locus-tag class description aq_001 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) aq_005 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) aq_008 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) aq_009 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) aq_011 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) aq_012 ENOG41082UH One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) aq_013 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity aq_015 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) aq_016a ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) aq_017 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) aq_018 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) aq_020 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal aq_021 ENOG4105FF2 Type I DHQase aq_023 ENOG4105C8Y Acetylornithine aminotransferase aq_024 ENOG4105C6Y Udp-glucose 6-dehydrogenase aq_025 ENOG4105CNI cell division protein FtsW aq_027 ENOG4105BZU Histidine kinase aq_030 ENOG4105CVM Molybdenum cofactor synthesis domain protein aq_031 ENOG4105C8P )-transporter aq_035 ENOG4105BZU Histidine kinase aq_036 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) aq_038 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase aq_039 ENOG4105ECC imidazole-glycerol-phosphate dehydratase aq_041 ENOG4105VFF UPF0102 protein aq_044 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) aq_045 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) aq_046 ENOG4105CS7 Catalyzes the conversion of dihydroorotate to orotate aq_049 ENOG4108ZCD Transcriptional coactivator pterin dehydratase aq_052 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) aq_053 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) aq_054 ENOG4108WTY tRNA (Guanine-N(1)-)-methyltransferase aq_056 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) aq_057 ENOG4105PW4 Sugar fermentation stimulation protein homolog aq_058 ENOG41061D6 aq_061 ENOG4108RIR Molybdenum cofactor biosynthesis protein aq_062 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) aq_063 ENOG41083NI Binds together with S18 to 16S ribosomal RNA (By similarity) aq_064 ENOG41082Y9 Single-strand binding protein aq_064a ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) aq_064b ENOG41086UQ Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) aq_064c ENOG4108491 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) aq_065 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) aq_067 ENOG4105QAX Iron-sulfur aq_069 ENOG4108ZT0 50S ribosomal protein l17 aq_070 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) aq_072 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) aq_073 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) aq_074 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits aq_075a ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) aq_076 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) aq_078 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) aq_079 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) aq_080 ENOG41085S9 50S ribosomal protein l28 aq_081 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase aq_083 ENOG4105BZU Histidine kinase aq_085 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase aq_086 ENOG4105E0C molybdate abc transporter aq_091 ENOG4108JUB Transcriptional regulator aq_093 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family aq_094 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) aq_097 ENOG4107JPU aq_098 ENOG41085N6 Preprotein translocase subunit SecG aq_099 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) aq_1001 ENOG4105ER2 Ompa motb domain protein aq_1002 ENOG4105ER2 Ompa motb domain protein aq_1003 ENOG4108217 motA TolQ ExbB proton channel aq_1005 ENOG4105VF7 tolerance protein aq_1006 ENOG4105EYH Exonuclease aq_1008 ENOG4105C0B DNA polymerase III (alpha subunit) aq_101 ENOG4105C37 (CBS) domain aq_1013 ENOG4105EGS Mechanosensitive ion channel aq_1015 ENOG4105CFP Peptidase U32 aq_1019 ENOG4105C45 hydrogenase expression formation protein (HypE) aq_1021 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) aq_1023 ENOG4105DGU Histone deacetylase aq_1024 ENOG4108YV4 Universal stress protein aq_1026 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) aq_1029 ENOG4105V6R aq_103 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase aq_1030 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) aq_1031 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) aq_1033 ENOG4105EM7 Selenocysteine-specific translation elongation factor aq_1035 ENOG4108KS2 transglutaminase domain protein aq_1038 ENOG4105D5T phosphonate abc transporter aq_104 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) aq_1046 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein aq_1050 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) aq_1051 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) aq_1052 ENOG4105S6X Glycine cleavage aq_1053 ENOG4105C3J Cysteine desulfurase aq_1054 ENOG4105DIN metallophosphoesterase aq_1055 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) aq_1057 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) aq_1058 ENOG4108IG5 Transcriptional regulator aq_1059 ENOG4105DFG type I secretion outer membrane protein aq_1062 ENOG4105C0R drug resistance transporter emrb qaca subfamily aq_1065 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase aq_1067 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) aq_1068 ENOG4105C8N cysteinyl-tRNA synthetase aq_1071 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) aq_1073 ENOG4105PGM cation diffusion facilitator family transporter aq_1078 ENOG4108YSP acyltransferase 3 aq_1081 ENOG4107RIQ Sulfate adenylate transferase aq_1082 ENOG4105C0K Gdp-mannose 4,6-dehydratase aq_1088 ENOG4107RDJ Sulfotransferase aq_108a ENOG4105NZG Ferredoxin aq_108b ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) aq_109 ENOG4108YZA Nitrogen regulatory protein pii aq_1094 ENOG4105EY8 ABC transporter aq_1097 ENOG4108JJ6 Type I secretion system ATPase aq_1099 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) aq_1101 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) aq_1102 ENOG41067VY 50S ribosomal protein L32 aq_1103 ENOG4105KNH Nucleic acid-binding protein aq_1104 ENOG4105JF9 DNA polymerase III, delta aq_1105 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I aq_1108 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) aq_1109 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor aq_111 ENOG4105C5F glutamine synthetase aq_1111 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) aq_1115 ENOG4105BZU Histidine kinase aq_1117 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family aq_112 ENOG4105BZU Histidine kinase aq_1121 ENOG4108WPB aq_113 ENOG4108U9A aq_1130 ENOG4105E3B Multicopper oxidase aq_1134 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) aq_1138 ENOG4108YZG isomerase aq_1140 ENOG4105CDH Citrulline--aspartate ligase aq_1143 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) aq_1144 ENOG4105CRQ synthase (Component I) aq_1145 ENOG4108JB8 alcohol dehydrogenase aq_1151 ENOG4105BZU Histidine kinase aq_1152 ENOG4105CFH Aspartokinase aq_1154 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP aq_1155 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) aq_1156 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) aq_1159 ENOG4106K5Q Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity) aq_116 ENOG4108IEG Formate dehydrogenase Alpha subunit aq_1168 ENOG4105DDK oxidoreductase, beta subunit aq_1171a ENOG4105V1S Ferredoxin aq_1172 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain aq_1173 ENOG410902C phosphohistidine phosphatase, SixA aq_1174 ENOG4105K6T rare lipoprotein A aq_1176 ENOG41063VK aq_1177 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) aq_1178 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) aq_118 ENOG4105BZA Phosphoglycerate kinase aq_1180 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) aq_1182 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) aq_1182a ENOG41086ME flagellar hook-basal body complex aq_1183 ENOG4108ZC9 flagellar basal-body rod protein flgc aq_1184 ENOG41083MZ Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) aq_1189 ENOG4105CJN penicillin-binding protein aq_119 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) aq_1192a ENOG4105R8R Ferredoxin aq_1195 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) aq_1196 ENOG4105DDK oxidoreductase, beta subunit aq_1201 ENOG41067WS aq_1202 ENOG4105CRK lysyL-tRNA synthetase aq_1204 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) aq_1206 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) aq_1208 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) aq_1210 ENOG4105C4B ABC transporter, permease aq_1211 ENOG4106C81 type IV pilus assembly protein PilZ aq_1212 ENOG4105D7B Flagellar biosynthesis protein flha aq_1214 ENOG4105FZW flagellar biosynthesis regulator FlhF aq_1217 ENOG4107R21 site-determining protein aq_1218 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) aq_122 ENOG4105CUT histidyl-tRNA synthetase aq_1220 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) aq_1221 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) aq_1222 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) aq_1224 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) aq_1226 ENOG4105DZH s-adenosylmethionine synthetase (EC 2.5.1.6) aq_1229 ENOG4107RDB Major Facilitator aq_123 ENOG41085RT 30s ribosomal protein S16 aq_1231 ENOG4108KDI dmso reductase anchor subunit aq_1232 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein aq_1234 ENOG4105DB1 molybdopterin oxidoreductase aq_1237 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) aq_1240 ENOG410904N short-chain dehydrogenase reductase aq_1241 ENOG4105TH5 aq_1242 ENOG4105C98 muts2 protein aq_1245 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase aq_1248 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) aq_1249 ENOG4105KNE Phosphatidate cytidylyltransferase aq_124a ENOG4105VB6 UPF0109 protein aq_125 ENOG410666C aq_1250 ENOG4108V1U phospholipid-binding protein aq_1254 ENOG4105VIE preprotein translocase, subunit YajC aq_1255 ENOG4105CE1 Ferrous iron transport protein b aq_1256 ENOG4107EZ8 Inherit from NOG: Carbohydrate-selective porin OprB aq_1257 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) aq_1258 ENOG4105CJ2 (LipO)protein aq_1259 ENOG41079HR Phosphate-Selective Porin O and P aq_1262 ENOG4105ZAI aq_1264 ENOG4105J9Q aq_1265 ENOG4105D22 carbon starvation protein aq_1267 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) aq_1271 ENOG4107RAN Peptidase, M16 aq_1272 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) aq_1273 ENOG4108M79 outer membrane assembly lipoprotein YfiO aq_1275 ENOG4105C03 ribonuclease aq_1279 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) aq_128 ENOG4107QI1 Mate efflux family protein aq_1281 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) aq_1283 ENOG4105VN1 Heat shock protein aq_1285 ENOG4105D7Q type ii secretion system aq_1287 ENOG41064DK aq_1288 ENOG4105GVR general secretion pathway protein D aq_1290 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis aq_1292 ENOG4105Q33 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency aq_1293 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) aq_1300 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane aq_1303 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase aq_1303a ENOG4105VEQ Cold shock protein aq_1305 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) aq_1306 ENOG4105CMV Succinyl-CoA synthetase subunit beta aq_1308 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) aq_1309 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) aq_1310 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain aq_1312 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_1314 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_1315 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) aq_1317 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_1319 ENOG410839Q NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_132 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) aq_1321 ENOG4105C8S subunit m aq_1322 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_1323 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) aq_1324 ENOG4108UFN aq_1329 ENOG4105D06 uba thif-type nad fad binding protein aq_133 ENOG41082MB Involved in the transcription termination process (By similarity) aq_1331 ENOG4105ENT Efflux transporter rnd family, mfp subunit aq_1333 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) aq_1334 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) aq_1336 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein aq_1337 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) aq_1339 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) aq_1340 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation aq_1342 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) aq_1345 ENOG41087YS Phage shock protein A aq_135 ENOG4105K4T epimerase aq_1350 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) aq_1351 ENOG4105C9A Phoh family aq_1354 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) aq_1355 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) aq_1357 ENOG4105C4M (Ubiquinol oxidase) subunit I aq_1358 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii aq_1359 ENOG4108Z1Z gCN5-related N-acetyltransferase aq_136 ENOG4105CA0 peroxidase aq_1360 ENOG4105DFU Cell wall formation (By similarity) aq_1362 ENOG4105EE1 crotonyl-CoA reductase aq_1363 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein aq_1364 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) aq_1365 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) aq_1366 ENOG4108UB3 Thiamine monophosphate aq_1367 ENOG4108Y5D Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase aq_1369 ENOG4105HI1 aq_1370 ENOG4105K6T rare lipoprotein A aq_1372 ENOG4105CH7 arginosuccinase aq_1373 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) aq_1374 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) aq_1375 ENOG4107X8D NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_1377 ENOG4105DF2 NADH dehydrogenase subunit j aq_1378 ENOG4108373 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_138 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) aq_1382 ENOG4105C8S subunit m aq_1383 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_1386 ENOG4105D78 K07001 NTE family protein aq_139 ENOG4105DTN riboflavin biosynthesis protein ribF aq_1390 ENOG4105D2N Aldolase aq_1391 ENOG4105S9Q transposase (IS4 family) protein aq_1394 ENOG4107TRG DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) aq_1398 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) aq_1401 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) aq_1404 ENOG4105EZN Cobyrinic acid ac-diamide synthase aq_1407 ENOG4107QZ7 Cellulose synthase catalytic subunit aq_141 ENOG4107YU2 histidine triad (hIT) protein aq_1410 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) aq_1413 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) aq_1419 ENOG41083NF Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) aq_142 ENOG4105MPX aq_1420 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division aq_1421 ENOG4107XUC SirA family aq_1422 ENOG4105DCG PHP domain protein aq_1423 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) aq_1424 ENOG4105CSA Coproporphyrinogen iii oxidase aq_1426 ENOG41066BA aq_1427 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) aq_1428 ENOG4106GRT aq_1429 ENOG4105SYT Methylenetetrahydrofolate reductase aq_1434 ENOG4108ZUW Major pilin subunit aq_1436 ENOG41067CW aq_1442 ENOG4105BZU Histidine kinase aq_1444 ENOG4105NBF ammecr1 domain protein aq_1446 ENOG41060IT aq_145 ENOG4105DKP glycosyl transferase, family 9 aq_1450 ENOG4105C0H protease aq_1452 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) aq_1453 ENOG4108C5W FIST N domain aq_1455 ENOG4105BZU Histidine kinase aq_1457 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) aq_1458 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) aq_1464 ENOG4105FE9 pseudouridine synthase aq_1465 ENOG4106H45 aq_1466 ENOG41063NT aq_1467 ENOG4105C8B TIGR00159 family aq_1470 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase aq_1472 ENOG4105CDU Replicative dna helicase aq_1474 ENOG4107QHF type ii secretion system protein e aq_1478 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) aq_148 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) aq_1480 ENOG4108VTU Cdp-alcohol phosphatidyltransferase aq_1482 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) aq_1483 ENOG41082G8 outer membrane lipoprotein carrier protein LolA aq_1484a ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) aq_1485 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) aq_1489 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) aq_1490 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) aq_1493 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) aq_1494 ENOG41082UD thioesterase Superfamily protein aq_1498 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) aq_1499 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) aq_1502 ENOG4108X4A aq_1503 ENOG4107ZYR domain protein aq_1505 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) aq_1509 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component aq_1512 ENOG4108HMX isocitrate dehydrogenase (NADP) aq_1517 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase aq_152 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen aq_1520 ENOG4107QSA Oxaloacetate decarboxylase aq_1526 ENOG4107QRG dna polymerase iii aq_1527 ENOG4105MA4 psp1 domain protein aq_1528 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs aq_1530 ENOG4105CY3 ABC transporter, permease aq_1531 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) aq_1534 ENOG410758N aq_1535 ENOG4105DC7 peptidase M24 aq_1536 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase aq_1539 ENOG4105DD5 Flagellar motor switch protein aq_154 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) aq_1540 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) aq_1545 ENOG4108QU6 aq_1546 ENOG4105C2X Arabinose 5-phosphate isomerase aq_1547 ENOG4105F0N pyrophosphate phospho-hydrolase aq_1548 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) aq_155 ENOG4108KAG Cytochrome C oxidase, subunit I aq_1552 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH aq_1554 ENOG41061GT Aldolase aq_1556 ENOG4105C6T cysteine synthase aq_156 ENOG4108SJC Membrane aq_1560 ENOG4105CXV gliding motility protein aq_1563 ENOG4105BZ1 (ABC) transporter aq_1569 ENOG4107V5B Major Facilitator aq_157 ENOG41062GP outer membrane chaperone Skp (OmpH) aq_1575 ENOG4105CDY transcriptional regulatory protein aq_1578 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) aq_1579 ENOG4105FTC Lytic transglycosylase catalytic aq_1580 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) aq_1581 ENOG4106YDJ aq_1582 ENOG4108215 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) aq_1583 ENOG4106IMU aq_1585 ENOG4105D60 lipoprotein releasing system transmembrane protein aq_1587 ENOG4105MWA Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) aq_1588 ENOG4105SZ0 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) aq_1590 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) aq_1591 ENOG4105C5R Aminotransferase aq_1593 ENOG4105C5R Aminotransferase aq_1595 ENOG4108JIR Flagellum-specific ATP synthase aq_1598 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) aq_1599 ENOG41082J7 Rhodanese domain protein aq_1602 ENOG4107X8G Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) aq_1603 ENOG4105MS2 ribosomal subunit Interface protein aq_1606 ENOG4105CM2 brancheD-chain amino acid aminotransferase aq_1607 ENOG4105DHP deoxycytidine triphosphate deaminase aq_1609 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein aq_1610 ENOG4105W5Q DNA repair protein (RadC aq_1612 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) aq_1613 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) aq_1614 ENOG4107QSA Oxaloacetate decarboxylase aq_1618 ENOG4107ZP9 ComEC Rec2-related protein aq_162 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase aq_1620 ENOG4105CMV Succinyl-CoA synthetase subunit beta aq_1622 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha aq_1627 ENOG410615G aq_1628 ENOG4105C2M dna polymerase I aq_1629 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) aq_1630 ENOG4105SFS phosphoesterase RecJ domain protein aq_1632 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein aq_1634 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase aq_1636 ENOG4105C5T Phosphoribosyl pyrophosphate synthase aq_1638 ENOG4105DF9 Lipoate-protein, ligase aq_1639 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) aq_164 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family aq_1640 ENOG4105S9Q transposase (IS4 family) protein aq_1641 ENOG4105CG5 Glycosyl transferase (Group 1 aq_1641a ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) aq_1642 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) aq_1644 ENOG4108C6F 50S ribosomal protein L30 aq_1645 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) aq_1648 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) aq_1649 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) aq_165 ENOG4107XZW Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) aq_1651 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) aq_1651a ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) aq_1652 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits aq_1653 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) aq_1654 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) aq_1656 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) aq_1657 ENOG4108UR0 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) aq_1659 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) aq_166 ENOG4105II7 pyrroline-5-carboxylate reductase aq_1660 ENOG4108Z0R Transferase aq_1661 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase aq_1664 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase aq_1665 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) aq_1667 ENOG4105C22 threonyL-tRNA synthetase aq_167 ENOG41083W3 Multi-copper polyphenol oxidoreductase laccase aq_1671 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) aq_1672 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit aq_1677 ENOG4105C9M aspartyl-trna synthetase aq_1679 ENOG4107GFK fumarate aq_168 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) aq_1681 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase aq_1684 ENOG4105KZJ alginate biosynthesis protein Alg8 aq_169 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) aq_1693 ENOG4108UN4 phage SPO1 DNA polymerase-related protein aq_1694 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) aq_1695 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) aq_1695a ENOG4107SH3 glycosyl transferase, family 39 aq_170 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) aq_1707 ENOG4108R6K riboflavin synthase, subunit alpha aq_1708 ENOG4105CTQ phosphohexokinase aq_1710 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) aq_1711 ENOG4105DBV ornithine carbamoyltransferase aq_1713 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) aq_1714 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) aq_1716 ENOG4105CHR reductase aq_1717 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) aq_1717a ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) aq_1718 ENOG4108Z03 MAF-like protein aq_1719 ENOG4105VAV hemerythrin-like, metal-binding protein aq_172 ENOG4105CSM endonuclease III aq_1720 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY aq_1723 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) aq_1725 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) aq_1727 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) aq_1730 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) aq_1731 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase aq_1732 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) aq_1735 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) aq_1737 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase aq_1739 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) aq_1742 ENOG4106WTF Glycosyl transferase, family 2 aq_1744 ENOG4105CVJ phosphoglycerate mutase aq_1747 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) aq_175 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins aq_1751 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) aq_1754 ENOG4108JVH Protein of unknown function DUF43 aq_1757 ENOG4105M8K biopolymer transport protein aq_1758 ENOG4105C34 Pseudouridine synthase aq_1765 ENOG4105CV1 Transketolase (EC 2.2.1.1) aq_1767 ENOG41082E4 Binds directly to 16S ribosomal RNA (By similarity) aq_1768 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) aq_1769 ENOG4105CQB FAD linked oxidase domain protein aq_177 ENOG4108327 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) aq_1770 ENOG4107RXH tRNA synthetase valyl leucyl anticodon-binding aq_1772 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) aq_1773a ENOG4105K46 50S ribosomal protein l27 aq_1774 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) aq_1776 ENOG4108K4H aq_1777 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) aq_1780 ENOG4107GFK fumarate aq_1782 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) aq_1784 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) aq_1787 ENOG4105DK0 Indole-3-glycerol phosphate synthase aq_1789 ENOG4105CJR Integral membrane protein (MviN aq_179 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) aq_1790 ENOG4107NFR Fructose-1,6-bisphosphatase aq_1791 ENOG410639B aq_1792 ENOG4108JUA Transcriptional regulator aq_1794 ENOG4105D48 metallophosphoesterase aq_1796 ENOG4107SC1 transglycosylase aq_1799 ENOG4105KHC sulfurtransferase aq_1800 ENOG4105UUH Domain of unknown function DUF302 aq_1803 ENOG4105CGH 5'-nucleotidase aq_1806 ENOG4108XRS Monoheme cytochrome SoxX (Sulfur oxidation) aq_1807 ENOG4105QN4 diheme cytochrome aq_181 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) aq_1812 ENOG4105D6E homoserine dehydrogenase aq_1815 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) aq_1816 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) aq_1822 ENOG4106CKE aq_1824 ENOG41073JV aq_1825 ENOG4105BZU Histidine kinase aq_1827 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) aq_1827a ENOG4107PU6 Membrane aq_1832 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) aq_1834 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) aq_1836 ENOG4107QIK phosphoribosylformylglycinamidine synthase aq_1837 ENOG4108386 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) aq_1838 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) aq_1839 ENOG4105M15 transport protein ExbD aq_183a ENOG4106HQT Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) aq_184 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) aq_1840 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) aq_1842 ENOG41069WC aq_1845 ENOG4108UJG aq_185 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) aq_1850 ENOG41070QX aq_1851 ENOG4108ZP8 Acetolactate synthase small subunit aq_1853 ENOG4108Z4T Peptidase M50 aq_1854 ENOG41063VM cytochrome C, class I aq_1855 ENOG4105C6E dna polymerase iii aq_1856 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) aq_1857 ENOG4108YX9 iron--sulfur cluster insertion protein erpA aq_1859 ENOG4105BZE flagellar hook protein, FlgE aq_1860 ENOG4105X6C Flagellar basal body-associated protein FliL aq_1863 ENOG4105EYW Ion transport protein aq_1866 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) aq_1869 ENOG4105K4P CoA-binding domain protein aq_1870 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving aq_1873 ENOG4105FV0 aq_1875 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) aq_1877 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) aq_1878 ENOG4108UJD 30S ribosomal protein S9 aq_1879 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase aq_1882 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) aq_1884 ENOG4108URH decarboxylase aq_1887 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) aq_1888 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha aq_1889 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) aq_1890 ENOG4105C2N RNA methyltransferase TrmH family group 3 aq_1893 ENOG4105CM2 brancheD-chain amino acid aminotransferase aq_1894 ENOG4106D7Y Sporulation domain protein aq_1898 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) aq_1899 ENOG4105CKK Glycosyl transferase, family 2 aq_1899a ENOG41060IT aq_1903 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor aq_1907 ENOG4107YIW Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) aq_1908 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) aq_1909 ENOG4105S3U aq_1910 ENOG4105DCI Phosphohydrolase aq_1916 ENOG4105K63 Thioredoxin aq_1917 ENOG4105FGP Type IV pilus assembly aq_1919 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) aq_192 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) aq_1920 ENOG4105CN7 Flagellar biosynthetic protein FliP aq_1922 ENOG4106M32 3-dehydroquinate synthase aq_1924 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) aq_1928 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) aq_1930a ENOG4105WDJ 50S ribosomal protein L33 aq_1931 ENOG4107WP1 Participates in transcription elongation, termination and antitermination (By similarity) aq_1933 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) aq_1935 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) aq_1936 ENOG410823K 50S ribosomal protein L10 aq_1937 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) aq_1939 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) aq_194 ENOG4105UGY aq_1945 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) aq_1952 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) aq_1953 ENOG4105KSK (crossover) junction endodeoxyribonuclease aq_1954 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) aq_1955 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) aq_196 ENOG4107QYG anthranilate phosphoribosyltransferase aq_1960 ENOG4105DWF phosphomethylpyrimidine kinase aq_1961 ENOG4105D19 Role in flagellar biosynthesis (By similarity) aq_1962 ENOG4105VS8 Flagellar biosynthetic protein fliq aq_1963 ENOG4105DC1 bifunctional purine biosynthesis protein purh aq_1964 ENOG4105DZP Membrane-associated zinc metalloprotease aq_1965 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme aq_1967 ENOG4107U9H DNA polymerase aq_1968 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase aq_1969 ENOG4105CHM Aminotransferase aq_1971 ENOG4107QHF type ii secretion system protein e aq_1973 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) aq_1975 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) aq_1977 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) aq_1978 ENOG4106IBR Cupin domain aq_1979 ENOG4105CR5 Class II aldolase adducin family protein aq_1982 ENOG410611I TonB family aq_1983 ENOG4105ECY inositol monophosphatase aq_1985 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) aq_1986 ENOG4107S90 membrAne aq_1990 ENOG4105CVJ phosphoglycerate mutase aq_1991 ENOG4105D0M Protease HtpX homolog aq_1994 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) aq_1996 ENOG4105CEV competence damage-inducible protein aq_1997 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) aq_1998 ENOG4105I03 Flagellin aq_2001 ENOG410801E Flagellar hook-associated 2 domain-containing protein aq_2004 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) aq_2005 ENOG4108412 folate-binding protein ygfz aq_2007 ENOG4105CE9 30S ribosomal protein S2 aq_2009 ENOG4107YI3 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) aq_2013 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme aq_2014 ENOG4105D00 flagellar biosynthetic protein flhB aq_2015 ENOG4105C1Q protoporphyrinogen oxidase aq_2016 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) aq_2018 ENOG4105C8U phosphate abc transporter aq_2019 ENOG4105E2Z phosphate ABC transporter (Permease aq_202 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) aq_2020 ENOG4105QKM DsrE/DsrF-like family aq_2021 ENOG4105D1U peptidase U62 modulator of DNA gyrase aq_2023 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) aq_2027 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase aq_2030 ENOG4107W2M Sodium hydrogen exchanger aq_2032 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) aq_2035 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) aq_2036 ENOG4105JE6 integral membrane protein aq_2038 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) aq_2041 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) aq_2042 ENOG4105K9Q Binds to the 23S rRNA (By similarity) aq_2043 ENOG4105CRE cytochrome C aq_2045 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase aq_2046 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) aq_2051 ENOG4105KTQ flagellar basal-body rod protein aq_2053 ENOG4105CB5 ATP-dependent DNA helicase recG aq_2054 ENOG4105JVA Family of unknown function (DUF490) aq_2059 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) aq_206 ENOG4108IFG nitrite reductase, (NAD(P)H) aq_2060 ENOG4105F8V Hydrolase, tatD family aq_2066 ENOG4107T5V SNARE associated Golgi aq_2068 ENOG4105CAS nag kinase aq_2069 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control aq_207 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) aq_2071 ENOG4105DR4 Methyltransferase aq_2075 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) aq_2076 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase aq_2077 ENOG4105C8J )-transporter aq_2080 ENOG4105D07 Signal peptide peptidase, SppA aq_2084 ENOG4105CIH Imidazole acetol-phosphate transaminase aq_2085 ENOG4105TKY aq_209 ENOG4108MTB glycosyl transferase family aq_2090 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) aq_2094 ENOG4105CHM Aminotransferase aq_2095 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters aq_2096 ENOG4107ZS6 Flavodoxin aq_2099 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) aq_2101 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain aq_2102 ENOG410845P Methylates ribosomal protein L11 (By similarity) aq_2103 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) aq_2104 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) aq_2106 ENOG4107QN1 sodium solute aq_2108 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) aq_2109 ENOG4105D52 delta-aminolevulinic acid dehydratase aq_211 ENOG4107S2W Nitric oxide dioxygenase aq_2113 ENOG4105E4C Lytic transglycosylase catalytic aq_2114 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) aq_2115 ENOG4108PQP glycosyl transferase group 1 aq_2117 ENOG4105C8V SAICAR synthetase aq_2118 ENOG4105P7K Prokaryotic N-terminal methylation motif aq_2119 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) aq_212 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) aq_2120 ENOG4108JU5 Magnesium and cobalt efflux protein aq_2122 ENOG4108JQ7 (ABC) transporter aq_2124 ENOG4105D4P Coproporphyrinogen iii oxidase aq_2126 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) aq_2129 ENOG4105C09 Bile acid aq_213 ENOG4108YZA Nitrogen regulatory protein pii aq_2131 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) aq_2132 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) aq_2134 ENOG41063AQ aq_2135 ENOG4105C5X domain protein aq_2137 ENOG4108IJ6 ABC transporter aq_2139 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) aq_2141 ENOG4107RFA Glycyl-tRNA synthetase beta subunit aq_2142 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) aq_2144 ENOG4105HKT Pfam:Competence_A aq_2146 ENOG4105C7Z Conserved Protein aq_2150 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) aq_2151 ENOG4105CZX twitching motility protein aq_2153 ENOG4107RB4 Cytidine monophosphate kinase aq_2154 ENOG4108UKJ Cdp-alcohol phosphatidyltransferase aq_2155 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) aq_2157 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) aq_2163 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) aq_2168 ENOG4108P3C aq_2170 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) aq_2171 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase aq_2172 ENOG41069S8 aq_2174 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) aq_2175 ENOG4108R0F Bacterial cellulose synthase subunit aq_2177 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) aq_2178 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) aq_2179 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) aq_218 ENOG4108JUA Transcriptional regulator aq_2181 ENOG4108ZAF Molybdopterin aq_2183 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) aq_2185 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) aq_2186 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase aq_2190 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) aq_2191 ENOG4105BZ9 Cytochrome C oxidase, subunit I aq_2192 ENOG4107RQ2 Cytochrome c oxidase, subunit I aq_2195 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) aq_2199 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) aq_220 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) aq_2200 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) aq_2203 ENOG41060W7 aq_221 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) aq_226a ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) aq_230 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family aq_231 ENOG4105BZU Histidine kinase aq_232 ENOG4107S7U Sulfide dehydrogenase aq_235 ENOG4107S7U Sulfide dehydrogenase aq_236 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) aq_238 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) aq_239 ENOG4105EUJ GTP cyclohydrolase i aq_240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 aq_242 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) aq_243 ENOG4108M29 aq_244 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) aq_245 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit aq_247 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) aq_250 ENOG4105NHS Transcriptional regulator, TraR DksA family aq_251 ENOG4105GRF N-glycosylase DNA lyase aq_252 ENOG41065MP aq_253 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) aq_254 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) aq_255 ENOG41066RW aq_257 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) aq_259 ENOG4105CHV Transcription elongation factor NusA aq_260 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) aq_262 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) aq_263 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) aq_264 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) aq_265 ENOG4105BZU Histidine kinase aq_267 ENOG4108Z65 aq_268 ENOG410847I Transcriptional regulator, BadM Rrf2 family aq_269 ENOG4107XR7 (6-pyruvoyl tetrahydrobiopterin) synthase aq_270 ENOG4107XN1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) aq_271 ENOG4108KBH aq_272 ENOG41065BW aq_273 ENOG4105CHM Aminotransferase aq_274 ENOG4105DFA alanine racemase domain protein aq_278 ENOG4105CIZ coA-substrate-specific enzyme activase aq_281 ENOG4105PF9 Transcriptional regulator aq_282 ENOG4105CSM endonuclease III aq_284 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) aq_287 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) aq_291 ENOG4105C0P Mg chelatase subunit ChlI aq_296 ENOG4105D60 lipoprotein releasing system transmembrane protein aq_297 ENOG4107XPZ Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) aq_298 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) aq_301 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) aq_305 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) aq_308 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) aq_311 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) aq_313 ENOG4105E63 Pfam:DUF178 aq_314 ENOG4108ZAI phosphatidylglycerophosphatase a aq_316 ENOG4105BZU Histidine kinase aq_319 ENOG4105CK6 Two component transcriptional regulator (Winged helix family aq_322 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) aq_323 ENOG4107SET aldo keto reductase aq_324 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) aq_325 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) aq_326 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase aq_328 ENOG4108ZVP Domain of unknown function (DUF1931) aq_334 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) aq_337 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase aq_338 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) aq_342 ENOG4105DXN mazG family aq_343 ENOG4105D0U Arsenite-activated ATPase (ArsA) aq_346 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) aq_348 ENOG4107ZTA This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) aq_350 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) aq_351 ENOG4105C8T Leucyl-tRNA synthetase aq_355 ENOG4105CY3 ABC transporter, permease aq_356 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) aq_358 ENOG4105DVT helicase aq_359 ENOG4105V2A permease YjgP YjgQ family protein aq_360 ENOG4105CP7 Triose-phosphate isomerase aq_363 ENOG4105RRV Inherit from COG: copper resistance aq_364 ENOG4105KME endoribonuclease L-psp aq_365 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) aq_367 ENOG4105BZU Histidine kinase aq_369 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) aq_371 ENOG4105DTT CRISPR-associated helicase, cas3 aq_372 ENOG4108QCZ crispr-associated cxxc_cxxc protein cst1 aq_376 ENOG4106C8N aq_377 ENOG4108RBV CRISPR-associated protein, Csx3 family aq_388 ENOG4106DVI aq_389 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase aq_402 ENOG4105PHD The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) aq_404 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) aq_407 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B aq_409 ENOG4105CXT aspartate transcarbamylase aq_410 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain aq_411 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate aq_413 ENOG4108IUZ ABC transporter aq_416 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs aq_417 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) aq_418 ENOG4108VAU general secretion pathway protein G aq_420 ENOG41065IR aq_422 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) aq_428 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) aq_429 ENOG4105BZU Histidine kinase aq_433 ENOG41082NI Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ aq_434 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) aq_436 ENOG4105WCJ ec 1.1.1.193 aq_438 ENOG41080XP Cbs domain aq_445 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) aq_447 ENOG4105KT7 mgtC SapB transporter aq_448 ENOG41074UN Uncharacterized ACR, COG1993 aq_449 ENOG4107N47 CrcB-like protein aq_450 ENOG4105KJJ Uncharacterized ACR, COG1993 aq_453 ENOG4106HR4 ribonuclease bn aq_454 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein aq_458 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen aq_460 ENOG4108TTH aq_461 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) aq_474 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) aq_476 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) aq_478 ENOG4105D58 Diguanylate phosphodiesterase aq_479 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) aq_484 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) aq_488 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) aq_490 ENOG4105IJJ transcriptional regulator, crp fnr family aq_493 ENOG4107KIA Virulence factor Mce family protein aq_495 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen aq_496 ENOG4105CSM endonuclease III aq_497 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase aq_499 ENOG4105FA0 parb-like partition protein aq_500 ENOG4105C3M thioredoxin reductase aq_507 ENOG41060A7 DNA polymerase beta domain protein region aq_510 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) aq_511 ENOG4105D4A Cell wall formation (By similarity) aq_515 ENOG4108TJN glycosyl transferase group 1 aq_516 ENOG4105E2K Glycosyl transferase (Group 1 aq_518 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase aq_520 ENOG4105D4A Cell wall formation (By similarity) aq_521 ENOG4105CPF Cell wall formation (By similarity) aq_523 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) aq_525 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) aq_527 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) aq_528 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase aq_533 ENOG4105DR4 Methyltransferase aq_538 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) aq_539 ENOG41061WW permease YjgP YjgQ family protein aq_540 ENOG41081FY multiple antibiotic resistance (MarC)-related aq_542 ENOG4105E3H phosphoglycerate mutase aq_544 ENOG4108UGV hypoxanthine phosphoribosyltransferase aq_545 ENOG4106PBM aq_547 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) aq_548 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) aq_549 ENOG4105DDQ anthranilate synthase aq_551 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) aq_552 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) aq_553 ENOG4105E33 succinate dehydrogenase aq_554 ENOG4105I08 Pseudouridine synthase aq_556 ENOG4105CJN penicillin-binding protein aq_557 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) aq_558 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) aq_561 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) aq_563 ENOG4105BZU Histidine kinase aq_565 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) aq_568 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) aq_573 ENOG4107QIZ NADH dehydrogenase aq_574 ENOG4105GKE subunit e aq_576 ENOG4105D9P serine threonine protein kinase aq_579 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) aq_581 ENOG41065ZZ aq_582 ENOG4105CRQ synthase (Component I) aq_587 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) aq_589 ENOG4105CJT Mannose-1-phosphate guanylyltransferase aq_591 ENOG4107FKW Domain of unknown function (DUF309) aq_594 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) aq_597 ENOG4105C83 adenylosuccinate lyase aq_604 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) aq_607 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) aq_609 ENOG4105C3G gtp-binding protein aq_613 ENOG4105C1J atp-dependent rna helicase aq_615 ENOG4105GB4 17 kDa surface antigen aq_618 ENOG4107R7Y intracellular protease Pfpi family aq_620 ENOG4105FDK ABC transporter aq_621 ENOG4105CC5 ABC transporter aq_624 ENOG4108JQC penicillin-binding protein 1A aq_626 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) aq_629 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) aq_632 ENOG4105N5T Radical SAM Protein aq_633 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) aq_640 ENOG4107VZ4 thymidylate synthase aq_642 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP aq_648 ENOG4105DVY radical SAM domain protein aq_651 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) aq_652 ENOG4108K5P (LipO)protein aq_653 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) aq_655 ENOG4105E33 succinate dehydrogenase aq_657 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) aq_667 ENOG4108USZ hydrogenase aq_668 ENOG4106IF5 Hydrogenase-1 expression protein HyaE aq_673 ENOG41081GI Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) aq_674 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) aq_676 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) aq_678 ENOG4105UCM aq_679 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) aq_682 ENOG4105D0U Arsenite-activated ATPase (ArsA) aq_684 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) aq_685 ENOG4108UXE Protein tyrosine phosphatase aq_686 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) aq_689 ENOG4105BZU Histidine kinase aq_691 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) aq_692 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) aq_693 ENOG4108E5V Phosphate-Selective Porin O and P aq_698 ENOG4105ENT Efflux transporter rnd family, mfp subunit aq_701 ENOG4105WPN DNA integration recombination invertion protein aq_702 ENOG4105KNI merR family transcriptional Regulator aq_703 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) aq_705 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) aq_706 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) aq_707 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) aq_711 ENOG4107F4A aq_712 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) aq_713 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) aq_715 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) aq_717 ENOG4107R76 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) aq_721 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) aq_722 ENOG4107R91 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) aq_723 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) aq_727 ENOG4105C5I Dehydrogenase aq_728 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) aq_731 ENOG4107QIV Cytochrome c biogenesis protein aq_732 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) aq_734 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) aq_735 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) aq_736 ENOG4107QN2 dihydrolipoyl dehydrogenase aq_737 ENOG4105D1F ATP-binding protein aq_739 ENOG4107QI6 Cysteine desulfurase aq_740 ENOG4105F4G Membrane aq_742 ENOG4107QNG Phosphoribosylglycinamide synthetase aq_745 ENOG4105CZX twitching motility protein aq_748 ENOG4105CTB Polyprenyl synthetase aq_749 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) aq_750 ENOG4107VCH Bifunctional phosphoglucose phosphomannose isomerase aq_755 ENOG4105JVV aq_756 ENOG4108RMN UPF0128 protein aq_757 ENOG41079VI aq_758 ENOG4106VK0 aq_759 ENOG4106Z6D Molecular chaperone capable of stabilizing a range of proteins (By similarity) aq_761 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) aq_763 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) aq_765 ENOG4107G9V glycosyl transferase, family 39 aq_768 ENOG4105M7V 2'-5' rna ligase aq_769 ENOG4105CXB phosphoribosylaminoimidazole synthetase aq_771 ENOG4105DSJ YicC domain protein aq_773 ENOG4105DX0 Hemolysin A aq_775 ENOG4105HHA aminodeoxychorismate lyase aq_777 ENOG4108IYU L-aspartate oxidase aq_778 ENOG4105CHW UPF0052 protein aq_782 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) aq_786 ENOG4105BZS acriflavin resistance protein aq_789 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) aq_792a ENOG41085CK 50S ribosomal protein L35 aq_793 ENOG4105C4R Atp-dependent dna helicase aq_796 ENOG41067KE aq_797 ENOG4105CN1 protease aq_801 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) aq_805 ENOG4106BF9 aq_806 ENOG4105CD3 dihydroorotase aq_812 ENOG4105D64 Mechanosensitive ion channel aq_813 ENOG41083S1 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) aq_815 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase aq_816 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase aq_819 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) aq_821 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) aq_831 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) aq_832 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) aq_833 ENOG4107ESN Flagella basal body P-ring formation protein flgA aq_834 ENOG4105CGA flagellar basal-body rod protein FlgG aq_835 ENOG4107QZF nitrite reductase NADPH large subunit aq_837 ENOG4105C01 Dihydroxy-acid dehydratase aq_841 ENOG4108K3F N(2),N(2)-dimethylguanosine tRNA methyltransferase aq_843 ENOG4105K8N protein family UPF0079, ATPase aq_844 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) aq_845 ENOG4105DFF Rod shape-determining protein mreb aq_849 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) aq_851 ENOG4105D7N magnesium and cobalt transport protein CorA aq_852 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) aq_855 ENOG4107YZX Universal stress protein aq_857 ENOG4108V3E phosphoribosylglycinamide formyltransferase aq_858 ENOG4105D3R alkyl hydroperoxide reductase aq_863 ENOG4105EVH UPF0753 protein aq_867a ENOG41085TX 30S ribosomal protein S21 aq_869 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase aq_871 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) aq_873 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) aq_876 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) aq_878 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) aq_880 ENOG4108T9Q UPF0278 protein aq_881 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) aq_886 ENOG4106K5Q Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity) aq_890 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein aq_892 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase aq_894 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) aq_895 ENOG4105EAH synthase aq_896 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) aq_898 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) aq_901 ENOG4105E2X shikimate dehydrogenase aq_903 ENOG4108Z6B deaminase aq_905 ENOG4105ES5 Histidine kinase aq_906 ENOG4108UTW Plays a role in the regulation of phosphate uptake aq_908 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) aq_909 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) aq_910 ENOG4106CVF DNA replication protein aq_914 ENOG41075BH aq_915 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) aq_916 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) aq_917 ENOG4105FQT aq_919 ENOG4106SXB aq_919a ENOG4105Q81 Ferredoxin aq_920 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) aq_923 ENOG4105C75 arginyL-tRNA synthetase aq_924 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) aq_928 ENOG4105EW6 flavin reductase domain protein, FMN-binding aq_931 ENOG4107ZTM Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) aq_932 ENOG41083X2 DNA polymerase III, epsilon subunit aq_935 ENOG4105MCV aq_936 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) aq_940 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) aq_944 ENOG4105RQ5 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) aq_945 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit aq_946 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) aq_948 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) aq_951 ENOG4105CQC Prephenate dehydratase aq_952 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) aq_953 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) aq_955 ENOG4105C3F Signal peptidase i aq_957 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) aq_958 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase aq_959 ENOG4105C4K Nad synthetase aq_960 ENOG4105DPX Hydrogenase, large subunit aq_965 ENOG4105E3S small subunit aq_967 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) aq_968 ENOG4105DJV ribulose-phosphate 3-epimerase aq_969 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) aq_970 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) aq_973 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) aq_975 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) aq_980 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) aq_983 ENOG4108ZBT Inosine-uridine preferring nucleoside hydrolase aq_987 ENOG4108UVJ appr-1-p processing domain protein aq_992 ENOG4105C31 Tryptophanyl-tRNA synthetase aq_996 ENOG4105CFG Acts as a chaperone (By similarity) aq_999 ENOG4105CEY Amp-dependent synthetase and ligase aq_aa35 ENOG4107SKI cobyrinic Acid a,c-diamide synthase aq_aa40 ENOG4105S9Q transposase (IS4 family) protein aq_t20 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation aq_t21 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation