locus-tag	class	description
KSP35_00010	COG1136	(ABC) transporter
KSP35_00035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KSP35_00040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KSP35_00045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KSP35_00050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KSP35_00055	COG0822	iron-sulfur transferase activity
KSP35_00060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KSP35_00065	COG0396	ATPase activity
KSP35_00075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KSP35_00080	COG1876	peptidase activity
KSP35_00100	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_00120	COG1960	acyl-CoA dehydrogenase activity
KSP35_00175	COG1136	(ABC) transporter
KSP35_00180	COG0328	RNA-DNA hybrid ribonuclease activity
KSP35_00245	COG1970	mechanosensitive ion channel activity
KSP35_00260	COG1086	Polysaccharide biosynthesis protein
KSP35_00265	COG0277	FAD linked oxidase domain protein
KSP35_00270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KSP35_00300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KSP35_00305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KSP35_00310	COG0508	dehydrogenase complex catalyzes the overall conversion of
KSP35_00315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KSP35_00335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KSP35_00375	COG2197	response regulator
KSP35_00385	COG1793	dna ligase
KSP35_00385	COG3285	dna ligase
KSP35_00405	COG0646	methionine synthase
KSP35_00405	COG1410	methionine synthase
KSP35_00415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KSP35_00465	COG2894	cell division
KSP35_00525	COG1674	ftsk spoiiie
KSP35_00535	COG0515	serine threonine protein kinase
KSP35_00540	COG0714	Associated with various cellular activities
KSP35_00570	COG0714	Associated with various cellular activities
KSP35_00650	COG2070	2-Nitropropane dioxygenase
KSP35_00660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KSP35_00690	COG1960	acyl-CoA dehydrogenase activity
KSP35_00700	COG1960	acyl-CoA dehydrogenase activity
KSP35_00705	COG3447	MASE1 domain protein
KSP35_00705	COG5001	Diguanylate cyclase
KSP35_00705	COG5002	protein histidine kinase activity
KSP35_00710	COG1703	isobutyryl-CoA mutase activity
KSP35_00720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KSP35_00720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KSP35_00755	COG1674	ftsk spoiiie
KSP35_00755	COG0433	COG0433 Predicted ATPase
KSP35_00780	COG4770	biotin carboxylase activity
KSP35_00785	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KSP35_00785	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KSP35_00790	COG1365	unkown
KSP35_00795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KSP35_00800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KSP35_00805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KSP35_00805	COG0512	Glutamine amidotransferase of anthranilate synthase
KSP35_00810	COG1960	acyl-CoA dehydrogenase activity
KSP35_00815	COG1316	TRANSCRIPTIONal
KSP35_00820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KSP35_00835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KSP35_00860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KSP35_00875	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
KSP35_00875	COG0778	Nitroreductase
KSP35_00880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KSP35_00895	COG1395	domain, Protein
KSP35_00905	COG0514	ATP-dependent DNA helicase (RecQ)
KSP35_00910	COG1011	Hydrolase
KSP35_00940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KSP35_00955	COG1525	nuclease
KSP35_00960	COG0183	Belongs to the thiolase family
KSP35_01000	COG1024	Enoyl-CoA hydratase
KSP35_01020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KSP35_01025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KSP35_01045	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KSP35_01050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KSP35_01060	COG0469	pyruvate kinase activity
KSP35_01075	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_01100	COG0671	phosphoesterase, PA-phosphatase related
KSP35_01110	COG1091	dTDP-4-dehydrorhamnose reductase activity
KSP35_01150	COG0405	Gamma-glutamyltransferase
KSP35_01155	COG0405	Gamma-glutamyltransferase
KSP35_01165	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_01190	COG1960	acyl-CoA dehydrogenase activity
KSP35_01210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_01225	COG2070	2-Nitropropane dioxygenase
KSP35_01235	COG0644	oxidoreductase
KSP35_01250	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_01255	COG2030	dehydratase
KSP35_01265	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
KSP35_01275	COG2770	Histidine kinase
KSP35_01275	COG2208	phosphoserine phosphatase activity
KSP35_01305	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KSP35_01325	COG0495	leucyl-tRNA aminoacylation
KSP35_01330	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_01340	COG1191	sigma factor activity
KSP35_01355	COG1366	Belongs to the anti-sigma-factor antagonist family
KSP35_01360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KSP35_01390	COG0723	plastoquinol--plastocyanin reductase activity
KSP35_01395	COG2010	Cytochrome c
KSP35_01410	COG0210	DNA helicase
KSP35_01450	COG1555	photosystem II stabilization
KSP35_01475	COG0268	Binds directly to 16S ribosomal RNA
KSP35_01480	COG0481	GTPase activity
KSP35_01495	COG1420	regulation of RNA biosynthetic process
KSP35_01500	COG0484	heat shock protein binding
KSP35_01520	COG1011	Hydrolase
KSP35_01535	COG0488	(ABC) transporter
KSP35_01560	COG0438	transferase activity, transferring glycosyl groups
KSP35_01565	COG0275	rRNA processing
KSP35_01595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KSP35_01620	COG2326	polyphosphate kinase activity
KSP35_01625	COG2205	protein histidine kinase activity
KSP35_01635	COG1960	acyl-CoA dehydrogenase activity
KSP35_01645	COG3250	beta-galactosidase activity
KSP35_01680	COG0386	Belongs to the glutathione peroxidase family
KSP35_01685	COG0513	Belongs to the DEAD box helicase family
KSP35_01700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KSP35_01715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KSP35_01765	COG2205	protein histidine kinase activity
KSP35_01775	COG0672	)-iron permease
KSP35_01785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KSP35_01805	COG0671	phosphoesterase, PA-phosphatase related
KSP35_01820	COG0745	RESPONSE REGULATOR receiver
KSP35_01880	COG1595	DNA-templated transcription, initiation
KSP35_01900	COG1053	succinate dehydrogenase
KSP35_01965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KSP35_01980	COG1063	alcohol dehydrogenase
KSP35_01985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KSP35_01995	COG1024	Enoyl-CoA hydratase
KSP35_02000	COG0596	Alpha beta hydrolase
KSP35_02000	COG2945	thiolester hydrolase activity
KSP35_02010	COG0747	negative chemotaxis
KSP35_02020	COG2018	Roadblock/LC7 domain
KSP35_02040	COG2072	flavoprotein involved in K transport
KSP35_02045	COG1309	transcriptional regulator
KSP35_02070	COG2378	regulation of single-species biofilm formation
KSP35_02075	COG1278	Cold shock
KSP35_02080	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_02140	COG1331	Highly conserved protein containing a thioredoxin domain
KSP35_02145	COG1652	LysM domain
KSP35_02160	COG4208	sulfate ABC transporter
KSP35_02165	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KSP35_02170	COG0517	IMP dehydrogenase activity
KSP35_02185	COG2267	carboxylic ester hydrolase activity
KSP35_02190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KSP35_02200	COG2226	methyltransferase
KSP35_02205	COG3022	response to hydroperoxide
KSP35_02215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KSP35_02230	COG0489	protein tyrosine kinase activity
KSP35_02260	COG2197	response regulator
KSP35_02270	COG0237	dephospho-CoA kinase activity
KSP35_02280	COG0556	nucleotide-excision repair
KSP35_02315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KSP35_02320	COG1215	transferase activity, transferring glycosyl groups
KSP35_02330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KSP35_02355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KSP35_02380	COG2226	methyltransferase
KSP35_02390	COG1660	Displays ATPase and GTPase activities
KSP35_02395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KSP35_02400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KSP35_02405	COG0126	phosphoglycerate kinase activity
KSP35_02410	COG0149	triose-phosphate isomerase activity
KSP35_02420	COG0601	transmembrane transport
KSP35_02425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KSP35_02430	COG4608	Belongs to the ABC transporter superfamily
KSP35_02435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KSP35_02450	COG0270	DNA (cytosine-5-)-methyltransferase activity
KSP35_02485	COG4555	ABC transporter
KSP35_02520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KSP35_02545	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KSP35_02545	COG1672	PFAM Archaeal ATPase
KSP35_02565	COG1063	alcohol dehydrogenase
KSP35_02575	COG1309	transcriptional regulator
KSP35_02580	COG1181	Belongs to the D-alanine--D-alanine ligase family
KSP35_02605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KSP35_02630	COG2205	protein histidine kinase activity
KSP35_02635	COG0531	amino acid
KSP35_02660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_02675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KSP35_02680	COG3469	chitinase activity
KSP35_02700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KSP35_02730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KSP35_02745	COG0745	RESPONSE REGULATOR receiver
KSP35_02755	COG2205	protein histidine kinase activity
KSP35_02765	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KSP35_02800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KSP35_02830	COG2301	Belongs to the HpcH HpaI aldolase family
KSP35_02855	COG1960	acyl-CoA dehydrogenase activity
KSP35_02860	COG0745	RESPONSE REGULATOR receiver
KSP35_02875	COG5001	Diguanylate cyclase
KSP35_02875	COG4251	negative regulation of phosphorylation
KSP35_02875	COG3706	GGDEF domain
KSP35_02875	COG2203	Gaf domain
KSP35_02890	COG1960	acyl-CoA dehydrogenase activity
KSP35_02905	COG0686	Belongs to the AlaDH PNT family
KSP35_02910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KSP35_02915	COG1177	transmembrane transport
KSP35_02920	COG1176	ABC-type spermidine putrescine transport system, permease component I
KSP35_02930	COG3842	ATPase activity
KSP35_02935	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_02945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSP35_02965	COG1564	THIamine pyrophosphokinase
KSP35_02985	COG1119	ATPase activity
KSP35_02995	COG0215	cysteine-tRNA ligase activity
KSP35_03020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KSP35_03025	COG0438	transferase activity, transferring glycosyl groups
KSP35_03030	COG1704	LemA family
KSP35_03035	COG0501	Belongs to the peptidase M48B family
KSP35_03040	COG1470	cell adhesion involved in biofilm formation
KSP35_03050	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KSP35_03060	COG0217	transcriptional regulatory protein
KSP35_03065	COG0667	Aldo Keto reductase
KSP35_03070	COG0450	alkyl hydroperoxide reductase
KSP35_03080	COG4941	Belongs to the sigma-70 factor family
KSP35_03085	COG3795	YCII-related domain
KSP35_03100	COG4555	ABC transporter
KSP35_03105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KSP35_03110	COG0632	four-way junction helicase activity
KSP35_03115	COG2255	four-way junction helicase activity
KSP35_03125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KSP35_03130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KSP35_03130	COG1473	amidohydrolase
KSP35_03140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KSP35_03145	COG0343	queuine tRNA-ribosyltransferase activity
KSP35_03155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KSP35_03160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KSP35_03165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KSP35_03180	COG2267	carboxylic ester hydrolase activity
KSP35_03185	COG0402	S-adenosylhomocysteine deaminase activity
KSP35_03195	COG3634	alkyl hydroperoxide reductase activity
KSP35_03200	COG0583	DNA-binding transcription factor activity
KSP35_03205	COG0124	histidyl-tRNA synthetase
KSP35_03210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KSP35_03245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KSP35_03265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KSP35_03275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KSP35_03280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KSP35_03285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KSP35_03290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KSP35_03300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KSP35_03305	COG0006	proline dipeptidase activity
KSP35_03310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KSP35_03315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KSP35_03325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KSP35_03330	COG0540	Belongs to the ATCase OTCase family
KSP35_03335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KSP35_03340	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_03345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KSP35_03350	COG0505	Belongs to the CarA family
KSP35_03355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KSP35_03360	COG0167	dihydroorotate dehydrogenase activity
KSP35_03365	COG0284	orotidine-5'-phosphate decarboxylase activity
KSP35_03375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KSP35_03390	COG1758	RNA polymerase activity
KSP35_03400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KSP35_03405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KSP35_03410	COG2813	Specifically methylates the guanine in position
KSP35_03415	COG0242	peptide deformylase activity
KSP35_03420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KSP35_03425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KSP35_03425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KSP35_03430	COG0521	Mo-molybdopterin cofactor biosynthetic process
KSP35_03430	COG0315	cyclic pyranopterin monophosphate synthase activity
KSP35_03445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KSP35_03445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KSP35_03450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KSP35_03475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KSP35_03480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KSP35_03485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KSP35_03490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KSP35_03495	COG5002	protein histidine kinase activity
KSP35_03505	COG3228	Belongs to the MtfA family
KSP35_03510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KSP35_03515	COG0072	phenylalanine-tRNA ligase activity
KSP35_03515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KSP35_03570	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_03595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KSP35_03600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KSP35_03615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KSP35_03620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KSP35_03625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KSP35_03630	COG1438	arginine binding
KSP35_03640	COG0165	Argininosuccinate lyase
KSP35_03650	COG1482	cell wall glycoprotein biosynthetic process
KSP35_03670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KSP35_03710	COG1013	pyruvate-flavodoxin oxidoreductase activity
KSP35_03715	COG0584	glycerophosphoryl diester phosphodiesterase
KSP35_03730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KSP35_03750	COG0604	alcohol dehydrogenase
KSP35_03780	COG1127	ABC transporter
KSP35_03785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KSP35_03790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KSP35_03855	COG1024	Enoyl-CoA hydratase
KSP35_03940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KSP35_03940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KSP35_03970	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KSP35_03995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KSP35_04000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KSP35_04010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KSP35_04025	COG2135	peptidase activity
KSP35_04060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KSP35_04065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KSP35_04075	COG2770	Histidine kinase
KSP35_04075	COG2208	phosphoserine phosphatase activity
KSP35_04080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KSP35_04090	COG1160	GTP binding
KSP35_04100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KSP35_04140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KSP35_04145	COG0287	Prephenate dehydrogenase
KSP35_04155	COG1187	pseudouridine synthase activity
KSP35_04160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KSP35_04165	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KSP35_04170	COG0180	Tryptophanyl-tRNA synthetase
KSP35_04180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KSP35_04190	COG0494	nUDIX hydrolase
KSP35_04195	COG0504	CTP synthase activity
KSP35_04225	COG0497	DNA recombination
KSP35_04230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KSP35_04245	COG0681	Belongs to the peptidase S26 family
KSP35_04250	COG0681	Belongs to the peptidase S26 family
KSP35_04260	COG2378	regulation of single-species biofilm formation
KSP35_04275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KSP35_04285	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KSP35_04290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KSP35_04300	COG4122	O-methyltransferase activity
KSP35_04305	COG1222	aaa ATPase
KSP35_04370	COG1309	transcriptional regulator
KSP35_04375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KSP35_04405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KSP35_04410	COG0363	glucosamine-6-phosphate deaminase activity
KSP35_04415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KSP35_04420	COG1611	Belongs to the LOG family
KSP35_04440	COG0366	Alpha amylase catalytic
KSP35_04445	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KSP35_04450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KSP35_04475	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_04480	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_04485	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_04525	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_04535	COG0277	FAD linked oxidase domain protein
KSP35_04540	COG1024	Enoyl-CoA hydratase
KSP35_04550	COG0747	negative chemotaxis
KSP35_04560	COG0601	transmembrane transport
KSP35_04565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KSP35_04615	COG0492	ferredoxin-NADP+ reductase activity
KSP35_04640	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KSP35_04650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KSP35_04655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KSP35_04670	COG0463	Glycosyl transferase, family 2
KSP35_04680	COG0438	transferase activity, transferring glycosyl groups
KSP35_04685	COG4981	capsule polysaccharide biosynthetic process
KSP35_04750	COG0070	glutamate synthase
KSP35_04750	COG0069	glutamate synthase activity
KSP35_04750	COG0067	glutamate synthase
KSP35_04755	COG1362	aminopeptidase activity
KSP35_04770	COG0739	heme binding
KSP35_04775	COG0427	acetyl-CoA hydrolase
KSP35_04780	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_04805	COG2124	cytochrome p450
KSP35_04810	COG2070	2-Nitropropane dioxygenase
KSP35_04815	COG2124	cytochrome p450
KSP35_04830	COG0513	Belongs to the DEAD box helicase family
KSP35_04850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KSP35_04860	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KSP35_04880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KSP35_04885	COG1595	DNA-templated transcription, initiation
KSP35_04890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KSP35_04895	COG0657	acetylesterase activity
KSP35_04905	COG2188	Transcriptional regulator
KSP35_04910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KSP35_04950	COG0372	Belongs to the citrate synthase family
KSP35_04965	COG0604	alcohol dehydrogenase
KSP35_04970	COG1960	acyl-CoA dehydrogenase activity
KSP35_04975	COG0045	succinate-CoA ligase (ADP-forming) activity
KSP35_04975	COG1042	CoA-binding domain protein
KSP35_04975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KSP35_05005	COG0433	COG0433 Predicted ATPase
KSP35_05015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KSP35_05020	COG1957	nucleoside hydrolase
KSP35_05035	COG2197	response regulator
KSP35_05040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KSP35_05040	COG0519	Catalyzes the synthesis of GMP from XMP
KSP35_05045	COG4585	Histidine kinase
KSP35_05085	COG1937	Protein conserved in bacteria
KSP35_05090	COG0702	epimerase
KSP35_05105	COG5001	Diguanylate cyclase
KSP35_05125	COG3457	Alanine racemase
KSP35_05135	COG3387	PFAM Glycoside hydrolase 15-related
KSP35_05145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KSP35_05155	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_05160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KSP35_05190	COG2226	methyltransferase
KSP35_05190	COG0596	Alpha beta hydrolase
KSP35_05190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KSP35_05195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KSP35_05210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_05220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KSP35_05315	COG4941	Belongs to the sigma-70 factor family
KSP35_05345	COG3046	protein related to deoxyribodipyrimidine photolyase
KSP35_05350	COG0024	Methionine aminopeptidase
KSP35_05455	COG0745	RESPONSE REGULATOR receiver
KSP35_05480	COG1959	2 iron, 2 sulfur cluster binding
KSP35_05485	COG0564	pseudouridine synthase activity
KSP35_05490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KSP35_05495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KSP35_05515	COG1799	cell septum assembly
KSP35_05525	COG1496	oxidoreductase activity
KSP35_05530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KSP35_05535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KSP35_05540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KSP35_05545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KSP35_05550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KSP35_05555	COG0772	Belongs to the SEDS family
KSP35_05560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KSP35_05565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KSP35_05570	COG0768	penicillin binding
KSP35_05580	COG0275	rRNA processing
KSP35_05585	COG2001	Belongs to the MraZ family
KSP35_05600	COG4948	Mandelate Racemase Muconate Lactonizing
KSP35_05620	COG0714	Associated with various cellular activities
KSP35_05645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KSP35_05650	COG1051	belongs to the nudix hydrolase family
KSP35_05650	COG1056	cytidyltransferase-related domain
KSP35_05655	COG1216	Glycosyl transferase, family 2
KSP35_05665	COG0745	RESPONSE REGULATOR receiver
KSP35_05670	COG2205	protein histidine kinase activity
KSP35_05705	COG2318	DinB family
KSP35_05720	COG0436	Aminotransferase
KSP35_05725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KSP35_05730	COG1940	carbohydrate kinase activity
KSP35_05745	COG0003	Pfam Anion-transporting ATPase
KSP35_05760	COG0438	transferase activity, transferring glycosyl groups
KSP35_05790	COG1131	(ABC) transporter
KSP35_05805	COG2197	response regulator
KSP35_05825	COG2733	membrane
KSP35_05840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KSP35_05890	COG1592	Rubrerythrin
KSP35_05895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KSP35_05900	COG0577	efflux transmembrane transporter activity
KSP35_05900	COG1136	(ABC) transporter
KSP35_05905	COG0577	efflux transmembrane transporter activity
KSP35_05905	COG1136	(ABC) transporter
KSP35_05910	COG0277	FAD linked oxidase domain protein
KSP35_05920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KSP35_05945	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KSP35_05955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KSP35_06005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KSP35_06015	COG5001	Diguanylate cyclase
KSP35_06040	COG2175	clavaminate synthase activity
KSP35_06065	COG2197	response regulator
KSP35_06105	COG2197	response regulator
KSP35_06110	COG4585	Histidine kinase
KSP35_06120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KSP35_06140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KSP35_06145	COG0358	DNA primase activity
KSP35_06170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KSP35_06175	COG1381	Involved in DNA repair and RecF pathway recombination
KSP35_06180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KSP35_06185	COG1295	ribonuclease BN
KSP35_06205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KSP35_06215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KSP35_06295	COG0673	inositol 2-dehydrogenase activity
KSP35_06330	COG1674	ftsk spoiiie
KSP35_06340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KSP35_06345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KSP35_06365	COG0589	response to stress
KSP35_06375	COG0586	Pfam SNARE associated Golgi protein
KSP35_06395	COG2192	nodulation
KSP35_06410	COG4941	Belongs to the sigma-70 factor family
KSP35_06430	COG1295	ribonuclease BN
KSP35_06435	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_06470	COG0612	Peptidase, M16
KSP35_06480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KSP35_06490	COG0196	riboflavin kinase activity
KSP35_06495	COG1162	GTPase activity
KSP35_06510	COG1024	Enoyl-CoA hydratase
KSP35_06515	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_06565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KSP35_06590	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_06620	COG0438	transferase activity, transferring glycosyl groups
KSP35_06655	COG0515	serine threonine protein kinase
KSP35_06655	COG2815	serine threonine protein kinase
KSP35_06675	COG2205	protein histidine kinase activity
KSP35_06710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KSP35_06720	COG0243	molybdopterin cofactor binding
KSP35_06735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KSP35_06745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KSP35_06775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KSP35_06780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KSP35_06815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KSP35_06820	COG2359	stage V sporulation protein S
KSP35_06825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KSP35_06830	COG0730	response to heat
KSP35_06835	COG0583	DNA-binding transcription factor activity
KSP35_06850	COG1546	Belongs to the CinA family
KSP35_06850	COG1058	Belongs to the CinA family
KSP35_06865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KSP35_06870	COG1085	galactose-1-phosphate uridylyltransferase
KSP35_06910	COG0708	Exodeoxyribonuclease III
KSP35_06915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KSP35_06950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KSP35_06975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KSP35_07025	COG0159	tryptophan synthase activity
KSP35_07030	COG0133	tryptophan synthase activity
KSP35_07035	COG0135	phosphoribosylanthranilate isomerase activity
KSP35_07045	COG1999	signal sequence binding
KSP35_07055	COG0134	indole-3-glycerol-phosphate synthase activity
KSP35_07060	COG0484	heat shock protein binding
KSP35_07065	COG0354	folic acid binding
KSP35_07075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KSP35_07080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KSP35_07080	COG0140	phosphoribosyl-ATP diphosphatase activity
KSP35_07085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KSP35_07095	COG0107	imidazoleglycerol-phosphate synthase activity
KSP35_07110	COG2130	NADP-dependent
KSP35_07120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KSP35_07125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KSP35_07130	COG0131	Imidazoleglycerol-phosphate dehydratase
KSP35_07135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KSP35_07140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KSP35_07145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KSP35_07160	COG0456	acetyltransferase
KSP35_07165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KSP35_07175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KSP35_07210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KSP35_07225	COG2193	ferroxidase activity
KSP35_07230	COG2226	methyltransferase
KSP35_07240	COG5001	Diguanylate cyclase
KSP35_07250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KSP35_07255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KSP35_07270	COG1435	thymidine kinase activity
KSP35_07290	COG0195	Participates in both transcription termination and antitermination
KSP35_07295	COG0779	Required for maturation of 30S ribosomal subunits
KSP35_07320	COG0442	prolyl-tRNA aminoacylation
KSP35_07340	COG1690	Belongs to the RtcB family
KSP35_07355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KSP35_07365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KSP35_07370	COG0575	Belongs to the CDS family
KSP35_07375	COG0233	cytoplasmic translational termination
KSP35_07380	COG0528	UMP kinase activity
KSP35_07385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KSP35_07390	COG0052	Belongs to the universal ribosomal protein uS2 family
KSP35_07400	COG1191	sigma factor activity
KSP35_07405	COG4974	Belongs to the 'phage' integrase family
KSP35_07410	COG0758	DNA mediated transformation
KSP35_07410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KSP35_07420	COG1024	Enoyl-CoA hydratase
KSP35_07430	COG0792	nuclease activity
KSP35_07440	COG0335	large ribosomal subunit rRNA binding
KSP35_07450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KSP35_07455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KSP35_07460	COG1837	Belongs to the UPF0109 family
KSP35_07465	COG0228	four-way junction DNA binding
KSP35_07485	COG0552	protein localization to endoplasmic reticulum
KSP35_07490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KSP35_07495	COG2205	protein histidine kinase activity
KSP35_07500	COG0745	RESPONSE REGULATOR receiver
KSP35_07505	COG0714	Associated with various cellular activities
KSP35_07515	COG2304	oxidoreductase activity
KSP35_07540	COG1196	nuclear chromosome segregation
KSP35_07560	COG0571	ribonuclease III activity
KSP35_07590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KSP35_07605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KSP35_07610	COG0742	ribosomal rna small subunit methyltransferase
KSP35_07645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KSP35_07670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KSP35_07680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KSP35_07690	COG3103	Sh3 type 3 domain protein
KSP35_07690	COG0791	NLP P60 protein
KSP35_07690	COG1388	LysM domain
KSP35_07715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KSP35_07725	COG2197	response regulator
KSP35_07730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KSP35_07735	COG0596	Alpha beta hydrolase
KSP35_07740	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KSP35_07740	COG0825	malonyl-CoA metabolic process
KSP35_07750	COG0765	amino acid transport
KSP35_07790	COG0799	negative regulation of ribosome biogenesis
KSP35_07800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KSP35_07810	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KSP35_07820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KSP35_07825	COG0175	sulfate reduction
KSP35_07830	COG4122	O-methyltransferase activity
KSP35_07840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KSP35_07855	COG3387	PFAM Glycoside hydrolase 15-related
KSP35_07890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KSP35_07905	COG0464	growth
KSP35_07935	COG1842	Phage shock protein A
KSP35_07940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KSP35_07945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KSP35_07965	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KSP35_07970	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KSP35_07975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KSP35_07985	COG1530	ribonuclease E activity
KSP35_08000	COG0772	Belongs to the SEDS family
KSP35_08005	COG0768	penicillin binding
KSP35_08020	COG1077	Cell shape determining protein MreB Mrl
KSP35_08025	COG0105	UTP biosynthetic process
KSP35_08035	COG1595	DNA-templated transcription, initiation
KSP35_08050	COG0285	dihydrofolate synthase activity
KSP35_08065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KSP35_08070	COG0544	peptidyl-prolyl cis-trans isomerase activity
KSP35_08130	COG1136	(ABC) transporter
KSP35_08135	COG0577	efflux transmembrane transporter activity
KSP35_08135	COG1136	(ABC) transporter
KSP35_08160	COG1742	UPF0060 membrane protein
KSP35_08175	COG1876	peptidase activity
KSP35_08220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KSP35_08235	COG0740	serine-type endopeptidase activity
KSP35_08250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KSP35_08265	COG0745	RESPONSE REGULATOR receiver
KSP35_08270	COG2205	protein histidine kinase activity
KSP35_08300	COG0534	Mate efflux family protein
KSP35_08310	COG5001	Diguanylate cyclase
KSP35_08310	COG3706	GGDEF domain
KSP35_08310	COG4251	negative regulation of phosphorylation
KSP35_08310	COG2203	Gaf domain
KSP35_08335	COG0483	inositol monophosphate 1-phosphatase activity
KSP35_08350	COG1329	Transcriptional regulator
KSP35_08365	COG0183	Belongs to the thiolase family
KSP35_08375	COG2124	cytochrome p450
KSP35_08380	COG2177	Part of the ABC transporter FtsEX involved in
KSP35_08385	COG2884	Cell division ATP-binding protein ftsE
KSP35_08390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KSP35_08400	COG1132	(ABC) transporter
KSP35_08405	COG1126	abc transporter atp-binding protein
KSP35_08430	COG0697	spore germination
KSP35_08435	COG0653	protein targeting
KSP35_08445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KSP35_08450	COG1040	competence protein
KSP35_08455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KSP35_08470	COG0183	Belongs to the thiolase family
KSP35_08485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KSP35_08495	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_08515	COG2222	sugar isomerase
KSP35_08520	COG2835	tetraacyldisaccharide 4'-kinase activity
KSP35_08525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KSP35_08570	COG0438	transferase activity, transferring glycosyl groups
KSP35_08620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KSP35_08625	COG0438	transferase activity, transferring glycosyl groups
KSP35_08655	COG3540	Alkaline phosphatase
KSP35_08670	COG2268	Band 7 protein
KSP35_08745	COG1960	acyl-CoA dehydrogenase activity
KSP35_08800	COG1116	anion transmembrane transporter activity
KSP35_08805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KSP35_08820	COG3540	Alkaline phosphatase
KSP35_08835	COG4274	PFAM GYD family protein
KSP35_08850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KSP35_08860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KSP35_08870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KSP35_08875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KSP35_08895	COG0776	regulation of translation
KSP35_08920	COG1139	Iron-sulfur cluster binding protein
KSP35_08930	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KSP35_08935	COG1276	copper resistance
KSP35_08935	COG2372	response to copper ion
KSP35_08970	COG0395	ABC-type sugar transport system, permease component
KSP35_08975	COG1175	transmembrane transport
KSP35_09005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KSP35_09020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_09035	COG2197	response regulator
KSP35_09040	COG4585	Histidine kinase
KSP35_09050	COG1131	(ABC) transporter
KSP35_09095	COG1309	transcriptional regulator
KSP35_09100	COG1960	acyl-CoA dehydrogenase activity
KSP35_09110	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_09115	COG1764	response to oxidative stress
KSP35_09125	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KSP35_09135	COG1024	Enoyl-CoA hydratase
KSP35_09180	COG1960	acyl-CoA dehydrogenase activity
KSP35_09185	COG1960	acyl-CoA dehydrogenase activity
KSP35_09200	COG1024	Enoyl-CoA hydratase
KSP35_09235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KSP35_09300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KSP35_09320	COG0489	protein tyrosine kinase activity
KSP35_09325	COG1164	Oligoendopeptidase f
KSP35_09335	COG1960	acyl-CoA dehydrogenase activity
KSP35_09340	COG1960	acyl-CoA dehydrogenase activity
KSP35_09345	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KSP35_09380	COG0183	Belongs to the thiolase family
KSP35_09385	COG1595	DNA-templated transcription, initiation
KSP35_09450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KSP35_09455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KSP35_09470	COG0183	Belongs to the thiolase family
KSP35_09480	COG1960	acyl-CoA dehydrogenase activity
KSP35_09485	COG1960	acyl-CoA dehydrogenase activity
KSP35_09495	COG2070	2-Nitropropane dioxygenase
KSP35_09500	COG0456	acetyltransferase
KSP35_09520	COG1024	Enoyl-CoA hydratase
KSP35_09595	COG1960	acyl-CoA dehydrogenase activity
KSP35_09615	COG1215	transferase activity, transferring glycosyl groups
KSP35_09630	COG1132	(ABC) transporter
KSP35_09655	COG3300	MHYT domain
KSP35_09655	COG5001	Diguanylate cyclase
KSP35_09675	COG0640	Transcriptional regulator
KSP35_09705	COG0154	amidase activity
KSP35_09710	COG1024	Enoyl-CoA hydratase
KSP35_09735	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_09745	COG2321	neutral zinc metallopeptidase
KSP35_09750	COG1309	transcriptional regulator
KSP35_09780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KSP35_09790	COG1024	Enoyl-CoA hydratase
KSP35_09805	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_09810	COG1024	Enoyl-CoA hydratase
KSP35_09825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KSP35_09855	COG5002	protein histidine kinase activity
KSP35_09860	COG0745	RESPONSE REGULATOR receiver
KSP35_09900	COG0004	ammonium transporteR
KSP35_09915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KSP35_09920	COG0596	Alpha beta hydrolase
KSP35_09950	COG1183	phosphatidylcholine synthase activity
KSP35_09955	COG0688	phosphatidylethanolamine metabolic process
KSP35_09965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KSP35_09975	COG0473	3-isopropylmalate dehydrogenase activity
KSP35_09985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KSP35_10000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KSP35_10005	COG0066	3-isopropylmalate dehydratase activity
KSP35_10010	COG0702	epimerase
KSP35_10035	COG4260	virion core protein, lumpy skin disease virus
KSP35_10050	COG0436	Aminotransferase
KSP35_10055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KSP35_10075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KSP35_10120	COG4552	Acetyltransferase involved in intracellular survival and related
KSP35_10125	COG1309	transcriptional regulator
KSP35_10130	COG0477	Major facilitator Superfamily
KSP35_10140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KSP35_10145	COG0154	amidase activity
KSP35_10150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KSP35_10160	COG1595	DNA-templated transcription, initiation
KSP35_10175	COG1309	transcriptional regulator
KSP35_10185	COG0477	Major facilitator Superfamily
KSP35_10195	COG0515	serine threonine protein kinase
KSP35_10195	COG2815	serine threonine protein kinase
KSP35_10205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KSP35_10230	COG2226	methyltransferase
KSP35_10245	COG0482	sulfurtransferase activity
KSP35_10255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KSP35_10260	COG1085	galactose-1-phosphate uridylyltransferase
KSP35_10270	COG1408	metallophosphoesterase
KSP35_10295	COG0705	Rhomboid family
KSP35_10295	COG0457	Tetratricopeptide repeat
KSP35_10345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KSP35_10395	COG0714	Associated with various cellular activities
KSP35_10455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KSP35_10460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KSP35_10470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KSP35_10475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KSP35_10480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KSP35_10485	COG0356	it plays a direct role in the translocation of protons across the membrane
KSP35_10505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KSP35_10535	COG2890	protein-(glutamine-N5) methyltransferase activity
KSP35_10540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KSP35_10550	COG0254	rRNA binding
KSP35_10575	COG1132	(ABC) transporter
KSP35_10590	COG0477	Major facilitator Superfamily
KSP35_10610	COG0460	homoserine dehydrogenase
KSP35_10625	COG0018	arginyl-trna synthetase
KSP35_10630	COG0745	RESPONSE REGULATOR receiver
KSP35_10645	COG1309	transcriptional regulator
KSP35_10650	COG1316	TRANSCRIPTIONal
KSP35_10655	COG1960	acyl-CoA dehydrogenase activity
KSP35_10680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KSP35_10705	COG0561	phosphatase activity
KSP35_10710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KSP35_10710	COG1796	DNA polymerase
KSP35_10720	COG1174	glycine betaine transport
KSP35_10725	COG1174	glycine betaine transport
KSP35_10745	COG0515	serine threonine protein kinase
KSP35_10745	COG2815	serine threonine protein kinase
KSP35_10780	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_10820	COG4585	Histidine kinase
KSP35_10825	COG2197	response regulator
KSP35_10840	COG1024	Enoyl-CoA hydratase
KSP35_10855	COG1744	ABC transporter substrate-binding protein PnrA-like
KSP35_10860	COG3845	ABC transporter
KSP35_10865	COG1079	Belongs to the binding-protein-dependent transport system permease family
KSP35_10890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KSP35_10900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KSP35_10915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KSP35_10925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KSP35_10985	COG2340	Cysteine-rich secretory protein family
KSP35_10995	COG0315	cyclic pyranopterin monophosphate synthase activity
KSP35_11005	COG0303	'Molybdopterin
KSP35_11010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KSP35_11020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KSP35_11035	COG1968	undecaprenyl-diphosphatase activity
KSP35_11045	COG1376	ErfK ybiS ycfS ynhG family protein
KSP35_11050	COG1595	DNA-templated transcription, initiation
KSP35_11055	COG0312	modulator of DNA gyrase
KSP35_11060	COG0312	modulator of DNA gyrase
KSP35_11115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KSP35_11130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KSP35_11130	COG0316	Belongs to the HesB IscA family
KSP35_11140	COG0300	oxidoreductase activity
KSP35_11145	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_11170	COG0488	(ABC) transporter
KSP35_11175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KSP35_11185	COG0420	3'-5' exonuclease activity
KSP35_11190	COG0419	ATPase involved in DNA repair
KSP35_11195	COG0419	ATPase involved in DNA repair
KSP35_11205	COG1074	ATP-dependent DNA helicase activity
KSP35_11225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KSP35_11240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KSP35_11240	COG1703	isobutyryl-CoA mutase activity
KSP35_11240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KSP35_11320	COG2264	protein methyltransferase activity
KSP35_11350	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
KSP35_11385	COG1132	(ABC) transporter
KSP35_11390	COG1120	ATPase activity
KSP35_11395	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KSP35_11400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KSP35_11405	COG1309	transcriptional regulator
KSP35_11415	COG0535	radical SAM domain protein
KSP35_11435	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_11465	COG0183	Belongs to the thiolase family
KSP35_11480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KSP35_11485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KSP35_11530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KSP35_11540	COG1704	LemA family
KSP35_11550	COG0450	alkyl hydroperoxide reductase
KSP35_11555	COG1309	transcriptional regulator
KSP35_11580	COG1252	NADH dehydrogenase
KSP35_11585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KSP35_11595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KSP35_11605	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_11610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KSP35_11665	COG1215	transferase activity, transferring glycosyl groups
KSP35_11690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KSP35_11695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KSP35_11700	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KSP35_11710	COG1490	D-aminoacyl-tRNA deacylase activity
KSP35_11715	COG2822	iron ion transport
KSP35_11720	COG2837	iron assimilation
KSP35_11730	COG2226	methyltransferase
KSP35_11750	COG1946	Acyl-CoA thioesterase
KSP35_11765	COG1278	Cold shock
KSP35_11780	COG4335	DNA alkylation repair
KSP35_11785	COG1408	metallophosphoesterase
KSP35_11800	COG0129	dihydroxy-acid dehydratase activity
KSP35_11890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KSP35_11920	COG1051	belongs to the nudix hydrolase family
KSP35_11925	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KSP35_11935	COG0446	pyridine nucleotide-disulphide oxidoreductase
KSP35_12015	COG1606	tRNA processing
KSP35_12025	COG3253	May function as heme-dependent peroxidase
KSP35_12030	COG1674	ftsk spoiiie
KSP35_12040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KSP35_12040	COG2755	lipolytic protein G-D-S-L family
KSP35_12050	COG0477	Major facilitator Superfamily
KSP35_12055	COG0459	protein refolding
KSP35_12065	COG0463	Glycosyl transferase, family 2
KSP35_12080	COG0076	glutamate decarboxylase activity
KSP35_12100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KSP35_12115	COG3842	ATPase activity
KSP35_12140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_12185	COG2111	Na H antiporter
KSP35_12185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KSP35_12190	COG1006	Multisubunit Na H antiporter MnhC subunit
KSP35_12195	COG0651	ATP synthesis coupled electron transport
KSP35_12200	COG1863	multisubunit Na H antiporter MnhE subunit
KSP35_12205	COG2212	antiporter activity
KSP35_12225	COG1122	ATPase activity
KSP35_12240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KSP35_12240	COG1648	precorrin-2 dehydrogenase activity
KSP35_12260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KSP35_12260	COG1648	precorrin-2 dehydrogenase activity
KSP35_12300	COG1797	cobyrinic acid a,c-diamide synthase activity
KSP35_12330	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KSP35_12340	COG1492	cobalamin metabolic process
KSP35_12345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KSP35_12410	COG4581	dead DEAH box helicase
KSP35_12415	COG0714	Associated with various cellular activities
KSP35_12450	COG0640	Transcriptional regulator
KSP35_12465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KSP35_12485	COG0596	Alpha beta hydrolase
KSP35_12495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KSP35_12530	COG0477	Major facilitator Superfamily
KSP35_12550	COG1131	(ABC) transporter
KSP35_12565	COG0488	(ABC) transporter
KSP35_12570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KSP35_12580	COG0488	(ABC) transporter
KSP35_12590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KSP35_12595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KSP35_12600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KSP35_12605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KSP35_12610	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KSP35_12615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KSP35_12620	COG0783	Belongs to the Dps family
KSP35_12630	COG0142	geranyltranstransferase activity
KSP35_12650	COG1597	lipid kinase activity
KSP35_12655	COG2197	response regulator
KSP35_12660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KSP35_12675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KSP35_12685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KSP35_12705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KSP35_12710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KSP35_12715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KSP35_12725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KSP35_12740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KSP35_12745	COG0302	gtp cyclohydrolase
KSP35_12755	COG0037	tRNA processing
KSP35_12775	COG1595	DNA-templated transcription, initiation
KSP35_12785	COG2318	DinB family
KSP35_12820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KSP35_12825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KSP35_12845	COG0038	chloride channel
KSP35_12915	COG2205	protein histidine kinase activity
KSP35_12935	COG2197	response regulator
KSP35_12945	COG5001	Diguanylate cyclase
KSP35_13065	COG1216	Glycosyl transferase, family 2
KSP35_13070	COG0438	transferase activity, transferring glycosyl groups
KSP35_13125	COG0305	Participates in initiation and elongation during chromosome replication
KSP35_13170	COG3723	Recombinational DNA repair protein, rece pathway
KSP35_13245	COG1473	amidohydrolase
KSP35_13255	COG3268	Saccharopine dehydrogenase
KSP35_13275	COG1960	acyl-CoA dehydrogenase activity
KSP35_13285	COG3706	GGDEF domain
KSP35_13295	COG1132	(ABC) transporter
KSP35_13300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KSP35_13300	COG2199	diguanylate cyclase activity
KSP35_13335	COG3119	arylsulfatase activity
KSP35_13345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_13360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KSP35_13375	COG0038	chloride channel
KSP35_13405	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_13425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KSP35_13435	COG0477	Major facilitator Superfamily
KSP35_13485	COG0667	Aldo Keto reductase
KSP35_13490	COG0129	dihydroxy-acid dehydratase activity
KSP35_13495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KSP35_13500	COG1960	acyl-CoA dehydrogenase activity
KSP35_13505	COG1960	acyl-CoA dehydrogenase activity
KSP35_13545	COG0242	peptide deformylase activity
KSP35_13555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KSP35_13575	COG0604	alcohol dehydrogenase
KSP35_13575	COG3321	synthase
KSP35_13605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_13610	COG0154	amidase activity
KSP35_13620	COG1024	Enoyl-CoA hydratase
KSP35_13625	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_13635	COG2175	clavaminate synthase activity
KSP35_13640	COG1116	anion transmembrane transporter activity
KSP35_13645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KSP35_13650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KSP35_13655	COG0183	Belongs to the thiolase family
KSP35_13660	COG2050	protein possibly involved in aromatic compounds catabolism
KSP35_13665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KSP35_13670	COG1121	(ABC) transporter
KSP35_13690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KSP35_13690	COG0596	Alpha beta hydrolase
KSP35_13695	COG1733	regulation of RNA biosynthetic process
KSP35_13700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KSP35_13710	COG0784	Response regulator, receiver
KSP35_13715	COG4251	negative regulation of phosphorylation
KSP35_13730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KSP35_13745	COG1793	dna ligase
KSP35_13745	COG3285	dna ligase
KSP35_13750	COG2172	sigma factor antagonist activity
KSP35_13770	COG0756	dUTP diphosphatase activity
KSP35_13775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KSP35_13790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KSP35_13815	COG0693	protein deglycase activity
KSP35_13820	COG0259	pyridoxamine-phosphate oxidase activity
KSP35_13850	COG2211	Major facilitator Superfamily
KSP35_13900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KSP35_13920	COG0109	protoheme IX farnesyltransferase activity
KSP35_13930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KSP35_13975	COG0577	efflux transmembrane transporter activity
KSP35_13980	COG1136	(ABC) transporter
KSP35_13980	COG0577	efflux transmembrane transporter activity
KSP35_14040	COG0590	tRNA wobble adenosine to inosine editing
KSP35_14050	COG2226	methyltransferase
KSP35_14070	COG0494	nUDIX hydrolase
KSP35_14090	COG1116	anion transmembrane transporter activity
KSP35_14125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KSP35_14130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KSP35_14190	COG0590	tRNA wobble adenosine to inosine editing
KSP35_14220	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KSP35_14225	COG1309	transcriptional regulator
KSP35_14230	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KSP35_14240	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_14250	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_14260	COG2353	YceI-like domain
KSP35_14270	COG1132	(ABC) transporter
KSP35_14280	COG1570	exodeoxyribonuclease VII activity
KSP35_14285	COG1722	exodeoxyribonuclease VII activity
KSP35_14305	COG0142	geranyltranstransferase activity
KSP35_14360	COG1459	type II secretion system
KSP35_14365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KSP35_14370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KSP35_14380	COG0110	maltose O-acetyltransferase activity
KSP35_14390	COG0022	dehydrogenase e1 component
KSP35_14400	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_14410	COG0667	Aldo Keto reductase
KSP35_14440	COG0028	Belongs to the TPP enzyme family
KSP35_14445	COG0028	Belongs to the TPP enzyme family
KSP35_14455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KSP35_14465	COG0346	lactoylglutathione lyase activity
KSP35_14475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KSP35_14535	COG0346	lactoylglutathione lyase activity
KSP35_14565	COG2366	antibiotic biosynthetic process
KSP35_14570	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_14580	COG0590	tRNA wobble adenosine to inosine editing
KSP35_14585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KSP35_14595	COG2124	cytochrome p450
KSP35_14605	COG3300	MHYT domain
KSP35_14605	COG5001	Diguanylate cyclase
KSP35_14615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KSP35_14620	COG3361	conserved protein (COG2071)
KSP35_14630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSP35_14635	COG0386	Belongs to the glutathione peroxidase family
KSP35_14700	COG2409	Drug exporters of the RND superfamily
KSP35_14730	COG2890	protein-(glutamine-N5) methyltransferase activity
KSP35_14750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_14780	COG0745	RESPONSE REGULATOR receiver
KSP35_14790	COG5002	protein histidine kinase activity
KSP35_14805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KSP35_14810	COG0038	chloride channel
KSP35_14820	COG0004	ammonium transporteR
KSP35_14835	COG1320	monovalent cation:proton antiporter activity
KSP35_14850	COG0651	ATP synthesis coupled electron transport
KSP35_14855	COG1006	Multisubunit Na H antiporter MnhC subunit
KSP35_14860	COG2111	Na H antiporter
KSP35_14865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KSP35_14865	COG2111	Na H antiporter
KSP35_14885	COG1846	Transcriptional regulator
KSP35_14895	COG0667	Aldo Keto reductase
KSP35_14905	COG1116	anion transmembrane transporter activity
KSP35_14920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KSP35_14945	COG1024	Enoyl-CoA hydratase
KSP35_15015	COG0077	Prephenate dehydratase
KSP35_15020	COG1691	(AIR) carboxylase
KSP35_15025	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KSP35_15045	COG1357	PFAM Pentapeptide repeats (8 copies)
KSP35_15085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KSP35_15090	COG0531	amino acid
KSP35_15095	COG0531	amino acid
KSP35_15100	COG0569	domain protein
KSP35_15135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KSP35_15140	COG0477	Major facilitator Superfamily
KSP35_15155	COG1172	Belongs to the binding-protein-dependent transport system permease family
KSP35_15200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KSP35_15205	COG0183	Belongs to the thiolase family
KSP35_15245	COG0512	Glutamine amidotransferase of anthranilate synthase
KSP35_15250	COG2815	serine threonine protein kinase
KSP35_15250	COG0515	serine threonine protein kinase
KSP35_15265	COG0631	protein serine/threonine phosphatase activity
KSP35_15270	COG1716	ATPase activity
KSP35_15300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_15305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KSP35_15310	COG3706	GGDEF domain
KSP35_15350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KSP35_15385	COG1764	response to oxidative stress
KSP35_15390	COG1846	Transcriptional regulator
KSP35_15395	COG0671	phosphoesterase, PA-phosphatase related
KSP35_15435	COG2723	6-phospho-beta-galactosidase activity
KSP35_15450	COG1136	(ABC) transporter
KSP35_15465	COG2197	response regulator
KSP35_15480	COG3132	Protein of unknown function, DUF480
KSP35_15490	COG0366	Alpha amylase catalytic
KSP35_15500	COG3281	Trehalose synthase
KSP35_15505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KSP35_15550	COG0477	Major facilitator Superfamily
KSP35_15555	COG1309	transcriptional regulator
KSP35_15575	COG5001	Diguanylate cyclase
KSP35_15620	COG2239	Acts as a magnesium transporter
KSP35_15640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KSP35_15665	COG0187	DNA topoisomerase II activity
KSP35_15695	COG1191	sigma factor activity
KSP35_15725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KSP35_15730	COG0187	DNA topoisomerase II activity
KSP35_15740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KSP35_15745	COG0592	DNA-directed DNA polymerase activity
KSP35_15755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KSP35_15760	COG0594	ribonuclease P activity
KSP35_15765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KSP35_15770	COG0706	membrane insertase activity
KSP35_15775	COG1847	R3H domain protein
KSP35_15780	COG0357	Ribosomal RNA small subunit methyltransferase G
KSP35_15785	COG1192	Involved in chromosome partitioning
KSP35_15790	COG1475	DNA binding
KSP35_15800	COG0492	ferredoxin-NADP+ reductase activity
KSP35_15815	COG0515	serine threonine protein kinase
KSP35_15815	COG2815	serine threonine protein kinase
KSP35_15820	COG1307	EDD domain protein, DegV family
KSP35_15835	COG0456	acetyltransferase
KSP35_15840	COG0123	including yeast histone deacetylase and acetoin utilization protein
KSP35_15850	COG0617	tRNA 3'-terminal CCA addition
KSP35_15865	COG0667	Aldo Keto reductase
KSP35_15870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KSP35_15875	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KSP35_15890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KSP35_15900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KSP35_15910	COG0360	Binds together with S18 to 16S ribosomal RNA
KSP35_15920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KSP35_15930	COG0305	Participates in initiation and elongation during chromosome replication
KSP35_15935	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
KSP35_15970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KSP35_15975	COG2353	YceI-like domain
KSP35_16000	COG0596	Alpha beta hydrolase
KSP35_16010	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_16020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KSP35_16035	COG1960	acyl-CoA dehydrogenase activity
KSP35_16085	COG1131	(ABC) transporter
KSP35_16095	COG4941	Belongs to the sigma-70 factor family
KSP35_16100	COG3795	YCII-related domain
KSP35_16125	COG4941	Belongs to the sigma-70 factor family
KSP35_16195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KSP35_16225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KSP35_16260	COG0717	Belongs to the dCTP deaminase family
KSP35_16270	COG3872	metal-dependent enzyme
KSP35_16275	COG0745	RESPONSE REGULATOR receiver
KSP35_16280	COG0247	lactate metabolic process
KSP35_16280	COG2181	nitrate reductase activity
KSP35_16290	COG0588	phosphoglycerate mutase activity
KSP35_16300	COG0737	Belongs to the 5'-nucleotidase family
KSP35_16310	COG0737	Belongs to the 5'-nucleotidase family
KSP35_16315	COG0443	Heat shock 70 kDa protein
KSP35_16320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KSP35_16325	COG0484	heat shock protein binding
KSP35_16330	COG0789	Transcriptional regulator
KSP35_16335	COG0542	response to heat
KSP35_16355	COG0577	efflux transmembrane transporter activity
KSP35_16360	COG1136	(ABC) transporter
KSP35_16365	COG2197	response regulator
KSP35_16375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KSP35_16380	COG0151	Belongs to the GarS family
KSP35_16385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KSP35_16395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KSP35_16405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KSP35_16415	COG0047	phosphoribosylformylglycinamidine synthase activity
KSP35_16430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KSP35_16440	COG0424	maF-like protein
KSP35_16470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KSP35_16480	COG2909	trisaccharide binding
KSP35_16505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KSP35_16530	COG1192	Involved in chromosome partitioning
KSP35_16535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KSP35_16570	COG3467	pyridoxamine 5'-phosphate
KSP35_16585	COG1595	DNA-templated transcription, initiation
KSP35_16595	COG1660	Displays ATPase and GTPase activities
KSP35_16600	COG1309	transcriptional regulator
KSP35_16605	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_16625	COG2124	cytochrome p450
KSP35_16635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_16640	COG1472	Belongs to the glycosyl hydrolase 3 family
KSP35_16670	COG1122	ATPase activity
KSP35_16685	COG0310	cobalt ion transport
KSP35_16710	COG2070	2-Nitropropane dioxygenase
KSP35_16725	COG0586	Pfam SNARE associated Golgi protein
KSP35_16740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KSP35_16745	COG0140	phosphoribosyl-ATP diphosphatase activity
KSP35_16780	COG0778	Nitroreductase
KSP35_16825	COG1793	dna ligase
KSP35_16860	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_16870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KSP35_16895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KSP35_16915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KSP35_16915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KSP35_16925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KSP35_16930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KSP35_16955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KSP35_17000	COG1120	ATPase activity
KSP35_17065	COG2205	protein histidine kinase activity
KSP35_17065	COG0784	Response regulator, receiver
KSP35_17070	COG1366	Belongs to the anti-sigma-factor antagonist family
KSP35_17120	COG0740	serine-type endopeptidase activity
KSP35_17130	COG0640	Transcriptional regulator
KSP35_17150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KSP35_17170	COG0316	Belongs to the HesB IscA family
KSP35_17190	COG0251	oxidation-reduction process
KSP35_17205	COG0745	RESPONSE REGULATOR receiver
KSP35_17225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KSP35_17225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KSP35_17330	COG1111	helicase
KSP35_17330	COG1205	dead DEAH box helicase
KSP35_17335	COG1366	Belongs to the anti-sigma-factor antagonist family
KSP35_17340	COG2172	sigma factor antagonist activity
KSP35_17345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KSP35_17355	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_17400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KSP35_17405	COG1396	sequence-specific DNA binding
KSP35_17440	COG0406	alpha-ribazole phosphatase activity
KSP35_17465	COG0438	transferase activity, transferring glycosyl groups
KSP35_17515	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_17520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KSP35_17535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KSP35_17545	COG0181	hydroxymethylbilane synthase activity
KSP35_17560	COG2313	pseudouridylate synthase activity
KSP35_17570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KSP35_17575	COG0823	Involved in the tonB-independent uptake of proteins
KSP35_17575	COG1506	peptidase
KSP35_17575	COG4946	Tricorn protease homolog
KSP35_17590	COG0113	porphobilinogen synthase activity
KSP35_17595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KSP35_17600	COG5001	Diguanylate cyclase
KSP35_17610	COG0166	Belongs to the GPI family
KSP35_17615	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KSP35_17675	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSP35_17680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSP35_17685	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSP35_17690	COG0649	NAD binding
KSP35_17705	COG1034	ATP synthesis coupled electron transport
KSP35_17710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KSP35_17715	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSP35_17725	COG0713	ATP synthesis coupled electron transport
KSP35_17740	COG1007	ATP synthesis coupled electron transport
KSP35_17775	COG2755	lipolytic protein G-D-S-L family
KSP35_17775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KSP35_17780	COG1404	Belongs to the peptidase S8 family
KSP35_17790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSP35_17795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSP35_17800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSP35_17800	COG0649	NAD binding
KSP35_17810	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KSP35_17815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSP35_17825	COG0713	ATP synthesis coupled electron transport
KSP35_17830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KSP35_17840	COG1007	ATP synthesis coupled electron transport
KSP35_17850	COG0753	catalase activity
KSP35_17880	COG0477	Major facilitator Superfamily
KSP35_17890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KSP35_17900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KSP35_17915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KSP35_17920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KSP35_17950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KSP35_17955	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KSP35_17960	COG0402	S-adenosylhomocysteine deaminase activity
KSP35_17970	COG3964	amidohydrolase
KSP35_17985	COG4221	oxidoreductase activity
KSP35_18005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KSP35_18015	COG2814	Major facilitator Superfamily
KSP35_18040	COG1666	GTP binding
KSP35_18085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KSP35_18090	COG0051	transcription antitermination factor activity, RNA binding
KSP35_18120	COG0250	Participates in transcription elongation, termination and antitermination
KSP35_18125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KSP35_18130	COG0081	regulation of translation
KSP35_18135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KSP35_18140	COG0222	ribosome binding
KSP35_18145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KSP35_18160	COG2186	Transcriptional regulator
KSP35_18180	COG0085	RNA polymerase activity
KSP35_18185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KSP35_18190	COG0297	glycogen (starch) synthase activity
KSP35_18205	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KSP35_18220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KSP35_18225	COG0051	transcription antitermination factor activity, RNA binding
KSP35_18260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KSP35_18265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KSP35_18270	COG0438	transferase activity, transferring glycosyl groups
KSP35_18295	COG2274	protein secretion by the type I secretion system
KSP35_18305	COG2226	methyltransferase
KSP35_18310	COG2089	acid synthase
KSP35_18325	COG1083	cytidylyl-transferase
KSP35_18330	COG0489	protein tyrosine kinase activity
KSP35_18340	COG1216	Glycosyl transferase, family 2
KSP35_18365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KSP35_18375	COG2192	nodulation
KSP35_18410	COG0438	transferase activity, transferring glycosyl groups
KSP35_18445	COG2192	nodulation
KSP35_18480	COG0463	Glycosyl transferase, family 2
KSP35_18490	COG1134	teichoic acid transport
KSP35_18510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KSP35_18515	COG0088	Forms part of the polypeptide exit tunnel
KSP35_18520	COG0089	rRNA binding
KSP35_18525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KSP35_18530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KSP35_18540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KSP35_18545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KSP35_18550	COG0255	Belongs to the universal ribosomal protein uL29 family
KSP35_18555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KSP35_18560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KSP35_18565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KSP35_18570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KSP35_18580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KSP35_18585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KSP35_18590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KSP35_18595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KSP35_18600	COG1841	ribosomal large subunit assembly
KSP35_18605	COG0200	Binds to the 23S rRNA
KSP35_18615	COG0563	adenylate kinase activity
KSP35_18630	COG0477	Major facilitator Superfamily
KSP35_18640	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KSP35_18645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KSP35_18650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KSP35_18655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KSP35_18665	COG0203	ribosomal protein L17
KSP35_18675	COG1595	DNA-templated transcription, initiation
KSP35_18685	COG0101	tRNA pseudouridine synthase activity
KSP35_18690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_18705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KSP35_18710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KSP35_18715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KSP35_18725	COG0475	glutathione-regulated potassium exporter activity
KSP35_18730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KSP35_18735	COG0736	holo-[acyl-carrier-protein] synthase activity
KSP35_18745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KSP35_18745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KSP35_18750	COG0517	IMP dehydrogenase activity
KSP35_18755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KSP35_18760	COG2267	carboxylic ester hydrolase activity
KSP35_18765	COG0802	atpase or kinase
KSP35_18775	COG0456	acetyltransferase
KSP35_18780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KSP35_18795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KSP35_18800	COG0459	protein refolding
KSP35_18805	COG1309	transcriptional regulator
KSP35_18815	COG0494	nUDIX hydrolase
KSP35_18820	COG1678	Uncharacterized ACR, COG1678
KSP35_18830	COG0516	GMP reductase activity
KSP35_18830	COG0517	IMP dehydrogenase activity
KSP35_18845	COG0516	GMP reductase activity
KSP35_18875	COG0210	DNA helicase
KSP35_18880	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_18890	COG4221	oxidoreductase activity
KSP35_18895	COG0604	alcohol dehydrogenase
KSP35_18895	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_18895	COG3321	synthase
KSP35_18910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KSP35_18925	COG0138	bifunctional purine biosynthesis protein purh
KSP35_18930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KSP35_18935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KSP35_18945	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KSP35_18965	COG2072	flavoprotein involved in K transport
KSP35_18975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KSP35_19000	COG4981	capsule polysaccharide biosynthetic process
KSP35_19015	COG1136	(ABC) transporter
KSP35_19015	COG0577	efflux transmembrane transporter activity
KSP35_19040	COG0463	Glycosyl transferase, family 2
KSP35_19055	COG2226	methyltransferase
KSP35_19065	COG0500	methyltransferase
KSP35_19070	COG0586	Pfam SNARE associated Golgi protein
KSP35_19075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KSP35_19105	COG1231	oxidoreductase activity
KSP35_19115	COG2062	phosphohistidine phosphatase, SixA
KSP35_19130	COG1053	succinate dehydrogenase
KSP35_19150	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
KSP35_19155	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
KSP35_19190	COG0765	amino acid transport
KSP35_19195	COG0765	amino acid transport
KSP35_19200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KSP35_19230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KSP35_19250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KSP35_19260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KSP35_19270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KSP35_19280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KSP35_19285	COG0573	inorganic phosphate transmembrane transporter activity
KSP35_19290	COG0581	inorganic phosphate transmembrane transporter activity
KSP35_19295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KSP35_19300	COG0704	Plays a role in the regulation of phosphate uptake
KSP35_19305	COG0704	Plays a role in the regulation of phosphate uptake
KSP35_19310	COG5002	protein histidine kinase activity
KSP35_19320	COG2814	Major facilitator Superfamily
KSP35_19340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KSP35_19345	COG0314	molybdopterin synthase activity
KSP35_19355	COG1077	Cell shape determining protein MreB Mrl
KSP35_19385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KSP35_19390	COG0156	8-amino-7-oxononanoate synthase activity
KSP35_19395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KSP35_19415	COG3480	Lon protease (S16) C-terminal proteolytic domain
KSP35_19420	COG5002	protein histidine kinase activity
KSP35_19435	COG1615	UPF0182 protein
KSP35_19445	COG2801	Transposase and inactivated derivatives
KSP35_19445	COG3415	Transposase
KSP35_19455	COG0492	ferredoxin-NADP+ reductase activity
KSP35_19475	COG2409	Drug exporters of the RND superfamily
KSP35_19485	COG2124	cytochrome p450
KSP35_19500	COG0477	Major facilitator Superfamily
KSP35_19530	COG2124	cytochrome p450
KSP35_19540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KSP35_19625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_19645	COG1960	acyl-CoA dehydrogenase activity
KSP35_19700	COG5001	Diguanylate cyclase
KSP35_19700	COG3300	MHYT domain
KSP35_19705	COG4251	negative regulation of phosphorylation
KSP35_19705	COG5001	Diguanylate cyclase
KSP35_19705	COG2203	Gaf domain
KSP35_19705	COG3706	GGDEF domain
KSP35_19735	COG3384	dioxygenase
KSP35_19750	COG1285	pathogenesis
KSP35_19755	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KSP35_19765	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KSP35_19785	COG0450	alkyl hydroperoxide reductase
KSP35_19795	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KSP35_19975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KSP35_19980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KSP35_19985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KSP35_20000	COG0640	Transcriptional regulator
KSP35_20045	COG2217	Heavy metal translocating P-type atpase
KSP35_20055	COG1999	signal sequence binding
KSP35_20080	COG3794	PFAM blue (type 1) copper domain protein
KSP35_20100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KSP35_20115	COG1294	oxidase, subunit
KSP35_20120	COG1271	oxidase subunit
KSP35_20265	COG1937	Protein conserved in bacteria
KSP35_20270	COG2217	Heavy metal translocating P-type atpase
KSP35_20275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KSP35_20320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KSP35_20340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KSP35_20355	COG2132	Multicopper oxidase
KSP35_20365	COG0582	viral genome integration into host DNA
KSP35_20380	COG1131	(ABC) transporter
KSP35_20395	COG2909	trisaccharide binding
KSP35_20415	COG1131	(ABC) transporter
KSP35_20430	COG3903	Transcriptional regulator
KSP35_20430	COG3629	intracellular signal transduction
KSP35_20445	COG2409	Drug exporters of the RND superfamily
KSP35_20460	COG0789	Transcriptional regulator
KSP35_20475	COG5002	protein histidine kinase activity
KSP35_20475	COG2205	protein histidine kinase activity
KSP35_20475	COG0784	Response regulator, receiver
KSP35_20485	COG3706	GGDEF domain
KSP35_20520	COG0300	oxidoreductase activity
KSP35_20525	COG5001	Diguanylate cyclase
KSP35_20530	COG0154	amidase activity
KSP35_20535	COG1595	DNA-templated transcription, initiation
KSP35_20550	COG0242	peptide deformylase activity
KSP35_20555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KSP35_20605	COG3848	Pyruvate phosphate dikinase
KSP35_20605	COG0574	Belongs to the PEP-utilizing enzyme family
KSP35_20615	COG2354	Protein conserved in bacteria
KSP35_20640	COG2072	flavoprotein involved in K transport
KSP35_20670	COG2072	flavoprotein involved in K transport
KSP35_20680	COG0346	lactoylglutathione lyase activity
KSP35_20695	COG0346	lactoylglutathione lyase activity
KSP35_20700	COG0640	Transcriptional regulator
KSP35_20720	COG3119	arylsulfatase activity
KSP35_20760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KSP35_20765	COG0477	Major facilitator Superfamily
KSP35_20785	COG0543	2 iron, 2 sulfur cluster binding
KSP35_20785	COG0633	Ferredoxin
KSP35_20800	COG0154	amidase activity
KSP35_20810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KSP35_20830	COG0519	Catalyzes the synthesis of GMP from XMP
KSP35_20855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KSP35_20955	COG0667	Aldo Keto reductase
KSP35_21020	COG0346	lactoylglutathione lyase activity
KSP35_21030	COG2124	cytochrome p450
KSP35_21075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KSP35_21110	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KSP35_21175	COG2197	response regulator
KSP35_21190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KSP35_21215	COG1305	Transglutaminase-like
KSP35_21235	COG1131	(ABC) transporter
KSP35_21260	COG2409	Drug exporters of the RND superfamily
KSP35_21265	COG0668	transmembrane transport
KSP35_21280	COG0525	valine-tRNA ligase activity
KSP35_21285	COG0215	cysteine-tRNA ligase activity
KSP35_21305	COG1960	acyl-CoA dehydrogenase activity
KSP35_21310	COG2258	MOSC domain
KSP35_21325	COG0697	spore germination
KSP35_21345	COG0386	Belongs to the glutathione peroxidase family
KSP35_21370	COG0596	Alpha beta hydrolase
KSP35_21390	COG0515	serine threonine protein kinase
KSP35_21390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KSP35_21430	COG1472	Belongs to the glycosyl hydrolase 3 family
KSP35_21480	COG1131	(ABC) transporter
KSP35_21485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KSP35_21490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KSP35_21495	COG1959	2 iron, 2 sulfur cluster binding
KSP35_21500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_21505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSP35_21530	COG0655	NAD(P)H dehydrogenase (quinone) activity
KSP35_21575	COG0693	protein deglycase activity
KSP35_21575	COG0753	catalase activity
KSP35_21590	COG4251	negative regulation of phosphorylation
KSP35_21605	COG4221	oxidoreductase activity
KSP35_21625	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KSP35_21645	COG0427	acetyl-CoA hydrolase
KSP35_21660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KSP35_21660	COG2755	lipolytic protein G-D-S-L family
KSP35_21690	COG5001	Diguanylate cyclase
KSP35_21705	COG1309	transcriptional regulator
KSP35_21710	COG1960	acyl-CoA dehydrogenase activity
KSP35_21715	COG0243	molybdopterin cofactor binding
KSP35_21760	COG3123	guanosine phosphorylase activity
KSP35_21775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KSP35_21810	COG1733	regulation of RNA biosynthetic process
KSP35_21855	COG1309	transcriptional regulator
KSP35_21905	COG1024	Enoyl-CoA hydratase
KSP35_21910	COG0714	Associated with various cellular activities
KSP35_21920	COG1305	Transglutaminase-like
KSP35_21935	COG1024	Enoyl-CoA hydratase
KSP35_21940	COG3764	Sortase (surface protein transpeptidase)
KSP35_21955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KSP35_21970	COG1138	Cytochrome C-type biogenesis protein
KSP35_21980	COG3088	subunit of a heme lyase
KSP35_21995	COG1104	cysteine desulfurase activity
KSP35_22005	COG0222	ribosome binding
KSP35_22030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KSP35_22095	COG0584	glycerophosphoryl diester phosphodiesterase
KSP35_22130	COG1597	lipid kinase activity
KSP35_22150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KSP35_22160	COG0789	Transcriptional regulator
KSP35_22205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KSP35_22210	COG0084	hydrolase, TatD family'
KSP35_22220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KSP35_22255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KSP35_22260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KSP35_22270	COG1477	protein flavinylation
KSP35_22285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KSP35_22290	COG0193	aminoacyl-tRNA hydrolase activity
KSP35_22315	COG0583	DNA-binding transcription factor activity
KSP35_22335	COG3956	TIGRFAM MazG family protein
KSP35_22340	COG0148	phosphopyruvate hydratase activity
KSP35_22370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KSP35_22380	COG2205	protein histidine kinase activity
KSP35_22395	COG0745	RESPONSE REGULATOR receiver
KSP35_22410	COG0577	efflux transmembrane transporter activity
KSP35_22410	COG1136	(ABC) transporter
KSP35_22425	COG3384	dioxygenase
KSP35_22455	COG2144	transferase activity, transferring acyl groups
KSP35_22475	COG0438	transferase activity, transferring glycosyl groups
KSP35_22510	COG1063	alcohol dehydrogenase
KSP35_22530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KSP35_22560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KSP35_22570	COG3195	allantoin biosynthetic process
KSP35_22570	COG3648	Uricase
KSP35_22580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KSP35_22665	COG3467	pyridoxamine 5'-phosphate
KSP35_22700	COG0183	Belongs to the thiolase family
KSP35_22710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KSP35_22715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KSP35_22715	COG2755	lipolytic protein G-D-S-L family
KSP35_22735	COG0714	Associated with various cellular activities
KSP35_22750	COG2304	oxidoreductase activity
KSP35_22850	COG1733	regulation of RNA biosynthetic process
KSP35_22855	COG0702	epimerase
KSP35_22860	COG0702	epimerase
KSP35_22890	COG0477	Major facilitator Superfamily
KSP35_22910	COG2501	S4 domain
KSP35_22915	COG0435	Glutathione S-transferase
KSP35_22920	COG0789	Transcriptional regulator
KSP35_23005	COG0110	maltose O-acetyltransferase activity
KSP35_23040	COG0318	PFAM AMP-dependent synthetase and ligase
KSP35_23075	COG1234	tRNA 3'-trailer cleavage
KSP35_23080	COG1028	Short-chain dehydrogenase reductase Sdr
KSP35_23085	COG0346	lactoylglutathione lyase activity
KSP35_23110	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_23120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KSP35_23125	COG1793	dna ligase
KSP35_23135	COG0488	(ABC) transporter
KSP35_23140	COG1960	acyl-CoA dehydrogenase activity
KSP35_23170	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KSP35_23170	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KSP35_23190	COG0114	fumarate hydratase activity
KSP35_23210	COG1643	Atp-dependent helicase
KSP35_23275	COG2030	dehydratase
KSP35_23280	COG1194	a g-specific adenine glycosylase
KSP35_23285	COG0596	Alpha beta hydrolase
KSP35_23325	COG1132	(ABC) transporter
KSP35_23350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KSP35_23375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KSP35_23395	COG0667	Aldo Keto reductase
KSP35_23400	COG0719	Fe-S assembly protein
KSP35_23410	COG2133	pyrroloquinoline quinone binding
KSP35_23415	COG1072	(Pantothenic acid kinase))
KSP35_23420	COG2885	chlorophyll binding
KSP35_23440	COG0396	ATPase activity
KSP35_23450	COG2154	pterin-4-alpha-carbinolamine dehydratase
KSP35_23490	COG1393	Belongs to the ArsC family
KSP35_23495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KSP35_23500	COG0822	iron-sulfur transferase activity
KSP35_23505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KSP35_23510	COG0396	ATPase activity
KSP35_23520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KSP35_23525	COG1876	peptidase activity
KSP35_23545	COG1012	belongs to the aldehyde dehydrogenase family
KSP35_23555	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
KSP35_23565	COG1960	acyl-CoA dehydrogenase activity
KSP35_23605	COG1305	Transglutaminase-like
KSP35_23630	COG1136	(ABC) transporter
KSP35_23690	COG1970	mechanosensitive ion channel activity
KSP35_23725	COG1086	Polysaccharide biosynthesis protein
KSP35_23735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate