locus-tag	class	description
HEQ20_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HEQ20_00030	COG0515	serine threonine protein kinase
HEQ20_00040	COG1187	pseudouridine synthase activity
HEQ20_00050	COG0443	Heat shock 70 kDa protein
HEQ20_00080	COG0237	dephospho-CoA kinase activity
HEQ20_00080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEQ20_00085	COG0489	protein tyrosine kinase activity
HEQ20_00090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEQ20_00110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEQ20_00115	COG0318	PFAM AMP-dependent synthetase and ligase
HEQ20_00120	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ20_00145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEQ20_00165	COG0367	asparagine synthase
HEQ20_00170	COG0438	transferase activity, transferring glycosyl groups
HEQ20_00175	COG0438	transferase activity, transferring glycosyl groups
HEQ20_00185	COG0438	transferase activity, transferring glycosyl groups
HEQ20_00210	COG0440	acetolactate synthase activity
HEQ20_00225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEQ20_00305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ20_00315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEQ20_00330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEQ20_00370	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_00370	COG0515	serine threonine protein kinase
HEQ20_00375	COG1716	ATPase activity
HEQ20_00375	COG1131	(ABC) transporter
HEQ20_00375	COG0842	Transport permease protein
HEQ20_00380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_00395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEQ20_00410	COG0308	aminopeptidase N
HEQ20_00430	COG0488	(ABC) transporter
HEQ20_00435	COG0475	glutathione-regulated potassium exporter activity
HEQ20_00475	COG0670	Belongs to the BI1 family
HEQ20_00490	COG3239	Fatty acid desaturase
HEQ20_00500	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HEQ20_00510	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HEQ20_00550	COG2119	membrane
HEQ20_00575	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HEQ20_00575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HEQ20_00595	COG2373	Large extracellular alpha-helical protein
HEQ20_00600	COG4953	penicillin-binding protein 1C
HEQ20_00645	COG0571	ribonuclease III activity
HEQ20_00655	COG1672	PFAM Archaeal ATPase
HEQ20_00660	COG0724	RNA recognition motif
HEQ20_00665	COG0724	RNA recognition motif
HEQ20_00690	COG0484	heat shock protein binding
HEQ20_00695	COG0443	Heat shock 70 kDa protein
HEQ20_00700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEQ20_00705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEQ20_00715	COG1459	type II secretion system
HEQ20_00750	COG0799	negative regulation of ribosome biogenesis
HEQ20_00770	COG1494	fructose-1,6-bisphosphatase
HEQ20_00775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEQ20_00790	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEQ20_00795	COG0724	RNA recognition motif
HEQ20_00825	COG0402	S-adenosylhomocysteine deaminase activity
HEQ20_00850	COG0598	Magnesium transport protein CorA
HEQ20_00855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEQ20_00920	COG1032	radical SAM domain protein
HEQ20_00925	COG2205	protein histidine kinase activity
HEQ20_00930	COG0784	Response regulator, receiver
HEQ20_00935	COG4251	negative regulation of phosphorylation
HEQ20_00985	COG1252	NADH dehydrogenase
HEQ20_00990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEQ20_01050	COG0328	RNA-DNA hybrid ribonuclease activity
HEQ20_01055	COG1132	(ABC) transporter
HEQ20_01065	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HEQ20_01095	COG0072	phenylalanine-tRNA ligase activity
HEQ20_01095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEQ20_01105	COG3659	wide pore channel activity
HEQ20_01110	COG0411	ABC transporter
HEQ20_01150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEQ20_01165	COG2361	Protein of unknown function DUF86
HEQ20_01195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEQ20_01250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEQ20_01255	COG1121	(ABC) transporter
HEQ20_01260	COG0803	Belongs to the bacterial solute-binding protein 9 family
HEQ20_01265	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HEQ20_01270	COG5398	heme oxygenase
HEQ20_01275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEQ20_01285	COG1994	Peptidase M50
HEQ20_01285	COG0517	IMP dehydrogenase activity
HEQ20_01295	COG0135	phosphoribosylanthranilate isomerase activity
HEQ20_01300	COG0302	gtp cyclohydrolase
HEQ20_01305	COG0300	oxidoreductase activity
HEQ20_01310	COG0825	malonyl-CoA metabolic process
HEQ20_01315	COG5322	oxidoreductase activity
HEQ20_01320	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HEQ20_01340	COG1979	alcohol dehydrogenase
HEQ20_01345	COG0628	permease
HEQ20_01355	COG1051	belongs to the nudix hydrolase family
HEQ20_01365	COG1505	serine-type exopeptidase activity
HEQ20_01370	COG0515	serine threonine protein kinase
HEQ20_01380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_01435	COG1372	Participates in initiation and elongation during chromosome replication
HEQ20_01435	COG0305	Participates in initiation and elongation during chromosome replication
HEQ20_01440	COG0359	binds to the 23S rRNA
HEQ20_01460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEQ20_01470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEQ20_01485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HEQ20_01505	COG3631	Ketosteroid isomerase-related protein
HEQ20_01540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEQ20_01545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEQ20_01555	COG0175	sulfate reduction
HEQ20_01580	COG0784	Response regulator, receiver
HEQ20_01580	COG2205	protein histidine kinase activity
HEQ20_01580	COG5002	protein histidine kinase activity
HEQ20_01605	COG3848	Pyruvate phosphate dikinase
HEQ20_01605	COG0574	Belongs to the PEP-utilizing enzyme family
HEQ20_01620	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HEQ20_01625	COG1518	maintenance of DNA repeat elements
HEQ20_01710	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEQ20_01720	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEQ20_01725	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEQ20_01780	COG0776	regulation of translation
HEQ20_01785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEQ20_01795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEQ20_01810	COG0534	Mate efflux family protein
HEQ20_01815	COG0494	nUDIX hydrolase
HEQ20_01825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEQ20_01830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HEQ20_01830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HEQ20_01870	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HEQ20_01880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEQ20_01885	COG0432	Pfam Uncharacterised protein family UPF0047
HEQ20_01905	COG0561	phosphatase activity
HEQ20_01915	COG2197	response regulator
HEQ20_01930	COG0859	PFAM glycosyl transferase family 9
HEQ20_01935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEQ20_01950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_01965	COG2304	oxidoreductase activity
HEQ20_01970	COG2304	oxidoreductase activity
HEQ20_01990	COG0464	growth
HEQ20_01995	COG1404	Belongs to the peptidase S8 family
HEQ20_02010	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEQ20_02015	COG0298	carbon dioxide binding
HEQ20_02020	COG0409	Hydrogenase expression formation protein
HEQ20_02045	COG0375	protein maturation
HEQ20_02055	COG2226	methyltransferase
HEQ20_02070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEQ20_02095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEQ20_02110	COG0582	viral genome integration into host DNA
HEQ20_02115	COG1943	Transposase
HEQ20_02120	COG1943	Transposase
HEQ20_02125	COG1943	Transposase
HEQ20_02220	COG2337	Toxic component of a toxin-antitoxin (TA) module
HEQ20_02250	COG0210	DNA helicase
HEQ20_02280	COG2501	S4 domain
HEQ20_02290	COG0746	molybdenum cofactor guanylyltransferase activity
HEQ20_02355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_02365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEQ20_02405	COG0563	adenylate kinase activity
HEQ20_02410	COG3118	belongs to the thioredoxin family
HEQ20_02425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEQ20_02430	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEQ20_02445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEQ20_02490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ20_02515	COG0542	response to heat
HEQ20_02535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEQ20_02545	COG3794	PFAM blue (type 1) copper domain protein
HEQ20_02550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEQ20_02555	COG0066	3-isopropylmalate dehydratase activity
HEQ20_02570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEQ20_02590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEQ20_02600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEQ20_02605	COG1799	cell septum assembly
HEQ20_02610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HEQ20_02670	COG1518	maintenance of DNA repeat elements
HEQ20_02670	COG1468	defense response to virus
HEQ20_02685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEQ20_02685	COG3320	Male sterility
HEQ20_02695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEQ20_02695	COG2070	2-Nitropropane dioxygenase
HEQ20_02700	COG3321	synthase
HEQ20_02705	COG3321	synthase
HEQ20_02705	COG0604	alcohol dehydrogenase
HEQ20_02705	COG0604	alcohol dehydrogenase
HEQ20_02705	COG3321	synthase
HEQ20_02725	COG1136	(ABC) transporter
HEQ20_02730	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ20_02740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEQ20_02755	COG0616	signal peptide processing
HEQ20_02765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEQ20_02780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HEQ20_02790	COG2226	methyltransferase
HEQ20_02795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEQ20_02800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEQ20_02815	COG0772	Belongs to the SEDS family
HEQ20_02820	COG0489	protein tyrosine kinase activity
HEQ20_02835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEQ20_02835	COG0515	serine threonine protein kinase
HEQ20_02845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEQ20_02845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEQ20_02865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEQ20_02880	COG0484	heat shock protein binding
HEQ20_02885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEQ20_02890	COG1045	serine acetyltransferase
HEQ20_02905	COG1420	regulation of RNA biosynthetic process
HEQ20_02940	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HEQ20_02940	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HEQ20_02955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEQ20_02990	COG0483	inositol monophosphate 1-phosphatase activity
HEQ20_03020	COG0363	glucosamine-6-phosphate deaminase activity
HEQ20_03025	COG1716	ATPase activity
HEQ20_03030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEQ20_03055	COG1049	propionate catabolic process, 2-methylcitrate cycle
HEQ20_03160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEQ20_03215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEQ20_03220	COG3659	wide pore channel activity
HEQ20_03225	COG0704	Plays a role in the regulation of phosphate uptake
HEQ20_03230	COG5002	protein histidine kinase activity
HEQ20_03235	COG0745	RESPONSE REGULATOR receiver
HEQ20_03265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEQ20_03265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEQ20_03280	COG0167	dihydroorotate dehydrogenase activity
HEQ20_03295	COG1446	asparaginase
HEQ20_03300	COG0514	ATP-dependent DNA helicase (RecQ)
HEQ20_03325	COG1122	ATPase activity
HEQ20_03335	COG0310	cobalt ion transport
HEQ20_03350	COG4115	mRNA cleavage
HEQ20_03400	COG2132	Multicopper oxidase
HEQ20_03415	COG0672	)-iron permease
HEQ20_03420	COG0740	serine-type endopeptidase activity
HEQ20_03430	COG0557	exoribonuclease II activity
HEQ20_03435	COG0163	prenyltransferase activity
HEQ20_03445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEQ20_03460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEQ20_03460	COG0574	Belongs to the PEP-utilizing enzyme family
HEQ20_03465	COG1285	pathogenesis
HEQ20_03485	COG2022	thiamine diphosphate biosynthetic process
HEQ20_03485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEQ20_03500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEQ20_03555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEQ20_03565	COG1696	Membrane protein involved in D-alanine export
HEQ20_03640	COG1943	Transposase
HEQ20_03655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEQ20_03675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEQ20_03675	COG0574	Belongs to the PEP-utilizing enzyme family
HEQ20_03680	COG0469	pyruvate kinase activity
HEQ20_03690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEQ20_03705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HEQ20_03740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEQ20_03745	COG0601	transmembrane transport
HEQ20_03770	COG0438	transferase activity, transferring glycosyl groups
HEQ20_03780	COG0438	transferase activity, transferring glycosyl groups
HEQ20_03785	COG3842	ATPase activity
HEQ20_03825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEQ20_03825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEQ20_03840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEQ20_03860	COG1027	Aspartate ammonia-lyase
HEQ20_03960	COG3561	AntA/AntB antirepressor
HEQ20_04040	COG0438	transferase activity, transferring glycosyl groups
HEQ20_04095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEQ20_04100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEQ20_04105	COG1216	Glycosyl transferase, family 2
HEQ20_04140	COG0003	Pfam Anion-transporting ATPase
HEQ20_04145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEQ20_04210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEQ20_04215	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HEQ20_04225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEQ20_04230	COG0583	DNA-binding transcription factor activity
HEQ20_04240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_04245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEQ20_04255	COG1116	anion transmembrane transporter activity
HEQ20_04255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_04260	COG1116	anion transmembrane transporter activity
HEQ20_04270	COG4636	protein conserved in cyanobacteria
HEQ20_04305	COG1252	NADH dehydrogenase
HEQ20_04325	COG0398	Pfam SNARE associated Golgi protein
HEQ20_04345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEQ20_04385	COG1203	CRISPR-associated helicase, Cas3
HEQ20_04400	COG1324	tolerance protein
HEQ20_04405	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HEQ20_04425	COG1324	tolerance protein
HEQ20_04465	COG1615	UPF0182 protein
HEQ20_04470	COG1797	cobyrinic acid a,c-diamide synthase activity
HEQ20_04480	COG2201	protein-glutamate methylesterase activity
HEQ20_04485	COG2326	polyphosphate kinase activity
HEQ20_04530	COG0675	Transposase, IS605 OrfB family
HEQ20_04545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEQ20_04565	COG2203	Gaf domain
HEQ20_04605	COG0010	Belongs to the arginase family
HEQ20_04615	COG2264	protein methyltransferase activity
HEQ20_04620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEQ20_04625	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HEQ20_04630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEQ20_04660	COG0842	Transport permease protein
HEQ20_04665	COG0842	Transport permease protein
HEQ20_04665	COG1129	ABC transporter
HEQ20_04685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEQ20_04690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEQ20_04695	COG0085	RNA polymerase activity
HEQ20_04700	COG0084	hydrolase, TatD family'
HEQ20_04705	COG0268	Binds directly to 16S ribosomal RNA
HEQ20_04710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEQ20_04730	COG2119	membrane
HEQ20_04740	COG2226	methyltransferase
HEQ20_04765	COG2226	methyltransferase
HEQ20_04770	COG0482	sulfurtransferase activity
HEQ20_04780	COG0424	maF-like protein
HEQ20_04810	COG2886	Uncharacterised protein family (UPF0175)
HEQ20_04855	COG1487	ribonuclease activity
HEQ20_04925	COG0633	Ferredoxin
HEQ20_04930	COG0316	Belongs to the HesB IscA family
HEQ20_04935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEQ20_04945	COG5420	small protein containing a coiled-coil domain
HEQ20_04960	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ20_04965	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ20_04975	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ20_04980	COG0582	viral genome integration into host DNA
HEQ20_04990	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_05045	COG4221	oxidoreductase activity
HEQ20_05060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEQ20_05130	COG3903	Transcriptional regulator
HEQ20_05130	COG2319	Wd-40 repeat
HEQ20_05140	COG1943	Transposase
HEQ20_05145	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ20_05155	COG0582	viral genome integration into host DNA
HEQ20_05250	COG0822	iron-sulfur transferase activity
HEQ20_05250	COG2906	2 iron, 2 sulfur cluster binding
HEQ20_05250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEQ20_05260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEQ20_05280	COG1045	serine acetyltransferase
HEQ20_05300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEQ20_05305	COG5554	nitrogen fixation
HEQ20_05310	COG5554	nitrogen fixation
HEQ20_05335	COG0442	prolyl-tRNA aminoacylation
HEQ20_05340	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_05340	COG0515	serine threonine protein kinase
HEQ20_05365	COG0511	ligase activity, forming carbon-carbon bonds
HEQ20_05370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEQ20_05375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEQ20_05395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEQ20_05400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEQ20_05405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEQ20_05410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEQ20_05415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEQ20_05420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEQ20_05430	COG2442	InterPro IPR007367
HEQ20_05500	COG0358	DNA primase activity
HEQ20_05535	COG2197	response regulator
HEQ20_05540	COG4585	Histidine kinase
HEQ20_05555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ20_05570	COG4572	Cation transport regulator
HEQ20_05575	COG0783	Belongs to the Dps family
HEQ20_05585	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HEQ20_05610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ20_05625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEQ20_05680	COG0793	Belongs to the peptidase S41A family
HEQ20_05690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEQ20_05710	COG0019	diaminopimelate decarboxylase activity
HEQ20_05715	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HEQ20_05720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEQ20_05730	COG0484	heat shock protein binding
HEQ20_05760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEQ20_05765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEQ20_05770	COG0022	dehydrogenase e1 component
HEQ20_05770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEQ20_05795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEQ20_05840	COG1063	alcohol dehydrogenase
HEQ20_05845	COG1569	PIN domain
HEQ20_05850	COG3311	Transcriptional regulator
HEQ20_05855	COG0515	serine threonine protein kinase
HEQ20_05855	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_05910	COG0154	amidase activity
HEQ20_05965	COG1468	defense response to virus
HEQ20_05965	COG1518	maintenance of DNA repeat elements
HEQ20_05985	COG1361	Conserved repeat domain
HEQ20_06000	COG0352	thiamine-phosphate diphosphorylase activity
HEQ20_06005	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_06040	COG0612	Peptidase, M16
HEQ20_06045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HEQ20_06055	COG0322	excinuclease ABC activity
HEQ20_06065	COG1606	tRNA processing
HEQ20_06080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEQ20_06090	COG2897	thiosulfate sulfurtransferase activity
HEQ20_06135	COG0667	Aldo Keto reductase
HEQ20_06150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEQ20_06155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEQ20_06220	COG0625	glutathione transferase activity
HEQ20_06285	COG3344	reverse transcriptase
HEQ20_06365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEQ20_06385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEQ20_06390	COG2873	o-acetylhomoserine
HEQ20_06395	COG0412	Dienelactone hydrolase
HEQ20_06410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_06415	COG0489	protein tyrosine kinase activity
HEQ20_06420	COG4221	oxidoreductase activity
HEQ20_06430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_06440	COG5002	protein histidine kinase activity
HEQ20_06470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEQ20_06490	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ20_06525	COG0778	Nitroreductase
HEQ20_06530	COG1116	anion transmembrane transporter activity
HEQ20_06535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_06540	COG2175	clavaminate synthase activity
HEQ20_06545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_06550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEQ20_06555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEQ20_06560	COG0431	NADPH-dependent FMN reductase
HEQ20_06575	COG0730	response to heat
HEQ20_06605	COG1959	2 iron, 2 sulfur cluster binding
HEQ20_06610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEQ20_06640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEQ20_06680	COG3001	Fructosamine kinase
HEQ20_06690	COG0469	pyruvate kinase activity
HEQ20_06725	COG1091	dTDP-4-dehydrorhamnose reductase activity
HEQ20_06740	COG2770	Histidine kinase
HEQ20_06740	COG3437	response regulator, receiver
HEQ20_06765	COG1959	2 iron, 2 sulfur cluster binding
HEQ20_06775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HEQ20_06780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEQ20_06805	COG1450	Type ii and iii secretion system protein
HEQ20_06840	COG0285	dihydrofolate synthase activity
HEQ20_06865	COG0612	Peptidase, M16
HEQ20_06905	COG0024	Methionine aminopeptidase
HEQ20_06965	COG0322	excinuclease ABC activity
HEQ20_07000	COG1773	rubredoxin
HEQ20_07005	COG2081	HI0933 family
HEQ20_07010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEQ20_07015	COG0848	biopolymer transport protein
HEQ20_07020	COG0811	peptide transport
HEQ20_07035	COG2337	Toxic component of a toxin-antitoxin (TA) module
HEQ20_07095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEQ20_07100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEQ20_07140	COG3903	Transcriptional regulator
HEQ20_07140	COG2319	Wd-40 repeat
HEQ20_07180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEQ20_07200	COG0601	transmembrane transport
HEQ20_07210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEQ20_07215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEQ20_07225	COG0432	Pfam Uncharacterised protein family UPF0047
HEQ20_07230	COG0745	RESPONSE REGULATOR receiver
HEQ20_07235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEQ20_07240	COG1333	cytochrome c biogenesis protein
HEQ20_07245	COG4232	protein-disulfide reductase activity
HEQ20_07275	COG2166	iron-sulfur cluster assembly
HEQ20_07290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEQ20_07300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_07315	COG0271	Belongs to the BolA IbaG family
HEQ20_07320	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEQ20_07335	COG2814	Major facilitator Superfamily
HEQ20_07355	COG0745	RESPONSE REGULATOR receiver
HEQ20_07360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEQ20_07365	COG2815	serine threonine protein kinase
HEQ20_07365	COG0515	serine threonine protein kinase
HEQ20_07375	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEQ20_07380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HEQ20_07385	COG0170	dolichyl monophosphate biosynthetic process
HEQ20_07440	COG0528	UMP kinase activity
HEQ20_07445	COG0233	cytoplasmic translational termination
HEQ20_07450	COG0492	ferredoxin-NADP+ reductase activity
HEQ20_07455	COG0628	permease
HEQ20_07495	COG0516	GMP reductase activity
HEQ20_07500	COG3118	belongs to the thioredoxin family
HEQ20_07540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEQ20_07575	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HEQ20_07580	COG1396	sequence-specific DNA binding
HEQ20_07620	COG0443	Heat shock 70 kDa protein
HEQ20_07625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEQ20_07645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEQ20_07665	COG1672	PFAM Archaeal ATPase
HEQ20_07665	COG2319	Wd-40 repeat
HEQ20_07690	COG0572	uridine kinase
HEQ20_07695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEQ20_07700	COG0460	homoserine dehydrogenase
HEQ20_07705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEQ20_07720	COG4970	Tfp pilus assembly protein FimT
HEQ20_07845	COG1836	PFAM Integral membrane protein DUF92
HEQ20_07860	COG1940	carbohydrate kinase activity
HEQ20_07890	COG2082	Precorrin-8x methylmutase
HEQ20_07900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HEQ20_07945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HEQ20_07955	COG0343	queuine tRNA-ribosyltransferase activity
HEQ20_08030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEQ20_08045	COG0667	Aldo Keto reductase
HEQ20_08050	COG0537	adenosine 5'-monophosphoramidase activity
HEQ20_08060	COG0606	chelatase, subunit chli
HEQ20_08065	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HEQ20_08085	COG0673	inositol 2-dehydrogenase activity
HEQ20_08090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEQ20_08100	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEQ20_08110	COG0133	tryptophan synthase activity
HEQ20_08115	COG0515	serine threonine protein kinase
HEQ20_08115	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_08165	COG0401	homolog of Blt101
HEQ20_08170	COG0023	Translation Initiation Factor
HEQ20_08175	COG2161	toxin-antitoxin pair type II binding
HEQ20_08200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HEQ20_08205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEQ20_08225	COG0768	penicillin binding
HEQ20_08255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEQ20_08265	COG4245	von Willebrand factor, type A
HEQ20_08280	COG2319	Wd-40 repeat
HEQ20_08280	COG4249	Peptidase C14 caspase catalytic subunit p20
HEQ20_08315	COG0191	fructose-bisphosphate aldolase activity
HEQ20_08350	COG1122	ATPase activity
HEQ20_08370	COG0542	response to heat
HEQ20_08380	COG1247	-acetyltransferase
HEQ20_08385	COG0746	molybdenum cofactor guanylyltransferase activity
HEQ20_08390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEQ20_08395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEQ20_08400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEQ20_08405	COG2080	2 iron, 2 sulfur cluster binding
HEQ20_08440	COG1649	PFAM Uncharacterised BCR, COG1649
HEQ20_08450	COG0497	DNA recombination
HEQ20_08480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HEQ20_08485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEQ20_08510	COG0159	tryptophan synthase activity
HEQ20_08525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEQ20_08530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEQ20_08555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEQ20_08615	COG1396	sequence-specific DNA binding
HEQ20_08625	COG4636	protein conserved in cyanobacteria
HEQ20_08630	COG0300	oxidoreductase activity
HEQ20_08655	COG0302	gtp cyclohydrolase
HEQ20_08660	COG0523	cobalamin synthesis protein
HEQ20_08665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEQ20_08680	COG0113	porphobilinogen synthase activity
HEQ20_08685	COG2022	thiamine diphosphate biosynthetic process
HEQ20_08685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEQ20_08700	COG1388	LysM domain
HEQ20_08700	COG1376	ErfK ybiS ycfS ynhG family protein
HEQ20_08705	COG1595	DNA-templated transcription, initiation
HEQ20_08725	COG1192	Involved in chromosome partitioning
HEQ20_08775	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_08790	COG0459	protein refolding
HEQ20_08795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEQ20_08800	COG0745	RESPONSE REGULATOR receiver
HEQ20_08820	COG0829	nickel cation binding
HEQ20_08825	COG0831	urea catabolic process
HEQ20_08840	COG0832	Belongs to the urease beta subunit family
HEQ20_08845	COG0804	urea catabolic process
HEQ20_08860	COG0739	heme binding
HEQ20_08870	COG1131	(ABC) transporter
HEQ20_08880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEQ20_08900	COG0017	Asparaginyl-tRNA synthetase
HEQ20_08920	COG0515	serine threonine protein kinase
HEQ20_08920	COG3266	domain, Protein
HEQ20_09025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEQ20_09140	COG0228	four-way junction DNA binding
HEQ20_09150	COG1702	phosphate starvation-inducible protein PhoH
HEQ20_09245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEQ20_09250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEQ20_09255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEQ20_09260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEQ20_09265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEQ20_09270	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEQ20_09275	COG0356	it plays a direct role in the translocation of protons across the membrane
HEQ20_09295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEQ20_09310	COG0765	amino acid transport
HEQ20_09325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEQ20_09375	COG2226	methyltransferase
HEQ20_09380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEQ20_09390	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ20_09395	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ20_09425	COG5002	protein histidine kinase activity
HEQ20_09460	COG0390	transport system, permease component
HEQ20_09480	COG2363	Small membrane protein
HEQ20_09485	COG2045	Belongs to the ComB family
HEQ20_09490	COG0793	Belongs to the peptidase S41A family
HEQ20_09525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEQ20_09530	COG3906	Belongs to the UPF0473 family
HEQ20_09535	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HEQ20_09540	COG2319	Wd-40 repeat
HEQ20_09550	COG0438	transferase activity, transferring glycosyl groups
HEQ20_09555	COG2988	succinylglutamate desuccinylase activity
HEQ20_09655	COG0438	transferase activity, transferring glycosyl groups
HEQ20_09660	COG1216	Glycosyl transferase, family 2
HEQ20_09675	COG1132	(ABC) transporter
HEQ20_09690	COG0489	protein tyrosine kinase activity
HEQ20_09725	COG1216	Glycosyl transferase, family 2
HEQ20_09730	COG1216	Glycosyl transferase, family 2
HEQ20_09735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEQ20_09740	COG0579	oxidoreductase
HEQ20_09765	COG4245	von Willebrand factor, type A
HEQ20_09770	COG0784	Response regulator, receiver
HEQ20_09845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEQ20_09850	COG1361	Conserved repeat domain
HEQ20_09865	COG0113	porphobilinogen synthase activity
HEQ20_09875	COG0735	belongs to the Fur family
HEQ20_09880	COG0678	peroxiredoxin activity
HEQ20_09915	COG0166	Belongs to the GPI family
HEQ20_09935	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_09940	COG1160	GTP binding
HEQ20_09960	COG5635	Nacht domain
HEQ20_09960	COG2319	Wd-40 repeat
HEQ20_10000	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HEQ20_10015	COG2208	phosphoserine phosphatase activity
HEQ20_10040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEQ20_10045	COG0805	protein transport
HEQ20_10060	COG2319	Wd-40 repeat
HEQ20_10060	COG1672	PFAM Archaeal ATPase
HEQ20_10090	COG3266	domain, Protein
HEQ20_10090	COG0515	serine threonine protein kinase
HEQ20_10105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEQ20_10125	COG1012	belongs to the aldehyde dehydrogenase family
HEQ20_10150	COG0584	glycerophosphoryl diester phosphodiesterase
HEQ20_10155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEQ20_10160	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEQ20_10165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEQ20_10170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEQ20_10210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEQ20_10290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEQ20_10300	COG0484	heat shock protein binding
HEQ20_10330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_10335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_10345	COG0450	alkyl hydroperoxide reductase
HEQ20_10365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEQ20_10365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEQ20_10385	COG0561	phosphatase activity
HEQ20_10395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEQ20_10420	COG0436	Aminotransferase
HEQ20_10425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEQ20_10430	COG0457	Tetratricopeptide repeat
HEQ20_10430	COG0463	Glycosyl transferase, family 2
HEQ20_10435	COG0322	excinuclease ABC activity
HEQ20_10440	COG0217	transcriptional regulatory protein
HEQ20_10470	COG0837	glucose binding
HEQ20_10480	COG0436	Aminotransferase
HEQ20_10485	COG0534	Mate efflux family protein
HEQ20_10500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEQ20_10505	COG1605	Chorismate mutase
HEQ20_10505	COG0077	Prephenate dehydratase
HEQ20_10520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEQ20_10520	COG0512	Glutamine amidotransferase of anthranilate synthase
HEQ20_10560	COG0525	valine-tRNA ligase activity
HEQ20_10575	COG0318	PFAM AMP-dependent synthetase and ligase
HEQ20_10585	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEQ20_10605	COG1487	ribonuclease activity
HEQ20_10610	COG1785	Belongs to the alkaline phosphatase family
HEQ20_10620	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEQ20_10640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_10655	COG0515	serine threonine protein kinase
HEQ20_10665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEQ20_10685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEQ20_10690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEQ20_10695	COG1104	cysteine desulfurase activity
HEQ20_10705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEQ20_10710	COG1234	tRNA 3'-trailer cleavage
HEQ20_10720	COG2197	response regulator
HEQ20_10775	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HEQ20_10780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_10795	COG0758	DNA mediated transformation
HEQ20_10795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEQ20_10815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEQ20_10830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEQ20_10835	COG0134	indole-3-glycerol-phosphate synthase activity
HEQ20_10860	COG0745	RESPONSE REGULATOR receiver
HEQ20_10890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ20_10895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEQ20_10955	COG0484	heat shock protein binding
HEQ20_10960	COG0740	serine-type endopeptidase activity
HEQ20_10965	COG0740	serine-type endopeptidase activity
HEQ20_10970	COG0740	serine-type endopeptidase activity
HEQ20_11020	COG0577	efflux transmembrane transporter activity
HEQ20_11020	COG1136	(ABC) transporter
HEQ20_11065	COG1122	ATPase activity
HEQ20_11070	COG0357	Ribosomal RNA small subunit methyltransferase G
HEQ20_11075	COG0196	riboflavin kinase activity
HEQ20_11090	COG0714	Associated with various cellular activities
HEQ20_11120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEQ20_11125	COG1408	metallophosphoesterase
HEQ20_11185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEQ20_11225	COG0003	Pfam Anion-transporting ATPase
HEQ20_11295	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_11330	COG1429	ligase activity, forming nitrogen-metal bonds
HEQ20_11375	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_11385	COG3093	addiction module antidote protein HigA
HEQ20_11470	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_11530	COG0745	RESPONSE REGULATOR receiver
HEQ20_11565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ20_11590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ20_11595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEQ20_11600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEQ20_11605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEQ20_11615	COG0438	transferase activity, transferring glycosyl groups
HEQ20_11620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEQ20_11635	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HEQ20_11640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEQ20_11645	COG0742	ribosomal rna small subunit methyltransferase
HEQ20_11655	COG2010	Cytochrome c
HEQ20_11665	COG0653	protein targeting
HEQ20_11685	COG0346	lactoylglutathione lyase activity
HEQ20_11690	COG0542	response to heat
HEQ20_11730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEQ20_11760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ20_11775	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ20_11780	COG2755	lipolytic protein G-D-S-L family
HEQ20_11780	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEQ20_11790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEQ20_11790	COG0426	domain, Protein
HEQ20_11795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEQ20_11795	COG0426	domain, Protein
HEQ20_11805	COG4399	Belongs to the UPF0754 family
HEQ20_11810	COG2226	methyltransferase
HEQ20_11825	COG2815	serine threonine protein kinase
HEQ20_11825	COG0515	serine threonine protein kinase
HEQ20_11830	COG2815	serine threonine protein kinase
HEQ20_11830	COG0515	serine threonine protein kinase
HEQ20_11840	COG0210	DNA helicase
HEQ20_11850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEQ20_11870	COG4636	protein conserved in cyanobacteria
HEQ20_11875	COG0126	phosphoglycerate kinase activity
HEQ20_11880	COG0589	response to stress
HEQ20_11955	COG3240	lipase activity
HEQ20_12135	COG0501	Belongs to the peptidase M48B family
HEQ20_12145	COG1722	exodeoxyribonuclease VII activity
HEQ20_12170	COG0561	phosphatase activity
HEQ20_12175	COG0632	four-way junction helicase activity
HEQ20_12180	COG0156	8-amino-7-oxononanoate synthase activity
HEQ20_12200	COG1570	exodeoxyribonuclease VII activity
HEQ20_12210	COG4221	oxidoreductase activity
HEQ20_12215	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HEQ20_12270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ20_12275	COG0277	FAD linked oxidase domain protein
HEQ20_12280	COG4251	negative regulation of phosphorylation
HEQ20_12280	COG4251	negative regulation of phosphorylation
HEQ20_12300	COG0215	cysteine-tRNA ligase activity
HEQ20_12320	COG0297	glycogen (starch) synthase activity
HEQ20_12330	COG0181	hydroxymethylbilane synthase activity
HEQ20_12345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEQ20_12375	COG0793	Belongs to the peptidase S41A family
HEQ20_12390	COG2046	Belongs to the sulfate adenylyltransferase family
HEQ20_12430	COG2337	Toxic component of a toxin-antitoxin (TA) module
HEQ20_12435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEQ20_12450	COG0848	biopolymer transport protein
HEQ20_12455	COG0811	peptide transport
HEQ20_12475	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HEQ20_12510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEQ20_12515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEQ20_12520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEQ20_12540	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HEQ20_12545	COG2255	four-way junction helicase activity
HEQ20_12555	COG0586	Pfam SNARE associated Golgi protein
HEQ20_12560	COG0137	argininosuccinate synthase activity
HEQ20_12565	COG1216	Glycosyl transferase, family 2
HEQ20_12575	COG0193	aminoacyl-tRNA hydrolase activity
HEQ20_12580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEQ20_12595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HEQ20_12685	COG0107	imidazoleglycerol-phosphate synthase activity
HEQ20_12705	COG0745	RESPONSE REGULATOR receiver
HEQ20_12710	COG1366	Belongs to the anti-sigma-factor antagonist family
HEQ20_12720	COG2385	sporulation resulting in formation of a cellular spore
HEQ20_12725	COG0633	Ferredoxin
HEQ20_12805	COG0673	inositol 2-dehydrogenase activity
HEQ20_12810	COG0024	Methionine aminopeptidase
HEQ20_12850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEQ20_12870	COG1937	Protein conserved in bacteria
HEQ20_12875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_12905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HEQ20_12915	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HEQ20_13000	COG1429	ligase activity, forming nitrogen-metal bonds
HEQ20_13035	COG0339	signal peptide processing
HEQ20_13070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEQ20_13085	COG3206	protein involved in exopolysaccharide biosynthesis
HEQ20_13085	COG0489	protein tyrosine kinase activity
HEQ20_13110	COG0367	asparagine synthase
HEQ20_13130	COG0438	transferase activity, transferring glycosyl groups
HEQ20_13240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEQ20_13250	COG1121	(ABC) transporter
HEQ20_13255	COG0803	Belongs to the bacterial solute-binding protein 9 family
HEQ20_13265	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HEQ20_13285	COG0438	transferase activity, transferring glycosyl groups
HEQ20_13295	COG0501	Belongs to the peptidase M48B family
HEQ20_13300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEQ20_13305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEQ20_13325	COG1910	domain protein
HEQ20_13340	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEQ20_13350	COG3659	wide pore channel activity
HEQ20_13365	COG2205	protein histidine kinase activity
HEQ20_13370	COG0589	response to stress
HEQ20_13395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_13405	COG3259	Nickel-dependent hydrogenase
HEQ20_13480	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HEQ20_13485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEQ20_13490	COG5002	protein histidine kinase activity
HEQ20_13500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEQ20_13540	COG0237	dephospho-CoA kinase activity
HEQ20_13545	COG1587	Uroporphyrinogen-III synthase
HEQ20_13550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEQ20_13555	COG0745	RESPONSE REGULATOR receiver
HEQ20_13585	COG1716	ATPase activity
HEQ20_13585	COG1131	(ABC) transporter
HEQ20_13585	COG0842	Transport permease protein
HEQ20_13610	COG2198	Histidine kinase
HEQ20_13610	COG0643	Histidine kinase
HEQ20_13615	COG2203	Gaf domain
HEQ20_13615	COG0840	transmembrane signaling receptor activity
HEQ20_13635	COG2201	protein-glutamate methylesterase activity
HEQ20_13640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEQ20_13685	COG3781	membrane
HEQ20_13690	COG1234	tRNA 3'-trailer cleavage
HEQ20_13700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEQ20_13705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEQ20_13720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEQ20_13725	COG0772	Belongs to the SEDS family
HEQ20_13800	COG0148	phosphopyruvate hydratase activity
HEQ20_13810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEQ20_13830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEQ20_13830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEQ20_13870	COG0408	coproporphyrinogen oxidase activity
HEQ20_13895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEQ20_13900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HEQ20_13910	COG2084	Dehydrogenase
HEQ20_13915	COG0629	single-stranded DNA binding
HEQ20_13950	COG0564	pseudouridine synthase activity
HEQ20_13965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEQ20_14055	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HEQ20_14065	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HEQ20_14075	COG3437	response regulator, receiver
HEQ20_14075	COG4999	Histidine kinase
HEQ20_14075	COG3850	Histidine kinase
HEQ20_14075	COG2205	protein histidine kinase activity
HEQ20_14085	COG0481	GTPase activity
HEQ20_14090	COG0277	FAD linked oxidase domain protein
HEQ20_14095	COG0247	lactate metabolic process
HEQ20_14110	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_14110	COG0515	serine threonine protein kinase
HEQ20_14120	COG0572	uridine kinase
HEQ20_14125	COG2003	Belongs to the UPF0758 family
HEQ20_14130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HEQ20_14160	COG0517	IMP dehydrogenase activity
HEQ20_14160	COG0516	GMP reductase activity
HEQ20_14205	COG2234	aminopeptidase activity
HEQ20_14235	COG0438	transferase activity, transferring glycosyl groups
HEQ20_14250	COG2204	response regulator
HEQ20_14255	COG2197	response regulator
HEQ20_14280	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HEQ20_14290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEQ20_14360	COG4245	von Willebrand factor, type A
HEQ20_14385	COG0300	oxidoreductase activity
HEQ20_14385	COG3000	fatty acid hydroxylase
HEQ20_14395	COG1132	(ABC) transporter
HEQ20_14405	COG0488	(ABC) transporter
HEQ20_14420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEQ20_14435	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_14485	COG0495	leucyl-tRNA aminoacylation
HEQ20_14490	COG2124	cytochrome p450
HEQ20_14520	COG2267	carboxylic ester hydrolase activity
HEQ20_14530	COG4636	protein conserved in cyanobacteria
HEQ20_14570	COG4581	dead DEAH box helicase
HEQ20_14610	COG1160	GTP binding
HEQ20_14680	COG0157	Belongs to the NadC ModD family
HEQ20_14685	COG0436	Aminotransferase
HEQ20_14690	COG3118	belongs to the thioredoxin family
HEQ20_14695	COG1842	Phage shock protein A
HEQ20_14700	COG1842	Phage shock protein A
HEQ20_14720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HEQ20_14725	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HEQ20_14740	COG0515	serine threonine protein kinase
HEQ20_14795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEQ20_14805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEQ20_14845	COG2217	Heavy metal translocating P-type atpase
HEQ20_14855	COG1090	epimerase
HEQ20_14875	COG0583	DNA-binding transcription factor activity
HEQ20_14885	COG3118	belongs to the thioredoxin family
HEQ20_14890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEQ20_14895	COG1002	Type II restriction enzyme, methylase subunits
HEQ20_14900	COG0515	serine threonine protein kinase
HEQ20_14920	COG4451	ribulose bisphosphate carboxylase, small
HEQ20_14930	COG1850	ribulose-bisphosphate carboxylase activity
HEQ20_14955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEQ20_15015	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HEQ20_15020	COG0438	transferase activity, transferring glycosyl groups
HEQ20_15025	COG1177	transmembrane transport
HEQ20_15040	COG1160	GTP binding
HEQ20_15050	COG2912	Transglutaminase-like superfamily
HEQ20_15060	COG3046	protein related to deoxyribodipyrimidine photolyase
HEQ20_15075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEQ20_15080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEQ20_15115	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ20_15120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEQ20_15125	COG0459	protein refolding
HEQ20_15135	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEQ20_15140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEQ20_15145	COG0012	GTP binding
HEQ20_15165	COG3344	reverse transcriptase
HEQ20_15175	COG3344	reverse transcriptase
HEQ20_15205	COG0793	Belongs to the peptidase S41A family
HEQ20_15240	COG0850	regulation of cytokinetic process
HEQ20_15245	COG2894	cell division
HEQ20_15250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEQ20_15255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HEQ20_15290	COG3344	reverse transcriptase
HEQ20_15320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEQ20_15350	COG2385	sporulation resulting in formation of a cellular spore
HEQ20_15355	COG0489	protein tyrosine kinase activity
HEQ20_15385	COG1252	NADH dehydrogenase
HEQ20_15395	COG0284	orotidine-5'-phosphate decarboxylase activity
HEQ20_15395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEQ20_15400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEQ20_15405	COG1104	cysteine desulfurase activity
HEQ20_15480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEQ20_15495	COG3854	ATPases associated with a variety of cellular activities
HEQ20_15520	COG0681	Belongs to the peptidase S26 family
HEQ20_15525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEQ20_15530	COG0802	atpase or kinase
HEQ20_15540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEQ20_15545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HEQ20_15575	COG1175	transmembrane transport
HEQ20_15610	COG0708	Exodeoxyribonuclease III
HEQ20_15655	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEQ20_15665	COG2217	Heavy metal translocating P-type atpase
HEQ20_15670	COG0123	including yeast histone deacetylase and acetoin utilization protein
HEQ20_15700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEQ20_15705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HEQ20_15775	COG0583	DNA-binding transcription factor activity
HEQ20_15780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEQ20_15785	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ20_15790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEQ20_15800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEQ20_15800	COG4451	ribulose bisphosphate carboxylase, small
HEQ20_15805	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HEQ20_15810	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ20_15815	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEQ20_15820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEQ20_15830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_15870	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_15875	COG4115	mRNA cleavage
HEQ20_15880	COG2161	toxin-antitoxin pair type II binding
HEQ20_15940	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_16010	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEQ20_16035	COG0140	phosphoribosyl-ATP diphosphatase activity
HEQ20_16035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEQ20_16040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEQ20_16045	COG0515	serine threonine protein kinase
HEQ20_16045	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_16065	COG0037	tRNA processing
HEQ20_16105	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEQ20_16115	COG1070	Carbohydrate kinase
HEQ20_16145	COG0625	glutathione transferase activity
HEQ20_16155	COG1666	GTP binding
HEQ20_16180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEQ20_16275	COG0542	response to heat
HEQ20_16305	COG0529	Catalyzes the synthesis of activated sulfate
HEQ20_16325	COG2814	Major facilitator Superfamily
HEQ20_16340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEQ20_16345	COG0109	protoheme IX farnesyltransferase activity
HEQ20_16355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEQ20_16360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEQ20_16365	COG1845	cytochrome c oxidase, subunit III
HEQ20_16380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEQ20_16390	COG2197	response regulator
HEQ20_16410	COG3265	gluconokinase activity
HEQ20_16420	COG1489	DNA binding
HEQ20_16435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEQ20_16440	COG1981	membrane
HEQ20_16450	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HEQ20_16460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEQ20_16465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEQ20_16475	COG0717	Belongs to the dCTP deaminase family
HEQ20_16570	COG0436	Aminotransferase
HEQ20_16575	COG0371	Dehydrogenase
HEQ20_16610	COG0587	DNA-directed DNA polymerase activity
HEQ20_16635	COG0360	Binds together with S18 to 16S ribosomal RNA
HEQ20_16655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEQ20_16660	COG2890	protein-(glutamine-N5) methyltransferase activity
HEQ20_16670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEQ20_16680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_16685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_16690	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_16695	COG1773	rubredoxin
HEQ20_16700	COG4447	cellulose binding
HEQ20_16770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEQ20_16780	COG0189	ligase activity
HEQ20_16785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HEQ20_16795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEQ20_16795	COG0519	Catalyzes the synthesis of GMP from XMP
HEQ20_16800	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HEQ20_16820	COG1496	oxidoreductase activity
HEQ20_16825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HEQ20_16825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HEQ20_16835	COG0741	lytic transglycosylase activity
HEQ20_16835	COG1196	nuclear chromosome segregation
HEQ20_16835	COG0739	heme binding
HEQ20_16840	COG0307	riboflavin synthase, alpha
HEQ20_16850	COG0784	Response regulator, receiver
HEQ20_16850	COG2198	Histidine kinase
HEQ20_16850	COG5002	protein histidine kinase activity
HEQ20_16875	COG1480	7TM receptor with intracellular HD hydrolase
HEQ20_16890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEQ20_16900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEQ20_16900	COG1754	DNA topoisomerase type I activity
HEQ20_16965	COG2319	Wd-40 repeat
HEQ20_16965	COG3903	Transcriptional regulator
HEQ20_17015	COG1007	ATP synthesis coupled electron transport
HEQ20_17025	COG0745	RESPONSE REGULATOR receiver
HEQ20_17030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEQ20_17045	COG2198	Histidine kinase
HEQ20_17045	COG2198	Histidine kinase
HEQ20_17045	COG0643	Histidine kinase
HEQ20_17045	COG0643	Histidine kinase
HEQ20_17065	COG0784	Response regulator, receiver
HEQ20_17100	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEQ20_17105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEQ20_17110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEQ20_17115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HEQ20_17120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEQ20_17125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HEQ20_17130	COG0646	methionine synthase
HEQ20_17130	COG1410	methionine synthase
HEQ20_17145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEQ20_17160	COG1012	belongs to the aldehyde dehydrogenase family
HEQ20_17165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HEQ20_17195	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEQ20_17205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEQ20_17210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEQ20_17215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEQ20_17220	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEQ20_17225	COG0740	serine-type endopeptidase activity
HEQ20_17230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEQ20_17285	COG2188	Transcriptional regulator
HEQ20_17290	COG0412	Dienelactone hydrolase
HEQ20_17295	COG0539	negative regulation of cytoplasmic translation
HEQ20_17320	COG0529	Catalyzes the synthesis of activated sulfate
HEQ20_17350	COG1316	TRANSCRIPTIONal
HEQ20_17355	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_17360	COG0728	peptidoglycan biosynthetic process
HEQ20_17365	COG2239	Acts as a magnesium transporter
HEQ20_17370	COG0540	Belongs to the ATCase OTCase family
HEQ20_17395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEQ20_17395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEQ20_17400	COG0222	ribosome binding
HEQ20_17405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEQ20_17410	COG0081	regulation of translation
HEQ20_17415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEQ20_17420	COG0250	Participates in transcription elongation, termination and antitermination
HEQ20_17425	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEQ20_17435	COG0335	large ribosomal subunit rRNA binding
HEQ20_17440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEQ20_17465	COG2201	protein-glutamate methylesterase activity
HEQ20_17475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEQ20_17485	COG5002	protein histidine kinase activity
HEQ20_17500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEQ20_17520	COG2267	carboxylic ester hydrolase activity
HEQ20_17545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEQ20_17560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEQ20_17570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEQ20_17575	COG0052	Belongs to the universal ribosomal protein uS2 family
HEQ20_17585	COG0006	proline dipeptidase activity
HEQ20_17595	COG1131	(ABC) transporter
HEQ20_17610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEQ20_17620	COG0788	formyltetrahydrofolate deformylase activity
HEQ20_17630	COG3153	acetyltransferase
HEQ20_17640	COG0315	cyclic pyranopterin monophosphate synthase activity
HEQ20_17655	COG0463	Glycosyl transferase, family 2
HEQ20_17660	COG0791	NLP P60 protein
HEQ20_17685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEQ20_17690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEQ20_17690	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEQ20_17735	COG0514	ATP-dependent DNA helicase (RecQ)
HEQ20_17745	COG1022	Amp-dependent synthetase and ligase
HEQ20_17760	COG3118	belongs to the thioredoxin family
HEQ20_17770	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_17795	COG2234	aminopeptidase activity
HEQ20_17800	COG0443	Heat shock 70 kDa protein
HEQ20_17805	COG0484	heat shock protein binding
HEQ20_17840	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HEQ20_17850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEQ20_17855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEQ20_17955	COG0644	oxidoreductase
HEQ20_17975	COG0300	oxidoreductase activity
HEQ20_17980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEQ20_17980	COG3320	Male sterility
HEQ20_17985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEQ20_17985	COG2070	2-Nitropropane dioxygenase
HEQ20_18000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEQ20_18000	COG1028	Short-chain dehydrogenase reductase Sdr
HEQ20_18000	COG3321	synthase
HEQ20_18000	COG4221	oxidoreductase activity
HEQ20_18005	COG0604	alcohol dehydrogenase
HEQ20_18005	COG3321	synthase
HEQ20_18060	COG0552	protein localization to endoplasmic reticulum
HEQ20_18065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEQ20_18080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEQ20_18095	COG1120	ATPase activity
HEQ20_18100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEQ20_18155	COG1858	cytochrome C peroxidase
HEQ20_18185	COG1294	oxidase, subunit
HEQ20_18190	COG1271	oxidase subunit
HEQ20_18195	COG0310	cobalt ion transport
HEQ20_18200	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HEQ20_18210	COG1122	ATPase activity
HEQ20_18215	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HEQ20_18225	COG1271	oxidase subunit
HEQ20_18230	COG1294	oxidase, subunit
HEQ20_18235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEQ20_18265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEQ20_18305	COG2361	Protein of unknown function DUF86
HEQ20_18315	COG0018	arginyl-trna synthetase
HEQ20_18325	COG2211	Major facilitator Superfamily
HEQ20_18340	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HEQ20_18375	COG4956	integral membrane protein (PIN domain superfamily)
HEQ20_18380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEQ20_18410	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEQ20_18415	COG3977	Valine--pyruvate aminotransferase
HEQ20_18425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEQ20_18435	COG0443	Heat shock 70 kDa protein
HEQ20_18450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEQ20_18460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEQ20_18470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HEQ20_18475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEQ20_18480	COG1215	transferase activity, transferring glycosyl groups
HEQ20_18485	COG1216	Glycosyl transferase, family 2
HEQ20_18490	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEQ20_18495	COG0697	spore germination
HEQ20_18500	COG0314	molybdopterin synthase activity
HEQ20_18535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEQ20_18540	COG1136	(ABC) transporter
HEQ20_18540	COG0577	efflux transmembrane transporter activity
HEQ20_18565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEQ20_18580	COG0483	inositol monophosphate 1-phosphatase activity
HEQ20_18590	COG3659	wide pore channel activity
HEQ20_18595	COG1959	2 iron, 2 sulfur cluster binding
HEQ20_18600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEQ20_18605	COG0484	heat shock protein binding
HEQ20_18630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEQ20_18635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEQ20_18645	COG0557	exoribonuclease II activity
HEQ20_18705	COG0242	peptide deformylase activity
HEQ20_18725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HEQ20_18725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HEQ20_18750	COG0205	6-phosphofructokinase activity
HEQ20_18755	COG0167	dihydroorotate dehydrogenase activity
HEQ20_18760	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEQ20_18760	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEQ20_18760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEQ20_18760	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEQ20_18775	COG0438	transferase activity, transferring glycosyl groups
HEQ20_18790	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEQ20_18810	COG0316	Belongs to the HesB IscA family
HEQ20_18825	COG0443	Heat shock 70 kDa protein
HEQ20_18850	COG1597	lipid kinase activity
HEQ20_18855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEQ20_18875	COG1012	belongs to the aldehyde dehydrogenase family
HEQ20_18895	COG0515	serine threonine protein kinase
HEQ20_18895	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_19015	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEQ20_19020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEQ20_19025	COG3842	ATPase activity
HEQ20_19030	COG0768	penicillin binding
HEQ20_19050	COG0406	alpha-ribazole phosphatase activity
HEQ20_19055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEQ20_19070	COG0215	cysteine-tRNA ligase activity
HEQ20_19080	COG0602	queuosine metabolic process
HEQ20_19085	COG0720	synthase
HEQ20_19090	COG0666	response to abiotic stimulus
HEQ20_19140	COG4783	chaperone-mediated protein folding
HEQ20_19145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEQ20_19155	COG0617	tRNA 3'-terminal CCA addition
HEQ20_19175	COG1214	PFAM Peptidase M22, glycoprotease
HEQ20_19210	COG1472	Belongs to the glycosyl hydrolase 3 family
HEQ20_19215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEQ20_19220	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEQ20_19220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEQ20_19225	COG1562	ergosterol biosynthetic process
HEQ20_19260	COG0071	Belongs to the small heat shock protein (HSP20) family
HEQ20_19285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEQ20_19320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEQ20_19325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEQ20_19335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEQ20_19340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEQ20_19345	COG0321	lipoyl(octanoyl) transferase activity
HEQ20_19350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEQ20_19355	COG0501	Belongs to the peptidase M48B family
HEQ20_19365	COG0489	protein tyrosine kinase activity
HEQ20_19400	COG0463	Glycosyl transferase, family 2
HEQ20_19405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEQ20_19455	COG0438	transferase activity, transferring glycosyl groups
HEQ20_19465	COG0438	transferase activity, transferring glycosyl groups
HEQ20_19510	COG0463	Glycosyl transferase, family 2
HEQ20_19520	COG1696	Membrane protein involved in D-alanine export
HEQ20_19525	COG1216	Glycosyl transferase, family 2
HEQ20_19560	COG0438	transferase activity, transferring glycosyl groups
HEQ20_19815	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEQ20_19840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_19850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEQ20_19860	COG0038	chloride channel
HEQ20_19865	COG0312	modulator of DNA gyrase
HEQ20_19875	COG1573	uracil-dna glycosylase
HEQ20_19890	COG1546	Belongs to the CinA family
HEQ20_19890	COG1058	Belongs to the CinA family
HEQ20_19895	COG1032	radical SAM domain protein
HEQ20_19910	COG0180	Tryptophanyl-tRNA synthetase
HEQ20_19940	COG0515	serine threonine protein kinase
HEQ20_19940	COG2815	serine threonine protein kinase
HEQ20_19970	COG0124	histidyl-tRNA synthetase
HEQ20_19975	COG0737	Belongs to the 5'-nucleotidase family
HEQ20_19985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEQ20_19990	COG0573	inorganic phosphate transmembrane transporter activity
HEQ20_19995	COG0581	inorganic phosphate transmembrane transporter activity
HEQ20_20000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEQ20_20095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEQ20_20105	COG4636	protein conserved in cyanobacteria
HEQ20_20120	COG0724	RNA recognition motif
HEQ20_20135	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_20155	COG0083	homoserine kinase activity
HEQ20_20165	COG0515	serine threonine protein kinase
HEQ20_20165	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_20180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEQ20_20190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEQ20_20195	COG0512	Glutamine amidotransferase of anthranilate synthase
HEQ20_20200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEQ20_20210	COG0004	ammonium transporteR
HEQ20_20220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEQ20_20230	COG1748	Saccharopine dehydrogenase
HEQ20_20235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HEQ20_20240	COG0613	PHP domain protein
HEQ20_20250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEQ20_20255	COG0415	Belongs to the DNA photolyase family
HEQ20_20260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HEQ20_20265	COG0243	molybdopterin cofactor binding
HEQ20_20270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEQ20_20275	COG2223	nitrite transmembrane transporter activity
HEQ20_20285	COG0739	heme binding
HEQ20_20290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEQ20_20295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEQ20_20300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEQ20_20305	COG0713	ATP synthesis coupled electron transport
HEQ20_20310	COG0839	Belongs to the complex I subunit 6 family
HEQ20_20315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_20320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEQ20_20325	COG0372	Belongs to the citrate synthase family
HEQ20_20330	COG2062	phosphohistidine phosphatase, SixA
HEQ20_20350	COG1131	(ABC) transporter
HEQ20_20365	COG2203	Gaf domain
HEQ20_20365	COG0840	transmembrane signaling receptor activity
HEQ20_20370	COG2198	Histidine kinase
HEQ20_20370	COG0784	Response regulator, receiver
HEQ20_20370	COG0643	Histidine kinase
HEQ20_20385	COG0596	Alpha beta hydrolase
HEQ20_20390	COG3639	organic phosphonate transmembrane transporter activity
HEQ20_20395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HEQ20_20405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEQ20_20445	COG3903	Transcriptional regulator
HEQ20_20445	COG2319	Wd-40 repeat
HEQ20_20460	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_20465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEQ20_20470	COG0509	glycine decarboxylation via glycine cleavage system
HEQ20_20485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEQ20_20490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEQ20_20520	COG4279	zinc finger
HEQ20_20545	COG0659	secondary active sulfate transmembrane transporter activity
HEQ20_20565	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_20595	COG0719	Fe-S assembly protein
HEQ20_20600	COG0396	ATPase activity
HEQ20_20605	COG0719	Fe-S assembly protein
HEQ20_20610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEQ20_20615	COG0454	-acetyltransferase
HEQ20_20620	COG5002	protein histidine kinase activity
HEQ20_20725	COG0814	amino acid
HEQ20_20760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEQ20_20760	COG0515	serine threonine protein kinase
HEQ20_20800	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HEQ20_20825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEQ20_20850	COG3429	Glucose-6-phosphate dehydrogenase subunit
HEQ20_20850	COG3409	Peptidoglycan-binding domain 1 protein
HEQ20_20855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEQ20_20860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HEQ20_20865	COG0745	RESPONSE REGULATOR receiver
HEQ20_20875	COG5002	protein histidine kinase activity
HEQ20_20875	COG0784	Response regulator, receiver
HEQ20_20905	COG0395	ABC-type sugar transport system, permease component
HEQ20_20925	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HEQ20_20945	COG0515	serine threonine protein kinase
HEQ20_20955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEQ20_20970	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_20975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ20_20980	COG1492	cobalamin metabolic process
HEQ20_20990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEQ20_21005	COG1253	flavin adenine dinucleotide binding
HEQ20_21030	COG3237	CsbD-like
HEQ20_21045	COG3237	CsbD-like
HEQ20_21050	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HEQ20_21060	COG1132	(ABC) transporter
HEQ20_21075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEQ20_21110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEQ20_21155	COG1193	negative regulation of DNA recombination
HEQ20_21170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HEQ20_21205	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HEQ20_21215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEQ20_21225	COG2154	pterin-4-alpha-carbinolamine dehydratase
HEQ20_21235	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HEQ20_21240	COG0426	domain, Protein
HEQ20_21240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEQ20_21255	COG0426	domain, Protein
HEQ20_21255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEQ20_21260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEQ20_21300	COG0312	modulator of DNA gyrase
HEQ20_21315	COG0047	phosphoribosylformylglycinamidine synthase activity
HEQ20_21325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEQ20_21330	COG0735	belongs to the Fur family
HEQ20_21335	COG0330	HflC and HflK could
HEQ20_21355	COG2091	lysine biosynthetic process via aminoadipic acid
HEQ20_21360	COG0429	hydrolase of the alpha beta-hydrolase fold
HEQ20_21365	COG0745	RESPONSE REGULATOR receiver
HEQ20_21375	COG1160	GTP binding
HEQ20_21380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEQ20_21435	COG2076	Multidrug Resistance protein
HEQ20_21440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEQ20_21480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEQ20_21485	COG4636	protein conserved in cyanobacteria
HEQ20_21570	COG1361	Conserved repeat domain
HEQ20_21600	COG0195	Participates in both transcription termination and antitermination
HEQ20_21605	COG0779	Required for maturation of 30S ribosomal subunits
HEQ20_21620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HEQ20_21645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEQ20_21685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEQ20_21690	COG0051	transcription antitermination factor activity, RNA binding
HEQ20_21700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEQ20_21705	COG0049	tRNA binding
HEQ20_21710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEQ20_21720	COG0316	Belongs to the HesB IscA family
HEQ20_21735	COG0069	glutamate synthase activity
HEQ20_21735	COG0070	glutamate synthase
HEQ20_21735	COG0067	glutamate synthase
HEQ20_21740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEQ20_21770	COG1487	ribonuclease activity
HEQ20_21785	COG2076	Multidrug Resistance protein
HEQ20_21790	COG0463	Glycosyl transferase, family 2
HEQ20_21800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEQ20_21815	COG0586	Pfam SNARE associated Golgi protein
HEQ20_21820	COG1132	(ABC) transporter
HEQ20_21870	COG3903	Transcriptional regulator
HEQ20_21870	COG2319	Wd-40 repeat
HEQ20_21885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEQ20_21890	COG0254	rRNA binding
HEQ20_21895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HEQ20_21900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEQ20_21905	COG0101	tRNA pseudouridine synthase activity
HEQ20_21910	COG0203	ribosomal protein L17
HEQ20_21915	COG0202	RNA polymerase activity
HEQ20_21920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEQ20_21925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEQ20_21930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HEQ20_21935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEQ20_21940	COG0563	adenylate kinase activity
HEQ20_21945	COG0201	protein transport
HEQ20_21950	COG0200	Binds to the 23S rRNA
HEQ20_21955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEQ20_21960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEQ20_21965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEQ20_21970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEQ20_21975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEQ20_21980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEQ20_21985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEQ20_21990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEQ20_21995	COG0255	Belongs to the universal ribosomal protein uL29 family
HEQ20_22000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEQ20_22005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEQ20_22010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEQ20_22015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEQ20_22020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEQ20_22025	COG0089	rRNA binding
HEQ20_22030	COG0088	Forms part of the polypeptide exit tunnel
HEQ20_22035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HEQ20_22070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEQ20_22085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEQ20_22095	COG0517	IMP dehydrogenase activity
HEQ20_22095	COG0617	tRNA 3'-terminal CCA addition
HEQ20_22095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HEQ20_22100	COG4636	protein conserved in cyanobacteria
HEQ20_22130	COG3937	granule-associated protein
HEQ20_22135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEQ20_22140	COG0631	protein serine/threonine phosphatase activity
HEQ20_22145	COG4644	lycopene metabolic process
HEQ20_22150	COG4974	Belongs to the 'phage' integrase family
HEQ20_22170	COG0515	serine threonine protein kinase
HEQ20_22180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEQ20_22185	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEQ20_22200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEQ20_22210	COG0592	DNA-directed DNA polymerase activity
HEQ20_22215	COG2010	Cytochrome c
HEQ20_22230	COG1136	(ABC) transporter
HEQ20_22240	COG0038	chloride channel
HEQ20_22250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEQ20_22265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEQ20_22265	COG3320	Male sterility
HEQ20_22295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEQ20_22315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEQ20_22325	COG0318	PFAM AMP-dependent synthetase and ligase
HEQ20_22325	COG0204	Acyl-transferase
HEQ20_22330	COG0529	Catalyzes the synthesis of activated sulfate
HEQ20_22345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEQ20_22350	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HEQ20_22360	COG0473	3-isopropylmalate dehydrogenase activity
HEQ20_22365	COG1872	DUF167
HEQ20_22375	COG1473	amidohydrolase
HEQ20_22415	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_22425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEQ20_22445	COG0686	Belongs to the AlaDH PNT family
HEQ20_22450	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HEQ20_22455	COG1127	ABC transporter
HEQ20_22470	COG0542	response to heat
HEQ20_22485	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_22485	COG0515	serine threonine protein kinase
HEQ20_22505	COG1834	amidinotransferase
HEQ20_22540	COG0450	alkyl hydroperoxide reductase
HEQ20_22545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEQ20_22550	COG5398	heme oxygenase
HEQ20_22560	COG1230	cation diffusion facilitator family transporter
HEQ20_22565	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEQ20_22595	COG2205	protein histidine kinase activity
HEQ20_22610	COG1230	cation diffusion facilitator family transporter
HEQ20_22645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEQ20_22650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HEQ20_22665	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEQ20_22680	COG0463	Glycosyl transferase, family 2
HEQ20_22730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEQ20_22755	COG0009	L-threonylcarbamoyladenylate synthase
HEQ20_22760	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HEQ20_22790	COG0312	modulator of DNA gyrase
HEQ20_22795	COG0312	modulator of DNA gyrase
HEQ20_22805	COG1196	nuclear chromosome segregation
HEQ20_22815	COG2183	response to ionizing radiation
HEQ20_22865	COG1950	PFAM Membrane protein of
HEQ20_22885	COG2010	Cytochrome c
HEQ20_22935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEQ20_22940	COG0784	Response regulator, receiver
HEQ20_22945	COG0564	pseudouridine synthase activity
HEQ20_22960	COG0237	dephospho-CoA kinase activity
HEQ20_22970	COG1413	lyase activity
HEQ20_22980	COG1413	lyase activity
HEQ20_22985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEQ20_22990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEQ20_22995	COG0237	dephospho-CoA kinase activity
HEQ20_23000	COG0237	dephospho-CoA kinase activity
HEQ20_23020	COG0121	glutamine amidotransferase
HEQ20_23030	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEQ20_23035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEQ20_23040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEQ20_23045	COG4208	sulfate ABC transporter
HEQ20_23095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HEQ20_23105	COG2337	Toxic component of a toxin-antitoxin (TA) module
HEQ20_23130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HEQ20_23145	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HEQ20_23200	COG0824	Thioesterase
HEQ20_23205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEQ20_23225	COG0416	fatty acid biosynthetic process
HEQ20_23230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEQ20_23235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEQ20_23255	COG2010	Cytochrome c
HEQ20_23260	COG0456	acetyltransferase
HEQ20_23265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ20_23270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEQ20_23275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEQ20_23330	COG0529	Catalyzes the synthesis of activated sulfate
HEQ20_23380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HEQ20_23400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEQ20_23410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HEQ20_23430	COG0629	single-stranded DNA binding
HEQ20_23435	COG1077	Cell shape determining protein MreB Mrl
HEQ20_23455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEQ20_23470	COG0475	glutathione-regulated potassium exporter activity
HEQ20_23475	COG2247	cell wall binding repeat
HEQ20_23475	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEQ20_23480	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEQ20_23485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HEQ20_23495	COG0142	geranyltranstransferase activity
HEQ20_23530	COG2052	Domain of unknown function (DUF370)
HEQ20_23535	COG0194	GDP metabolic process
HEQ20_23560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEQ20_23565	COG2267	carboxylic ester hydrolase activity
HEQ20_23575	COG0454	-acetyltransferase
HEQ20_23585	COG0824	Thioesterase
HEQ20_23590	COG0318	PFAM AMP-dependent synthetase and ligase
HEQ20_23600	COG1575	Belongs to the MenA family. Type 1 subfamily
HEQ20_23610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEQ20_23705	COG0003	Pfam Anion-transporting ATPase
HEQ20_23710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ20_23770	COG1653	transport
HEQ20_23775	COG1175	transmembrane transport
HEQ20_23790	COG3956	TIGRFAM MazG family protein
HEQ20_23810	COG4636	protein conserved in cyanobacteria
HEQ20_23820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEQ20_23830	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEQ20_23835	COG0546	phosphoglycolate phosphatase activity
HEQ20_23840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEQ20_23855	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HEQ20_23865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEQ20_23870	COG2226	methyltransferase
HEQ20_23875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HEQ20_23880	COG0569	domain protein
HEQ20_23890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEQ20_23900	COG0792	nuclease activity
HEQ20_23920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEQ20_23925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEQ20_23940	COG3118	belongs to the thioredoxin family
HEQ20_23950	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_23995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEQ20_24020	COG0642	Histidine kinase
HEQ20_24020	COG3850	Histidine kinase
HEQ20_24030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEQ20_24035	COG0751	glycine-tRNA ligase activity
HEQ20_24040	COG4968	Prepilin-type N-terminal cleavage methylation domain
HEQ20_24045	COG4968	Prepilin-type N-terminal cleavage methylation domain
HEQ20_24105	COG1196	nuclear chromosome segregation
HEQ20_24195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ20_24210	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HEQ20_24230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEQ20_24325	COG3609	addiction module antidote protein, CC2985 family
HEQ20_24355	COG2337	Toxic component of a toxin-antitoxin (TA) module
HEQ20_24360	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HEQ20_24410	COG2124	cytochrome p450
HEQ20_24445	COG0149	triose-phosphate isomerase activity
HEQ20_24450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEQ20_24455	COG0330	HflC and HflK could
HEQ20_24460	COG1596	polysaccharide export
HEQ20_24465	COG1131	(ABC) transporter
HEQ20_24470	COG0131	Imidazoleglycerol-phosphate dehydratase
HEQ20_24480	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEQ20_24485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEQ20_24490	COG4372	Transposase
HEQ20_24535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ20_24540	COG0187	DNA topoisomerase II activity
HEQ20_24540	COG1372	Participates in initiation and elongation during chromosome replication
HEQ20_24545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEQ20_24550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEQ20_24580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEQ20_24590	COG0284	orotidine-5'-phosphate decarboxylase activity
HEQ20_24605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEQ20_24630	COG0681	Belongs to the peptidase S26 family
HEQ20_24640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEQ20_24685	COG0539	negative regulation of cytoplasmic translation
HEQ20_24695	COG0778	Nitroreductase
HEQ20_24710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEQ20_24715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEQ20_24720	COG1845	cytochrome c oxidase, subunit III
HEQ20_24735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEQ20_24750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEQ20_24755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEQ20_24800	COG1487	ribonuclease activity
HEQ20_24815	COG3609	addiction module antidote protein, CC2985 family
HEQ20_24895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HEQ20_24900	COG0594	ribonuclease P activity
HEQ20_24910	COG0706	membrane insertase activity
HEQ20_24925	COG4680	protein conserved in bacteria
HEQ20_24935	COG1185	polyribonucleotide nucleotidyltransferase activity
HEQ20_24945	COG0165	Argininosuccinate lyase
HEQ20_24955	COG1691	(AIR) carboxylase
HEQ20_24975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEQ20_24985	COG4242	Belongs to the peptidase S51 family
HEQ20_24990	COG0189	ligase activity
HEQ20_24990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEQ20_24995	COG1487	ribonuclease activity
HEQ20_25030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HEQ20_25050	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HEQ20_25055	COG1253	flavin adenine dinucleotide binding
HEQ20_25060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEQ20_25080	COG0259	pyridoxamine-phosphate oxidase activity
HEQ20_25085	COG0628	permease
HEQ20_25095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEQ20_25100	COG1166	arginine decarboxylase activity
HEQ20_25105	COG0105	UTP biosynthetic process
HEQ20_25110	COG0861	Integral membrane protein TerC family
HEQ20_25130	COG0745	RESPONSE REGULATOR receiver
HEQ20_25145	COG0419	ATPase involved in DNA repair
HEQ20_25170	COG0445	tRNA wobble uridine modification
HEQ20_25185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEQ20_25195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEQ20_25200	COG1266	CAAX protease self-immunity
HEQ20_25220	COG3903	Transcriptional regulator
HEQ20_25220	COG2319	Wd-40 repeat
HEQ20_25235	COG0673	inositol 2-dehydrogenase activity
HEQ20_25245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEQ20_25260	COG2226	methyltransferase
HEQ20_25270	COG0306	phosphate transporter
HEQ20_25275	COG0697	spore germination
HEQ20_25290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEQ20_25295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEQ20_25310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEQ20_25365	COG0129	dihydroxy-acid dehydratase activity
HEQ20_25375	COG2076	Multidrug Resistance protein
HEQ20_25380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEQ20_25380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEQ20_25395	COG1073	alpha beta
HEQ20_25395	COG2226	methyltransferase
HEQ20_25405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEQ20_25410	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HEQ20_25420	COG0505	Belongs to the CarA family
HEQ20_25450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEQ20_25530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEQ20_25550	COG1530	ribonuclease E activity
HEQ20_25555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEQ20_25565	COG0077	Prephenate dehydratase
HEQ20_25565	COG1605	Chorismate mutase
HEQ20_25585	COG0577	efflux transmembrane transporter activity
HEQ20_25585	COG1136	(ABC) transporter
HEQ20_25605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEQ20_25620	COG0395	ABC-type sugar transport system, permease component
HEQ20_25635	COG2304	oxidoreductase activity
HEQ20_25650	COG0612	Peptidase, M16
HEQ20_25660	COG0748	coenzyme F420 binding
HEQ20_25675	COG0351	phosphomethylpyrimidine kinase
HEQ20_25685	COG0649	NAD binding
HEQ20_25715	COG0275	rRNA processing
HEQ20_25765	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HEQ20_25770	COG4251	negative regulation of phosphorylation
HEQ20_25780	COG2205	protein histidine kinase activity
HEQ20_25785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEQ20_25815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HEQ20_25835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEQ20_25840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEQ20_25885	COG1487	ribonuclease activity
HEQ20_25895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEQ20_25905	COG2066	Belongs to the glutaminase family
HEQ20_25915	COG2885	chlorophyll binding
HEQ20_25935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_26005	COG0439	Biotin carboxylase
HEQ20_26020	COG0515	serine threonine protein kinase
HEQ20_26035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEQ20_26040	COG0457	Tetratricopeptide repeat
HEQ20_26115	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HEQ20_26130	COG0714	Associated with various cellular activities
HEQ20_26175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEQ20_26175	COG0475	glutathione-regulated potassium exporter activity
HEQ20_26180	COG0151	Belongs to the GarS family
HEQ20_26235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEQ20_26300	COG3394	polysaccharide catabolic process
HEQ20_26315	COG3344	reverse transcriptase
HEQ20_26345	COG1982	Orn Lys Arg decarboxylase major
HEQ20_26350	COG1006	Multisubunit Na H antiporter MnhC subunit
HEQ20_26395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEQ20_26405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEQ20_26410	COG0750	zinc metalloprotease
HEQ20_26420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEQ20_26430	COG1940	carbohydrate kinase activity
HEQ20_26435	COG0504	CTP synthase activity
HEQ20_26440	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEQ20_26460	COG0826	peptidase U32
HEQ20_26465	COG4771	TonB-dependent receptor
HEQ20_26480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEQ20_26485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEQ20_26495	COG1116	anion transmembrane transporter activity
HEQ20_26500	COG1116	anion transmembrane transporter activity
HEQ20_26500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_26505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEQ20_26510	COG0571	ribonuclease III activity
HEQ20_26530	COG0515	serine threonine protein kinase
HEQ20_26535	COG0538	isocitrate dehydrogenase activity
HEQ20_26555	COG2267	carboxylic ester hydrolase activity
HEQ20_26565	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEQ20_26590	COG1054	Belongs to the UPF0176 family
HEQ20_26595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEQ20_26595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEQ20_26605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEQ20_26680	COG0723	plastoquinol--plastocyanin reductase activity
HEQ20_26685	COG3258	Cytochrome c
HEQ20_26690	COG0303	'Molybdopterin
HEQ20_26700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEQ20_26710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEQ20_26725	COG0513	Belongs to the DEAD box helicase family
HEQ20_26735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HEQ20_26740	COG1381	Involved in DNA repair and RecF pathway recombination
HEQ20_26750	COG0438	transferase activity, transferring glycosyl groups
HEQ20_26765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEQ20_26790	COG0406	alpha-ribazole phosphatase activity
HEQ20_26800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HEQ20_26810	COG0752	glycyl-tRNA synthetase alpha subunit
HEQ20_26845	COG1657	PFAM Prenyltransferase squalene oxidase
HEQ20_26885	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HEQ20_26890	COG0830	nickel cation binding
HEQ20_26895	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEQ20_26915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEQ20_26925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEQ20_26930	COG0798	PFAM Bile acid sodium symporter
HEQ20_26940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEQ20_26980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HEQ20_26995	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEQ20_27000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEQ20_27010	COG0701	Predicted permease
HEQ20_27045	COG1053	succinate dehydrogenase
HEQ20_27055	COG2211	Major facilitator Superfamily
HEQ20_27060	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HEQ20_27065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEQ20_27070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEQ20_27085	COG1217	gtp-binding protein TYPA
HEQ20_27115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEQ20_27120	COG3064	Membrane
HEQ20_27120	COG0515	serine threonine protein kinase
HEQ20_27120	COG4991	sh3 domain protein
HEQ20_27125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEQ20_27130	COG1473	amidohydrolase
HEQ20_27135	COG0154	amidase activity
HEQ20_27150	COG2815	serine threonine protein kinase
HEQ20_27150	COG0515	serine threonine protein kinase
HEQ20_27195	COG0587	DNA-directed DNA polymerase activity
HEQ20_27205	COG1943	Transposase
HEQ20_27235	COG1088	dTDP-glucose 4,6-dehydratase activity
HEQ20_27240	COG0134	indole-3-glycerol-phosphate synthase activity
HEQ20_27250	COG0745	RESPONSE REGULATOR receiver
HEQ20_27265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEQ20_27270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEQ20_27285	COG0515	serine threonine protein kinase
HEQ20_27285	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_27320	COG0515	serine threonine protein kinase
HEQ20_27320	COG3266	domain, Protein
HEQ20_27330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HEQ20_27340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEQ20_27355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEQ20_27355	COG0438	transferase activity, transferring glycosyl groups
HEQ20_27370	COG1316	TRANSCRIPTIONal
HEQ20_27380	COG0628	permease
HEQ20_27400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEQ20_27405	COG0515	serine threonine protein kinase
HEQ20_27405	COG1357	PFAM Pentapeptide repeats (8 copies)
HEQ20_27415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEQ20_27440	COG3536	Protein conserved in bacteria
HEQ20_27460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEQ20_27510	COG5002	protein histidine kinase activity
HEQ20_27520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEQ20_27545	COG0095	Lipoate-protein ligase
HEQ20_27565	COG1192	Involved in chromosome partitioning
HEQ20_27570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEQ20_27575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HEQ20_27575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEQ20_27580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEQ20_27585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEQ20_27590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEQ20_27595	COG1304	FMN binding
HEQ20_27600	COG0616	signal peptide processing
HEQ20_27640	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HEQ20_27640	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HEQ20_27665	COG0004	ammonium transporteR
HEQ20_27680	COG0612	Peptidase, M16
HEQ20_27685	COG0612	Peptidase, M16
HEQ20_27700	COG0384	phenazine biosynthesis protein PhzF
HEQ20_27730	COG1136	(ABC) transporter
HEQ20_27740	COG0436	Aminotransferase
HEQ20_27755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEQ20_27780	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_27785	COG4935	Belongs to the peptidase S8 family
HEQ20_27785	COG1404	Belongs to the peptidase S8 family
HEQ20_27800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HEQ20_27805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEQ20_27810	COG4597	amino acid ABC transporter
HEQ20_27815	COG0765	amino acid transport
HEQ20_27820	COG1126	abc transporter atp-binding protein
HEQ20_27850	COG0494	nUDIX hydrolase
HEQ20_27860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ20_27865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEQ20_27870	COG0783	Belongs to the Dps family
HEQ20_27895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEQ20_27900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEQ20_27905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HEQ20_27905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEQ20_27915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEQ20_27935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEQ20_28010	COG0515	serine threonine protein kinase
HEQ20_28010	COG3266	domain, Protein
HEQ20_28020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEQ20_28025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEQ20_28040	COG0573	inorganic phosphate transmembrane transporter activity
HEQ20_28045	COG0581	inorganic phosphate transmembrane transporter activity
HEQ20_28050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEQ20_28055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEQ20_28065	COG0523	cobalamin synthesis protein
HEQ20_28090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_28095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEQ20_28100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEQ20_28100	COG1116	anion transmembrane transporter activity
HEQ20_28105	COG1116	anion transmembrane transporter activity
HEQ20_28110	COG0243	molybdopterin cofactor binding
HEQ20_28190	COG0556	nucleotide-excision repair
HEQ20_28250	COG0419	ATPase involved in DNA repair
HEQ20_28265	COG2814	Major facilitator Superfamily
HEQ20_28305	COG1968	undecaprenyl-diphosphatase activity
HEQ20_28315	COG1555	photosystem II stabilization
HEQ20_28320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEQ20_28325	COG4243	Vitamin k epoxide reductase
HEQ20_28330	COG0434	BtpA family
HEQ20_28335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEQ20_28340	COG0513	Belongs to the DEAD box helicase family
HEQ20_28445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEQ20_28450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEQ20_28455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEQ20_28460	COG0735	belongs to the Fur family
HEQ20_28465	COG3773	Cell wall hydrolase
HEQ20_28465	COG3409	Peptidoglycan-binding domain 1 protein
HEQ20_28495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEQ20_28505	COG0857	belongs to the CobB CobQ family
HEQ20_28555	COG0514	ATP-dependent DNA helicase (RecQ)
HEQ20_28590	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_28610	COG1215	transferase activity, transferring glycosyl groups
HEQ20_28640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEQ20_28640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEQ20_28640	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEQ20_28640	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEQ20_28660	COG0251	oxidation-reduction process
HEQ20_28690	COG1640	4-alpha-glucanotransferase
HEQ20_28700	COG1426	Protein conserved in bacteria
HEQ20_28705	COG1187	pseudouridine synthase activity
HEQ20_28715	COG0575	Belongs to the CDS family
HEQ20_28730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEQ20_28760	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_28770	COG1598	PFAM Uncharacterised protein family UPF0150
HEQ20_28780	COG4948	Mandelate Racemase Muconate Lactonizing
HEQ20_28790	COG0515	serine threonine protein kinase
HEQ20_28790	COG2815	serine threonine protein kinase
HEQ20_28800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HEQ20_28810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEQ20_28825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEQ20_28830	COG0745	RESPONSE REGULATOR receiver
HEQ20_28940	COG0515	serine threonine protein kinase
HEQ20_28940	COG2815	serine threonine protein kinase
HEQ20_28950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEQ20_28970	COG0006	proline dipeptidase activity
HEQ20_29010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEQ20_29015	COG0702	epimerase
HEQ20_29025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEQ20_29030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEQ20_29040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEQ20_29045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEQ20_29050	COG2048	Heterodisulfide reductase, subunit B
HEQ20_29055	COG0242	peptide deformylase activity
HEQ20_29070	COG1487	ribonuclease activity
HEQ20_29075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain