEQ12_13955	COG1054	Belongs to the UPF0176 family
HEQ12_13960	COG1420	regulation of RNA biosynthetic process
HEQ12_13985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEQ12_13990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEQ12_13995	COG2988	succinylglutamate desuccinylase activity
HEQ12_14000	COG0438	transferase activity, transferring glycosyl groups
HEQ12_14015	COG1410	methionine synthase
HEQ12_14015	COG0646	methionine synthase
HEQ12_14020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HEQ12_14025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEQ12_14030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HEQ12_14035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEQ12_14040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEQ12_14045	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEQ12_14095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEQ12_14105	COG0501	Belongs to the peptidase M48B family
HEQ12_14110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEQ12_14115	COG0321	lipoyl(octanoyl) transferase activity
HEQ12_14120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEQ12_14125	COG0009	L-threonylcarbamoyladenylate synthase
HEQ12_14130	COG5002	protein histidine kinase activity
HEQ12_14135	COG0454	-acetyltransferase
HEQ12_14145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEQ12_14150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEQ12_14155	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEQ12_14155	COG0022	dehydrogenase e1 component
HEQ12_14170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEQ12_14180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HEQ12_14195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEQ12_14205	COG0151	Belongs to the GarS family
HEQ12_14225	COG4115	mRNA cleavage
HEQ12_14245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEQ12_14280	COG0724	RNA recognition motif
HEQ12_14295	COG0537	adenosine 5'-monophosphoramidase activity
HEQ12_14365	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ12_14370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HEQ12_14395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEQ12_14400	COG0193	aminoacyl-tRNA hydrolase activity
HEQ12_14410	COG2205	protein histidine kinase activity
HEQ12_14410	COG3437	response regulator, receiver
HEQ12_14410	COG4999	Histidine kinase
HEQ12_14410	COG3850	Histidine kinase
HEQ12_14420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEQ12_14440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEQ12_14455	COG4956	integral membrane protein (PIN domain superfamily)
HEQ12_14460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEQ12_14480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEQ12_14500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEQ12_14510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEQ12_14515	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HEQ12_14535	COG2205	protein histidine kinase activity
HEQ12_14545	COG1230	cation diffusion facilitator family transporter
HEQ12_14575	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HEQ12_14580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEQ12_14585	COG2264	protein methyltransferase activity
HEQ12_14590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEQ12_14595	COG0010	Belongs to the arginase family
HEQ12_14600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEQ12_14605	COG3237	CsbD-like
HEQ12_14610	COG2823	Periplasmic or secreted lipoprotein
HEQ12_14620	COG3237	CsbD-like
HEQ12_14625	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HEQ12_14635	COG1132	(ABC) transporter
HEQ12_14650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEQ12_14655	COG0673	inositol 2-dehydrogenase activity
HEQ12_14660	COG0024	Methionine aminopeptidase
HEQ12_14680	COG2274	protein secretion by the type I secretion system
HEQ12_14695	COG0137	argininosuccinate synthase activity
HEQ12_14700	COG1216	Glycosyl transferase, family 2
HEQ12_14735	COG0443	Heat shock 70 kDa protein
HEQ12_14740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HEQ12_14765	COG2082	Precorrin-8x methylmutase
HEQ12_14790	COG1940	carbohydrate kinase activity
HEQ12_14805	COG1836	PFAM Integral membrane protein DUF92
HEQ12_14810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEQ12_14895	COG3266	domain, Protein
HEQ12_14895	COG0515	serine threonine protein kinase
HEQ12_14900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEQ12_14910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEQ12_14920	COG0438	transferase activity, transferring glycosyl groups
HEQ12_15005	COG0469	pyruvate kinase activity
HEQ12_15035	COG1091	dTDP-4-dehydrorhamnose reductase activity
HEQ12_15065	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEQ12_15075	COG0133	tryptophan synthase activity
HEQ12_15135	COG1253	flavin adenine dinucleotide binding
HEQ12_15150	COG0237	dephospho-CoA kinase activity
HEQ12_15160	COG0745	RESPONSE REGULATOR receiver
HEQ12_15180	COG0395	ABC-type sugar transport system, permease component
HEQ12_15190	COG3385	transposase activity
HEQ12_15225	COG0515	serine threonine protein kinase
HEQ12_15230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ12_15240	COG0515	serine threonine protein kinase
HEQ12_15270	COG4232	protein-disulfide reductase activity
HEQ12_15275	COG1333	cytochrome c biogenesis protein
HEQ12_15280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEQ12_15285	COG0745	RESPONSE REGULATOR receiver
HEQ12_15290	COG0432	Pfam Uncharacterised protein family UPF0047
HEQ12_15305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEQ12_15325	COG0601	transmembrane transport
HEQ12_15345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEQ12_15365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEQ12_15370	COG3118	belongs to the thioredoxin family
HEQ12_15380	COG0583	DNA-binding transcription factor activity
HEQ12_15385	COG0515	serine threonine protein kinase
HEQ12_15390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEQ12_15395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEQ12_15405	COG0561	phosphatase activity
HEQ12_15410	COG0124	histidyl-tRNA synthetase
HEQ12_15415	COG0737	Belongs to the 5'-nucleotidase family
HEQ12_15425	COG4636	protein conserved in cyanobacteria
HEQ12_15435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEQ12_15450	COG0644	oxidoreductase
HEQ12_15455	COG4636	protein conserved in cyanobacteria
HEQ12_15470	COG2423	ornithine cyclodeaminase activity
HEQ12_15485	COG0300	oxidoreductase activity
HEQ12_15490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEQ12_15490	COG3320	Male sterility
HEQ12_15495	COG2070	2-Nitropropane dioxygenase
HEQ12_15495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEQ12_15500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEQ12_15500	COG0300	oxidoreductase activity
HEQ12_15500	COG3321	synthase
HEQ12_15500	COG4221	oxidoreductase activity
HEQ12_15510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEQ12_15510	COG4221	oxidoreductase activity
HEQ12_15510	COG3321	synthase
HEQ12_15510	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ12_15515	COG0604	alcohol dehydrogenase
HEQ12_15515	COG3321	synthase
HEQ12_15555	COG1450	Type ii and iii secretion system protein
HEQ12_15580	COG0285	dihydrofolate synthase activity
HEQ12_15605	COG0612	Peptidase, M16
HEQ12_15610	COG0024	Methionine aminopeptidase
HEQ12_15630	COG0438	transferase activity, transferring glycosyl groups
HEQ12_15640	COG1381	Involved in DNA repair and RecF pathway recombination
HEQ12_15645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HEQ12_15655	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEQ12_15670	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEQ12_15675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEQ12_15695	COG0586	Pfam SNARE associated Golgi protein
HEQ12_15700	COG1132	(ABC) transporter
HEQ12_15720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEQ12_15725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEQ12_15730	COG0494	nUDIX hydrolase
HEQ12_15740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ12_15745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEQ12_15750	COG0783	Belongs to the Dps family
HEQ12_15775	COG0584	glycerophosphoryl diester phosphodiesterase
HEQ12_15795	COG1472	Belongs to the glycosyl hydrolase 3 family
HEQ12_15800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEQ12_15805	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEQ12_15805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEQ12_15810	COG1562	ergosterol biosynthetic process
HEQ12_15830	COG0071	Belongs to the small heat shock protein (HSP20) family
HEQ12_15860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HEQ12_15875	COG1218	3'(2'),5'-bisphosphate nucleotidase
HEQ12_15880	COG0724	RNA recognition motif
HEQ12_15885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HEQ12_15960	COG0489	protein tyrosine kinase activity
HEQ12_16075	COG3609	addiction module antidote protein, CC2985 family
HEQ12_16120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEQ12_16125	COG0772	Belongs to the SEDS family
HEQ12_16145	COG0837	glucose binding
HEQ12_16155	COG0436	Aminotransferase
HEQ12_16190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEQ12_16220	COG0411	ABC transporter
HEQ12_16230	COG0072	phenylalanine-tRNA ligase activity
HEQ12_16230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEQ12_16235	COG1132	(ABC) transporter
HEQ12_16245	COG0829	nickel cation binding
HEQ12_16250	COG0831	urea catabolic process
HEQ12_16255	COG0832	Belongs to the urease beta subunit family
HEQ12_16260	COG0804	urea catabolic process
HEQ12_16265	COG1741	Belongs to the pirin family
HEQ12_16295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEQ12_16295	COG2022	thiamine diphosphate biosynthetic process
HEQ12_16305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEQ12_16310	COG3794	PFAM blue (type 1) copper domain protein
HEQ12_16320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEQ12_16340	COG0799	negative regulation of ribosome biogenesis
HEQ12_16360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEQ12_16375	COG4451	ribulose bisphosphate carboxylase, small
HEQ12_16385	COG1850	ribulose-bisphosphate carboxylase activity
HEQ12_16390	COG1104	cysteine desulfurase activity
HEQ12_16395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEQ12_16400	COG0284	orotidine-5'-phosphate decarboxylase activity
HEQ12_16400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEQ12_16425	COG1252	NADH dehydrogenase
HEQ12_16445	COG0489	protein tyrosine kinase activity
HEQ12_16450	COG2385	sporulation resulting in formation of a cellular spore
HEQ12_16475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEQ12_16490	COG1205	dead DEAH box helicase
HEQ12_16490	COG1111	helicase
HEQ12_16495	COG1160	GTP binding
HEQ12_16515	COG1473	amidohydrolase
HEQ12_16530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEQ12_16535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HEQ12_16540	COG1959	2 iron, 2 sulfur cluster binding
HEQ12_16550	COG0038	chloride channel
HEQ12_16630	COG1196	nuclear chromosome segregation
HEQ12_16655	COG2886	Uncharacterised protein family (UPF0175)
HEQ12_16695	COG0542	response to heat
HEQ12_16705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEQ12_16710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_16740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEQ12_16775	COG0017	Asparaginyl-tRNA synthetase
HEQ12_16795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEQ12_16830	COG1702	phosphate starvation-inducible protein PhoH
HEQ12_16840	COG0228	four-way junction DNA binding
HEQ12_16865	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HEQ12_16870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEQ12_16890	COG0352	thiamine-phosphate diphosphorylase activity
HEQ12_16900	COG0443	Heat shock 70 kDa protein
HEQ12_16910	COG0631	protein serine/threonine phosphatase activity
HEQ12_16915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEQ12_16920	COG3937	granule-associated protein
HEQ12_16930	COG2267	carboxylic ester hydrolase activity
HEQ12_16985	COG1696	Membrane protein involved in D-alanine export
HEQ12_17000	COG0371	Dehydrogenase
HEQ12_17005	COG0436	Aminotransferase
HEQ12_17010	COG0473	3-isopropylmalate dehydrogenase activity
HEQ12_17020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HEQ12_17025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEQ12_17065	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEQ12_17100	COG0515	serine threonine protein kinase
HEQ12_17115	COG0439	Biotin carboxylase
HEQ12_17130	COG3266	domain, Protein
HEQ12_17130	COG0515	serine threonine protein kinase
HEQ12_17135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ12_17145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ12_17160	COG0393	Putative heavy-metal-binding
HEQ12_17170	COG2226	methyltransferase
HEQ12_17180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEQ12_17205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEQ12_17250	COG0746	molybdenum cofactor guanylyltransferase activity
HEQ12_17260	COG2501	S4 domain
HEQ12_17315	COG0375	protein maturation
HEQ12_17355	COG0409	Hydrogenase expression formation protein
HEQ12_17365	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEQ12_17420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEQ12_17425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEQ12_17430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ12_17435	COG0735	belongs to the Fur family
HEQ12_17445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HEQ12_17455	COG0732	type I restriction modification DNA specificity domain
HEQ12_17480	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HEQ12_17485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEQ12_17510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEQ12_17535	COG0459	protein refolding
HEQ12_17540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEQ12_17545	COG0745	RESPONSE REGULATOR receiver
HEQ12_17550	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HEQ12_17570	COG0346	lactoylglutathione lyase activity
HEQ12_17575	COG0542	response to heat
HEQ12_17610	COG1192	Involved in chromosome partitioning
HEQ12_17620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEQ12_17630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEQ12_17635	COG0052	Belongs to the universal ribosomal protein uS2 family
HEQ12_17640	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEQ12_17650	COG0517	IMP dehydrogenase activity
HEQ12_17650	COG0617	tRNA 3'-terminal CCA addition
HEQ12_17650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HEQ12_17660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEQ12_17675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEQ12_17710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HEQ12_17715	COG0088	Forms part of the polypeptide exit tunnel
HEQ12_17720	COG0089	rRNA binding
HEQ12_17725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEQ12_17730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEQ12_17735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEQ12_17740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEQ12_17745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEQ12_17750	COG0255	Belongs to the universal ribosomal protein uL29 family
HEQ12_17755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEQ12_17760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEQ12_17765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEQ12_17770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEQ12_17775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEQ12_17780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEQ12_17785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEQ12_17790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEQ12_17795	COG0200	Binds to the 23S rRNA
HEQ12_17800	COG0201	protein transport
HEQ12_17805	COG0563	adenylate kinase activity
HEQ12_17810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEQ12_17815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HEQ12_17820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEQ12_17825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEQ12_17830	COG0202	RNA polymerase activity
HEQ12_17835	COG0203	ribosomal protein L17
HEQ12_17840	COG0101	tRNA pseudouridine synthase activity
HEQ12_17845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEQ12_17850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HEQ12_17855	COG0254	rRNA binding
HEQ12_17860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEQ12_17875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEQ12_17880	COG0581	inorganic phosphate transmembrane transporter activity
HEQ12_17885	COG0573	inorganic phosphate transmembrane transporter activity
HEQ12_17890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEQ12_17895	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEQ12_17900	COG2894	cell division
HEQ12_17905	COG0850	regulation of cytokinetic process
HEQ12_17915	COG0793	Belongs to the peptidase S41A family
HEQ12_17935	COG1335	isochorismatase
HEQ12_17970	COG0076	glutamate decarboxylase activity
HEQ12_17975	COG0012	GTP binding
HEQ12_18000	COG1982	Orn Lys Arg decarboxylase major
HEQ12_18005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEQ12_18010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HEQ12_18015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEQ12_18020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEQ12_18035	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HEQ12_18060	COG4279	zinc finger
HEQ12_18090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEQ12_18095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEQ12_18100	COG0509	glycine decarboxylation via glycine cleavage system
HEQ12_18105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEQ12_18125	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HEQ12_18130	COG3639	organic phosphonate transmembrane transporter activity
HEQ12_18145	COG2198	Histidine kinase
HEQ12_18145	COG0784	Response regulator, receiver
HEQ12_18145	COG0643	Histidine kinase
HEQ12_18180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEQ12_18185	COG0741	lytic transglycosylase activity
HEQ12_18215	COG2234	aminopeptidase activity
HEQ12_18220	COG0443	Heat shock 70 kDa protein
HEQ12_18225	COG0484	heat shock protein binding
HEQ12_18270	COG3385	transposase activity
HEQ12_18275	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ12_18285	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HEQ12_18300	COG0481	GTPase activity
HEQ12_18315	COG0793	Belongs to the peptidase S41A family
HEQ12_18325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEQ12_18345	COG0019	diaminopimelate decarboxylase activity
HEQ12_18350	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HEQ12_18355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEQ12_18365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HEQ12_18365	COG3266	domain, Protein
HEQ12_18380	COG0195	Participates in both transcription termination and antitermination
HEQ12_18385	COG0779	Required for maturation of 30S ribosomal subunits
HEQ12_18395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HEQ12_18400	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_18410	COG0450	alkyl hydroperoxide reductase
HEQ12_18415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEQ12_18420	COG5398	heme oxygenase
HEQ12_18425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEQ12_18425	COG0426	domain, Protein
HEQ12_18430	COG0426	domain, Protein
HEQ12_18430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEQ12_18440	COG3850	Histidine kinase
HEQ12_18440	COG3437	response regulator, receiver
HEQ12_18440	COG2205	protein histidine kinase activity
HEQ12_18440	COG4999	Histidine kinase
HEQ12_18445	COG0784	Response regulator, receiver
HEQ12_18450	COG4251	negative regulation of phosphorylation
HEQ12_18465	COG0312	modulator of DNA gyrase
HEQ12_18470	COG0312	modulator of DNA gyrase
HEQ12_18485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ12_18495	COG0438	transferase activity, transferring glycosyl groups
HEQ12_18505	COG3842	ATPase activity
HEQ12_18510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ12_18515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEQ12_18520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ12_18520	COG1116	anion transmembrane transporter activity
HEQ12_18525	COG1116	anion transmembrane transporter activity
HEQ12_18540	COG4636	protein conserved in cyanobacteria
HEQ12_18560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEQ12_18575	COG3744	PilT protein domain protein
HEQ12_18585	COG0463	Glycosyl transferase, family 2
HEQ12_18625	COG0070	glutamate synthase
HEQ12_18625	COG0069	glutamate synthase activity
HEQ12_18625	COG0067	glutamate synthase
HEQ12_18635	COG0662	Cupin 2, conserved barrel domain protein
HEQ12_18635	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HEQ12_18640	COG0316	Belongs to the HesB IscA family
HEQ12_18645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEQ12_18650	COG0049	tRNA binding
HEQ12_18655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEQ12_18660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEQ12_18665	COG0051	transcription antitermination factor activity, RNA binding
HEQ12_18670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEQ12_18675	COG0724	RNA recognition motif
HEQ12_18690	COG3385	transposase activity
HEQ12_18695	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HEQ12_18700	COG0009	L-threonylcarbamoyladenylate synthase
HEQ12_18720	COG0719	Fe-S assembly protein
HEQ12_18725	COG0396	ATPase activity
HEQ12_18730	COG0719	Fe-S assembly protein
HEQ12_18735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEQ12_18745	COG1049	propionate catabolic process, 2-methylcitrate cycle
HEQ12_18750	COG3385	transposase activity
HEQ12_18795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEQ12_18800	COG1716	ATPase activity
HEQ12_18805	COG0363	glucosamine-6-phosphate deaminase activity
HEQ12_18810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEQ12_18815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEQ12_18825	COG4658	electron transport chain
HEQ12_18855	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_18860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEQ12_18865	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ12_18870	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ12_18875	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HEQ12_18880	COG4451	ribulose bisphosphate carboxylase, small
HEQ12_18880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEQ12_18885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEQ12_18890	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ12_18900	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HEQ12_18910	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HEQ12_18920	COG3239	Fatty acid desaturase
HEQ12_18960	COG0475	glutathione-regulated potassium exporter activity
HEQ12_18970	COG0463	Glycosyl transferase, family 2
HEQ12_18975	COG0793	Belongs to the peptidase S41A family
HEQ12_18980	COG0515	serine threonine protein kinase
HEQ12_18980	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_19010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEQ12_19015	COG0581	inorganic phosphate transmembrane transporter activity
HEQ12_19035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEQ12_19040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEQ12_19055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEQ12_19060	COG0601	transmembrane transport
HEQ12_19075	COG3239	Fatty acid desaturase
HEQ12_19125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HEQ12_19125	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HEQ12_19155	COG2373	Large extracellular alpha-helical protein
HEQ12_19160	COG4953	penicillin-binding protein 1C
HEQ12_19185	COG1002	Type II restriction enzyme, methylase subunits
HEQ12_19195	COG0571	ribonuclease III activity
HEQ12_19200	COG1672	PFAM Archaeal ATPase
HEQ12_19205	COG0724	RNA recognition motif
HEQ12_19215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEQ12_19225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEQ12_19230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEQ12_19250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEQ12_19280	COG0515	serine threonine protein kinase
HEQ12_19290	COG3266	domain, Protein
HEQ12_19290	COG2911	Protein conserved in bacteria
HEQ12_19290	COG1361	Conserved repeat domain
HEQ12_19295	COG0542	response to heat
HEQ12_19300	COG4636	protein conserved in cyanobacteria
HEQ12_19325	COG2081	HI0933 family
HEQ12_19330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEQ12_19335	COG0848	biopolymer transport protein
HEQ12_19340	COG0811	peptide transport
HEQ12_19355	COG2890	protein-(glutamine-N5) methyltransferase activity
HEQ12_19400	COG3956	TIGRFAM MazG family protein
HEQ12_19405	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEQ12_19415	COG0515	serine threonine protein kinase
HEQ12_19415	COG2815	serine threonine protein kinase
HEQ12_19420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEQ12_19425	COG0745	RESPONSE REGULATOR receiver
HEQ12_19445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEQ12_19450	COG0271	Belongs to the BolA IbaG family
HEQ12_19460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ12_19475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ12_19480	COG1937	Protein conserved in bacteria
HEQ12_19490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEQ12_19505	COG0768	penicillin binding
HEQ12_19530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEQ12_19550	COG0318	PFAM AMP-dependent synthetase and ligase
HEQ12_19555	COG1136	(ABC) transporter
HEQ12_19555	COG0577	efflux transmembrane transporter activity
HEQ12_19565	COG0564	pseudouridine synthase activity
HEQ12_19575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEQ12_19580	COG3903	Transcriptional regulator
HEQ12_19580	COG2319	Wd-40 repeat
HEQ12_19615	COG5499	transcription regulator containing HTH domain
HEQ12_19635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEQ12_19640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEQ12_19645	COG0587	DNA-directed DNA polymerase activity
HEQ12_19660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEQ12_19665	COG3119	arylsulfatase activity
HEQ12_19675	COG0539	negative regulation of cytoplasmic translation
HEQ12_19680	COG0412	Dienelactone hydrolase
HEQ12_19685	COG2188	Transcriptional regulator
HEQ12_19710	COG1950	PFAM Membrane protein of
HEQ12_19730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEQ12_19740	COG0066	3-isopropylmalate dehydratase activity
HEQ12_19755	COG2326	polyphosphate kinase activity
HEQ12_19775	COG1797	cobyrinic acid a,c-diamide synthase activity
HEQ12_19780	COG1615	UPF0182 protein
HEQ12_19810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEQ12_19830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEQ12_19845	COG5002	protein histidine kinase activity
HEQ12_19850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEQ12_19870	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ12_19870	COG0515	serine threonine protein kinase
HEQ12_19885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEQ12_19890	COG0335	large ribosomal subunit rRNA binding
HEQ12_19900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEQ12_19905	COG0250	Participates in transcription elongation, termination and antitermination
HEQ12_19910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEQ12_19915	COG0081	regulation of translation
HEQ12_19920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEQ12_19925	COG0222	ribosome binding
HEQ12_19930	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEQ12_19930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEQ12_19950	COG0583	DNA-binding transcription factor activity
HEQ12_19965	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEQ12_19970	COG1494	fructose-1,6-bisphosphatase
HEQ12_20040	COG4245	von Willebrand factor, type A
HEQ12_20045	COG3000	fatty acid hydroxylase
HEQ12_20045	COG0300	oxidoreductase activity
HEQ12_20055	COG1132	(ABC) transporter
HEQ12_20065	COG0488	(ABC) transporter
HEQ12_20110	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HEQ12_20115	COG4251	negative regulation of phosphorylation
HEQ12_20125	COG2205	protein histidine kinase activity
HEQ12_20130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEQ12_20145	COG1072	(Pantothenic acid kinase))
HEQ12_20150	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HEQ12_20160	COG0745	RESPONSE REGULATOR receiver
HEQ12_20205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEQ12_20210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEQ12_20235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEQ12_20245	COG0575	Belongs to the CDS family
HEQ12_20255	COG1187	pseudouridine synthase activity
HEQ12_20260	COG1426	Protein conserved in bacteria
HEQ12_20265	COG1640	4-alpha-glucanotransferase
HEQ12_20270	COG2816	NAD+ diphosphatase activity
HEQ12_20285	COG0251	oxidation-reduction process
HEQ12_20295	COG1316	TRANSCRIPTIONal
HEQ12_20305	COG0628	permease
HEQ12_20310	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HEQ12_20315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HEQ12_20325	COG0745	RESPONSE REGULATOR receiver
HEQ12_20350	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEQ12_20365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ12_20390	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HEQ12_20395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEQ12_20410	COG0686	Belongs to the AlaDH PNT family
HEQ12_20415	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HEQ12_20425	COG1595	DNA-templated transcription, initiation
HEQ12_20430	COG1376	ErfK ybiS ycfS ynhG family protein
HEQ12_20430	COG1388	LysM domain
HEQ12_20435	COG0739	heme binding
HEQ12_20445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEQ12_20450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEQ12_20455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEQ12_20460	COG2048	Heterodisulfide reductase, subunit B
HEQ12_20465	COG0242	peptide deformylase activity
HEQ12_20470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain