locus-tag	class	description
CUN60_00010	COG0438	transferase activity, transferring glycosyl groups
CUN60_00015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CUN60_00070	COG1773	rubredoxin
CUN60_00085	COG2171	N-acyltransferase activity
CUN60_00090	COG2816	NAD+ diphosphatase activity
CUN60_00105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUN60_00105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUN60_00110	COG0509	glycine decarboxylation via glycine cleavage system
CUN60_00115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CUN60_00155	COG0308	aminopeptidase N
CUN60_00185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CUN60_00190	COG0039	L-malate dehydrogenase activity
CUN60_00205	COG2814	Major facilitator Superfamily
CUN60_00210	COG1505	serine-type exopeptidase activity
CUN60_00230	COG0484	heat shock protein binding
CUN60_00235	COG1301	dicarboxylic acid transport
CUN60_00250	COG1272	protein, Hemolysin III
CUN60_00265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CUN60_00275	COG1739	Uncharacterized protein family UPF0029
CUN60_00280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CUN60_00290	COG0450	alkyl hydroperoxide reductase
CUN60_00295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CUN60_00300	COG0783	Belongs to the Dps family
CUN60_00315	COG1366	Belongs to the anti-sigma-factor antagonist family
CUN60_00315	COG2202	Pas domain
CUN60_00340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CUN60_00345	COG1183	phosphatidylcholine synthase activity
CUN60_00350	COG0688	phosphatidylethanolamine metabolic process
CUN60_00360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUN60_00360	COG0519	Catalyzes the synthesis of GMP from XMP
CUN60_00365	COG0528	UMP kinase activity
CUN60_00375	COG0284	orotidine-5'-phosphate decarboxylase activity
CUN60_00385	COG3961	Belongs to the TPP enzyme family
CUN60_00390	COG3397	chitin binding
CUN60_00455	COG0602	queuosine metabolic process
CUN60_00465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CUN60_00470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CUN60_00470	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CUN60_00475	COG0302	gtp cyclohydrolase
CUN60_00490	COG0481	GTPase activity
CUN60_00500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CUN60_00515	COG0477	Major facilitator Superfamily
CUN60_00530	COG4948	Mandelate Racemase Muconate Lactonizing
CUN60_00570	COG1490	D-aminoacyl-tRNA deacylase activity
CUN60_00580	COG1090	epimerase
CUN60_00615	COG0318	PFAM AMP-dependent synthetase and ligase
CUN60_00625	COG0069	glutamate synthase activity
CUN60_00640	COG0402	S-adenosylhomocysteine deaminase activity
CUN60_00645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CUN60_00650	COG0583	DNA-binding transcription factor activity
CUN60_00655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CUN60_00660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CUN60_00665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CUN60_00705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CUN60_00710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CUN60_00715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CUN60_00725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CUN60_00740	COG0356	it plays a direct role in the translocation of protons across the membrane
CUN60_00750	COG0215	cysteine-tRNA ligase activity
CUN60_00755	COG2204	response regulator
CUN60_00765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CUN60_00765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUN60_00785	COG1519	Transferase
CUN60_00790	COG4221	oxidoreductase activity
CUN60_00795	COG1192	Involved in chromosome partitioning
CUN60_00795	COG1192	Involved in chromosome partitioning
CUN60_00825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CUN60_00840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CUN60_00860	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CUN60_00885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUN60_00890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CUN60_00905	COG1404	Belongs to the peptidase S8 family
CUN60_00920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CUN60_00940	COG0556	nucleotide-excision repair
CUN60_00945	COG0572	uridine kinase
CUN60_00950	COG0572	uridine kinase
CUN60_00985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CUN60_00990	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CUN60_01005	COG0813	purine-nucleoside phosphorylase activity
CUN60_01015	COG0295	cytidine deaminase activity
CUN60_01025	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUN60_01060	COG0583	DNA-binding transcription factor activity
CUN60_01065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CUN60_01130	COG0625	glutathione transferase activity
CUN60_01140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUN60_01155	COG0583	DNA-binding transcription factor activity
CUN60_01165	COG2197	response regulator
CUN60_01175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CUN60_01185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CUN60_01195	COG2833	Protein of unknown function (DUF455)
CUN60_01200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CUN60_01210	COG1845	cytochrome c oxidase, subunit III
CUN60_01215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CUN60_01220	COG0109	protoheme IX farnesyltransferase activity
CUN60_01235	COG1678	Uncharacterized ACR, COG1678
CUN60_01240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CUN60_01275	COG2086	electron transfer activity
CUN60_01285	COG0741	lytic transglycosylase activity
CUN60_01285	COG1388	LysM domain
CUN60_01290	COG1760	l-serine dehydratase
CUN60_01295	COG1530	ribonuclease E activity
CUN60_01310	COG1063	alcohol dehydrogenase
CUN60_01315	COG0156	8-amino-7-oxononanoate synthase activity
CUN60_01320	COG0140	phosphoribosyl-ATP diphosphatase activity
CUN60_01320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CUN60_01325	COG0107	imidazoleglycerol-phosphate synthase activity
CUN60_01330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUN60_01335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CUN60_01335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CUN60_01360	COG0531	amino acid
CUN60_01365	COG1538	Outer membrane efflux protein
CUN60_01380	COG0445	tRNA wobble uridine modification
CUN60_01395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUN60_01410	COG0167	dihydroorotate dehydrogenase activity
CUN60_01425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CUN60_01425	COG0543	2 iron, 2 sulfur cluster binding
CUN60_01485	COG1410	methionine synthase
CUN60_01485	COG0646	methionine synthase
CUN60_01490	COG1324	tolerance protein
CUN60_01505	COG0813	purine-nucleoside phosphorylase activity
CUN60_01510	COG4689	acetoacetate decarboxylase
CUN60_01530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CUN60_01540	COG4178	(ABC) transporter
CUN60_01545	COG0142	geranyltranstransferase activity
CUN60_01550	COG0590	tRNA wobble adenosine to inosine editing
CUN60_01585	COG2814	Major facilitator Superfamily
CUN60_01600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUN60_01605	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CUN60_01625	COG2070	2-Nitropropane dioxygenase
CUN60_01630	COG0488	(ABC) transporter
CUN60_01655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUN60_01665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CUN60_01670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CUN60_01685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUN60_01695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUN60_01695	COG0519	Catalyzes the synthesis of GMP from XMP
CUN60_01700	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CUN60_01720	COG0450	alkyl hydroperoxide reductase
CUN60_01725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CUN60_01735	COG2267	carboxylic ester hydrolase activity
CUN60_01755	COG1802	Transcriptional regulator
CUN60_01765	COG0156	8-amino-7-oxononanoate synthase activity
CUN60_01775	COG2226	methyltransferase
CUN60_01810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CUN60_01815	COG0183	Belongs to the thiolase family
CUN60_01820	COG3243	poly(R)-hydroxyalkanoic acid synthase
CUN60_01825	COG0475	glutathione-regulated potassium exporter activity
CUN60_01830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CUN60_01855	COG1028	Short-chain dehydrogenase reductase Sdr
CUN60_01870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUN60_01895	COG0598	Magnesium transport protein CorA
CUN60_01900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CUN60_01915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CUN60_01925	COG0826	peptidase U32
CUN60_01930	COG3104	oligopeptide transport
CUN60_01940	COG0477	Major facilitator Superfamily
CUN60_01960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CUN60_01970	COG4221	oxidoreductase activity
CUN60_01980	COG0242	peptide deformylase activity
CUN60_01990	COG0758	DNA mediated transformation
CUN60_02020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CUN60_02040	COG1573	uracil-dna glycosylase
CUN60_02050	COG1214	PFAM Peptidase M22, glycoprotease
CUN60_02055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CUN60_02060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CUN60_02065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUN60_02070	COG0640	Transcriptional regulator
CUN60_02110	COG2001	Belongs to the MraZ family
CUN60_02115	COG0275	rRNA processing
CUN60_02130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CUN60_02135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CUN60_02140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUN60_02145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CUN60_02150	COG0772	Belongs to the SEDS family
CUN60_02155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CUN60_02160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CUN60_02165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CUN60_02175	COG3104	oligopeptide transport
CUN60_02180	COG1722	exodeoxyribonuclease VII activity
CUN60_02185	COG0142	geranyltranstransferase activity
CUN60_02190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CUN60_02205	COG2190	(PTS) system
CUN60_02205	COG2211	Major facilitator Superfamily
CUN60_02240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CUN60_02245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CUN60_02260	COG0375	protein maturation
CUN60_02275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CUN60_02290	COG0527	aspartate kinase activity
CUN60_02295	COG2326	polyphosphate kinase activity
CUN60_02300	COG0626	cystathionine gamma-synthase activity
CUN60_02315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CUN60_02315	COG0189	ligase activity
CUN60_02330	COG1446	asparaginase
CUN60_02340	COG0251	oxidation-reduction process
CUN60_02345	COG2249	NAD(P)H dehydrogenase (quinone) activity
CUN60_02370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CUN60_02375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CUN60_02380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CUN60_02390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CUN60_02395	COG1074	ATP-dependent DNA helicase activity
CUN60_02400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CUN60_02410	COG3038	cytochrome b561
CUN60_02420	COG0538	isocitrate dehydrogenase activity
CUN60_02480	COG3384	dioxygenase
CUN60_02485	COG1741	Belongs to the pirin family
CUN60_02495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CUN60_02500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CUN60_02505	COG0126	phosphoglycerate kinase activity
CUN60_02510	COG0017	Asparaginyl-tRNA synthetase
CUN60_02540	COG1561	YicC-like family, N-terminal region
CUN60_02555	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CUN60_02560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUN60_02565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CUN60_02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
CUN60_02580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CUN60_02595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CUN60_02610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CUN60_02620	COG4221	oxidoreductase activity
CUN60_02625	COG0513	Belongs to the DEAD box helicase family
CUN60_02695	COG1959	2 iron, 2 sulfur cluster binding
CUN60_02720	COG0251	oxidation-reduction process
CUN60_02745	COG0405	Gamma-glutamyltransferase
CUN60_02750	COG0386	Belongs to the glutathione peroxidase family
CUN60_02765	COG0312	modulator of DNA gyrase
CUN60_02795	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CUN60_02805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CUN60_02810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CUN60_02820	COG0165	Argininosuccinate lyase
CUN60_02825	COG0137	argininosuccinate synthase activity
CUN60_02830	COG0505	Belongs to the CarA family
CUN60_02835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUN60_02840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CUN60_02845	COG0004	ammonium transporteR
CUN60_02850	COG0493	'glutamate synthase
CUN60_02855	COG0069	glutamate synthase activity
CUN60_02855	COG0067	glutamate synthase
CUN60_02855	COG0070	glutamate synthase
CUN60_02860	COG1113	amino acid transport
CUN60_02865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CUN60_02870	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CUN60_02875	COG3527	Alpha-acetolactate decarboxylase
CUN60_02885	COG0281	malic enzyme
CUN60_02890	COG0514	ATP-dependent DNA helicase (RecQ)
CUN60_02895	COG2814	Major facilitator Superfamily
CUN60_02900	COG0268	Binds directly to 16S ribosomal RNA
CUN60_02905	COG1113	amino acid transport
CUN60_02910	COG1113	amino acid transport
CUN60_02915	COG0613	PHP domain protein
CUN60_02925	COG1335	isochorismatase
CUN60_02935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CUN60_02955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CUN60_02960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CUN60_02965	COG1127	ABC transporter
CUN60_02975	COG0322	excinuclease ABC activity
CUN60_03000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CUN60_03025	COG3012	SEC-C Motif Domain Protein
CUN60_03030	COG0596	Alpha beta hydrolase
CUN60_03040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CUN60_03050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CUN60_03055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUN60_03125	COG0616	signal peptide processing
CUN60_03135	COG1294	oxidase, subunit
CUN60_03140	COG1271	oxidase subunit
CUN60_03155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CUN60_03170	COG0300	oxidoreductase activity
CUN60_03190	COG3852	Histidine kinase
CUN60_03205	COG0415	Belongs to the DNA photolyase family
CUN60_03210	COG3046	protein related to deoxyribodipyrimidine photolyase
CUN60_03215	COG3145	DNA-N1-methyladenine dioxygenase activity
CUN60_03225	COG0009	L-threonylcarbamoyladenylate synthase
CUN60_03235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CUN60_03245	COG2274	protein secretion by the type I secretion system
CUN60_03270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CUN60_03275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CUN60_03295	COG0285	dihydrofolate synthase activity
CUN60_03330	COG2252	PERMEase
CUN60_03350	COG0583	DNA-binding transcription factor activity
CUN60_03365	COG2917	probably involved in intracellular septation
CUN60_03370	COG0149	triose-phosphate isomerase activity
CUN60_03375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CUN60_03385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUN60_03390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUN60_03395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUN60_03400	COG0649	NAD binding
CUN60_03405	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CUN60_03420	COG1034	ATP synthesis coupled electron transport
CUN60_03425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CUN60_03430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUN60_03440	COG0713	ATP synthesis coupled electron transport
CUN60_03455	COG1007	ATP synthesis coupled electron transport
CUN60_03490	COG0516	GMP reductase activity
CUN60_03500	COG1660	Displays ATPase and GTPase activities
CUN60_03505	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CUN60_03510	COG0799	negative regulation of ribosome biogenesis
CUN60_03520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CUN60_03520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CUN60_03525	COG0583	DNA-binding transcription factor activity
CUN60_03530	COG0583	DNA-binding transcription factor activity
CUN60_03545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUN60_03545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUN60_03560	COG0252	asparaginase activity
CUN60_03570	COG0424	maF-like protein
CUN60_03575	COG1530	ribonuclease E activity
CUN60_03605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CUN60_03605	COG0284	orotidine-5'-phosphate decarboxylase activity
CUN60_03610	COG0505	Belongs to the CarA family
CUN60_03620	COG0540	Belongs to the ATCase OTCase family
CUN60_03625	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CUN60_03645	COG2095	MarC family integral membrane protein
CUN60_03655	COG2801	Transposase and inactivated derivatives
CUN60_03740	COG2132	Multicopper oxidase
CUN60_03760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CUN60_03770	COG1956	GAF domain-containing protein
CUN60_03835	COG0657	acetylesterase activity
CUN60_03855	COG0037	tRNA processing
CUN60_03860	COG0825	malonyl-CoA metabolic process
CUN60_03875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CUN60_03880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CUN60_03895	COG0114	fumarate hydratase activity
CUN60_03910	COG1054	Belongs to the UPF0176 family
CUN60_03920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CUN60_03925	COG0416	fatty acid biosynthetic process
CUN60_03930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CUN60_03935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CUN60_03970	COG2251	uridine kinase activity
CUN60_03970	COG0195	Participates in both transcription termination and antitermination
CUN60_03975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CUN60_03980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CUN60_03985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CUN60_04010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUN60_04015	COG1522	sequence-specific DNA binding
CUN60_04045	COG1566	PFAM secretion protein HlyD family protein
CUN60_04065	COG1940	carbohydrate kinase activity
CUN60_04075	COG5297	Belongs to the glycosyl hydrolase family 6
CUN60_04075	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CUN60_04080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CUN60_04085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CUN60_04090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CUN60_04090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUN60_04095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CUN60_04100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CUN60_04105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CUN60_04115	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CUN60_04125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CUN60_04130	COG0586	Pfam SNARE associated Golgi protein
CUN60_04145	COG3142	Participates in the control of copper homeostasis
CUN60_04215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CUN60_04220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CUN60_04225	COG1077	Cell shape determining protein MreB Mrl
CUN60_04245	COG0772	Belongs to the SEDS family
CUN60_04265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CUN60_04275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CUN60_04335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CUN60_04345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CUN60_04350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUN60_04355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUN60_04360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CUN60_04370	COG1217	gtp-binding protein TYPA
CUN60_04385	COG1301	dicarboxylic acid transport
CUN60_04390	COG1027	Aspartate ammonia-lyase
CUN60_04395	COG0252	asparaginase activity
CUN60_04405	COG0358	DNA primase activity
CUN60_04410	COG0531	amino acid
CUN60_04420	COG0438	transferase activity, transferring glycosyl groups
CUN60_04430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CUN60_04435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CUN60_04460	COG1132	(ABC) transporter
CUN60_04465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CUN60_04470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CUN60_04475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CUN60_04480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUN60_04490	COG0562	UDP-galactopyranose mutase
CUN60_04495	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CUN60_04500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUN60_04515	COG1216	Glycosyl transferase, family 2
CUN60_04530	COG1215	transferase activity, transferring glycosyl groups
CUN60_04560	COG3104	oligopeptide transport
CUN60_04565	COG1682	transport, permease protein
CUN60_04580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUN60_04595	COG1216	Glycosyl transferase, family 2
CUN60_04595	COG1442	glycosyl transferase family 8
CUN60_04610	COG0438	transferase activity, transferring glycosyl groups
CUN60_04620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CUN60_04655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CUN60_04705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CUN60_04715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CUN60_04720	COG0072	phenylalanine-tRNA ligase activity
CUN60_04720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUN60_04725	COG0776	regulation of translation
CUN60_04735	COG1294	oxidase, subunit
CUN60_04740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CUN60_04750	COG0312	modulator of DNA gyrase
CUN60_04760	COG0708	Exodeoxyribonuclease III
CUN60_04765	COG2081	HI0933 family
CUN60_04770	COG0850	regulation of cytokinetic process
CUN60_04780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CUN60_04785	COG0492	ferredoxin-NADP+ reductase activity
CUN60_04805	COG1404	Belongs to the peptidase S8 family
CUN60_04840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CUN60_04840	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CUN60_04855	COG0367	asparagine synthase
CUN60_04860	COG2217	Heavy metal translocating P-type atpase
CUN60_04890	COG1605	Chorismate mutase
CUN60_04890	COG0287	Prephenate dehydrogenase
CUN60_04900	COG0489	protein tyrosine kinase activity
CUN60_04905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUN60_04905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUN60_04925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CUN60_04930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CUN60_04945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CUN60_04950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUN60_04965	COG1120	ATPase activity
CUN60_04980	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CUN60_04995	COG1012	belongs to the aldehyde dehydrogenase family
CUN60_05025	COG2137	regulation of response to DNA damage stimulus
CUN60_05030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CUN60_05035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CUN60_05050	COG0606	chelatase, subunit chli
CUN60_05055	COG2960	long-chain fatty acid transporting porin activity
CUN60_05060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CUN60_05065	COG0531	amino acid
CUN60_05075	COG0741	lytic transglycosylase activity
CUN60_05085	COG4221	oxidoreductase activity
CUN60_05095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CUN60_05100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CUN60_05140	COG1289	transmembrane transporter activity
CUN60_05145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CUN60_05185	COG0022	dehydrogenase e1 component
CUN60_05200	COG1122	ATPase activity
CUN60_05210	COG0833	amino acid
CUN60_05220	COG0477	Major facilitator Superfamily
CUN60_05225	COG0737	Belongs to the 5'-nucleotidase family
CUN60_05235	COG0668	transmembrane transport
CUN60_05245	COG1301	dicarboxylic acid transport
CUN60_05250	COG0019	diaminopimelate decarboxylase activity
CUN60_05260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CUN60_05265	COG0105	UTP biosynthetic process
CUN60_05270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CUN60_05275	COG0791	NLP P60 protein
CUN60_05275	COG1388	LysM domain
CUN60_05280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CUN60_05285	COG0124	histidyl-tRNA synthetase
CUN60_05295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CUN60_05300	COG1160	GTP binding
CUN60_05310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CUN60_05325	COG0166	Belongs to the GPI family
CUN60_05340	COG0477	Major facilitator Superfamily
CUN60_05370	COG0802	atpase or kinase
CUN60_05375	COG0860	N-Acetylmuramoyl-L-alanine amidase
CUN60_05380	COG1187	pseudouridine synthase activity
CUN60_05395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CUN60_05400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CUN60_05425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CUN60_05450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CUN60_05455	COG4535	Mg2 and Co2 transporter CorC
CUN60_05460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CUN60_05470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CUN60_05490	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CUN60_05500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CUN60_05505	COG0443	Heat shock 70 kDa protein
CUN60_05510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CUN60_05515	COG0477	Major facilitator Superfamily
CUN60_05520	COG2211	Major facilitator Superfamily
CUN60_05545	COG2801	Transposase and inactivated derivatives
CUN60_05595	COG0778	Nitroreductase
CUN60_05605	COG0596	Alpha beta hydrolase
CUN60_05610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CUN60_05615	COG0594	ribonuclease P activity
CUN60_05620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CUN60_05625	COG0706	membrane insertase activity
CUN60_05655	COG2814	Major facilitator Superfamily
CUN60_05665	COG1538	Outer membrane efflux protein
CUN60_05670	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CUN60_05675	COG2095	MarC family integral membrane protein
CUN60_05785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CUN60_05790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CUN60_05795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUN60_05805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CUN60_05820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CUN60_05835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CUN60_05855	COG0778	Nitroreductase
CUN60_05880	COG1496	oxidoreductase activity
CUN60_05900	COG0740	serine-type endopeptidase activity
CUN60_05910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CUN60_05935	COG1295	ribonuclease BN
CUN60_05955	COG0439	Biotin carboxylase
CUN60_05960	COG0511	ligase activity, forming carbon-carbon bonds
CUN60_05965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CUN60_05975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CUN60_05980	COG2255	four-way junction helicase activity
CUN60_06000	COG0033	Phosphoglucomutase
CUN60_06025	COG1012	belongs to the aldehyde dehydrogenase family
CUN60_06035	COG0156	8-amino-7-oxononanoate synthase activity
CUN60_06070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CUN60_06085	COG2814	Major facilitator Superfamily
CUN60_06090	COG1566	PFAM secretion protein HlyD family protein
CUN60_06125	COG1216	Glycosyl transferase, family 2
CUN60_06135	COG0363	glucosamine-6-phosphate deaminase activity
CUN60_06140	COG1643	Atp-dependent helicase
CUN60_06145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CUN60_06155	COG0492	ferredoxin-NADP+ reductase activity
CUN60_06160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CUN60_06170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CUN60_06195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CUN60_06205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CUN60_06235	COG0788	formyltetrahydrofolate deformylase activity
CUN60_06240	COG0058	SHG alpha-glucan phosphorylase activity
CUN60_06245	COG1640	4-alpha-glucanotransferase
CUN60_06250	COG1288	antiporter activity
CUN60_06265	COG1113	amino acid transport
CUN60_06270	COG0655	NAD(P)H dehydrogenase (quinone) activity
CUN60_06295	COG2337	Toxic component of a toxin-antitoxin (TA) module
CUN60_06340	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CUN60_06355	COG1028	Short-chain dehydrogenase reductase Sdr
CUN60_06360	COG2211	Major facilitator Superfamily
CUN60_06370	COG3842	ATPase activity
CUN60_06375	COG1176	ABC-type spermidine putrescine transport system, permease component I
CUN60_06380	COG1177	transmembrane transport
CUN60_06390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CUN60_06400	COG1295	ribonuclease BN
CUN60_06405	COG0151	Belongs to the GarS family
CUN60_06410	COG2326	polyphosphate kinase activity
CUN60_06430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CUN60_06435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CUN60_06445	COG0629	single-stranded DNA binding
CUN60_06455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CUN60_06470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CUN60_06470	COG2169	Transcriptional regulator
CUN60_06475	COG0484	heat shock protein binding
CUN60_06490	COG0393	Putative heavy-metal-binding
CUN60_06500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CUN60_06505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CUN60_06530	COG2308	Evidence 4 Homologs of previously reported genes of
CUN60_06540	COG2814	Major facilitator Superfamily
CUN60_06545	COG1566	PFAM secretion protein HlyD family protein
CUN60_06555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CUN60_06555	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CUN60_06560	COG0328	RNA-DNA hybrid ribonuclease activity
CUN60_06575	COG2094	Belongs to the DNA glycosylase MPG family
CUN60_06585	COG4178	(ABC) transporter
CUN60_06595	COG0629	single-stranded DNA binding
CUN60_06605	COG0583	DNA-binding transcription factor activity
CUN60_06655	COG2814	Major facilitator Superfamily
CUN60_06725	COG0531	amino acid
CUN60_06735	COG0010	Belongs to the arginase family
CUN60_06740	COG0531	amino acid
CUN60_06750	COG1166	arginine decarboxylase activity
CUN60_06755	COG0626	cystathionine gamma-synthase activity
CUN60_06765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CUN60_06775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CUN60_06800	COG4974	Belongs to the 'phage' integrase family
CUN60_06840	COG1742	UPF0060 membrane protein
CUN60_06855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUN60_06880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CUN60_06900	COG2890	protein-(glutamine-N5) methyltransferase activity
CUN60_06910	COG2824	Alkylphosphonate utilization operon protein PhnA
CUN60_06930	COG1215	transferase activity, transferring glycosyl groups
CUN60_07125	COG1937	Protein conserved in bacteria
CUN60_07145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUN60_07285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CUN60_07295	COG1605	Chorismate mutase
CUN60_07295	COG0077	Prephenate dehydratase
CUN60_07305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CUN60_07310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CUN60_07315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUN60_07320	COG1312	Catalyzes the dehydration of D-mannonate
CUN60_07340	COG0217	transcriptional regulatory protein
CUN60_07355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CUN60_07360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CUN60_07365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CUN60_07380	COG0494	nUDIX hydrolase
CUN60_07390	COG0730	response to heat
CUN60_07395	COG2814	Major facilitator Superfamily
CUN60_07420	COG0006	proline dipeptidase activity
CUN60_07425	COG2095	MarC family integral membrane protein
CUN60_07430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CUN60_07440	COG0793	Belongs to the peptidase S41A family
CUN60_07445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUN60_07450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CUN60_07460	COG1263	PTS System
CUN60_07460	COG2190	(PTS) system
CUN60_07460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUN60_07465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUN60_07465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CUN60_07470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CUN60_07500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CUN60_07505	COG0277	FAD linked oxidase domain protein
CUN60_07520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CUN60_07525	COG2867	negative regulation of translational initiation
CUN60_07535	COG1686	Belongs to the peptidase S11 family
CUN60_07550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUN60_07595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CUN60_07600	COG0463	Glycosyl transferase, family 2
CUN60_07615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CUN60_07620	COG0571	ribonuclease III activity
CUN60_07630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CUN60_07655	COG3655	Transcriptional regulator
CUN60_07665	COG2091	lysine biosynthetic process via aminoadipic acid
CUN60_07680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CUN60_07685	COG0800	Aldolase
CUN60_07690	COG0800	Aldolase
CUN60_07695	COG0129	dihydroxy-acid dehydratase activity
CUN60_07715	COG1902	pentaerythritol trinitrate reductase activity
CUN60_07740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CUN60_07745	COG1181	Belongs to the D-alanine--D-alanine ligase family
CUN60_07745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CUN60_07760	COG1301	dicarboxylic acid transport
CUN60_07790	COG0018	arginyl-trna synthetase
CUN60_07795	COG0625	glutathione transferase activity
CUN60_07800	COG2969	positive regulation of protein catabolic process
CUN60_07805	COG0425	Belongs to the sulfur carrier protein TusA family
CUN60_07810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CUN60_07815	COG2814	Major facilitator Superfamily
CUN60_07825	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUN60_07855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CUN60_07860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CUN60_07875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CUN60_07880	COG0742	ribosomal rna small subunit methyltransferase
CUN60_07900	COG0513	Belongs to the DEAD box helicase family
CUN60_07910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUN60_07910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUN60_07915	COG0307	riboflavin synthase, alpha
CUN60_07920	COG2814	Major facilitator Superfamily
CUN60_07925	COG2814	Major facilitator Superfamily
CUN60_07935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUN60_07935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUN60_07945	COG0285	dihydrofolate synthase activity
CUN60_07950	COG0302	gtp cyclohydrolase
CUN60_07990	COG0326	Molecular chaperone. Has ATPase activity
CUN60_08000	COG0633	Ferredoxin
CUN60_08010	COG0626	cystathionine gamma-synthase activity
CUN60_08015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CUN60_08020	COG1555	photosystem II stabilization
CUN60_08025	COG1666	GTP binding
CUN60_08030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CUN60_08040	COG1464	Belongs to the NlpA lipoprotein family
CUN60_08050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CUN60_08055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CUN60_08085	COG0546	phosphoglycolate phosphatase activity
CUN60_08105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CUN60_08120	COG1132	(ABC) transporter
CUN60_08125	COG3781	membrane
CUN60_08130	COG0443	Heat shock 70 kDa protein
CUN60_08145	COG0822	iron-sulfur transferase activity
CUN60_08150	COG1104	cysteine desulfurase activity
CUN60_08200	COG4106	trans-aconitate 2-methyltransferase activity
CUN60_08210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CUN60_08220	COG0473	3-isopropylmalate dehydrogenase activity
CUN60_08225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUN60_08230	COG0028	Belongs to the TPP enzyme family
CUN60_08235	COG0440	acetolactate synthase activity
CUN60_08240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CUN60_08250	COG0254	rRNA binding
CUN60_08265	COG0038	chloride channel
CUN60_08270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CUN60_08275	COG3264	Mechanosensitive ion channel
CUN60_08275	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CUN60_08300	COG2610	gluconate transmembrane transporter activity
CUN60_08305	COG3038	cytochrome b561
CUN60_08315	COG1461	Dihydroxyacetone kinase
CUN60_08325	COG0542	response to heat
CUN60_08335	COG1929	Belongs to the glycerate kinase type-1 family
CUN60_08355	COG1959	2 iron, 2 sulfur cluster binding
CUN60_08360	COG0477	Major facilitator Superfamily
CUN60_08375	COG2801	Transposase and inactivated derivatives
CUN60_08385	COG0148	phosphopyruvate hydratase activity
CUN60_08400	COG0504	CTP synthase activity
CUN60_08410	COG1119	ATPase activity
CUN60_08415	COG2989	Protein conserved in bacteria
CUN60_08420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CUN60_08490	COG2165	general secretion pathway protein
CUN60_08495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CUN60_08500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CUN60_08510	COG0735	belongs to the Fur family
CUN60_08520	COG1450	Type ii and iii secretion system protein
CUN60_08555	COG0346	lactoylglutathione lyase activity
CUN60_08560	COG0470	DNA polymerase III
CUN60_08565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CUN60_08570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CUN60_08575	COG0557	exoribonuclease II activity
CUN60_08590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CUN60_08600	COG0628	permease
CUN60_08605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CUN60_08635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CUN60_08655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CUN60_08660	COG0617	tRNA 3'-terminal CCA addition
CUN60_08665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CUN60_08670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CUN60_08680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CUN60_08685	COG0159	tryptophan synthase activity
CUN60_08690	COG0133	tryptophan synthase activity
CUN60_08700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CUN60_08705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CUN60_08705	COG0512	Glutamine amidotransferase of anthranilate synthase
CUN60_08730	COG2885	chlorophyll binding
CUN60_08740	COG0583	DNA-binding transcription factor activity
CUN60_08780	COG0601	transmembrane transport
CUN60_08785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CUN60_08800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CUN60_08810	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CUN60_08820	COG0084	hydrolase, TatD family'
CUN60_08835	COG3876	Protein conserved in bacteria
CUN60_08860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CUN60_08875	COG1994	Peptidase M50
CUN60_08880	COG0180	Tryptophanyl-tRNA synthetase
CUN60_08885	COG0024	Methionine aminopeptidase
CUN60_08900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CUN60_08925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUN60_08930	COG0798	PFAM Bile acid sodium symporter
CUN60_08935	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CUN60_08950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUN60_08965	COG0756	dUTP diphosphatase activity
CUN60_08975	COG2814	Major facilitator Superfamily
CUN60_09000	COG0181	hydroxymethylbilane synthase activity
CUN60_09005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CUN60_09010	COG0686	Belongs to the AlaDH PNT family
CUN60_09020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CUN60_09030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CUN60_09040	COG0842	Transport permease protein
CUN60_09045	COG1131	(ABC) transporter
CUN60_09050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CUN60_09060	COG0477	Major facilitator Superfamily
CUN60_09075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CUN60_09080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CUN60_09095	COG0525	valine-tRNA ligase activity
CUN60_09100	COG2835	tetraacyldisaccharide 4'-kinase activity
CUN60_09105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CUN60_09120	COG3681	Belongs to the UPF0597 family
CUN60_09130	COG0519	Catalyzes the synthesis of GMP from XMP
CUN60_09135	COG0488	(ABC) transporter
CUN60_09140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CUN60_09145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CUN60_09145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CUN60_09160	COG1252	NADH dehydrogenase
CUN60_09170	COG2431	L-lysine efflux transmembrane transporter activity
CUN60_09180	COG0179	Fumarylacetoacetate (FAA) hydrolase
CUN60_09185	COG2814	Major facilitator Superfamily
CUN60_09195	COG0163	prenyltransferase activity
CUN60_09200	COG0205	6-phosphofructokinase activity
CUN60_09230	COG0583	DNA-binding transcription factor activity
CUN60_09240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CUN60_09250	COG2801	Transposase and inactivated derivatives
CUN60_09255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CUN60_09260	COG0792	nuclease activity
CUN60_09270	COG2823	Periplasmic or secreted lipoprotein
CUN60_09275	COG0501	Belongs to the peptidase M48B family
CUN60_09280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CUN60_09290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CUN60_09320	COG1505	serine-type exopeptidase activity
CUN60_09350	COG2096	Adenosyltransferase
CUN60_09360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CUN60_09370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CUN60_09375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CUN60_09380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CUN60_09390	COG0409	Hydrogenase expression formation protein
CUN60_09400	COG0714	Associated with various cellular activities
CUN60_09415	COG2304	oxidoreductase activity
CUN60_09465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CUN60_09485	COG1596	polysaccharide export
CUN60_09500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CUN60_09505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CUN60_09505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CUN60_09510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CUN60_09515	COG0586	Pfam SNARE associated Golgi protein
CUN60_09525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUN60_09530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUN60_09535	COG1862	Preprotein translocase
CUN60_09550	COG2801	Transposase and inactivated derivatives
CUN60_09575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CUN60_09620	COG4232	protein-disulfide reductase activity
CUN60_09625	COG2271	Major facilitator Superfamily
CUN60_09635	COG0776	regulation of translation
CUN60_09645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CUN60_09650	COG0084	hydrolase, TatD family'
CUN60_09655	COG0194	GDP metabolic process
CUN60_09660	COG1758	RNA polymerase activity
CUN60_09665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CUN60_09670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CUN60_09675	COG0750	zinc metalloprotease
CUN60_09690	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUN60_09695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CUN60_09700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUN60_09745	COG1464	Belongs to the NlpA lipoprotein family
CUN60_09750	COG0025	NhaP-type Na H and K H
CUN60_09785	COG0469	pyruvate kinase activity
CUN60_09800	COG1116	anion transmembrane transporter activity
CUN60_09825	COG0673	inositol 2-dehydrogenase activity
CUN60_09835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUN60_09845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CUN60_09860	COG0233	cytoplasmic translational termination
CUN60_09870	COG0575	Belongs to the CDS family
CUN60_09890	COG0501	Belongs to the peptidase M48B family
CUN60_09915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CUN60_09940	COG0531	amino acid
CUN60_09945	COG0659	secondary active sulfate transmembrane transporter activity
CUN60_09960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CUN60_09995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUN60_10050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CUN60_10060	COG0277	FAD linked oxidase domain protein
CUN60_10060	COG0247	lactate metabolic process
CUN60_10090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CUN60_10110	COG1464	Belongs to the NlpA lipoprotein family
CUN60_10125	COG1253	flavin adenine dinucleotide binding
CUN60_10135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUN60_10135	COG1263	PTS System
CUN60_10140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CUN60_10145	COG1285	pathogenesis
CUN60_10150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CUN60_10155	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CUN60_10160	COG2031	fatty acid transporter
CUN60_10175	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CUN60_10185	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CUN60_10195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CUN60_10215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUN60_10225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUN60_10225	COG4651	solute:proton antiporter activity
CUN60_10230	COG1234	tRNA 3'-trailer cleavage
CUN60_10235	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CUN60_10265	COG0483	inositol monophosphate 1-phosphatase activity
CUN60_10270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CUN60_10275	COG0009	L-threonylcarbamoyladenylate synthase
CUN60_10290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CUN60_10295	COG1671	Belongs to the UPF0178 family
CUN60_10320	COG0402	S-adenosylhomocysteine deaminase activity
CUN60_10325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUN60_10330	COG0583	DNA-binding transcription factor activity
CUN60_10345	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUN60_10360	COG0567	Dehydrogenase, E1 component
CUN60_10370	COG0372	Belongs to the citrate synthase family
CUN60_10375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CUN60_10380	COG1053	succinate dehydrogenase
CUN60_10405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CUN60_10425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CUN60_10440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CUN60_10445	COG0742	ribosomal rna small subunit methyltransferase
CUN60_10450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CUN60_10465	COG1137	ATPase activity
CUN60_10470	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CUN60_10480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CUN60_10485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CUN60_10485	COG0517	IMP dehydrogenase activity
CUN60_10520	COG1475	DNA binding
CUN60_10525	COG1192	Involved in chromosome partitioning
CUN60_10530	COG0357	Ribosomal RNA small subunit methyltransferase G
CUN60_10545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CUN60_10555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUN60_10560	COG0741	lytic transglycosylase activity
CUN60_10570	COG2860	membrane
CUN60_10585	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CUN60_10600	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CUN60_10620	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CUN60_10635	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CUN60_10660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CUN60_10665	COG1045	serine acetyltransferase
CUN60_10670	COG1280	lysine exporter protein (LysE YggA)
CUN60_10690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CUN60_10705	COG1388	LysM domain
CUN60_10705	COG4942	peptidase
CUN60_10715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CUN60_10720	COG0343	queuine tRNA-ribosyltransferase activity
CUN60_10730	COG0653	protein targeting
CUN60_10735	COG2267	carboxylic ester hydrolase activity
CUN60_10740	COG3781	membrane
CUN60_10790	COG0321	lipoyl(octanoyl) transferase activity
CUN60_10795	COG2921	Belongs to the UPF0250 family
CUN60_10800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CUN60_10815	COG1702	phosphate starvation-inducible protein PhoH
CUN60_10830	COG0359	binds to the 23S rRNA
CUN60_10840	COG0360	Binds together with S18 to 16S ribosomal RNA
CUN60_10850	COG1960	acyl-CoA dehydrogenase activity
CUN60_10855	COG1028	Short-chain dehydrogenase reductase Sdr
CUN60_10860	COG0318	PFAM AMP-dependent synthetase and ligase
CUN60_10865	COG0183	Belongs to the thiolase family
CUN60_10870	COG1024	Enoyl-CoA hydratase
CUN60_10870	COG1250	3-hydroxyacyl-CoA dehydrogenase
CUN60_10875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CUN60_10885	COG2855	membrane
CUN60_10890	COG1566	PFAM secretion protein HlyD family protein
CUN60_10970	COG4932	domain protein
CUN60_10970	COG5492	domain, Protein
CUN60_10975	COG0477	Major facilitator Superfamily
CUN60_11065	COG0583	DNA-binding transcription factor activity
CUN60_11075	COG0051	transcription antitermination factor activity, RNA binding
CUN60_11080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CUN60_11085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CUN60_11090	COG0049	tRNA binding
CUN60_11095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CUN60_11135	COG3104	oligopeptide transport
CUN60_11150	COG1012	belongs to the aldehyde dehydrogenase family
CUN60_11155	COG1011	Hydrolase
CUN60_11160	COG0203	ribosomal protein L17
CUN60_11165	COG0202	RNA polymerase activity
CUN60_11170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CUN60_11175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CUN60_11190	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CUN60_11195	COG0201	protein transport
CUN60_11200	COG0200	Binds to the 23S rRNA
CUN60_11205	COG1841	ribosomal large subunit assembly
CUN60_11210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CUN60_11215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CUN60_11220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CUN60_11225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CUN60_11235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CUN60_11240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CUN60_11245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CUN60_11250	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CUN60_11255	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CUN60_11270	COG2205	protein histidine kinase activity
CUN60_11275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CUN60_11280	COG0255	Belongs to the universal ribosomal protein uL29 family
CUN60_11295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CUN60_11300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CUN60_11305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CUN60_11310	COG0089	rRNA binding
CUN60_11320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CUN60_11325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUN60_11330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CUN60_11335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CUN60_11365	COG0785	Cytochrome C biogenesis protein
CUN60_11365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUN60_11380	COG1663	tetraacyldisaccharide 4'-kinase activity
CUN60_11395	COG0475	glutathione-regulated potassium exporter activity
CUN60_11400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUN60_11415	COG0460	homoserine dehydrogenase
CUN60_11415	COG0527	aspartate kinase activity
CUN60_11425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CUN60_11445	COG0174	glutamine synthetase
CUN60_11450	COG0791	NLP P60 protein
CUN60_11465	COG1136	(ABC) transporter
CUN60_11490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CUN60_11505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CUN60_11510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CUN60_11530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CUN60_11535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CUN60_11540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CUN60_11550	COG0316	Belongs to the HesB IscA family
CUN60_11555	COG0028	Belongs to the TPP enzyme family
CUN60_11570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUN60_11575	COG0028	Belongs to the TPP enzyme family
CUN60_11580	COG3527	Alpha-acetolactate decarboxylase
CUN60_11585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CUN60_11590	COG0052	Belongs to the universal ribosomal protein uS2 family
CUN60_11595	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CUN60_11600	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CUN60_11625	COG1121	(ABC) transporter
CUN60_11635	COG0523	cobalamin synthesis protein
CUN60_11645	COG2866	Carboxypeptidase
CUN60_11660	COG2884	Cell division ATP-binding protein ftsE
CUN60_11670	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CUN60_11695	COG0583	DNA-binding transcription factor activity
CUN60_11700	COG0583	DNA-binding transcription factor activity
CUN60_11725	COG0335	large ribosomal subunit rRNA binding
CUN60_11730	COG0336	Belongs to the RNA methyltransferase TrmD family
CUN60_11740	COG0228	four-way junction DNA binding
CUN60_11760	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CUN60_11770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUN60_11775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CUN60_11780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CUN60_11790	COG3028	Belongs to the UPF0307 family
CUN60_11795	COG0352	thiamine-phosphate diphosphorylase activity
CUN60_11795	COG0351	phosphomethylpyrimidine kinase
CUN60_11795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CUN60_11805	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CUN60_11810	COG0352	thiamine-phosphate diphosphorylase activity
CUN60_11860	COG1979	alcohol dehydrogenase
CUN60_11895	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CUN60_11915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CUN60_11920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUN60_11930	COG2226	methyltransferase
CUN60_11935	COG1040	competence protein
CUN60_11945	COG1879	ABC-type sugar transport system periplasmic component
CUN60_11950	COG1172	Belongs to the binding-protein-dependent transport system permease family
CUN60_11955	COG1129	ABC transporter
CUN60_11960	COG1869	D-ribose catabolic process
CUN60_11965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CUN60_11995	COG0012	GTP binding
CUN60_12050	COG0582	viral genome integration into host DNA
CUN60_12060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CUN60_12065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CUN60_12070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CUN60_12075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CUN60_12080	COG0196	riboflavin kinase activity
CUN60_12100	COG0210	DNA helicase
CUN60_12115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CUN60_12120	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CUN60_12125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CUN60_12160	COG2165	general secretion pathway protein
CUN60_12185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CUN60_12205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CUN60_12215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CUN60_12240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CUN60_12250	COG0367	asparagine synthase
CUN60_12260	COG0859	PFAM glycosyl transferase family 9
CUN60_12305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUN60_12310	COG2878	Part of a membrane complex involved in electron transport
CUN60_12320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CUN60_12360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CUN60_12365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CUN60_12370	COG0497	DNA recombination
CUN60_12375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CUN60_12380	COG0736	holo-[acyl-carrier-protein] synthase activity
CUN60_12385	COG1279	arginine transmembrane transporter activity
CUN60_12390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CUN60_12455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CUN60_12465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CUN60_12475	COG0222	ribosome binding
CUN60_12480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CUN60_12485	COG0081	regulation of translation
CUN60_12515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUN60_12520	COG0318	PFAM AMP-dependent synthetase and ligase
CUN60_12525	COG4783	chaperone-mediated protein folding
CUN60_12550	COG0237	dephospho-CoA kinase activity
CUN60_12555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CUN60_12565	COG1459	type II secretion system
CUN60_12570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CUN60_12575	COG4536	flavin adenine dinucleotide binding
CUN60_12585	COG0459	protein refolding
CUN60_12620	COG3437	response regulator, receiver
CUN60_12620	COG4999	Histidine kinase
CUN60_12620	COG2205	protein histidine kinase activity
CUN60_12620	COG3850	Histidine kinase
CUN60_12625	COG2205	protein histidine kinase activity
CUN60_12625	COG0784	Response regulator, receiver
CUN60_12625	COG5002	protein histidine kinase activity
CUN60_12640	COG1215	transferase activity, transferring glycosyl groups
CUN60_12660	COG0673	inositol 2-dehydrogenase activity
CUN60_12665	COG1534	Rna-binding protein
CUN60_12670	COG0531	amino acid
CUN60_12675	COG2890	protein-(glutamine-N5) methyltransferase activity
CUN60_12685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CUN60_12690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CUN60_12740	COG1028	Short-chain dehydrogenase reductase Sdr
CUN60_12745	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CUN60_12770	COG0367	asparagine synthase
CUN60_12785	COG0367	asparagine synthase
CUN60_12795	COG0500	methyltransferase
CUN60_12800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CUN60_12800	COG2813	Specifically methylates the guanine in position
CUN60_12805	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose