locus-tag	class	description
KNN14_00025	COG0668	transmembrane transport
KNN14_00030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KNN14_00035	COG0424	maF-like protein
KNN14_00040	COG0107	imidazoleglycerol-phosphate synthase activity
KNN14_00060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KNN14_00065	COG0616	signal peptide processing
KNN14_00070	COG1355	regulation of microtubule-based process
KNN14_00075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KNN14_00085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KNN14_00090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KNN14_00090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KNN14_00095	COG2389	metal-binding protein
KNN14_00105	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN14_00125	COG1144	Oxidoreductase
KNN14_00130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KNN14_00130	COG2050	protein possibly involved in aromatic compounds catabolism
KNN14_00135	COG3706	GGDEF domain
KNN14_00145	COG1136	(ABC) transporter
KNN14_00150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KNN14_00155	COG2890	protein-(glutamine-N5) methyltransferase activity
KNN14_00160	COG4536	flavin adenine dinucleotide binding
KNN14_00165	COG2003	Belongs to the UPF0758 family
KNN14_00170	COG1040	competence protein
KNN14_00175	COG0436	Aminotransferase
KNN14_00190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KNN14_00195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KNN14_00200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KNN14_00210	COG0457	Tetratricopeptide repeat
KNN14_00250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KNN14_00255	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KNN14_00260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KNN14_00270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KNN14_00275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KNN14_00280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KNN14_00285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KNN14_00290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KNN14_00295	COG0089	rRNA binding
KNN14_00300	COG0088	Forms part of the polypeptide exit tunnel
KNN14_00305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KNN14_00310	COG0051	transcription antitermination factor activity, RNA binding
KNN14_00315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KNN14_00320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KNN14_00325	COG0049	tRNA binding
KNN14_00330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KNN14_00335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KNN14_00340	COG0085	RNA polymerase activity
KNN14_00345	COG0222	ribosome binding
KNN14_00350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KNN14_00355	COG0081	regulation of translation
KNN14_00360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KNN14_00365	COG0250	Participates in transcription elongation, termination and antitermination
KNN14_00380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KNN14_00385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KNN14_00415	COG1242	4 iron, 4 sulfur cluster binding
KNN14_00420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KNN14_00425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KNN14_00430	COG0287	Prephenate dehydrogenase
KNN14_00455	COG2010	Cytochrome c
KNN14_00465	COG3439	Domain of unknown function DUF302
KNN14_00470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KNN14_00490	COG0728	peptidoglycan biosynthetic process
KNN14_00495	COG0268	Binds directly to 16S ribosomal RNA
KNN14_00510	COG1561	YicC-like family, N-terminal region
KNN14_00515	COG1199	ATP-dependent helicase activity
KNN14_00520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KNN14_00530	COG0505	Belongs to the CarA family
KNN14_00540	COG1966	Carbon starvation protein
KNN14_00550	COG0779	Required for maturation of 30S ribosomal subunits
KNN14_00555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KNN14_00555	COG0195	Participates in both transcription termination and antitermination
KNN14_00560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KNN14_00570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KNN14_00575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KNN14_00575	COG1372	Participates in initiation and elongation during chromosome replication
KNN14_00580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KNN14_00585	COG4581	dead DEAH box helicase
KNN14_00595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KNN14_00600	COG4654	Cytochrome c, class I
KNN14_00610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KNN14_00615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KNN14_00635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KNN14_00640	COG1993	acr, cog1993
KNN14_00645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KNN14_00660	COG4641	Protein conserved in bacteria
KNN14_00670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KNN14_00685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KNN14_00690	COG5002	protein histidine kinase activity
KNN14_00695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KNN14_00695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KNN14_00705	COG1132	(ABC) transporter
KNN14_00715	COG2361	Protein of unknown function DUF86
KNN14_00725	COG0302	gtp cyclohydrolase
KNN14_00735	COG0316	Belongs to the HesB IscA family
KNN14_00745	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KNN14_00750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KNN14_00755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KNN14_00770	COG0592	DNA-directed DNA polymerase activity
KNN14_00775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KNN14_00780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KNN14_00795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KNN14_00805	COG1522	sequence-specific DNA binding
KNN14_00810	COG0602	queuosine metabolic process
KNN14_00815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KNN14_00825	COG0535	radical SAM domain protein
KNN14_00850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN14_00870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KNN14_00885	COG1131	(ABC) transporter
KNN14_00905	COG4263	nitrous-oxide reductase activity
KNN14_00925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN14_00930	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
KNN14_00930	COG3261	NADH dehydrogenase
KNN14_00935	COG0651	ATP synthesis coupled electron transport
KNN14_00950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KNN14_00960	COG2204	response regulator
KNN14_00965	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KNN14_00980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KNN14_00985	COG2046	Belongs to the sulfate adenylyltransferase family
KNN14_00990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KNN14_01055	COG0650	Formate hydrogenlyase subunit 4
KNN14_01060	COG0651	ATP synthesis coupled electron transport
KNN14_01065	COG0651	ATP synthesis coupled electron transport
KNN14_01075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KNN14_01090	COG4942	peptidase
KNN14_01120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KNN14_01125	COG0045	succinate-CoA ligase (ADP-forming) activity
KNN14_01130	COG0018	arginyl-trna synthetase
KNN14_01135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KNN14_01140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN14_01155	COG0131	Imidazoleglycerol-phosphate dehydratase
KNN14_01160	COG1466	dna polymerase III delta subunit
KNN14_01170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KNN14_01175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KNN14_01190	COG0163	prenyltransferase activity
KNN14_01195	COG0439	Biotin carboxylase
KNN14_01205	COG1774	PSP1 C-terminal conserved region
KNN14_01215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KNN14_01220	COG3300	MHYT domain
KNN14_01220	COG5001	Diguanylate cyclase
KNN14_01225	COG0493	'glutamate synthase
KNN14_01235	COG0859	PFAM glycosyl transferase family 9
KNN14_01240	COG0772	Belongs to the SEDS family
KNN14_01250	COG0850	regulation of cytokinetic process
KNN14_01255	COG2894	cell division
KNN14_01260	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KNN14_01280	COG0385	Bile acid
KNN14_01285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KNN14_01300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KNN14_01320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KNN14_01325	COG0709	Synthesizes selenophosphate from selenide and ATP
KNN14_01330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KNN14_01345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN14_01350	COG0706	membrane insertase activity
KNN14_01355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KNN14_01365	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KNN14_01370	COG0356	it plays a direct role in the translocation of protons across the membrane
KNN14_01375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KNN14_01390	COG0003	Pfam Anion-transporting ATPase
KNN14_01405	COG0165	Argininosuccinate lyase
KNN14_01415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN14_01420	COG0543	2 iron, 2 sulfur cluster binding
KNN14_01425	COG0307	riboflavin synthase, alpha
KNN14_01430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KNN14_01435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KNN14_01440	COG0359	binds to the 23S rRNA
KNN14_01445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KNN14_01450	COG0629	single-stranded DNA binding
KNN14_01455	COG0360	Binds together with S18 to 16S ribosomal RNA
KNN14_01460	COG0129	dihydroxy-acid dehydratase activity
KNN14_01470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KNN14_01475	COG0649	NAD binding
KNN14_01475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN14_01480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN14_01485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN14_01490	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
KNN14_01500	COG0513	Belongs to the DEAD box helicase family
KNN14_01505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KNN14_01520	COG0776	regulation of translation
KNN14_01525	COG0644	oxidoreductase
KNN14_01550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KNN14_01555	COG0606	chelatase, subunit chli
KNN14_01560	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KNN14_01565	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KNN14_01590	COG1580	Controls the rotational direction of flagella during chemotaxis
KNN14_01600	COG1338	Plays a role in the flagellum-specific transport system
KNN14_01605	COG1987	bacterial-type flagellum assembly
KNN14_01610	COG1684	flagellar biosynthetic protein fliR
KNN14_01615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KNN14_01630	COG2154	pterin-4-alpha-carbinolamine dehydratase
KNN14_01645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KNN14_01650	COG4752	Belongs to the RNA methyltransferase TrmD family
KNN14_01655	COG3158	transport of potassium into the cell
KNN14_01660	COG0134	indole-3-glycerol-phosphate synthase activity
KNN14_01665	COG0425	Belongs to the sulfur carrier protein TusA family
KNN14_01680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KNN14_01685	COG1547	Domain of unknown function (DUF309)
KNN14_01690	COG1078	dGTPase activity
KNN14_01700	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KNN14_01705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KNN14_01710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KNN14_01750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KNN14_01765	COG0084	hydrolase, TatD family'
KNN14_01790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KNN14_01800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KNN14_01805	COG1335	isochorismatase
KNN14_01810	COG1489	DNA binding
KNN14_01815	COG0714	Associated with various cellular activities
KNN14_01825	COG0436	Aminotransferase
KNN14_01845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN14_01850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KNN14_01850	COG1565	acr, cog1565
KNN14_01880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KNN14_01885	COG0569	domain protein
KNN14_01895	COG1136	(ABC) transporter
KNN14_01895	COG0577	efflux transmembrane transporter activity
KNN14_01900	COG1136	(ABC) transporter
KNN14_01905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KNN14_01920	COG1458	PINc domain ribonuclease
KNN14_01935	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KNN14_01940	COG0052	Belongs to the universal ribosomal protein uS2 family
KNN14_01945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KNN14_01950	COG0528	UMP kinase activity
KNN14_01955	COG0233	cytoplasmic translational termination
KNN14_01960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KNN14_01965	COG0805	protein transport
KNN14_01970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN14_01975	COG0167	dihydroorotate dehydrogenase activity
KNN14_01985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KNN14_02000	COG0425	Belongs to the sulfur carrier protein TusA family
KNN14_02005	COG0482	sulfurtransferase activity
KNN14_02010	COG0822	iron-sulfur transferase activity
KNN14_02025	COG1830	Aldolase
KNN14_02030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KNN14_02035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KNN14_02040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KNN14_02050	COG0492	ferredoxin-NADP+ reductase activity
KNN14_02075	COG0444	Belongs to the ABC transporter superfamily
KNN14_02095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KNN14_02100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KNN14_02110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KNN14_02125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KNN14_02140	COG0527	aspartate kinase activity
KNN14_02145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KNN14_02145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KNN14_02150	COG0792	nuclease activity
KNN14_02165	COG0126	phosphoglycerate kinase activity
KNN14_02170	COG0483	inositol monophosphate 1-phosphatase activity
KNN14_02175	COG0589	response to stress
KNN14_02185	COG0795	lipopolysaccharide-transporting ATPase activity
KNN14_02210	COG1028	Short-chain dehydrogenase reductase Sdr
KNN14_02215	COG5002	protein histidine kinase activity
KNN14_02215	COG5001	Diguanylate cyclase
KNN14_02220	COG4478	integral membrane protein
KNN14_02240	COG0402	S-adenosylhomocysteine deaminase activity
KNN14_02250	COG0772	Belongs to the SEDS family
KNN14_02255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KNN14_02280	COG3547	Transposase (IS116 IS110 IS902 family)
KNN14_02285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KNN14_02290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNN14_02300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KNN14_02305	COG0446	pyridine nucleotide-disulphide oxidoreductase
KNN14_02320	COG0028	Belongs to the TPP enzyme family
KNN14_02325	COG0440	acetolactate synthase activity
KNN14_02330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KNN14_02335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KNN14_02340	COG3706	GGDEF domain
KNN14_02345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KNN14_02350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KNN14_02355	COG0047	phosphoribosylformylglycinamidine synthase activity
KNN14_02360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KNN14_02370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNN14_02380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KNN14_02385	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KNN14_02390	COG1546	Belongs to the CinA family
KNN14_02390	COG1058	Belongs to the CinA family
KNN14_02410	COG1749	Flagellar hook protein flgE
KNN14_02415	COG0156	8-amino-7-oxononanoate synthase activity
KNN14_02435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KNN14_02445	COG0736	holo-[acyl-carrier-protein] synthase activity
KNN14_02450	COG0351	phosphomethylpyrimidine kinase
KNN14_02455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KNN14_02460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KNN14_02465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KNN14_02470	COG3108	Peptidase M15
KNN14_02475	COG2989	Protein conserved in bacteria
KNN14_02485	COG0443	Heat shock 70 kDa protein
KNN14_02490	COG2703	oxygen carrier activity
KNN14_02520	COG0142	geranyltranstransferase activity
KNN14_02575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KNN14_02580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KNN14_02585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KNN14_02595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNN14_02600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KNN14_02610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KNN14_02615	COG1465	3-dehydroquinate synthase
KNN14_02620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KNN14_02635	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KNN14_02640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KNN14_02645	COG0243	molybdopterin cofactor binding
KNN14_02660	COG0437	4 iron, 4 sulfur cluster binding
KNN14_02665	COG0495	leucyl-tRNA aminoacylation
KNN14_02685	COG1730	sister chromatid segregation
KNN14_02695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KNN14_02700	COG1028	Short-chain dehydrogenase reductase Sdr
KNN14_02705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KNN14_02720	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KNN14_02725	COG1157	protein secretion by the type III secretion system
KNN14_02735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KNN14_02745	COG0438	transferase activity, transferring glycosyl groups
KNN14_02750	COG0012	GTP binding
KNN14_02765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KNN14_02775	COG1196	nuclear chromosome segregation
KNN14_02780	COG0542	response to heat
KNN14_02785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KNN14_02800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KNN14_02805	COG0235	Class ii aldolase
KNN14_02830	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KNN14_02835	COG0352	thiamine-phosphate diphosphorylase activity
KNN14_02840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KNN14_02845	COG0312	modulator of DNA gyrase
KNN14_02850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KNN14_02855	COG0511	ligase activity, forming carbon-carbon bonds
KNN14_02865	COG0159	tryptophan synthase activity
KNN14_02870	COG0552	protein localization to endoplasmic reticulum
KNN14_02870	COG0457	Tetratricopeptide repeat
KNN14_02875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KNN14_02880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KNN14_02885	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KNN14_02895	COG3118	belongs to the thioredoxin family
KNN14_02920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KNN14_02925	COG0300	oxidoreductase activity
KNN14_02955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN14_02965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KNN14_02975	COG0726	polysaccharide deacetylase
KNN14_02995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KNN14_03010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KNN14_03015	COG0124	histidyl-tRNA synthetase
KNN14_03025	COG0745	RESPONSE REGULATOR receiver
KNN14_03030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KNN14_03035	COG0531	amino acid
KNN14_03045	COG0544	peptidyl-prolyl cis-trans isomerase activity
KNN14_03050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KNN14_03055	COG0284	orotidine-5'-phosphate decarboxylase activity
KNN14_03060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KNN14_03065	COG0785	Cytochrome C biogenesis protein
KNN14_03070	COG0495	leucyl-tRNA aminoacylation
KNN14_03085	COG0674	pyruvate-flavodoxin oxidoreductase activity
KNN14_03090	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN14_03100	COG1144	Oxidoreductase
KNN14_03125	COG0425	Belongs to the sulfur carrier protein TusA family
KNN14_03130	COG2210	Belongs to the sulfur carrier protein TusA family
KNN14_03170	COG0509	glycine decarboxylation via glycine cleavage system
KNN14_03185	COG0509	glycine decarboxylation via glycine cleavage system
KNN14_03195	COG2885	chlorophyll binding
KNN14_03220	COG0717	Belongs to the dCTP deaminase family
KNN14_03245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KNN14_03250	COG0009	L-threonylcarbamoyladenylate synthase
KNN14_03255	COG0653	protein targeting
KNN14_03260	COG1918	ferrous iron import across plasma membrane
KNN14_03260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KNN14_03275	COG2257	FlhB HrpN YscU SpaS Family
KNN14_03285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KNN14_03295	COG0802	atpase or kinase
KNN14_03305	COG0406	alpha-ribazole phosphatase activity
KNN14_03310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN14_03315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KNN14_03320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KNN14_03325	COG1612	heme a metabolic process
KNN14_03330	COG0109	protoheme IX farnesyltransferase activity
KNN14_03335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN14_03340	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KNN14_03345	COG0298	carbon dioxide binding
KNN14_03350	COG0409	Hydrogenase expression formation protein
KNN14_03355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KNN14_03355	COG1024	Enoyl-CoA hydratase
KNN14_03365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KNN14_03370	COG1077	Cell shape determining protein MreB Mrl
KNN14_03385	COG0768	penicillin binding
KNN14_03390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KNN14_03395	COG0538	isocitrate dehydrogenase activity
KNN14_03415	COG4796	Type ii and iii secretion system protein
KNN14_03435	COG4972	Pilus assembly protein
KNN14_03440	COG1872	DUF167
KNN14_03450	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KNN14_03465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KNN14_03480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KNN14_03485	COG0039	L-malate dehydrogenase activity
KNN14_03505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KNN14_03515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KNN14_03535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KNN14_03540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KNN14_03545	COG0793	Belongs to the peptidase S41A family
KNN14_03555	COG0305	Participates in initiation and elongation during chromosome replication
KNN14_03560	COG0251	oxidation-reduction process
KNN14_03565	COG0705	Rhomboid family
KNN14_03570	COG1137	ATPase activity
KNN14_03580	COG1187	pseudouridine synthase activity
KNN14_03590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KNN14_03595	COG0750	zinc metalloprotease
KNN14_03600	COG0432	Pfam Uncharacterised protein family UPF0047
KNN14_03610	COG2151	metal-sulfur cluster biosynthetic enzyme
KNN14_03630	COG0544	peptidyl-prolyl cis-trans isomerase activity
KNN14_03635	COG0740	serine-type endopeptidase activity
KNN14_03640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KNN14_03650	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KNN14_03655	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KNN14_03660	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KNN14_03665	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KNN14_03680	COG0509	glycine decarboxylation via glycine cleavage system
KNN14_03685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KNN14_03690	COG0742	ribosomal rna small subunit methyltransferase
KNN14_03695	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KNN14_03705	COG0519	Catalyzes the synthesis of GMP from XMP
KNN14_03710	COG0004	ammonium transporteR
KNN14_03715	COG0174	glutamine synthetase
KNN14_03720	COG0347	Belongs to the P(II) protein family
KNN14_03740	COG1324	tolerance protein
KNN14_03745	COG0445	tRNA wobble uridine modification
KNN14_03755	COG0584	glycerophosphoryl diester phosphodiesterase
KNN14_03760	COG0217	transcriptional regulatory protein
KNN14_03765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KNN14_03775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KNN14_03785	COG0248	Ppx GppA phosphatase
KNN14_03805	COG2204	response regulator
KNN14_03810	COG5002	protein histidine kinase activity
KNN14_03820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNN14_03825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KNN14_03835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KNN14_03850	COG1611	Belongs to the LOG family
KNN14_03860	COG0419	ATPase involved in DNA repair
KNN14_03865	COG0612	Peptidase, M16
KNN14_03870	COG0612	Peptidase, M16
KNN14_03880	COG1191	sigma factor activity
KNN14_03885	COG0095	Lipoate-protein ligase
KNN14_03905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KNN14_03915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KNN14_03925	COG0546	phosphoglycolate phosphatase activity
KNN14_03945	COG2204	response regulator
KNN14_03955	COG0196	riboflavin kinase activity
KNN14_03975	COG3956	TIGRFAM MazG family protein
KNN14_03980	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KNN14_03985	COG1104	cysteine desulfurase activity
KNN14_03990	COG0489	protein tyrosine kinase activity
KNN14_04000	COG0019	diaminopimelate decarboxylase activity
KNN14_04015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KNN14_04030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KNN14_04035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KNN14_04040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KNN14_04045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN14_04050	COG3302	dmso reductase anchor subunit
KNN14_04065	COG0237	dephospho-CoA kinase activity
KNN14_04070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KNN14_04075	COG1490	D-aminoacyl-tRNA deacylase activity
KNN14_04085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KNN14_04090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KNN14_04100	COG0751	glycine-tRNA ligase activity
KNN14_04105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KNN14_04105	COG0574	Belongs to the PEP-utilizing enzyme family
KNN14_04110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KNN14_04125	COG0521	Mo-molybdopterin cofactor biosynthetic process
KNN14_04130	COG0482	sulfurtransferase activity
KNN14_04135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KNN14_04170	COG0848	biopolymer transport protein
KNN14_04175	COG0811	peptide transport
KNN14_04220	COG0598	Magnesium transport protein CorA
KNN14_04225	COG0157	Belongs to the NadC ModD family
KNN14_04230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KNN14_04235	COG0602	queuosine metabolic process
KNN14_04240	COG0860	N-Acetylmuramoyl-L-alanine amidase
KNN14_04255	COG0113	porphobilinogen synthase activity
KNN14_04265	COG0181	hydroxymethylbilane synthase activity
KNN14_04270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KNN14_04275	COG0154	amidase activity
KNN14_04290	COG1704	LemA family
KNN14_04295	COG0484	heat shock protein binding
KNN14_04300	COG0789	Transcriptional regulator
KNN14_04310	COG0490	domain, Protein
KNN14_04315	COG0475	glutathione-regulated potassium exporter activity
KNN14_04330	COG2264	protein methyltransferase activity
KNN14_04335	COG1122	ATPase activity
KNN14_04380	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KNN14_04395	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KNN14_04400	COG0375	protein maturation
KNN14_04425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KNN14_04430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KNN14_04445	COG0793	Belongs to the peptidase S41A family
KNN14_04450	COG0590	tRNA wobble adenosine to inosine editing
KNN14_04460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KNN14_04470	COG3063	Type IV pilus biogenesis stability protein PilW
KNN14_04475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KNN14_04480	COG1618	nucleotide phosphatase activity, acting on free nucleotides
KNN14_04490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KNN14_04510	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KNN14_04515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KNN14_04520	COG0795	lipopolysaccharide-transporting ATPase activity
KNN14_04525	COG0149	triose-phosphate isomerase activity
KNN14_04540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KNN14_04545	COG1968	undecaprenyl-diphosphatase activity
KNN14_04550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KNN14_04555	COG0693	protein deglycase activity
KNN14_04560	COG0601	transmembrane transport
KNN14_04570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KNN14_04575	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KNN14_04585	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KNN14_04590	COG0416	fatty acid biosynthetic process
KNN14_04595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KNN14_04600	COG0644	oxidoreductase
KNN14_04605	COG1388	LysM domain
KNN14_04605	COG0791	NLP P60 protein
KNN14_04610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KNN14_04630	COG0070	glutamate synthase
KNN14_04630	COG0069	glutamate synthase activity
KNN14_04630	COG0067	glutamate synthase
KNN14_04635	COG2270	Major facilitator Superfamily
KNN14_04655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KNN14_04660	COG0633	Ferredoxin
KNN14_04685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN14_04705	COG0564	pseudouridine synthase activity
KNN14_04710	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KNN14_04725	COG0604	alcohol dehydrogenase
KNN14_04730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KNN14_04760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KNN14_04765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KNN14_04780	COG0540	Belongs to the ATCase OTCase family
KNN14_04785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KNN14_04790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KNN14_04810	COG0655	NAD(P)H dehydrogenase (quinone) activity
KNN14_04825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KNN14_04825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KNN14_04845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KNN14_04850	COG1862	Preprotein translocase
KNN14_04855	COG0318	PFAM AMP-dependent synthetase and ligase
KNN14_04860	COG0481	GTPase activity
KNN14_04865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KNN14_04880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KNN14_04885	COG0436	Aminotransferase
KNN14_04890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KNN14_04895	COG0776	regulation of translation
KNN14_04905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KNN14_04910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KNN14_04925	COG1181	Belongs to the D-alanine--D-alanine ligase family
KNN14_04930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KNN14_04945	COG0811	peptide transport
KNN14_04950	COG0848	biopolymer transport protein
KNN14_04960	COG3540	Alkaline phosphatase
KNN14_04965	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KNN14_04970	COG0194	GDP metabolic process
KNN14_04980	COG0825	malonyl-CoA metabolic process
KNN14_04995	COG1758	RNA polymerase activity
KNN14_05005	COG0739	heme binding
KNN14_05005	COG1196	nuclear chromosome segregation
KNN14_05005	COG0741	lytic transglycosylase activity
KNN14_05010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KNN14_05020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KNN14_05025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNN14_05030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KNN14_05080	COG0438	transferase activity, transferring glycosyl groups
KNN14_05100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KNN14_05110	COG0438	transferase activity, transferring glycosyl groups
KNN14_05135	COG1215	transferase activity, transferring glycosyl groups
KNN14_05150	COG2244	polysaccharide biosynthetic process
KNN14_05170	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KNN14_05175	COG1309	transcriptional regulator
KNN14_05180	COG0210	DNA helicase
KNN14_05195	COG0791	NLP P60 protein
KNN14_05200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KNN14_05205	COG0752	glycyl-tRNA synthetase alpha subunit
KNN14_05210	COG1515	deoxyribonuclease V activity
KNN14_05220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KNN14_05235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KNN14_05240	COG1837	Belongs to the UPF0109 family
KNN14_05245	COG0228	four-way junction DNA binding
KNN14_05250	COG2217	Heavy metal translocating P-type atpase
KNN14_05255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KNN14_05265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KNN14_05270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KNN14_05275	COG0193	aminoacyl-tRNA hydrolase activity
KNN14_05285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KNN14_05285	COG0517	IMP dehydrogenase activity
KNN14_05290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KNN14_05295	COG0747	negative chemotaxis
KNN14_05300	COG0745	RESPONSE REGULATOR receiver
KNN14_05310	COG0312	modulator of DNA gyrase
KNN14_05315	COG0575	Belongs to the CDS family
KNN14_05320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KNN14_05330	COG1980	fructose-bisphosphate aldolase activity
KNN14_05345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KNN14_05360	COG1331	Highly conserved protein containing a thioredoxin domain
KNN14_05365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KNN14_05380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KNN14_05395	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KNN14_05400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KNN14_05405	COG1796	DNA polymerase
KNN14_05405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KNN14_05410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KNN14_05420	COG1692	metallophosphoesterase
KNN14_05430	COG0446	pyridine nucleotide-disulphide oxidoreductase
KNN14_05445	COG0642	Histidine kinase
KNN14_05450	COG2204	response regulator
KNN14_05465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN14_05480	COG1349	DNA-binding transcription factor activity
KNN14_05495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KNN14_05505	COG1110	DNA topoisomerase II activity
KNN14_05510	COG1160	GTP binding
KNN14_05520	COG1832	CoA-binding protein
KNN14_05525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KNN14_05530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KNN14_05535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KNN14_05540	COG0542	response to heat
KNN14_05545	COG1254	Belongs to the acylphosphatase family
KNN14_05550	COG1705	Flagellar rod assembly protein muramidase FlgJ
KNN14_05550	COG1388	LysM domain
KNN14_05555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KNN14_05565	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
KNN14_05575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KNN14_05580	COG1858	cytochrome C peroxidase
KNN14_05585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN14_05595	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KNN14_05605	COG0438	transferase activity, transferring glycosyl groups
KNN14_05615	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KNN14_05625	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KNN14_05630	COG0504	CTP synthase activity
KNN14_05635	COG1408	metallophosphoesterase
KNN14_05640	COG0745	RESPONSE REGULATOR receiver
KNN14_05645	COG5016	pyruvate
KNN14_05645	COG0511	ligase activity, forming carbon-carbon bonds
KNN14_05650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KNN14_05655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KNN14_05670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KNN14_05675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KNN14_05675	COG0519	Catalyzes the synthesis of GMP from XMP
KNN14_05695	COG5000	phosphorelay sensor kinase activity
KNN14_05700	COG0704	Plays a role in the regulation of phosphate uptake
KNN14_05705	COG3842	ATPase activity
KNN14_05740	COG1276	copper resistance
KNN14_05745	COG0459	protein refolding
KNN14_05750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KNN14_05760	COG1030	water channel activity
KNN14_05765	COG0140	phosphoribosyl-ATP diphosphatase activity
KNN14_05765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KNN14_05775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KNN14_05780	COG0215	cysteine-tRNA ligase activity
KNN14_05785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KNN14_05790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KNN14_05805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KNN14_05805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KNN14_05810	COG1923	regulation of RNA biosynthetic process
KNN14_05815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KNN14_05820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KNN14_05840	COG3746	phosphate-selective porin O and P
KNN14_05855	COG0859	PFAM glycosyl transferase family 9
KNN14_05865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KNN14_05870	COG0019	diaminopimelate decarboxylase activity
KNN14_05875	COG0632	four-way junction helicase activity
KNN14_05885	COG1333	cytochrome c biogenesis protein
KNN14_05910	COG0357	Ribosomal RNA small subunit methyltransferase G
KNN14_05915	COG1999	signal sequence binding
KNN14_05920	COG0642	Histidine kinase
KNN14_05935	COG1100	Small GTP-binding protein
KNN14_05945	COG0799	negative regulation of ribosome biogenesis
KNN14_05950	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KNN14_05955	COG1530	ribonuclease E activity
KNN14_05965	COG0095	Lipoate-protein ligase
KNN14_05970	COG0138	bifunctional purine biosynthesis protein purh
KNN14_05980	COG2871	sodium ion transport
KNN14_05985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KNN14_05990	COG0123	including yeast histone deacetylase and acetoin utilization protein
KNN14_06030	COG0628	permease
KNN14_06035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KNN14_06050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KNN14_06055	COG0066	3-isopropylmalate dehydratase activity
KNN14_06060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KNN14_06065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KNN14_06080	COG0148	phosphopyruvate hydratase activity
KNN14_06095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KNN14_06095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KNN14_06100	COG0336	Belongs to the RNA methyltransferase TrmD family
KNN14_06125	COG0242	peptide deformylase activity
KNN14_06145	COG0322	excinuclease ABC activity
KNN14_06180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KNN14_06190	COG0508	dehydrogenase complex catalyzes the overall conversion of
KNN14_06200	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KNN14_06205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KNN14_06220	COG0484	heat shock protein binding
KNN14_06230	COG1121	(ABC) transporter
KNN14_06250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KNN14_06260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KNN14_06265	COG0497	DNA recombination
KNN14_06270	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
KNN14_06275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN14_06280	COG0839	Belongs to the complex I subunit 6 family
KNN14_06285	COG0713	ATP synthesis coupled electron transport
KNN14_06295	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN14_06300	COG1007	ATP synthesis coupled electron transport
KNN14_06310	COG0649	NAD binding
KNN14_06310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN14_06315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KNN14_06320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN14_06325	COG0839	Belongs to the complex I subunit 6 family
KNN14_06330	COG0713	ATP synthesis coupled electron transport
KNN14_06345	COG1007	ATP synthesis coupled electron transport
KNN14_06350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNN14_06360	COG0133	tryptophan synthase activity
KNN14_06365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KNN14_06375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KNN14_06405	COG2176	DNA-directed DNA polymerase activity
KNN14_06425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KNN14_06465	COG0006	proline dipeptidase activity
KNN14_06470	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KNN14_06475	COG1253	flavin adenine dinucleotide binding
KNN14_06480	COG4608	Belongs to the ABC transporter superfamily
KNN14_06485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KNN14_06505	COG0437	4 iron, 4 sulfur cluster binding
KNN14_06510	COG2864	formate dehydrogenase
KNN14_06515	COG2032	superoxide dismutase activity
KNN14_06520	COG3058	Necessary for formate dehydrogenase activity
KNN14_06525	COG0509	glycine decarboxylation via glycine cleavage system
KNN14_06540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KNN14_06560	COG1763	Mo-molybdopterin cofactor biosynthetic process
KNN14_06565	COG0083	homoserine kinase activity
KNN14_06570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KNN14_06575	COG0617	tRNA 3'-terminal CCA addition
KNN14_06600	COG2200	EAL domain
KNN14_06610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KNN14_06620	COG0581	inorganic phosphate transmembrane transporter activity
KNN14_06625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KNN14_06630	COG0824	Thioesterase
KNN14_06640	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KNN14_06640	COG0662	Cupin 2, conserved barrel domain protein
KNN14_06650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KNN14_06665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KNN14_06670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KNN14_06670	COG1017	nitric oxide dioxygenase activity
KNN14_06685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNN14_06695	COG1116	anion transmembrane transporter activity
KNN14_06695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNN14_06700	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
KNN14_06705	COG2223	nitrite transmembrane transporter activity
KNN14_06710	COG0243	molybdopterin cofactor binding
KNN14_06720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KNN14_06725	COG1203	CRISPR-associated helicase, Cas3
KNN14_06755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KNN14_06760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KNN14_06765	COG0571	ribonuclease III activity
KNN14_06785	COG1397	ADP-ribosylglycohydrolase
KNN14_06790	COG1923	regulation of RNA biosynthetic process
KNN14_06795	COG3411	Ferredoxin
KNN14_06800	COG2067	long-chain fatty acid transport protein
KNN14_06805	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
KNN14_06810	COG0463	Glycosyl transferase, family 2
KNN14_06815	COG0297	glycogen (starch) synthase activity
KNN14_06820	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KNN14_06820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KNN14_06825	COG1381	Involved in DNA repair and RecF pathway recombination
KNN14_06840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KNN14_06885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KNN14_06890	COG1012	belongs to the aldehyde dehydrogenase family
KNN14_06895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KNN14_06905	COG0275	rRNA processing
KNN14_06910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KNN14_06915	COG0335	large ribosomal subunit rRNA binding
KNN14_06930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KNN14_06945	COG0354	folic acid binding
KNN14_06950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KNN14_06955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KNN14_06960	COG0589	response to stress
KNN14_06965	COG0187	DNA topoisomerase II activity
KNN14_06985	COG1845	cytochrome c oxidase, subunit III
KNN14_07000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN14_07000	COG1845	cytochrome c oxidase, subunit III
KNN14_07025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KNN14_07040	COG0556	nucleotide-excision repair
KNN14_07045	COG1216	Glycosyl transferase, family 2
KNN14_07045	COG1442	glycosyl transferase family 8
KNN14_07050	COG2222	sugar isomerase
KNN14_07060	COG0438	transferase activity, transferring glycosyl groups
KNN14_07070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KNN14_07080	COG1477	protein flavinylation
KNN14_07095	COG0037	tRNA processing
KNN14_07105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KNN14_07120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KNN14_07125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KNN14_07130	COG1305	Transglutaminase-like
KNN14_07135	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KNN14_07145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KNN14_07155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KNN14_07160	COG0473	3-isopropylmalate dehydrogenase activity
KNN14_07175	COG0537	adenosine 5'-monophosphoramidase activity
KNN14_07180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KNN14_07185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KNN14_07195	COG3547	Transposase (IS116 IS110 IS902 family)
KNN14_07200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNN14_07205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KNN14_07215	COG0438	transferase activity, transferring glycosyl groups
KNN14_07265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KNN14_07270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KNN14_07275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KNN14_07280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KNN14_07285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KNN14_07290	COG1278	Cold shock
KNN14_07295	COG0285	dihydrofolate synthase activity
KNN14_07300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KNN14_07305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KNN14_07310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KNN14_07325	COG2226	methyltransferase
KNN14_07325	COG1073	alpha beta
KNN14_07330	COG2226	methyltransferase
KNN14_07335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN14_07340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KNN14_07345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KNN14_07350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KNN14_07360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KNN14_07380	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KNN14_07390	COG2346	COG2346, Truncated hemoglobins
KNN14_07405	COG0410	ABC transporter
KNN14_07410	COG1137	ATPase activity
KNN14_07435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KNN14_07455	COG1127	ABC transporter
KNN14_07460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KNN14_07475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KNN14_07485	COG2046	Belongs to the sulfate adenylyltransferase family
KNN14_07490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KNN14_07505	COG0175	sulfate reduction
KNN14_07515	COG0363	glucosamine-6-phosphate deaminase activity
KNN14_07520	COG2204	response regulator
KNN14_07525	COG0517	IMP dehydrogenase activity
KNN14_07525	COG0516	GMP reductase activity
KNN14_07540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KNN14_07545	COG0475	glutathione-regulated potassium exporter activity
KNN14_07550	COG0756	dUTP diphosphatase activity
KNN14_07560	COG1185	polyribonucleotide nucleotidyltransferase activity
KNN14_07565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KNN14_07575	COG0557	exoribonuclease II activity
KNN14_07580	COG1706	bacterial-type flagellum-dependent cell motility
KNN14_07585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KNN14_07590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KNN14_07595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KNN14_07600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KNN14_07605	COG0730	response to heat
KNN14_07610	COG0778	Nitroreductase
KNN14_07615	COG2249	NAD(P)H dehydrogenase (quinone) activity
KNN14_07620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KNN14_07630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KNN14_07640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KNN14_07655	COG0534	Mate efflux family protein
KNN14_07665	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KNN14_07670	COG2322	membrane
KNN14_07690	COG3256	nitric oxide reductase
KNN14_07695	COG2010	Cytochrome c
KNN14_07700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KNN14_07705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KNN14_07710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNN14_07725	COG0698	ribose 5-phosphate isomerase
KNN14_07735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KNN14_07740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KNN14_07750	COG0105	UTP biosynthetic process
KNN14_07755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KNN14_07760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KNN14_07765	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KNN14_07770	COG0439	Biotin carboxylase
KNN14_07795	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KNN14_07800	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KNN14_07805	COG1766	The M ring may be actively involved in energy transduction
KNN14_07810	COG1677	Flagellar hook-basal body complex protein FliE
KNN14_07815	COG1558	bacterial-type flagellum-dependent cell motility
KNN14_07820	COG1815	bacterial-type flagellum-dependent cell motility
KNN14_07830	COG0343	queuine tRNA-ribosyltransferase activity
KNN14_07835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KNN14_07840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KNN14_07855	COG0811	peptide transport
KNN14_07865	COG0406	alpha-ribazole phosphatase activity
KNN14_07870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KNN14_07880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KNN14_07885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KNN14_07900	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KNN14_07905	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KNN14_07945	COG1203	CRISPR-associated helicase, Cas3
KNN14_07955	COG1518	maintenance of DNA repeat elements
KNN14_07960	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KNN14_07970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KNN14_07975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KNN14_07985	COG0463	Glycosyl transferase, family 2
KNN14_07990	COG0583	DNA-binding transcription factor activity
KNN14_07995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KNN14_08000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KNN14_08005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KNN14_08030	COG1509	lysine 2,3-aminomutase activity
KNN14_08035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KNN14_08040	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KNN14_08045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KNN14_08050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KNN14_08065	COG5016	pyruvate
KNN14_08065	COG0511	ligase activity, forming carbon-carbon bonds
KNN14_08070	COG0439	Biotin carboxylase
KNN14_08080	COG0314	molybdopterin synthase activity
KNN14_08085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KNN14_08090	COG2835	tetraacyldisaccharide 4'-kinase activity
KNN14_08100	COG0583	DNA-binding transcription factor activity
KNN14_08105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KNN14_08110	COG2084	Dehydrogenase
KNN14_08120	COG3830	Belongs to the UPF0237 family
KNN14_08125	COG0242	peptide deformylase activity
KNN14_08145	COG0151	Belongs to the GarS family
KNN14_08150	COG0512	Glutamine amidotransferase of anthranilate synthase
KNN14_08150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KNN14_08160	COG1663	tetraacyldisaccharide 4'-kinase activity
KNN14_08180	COG0438	transferase activity, transferring glycosyl groups
KNN14_08210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KNN14_08220	COG0135	phosphoribosylanthranilate isomerase activity
KNN14_08225	COG2050	protein possibly involved in aromatic compounds catabolism
KNN14_08225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KNN14_08230	COG0501	Belongs to the peptidase M48B family
KNN14_08240	COG1519	Transferase
KNN14_08245	COG1260	myo-inositol-1-phosphate synthase
KNN14_08255	COG0509	glycine decarboxylation via glycine cleavage system
KNN14_08260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KNN14_08270	COG2814	Major facilitator Superfamily
KNN14_08300	COG1702	phosphate starvation-inducible protein PhoH
KNN14_08305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KNN14_08310	COG0101	tRNA pseudouridine synthase activity
KNN14_08320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KNN14_08325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KNN14_08345	COG1067	ATP-dependent peptidase activity
KNN14_08355	COG4786	Flagellar basal body rod
KNN14_08360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KNN14_08365	COG0352	thiamine-phosphate diphosphorylase activity
KNN14_08370	COG0735	belongs to the Fur family
KNN14_08385	COG0710	3-dehydroquinate dehydratase activity
KNN14_08390	COG0137	argininosuccinate synthase activity
KNN14_08400	COG1924	4 iron, 4 sulfur cluster binding
KNN14_08410	COG0436	Aminotransferase
KNN14_08415	COG0733	neurotransmitter:sodium symporter activity
KNN14_08425	COG0123	including yeast histone deacetylase and acetoin utilization protein
KNN14_08435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN14_08440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KNN14_08450	COG2022	thiamine diphosphate biosynthetic process
KNN14_08465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KNN14_08470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KNN14_08475	COG0037	tRNA processing
KNN14_08485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KNN14_08490	COG1959	2 iron, 2 sulfur cluster binding
KNN14_08495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KNN14_08495	COG1328	CTP reductase activity
KNN14_08500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KNN14_08500	COG1648	precorrin-2 dehydrogenase activity
KNN14_08505	COG0330	HflC and HflK could
KNN14_08515	COG0077	Prephenate dehydratase
KNN14_08515	COG1605	Chorismate mutase
KNN14_08525	COG2022	thiamine diphosphate biosynthetic process
KNN14_08525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNN14_08545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KNN14_08545	COG0517	IMP dehydrogenase activity
KNN14_08545	COG0617	tRNA 3'-terminal CCA addition
KNN14_08570	COG1994	Peptidase M50
KNN14_08575	COG1053	succinate dehydrogenase
KNN14_08585	COG4274	PFAM GYD family protein
KNN14_08595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KNN14_08620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KNN14_08625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KNN14_08650	COG0720	synthase
KNN14_08665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KNN14_08665	COG0758	DNA mediated transformation
KNN14_08670	COG0315	cyclic pyranopterin monophosphate synthase activity
KNN14_08700	COG0658	competence protein
KNN14_08705	COG2226	methyltransferase
KNN14_08710	COG3706	GGDEF domain
KNN14_08715	COG1496	oxidoreductase activity
KNN14_08720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KNN14_08725	COG0455	bacterial-type flagellum organization
KNN14_08730	COG1419	protein localization to endoplasmic reticulum
KNN14_08735	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KNN14_08740	COG0442	prolyl-tRNA aminoacylation
KNN14_08745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KNN14_08750	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
KNN14_08760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KNN14_08765	COG1592	Rubrerythrin
KNN14_08770	COG0247	lactate metabolic process
KNN14_08790	COG1921	L-seryl-tRNASec selenium transferase activity
KNN14_08795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KNN14_08800	COG0072	phenylalanine-tRNA ligase activity
KNN14_08800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN14_08815	COG1418	mRNA catabolic process
KNN14_08815	COG3599	regulation of cell shape
KNN14_08825	COG1793	dna ligase
KNN14_08835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KNN14_08840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KNN14_08845	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KNN14_08850	COG0058	SHG alpha-glucan phosphorylase activity
KNN14_08855	COG0477	Major facilitator Superfamily
KNN14_08865	COG1573	uracil-dna glycosylase
KNN14_08870	COG0003	Pfam Anion-transporting ATPase
KNN14_08875	COG0745	RESPONSE REGULATOR receiver
KNN14_08885	COG0484	heat shock protein binding
KNN14_08890	COG0835	chemotaxis
KNN14_08895	COG0643	Histidine kinase
KNN14_08895	COG0784	Response regulator, receiver
KNN14_08895	COG2198	Histidine kinase
KNN14_08900	COG0784	Response regulator, receiver
KNN14_08900	COG0835	chemotaxis
KNN14_08905	COG0840	transmembrane signaling receptor activity
KNN14_08915	COG0840	transmembrane signaling receptor activity
KNN14_08920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KNN14_08925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KNN14_08930	COG1334	flagellar protein FlaG
KNN14_08935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KNN14_08940	COG1516	flagellar protein fliS
KNN14_08950	COG0142	geranyltranstransferase activity
KNN14_08955	COG0492	ferredoxin-NADP+ reductase activity
KNN14_08970	COG1193	negative regulation of DNA recombination
KNN14_08975	COG0446	pyridine nucleotide-disulphide oxidoreductase
KNN14_08985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KNN14_08995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KNN14_09010	COG0746	molybdenum cofactor guanylyltransferase activity
KNN14_09020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KNN14_09025	COG0681	Belongs to the peptidase S26 family
KNN14_09045	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KNN14_09050	COG0762	integral membrane protein
KNN14_09055	COG0203	ribosomal protein L17
KNN14_09060	COG0202	RNA polymerase activity
KNN14_09065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KNN14_09070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KNN14_09075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KNN14_09080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KNN14_09085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KNN14_09090	COG0024	Methionine aminopeptidase
KNN14_09095	COG0563	adenylate kinase activity
KNN14_09100	COG0201	protein transport
KNN14_09105	COG0200	Binds to the 23S rRNA
KNN14_09110	COG1841	ribosomal large subunit assembly
KNN14_09115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KNN14_09125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KNN14_09130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KNN14_09135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KNN14_09140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KNN14_09150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KNN14_09160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KNN14_09165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KNN14_09170	COG2814	Major facilitator Superfamily
KNN14_09175	COG2199	diguanylate cyclase activity
KNN14_09175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KNN14_09180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KNN14_09200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN14_09200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN14_09205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KNN14_09215	COG0587	DNA-directed DNA polymerase activity
KNN14_09220	COG1547	Domain of unknown function (DUF309)
KNN14_09245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KNN14_09250	COG0358	DNA primase activity
KNN14_09260	COG3300	MHYT domain
KNN14_09260	COG5001	Diguanylate cyclase
KNN14_09265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KNN14_09270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KNN14_09285	COG1881	PFAM PEBP family protein
KNN14_09295	COG0525	valine-tRNA ligase activity
KNN14_09300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KNN14_09335	COG0745	RESPONSE REGULATOR receiver
KNN14_09345	COG0095	Lipoate-protein ligase
KNN14_09360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KNN14_09365	COG0180	Tryptophanyl-tRNA synthetase
KNN14_09395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KNN14_09430	COG0277	FAD linked oxidase domain protein
KNN14_09440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KNN14_09445	COG1640	4-alpha-glucanotransferase