locus-tag	class	description
K2W87_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K2W87_00010	COG0592	DNA-directed DNA polymerase activity
K2W87_00020	COG2501	S4 domain
K2W87_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K2W87_00030	COG0187	DNA topoisomerase II activity
K2W87_00050	COG0360	Binds together with S18 to 16S ribosomal RNA
K2W87_00055	COG0629	single-stranded DNA binding
K2W87_00070	COG0359	binds to the 23S rRNA
K2W87_00075	COG0305	Participates in initiation and elongation during chromosome replication
K2W87_00090	COG1695	Transcriptional regulator
K2W87_00095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K2W87_00100	COG4166	transmembrane transport
K2W87_00110	COG0436	Aminotransferase
K2W87_00120	COG1846	Transcriptional regulator
K2W87_00135	COG1027	Aspartate ammonia-lyase
K2W87_00140	COG0719	Fe-S assembly protein
K2W87_00150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K2W87_00155	COG0719	Fe-S assembly protein
K2W87_00160	COG0396	ATPase activity
K2W87_00170	COG1328	CTP reductase activity
K2W87_00175	COG3527	Alpha-acetolactate decarboxylase
K2W87_00210	COG1028	Short-chain dehydrogenase reductase Sdr
K2W87_00215	COG2153	protein acetylation
K2W87_00245	COG0745	RESPONSE REGULATOR receiver
K2W87_00250	COG5002	protein histidine kinase activity
K2W87_00265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K2W87_00270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K2W87_00295	COG1914	H( )-stimulated, divalent metal cation uptake system
K2W87_00300	COG0589	response to stress
K2W87_00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K2W87_00315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K2W87_00330	COG2211	Major facilitator Superfamily
K2W87_00340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K2W87_00345	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K2W87_00350	COG0352	thiamine-phosphate diphosphorylase activity
K2W87_00355	COG0351	phosphomethylpyrimidine kinase
K2W87_00360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K2W87_00370	COG1376	ErfK ybiS ycfS ynhG family protein
K2W87_00380	COG2801	Transposase and inactivated derivatives
K2W87_00395	COG0183	Belongs to the thiolase family
K2W87_00420	COG2132	Multicopper oxidase
K2W87_00425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K2W87_00435	COG2814	Major facilitator Superfamily
K2W87_00445	COG1253	flavin adenine dinucleotide binding
K2W87_00485	COG3613	nucleoside 2-deoxyribosyltransferase
K2W87_00490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K2W87_00505	COG2801	Transposase and inactivated derivatives
K2W87_00535	COG0463	Glycosyl transferase, family 2
K2W87_00540	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K2W87_00550	COG0745	RESPONSE REGULATOR receiver
K2W87_00555	COG5002	protein histidine kinase activity
K2W87_00565	COG0071	Belongs to the small heat shock protein (HSP20) family
K2W87_00570	COG0071	Belongs to the small heat shock protein (HSP20) family
K2W87_00580	COG3152	Membrane
K2W87_00635	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K2W87_00665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K2W87_00680	COG0789	Transcriptional regulator
K2W87_00710	COG1940	carbohydrate kinase activity
K2W87_00750	COG1695	Transcriptional regulator
K2W87_00785	COG1063	alcohol dehydrogenase
K2W87_00790	COG0531	amino acid
K2W87_00825	COG0656	L-ascorbic acid biosynthetic process
K2W87_00830	COG0789	Transcriptional regulator
K2W87_00835	COG3620	sequence-specific DNA binding
K2W87_00840	COG2801	Transposase and inactivated derivatives
K2W87_00850	COG1309	transcriptional regulator
K2W87_00880	COG0789	Transcriptional regulator
K2W87_00890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K2W87_00900	COG1268	BioY protein
K2W87_00930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K2W87_00940	COG0656	L-ascorbic acid biosynthetic process
K2W87_00945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K2W87_00965	COG1418	mRNA catabolic process
K2W87_00970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K2W87_00985	COG2188	Transcriptional regulator
K2W87_00995	COG0564	pseudouridine synthase activity
K2W87_01015	COG0004	ammonium transporteR
K2W87_01020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K2W87_01025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K2W87_01030	COG2011	ABC-type metal ion transport system permease component
K2W87_01035	COG1464	Belongs to the NlpA lipoprotein family
K2W87_01040	COG1854	S-ribosylhomocysteine lyase activity
K2W87_01055	COG1418	mRNA catabolic process
K2W87_01065	COG1393	Belongs to the ArsC family
K2W87_01070	COG0561	phosphatase activity
K2W87_01085	COG0492	ferredoxin-NADP+ reductase activity
K2W87_01095	COG1368	sulfuric ester hydrolase activity
K2W87_01120	COG1705	Flagellar rod assembly protein muramidase FlgJ
K2W87_01125	COG0861	Integral membrane protein TerC family
K2W87_01130	COG3118	belongs to the thioredoxin family
K2W87_01135	COG1757	Na H antiporter
K2W87_01145	COG1388	LysM domain
K2W87_01145	COG3584	3D domain protein
K2W87_01150	COG0540	Belongs to the ATCase OTCase family
K2W87_01160	COG0505	Belongs to the CarA family
K2W87_01165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K2W87_01170	COG0167	dihydroorotate dehydrogenase activity
K2W87_01175	COG3764	Sortase (surface protein transpeptidase)
K2W87_01200	COG0516	GMP reductase activity
K2W87_01205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K2W87_01210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K2W87_01260	COG0438	transferase activity, transferring glycosyl groups
K2W87_01280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K2W87_01315	COG0583	DNA-binding transcription factor activity
K2W87_01365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K2W87_01375	COG2801	Transposase and inactivated derivatives
K2W87_01385	COG0357	Ribosomal RNA small subunit methyltransferase G
K2W87_01390	COG1192	Involved in chromosome partitioning
K2W87_01395	COG1475	DNA binding
K2W87_01400	COG4481	Protein conserved in bacteria
K2W87_01405	COG0012	GTP binding
K2W87_01415	COG0516	GMP reductase activity
K2W87_01415	COG0517	IMP dehydrogenase activity
K2W87_01425	COG5002	protein histidine kinase activity
K2W87_01430	COG1686	Belongs to the peptidase S11 family
K2W87_01455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K2W87_01460	COG0628	permease
K2W87_01465	COG0588	phosphoglycerate mutase activity
K2W87_01490	COG2814	Major facilitator Superfamily
K2W87_01500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K2W87_01530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K2W87_01535	COG3973	AAA domain
K2W87_01545	COG0248	Ppx GppA phosphatase
K2W87_01560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K2W87_01565	COG1801	Protein of unknown function DUF72
K2W87_01570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2W87_01570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2W87_01575	COG0084	hydrolase, TatD family'
K2W87_01585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K2W87_01590	COG4466	Protein conserved in bacteria
K2W87_01595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K2W87_01600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K2W87_01605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K2W87_01610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K2W87_01620	COG0561	phosphatase activity
K2W87_01625	COG1078	dGTPase activity
K2W87_01635	COG3343	RNA polymerase activity
K2W87_01640	COG0504	CTP synthase activity
K2W87_01645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K2W87_01650	COG0254	rRNA binding
K2W87_01655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K2W87_01660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K2W87_01670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K2W87_01675	COG2337	Toxic component of a toxin-antitoxin (TA) module
K2W87_01685	COG0039	L-malate dehydrogenase activity
K2W87_01690	COG0193	aminoacyl-tRNA hydrolase activity
K2W87_01695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K2W87_01700	COG2244	polysaccharide biosynthetic process
K2W87_01705	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K2W87_01715	COG1098	S1 RNA binding domain
K2W87_01720	COG0037	tRNA processing
K2W87_01735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K2W87_01740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K2W87_01745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K2W87_01785	COG3104	oligopeptide transport
K2W87_01800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K2W87_01805	COG2188	Transcriptional regulator
K2W87_01815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K2W87_01830	COG2183	response to ionizing radiation
K2W87_01835	COG3091	SprT-like family
K2W87_01840	COG0083	homoserine kinase activity
K2W87_01860	COG1316	TRANSCRIPTIONal
K2W87_01865	COG0697	spore germination
K2W87_01870	COG0588	phosphoglycerate mutase activity
K2W87_01880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K2W87_01885	COG0756	dUTP diphosphatase activity
K2W87_01890	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K2W87_01895	COG4956	integral membrane protein (PIN domain superfamily)
K2W87_01900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K2W87_01905	COG0215	cysteine-tRNA ligase activity
K2W87_01910	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K2W87_01915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2W87_01920	COG3688	RNA-binding protein containing a PIN domain
K2W87_01930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K2W87_01935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K2W87_01940	COG0250	Participates in transcription elongation, termination and antitermination
K2W87_01945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K2W87_01950	COG0081	regulation of translation
K2W87_01955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K2W87_01960	COG0222	ribosome binding
K2W87_01965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K2W87_01965	COG0392	lysyltransferase activity
K2W87_01975	COG2801	Transposase and inactivated derivatives
K2W87_01980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K2W87_01985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K2W87_01990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K2W87_01995	COG2813	Specifically methylates the guanine in position
K2W87_02010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K2W87_02030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K2W87_02035	COG3870	Protein conserved in bacteria
K2W87_02040	COG0470	DNA polymerase III
K2W87_02045	COG4467	Involved in initiation control of chromosome replication
K2W87_02050	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K2W87_02060	COG1214	PFAM Peptidase M22, glycoprotease
K2W87_02070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K2W87_02075	COG0488	(ABC) transporter
K2W87_02080	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K2W87_02085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K2W87_02090	COG0459	protein refolding
K2W87_02095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K2W87_02100	COG1739	Uncharacterized protein family UPF0029
K2W87_02105	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K2W87_02115	COG0653	protein targeting
K2W87_02125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K2W87_02130	COG1983	PspC domain protein
K2W87_02135	COG1950	PFAM Membrane protein of
K2W87_02140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K2W87_02145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K2W87_02150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K2W87_02160	COG0492	ferredoxin-NADP+ reductase activity
K2W87_02165	COG0556	nucleotide-excision repair
K2W87_02170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K2W87_02175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K2W87_02180	COG1481	regulation of sporulation
K2W87_02185	COG0740	serine-type endopeptidase activity
K2W87_02205	COG0149	triose-phosphate isomerase activity
K2W87_02210	COG0148	phosphopyruvate hydratase activity
K2W87_02220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K2W87_02225	COG0557	exoribonuclease II activity
K2W87_02235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K2W87_02240	COG0280	phosphate acetyltransferase
K2W87_02245	COG0802	atpase or kinase
K2W87_02260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K2W87_02265	COG0025	NhaP-type Na H and K H
K2W87_02280	COG4856	YbbR-like protein
K2W87_02285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2W87_02290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K2W87_02300	COG1134	teichoic acid transport
K2W87_02310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K2W87_02325	COG3158	transport of potassium into the cell
K2W87_02340	COG0477	Major facilitator Superfamily
K2W87_02350	COG4975	Glucose uptake
K2W87_02365	COG0017	Asparaginyl-tRNA synthetase
K2W87_02370	COG1942	4-Oxalocrotonate Tautomerase
K2W87_02375	COG0604	alcohol dehydrogenase
K2W87_02375	COG1028	Short-chain dehydrogenase reductase Sdr
K2W87_02375	COG3321	synthase
K2W87_02390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K2W87_02395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K2W87_02415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K2W87_02420	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
K2W87_02425	COG1518	maintenance of DNA repeat elements
K2W87_02465	COG3759	membrane
K2W87_02470	COG0366	Alpha amylase catalytic
K2W87_02470	COG5263	repeat protein
K2W87_02475	COG1335	isochorismatase
K2W87_02495	COG1132	(ABC) transporter
K2W87_02500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K2W87_02505	COG3442	glutamine amidotransferase
K2W87_02510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K2W87_02515	COG1435	thymidine kinase activity
K2W87_02525	COG2890	protein-(glutamine-N5) methyltransferase activity
K2W87_02530	COG0009	L-threonylcarbamoyladenylate synthase
K2W87_02535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K2W87_02540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K2W87_02545	COG0356	it plays a direct role in the translocation of protons across the membrane
K2W87_02550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K2W87_02555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K2W87_02560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K2W87_02565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K2W87_02570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K2W87_02575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K2W87_02580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K2W87_02590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K2W87_02595	COG1077	Cell shape determining protein MreB Mrl
K2W87_02600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K2W87_02610	COG0772	Belongs to the SEDS family
K2W87_02615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K2W87_02620	COG2011	ABC-type metal ion transport system permease component
K2W87_02625	COG1464	Belongs to the NlpA lipoprotein family
K2W87_02630	COG2188	Transcriptional regulator
K2W87_02635	COG1131	(ABC) transporter
K2W87_02645	COG1181	Belongs to the D-alanine--D-alanine ligase family
K2W87_02650	COG0519	Catalyzes the synthesis of GMP from XMP
K2W87_02660	COG0589	response to stress
K2W87_02670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K2W87_02680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K2W87_02685	COG1956	GAF domain-containing protein
K2W87_02690	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K2W87_02695	COG1104	cysteine desulfurase activity
K2W87_02700	COG0301	tRNA thio-modification
K2W87_02710	COG0525	valine-tRNA ligase activity
K2W87_02715	COG0285	dihydrofolate synthase activity
K2W87_02720	COG1077	Cell shape determining protein MreB Mrl
K2W87_02735	COG0850	regulation of cytokinetic process
K2W87_02740	COG2894	cell division
K2W87_02745	COG0765	amino acid transport
K2W87_02750	COG1126	abc transporter atp-binding protein
K2W87_02755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K2W87_02765	COG0612	Peptidase, M16
K2W87_02770	COG1426	Protein conserved in bacteria
K2W87_02775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K2W87_02780	COG1058	Belongs to the CinA family
K2W87_02780	COG1546	Belongs to the CinA family
K2W87_02785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K2W87_02795	COG1692	metallophosphoesterase
K2W87_02800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K2W87_02805	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K2W87_02815	COG2255	four-way junction helicase activity
K2W87_02820	COG1862	Preprotein translocase
K2W87_02825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K2W87_02830	COG0513	Belongs to the DEAD box helicase family
K2W87_02835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K2W87_02840	COG4472	Bacterial protein of unknown function (DUF965)
K2W87_02850	COG3906	Belongs to the UPF0473 family
K2W87_02865	COG1193	negative regulation of DNA recombination
K2W87_02870	COG3118	belongs to the thioredoxin family
K2W87_02875	COG1719	4-vinyl reductase, 4VR
K2W87_02885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K2W87_02900	COG1609	Transcriptional regulator
K2W87_02905	COG0217	transcriptional regulatory protein
K2W87_02910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K2W87_02915	COG1459	type II secretion system
K2W87_02920	COG4537	Required for transformation and DNA binding
K2W87_02935	COG0827	DNA restriction-modification system
K2W87_02945	COG1113	amino acid transport
K2W87_02955	COG0737	Belongs to the 5'-nucleotidase family
K2W87_02960	COG4470	Protein conserved in bacteria
K2W87_02965	COG0647	UMP catabolic process
K2W87_02975	COG0586	Pfam SNARE associated Golgi protein
K2W87_02980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K2W87_03060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K2W87_03065	COG0477	Major facilitator Superfamily
K2W87_03070	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K2W87_03075	COG0495	leucyl-tRNA aminoacylation
K2W87_03080	COG2244	polysaccharide biosynthetic process
K2W87_03090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K2W87_03100	COG1428	Deoxynucleoside kinase
K2W87_03120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K2W87_03125	COG0367	asparagine synthase
K2W87_03140	COG1794	racemase activity, acting on amino acids and derivatives
K2W87_03165	COG0018	arginyl-trna synthetase
K2W87_03170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K2W87_03175	COG0420	3'-5' exonuclease activity
K2W87_03180	COG4717	serine-type aminopeptidase activity
K2W87_03185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K2W87_03195	COG0537	adenosine 5'-monophosphoramidase activity
K2W87_03200	COG1131	(ABC) transporter
K2W87_03210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K2W87_03215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K2W87_03220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2W87_03225	COG1674	ftsk spoiiie
K2W87_03230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K2W87_03240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K2W87_03240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K2W87_03245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K2W87_03250	COG0237	dephospho-CoA kinase activity
K2W87_03255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K2W87_03260	COG3611	Membrane attachment protein
K2W87_03265	COG1484	DNA-dependent DNA replication
K2W87_03270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K2W87_03275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K2W87_03280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K2W87_03285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K2W87_03295	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K2W87_03300	COG1534	Rna-binding protein
K2W87_03305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K2W87_03310	COG1713	HD superfamily hydrolase involved in NAD metabolism
K2W87_03315	COG0799	negative regulation of ribosome biogenesis
K2W87_03320	COG2226	methyltransferase
K2W87_03325	COG1323	Belongs to the UPF0348 family
K2W87_03335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K2W87_03340	COG0745	RESPONSE REGULATOR receiver
K2W87_03345	COG5002	protein histidine kinase activity
K2W87_03355	COG0187	DNA topoisomerase II activity
K2W87_03365	COG0583	DNA-binding transcription factor activity
K2W87_03370	COG1227	inorganic diphosphatase activity
K2W87_03400	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K2W87_03405	COG1307	EDD domain protein, DegV family
K2W87_03420	COG0386	Belongs to the glutathione peroxidase family
K2W87_03450	COG0505	Belongs to the CarA family
K2W87_03455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K2W87_03460	COG0564	pseudouridine synthase activity
K2W87_03465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K2W87_03480	COG0328	RNA-DNA hybrid ribonuclease activity
K2W87_03485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2W87_03490	COG0116	Belongs to the methyltransferase superfamily
K2W87_03505	COG4474	Belongs to the UPF0398 family
K2W87_03510	COG3331	DNA recombination
K2W87_03535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K2W87_03550	COG1304	FMN binding
K2W87_03575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K2W87_03575	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K2W87_03580	COG0561	phosphatase activity
K2W87_03590	COG1942	4-Oxalocrotonate Tautomerase
K2W87_03600	COG0335	large ribosomal subunit rRNA binding
K2W87_03605	COG0336	Belongs to the RNA methyltransferase TrmD family
K2W87_03610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K2W87_03620	COG0228	four-way junction DNA binding
K2W87_03640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K2W87_03645	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K2W87_03650	COG0552	protein localization to endoplasmic reticulum
K2W87_03655	COG1196	nuclear chromosome segregation
K2W87_03660	COG0571	ribonuclease III activity
K2W87_03665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2W87_03670	COG0416	fatty acid biosynthetic process
K2W87_03675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K2W87_03680	COG1461	Dihydroxyacetone kinase
K2W87_03685	COG1302	Protein conserved in bacteria
K2W87_03690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K2W87_03695	COG1564	THIamine pyrophosphokinase
K2W87_03700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K2W87_03705	COG1162	GTPase activity
K2W87_03715	COG0631	protein serine/threonine phosphatase activity
K2W87_03720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K2W87_03720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K2W87_03725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K2W87_03730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K2W87_03735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K2W87_03745	COG0194	GDP metabolic process
K2W87_03750	COG0497	DNA recombination
K2W87_03755	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K2W87_03760	COG0142	geranyltranstransferase activity
K2W87_03765	COG1722	exodeoxyribonuclease VII activity
K2W87_03770	COG1570	exodeoxyribonuclease VII activity
K2W87_03775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K2W87_03780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K2W87_03785	COG1302	Protein conserved in bacteria
K2W87_03790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K2W87_03795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K2W87_03805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K2W87_03825	COG0789	Transcriptional regulator
K2W87_03845	COG1940	carbohydrate kinase activity
K2W87_03860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K2W87_03865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K2W87_03870	COG0768	penicillin binding
K2W87_03880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K2W87_03885	COG0572	uridine kinase
K2W87_03890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K2W87_03895	COG0072	phenylalanine-tRNA ligase activity
K2W87_03895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2W87_03900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K2W87_03905	COG1733	regulation of RNA biosynthetic process
K2W87_03915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2W87_03920	COG1254	Belongs to the acylphosphatase family
K2W87_03925	COG0706	membrane insertase activity
K2W87_03940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K2W87_03945	COG0758	DNA mediated transformation
K2W87_03970	COG2755	lipolytic protein G-D-S-L family
K2W87_03980	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K2W87_03985	COG0488	(ABC) transporter
K2W87_04010	COG1160	GTP binding
K2W87_04015	COG0539	negative regulation of cytoplasmic translation
K2W87_04020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K2W87_04030	COG0514	ATP-dependent DNA helicase (RecQ)
K2W87_04040	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K2W87_04045	COG1187	pseudouridine synthase activity
K2W87_04050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K2W87_04060	COG0456	acetyltransferase
K2W87_04070	COG2996	Protein conserved in bacteria
K2W87_04080	COG0587	DNA-directed DNA polymerase activity
K2W87_04090	COG0542	response to heat
K2W87_04100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K2W87_04105	COG2384	SAM-dependent methyltransferase
K2W87_04110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K2W87_04115	COG0358	DNA primase activity
K2W87_04120	COG0751	glycine-tRNA ligase activity
K2W87_04125	COG0752	glycyl-tRNA synthetase alpha subunit
K2W87_04130	COG1381	Involved in DNA repair and RecF pathway recombination
K2W87_04135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K2W87_04140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K2W87_04145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K2W87_04150	COG1702	phosphate starvation-inducible protein PhoH
K2W87_04155	COG1610	YqeY-like protein
K2W87_04160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K2W87_04165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K2W87_04170	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K2W87_04175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K2W87_04180	COG1682	transport, permease protein
K2W87_04185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K2W87_04190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K2W87_04195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K2W87_04200	COG0124	histidyl-tRNA synthetase
K2W87_04205	COG3001	Fructosamine kinase
K2W87_04210	COG0546	phosphoglycolate phosphatase activity
K2W87_04215	COG1490	D-aminoacyl-tRNA deacylase activity
K2W87_04220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K2W87_04225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K2W87_04230	COG2264	protein methyltransferase activity
K2W87_04245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K2W87_04250	COG2233	PERMEase
K2W87_04255	COG0481	GTPase activity
K2W87_04260	COG0484	heat shock protein binding
K2W87_04275	COG1420	regulation of RNA biosynthetic process
K2W87_04280	COG0196	riboflavin kinase activity
K2W87_04285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K2W87_04290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K2W87_04295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K2W87_04305	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K2W87_04310	COG0195	Participates in both transcription termination and antitermination
K2W87_04315	COG0779	Required for maturation of 30S ribosomal subunits
K2W87_04320	COG2176	DNA-directed DNA polymerase activity
K2W87_04325	COG0442	prolyl-tRNA aminoacylation
K2W87_04330	COG0750	zinc metalloprotease
K2W87_04335	COG4589	Belongs to the CDS family
K2W87_04340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K2W87_04350	COG0233	cytoplasmic translational termination
K2W87_04355	COG0528	UMP kinase activity
K2W87_04360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K2W87_04365	COG0052	Belongs to the universal ribosomal protein uS2 family
K2W87_04370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K2W87_04375	COG2827	Endonuclease containing a URI domain
K2W87_04380	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K2W87_04385	COG0204	Acyl-transferase
K2W87_04390	COG3763	UPF0154 protein
K2W87_04395	COG4224	UPF0291 protein
K2W87_04400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K2W87_04410	COG3425	synthase
K2W87_04430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K2W87_04435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K2W87_04435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K2W87_04440	COG1234	tRNA 3'-trailer cleavage
K2W87_04445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K2W87_04450	COG0322	excinuclease ABC activity
K2W87_04465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K2W87_04470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K2W87_04475	COG0544	peptidyl-prolyl cis-trans isomerase activity
K2W87_04480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K2W87_04495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K2W87_04505	COG1466	dna polymerase III delta subunit
K2W87_04510	COG2333	competence protein COMEC
K2W87_04510	COG0658	competence protein
K2W87_04515	COG2131	deaminase
K2W87_04525	COG3480	Lon protease (S16) C-terminal proteolytic domain
K2W87_04530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K2W87_04535	COG0742	ribosomal rna small subunit methyltransferase
K2W87_04540	COG4471	UPF0298 protein
K2W87_04550	COG1217	gtp-binding protein TYPA
K2W87_04555	COG0483	inositol monophosphate 1-phosphatase activity
K2W87_04565	COG0039	L-malate dehydrogenase activity
K2W87_04570	COG0242	peptide deformylase activity
K2W87_04580	COG5503	Protein of unknown function (DUF1447)
K2W87_04590	COG1597	lipid kinase activity
K2W87_04600	COG0667	Aldo Keto reductase
K2W87_04605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K2W87_04610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K2W87_04625	COG0482	sulfurtransferase activity
K2W87_04635	COG1104	cysteine desulfurase activity
K2W87_04640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K2W87_04650	COG0494	nUDIX hydrolase
K2W87_04655	COG1278	Cold shock
K2W87_04660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K2W87_04665	COG3599	regulation of cell shape
K2W87_04675	COG1799	cell septum assembly
K2W87_04690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K2W87_04695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K2W87_04705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K2W87_04710	COG0768	penicillin binding
K2W87_04720	COG0275	rRNA processing
K2W87_04740	COG1674	ftsk spoiiie
K2W87_04750	COG0500	methyltransferase
K2W87_04755	COG0564	pseudouridine synthase activity
K2W87_04760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K2W87_04765	COG2357	RelA SpoT domain protein
K2W87_04775	COG1164	Oligoendopeptidase f
K2W87_04785	COG4862	establishment of competence for transformation
K2W87_04790	COG1234	tRNA 3'-trailer cleavage
K2W87_04940	COG1368	sulfuric ester hydrolase activity
K2W87_04950	COG0438	transferase activity, transferring glycosyl groups
K2W87_04955	COG0438	transferase activity, transferring glycosyl groups
K2W87_04965	COG0542	response to heat
K2W87_04975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K2W87_04980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K2W87_04985	COG0628	permease
K2W87_04990	COG2137	regulation of response to DNA damage stimulus
K2W87_04995	COG0716	FMN binding
K2W87_05000	COG1295	ribonuclease BN
K2W87_05005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K2W87_05010	COG0463	Glycosyl transferase, family 2
K2W87_05015	COG2246	polysaccharide biosynthetic process
K2W87_05020	COG2610	gluconate transmembrane transporter activity
K2W87_05035	COG0704	Plays a role in the regulation of phosphate uptake
K2W87_05040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K2W87_05050	COG0581	inorganic phosphate transmembrane transporter activity
K2W87_05055	COG0573	inorganic phosphate transmembrane transporter activity
K2W87_05080	COG3409	Peptidoglycan-binding domain 1 protein
K2W87_05080	COG3757	hydrolase, family 25
K2W87_05085	COG1070	Carbohydrate kinase
K2W87_05090	COG0531	amino acid
K2W87_05095	COG2378	regulation of single-species biofilm formation
K2W87_05115	COG2801	Transposase and inactivated derivatives
K2W87_05135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K2W87_05140	COG1597	lipid kinase activity
K2W87_05145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K2W87_05150	COG0154	amidase activity
K2W87_05155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K2W87_05160	COG4851	CamS sex pheromone cAM373 precursor
K2W87_05165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K2W87_05175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K2W87_05180	COG1705	Flagellar rod assembly protein muramidase FlgJ
K2W87_05190	COG4684	Psort location CytoplasmicMembrane, score
K2W87_05195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K2W87_05200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K2W87_05205	COG0101	tRNA pseudouridine synthase activity
K2W87_05210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K2W87_05215	COG1122	ATPase activity
K2W87_05225	COG0203	ribosomal protein L17
K2W87_05230	COG0202	RNA polymerase activity
K2W87_05235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K2W87_05240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K2W87_05250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K2W87_05255	COG0563	adenylate kinase activity
K2W87_05265	COG0200	Binds to the 23S rRNA
K2W87_05270	COG1841	ribosomal large subunit assembly
K2W87_05275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K2W87_05285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K2W87_05290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K2W87_05295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K2W87_05300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K2W87_05305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K2W87_05310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K2W87_05325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K2W87_05330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K2W87_05335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K2W87_05345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K2W87_05350	COG0089	rRNA binding
K2W87_05355	COG0088	Forms part of the polypeptide exit tunnel
K2W87_05360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K2W87_05365	COG0051	transcription antitermination factor activity, RNA binding
K2W87_05370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K2W87_05375	COG0049	tRNA binding
K2W87_05380	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K2W87_05390	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K2W87_05395	COG0085	RNA polymerase activity
K2W87_05400	COG0542	response to heat
K2W87_05405	COG4463	regulation of RNA biosynthetic process
K2W87_05450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K2W87_05455	COG1428	Deoxynucleoside kinase
K2W87_05460	COG0833	amino acid
K2W87_05480	COG0730	response to heat
K2W87_05530	COG0564	pseudouridine synthase activity
K2W87_05535	COG3338	carbonate dehydratase activity
K2W87_05545	COG1053	succinate dehydrogenase
K2W87_05550	COG1064	alcohol dehydrogenase
K2W87_05555	COG0697	spore germination
K2W87_05560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K2W87_05565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K2W87_05595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K2W87_05595	COG0519	Catalyzes the synthesis of GMP from XMP
K2W87_05600	COG1072	(Pantothenic acid kinase))
K2W87_05605	COG3973	AAA domain
K2W87_05610	COG0406	alpha-ribazole phosphatase activity
K2W87_05615	COG4608	Belongs to the ABC transporter superfamily
K2W87_05620	COG0444	Belongs to the ABC transporter superfamily
K2W87_05625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K2W87_05630	COG0601	transmembrane transport
K2W87_05635	COG4166	transmembrane transport
K2W87_05640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K2W87_05655	COG0194	GDP metabolic process
K2W87_05665	COG2936	dipeptidyl-peptidase activity
K2W87_05670	COG2267	carboxylic ester hydrolase activity
K2W87_05680	COG0488	(ABC) transporter
K2W87_05690	COG0531	amino acid
K2W87_05700	COG4120	Belongs to the binding-protein-dependent transport system permease family
K2W87_05705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K2W87_05710	COG2084	Dehydrogenase
K2W87_05735	COG0583	DNA-binding transcription factor activity
K2W87_05740	COG0531	amino acid
K2W87_05750	COG1686	Belongs to the peptidase S11 family
K2W87_05760	COG1122	ATPase activity
K2W87_05785	COG2233	PERMEase
K2W87_05810	COG1307	EDD domain protein, DegV family
K2W87_05825	COG2706	6-phosphogluconolactonase activity
K2W87_05830	COG0833	amino acid
K2W87_05835	COG2040	homocysteine
K2W87_05845	COG0735	belongs to the Fur family
K2W87_05850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K2W87_05855	COG0436	Aminotransferase
K2W87_05860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K2W87_05865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K2W87_05870	COG1473	amidohydrolase
K2W87_05875	COG2171	N-acyltransferase activity
K2W87_05880	COG0019	diaminopimelate decarboxylase activity
K2W87_05885	COG0527	aspartate kinase activity
K2W87_05890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K2W87_05905	COG2814	Major facilitator Superfamily
K2W87_05910	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
K2W87_05915	COG0436	Aminotransferase
K2W87_05950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K2W87_05965	COG4946	Tricorn protease homolog
K2W87_05965	COG0823	Involved in the tonB-independent uptake of proteins
K2W87_05965	COG1506	peptidase
K2W87_05995	COG3590	peptidase
K2W87_06000	COG0789	Transcriptional regulator
K2W87_06005	COG2249	NAD(P)H dehydrogenase (quinone) activity
K2W87_06015	COG2814	Major facilitator Superfamily
K2W87_06025	COG0024	Methionine aminopeptidase
K2W87_06030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K2W87_06040	COG0110	maltose O-acetyltransferase activity
K2W87_06045	COG0328	RNA-DNA hybrid ribonuclease activity
K2W87_06050	COG0351	phosphomethylpyrimidine kinase
K2W87_06060	COG2249	NAD(P)H dehydrogenase (quinone) activity
K2W87_06070	COG1278	Cold shock
K2W87_06105	COG3961	Belongs to the TPP enzyme family
K2W87_06115	COG0697	spore germination
K2W87_06120	COG0531	amino acid
K2W87_06130	COG2409	Drug exporters of the RND superfamily
K2W87_06130	COG1033	growth of symbiont in host cell
K2W87_06140	COG0697	spore germination
K2W87_06145	COG0656	L-ascorbic acid biosynthetic process
K2W87_06150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K2W87_06155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2W87_06160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K2W87_06170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K2W87_06175	COG0825	malonyl-CoA metabolic process
K2W87_06180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K2W87_06185	COG0439	Biotin carboxylase
K2W87_06190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K2W87_06200	COG1028	Short-chain dehydrogenase reductase Sdr
K2W87_06205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K2W87_06210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2W87_06215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2W87_06220	COG0778	Nitroreductase
K2W87_06225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2W87_06250	COG0488	(ABC) transporter
K2W87_06255	COG0702	epimerase
K2W87_06285	COG2323	membrane
K2W87_06295	COG2801	Transposase and inactivated derivatives
K2W87_06310	COG1272	protein, Hemolysin III
K2W87_06320	COG1131	(ABC) transporter
K2W87_06335	COG1846	Transcriptional regulator
K2W87_06340	COG1113	amino acid transport
K2W87_06345	COG1113	amino acid transport
K2W87_06350	COG0531	amino acid
K2W87_06360	COG0446	pyridine nucleotide-disulphide oxidoreductase
K2W87_06370	COG5263	repeat protein
K2W87_06370	COG0366	Alpha amylase catalytic
K2W87_06375	COG0366	Alpha amylase catalytic
K2W87_06375	COG5263	repeat protein
K2W87_06385	COG4166	transmembrane transport
K2W87_06420	COG1215	transferase activity, transferring glycosyl groups
K2W87_06425	COG0297	glycogen (starch) synthase activity
K2W87_06425	COG0438	transferase activity, transferring glycosyl groups
K2W87_06430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K2W87_06435	COG4464	protein tyrosine phosphatase activity
K2W87_06440	COG0489	protein tyrosine kinase activity
K2W87_06450	COG1316	TRANSCRIPTIONal
K2W87_06475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K2W87_06485	COG1114	Component of the transport system for branched-chain amino acids
K2W87_06495	COG1114	Component of the transport system for branched-chain amino acids
K2W87_06505	COG1704	LemA family
K2W87_06530	COG0114	fumarate hydratase activity
K2W87_06550	COG3279	Response regulator of the LytR AlgR family
K2W87_06570	COG4166	transmembrane transport
K2W87_06575	COG4166	transmembrane transport
K2W87_06580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K2W87_06610	COG1388	LysM domain
K2W87_06620	COG3527	Alpha-acetolactate decarboxylase
K2W87_06625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K2W87_06635	COG0693	protein deglycase activity
K2W87_06690	COG0028	Belongs to the TPP enzyme family
K2W87_06710	COG0702	epimerase
K2W87_06715	COG1959	2 iron, 2 sulfur cluster binding
K2W87_06725	COG2814	Major facilitator Superfamily
K2W87_06735	COG0151	Belongs to the GarS family
K2W87_06740	COG0138	bifunctional purine biosynthesis protein purh
K2W87_06745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K2W87_06750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K2W87_06760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K2W87_06775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K2W87_06780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K2W87_06785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K2W87_06790	COG1686	Belongs to the peptidase S11 family
K2W87_06800	COG2801	Transposase and inactivated derivatives
K2W87_06830	COG0366	Alpha amylase catalytic
K2W87_06830	COG5263	repeat protein
K2W87_06870	COG1476	TRANSCRIPTIONal
K2W87_06875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K2W87_06895	COG0460	homoserine dehydrogenase
K2W87_06905	COG0083	homoserine kinase activity
K2W87_06935	COG0584	glycerophosphoryl diester phosphodiesterase
K2W87_06960	COG1136	(ABC) transporter
K2W87_06975	COG0446	pyridine nucleotide-disulphide oxidoreductase
K2W87_07005	COG0577	efflux transmembrane transporter activity
K2W87_07005	COG1136	(ABC) transporter
K2W87_07010	COG1309	transcriptional regulator
K2W87_07015	COG0668	transmembrane transport
K2W87_07020	COG0668	transmembrane transport
K2W87_07025	COG0765	amino acid transport
K2W87_07030	COG1126	abc transporter atp-binding protein
K2W87_07035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K2W87_07045	COG0583	DNA-binding transcription factor activity
K2W87_07070	COG0765	amino acid transport
K2W87_07075	COG1126	abc transporter atp-binding protein
K2W87_07085	COG2814	Major facilitator Superfamily
K2W87_07095	COG2855	membrane
K2W87_07100	COG1454	alcohol dehydrogenase
K2W87_07100	COG1012	belongs to the aldehyde dehydrogenase family
K2W87_07105	COG4152	abc transporter atp-binding protein
K2W87_07115	COG1074	ATP-dependent DNA helicase activity
K2W87_07120	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K2W87_07150	COG2801	Transposase and inactivated derivatives
K2W87_07160	COG1113	amino acid transport
K2W87_07165	COG1113	amino acid transport
K2W87_07180	COG0667	Aldo Keto reductase
K2W87_07185	COG2252	PERMEase
K2W87_07210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K2W87_07215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K2W87_07220	COG1940	carbohydrate kinase activity
K2W87_07230	COG0346	lactoylglutathione lyase activity
K2W87_07235	COG0481	GTPase activity
K2W87_07240	COG1309	transcriptional regulator
K2W87_07255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K2W87_07260	COG1121	(ABC) transporter
K2W87_07265	COG0860	N-Acetylmuramoyl-L-alanine amidase
K2W87_07265	COG3103	Sh3 type 3 domain protein
K2W87_07265	COG4991	sh3 domain protein
K2W87_07285	COG2814	Major facilitator Superfamily
K2W87_07290	COG0284	orotidine-5'-phosphate decarboxylase activity
K2W87_07295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K2W87_07310	COG4166	transmembrane transport
K2W87_07325	COG0460	homoserine dehydrogenase
K2W87_07335	COG2873	o-acetylhomoserine
K2W87_07340	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K2W87_07345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K2W87_07380	COG1126	abc transporter atp-binding protein
K2W87_07385	COG0765	amino acid transport
K2W87_07395	COG0137	argininosuccinate synthase activity
K2W87_07425	COG0681	Belongs to the peptidase S26 family
K2W87_07435	COG0445	tRNA wobble uridine modification
K2W87_07440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K2W87_07445	COG1847	R3H domain protein
K2W87_07450	COG0706	membrane insertase activity
K2W87_07455	COG0594	ribonuclease P activity
K2W87_07460	COG0230	Belongs to the bacterial ribosomal protein bL34 family