locus-tag	class	description
G8C43_00015	ENOG4107QPK	)-transporter
G8C43_00020	ENOG4105CZH	peptidase
G8C43_00025	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
G8C43_00030	ENOG4105CSR	polyphosphate kinase 2
G8C43_00035	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
G8C43_00040	ENOG4105C9A	Phoh family
G8C43_00045	ENOG4105CAT	Cytidine monophosphate kinase
G8C43_00060	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
G8C43_00070	ENOG4108IUX	(ABC) transporter
G8C43_00085	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
G8C43_00090	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
G8C43_00100	ENOG4105I3K	Ferric uptake regulator, Fur family
G8C43_00105	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
G8C43_00110	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
G8C43_00125	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
G8C43_00130	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
G8C43_00135	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
G8C43_00140	ENOG4105DTN	riboflavin biosynthesis protein ribF
G8C43_00150	ENOG4105SFS	phosphoesterase RecJ domain protein
G8C43_00165	ENOG4105E6M	Sulphatase-modifying factor protein
G8C43_00180	ENOG4107QI6	Cysteine desulfurase
G8C43_00185	ENOG4105CK2	sodium dicarboxylate symporter
G8C43_00190	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
G8C43_00195	ENOG4105C7N	Xanthine uracil vitamin C permease
G8C43_00200	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
G8C43_00205	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
G8C43_00210	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
G8C43_00220	ENOG4108RYK	Nad-dependent epimerase dehydratase
G8C43_00225	ENOG4105EN6	Membrane
G8C43_00235	ENOG4108YZG	isomerase
G8C43_00240	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
G8C43_00250	ENOG4105CBX	hi0933 family
G8C43_00270	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
G8C43_00275	ENOG4105ESV	Glycosyl transferase, family 4
G8C43_00315	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
G8C43_00320	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G8C43_00335	ENOG4105KME	endoribonuclease L-psp
G8C43_00350	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
G8C43_00360	ENOG4105CAQ	asparagine synthetase
G8C43_00365	ENOG4107RF4	Phosphodiesterase
G8C43_00370	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
G8C43_00380	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
G8C43_00390	ENOG4108HRK	Histidine kinase
G8C43_00395	ENOG4105DY9	regulatoR
G8C43_00430	ENOG4107QKV	phosphomannomutase
G8C43_00435	ENOG4107RN3	metallophosphoesterase
G8C43_00445	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
G8C43_00450	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
G8C43_00455	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
G8C43_00460	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
G8C43_00470	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
G8C43_00480	ENOG4105CPK	Glycosyl transferase (Group 1
G8C43_00485	ENOG4105D6E	homoserine dehydrogenase
G8C43_00490	ENOG4105C28	cystathionine
G8C43_00495	ENOG4105KV4	Transcriptional regulator
G8C43_00500	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
G8C43_00505	ENOG4105C8T	Leucyl-tRNA synthetase
G8C43_00580	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
G8C43_00590	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
G8C43_00595	ENOG4105CSA	Coproporphyrinogen iii oxidase
G8C43_00610	ENOG4105C4K	Nad synthetase
G8C43_00620	ENOG4108UT2	hemolysin iii
G8C43_00625	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
G8C43_00630	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
G8C43_00650	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
G8C43_00660	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
G8C43_00670	ENOG410847I	Transcriptional regulator, BadM Rrf2 family
G8C43_00690	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
G8C43_00695	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
G8C43_00715	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
G8C43_00720	ENOG4105F4R	Transcriptional regulator mode
G8C43_00725	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
G8C43_00745	ENOG4108RPX	mosc domain containing protein
G8C43_00755	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
G8C43_00760	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
G8C43_00765	ENOG4105E0C	molybdate abc transporter
G8C43_00770	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
G8C43_00775	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
G8C43_00780	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
G8C43_00910	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
G8C43_00915	ENOG4105DUM	transcriptional regulator, lysR family
G8C43_00920	ENOG4105CAY	ferredoxin--nadp reductase
G8C43_00935	ENOG4108TZV	Membrane
G8C43_00940	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
G8C43_00945	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
G8C43_00960	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
G8C43_00975	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
G8C43_00985	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
G8C43_01010	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
G8C43_01025	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
G8C43_01040	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
G8C43_01045	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
G8C43_01250	ENOG4105EVB	acetyltransferase
G8C43_01295	ENOG4105D1F	ATP-binding protein
G8C43_01310	ENOG4107S52	alpha-2-macroglobulin domain protein
G8C43_01330	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
G8C43_01345	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
G8C43_01350	ENOG4105C5S	asparaginyl-tRNA synthetase
G8C43_01380	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
G8C43_01395	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
G8C43_01425	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
G8C43_01435	ENOG4106H78	methyltransferase
G8C43_01440	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
G8C43_01445	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
G8C43_01450	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
G8C43_01465	ENOG4107RAQ	aminopeptidase
G8C43_01515	ENOG4105CIN	aminoacyl-histidine dipeptidase
G8C43_01520	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
G8C43_01530	ENOG41090JD	Blue (Type 1) copper domain protein
G8C43_01540	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
G8C43_01545	ENOG4105C2X	Arabinose 5-phosphate isomerase
G8C43_01550	ENOG4105C9U	ATP-dependent DNA helicase RecQ
G8C43_01580	ENOG4105C10	Electron transfer flavoprotein
G8C43_01600	ENOG4105K64	Glycosyl transferase, family 2
G8C43_01645	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
G8C43_01650	ENOG4105C25	Primosomal protein n'
G8C43_01655	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
G8C43_01660	ENOG4108UJU	UPF0301 protein
G8C43_01670	ENOG4105CN9	Peptidase m42 family protein
G8C43_01680	ENOG4105CRE	cytochrome C
G8C43_01690	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
G8C43_01710	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
G8C43_01725	ENOG4108V0P	LemA family
G8C43_01760	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G8C43_01765	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
G8C43_01775	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
G8C43_01780	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
G8C43_01785	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
G8C43_01800	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
G8C43_01815	ENOG4107QN2	dihydrolipoyl dehydrogenase
G8C43_01820	ENOG4108Z03	MAF-like protein
G8C43_01830	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
G8C43_01835	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
G8C43_01845	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
G8C43_01850	ENOG4107SET	aldo keto reductase
G8C43_01875	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
G8C43_01885	ENOG4105EMN	RNA polymerase sigma factor
G8C43_01895	ENOG4105CJ1	ABC, transporter
G8C43_01900	ENOG4105CQC	Prephenate dehydratase
G8C43_01915	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
G8C43_01920	ENOG4105C2M	dna polymerase I
G8C43_01925	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
G8C43_01940	ENOG4105BZ1	(ABC) transporter
G8C43_01950	ENOG4107QJE	Chromosome Partitioning Protein
G8C43_01955	ENOG4105FA0	parb-like partition protein
G8C43_01970	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
G8C43_01975	ENOG4105C3F	Signal peptidase i
G8C43_01995	ENOG4107UNZ	domain protein
G8C43_02005	ENOG4105ENX	hydrolase
G8C43_02010	ENOG4108RCM	Nitroreductase
G8C43_02030	ENOG4105C85	amino acid
G8C43_02040	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
G8C43_02050	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
G8C43_02055	ENOG4105D1H	recombination factor protein RarA
G8C43_02070	ENOG4108IQE	Amp-dependent synthetase and ligase
G8C43_02080	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G8C43_02125	ENOG4105HDK	L-asparaginase
G8C43_02130	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
G8C43_02145	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
G8C43_02150	ENOG4105CP7	Triose-phosphate isomerase
G8C43_02170	ENOG4105EEI	dihydropteroate synthase
G8C43_02175	ENOG4105EAC	phosphoserine phosphatase
G8C43_02180	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
G8C43_02185	ENOG4108UHE	carbonic anhydrase
G8C43_02200	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
G8C43_02205	ENOG4105C3M	thioredoxin reductase
G8C43_02220	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
G8C43_02225	ENOG4105C3G	gtp-binding protein
G8C43_02235	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
G8C43_02240	ENOG4105C7K	acetolactate synthase
G8C43_02245	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
G8C43_02250	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
G8C43_02255	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
G8C43_02260	ENOG4105K63	Thioredoxin
G8C43_02275	ENOG4105CKK	Glycosyl transferase, family 2
G8C43_02295	ENOG4105D7W	serine acetyltransferase
G8C43_02305	ENOG4105EGD	dinuclear metal center protein, YbgI family
G8C43_02310	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
G8C43_02315	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
G8C43_02320	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
G8C43_02325	ENOG4105D49	3-dehydroquinate synthase
G8C43_02340	ENOG4105E33	succinate dehydrogenase
G8C43_02375	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
G8C43_02380	ENOG4105CPF	Cell wall formation (By similarity)
G8C43_02390	ENOG4105C34	Pseudouridine synthase
G8C43_02395	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
G8C43_02400	ENOG4105D4P	Coproporphyrinogen iii oxidase
G8C43_02415	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
G8C43_02420	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G8C43_02425	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G8C43_02430	ENOG4105C19	ABC transporter
G8C43_02435	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
G8C43_02445	ENOG41074B2	UPF0747 protein
G8C43_02490	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
G8C43_02495	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
G8C43_02510	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
G8C43_02515	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
G8C43_02520	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
G8C43_02525	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
G8C43_02530	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
G8C43_02535	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
G8C43_02540	ENOG4105DCI	Phosphohydrolase
G8C43_02545	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
G8C43_02565	ENOG4108JQ1	Dehydrogenase
G8C43_02570	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
G8C43_02575	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
G8C43_02585	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
G8C43_02610	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
G8C43_02615	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
G8C43_02620	ENOG4105DFU	Cell wall formation (By similarity)
G8C43_02635	ENOG4105C7S	Dehydrogenase
G8C43_02640	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
G8C43_02645	ENOG4107TE5	Lipid kinase
G8C43_02650	ENOG4105DJV	ribulose-phosphate 3-epimerase
G8C43_02665	ENOG4105CMR	udp-glucose 4-epimerase
G8C43_02675	ENOG4105K70	DNA-binding protein
G8C43_02695	ENOG4105CHM	Aminotransferase
G8C43_02700	ENOG4107R0I	Cell wall formation (By similarity)
G8C43_02705	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
G8C43_02760	ENOG4107QI1	Mate efflux family protein
G8C43_02775	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
G8C43_02785	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
G8C43_02790	ENOG410874W	AraC family transcriptional regulator
G8C43_02810	ENOG4105C0H	protease
G8C43_02815	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G8C43_02820	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
G8C43_02825	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
G8C43_02830	ENOG4108YV4	Universal stress protein
G8C43_02835	ENOG4105DZP	Membrane-associated zinc metalloprotease
G8C43_02840	ENOG4105CDV	Ompa motb domain protein
G8C43_02850	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
G8C43_02855	ENOG4108TJN	glycosyl transferase group 1
G8C43_02900	ENOG4105D75	Capsular exopolysaccharide family
G8C43_02915	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
G8C43_02920	ENOG4105CN1	protease
G8C43_02925	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
G8C43_02935	ENOG4105C87	Aminotransferase class I and II
G8C43_02940	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
G8C43_02945	ENOG4105E0A	ABC, transporter
G8C43_02955	ENOG4105CQB	FAD linked oxidase domain protein
G8C43_02970	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
G8C43_02980	ENOG4105DF5	DNA topoisomerase IV, subunit A
G8C43_02985	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
G8C43_03000	ENOG4105M2Z	protein tyrosine serine phosphatase
G8C43_03005	ENOG4105C59	p-type ATPase
G8C43_03010	ENOG4105KA0	thioesterase Superfamily protein
G8C43_03030	ENOG4105D05	Receptor
G8C43_03070	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
G8C43_03090	ENOG4105NVB	glycoside hydrolase, family 19
G8C43_03150	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
G8C43_03155	ENOG4105K5M	30s ribosomal protein S16
G8C43_03160	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
G8C43_03165	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
G8C43_03180	ENOG4105DHQ	Histidine kinase
G8C43_03185	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
G8C43_03195	ENOG4105CW7	secretion protein, HlyD family
G8C43_03210	ENOG4108QSZ	General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity)
G8C43_03220	ENOG4105CPP	Dehydrogenase, E1 component
G8C43_03225	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
G8C43_03235	ENOG4105CD8	aminopeptidase N
G8C43_03240	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
G8C43_03255	ENOG4105D9R	oxidoreductase
G8C43_03275	ENOG4105EMU	Dehydrogenase
G8C43_03295	ENOG4108URH	decarboxylase
G8C43_03330	ENOG4108MCI	Transcriptional regulator, ARAC family
G8C43_03335	ENOG4105EXC	Acyl-transferase
G8C43_03400	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
G8C43_03405	ENOG4105VEJ	Heat shock protein
G8C43_03440	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
G8C43_03450	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
G8C43_03465	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
G8C43_03500	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
G8C43_03505	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
G8C43_03510	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
G8C43_03515	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
G8C43_03535	ENOG4105CH6	catalase
G8C43_03545	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
G8C43_03560	ENOG4107KET	secretion protein, HlyD family
G8C43_03570	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
G8C43_03590	ENOG4105DC1	bifunctional purine biosynthesis protein purh
G8C43_03605	ENOG4105VFU	Rna-binding protein
G8C43_03615	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
G8C43_03625	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
G8C43_03630	ENOG4105C6K	Malic enzyme
G8C43_03645	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
G8C43_03655	ENOG4105C5I	Dehydrogenase
G8C43_03660	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
G8C43_03710	ENOG4105E1F	short-chain dehydrogenase reductase
G8C43_03715	ENOG4108RMU	ferritin dps family protein
G8C43_03740	ENOG4105CFG	Acts as a chaperone (By similarity)
G8C43_03745	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
G8C43_03755	ENOG4105CDA	abc transporter atp-binding protein
G8C43_03770	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
G8C43_03785	ENOG4106WTF	Glycosyl transferase, family 2
G8C43_03800	ENOG4108RWI	nicotinamidase
G8C43_03805	ENOG4107RH7	Nicotinate phosphoribosyltransferase
G8C43_03810	ENOG4105CSC	Glucose uptake protein
G8C43_03815	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
G8C43_03825	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
G8C43_03845	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
G8C43_03865	ENOG4105E6M	Sulphatase-modifying factor protein
G8C43_03880	ENOG4105CFH	Aspartokinase
G8C43_03890	ENOG4105C0B	DNA polymerase III (alpha subunit)
G8C43_03905	ENOG4105KVH	Transcriptional regulator
G8C43_03935	ENOG4105C0P	Mg chelatase subunit ChlI
G8C43_03945	ENOG4105CI3	gtp-binding protein typa
G8C43_03950	ENOG4105K63	Thioredoxin
G8C43_03955	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
G8C43_03965	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
G8C43_03970	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
G8C43_03975	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
G8C43_03980	ENOG4105KJF	protein tyrosine phosphatase
G8C43_03990	ENOG4108Z0R	Transferase
G8C43_03995	ENOG4105WMR	Protein CrcB homolog
G8C43_04000	ENOG4105C03	ribonuclease
G8C43_04045	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
G8C43_04050	ENOG4105D3Q	Sugar transferase
G8C43_04055	ENOG4105BZU	Histidine kinase
G8C43_04065	ENOG4105CRK	lysyL-tRNA synthetase
G8C43_04110	ENOG4108IDZ	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
G8C43_04120	ENOG4105DQR	SNARE associated Golgi
G8C43_04125	ENOG4105K6V	RNA polymerase
G8C43_04140	ENOG4107SPE	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
G8C43_04160	ENOG4105R3P	Inner membrane protein yagU
G8C43_04165	ENOG4105CUT	histidyl-tRNA synthetase
G8C43_04190	ENOG4107QN2	dihydrolipoyl dehydrogenase
G8C43_04200	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
G8C43_04205	ENOG41083X6	30S ribosomal protein S21
G8C43_04210	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G8C43_04215	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
G8C43_04260	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
G8C43_04265	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
G8C43_04270	ENOG4107VNI	ribosomal protein l10
G8C43_04275	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
G8C43_04280	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G8C43_04285	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G8C43_04305	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
G8C43_04315	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
G8C43_04320	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
G8C43_04325	ENOG4108VVK	transcriptional Regulator, AsnC
G8C43_04330	ENOG4105DU1	integral membrane protein, terc
G8C43_04340	ENOG4105C2N	RNA methyltransferase TrmH family group 3
G8C43_04345	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
G8C43_04365	ENOG4105CUB	amino acid
G8C43_04370	ENOG4105C26	Dehydrogenase
G8C43_04385	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
G8C43_04390	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
G8C43_04395	ENOG4105F27	Major Facilitator
G8C43_04405	ENOG4105CG5	Glycosyl transferase (Group 1
G8C43_04415	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
G8C43_04440	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
G8C43_04450	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
G8C43_04455	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
G8C43_04465	ENOG4105CPP	Dehydrogenase, E1 component
G8C43_04470	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
G8C43_04495	ENOG4105CNI	cell division protein FtsW
G8C43_04505	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
G8C43_04520	ENOG4105EEI	dihydropteroate synthase
G8C43_04525	ENOG4105KCK	Peptidoglycan-associated lipoprotein
G8C43_04530	ENOG4108ZT0	50S ribosomal protein l17
G8C43_04535	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G8C43_04540	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
G8C43_04545	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
G8C43_04550	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G8C43_04555	ENOG410864M	50S ribosomal protein L36
G8C43_04560	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
G8C43_04565	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
G8C43_04570	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
G8C43_04575	ENOG41084HK	50S ribosomal protein L30
G8C43_04580	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
G8C43_04585	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
G8C43_04590	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
G8C43_04595	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
G8C43_04600	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
G8C43_04605	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G8C43_04615	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
G8C43_04620	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
G8C43_04625	ENOG4105WNB	50s ribosomal protein l29
G8C43_04630	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
G8C43_04635	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
G8C43_04640	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
G8C43_04645	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
G8C43_04650	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G8C43_04655	ENOG41082S5	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
G8C43_04660	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
G8C43_04665	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
G8C43_04675	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
G8C43_04690	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
G8C43_04705	ENOG4108J3C	UTP-glucose-1-phosphate uridylyltransferase
G8C43_04710	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
G8C43_04720	ENOG4105D7A	ATP-binding protein
G8C43_04725	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
G8C43_04730	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
G8C43_04745	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
G8C43_04775	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
G8C43_04830	ENOG4105C3R	Methionine synthase
G8C43_04835	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
G8C43_04840	ENOG4105GR3	Histidine kinase
G8C43_04845	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
G8C43_04870	ENOG4108YYC	ycei family
G8C43_04885	ENOG4105DQR	SNARE associated Golgi
G8C43_04890	ENOG4107QJT	sodium dicarboxylate symporter
G8C43_04905	ENOG4107QWP	ABC-2 type transporter
G8C43_04910	ENOG4105CJ1	ABC, transporter
G8C43_04915	ENOG4105CJ1	ABC, transporter
G8C43_04935	ENOG4107R0V	Pyruvate dehydrogenase
G8C43_04945	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
G8C43_04950	ENOG4105KG3	cytidine deaminase
G8C43_04955	ENOG4105SYT	Methylenetetrahydrofolate reductase
G8C43_04970	ENOG4105F71	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
G8C43_04975	ENOG4105CHU	acetyl-coa acetyltransferase
G8C43_05010	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
G8C43_05015	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
G8C43_05025	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
G8C43_05030	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
G8C43_05035	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
G8C43_05040	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
G8C43_05045	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
G8C43_05050	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
G8C43_05055	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
G8C43_05065	ENOG4105C5H	ABC transporter
G8C43_05090	ENOG4105E9Q	Acyl-transferase
G8C43_05095	ENOG4105DG6	mannose-6-phosphate isomerase
G8C43_05110	ENOG4105D7N	magnesium and cobalt transport protein CorA
G8C43_05115	ENOG4105C9M	aspartyl-trna synthetase
G8C43_05145	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
G8C43_05150	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
G8C43_05165	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8C43_05185	ENOG4105CUG	Oligopeptidase b
G8C43_05190	ENOG4105K8R	UPF0145 protein
G8C43_05205	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
G8C43_05210	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G8C43_05215	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
G8C43_05220	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G8C43_05225	ENOG4108IU3	tonb-dependent siderophore receptor
G8C43_05255	ENOG4105D3Q	Sugar transferase
G8C43_05275	ENOG4107Y2G	Glycosyl transferase (Group 1
G8C43_05305	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
G8C43_05320	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
G8C43_05345	ENOG4107SFQ	iron-sulfur binding
G8C43_05355	ENOG4105FA2	dna polymerase iii
G8C43_05360	ENOG4105CDU	Replicative dna helicase
G8C43_05365	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
G8C43_05370	ENOG4105VJV	50s ribosomal protein L35
G8C43_05380	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
G8C43_05385	ENOG4105C22	threonyL-tRNA synthetase
G8C43_05390	ENOG4108Z66	YbaK ebsC protein
G8C43_05395	ENOG4105CD3	dihydroorotase
G8C43_05400	ENOG410814C	multidrug resistance protein
G8C43_05405	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
G8C43_05410	ENOG4105C8S	subunit m
G8C43_05415	ENOG4105D65	subunit l
G8C43_05420	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
G8C43_05425	ENOG4105DF2	NADH dehydrogenase subunit j
G8C43_05430	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
G8C43_05435	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
G8C43_05500	ENOG4105CFH	Aspartokinase
G8C43_05505	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
G8C43_05510	ENOG4105D98	threonine synthase
G8C43_05515	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
G8C43_05520	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
G8C43_05535	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
G8C43_05555	ENOG4108VVK	transcriptional Regulator, AsnC
G8C43_05560	ENOG4105EYW	Ion transport protein
G8C43_05565	ENOG4108Z6B	deaminase
G8C43_05570	ENOG4107QXV	Phosphate transporter
G8C43_05580	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
G8C43_05590	ENOG4105C9U	ATP-dependent DNA helicase RecQ
G8C43_05595	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
G8C43_05625	ENOG4105C5H	ABC transporter
G8C43_05635	ENOG4105C59	p-type ATPase
G8C43_05655	ENOG4105C58	cytochrome c oxidase accessory protein ccog
G8C43_05690	ENOG4105MA4	psp1 domain protein
G8C43_05700	ENOG4108JQC	penicillin-binding protein 1A
G8C43_05710	ENOG4107RNH	Outer membrane receptor FepA
G8C43_05730	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
G8C43_05740	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
G8C43_05750	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
G8C43_05760	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
G8C43_05775	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
G8C43_05780	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
G8C43_05785	ENOG4107XZW	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
G8C43_05790	ENOG4105VG1	fes assembly suf system protein
G8C43_05795	ENOG4108Y6J	UPF0403 protein
G8C43_05800	ENOG4105WG6	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
G8C43_05820	ENOG4107QVM	von Willebrand factor, type A
G8C43_05825	ENOG4107QVM	von Willebrand factor, type A
G8C43_05840	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
G8C43_05845	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
G8C43_05855	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
G8C43_05865	ENOG4105CFP	Peptidase U32
G8C43_05870	ENOG4105DTD	Dehydrogenase
G8C43_05875	ENOG4107XCH	Cyclase family
G8C43_05880	ENOG4105CSA	Coproporphyrinogen iii oxidase
G8C43_05905	ENOG4107IQ5	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
G8C43_05925	ENOG4105D8G	Major Facilitator superfamily
G8C43_05935	ENOG4105CHR	reductase
G8C43_05945	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
G8C43_05980	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
G8C43_05995	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
G8C43_06000	ENOG4105JBQ	Pyrogenic exotoxin B
G8C43_06005	ENOG4105JBQ	Pyrogenic exotoxin B
G8C43_06010	ENOG4105JBQ	Pyrogenic exotoxin B
G8C43_06015	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
G8C43_06020	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
G8C43_06035	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
G8C43_06050	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
G8C43_06060	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
G8C43_06070	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
G8C43_06075	ENOG4105E0X	reductase
G8C43_06080	ENOG4105F4G	Membrane
G8C43_06085	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
G8C43_06105	ENOG4108RCM	Nitroreductase
G8C43_06110	ENOG4105K56	Transcriptional regulator
G8C43_06120	ENOG4108UMI	ABC transporter, permease
G8C43_06125	ENOG4105D01	(LipO)protein
G8C43_06130	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
G8C43_06145	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
G8C43_06150	ENOG4105BZ1	(ABC) transporter
G8C43_06160	ENOG4107TT5	NLP P60 protein
G8C43_06175	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
G8C43_06190	ENOG4105CUY	Mechanosensitive ion channel
G8C43_06200	ENOG4105C8F	Beta-lactamase domain protein
G8C43_06205	ENOG4105C6K	Malic enzyme
G8C43_06210	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
G8C43_06225	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
G8C43_06235	ENOG4105K6H	D-cysteine desulfhydrase
G8C43_06240	ENOG4105DUX	Transporter
G8C43_06245	ENOG4105DUX	Transporter
G8C43_06275	ENOG4107EEU	hydroxymethylglutaryL-CoA reductase
G8C43_06280	ENOG4107QUV	Domain protein
G8C43_06295	ENOG4108HFV	
G8C43_06315	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
G8C43_06320	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
G8C43_06330	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
G8C43_06345	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
G8C43_06350	ENOG4108DJF	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
G8C43_06360	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
G8C43_06365	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
G8C43_06370	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
G8C43_06375	ENOG4105D3R	alkyl hydroperoxide reductase
G8C43_06390	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
G8C43_06395	ENOG4105D52	delta-aminolevulinic acid dehydratase
G8C43_06410	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
G8C43_06415	ENOG4105CDY	transcriptional regulatory protein
G8C43_06430	ENOG4105DFA	alanine racemase domain protein
G8C43_06435	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
G8C43_06450	ENOG4107QQG	Dehydrogenase
G8C43_06455	ENOG4105K64	Glycosyl transferase, family 2
G8C43_06460	ENOG4107S6X	Glycosyl transferase, family 2
G8C43_06500	ENOG4105EY8	ABC transporter
G8C43_06505	ENOG4105MFV	ABC-2 type transporter
G8C43_06520	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
G8C43_06525	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
G8C43_06540	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
G8C43_06555	ENOG4108RWN	rrna methyltransferase
G8C43_06570	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
G8C43_06585	ENOG4105C5Z	peptidase
G8C43_06605	ENOG4105VAW	lrga family
G8C43_06610	ENOG41067MG	lrgb family
G8C43_06615	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
G8C43_06620	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
G8C43_06625	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
G8C43_06630	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
G8C43_06635	ENOG4105DK0	Indole-3-glycerol phosphate synthase
G8C43_06645	ENOG4108I0Q	anthranilate phosphoribosyltransferase
G8C43_06650	ENOG4105DDQ	anthranilate synthase
G8C43_06655	ENOG4108W2Y	isochorismatase
G8C43_06660	ENOG4105CRQ	synthase (Component I)
G8C43_06665	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
G8C43_06680	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
G8C43_06710	ENOG4108Z4V	iron-sulfur cluster assembly
G8C43_06715	ENOG4106HB6	Alpha beta hydrolase
G8C43_06720	ENOG4106VK6	Flagellar motor protein
G8C43_06730	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
G8C43_06740	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
G8C43_06745	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
G8C43_06750	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
G8C43_06760	ENOG4105CSM	endonuclease III
G8C43_06780	ENOG4105BZ1	(ABC) transporter
G8C43_06785	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
G8C43_06805	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G8C43_06810	ENOG4105CFH	Aspartokinase
G8C43_06820	ENOG4105BZA	Phosphoglycerate kinase
G8C43_06830	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
G8C43_06835	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
G8C43_06840	ENOG4105D78	K07001 NTE family protein
G8C43_06855	ENOG4105CG5	Glycosyl transferase (Group 1
G8C43_06865	ENOG4105CG5	Glycosyl transferase (Group 1
G8C43_06870	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
G8C43_06875	ENOG4107TAE	Glycosyl transferase (Group 1
G8C43_06930	ENOG4107QNK	)-transporter
G8C43_06945	ENOG4107GFK	fumarate
G8C43_06955	ENOG4108FN7	Aldo keto reductase
G8C43_06980	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
G8C43_06995	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
G8C43_07000	ENOG4105CXY	transporter
G8C43_07005	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
G8C43_07010	ENOG4105E98	transcriptional regulator DeoR family
G8C43_07015	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
G8C43_07025	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
G8C43_07030	ENOG4108IPT	Naphthoate synthase
G8C43_07035	ENOG4105C85	amino acid
G8C43_07040	ENOG4105EV9	Alpha Beta Hydrolase
G8C43_07045	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
G8C43_07055	ENOG41072GX	Peptidase M22 Glycoprotease
G8C43_07085	ENOG4105E9M	CRISPR-associated protein, Csn1 family
G8C43_07110	ENOG4105EMU	Dehydrogenase
G8C43_07115	ENOG4105E2X	shikimate dehydrogenase
G8C43_07120	ENOG4105HHA	aminodeoxychorismate lyase
G8C43_07130	ENOG4105I08	Pseudouridine synthase
G8C43_07150	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
G8C43_07165	ENOG4105D1Q	UPF0246 protein
G8C43_07195	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
G8C43_07200	ENOG4107T8J	thymidine kinase
G8C43_07210	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
G8C43_07215	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
G8C43_07225	ENOG4105C4R	Atp-dependent dna helicase
G8C43_07245	ENOG4105ENX	hydrolase
G8C43_07255	ENOG4108I0Z	Aconitate hydratase
G8C43_07260	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
G8C43_07275	ENOG4107SN7	NLP P60 protein
G8C43_07280	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
G8C43_07285	ENOG4106YN8	Prenyltransferase
G8C43_07290	ENOG4105IQ5	FAD linked oxidase domain protein
G8C43_07325	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
G8C43_07330	ENOG4105DF9	Lipoate-protein, ligase
G8C43_07335	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
G8C43_07345	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
G8C43_07350	ENOG4107TT5	NLP P60 protein
G8C43_07355	ENOG4105C5H	ABC transporter
G8C43_07360	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
G8C43_07375	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
G8C43_07380	ENOG4107RJC	Iron-containing alcohol dehydrogenase
G8C43_07400	ENOG4105C8P	)-transporter
G8C43_07405	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
G8C43_07410	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
G8C43_07430	ENOG4107R6T	Involved in the transcription termination process (By similarity)
G8C43_07445	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
G8C43_07450	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
G8C43_07460	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
G8C43_07465	ENOG4108UJD	30S ribosomal protein S9
G8C43_07470	ENOG4105CE9	30S ribosomal protein S2
G8C43_07475	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
G8C43_07485	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
G8C43_07490	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
G8C43_07500	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
G8C43_07505	ENOG4105D2N	Aldolase
G8C43_07520	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
G8C43_07530	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
G8C43_07535	ENOG4107RZZ	dna polymerase iii epsilon subunit
G8C43_07540	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
G8C43_07550	ENOG41090IP	Required for maturation of 30S ribosomal subunits (By similarity)
G8C43_07555	ENOG4105CHV	Transcription elongation factor NusA
G8C43_07560	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
G8C43_07565	ENOG4105C27	TonB-dependent Receptor Plug
G8C43_07590	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G8C43_07595	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
G8C43_07615	ENOG410631K	Membrane
G8C43_07625	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
G8C43_07630	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
G8C43_07640	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
G8C43_07645	ENOG4105DSJ	YicC domain protein
G8C43_07655	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
G8C43_07665	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
G8C43_07685	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
G8C43_07690	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
G8C43_07695	ENOG4108R6K	riboflavin synthase, subunit alpha
G8C43_07705	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
G8C43_07740	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
G8C43_07745	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
G8C43_07760	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
G8C43_07770	ENOG4108S4H	thioesterase Superfamily protein
G8C43_07785	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
G8C43_07790	ENOG4105D63	family UPF0324
G8C43_07795	ENOG41077A9	carbonic anhydrase
G8C43_07805	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
G8C43_07815	ENOG4105CXT	aspartate transcarbamylase
G8C43_07830	ENOG4105E0M	Sulfatase
G8C43_07840	ENOG410667J	hydrolase
G8C43_07845	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
G8C43_07850	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
G8C43_07855	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
G8C43_07865	ENOG4105CA9	Pyruvate kinase
G8C43_07885	ENOG4105F2Z	3-oxoadipate enol-lactonase
G8C43_07895	ENOG4108JA1	polyketide synthase
G8C43_07900	ENOG4108JA1	polyketide synthase
G8C43_07905	ENOG4105C3S	Mate efflux family protein
G8C43_07920	ENOG4105CX6	glutaminyL-tRNA synthetase
G8C43_07950	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
G8C43_07965	ENOG4105KTH	gatB Yqey
G8C43_07970	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
G8C43_07975	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
G8C43_07985	ENOG4105DFU	Cell wall formation (By similarity)
G8C43_07990	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
G8C43_07995	ENOG4105CNI	cell division protein FtsW
G8C43_08000	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
G8C43_08005	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
G8C43_08010	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
G8C43_08015	ENOG4105CJN	penicillin-binding protein
G8C43_08025	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
G8C43_08030	ENOG4107YM1	mraZ protein
G8C43_08035	ENOG4108MXF	Alpha Beta Hydrolase
G8C43_08040	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
G8C43_08045	ENOG4105C2N	RNA methyltransferase TrmH family group 3
G8C43_08065	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
G8C43_08070	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
G8C43_08080	ENOG4105C72	UPF0176 protein
G8C43_08085	ENOG4105C9K	Endothelin-converting enzyme 1
G8C43_08090	ENOG4105CAK	Cell division ATP-binding protein ftsE
G8C43_08115	ENOG4108YBP	pseudouridine synthase
G8C43_08120	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
G8C43_08125	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
G8C43_08135	ENOG4107RJ9	Cell division protein FtsX
G8C43_08140	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
G8C43_08160	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
G8C43_08170	ENOG41080R2	UPF0102 protein
G8C43_08175	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
G8C43_08180	ENOG4108HWS	Histidine kinase
G8C43_08190	ENOG4105BZ1	(ABC) transporter
G8C43_08210	ENOG4105HMI	Membrane
G8C43_08215	ENOG4105CH7	arginosuccinase
G8C43_08220	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
G8C43_08225	ENOG4107T6X	nag kinase
G8C43_08245	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
G8C43_08250	ENOG4105CDH	Citrulline--aspartate ligase
G8C43_08270	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
G8C43_08285	ENOG4105CNU	cell division protein FtsK
G8C43_08290	ENOG4105HFZ	Membrane
G8C43_08295	ENOG4108YZG	isomerase
G8C43_08300	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
G8C43_08310	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
G8C43_08315	ENOG4108ZP8	Acetolactate synthase small subunit
G8C43_08325	ENOG4105C7K	acetolactate synthase
G8C43_08335	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
G8C43_08340	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
G8C43_08345	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
G8C43_08350	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
G8C43_08355	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
G8C43_08360	ENOG4105DKW	ABC transporter
G8C43_08375	ENOG4105F8V	Hydrolase, tatD family
G8C43_08380	ENOG4108TGC	Acyltransferase
G8C43_08385	ENOG4105K46	50S ribosomal protein l27
G8C43_08390	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
G8C43_08395	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
G8C43_08400	ENOG4108HCJ	Hydrolase
G8C43_08415	ENOG4105DF6	Fe-S oxidoreductase
G8C43_08420	ENOG4105DF6	Fe-S oxidoreductase
G8C43_08455	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
G8C43_08460	ENOG4105CJW	magnesium transporter
G8C43_08475	ENOG4105C72	UPF0176 protein
G8C43_08480	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
G8C43_08485	ENOG4105KDC	50s ribosomal protein l28
G8C43_08490	ENOG41083ND	50S ribosomal protein L33
G8C43_08500	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
G8C43_08515	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
G8C43_08565	ENOG41080E8	Transcriptional regulator, Spx MgsR family
G8C43_08575	ENOG4105C31	Tryptophanyl-tRNA synthetase
G8C43_08580	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
G8C43_08590	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
G8C43_08595	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
G8C43_08600	ENOG410667J	hydrolase
G8C43_08605	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
G8C43_08615	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
G8C43_08690	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
G8C43_08700	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
G8C43_08720	ENOG4105RWS	endonuclease I
G8C43_08740	ENOG4108JA2	transcriptioN-repair coupling factor
G8C43_08750	ENOG4105CKK	Glycosyl transferase, family 2
G8C43_08755	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
G8C43_08760	ENOG4108ZJ4	polysaccharide deacetylase
G8C43_08790	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
G8C43_08810	ENOG4105DFH	Transport of potassium into the cell (By similarity)
G8C43_08815	ENOG4105CMR	udp-glucose 4-epimerase
G8C43_08820	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
G8C43_08825	ENOG4108IQE	Amp-dependent synthetase and ligase
G8C43_08835	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
G8C43_08845	ENOG4105CM2	brancheD-chain amino acid aminotransferase
G8C43_08865	ENOG4105C59	p-type ATPase
G8C43_08870	ENOG4105C1J	atp-dependent rna helicase
G8C43_08875	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
G8C43_08880	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
G8C43_08885	ENOG4108IJ0	Aspartate ammonia-lyase
G8C43_08890	ENOG4105D0C	transport protein
G8C43_08900	ENOG4105HDK	L-asparaginase
G8C43_08915	ENOG4107S8C	mandelate racemase muconate lactonizing
G8C43_08925	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
G8C43_08930	ENOG4107QR9	Iron-sulfur cluster binding protein
G8C43_08935	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
G8C43_08940	ENOG4107THF	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
G8C43_08945	ENOG4107S2Z	UPF0761 membrane protein
G8C43_08960	ENOG4107W2A	UPF0173 metal-dependent hydrolase
G8C43_08965	ENOG4105DGW	oligopeptidase A
G8C43_08980	ENOG4105W5Q	DNA repair protein (RadC
G8C43_09005	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
G8C43_09080	ENOG4108B02	Modulates RecA activity (By similarity)
G8C43_09085	ENOG4105K63	Thioredoxin
G8C43_09100	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
G8C43_09115	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
G8C43_09120	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
G8C43_09125	ENOG4108ZG0	Ompa motb domain protein
G8C43_09130	ENOG4105CGK	Exodeoxyribonuclease III
G8C43_09150	ENOG4105C4X	radical SAM domain protein
G8C43_09165	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
G8C43_09170	ENOG4105CHR	reductase
G8C43_09200	ENOG4105CPC	Aldo Keto reductase
G8C43_09205	ENOG4105CEV	competence damage-inducible protein
G8C43_09210	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
G8C43_09220	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
G8C43_09235	ENOG4108WBT	adenosyltransferase
G8C43_09245	ENOG4108RWN	rrna methyltransferase
G8C43_09255	ENOG4105BZU	Histidine kinase
G8C43_09260	ENOG4108IUZ	ABC transporter
G8C43_09275	ENOG4105CEP	NADH dehydrogenase
G8C43_09285	ENOG4105DR5	peptidase
G8C43_09290	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
G8C43_09325	ENOG4105CGY	Dna recombination protein
G8C43_09330	ENOG4105F32	YngK protein
G8C43_09335	ENOG4105C5E	polysaccharide biosynthesis protein
G8C43_09340	ENOG4105C75	arginyL-tRNA synthetase
G8C43_09350	ENOG4105C6E	dna polymerase iii
G8C43_09360	ENOG4108V1T	peptidylprolyl cis-trans isomerase
G8C43_09365	ENOG4108V1T	peptidylprolyl cis-trans isomerase
G8C43_09375	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
G8C43_09380	ENOG4105C8Y	Acetylornithine aminotransferase
G8C43_09385	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
G8C43_09390	ENOG4107VAM	peptidase, m28
G8C43_09400	ENOG4105DR5	peptidase
G8C43_09410	ENOG4105CKU	formyltetrahydrofolate synthetase
G8C43_09420	ENOG4105C98	muts2 protein
G8C43_09425	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
G8C43_09440	ENOG4108EKN	Biotin protein ligase C terminal domain
G8C43_09450	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
G8C43_09460	ENOG4105KNE	Phosphatidate cytidylyltransferase
G8C43_09465	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
G8C43_09470	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
G8C43_09480	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
G8C43_09510	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
G8C43_09520	ENOG4107RNH	Outer membrane receptor FepA
G8C43_09525	ENOG4105D5Q	Arginine ornithine antiporter
G8C43_09545	ENOG4105FJR	Lmbe family
G8C43_09555	ENOG41081WG	50s ribosomal protein l31
G8C43_09565	ENOG4105CEY	Amp-dependent synthetase and ligase
G8C43_09570	ENOG41062JF	Transcriptional regulator
G8C43_09580	ENOG4105CE1	Ferrous iron transport protein b
G8C43_09600	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
G8C43_09605	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
G8C43_09615	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
G8C43_09620	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
G8C43_09630	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
G8C43_09635	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
G8C43_09650	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
G8C43_09655	ENOG4105E98	transcriptional regulator DeoR family
G8C43_09660	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
G8C43_09665	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
G8C43_09670	ENOG4108MDK	Dehydrogenase
G8C43_09690	ENOG4105EF1	ribulokinase
G8C43_09695	ENOG4105CV1	Transketolase (EC 2.2.1.1)
G8C43_09725	ENOG4107ZT5	Thiol disulfide interchange protein
G8C43_09735	ENOG4105C8N	cysteinyl-tRNA synthetase
G8C43_09740	ENOG4105EUJ	GTP cyclohydrolase i
G8C43_09755	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
G8C43_09760	ENOG4108I6A	alcohol dehydrogenase
G8C43_09765	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
G8C43_09770	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
G8C43_09775	ENOG4107Z4P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
G8C43_09780	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
G8C43_09785	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
G8C43_09790	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
G8C43_09805	ENOG4105WXV	50S ribosomal protein L32
G8C43_09810	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
G8C43_09815	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
G8C43_09830	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
G8C43_09835	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
G8C43_09840	ENOG4108CSZ	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
G8C43_09850	ENOG4105EAA	nucleoside
G8C43_09865	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
G8C43_09870	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
G8C43_09875	ENOG4105C9Q	fumarate hydratase class II
G8C43_09880	ENOG4105CTQ	phosphohexokinase
G8C43_09885	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
G8C43_09890	ENOG4105VG0	50S ribosomal protein l34