locus-tag	class	description
LH044_00015	COG0003	Pfam Anion-transporting ATPase
LH044_00035	COG0436	Aminotransferase
LH044_00065	COG0784	Response regulator, receiver
LH044_00065	COG2205	protein histidine kinase activity
LH044_00075	COG0745	RESPONSE REGULATOR receiver
LH044_00100	COG0438	transferase activity, transferring glycosyl groups
LH044_00100	COG0297	glycogen (starch) synthase activity
LH044_00105	COG1045	serine acetyltransferase
LH044_00110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LH044_00130	COG0714	Associated with various cellular activities
LH044_00160	COG2001	Belongs to the MraZ family
LH044_00165	COG0275	rRNA processing
LH044_00180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH044_00185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH044_00190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LH044_00195	COG0772	Belongs to the SEDS family
LH044_00210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LH044_00215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH044_00220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LH044_00225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LH044_00230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LH044_00240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH044_00245	COG1799	cell septum assembly
LH044_00260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LH044_00265	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LH044_00270	COG0564	pseudouridine synthase activity
LH044_00280	COG1959	2 iron, 2 sulfur cluster binding
LH044_00305	COG0778	Nitroreductase
LH044_00315	COG1331	Highly conserved protein containing a thioredoxin domain
LH044_00330	COG4977	sequence-specific DNA binding
LH044_00375	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LH044_00385	COG1169	isochorismate synthase
LH044_00390	COG2226	methyltransferase
LH044_00410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_00425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LH044_00430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH044_00455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LH044_00460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH044_00465	COG0131	Imidazoleglycerol-phosphate dehydratase
LH044_00470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LH044_00475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LH044_00480	COG0107	imidazoleglycerol-phosphate synthase activity
LH044_00490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH044_00510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LH044_00510	COG0140	phosphoribosyl-ATP diphosphatase activity
LH044_00520	COG0354	folic acid binding
LH044_00530	COG0640	Transcriptional regulator
LH044_00545	COG0134	indole-3-glycerol-phosphate synthase activity
LH044_00550	COG0135	phosphoribosylanthranilate isomerase activity
LH044_00555	COG0133	tryptophan synthase activity
LH044_00560	COG0159	tryptophan synthase activity
LH044_00565	COG0776	regulation of translation
LH044_00570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH044_00580	COG0402	S-adenosylhomocysteine deaminase activity
LH044_00610	COG1595	DNA-templated transcription, initiation
LH044_00620	COG0702	epimerase
LH044_00625	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_00665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH044_00675	COG0539	negative regulation of cytoplasmic translation
LH044_00735	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH044_00740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LH044_00750	COG0484	heat shock protein binding
LH044_00820	COG2197	response regulator
LH044_00850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LH044_00855	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_00860	COG3842	ATPase activity
LH044_00865	COG1178	ABC-type Fe3 transport system permease component
LH044_00885	COG4214	carbohydrate transport
LH044_00910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH044_00960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH044_00970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LH044_00985	COG1960	acyl-CoA dehydrogenase activity
LH044_00990	COG3158	transport of potassium into the cell
LH044_00995	COG1564	THIamine pyrophosphokinase
LH044_01005	COG4149	molybdate abc transporter
LH044_01020	COG1119	ATPase activity
LH044_01035	COG1253	flavin adenine dinucleotide binding
LH044_01055	COG0215	cysteine-tRNA ligase activity
LH044_01070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LH044_01085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LH044_01090	COG1560	Kdo2-lipid A biosynthetic process
LH044_01095	COG0438	transferase activity, transferring glycosyl groups
LH044_01100	COG0501	Belongs to the peptidase M48B family
LH044_01110	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LH044_01115	COG0217	transcriptional regulatory protein
LH044_01120	COG0450	alkyl hydroperoxide reductase
LH044_01135	COG4555	ABC transporter
LH044_01140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LH044_01145	COG0632	four-way junction helicase activity
LH044_01150	COG2255	four-way junction helicase activity
LH044_01170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH044_01175	COG0343	queuine tRNA-ribosyltransferase activity
LH044_01190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH044_01195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH044_01225	COG0124	histidyl-tRNA synthetase
LH044_01230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LH044_01260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH044_01265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LH044_01270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LH044_01275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH044_01290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH044_01305	COG0006	proline dipeptidase activity
LH044_01310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH044_01315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH044_01320	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LH044_01325	COG0540	Belongs to the ATCase OTCase family
LH044_01330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH044_01335	COG0505	Belongs to the CarA family
LH044_01345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH044_01350	COG0167	dihydroorotate dehydrogenase activity
LH044_01355	COG0284	orotidine-5'-phosphate decarboxylase activity
LH044_01365	COG0194	GDP metabolic process
LH044_01370	COG1758	RNA polymerase activity
LH044_01380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH044_01390	COG2813	Specifically methylates the guanine in position
LH044_01395	COG0242	peptide deformylase activity
LH044_01400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LH044_01405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH044_01410	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH044_01415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH044_01415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH044_01425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LH044_01425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LH044_01430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LH044_01440	COG5001	Diguanylate cyclase
LH044_01455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LH044_01475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LH044_01480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LH044_01485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH044_01490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LH044_01495	COG0072	phenylalanine-tRNA ligase activity
LH044_01495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH044_01500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LH044_01505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH044_01510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LH044_01515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LH044_01525	COG0137	argininosuccinate synthase activity
LH044_01530	COG0165	Argininosuccinate lyase
LH044_01555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LH044_01585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH044_01585	COG2755	lipolytic protein G-D-S-L family
LH044_01590	COG3588	fructose-bisphosphate aldolase
LH044_01605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LH044_01610	COG0497	DNA recombination
LH044_01630	COG0438	transferase activity, transferring glycosyl groups
LH044_01645	COG0584	glycerophosphoryl diester phosphodiesterase
LH044_01650	COG0504	CTP synthase activity
LH044_01655	COG0494	nUDIX hydrolase
LH044_01670	COG0180	Tryptophanyl-tRNA synthetase
LH044_01680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LH044_01685	COG1187	pseudouridine synthase activity
LH044_01695	COG0287	Prephenate dehydrogenase
LH044_01700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LH044_01720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LH044_01735	COG1160	GTP binding
LH044_01745	COG0545	Peptidyl-prolyl cis-trans isomerase
LH044_01750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LH044_01765	COG0582	viral genome integration into host DNA
LH044_01810	COG1525	nuclease
LH044_01900	COG3654	unkown
LH044_01925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH044_01970	COG2226	methyltransferase
LH044_02005	COG0702	epimerase
LH044_02030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH044_02035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LH044_02065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH044_02070	COG0463	Glycosyl transferase, family 2
LH044_02075	COG2135	peptidase activity
LH044_02090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LH044_02095	COG0509	glycine decarboxylation via glycine cleavage system
LH044_02120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LH044_02125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH044_02125	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH044_02180	COG0424	maF-like protein
LH044_02210	COG1678	Uncharacterized ACR, COG1678
LH044_02215	COG1012	belongs to the aldehyde dehydrogenase family
LH044_02230	COG1072	(Pantothenic acid kinase))
LH044_02250	COG1960	acyl-CoA dehydrogenase activity
LH044_02255	COG1960	acyl-CoA dehydrogenase activity
LH044_02280	COG1024	Enoyl-CoA hydratase
LH044_02310	COG1473	amidohydrolase
LH044_02325	COG4581	dead DEAH box helicase
LH044_02345	COG0584	glycerophosphoryl diester phosphodiesterase
LH044_02350	COG0681	Belongs to the peptidase S26 family
LH044_02375	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LH044_02380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LH044_02385	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LH044_02395	COG4122	O-methyltransferase activity
LH044_02410	COG1222	aaa ATPase
LH044_02435	COG0037	tRNA processing
LH044_02465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LH044_02495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LH044_02500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH044_02515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LH044_02530	COG1611	Belongs to the LOG family
LH044_02550	COG2255	four-way junction helicase activity
LH044_02565	COG0366	Alpha amylase catalytic
LH044_02580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LH044_02610	COG1752	Esterase of the alpha-beta hydrolase superfamily
LH044_02615	COG0596	Alpha beta hydrolase
LH044_02620	COG0469	pyruvate kinase activity
LH044_02625	COG1960	acyl-CoA dehydrogenase activity
LH044_02635	COG2912	Transglutaminase-like superfamily
LH044_02640	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_02665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH044_02670	COG0444	Belongs to the ABC transporter superfamily
LH044_02675	COG4608	Belongs to the ABC transporter superfamily
LH044_02710	COG1136	(ABC) transporter
LH044_02725	COG4585	Histidine kinase
LH044_02730	COG3813	Protein conserved in bacteria
LH044_02735	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LH044_02770	COG0463	Glycosyl transferase, family 2
LH044_02795	COG2226	methyltransferase
LH044_02805	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
LH044_02815	COG0492	ferredoxin-NADP+ reductase activity
LH044_02830	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_02850	COG0070	glutamate synthase
LH044_02850	COG0067	glutamate synthase
LH044_02850	COG0069	glutamate synthase activity
LH044_02860	COG1362	aminopeptidase activity
LH044_02865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH044_02880	COG0657	acetylesterase activity
LH044_02895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH044_02905	COG1316	TRANSCRIPTIONal
LH044_02930	COG1012	belongs to the aldehyde dehydrogenase family
LH044_02935	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_02945	COG3527	Alpha-acetolactate decarboxylase
LH044_02950	COG0174	glutamine synthetase
LH044_02955	COG0243	molybdopterin cofactor binding
LH044_02965	COG0427	acetyl-CoA hydrolase
LH044_02985	COG0028	Belongs to the TPP enzyme family
LH044_02990	COG0726	polysaccharide deacetylase
LH044_03000	COG3804	dihydrodipicolinate reductase
LH044_03010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH044_03055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_03070	COG0765	amino acid transport
LH044_03105	COG0596	Alpha beta hydrolase
LH044_03120	COG2847	Copper chaperone PCu(A)C
LH044_03125	COG1999	signal sequence binding
LH044_03135	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LH044_03150	COG0842	Transport permease protein
LH044_03150	COG1129	ABC transporter
LH044_03160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LH044_03180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_03220	COG0435	Glutathione S-transferase
LH044_03225	COG0832	Belongs to the urease beta subunit family
LH044_03225	COG0831	urea catabolic process
LH044_03230	COG0804	urea catabolic process
LH044_03235	COG0830	nickel cation binding
LH044_03240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LH044_03300	COG1960	acyl-CoA dehydrogenase activity
LH044_03305	COG4988	ABC transporter
LH044_03310	COG0402	S-adenosylhomocysteine deaminase activity
LH044_03320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LH044_03325	COG0277	FAD linked oxidase domain protein
LH044_03335	COG3119	arylsulfatase activity
LH044_03340	COG0596	Alpha beta hydrolase
LH044_03350	COG0697	spore germination
LH044_03360	COG3284	Transcriptional regulator
LH044_03405	COG0667	Aldo Keto reductase
LH044_03410	COG1323	Belongs to the UPF0348 family
LH044_03415	COG1309	transcriptional regulator
LH044_03420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH044_03435	COG2072	flavoprotein involved in K transport
LH044_03440	COG1132	(ABC) transporter
LH044_03445	COG0789	Transcriptional regulator
LH044_03450	COG4221	oxidoreductase activity
LH044_03455	COG1252	NADH dehydrogenase
LH044_03460	COG0243	molybdopterin cofactor binding
LH044_03480	COG0572	uridine kinase
LH044_03485	COG3012	SEC-C Motif Domain Protein
LH044_03550	COG1024	Enoyl-CoA hydratase
LH044_03570	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_03580	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_03595	COG1012	belongs to the aldehyde dehydrogenase family
LH044_03605	COG1309	transcriptional regulator
LH044_03615	COG1960	acyl-CoA dehydrogenase activity
LH044_03620	COG1960	acyl-CoA dehydrogenase activity
LH044_03645	COG0411	ABC transporter
LH044_03655	COG2301	Belongs to the HpcH HpaI aldolase family
LH044_03660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_03685	COG4638	Rieske (2fe-2S)
LH044_03695	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_03710	COG1960	acyl-CoA dehydrogenase activity
LH044_03730	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_03755	COG1960	acyl-CoA dehydrogenase activity
LH044_03770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_03780	COG0183	Belongs to the thiolase family
LH044_03785	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_03800	COG1960	acyl-CoA dehydrogenase activity
LH044_03805	COG1960	acyl-CoA dehydrogenase activity
LH044_03820	COG1024	Enoyl-CoA hydratase
LH044_03850	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_03860	COG1960	acyl-CoA dehydrogenase activity
LH044_03865	COG1802	Transcriptional regulator
LH044_03870	COG1024	Enoyl-CoA hydratase
LH044_03885	COG1960	acyl-CoA dehydrogenase activity
LH044_03890	COG1960	acyl-CoA dehydrogenase activity
LH044_03900	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_03905	COG2267	carboxylic ester hydrolase activity
LH044_03925	COG1414	Transcriptional regulator
LH044_03930	COG3971	2-oxopent-4-enoate hydratase activity
LH044_03935	COG0346	lactoylglutathione lyase activity
LH044_03940	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LH044_03950	COG1053	succinate dehydrogenase
LH044_03970	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_03980	COG0022	dehydrogenase e1 component
LH044_04005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH044_04020	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_04035	COG0006	proline dipeptidase activity
LH044_04045	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LH044_04050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_04055	COG1053	succinate dehydrogenase
LH044_04100	COG0110	maltose O-acetyltransferase activity
LH044_04130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH044_04165	COG2357	RelA SpoT domain protein
LH044_04185	COG0671	phosphoesterase, PA-phosphatase related
LH044_04190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH044_04195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH044_04200	COG0149	triose-phosphate isomerase activity
LH044_04205	COG0126	phosphoglycerate kinase activity
LH044_04210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LH044_04215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LH044_04220	COG1660	Displays ATPase and GTPase activities
LH044_04230	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LH044_04235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH044_04240	COG0322	excinuclease ABC activity
LH044_04250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LH044_04260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH044_04265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LH044_04270	COG0556	nucleotide-excision repair
LH044_04275	COG0237	dephospho-CoA kinase activity
LH044_04285	COG2197	response regulator
LH044_04310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LH044_04345	COG1960	acyl-CoA dehydrogenase activity
LH044_04360	COG0243	molybdopterin cofactor binding
LH044_04365	COG0596	Alpha beta hydrolase
LH044_04365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH044_04395	COG0514	ATP-dependent DNA helicase (RecQ)
LH044_04430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH044_04440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH044_04450	COG0513	Belongs to the DEAD box helicase family
LH044_04480	COG1329	Transcriptional regulator
LH044_04515	COG0745	RESPONSE REGULATOR receiver
LH044_04520	COG2205	protein histidine kinase activity
LH044_04535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH044_04545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LH044_04560	COG2171	N-acyltransferase activity
LH044_04565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH044_04580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH044_04585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LH044_04590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH044_04605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LH044_04610	COG1546	Belongs to the CinA family
LH044_04610	COG1058	Belongs to the CinA family
LH044_04620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH044_04645	COG1674	ftsk spoiiie
LH044_04645	COG1674	ftsk spoiiie
LH044_04655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_04670	COG2409	Drug exporters of the RND superfamily
LH044_04675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LH044_04680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH044_04710	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_04720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LH044_04730	COG3830	Belongs to the UPF0237 family
LH044_04730	COG0560	Phosphoserine phosphatase
LH044_04735	COG0612	Peptidase, M16
LH044_04740	COG1185	polyribonucleotide nucleotidyltransferase activity
LH044_04745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LH044_04755	COG0196	riboflavin kinase activity
LH044_04760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH044_04765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LH044_04780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH044_04795	COG0195	Participates in both transcription termination and antitermination
LH044_04800	COG0195	Participates in both transcription termination and antitermination
LH044_04810	COG0779	Required for maturation of 30S ribosomal subunits
LH044_04815	COG0442	prolyl-tRNA aminoacylation
LH044_04825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LH044_04835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LH044_04840	COG0575	Belongs to the CDS family
LH044_04845	COG0233	cytoplasmic translational termination
LH044_04850	COG0528	UMP kinase activity
LH044_04855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LH044_04860	COG0052	Belongs to the universal ribosomal protein uS2 family
LH044_04870	COG1191	sigma factor activity
LH044_04875	COG4974	Belongs to the 'phage' integrase family
LH044_04880	COG0758	DNA mediated transformation
LH044_04895	COG0792	nuclease activity
LH044_04900	COG0335	large ribosomal subunit rRNA binding
LH044_04910	COG0336	Belongs to the RNA methyltransferase TrmD family
LH044_04915	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LH044_04920	COG1837	Belongs to the UPF0109 family
LH044_04925	COG0228	four-way junction DNA binding
LH044_04935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LH044_04950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LH044_04965	COG0552	protein localization to endoplasmic reticulum
LH044_04970	COG0714	Associated with various cellular activities
LH044_04980	COG2304	oxidoreductase activity
LH044_04990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH044_04995	COG0571	ribonuclease III activity
LH044_05000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH044_05005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LH044_05020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LH044_05025	COG0742	ribosomal rna small subunit methyltransferase
LH044_05035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LH044_05050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LH044_05060	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LH044_05065	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LH044_05070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LH044_05070	COG1473	amidohydrolase
LH044_05090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LH044_05095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_05115	COG1085	galactose-1-phosphate uridylyltransferase
LH044_05120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LH044_05150	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH044_05150	COG0567	Dehydrogenase, E1 component
LH044_05155	COG1011	Hydrolase
LH044_05165	COG0488	(ABC) transporter
LH044_05180	COG0529	Catalyzes the synthesis of activated sulfate
LH044_05195	COG1218	3'(2'),5'-bisphosphate nucleotidase
LH044_05205	COG1217	gtp-binding protein TYPA
LH044_05215	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LH044_05220	COG2030	dehydratase
LH044_05225	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_05240	COG0667	Aldo Keto reductase
LH044_05245	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LH044_05255	COG2070	2-Nitropropane dioxygenase
LH044_05265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_05275	COG1091	dTDP-4-dehydrorhamnose reductase activity
LH044_05280	COG1960	acyl-CoA dehydrogenase activity
LH044_05305	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_05315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH044_05315	COG2755	lipolytic protein G-D-S-L family
LH044_05320	COG1960	acyl-CoA dehydrogenase activity
LH044_05355	COG0477	Major facilitator Superfamily
LH044_05415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_05425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH044_05430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_05435	COG1472	Belongs to the glycosyl hydrolase 3 family
LH044_05445	COG0076	glutamate decarboxylase activity
LH044_05455	COG0183	Belongs to the thiolase family
LH044_05460	COG1525	nuclease
LH044_05470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LH044_05495	COG1960	acyl-CoA dehydrogenase activity
LH044_05515	COG0587	DNA-directed DNA polymerase activity
LH044_05520	COG3548	integral membrane protein
LH044_05535	COG5001	Diguanylate cyclase
LH044_05535	COG3300	MHYT domain
LH044_05540	COG2205	protein histidine kinase activity
LH044_05545	COG0745	RESPONSE REGULATOR receiver
LH044_05600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LH044_05610	COG0383	alpha-mannosidase activity
LH044_05620	COG2124	cytochrome p450
LH044_05635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH044_05645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LH044_05660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH044_05665	COG0537	adenosine 5'-monophosphoramidase activity
LH044_05680	COG3842	ATPase activity
LH044_05690	COG0395	ABC-type sugar transport system, permease component
LH044_05700	COG0277	FAD linked oxidase domain protein
LH044_05705	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LH044_05715	COG0009	L-threonylcarbamoyladenylate synthase
LH044_05720	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_05760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH044_05825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH044_05830	COG1960	acyl-CoA dehydrogenase activity
LH044_05865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH044_05890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH044_05895	COG1376	ErfK ybiS ycfS ynhG family protein
LH044_05905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH044_05915	COG0473	3-isopropylmalate dehydrogenase activity
LH044_05920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH044_05925	COG1970	mechanosensitive ion channel activity
LH044_05930	COG0248	Ppx GppA phosphatase
LH044_05935	COG1162	GTPase activity
LH044_05945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LH044_05950	COG0066	3-isopropylmalate dehydratase activity
LH044_05975	COG0436	Aminotransferase
LH044_05980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LH044_05985	COG0475	glutathione-regulated potassium exporter activity
LH044_05990	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_05995	COG5002	protein histidine kinase activity
LH044_06005	COG0745	RESPONSE REGULATOR receiver
LH044_06010	COG0004	ammonium transporteR
LH044_06015	COG0004	ammonium transporteR
LH044_06040	COG0083	homoserine kinase activity
LH044_06045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LH044_06050	COG0577	efflux transmembrane transporter activity
LH044_06060	COG0440	acetolactate synthase activity
LH044_06065	COG0028	Belongs to the TPP enzyme family
LH044_06080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LH044_06085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LH044_06090	COG1253	flavin adenine dinucleotide binding
LH044_06095	COG0129	dihydroxy-acid dehydratase activity
LH044_06110	COG1131	(ABC) transporter
LH044_06125	COG0534	Mate efflux family protein
LH044_06130	COG4552	Acetyltransferase involved in intracellular survival and related
LH044_06145	COG1595	DNA-templated transcription, initiation
LH044_06155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH044_06160	COG0154	amidase activity
LH044_06165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH044_06200	COG0477	Major facilitator Superfamily
LH044_06205	COG0515	serine threonine protein kinase
LH044_06205	COG2815	serine threonine protein kinase
LH044_06215	COG1011	Hydrolase
LH044_06220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH044_06235	COG0482	sulfurtransferase activity
LH044_06250	COG1960	acyl-CoA dehydrogenase activity
LH044_06275	COG0714	Associated with various cellular activities
LH044_06295	COG2226	methyltransferase
LH044_06305	COG0457	Tetratricopeptide repeat
LH044_06305	COG0705	Rhomboid family
LH044_06310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LH044_06315	COG3281	Trehalose synthase
LH044_06320	COG2755	lipolytic protein G-D-S-L family
LH044_06320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH044_06335	COG0366	Alpha amylase catalytic
LH044_06345	COG0058	SHG alpha-glucan phosphorylase activity
LH044_06370	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LH044_06375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LH044_06415	COG1191	sigma factor activity
LH044_06425	COG4786	Flagellar basal body rod
LH044_06425	COG1256	bacterial-type flagellum assembly
LH044_06440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LH044_06465	COG1677	Flagellar hook-basal body complex protein FliE
LH044_06470	COG1766	The M ring may be actively involved in energy transduction
LH044_06475	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH044_06485	COG1157	protein secretion by the type III secretion system
LH044_06495	COG1196	nuclear chromosome segregation
LH044_06495	COG0739	heme binding
LH044_06495	COG0741	lytic transglycosylase activity
LH044_06520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LH044_06535	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH044_06540	COG1776	CheC inhibitor of MCP methylation
LH044_06540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH044_06550	COG1338	Plays a role in the flagellum-specific transport system
LH044_06555	COG1987	bacterial-type flagellum assembly
LH044_06565	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH044_06570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH044_06580	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
LH044_06585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LH044_06590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LH044_06595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LH044_06600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LH044_06605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH044_06615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH044_06620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH044_06625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH044_06630	COG0356	it plays a direct role in the translocation of protons across the membrane
LH044_06685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LH044_06690	COG0698	ribose 5-phosphate isomerase
LH044_06695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH044_06695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH044_06705	COG2890	protein-(glutamine-N5) methyltransferase activity
LH044_06710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LH044_06730	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
LH044_06745	COG0460	homoserine dehydrogenase
LH044_06755	COG0018	arginyl-trna synthetase
LH044_06770	COG1121	(ABC) transporter
LH044_06775	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH044_06780	COG1316	TRANSCRIPTIONal
LH044_06785	COG1960	acyl-CoA dehydrogenase activity
LH044_06840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LH044_06875	COG2894	cell division
LH044_06880	COG0003	Pfam Anion-transporting ATPase
LH044_06920	COG0489	protein tyrosine kinase activity
LH044_06920	COG2151	metal-sulfur cluster biosynthetic enzyme
LH044_06925	COG0154	amidase activity
LH044_06930	COG1335	isochorismatase
LH044_06945	COG1079	Belongs to the binding-protein-dependent transport system permease family
LH044_06955	COG3845	ABC transporter
LH044_06975	COG1104	cysteine desulfurase activity
LH044_06990	COG0406	alpha-ribazole phosphatase activity
LH044_07020	COG3088	subunit of a heme lyase
LH044_07025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH044_07030	COG1138	Cytochrome C-type biogenesis protein
LH044_07035	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LH044_07050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LH044_07065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LH044_07095	COG1674	ftsk spoiiie
LH044_07115	COG1309	transcriptional regulator
LH044_07125	COG0531	amino acid
LH044_07215	COG1595	DNA-templated transcription, initiation
LH044_07220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH044_07240	COG1960	acyl-CoA dehydrogenase activity
LH044_07255	COG0215	cysteine-tRNA ligase activity
LH044_07260	COG2199	diguanylate cyclase activity
LH044_07270	COG0525	valine-tRNA ligase activity
LH044_07285	COG0668	transmembrane transport
LH044_07290	COG5001	Diguanylate cyclase
LH044_07290	COG3300	MHYT domain
LH044_07310	COG0427	acetyl-CoA hydrolase
LH044_07350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH044_07350	COG0574	Belongs to the PEP-utilizing enzyme family
LH044_07355	COG2267	carboxylic ester hydrolase activity
LH044_07360	COG0438	transferase activity, transferring glycosyl groups
LH044_07425	COG1136	(ABC) transporter
LH044_07425	COG0577	efflux transmembrane transporter activity
LH044_07430	COG0577	efflux transmembrane transporter activity
LH044_07430	COG1136	(ABC) transporter
LH044_07450	COG2957	Belongs to the agmatine deiminase family
LH044_07460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LH044_07465	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LH044_07500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH044_07505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH044_07510	COG1120	ATPase activity
LH044_07555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH044_07560	COG2351	hydroxyisourate hydrolase activity
LH044_07565	COG3195	allantoin biosynthetic process
LH044_07565	COG3648	Uricase
LH044_07580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LH044_07585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH044_07640	COG2124	cytochrome p450
LH044_07645	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_07705	COG0657	acetylesterase activity
LH044_07710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LH044_07715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_07740	COG3845	ABC transporter
LH044_07750	COG2197	response regulator
LH044_07760	COG4585	Histidine kinase
LH044_07765	COG2197	response regulator
LH044_07780	COG1408	metallophosphoesterase
LH044_07785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH044_07835	COG4221	oxidoreductase activity
LH044_07855	COG1024	Enoyl-CoA hydratase
LH044_07875	COG3842	ATPase activity
LH044_07890	COG2197	response regulator
LH044_07935	COG1058	Belongs to the CinA family
LH044_07935	COG1546	Belongs to the CinA family
LH044_07950	COG2197	response regulator
LH044_07955	COG4566	intracellular signal transduction
LH044_07960	COG4251	negative regulation of phosphorylation
LH044_07965	COG0784	Response regulator, receiver
LH044_08030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_08035	COG5002	protein histidine kinase activity
LH044_08040	COG2201	protein-glutamate methylesterase activity
LH044_08100	COG0859	PFAM glycosyl transferase family 9
LH044_08105	COG0438	transferase activity, transferring glycosyl groups
LH044_08115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LH044_08115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LH044_08120	COG4221	oxidoreductase activity
LH044_08150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH044_08155	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LH044_08160	COG2192	nodulation
LH044_08180	COG0723	plastoquinol--plastocyanin reductase activity
LH044_08185	COG0745	RESPONSE REGULATOR receiver
LH044_08190	COG1191	sigma factor activity
LH044_08210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LH044_08305	COG1295	ribonuclease BN
LH044_08320	COG4251	negative regulation of phosphorylation
LH044_08325	COG1366	Belongs to the anti-sigma-factor antagonist family
LH044_08330	COG3387	PFAM Glycoside hydrolase 15-related
LH044_08335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_08345	COG1191	sigma factor activity
LH044_08350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LH044_08395	COG1230	cation diffusion facilitator family transporter
LH044_08400	COG1742	UPF0060 membrane protein
LH044_08425	COG0783	Belongs to the Dps family
LH044_08445	COG0183	Belongs to the thiolase family
LH044_08475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH044_08510	COG2200	EAL domain
LH044_08535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LH044_08545	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH044_08550	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LH044_08555	COG2205	protein histidine kinase activity
LH044_08560	COG0745	RESPONSE REGULATOR receiver
LH044_08590	COG0477	Major facilitator Superfamily
LH044_08625	COG2217	Heavy metal translocating P-type atpase
LH044_08655	COG0492	ferredoxin-NADP+ reductase activity
LH044_08685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LH044_08690	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LH044_08700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LH044_08765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LH044_08780	COG3002	Belongs to the UPF0753 family
LH044_08785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH044_08790	COG0076	glutamate decarboxylase activity
LH044_08800	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LH044_08815	COG3795	YCII-related domain
LH044_08820	COG4941	Belongs to the sigma-70 factor family
LH044_08830	COG2175	clavaminate synthase activity
LH044_08835	COG2208	phosphoserine phosphatase activity
LH044_08840	COG0596	Alpha beta hydrolase
LH044_08855	COG3706	GGDEF domain
LH044_08900	COG1024	Enoyl-CoA hydratase
LH044_08945	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_08955	COG0500	methyltransferase
LH044_08960	COG2226	methyltransferase
LH044_08985	COG0542	response to heat
LH044_09000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LH044_09005	COG0443	Heat shock 70 kDa protein
LH044_09010	COG3903	Transcriptional regulator
LH044_09010	COG2197	response regulator
LH044_09030	COG1177	transmembrane transport
LH044_09035	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH044_09045	COG3842	ATPase activity
LH044_09055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH044_09065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH044_09075	COG0519	Catalyzes the synthesis of GMP from XMP
LH044_09135	COG0148	phosphopyruvate hydratase activity
LH044_09140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH044_09140	COG2755	lipolytic protein G-D-S-L family
LH044_09145	COG2124	cytochrome p450
LH044_09160	COG3956	TIGRFAM MazG family protein
LH044_09175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH044_09185	COG0193	aminoacyl-tRNA hydrolase activity
LH044_09190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LH044_09200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LH044_09205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH044_09215	COG1215	transferase activity, transferring glycosyl groups
LH044_09220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH044_09245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LH044_09250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LH044_09260	COG0084	hydrolase, TatD family'
LH044_09275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH044_09285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LH044_09295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH044_09300	COG1691	(AIR) carboxylase
LH044_09305	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
LH044_09310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LH044_09320	COG0012	GTP binding
LH044_09325	COG1796	DNA polymerase
LH044_09325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LH044_09335	COG0415	Belongs to the DNA photolyase family
LH044_09355	COG1960	acyl-CoA dehydrogenase activity
LH044_09365	COG1024	Enoyl-CoA hydratase
LH044_09385	COG0308	aminopeptidase N
LH044_09390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH044_09400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH044_09405	COG1473	amidohydrolase
LH044_09425	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_09490	COG0519	Catalyzes the synthesis of GMP from XMP
LH044_09490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH044_09525	COG0644	oxidoreductase
LH044_09535	COG1230	cation diffusion facilitator family transporter
LH044_09555	COG1902	pentaerythritol trinitrate reductase activity
LH044_09555	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH044_09570	COG0640	Transcriptional regulator
LH044_09585	COG4122	O-methyltransferase activity
LH044_09610	COG0714	Associated with various cellular activities
LH044_09635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH044_09640	COG1477	protein flavinylation
LH044_09655	COG2353	YceI-like domain
LH044_09675	COG3119	arylsulfatase activity
LH044_09680	COG0494	nUDIX hydrolase
LH044_09700	COG0488	(ABC) transporter
LH044_09730	COG1309	transcriptional regulator
LH044_09740	COG3795	YCII-related domain
LH044_09770	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_09790	COG2119	membrane
LH044_09795	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_09825	COG3132	Protein of unknown function, DUF480
LH044_09840	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_09850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH044_09855	COG3304	Inner membrane component domain
LH044_09860	COG0596	Alpha beta hydrolase
LH044_09880	COG0183	Belongs to the thiolase family
LH044_09905	COG0477	Major facilitator Superfamily
LH044_09925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_09940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_09960	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LH044_10020	COG0315	cyclic pyranopterin monophosphate synthase activity
LH044_10030	COG3706	GGDEF domain
LH044_10035	COG2608	mercury ion transmembrane transporter activity
LH044_10040	COG1937	Protein conserved in bacteria
LH044_10060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH044_10075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH044_10080	COG0303	'Molybdopterin
LH044_10085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH044_10105	COG2018	Roadblock/LC7 domain
LH044_10110	COG5002	protein histidine kinase activity
LH044_10130	COG2814	Major facilitator Superfamily
LH044_10135	COG0745	RESPONSE REGULATOR receiver
LH044_10140	COG5002	protein histidine kinase activity
LH044_10150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH044_10155	COG0581	inorganic phosphate transmembrane transporter activity
LH044_10160	COG0573	inorganic phosphate transmembrane transporter activity
LH044_10165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LH044_10170	COG0494	nUDIX hydrolase
LH044_10170	COG0406	alpha-ribazole phosphatase activity
LH044_10185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH044_10200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LH044_10215	COG1793	dna ligase
LH044_10215	COG3285	dna ligase
LH044_10235	COG1305	Transglutaminase-like
LH044_10245	COG2308	Evidence 4 Homologs of previously reported genes of
LH044_10255	COG2264	protein methyltransferase activity
LH044_10270	COG1053	succinate dehydrogenase
LH044_10275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LH044_10280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH044_10345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH044_10370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH044_10375	COG0039	L-malate dehydrogenase activity
LH044_10395	COG1132	(ABC) transporter
LH044_10400	COG1132	(ABC) transporter
LH044_10425	COG3842	ATPase activity
LH044_10430	COG4208	sulfate ABC transporter
LH044_10440	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LH044_10445	COG0538	isocitrate dehydrogenase activity
LH044_10450	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LH044_10460	COG0411	ABC transporter
LH044_10485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_10490	COG1305	Transglutaminase-like
LH044_10500	COG0714	Associated with various cellular activities
LH044_10560	COG1459	type II secretion system
LH044_10570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH044_10595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LH044_10630	COG0138	bifunctional purine biosynthesis protein purh
LH044_10645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LH044_10660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_10685	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_10690	COG0210	DNA helicase
LH044_10705	COG0741	lytic transglycosylase activity
LH044_10705	COG0791	NLP P60 protein
LH044_10720	COG4585	Histidine kinase
LH044_10725	COG2197	response regulator
LH044_10730	COG0519	Catalyzes the synthesis of GMP from XMP
LH044_10730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH044_10735	COG0516	GMP reductase activity
LH044_10740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH044_10745	COG0156	8-amino-7-oxononanoate synthase activity
LH044_10755	COG1252	NADH dehydrogenase
LH044_10760	COG0516	GMP reductase activity
LH044_10760	COG0517	IMP dehydrogenase activity
LH044_10765	COG0494	nUDIX hydrolase
LH044_10790	COG0459	protein refolding
LH044_10795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH044_10805	COG0477	Major facilitator Superfamily
LH044_10820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LH044_10830	COG0456	acetyltransferase
LH044_10830	COG1214	PFAM Peptidase M22, glycoprotease
LH044_10835	COG0802	atpase or kinase
LH044_10840	COG1573	uracil-dna glycosylase
LH044_10845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH044_10855	COG0736	holo-[acyl-carrier-protein] synthase activity
LH044_10860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH044_10870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH044_10875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH044_10880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LH044_10885	COG0101	tRNA pseudouridine synthase activity
LH044_10890	COG0203	ribosomal protein L17
LH044_10895	COG0202	RNA polymerase activity
LH044_10900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH044_10905	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LH044_10915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH044_10920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH044_10935	COG0200	Binds to the 23S rRNA
LH044_10940	COG1841	ribosomal large subunit assembly
LH044_10945	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LH044_10950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LH044_10955	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LH044_10960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LH044_10965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH044_10970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LH044_10975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LH044_10980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LH044_10990	COG0255	Belongs to the universal ribosomal protein uL29 family
LH044_10995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LH044_11000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LH044_11010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LH044_11015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LH044_11020	COG0089	rRNA binding
LH044_11025	COG0088	Forms part of the polypeptide exit tunnel
LH044_11030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LH044_11045	COG0051	transcription antitermination factor activity, RNA binding
LH044_11055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH044_11060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH044_11065	COG0049	tRNA binding
LH044_11070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LH044_11075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LH044_11080	COG0085	RNA polymerase activity
LH044_11085	COG0222	ribosome binding
LH044_11090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LH044_11095	COG0081	regulation of translation
LH044_11100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LH044_11105	COG0250	Participates in transcription elongation, termination and antitermination
LH044_11110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH044_11130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LH044_11135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH044_11170	COG1666	GTP binding
LH044_11175	COG0501	Belongs to the peptidase M48B family
LH044_11185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH044_11195	COG1007	ATP synthesis coupled electron transport
LH044_11205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH044_11210	COG0713	ATP synthesis coupled electron transport
LH044_11215	COG0839	Belongs to the complex I subunit 6 family
LH044_11220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH044_11225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LH044_11230	COG0649	NAD binding
LH044_11240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH044_11245	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH044_11280	COG0297	glycogen (starch) synthase activity
LH044_11290	COG0438	transferase activity, transferring glycosyl groups
LH044_11295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH044_11300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH044_11330	COG1086	Polysaccharide biosynthesis protein
LH044_11345	COG0438	transferase activity, transferring glycosyl groups
LH044_11410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH044_11440	COG3128	pkhd-type hydroxylase
LH044_11465	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LH044_11470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH044_11485	COG1007	ATP synthesis coupled electron transport
LH044_11500	COG0713	ATP synthesis coupled electron transport
LH044_11510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH044_11515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LH044_11520	COG1034	ATP synthesis coupled electron transport
LH044_11535	COG0649	NAD binding
LH044_11540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH044_11575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LH044_11600	COG0628	permease
LH044_11615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH044_11620	COG0113	porphobilinogen synthase activity
LH044_11625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH044_11640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LH044_11645	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LH044_11655	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_11665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LH044_11680	COG0438	transferase activity, transferring glycosyl groups
LH044_11735	COG1024	Enoyl-CoA hydratase
LH044_11745	COG4974	Belongs to the 'phage' integrase family
LH044_11840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_11850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LH044_11900	COG0154	amidase activity
LH044_11915	COG0750	zinc metalloprotease
LH044_11920	COG0513	Belongs to the DEAD box helicase family
LH044_11925	COG0756	dUTP diphosphatase activity
LH044_11930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LH044_11935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH044_11965	COG0259	pyridoxamine-phosphate oxidase activity
LH044_11970	COG0038	chloride channel
LH044_11975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LH044_11995	COG1595	DNA-templated transcription, initiation
LH044_12010	COG1131	(ABC) transporter
LH044_12030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH044_12035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH044_12035	COG2010	Cytochrome c
LH044_12050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH044_12055	COG0109	protoheme IX farnesyltransferase activity
LH044_12060	COG1612	heme a metabolic process
LH044_12065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LH044_12115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LH044_12135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH044_12145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH044_12155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH044_12165	COG0047	phosphoribosylformylglycinamidine synthase activity
LH044_12175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LH044_12180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH044_12190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH044_12210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LH044_12215	COG2755	lipolytic protein G-D-S-L family
LH044_12215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH044_12230	COG0542	response to heat
LH044_12240	COG0789	Transcriptional regulator
LH044_12245	COG0484	heat shock protein binding
LH044_12250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LH044_12255	COG0443	Heat shock 70 kDa protein
LH044_12260	COG1215	transferase activity, transferring glycosyl groups
LH044_12265	COG0588	phosphoglycerate mutase activity
LH044_12270	COG1192	Involved in chromosome partitioning
LH044_12275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH044_12280	COG0247	lactate metabolic process
LH044_12280	COG2181	nitrate reductase activity
LH044_12290	COG0717	Belongs to the dCTP deaminase family
LH044_12360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LH044_12360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LH044_12370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_12395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LH044_12410	COG1793	dna ligase
LH044_12415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH044_12415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH044_12425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LH044_12435	COG3118	belongs to the thioredoxin family
LH044_12435	COG0492	ferredoxin-NADP+ reductase activity
LH044_12450	COG2890	protein-(glutamine-N5) methyltransferase activity
LH044_12455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH044_12460	COG1554	hydrolase, family 65, central catalytic
LH044_12465	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LH044_12475	COG1845	cytochrome c oxidase, subunit III
LH044_12485	COG0723	plastoquinol--plastocyanin reductase activity
LH044_12500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH044_12505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH044_12525	COG0657	acetylesterase activity
LH044_12540	COG3119	arylsulfatase activity
LH044_12560	COG0426	domain, Protein
LH044_12560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH044_12585	COG0346	lactoylglutathione lyase activity
LH044_12590	COG0604	alcohol dehydrogenase
LH044_12605	COG0183	Belongs to the thiolase family
LH044_12615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LH044_12620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LH044_12650	COG0590	tRNA wobble adenosine to inosine editing
LH044_12675	COG1968	undecaprenyl-diphosphatase activity
LH044_12680	COG1132	(ABC) transporter
LH044_12695	COG1722	exodeoxyribonuclease VII activity
LH044_12715	COG2197	response regulator
LH044_12725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH044_12730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LH044_12760	COG3548	integral membrane protein
LH044_12765	COG0386	Belongs to the glutathione peroxidase family
LH044_12780	COG2409	Drug exporters of the RND superfamily
LH044_12785	COG1733	regulation of RNA biosynthetic process
LH044_12790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_12795	COG0586	Pfam SNARE associated Golgi protein
LH044_12800	COG1960	acyl-CoA dehydrogenase activity
LH044_12805	COG1733	regulation of RNA biosynthetic process
LH044_12810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH044_12815	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LH044_12845	COG0393	Putative heavy-metal-binding
LH044_12855	COG2818	Glycosylase
LH044_12860	COG2814	Major facilitator Superfamily
LH044_12875	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_12880	COG1024	Enoyl-CoA hydratase
LH044_12885	COG2205	protein histidine kinase activity
LH044_12890	COG0745	RESPONSE REGULATOR receiver
LH044_12915	COG0183	Belongs to the thiolase family
LH044_12930	COG0512	Glutamine amidotransferase of anthranilate synthase
LH044_12930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH044_12935	COG2815	serine threonine protein kinase
LH044_12935	COG0515	serine threonine protein kinase
LH044_12945	COG0515	serine threonine protein kinase
LH044_12950	COG0768	penicillin binding
LH044_12960	COG0631	protein serine/threonine phosphatase activity
LH044_12965	COG1716	ATPase activity
LH044_12975	COG2258	MOSC domain
LH044_12990	COG1024	Enoyl-CoA hydratase
LH044_13005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH044_13015	COG1116	anion transmembrane transporter activity
LH044_13050	COG4585	Histidine kinase
LH044_13055	COG2197	response regulator
LH044_13095	COG1703	isobutyryl-CoA mutase activity
LH044_13135	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH044_13150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH044_13165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH044_13170	COG0077	Prephenate dehydratase
LH044_13185	COG0438	transferase activity, transferring glycosyl groups
LH044_13210	COG2326	polyphosphate kinase activity
LH044_13215	COG1271	oxidase subunit
LH044_13220	COG1294	oxidase, subunit
LH044_13280	COG0477	Major facilitator Superfamily
LH044_13300	COG2226	methyltransferase
LH044_13330	COG1793	dna ligase
LH044_13350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH044_13365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH044_13375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_13385	COG3387	PFAM Glycoside hydrolase 15-related
LH044_13390	COG0114	fumarate hydratase activity
LH044_13400	COG1946	Acyl-CoA thioesterase
LH044_13410	COG1191	sigma factor activity
LH044_13430	COG3266	domain, Protein
LH044_13440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH044_13445	COG0187	DNA topoisomerase II activity
LH044_13455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LH044_13460	COG0592	DNA-directed DNA polymerase activity
LH044_13465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH044_13470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LH044_13475	COG0594	ribonuclease P activity
LH044_13480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LH044_13485	COG0706	membrane insertase activity
LH044_13495	COG0357	Ribosomal RNA small subunit methyltransferase G
LH044_13500	COG1192	Involved in chromosome partitioning
LH044_13515	COG3118	belongs to the thioredoxin family
LH044_13520	COG0492	ferredoxin-NADP+ reductase activity
LH044_13535	COG1595	DNA-templated transcription, initiation
LH044_13540	COG0515	serine threonine protein kinase
LH044_13540	COG2815	serine threonine protein kinase
LH044_13555	COG0123	including yeast histone deacetylase and acetoin utilization protein
LH044_13565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH044_13575	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LH044_13585	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LH044_13590	COG0360	Binds together with S18 to 16S ribosomal RNA
LH044_13605	COG0359	binds to the 23S rRNA
LH044_13630	COG1122	ATPase activity
LH044_13650	COG1960	acyl-CoA dehydrogenase activity
LH044_13660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LH044_13665	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH044_13675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LH044_13705	COG2340	Cysteine-rich secretory protein family
LH044_13715	COG0745	RESPONSE REGULATOR receiver
LH044_13755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_13770	COG0316	Belongs to the HesB IscA family
LH044_13805	COG0251	oxidation-reduction process
LH044_13815	COG0745	RESPONSE REGULATOR receiver
LH044_13820	COG0174	glutamine synthetase
LH044_13830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LH044_13830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH044_13840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH044_13880	COG1111	helicase
LH044_13880	COG1205	dead DEAH box helicase
LH044_13890	COG1960	acyl-CoA dehydrogenase activity
LH044_13895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LH044_13895	COG1754	DNA topoisomerase type I activity
LH044_13900	COG2814	Major facilitator Superfamily
LH044_13905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LH044_13925	COG1733	regulation of RNA biosynthetic process
LH044_13940	COG4941	Belongs to the sigma-70 factor family
LH044_13950	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_13960	COG1595	DNA-templated transcription, initiation
LH044_13980	COG0037	tRNA processing
LH044_13985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LH044_13995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH044_14000	COG0302	gtp cyclohydrolase
LH044_14005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LH044_14020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LH044_14030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LH044_14035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LH044_14045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LH044_14050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LH044_14070	COG0142	geranyltranstransferase activity
LH044_14090	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LH044_14095	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LH044_14115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LH044_14120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LH044_14125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH044_14140	COG1309	transcriptional regulator
LH044_14150	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_14160	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
LH044_14215	COG2045	Belongs to the ComB family
LH044_14240	COG0243	molybdopterin cofactor binding
LH044_14280	COG2318	DinB family
LH044_14285	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LH044_14310	COG0426	domain, Protein
LH044_14310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH044_14315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LH044_14355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LH044_14395	COG1116	anion transmembrane transporter activity
LH044_14410	COG2409	Drug exporters of the RND superfamily
LH044_14435	COG0270	DNA (cytosine-5-)-methyltransferase activity
LH044_14455	COG1078	dGTPase activity
LH044_14520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH044_14530	COG2070	2-Nitropropane dioxygenase
LH044_14625	COG1136	(ABC) transporter
LH044_14630	COG1136	(ABC) transporter
LH044_14630	COG0577	efflux transmembrane transporter activity
LH044_14645	COG1653	transport
LH044_14685	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LH044_14690	COG1929	Belongs to the glycerate kinase type-1 family
LH044_14695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LH044_14700	COG0463	Glycosyl transferase, family 2
LH044_14705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LH044_14730	COG0640	Transcriptional regulator
LH044_14750	COG0730	response to heat
LH044_14755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LH044_14775	COG3253	May function as heme-dependent peroxidase
LH044_14805	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LH044_14810	COG1051	belongs to the nudix hydrolase family
LH044_14835	COG1946	Acyl-CoA thioesterase
LH044_14860	COG2226	methyltransferase
LH044_14865	COG0438	transferase activity, transferring glycosyl groups
LH044_14870	COG1490	D-aminoacyl-tRNA deacylase activity
LH044_14885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LH044_14890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LH044_14895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LH044_14925	COG1321	iron dependent repressor
LH044_14935	COG1201	RNA secondary structure unwinding
LH044_14940	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_14945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH044_14955	COG3631	Ketosteroid isomerase-related protein
LH044_14970	COG0577	efflux transmembrane transporter activity
LH044_14970	COG1136	(ABC) transporter
LH044_14975	COG1216	Glycosyl transferase, family 2
LH044_14985	COG1672	PFAM Archaeal ATPase
LH044_14985	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LH044_14990	COG0450	alkyl hydroperoxide reductase
LH044_15005	COG2755	lipolytic protein G-D-S-L family
LH044_15005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH044_15010	COG0187	DNA topoisomerase II activity
LH044_15040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH044_15045	COG0154	amidase activity
LH044_15050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_15055	COG1024	Enoyl-CoA hydratase
LH044_15080	COG1960	acyl-CoA dehydrogenase activity
LH044_15085	COG1960	acyl-CoA dehydrogenase activity
LH044_15095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LH044_15150	COG1472	Belongs to the glycosyl hydrolase 3 family
LH044_15165	COG2124	cytochrome p450
LH044_15170	COG2124	cytochrome p450
LH044_15190	COG2247	cell wall binding repeat
LH044_15190	COG2385	sporulation resulting in formation of a cellular spore
LH044_15195	COG3568	Endonuclease Exonuclease Phosphatase
LH044_15210	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LH044_15210	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LH044_15225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH044_15270	COG4941	Belongs to the sigma-70 factor family
LH044_15285	COG0154	amidase activity
LH044_15320	COG0475	glutathione-regulated potassium exporter activity
LH044_15320	COG0569	domain protein
LH044_15335	COG2130	NADP-dependent
LH044_15370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH044_15380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH044_15400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH044_15405	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LH044_15435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LH044_15440	COG2890	protein-(glutamine-N5) methyltransferase activity
LH044_15450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LH044_15455	COG0243	molybdopterin cofactor binding
LH044_15470	COG1192	Involved in chromosome partitioning
LH044_15485	COG0539	negative regulation of cytoplasmic translation
LH044_15505	COG1061	Type III restriction enzyme res subunit
LH044_15510	COG1643	Atp-dependent helicase
LH044_15575	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_15585	COG1024	Enoyl-CoA hydratase
LH044_15585	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH044_15610	COG2070	2-Nitropropane dioxygenase
LH044_15620	COG5001	Diguanylate cyclase
LH044_15625	COG1960	acyl-CoA dehydrogenase activity
LH044_15630	COG1960	acyl-CoA dehydrogenase activity
LH044_15635	COG0419	ATPase involved in DNA repair
LH044_15640	COG0420	3'-5' exonuclease activity
LH044_15660	COG1322	Protein conserved in bacteria
LH044_15665	COG3228	Belongs to the MtfA family
LH044_15680	COG0598	Magnesium transport protein CorA
LH044_15700	COG2226	methyltransferase
LH044_15705	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LH044_15715	COG0644	oxidoreductase
LH044_15725	COG2815	serine threonine protein kinase
LH044_15725	COG0515	serine threonine protein kinase
LH044_15770	COG1012	belongs to the aldehyde dehydrogenase family
LH044_15775	COG2199	diguanylate cyclase activity
LH044_15775	COG3287	FIST C domain
LH044_15775	COG2200	EAL domain
LH044_15785	COG0657	acetylesterase activity
LH044_15790	COG1131	(ABC) transporter
LH044_15800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LH044_15805	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LH044_15815	COG1132	(ABC) transporter
LH044_15820	COG0674	pyruvate-flavodoxin oxidoreductase activity
LH044_15820	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LH044_15825	COG1013	pyruvate-flavodoxin oxidoreductase activity
LH044_15850	COG2193	ferroxidase activity
LH044_15875	COG0596	Alpha beta hydrolase
LH044_15900	COG0183	Belongs to the thiolase family
LH044_15920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LH044_15930	COG1960	acyl-CoA dehydrogenase activity
LH044_15955	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_15960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LH044_15965	COG0183	Belongs to the thiolase family
LH044_15985	COG1960	acyl-CoA dehydrogenase activity
LH044_16020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH044_16045	COG1388	LysM domain
LH044_16065	COG0488	(ABC) transporter
LH044_16070	COG0657	acetylesterase activity
LH044_16085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LH044_16095	COG2267	carboxylic ester hydrolase activity
LH044_16105	COG0312	modulator of DNA gyrase
LH044_16125	COG0312	modulator of DNA gyrase
LH044_16140	COG0314	molybdopterin synthase activity
LH044_16150	COG1077	Cell shape determining protein MreB Mrl
LH044_16195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LH044_16205	COG1615	UPF0182 protein
LH044_16210	COG0586	Pfam SNARE associated Golgi protein
LH044_16215	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LH044_16260	COG1024	Enoyl-CoA hydratase
LH044_16265	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LH044_16270	COG3804	dihydrodipicolinate reductase
LH044_16275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH044_16325	COG2801	Transposase and inactivated derivatives
LH044_16350	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_16355	COG1309	transcriptional regulator
LH044_16360	COG1960	acyl-CoA dehydrogenase activity
LH044_16365	COG1960	acyl-CoA dehydrogenase activity
LH044_16370	COG1024	Enoyl-CoA hydratase
LH044_16390	COG3250	beta-galactosidase activity
LH044_16405	COG0411	ABC transporter
LH044_16415	COG3250	beta-galactosidase activity
LH044_16445	COG3347	Dehydrogenase
LH044_16445	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_16450	COG1070	Carbohydrate kinase
LH044_16465	COG0426	domain, Protein
LH044_16465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH044_16470	COG3903	Transcriptional regulator
LH044_16470	COG3629	intracellular signal transduction
LH044_16485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LH044_16505	COG5002	protein histidine kinase activity
LH044_16510	COG0745	RESPONSE REGULATOR receiver
LH044_16535	COG3119	arylsulfatase activity
LH044_16540	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LH044_16570	COG0142	geranyltranstransferase activity
LH044_16620	COG2115	Belongs to the xylose isomerase family
LH044_16625	COG1070	Carbohydrate kinase
LH044_16640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH044_16665	COG2124	cytochrome p450
LH044_16675	COG2070	2-Nitropropane dioxygenase
LH044_16700	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_16705	COG1191	sigma factor activity
LH044_16720	COG1278	Cold shock
LH044_16735	COG0183	Belongs to the thiolase family
LH044_16770	COG2197	response regulator
LH044_16785	COG0477	Major facilitator Superfamily
LH044_16795	COG0673	inositol 2-dehydrogenase activity
LH044_16845	COG4221	oxidoreductase activity
LH044_16925	COG0443	Heat shock 70 kDa protein
LH044_16945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH044_16970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_17035	COG0604	alcohol dehydrogenase
LH044_17040	COG1024	Enoyl-CoA hydratase
LH044_17045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_17050	COG1960	acyl-CoA dehydrogenase activity
LH044_17055	COG1960	acyl-CoA dehydrogenase activity
LH044_17065	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_17090	COG1960	acyl-CoA dehydrogenase activity
LH044_17095	COG1960	acyl-CoA dehydrogenase activity
LH044_17100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_17110	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_17115	COG1960	acyl-CoA dehydrogenase activity
LH044_17120	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_17125	COG0300	oxidoreductase activity
LH044_17140	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_17145	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_17170	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_17175	COG1960	acyl-CoA dehydrogenase activity
LH044_17195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH044_17215	COG1063	alcohol dehydrogenase
LH044_17220	COG1070	Carbohydrate kinase
LH044_17225	COG1063	alcohol dehydrogenase
LH044_17250	COG4941	Belongs to the sigma-70 factor family
LH044_17255	COG3795	YCII-related domain
LH044_17265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LH044_17265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LH044_17265	COG1703	isobutyryl-CoA mutase activity
LH044_17295	COG0596	Alpha beta hydrolase
LH044_17300	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_17370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH044_17405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH044_17425	COG3265	gluconokinase activity
LH044_17430	COG3655	Transcriptional regulator
LH044_17455	COG0384	phenazine biosynthesis protein PhzF
LH044_17490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LH044_17500	COG0431	NADPH-dependent FMN reductase
LH044_17560	COG1174	glycine betaine transport
LH044_17565	COG1174	glycine betaine transport
LH044_17595	COG0183	Belongs to the thiolase family
LH044_17615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH044_17635	COG4221	oxidoreductase activity
LH044_17640	COG2146	nitrite reductase [NAD(P)H] activity
LH044_17640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH044_17655	COG2223	nitrite transmembrane transporter activity
LH044_17660	COG0437	4 iron, 4 sulfur cluster binding
LH044_17665	COG0243	molybdopterin cofactor binding
LH044_17670	COG0477	Major facilitator Superfamily
LH044_17685	COG2318	DinB family
LH044_17690	COG0477	Major facilitator Superfamily
LH044_17705	COG4424	Sulfotransferase
LH044_17710	COG3119	arylsulfatase activity
LH044_17715	COG1132	(ABC) transporter
LH044_17720	COG1132	(ABC) transporter
LH044_17725	COG1309	transcriptional regulator
LH044_17760	COG1597	lipid kinase activity
LH044_17760	COG1803	Methylglyoxal synthase
LH044_17790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_17805	COG1063	alcohol dehydrogenase
LH044_17835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_17840	COG0667	Aldo Keto reductase
LH044_17870	COG0693	protein deglycase activity
LH044_17875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LH044_17905	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_17925	COG1960	acyl-CoA dehydrogenase activity
LH044_17930	COG1960	acyl-CoA dehydrogenase activity
LH044_17940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_17945	COG3300	MHYT domain
LH044_17945	COG5001	Diguanylate cyclase
LH044_17955	COG0640	Transcriptional regulator
LH044_17995	COG2175	clavaminate synthase activity
LH044_18005	COG1116	anion transmembrane transporter activity
LH044_18010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH044_18015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH044_18020	COG3540	Alkaline phosphatase
LH044_18055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH044_18095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH044_18120	COG1131	(ABC) transporter
LH044_18125	COG3795	YCII-related domain
LH044_18130	COG4941	Belongs to the sigma-70 factor family
LH044_18140	COG2175	clavaminate synthase activity
LH044_18150	COG2124	cytochrome p450
LH044_18165	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LH044_18170	COG2375	cellular response to nickel ion
LH044_18190	COG1960	acyl-CoA dehydrogenase activity
LH044_18195	COG0183	Belongs to the thiolase family
LH044_18205	COG2066	Belongs to the glutaminase family
LH044_18205	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LH044_18215	COG2175	clavaminate synthase activity
LH044_18225	COG1320	monovalent cation:proton antiporter activity
LH044_18230	COG2212	antiporter activity
LH044_18240	COG0651	ATP synthesis coupled electron transport
LH044_18245	COG1006	Multisubunit Na H antiporter MnhC subunit
LH044_18250	COG2111	Na H antiporter
LH044_18255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH044_18255	COG2111	Na H antiporter
LH044_18270	COG2132	Multicopper oxidase
LH044_18325	COG1116	anion transmembrane transporter activity
LH044_18330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH044_18365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LH044_18380	COG0583	DNA-binding transcription factor activity
LH044_18385	COG3634	alkyl hydroperoxide reductase activity
LH044_18400	COG1191	sigma factor activity
LH044_18415	COG3237	CsbD-like
LH044_18420	COG0372	Belongs to the citrate synthase family
LH044_18430	COG0640	Transcriptional regulator
LH044_18440	COG0740	serine-type endopeptidase activity
LH044_18445	COG0672	)-iron permease
LH044_18455	COG2837	iron assimilation
LH044_18460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH044_18475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH044_18495	COG3706	GGDEF domain
LH044_18515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LH044_18525	COG0277	FAD linked oxidase domain protein
LH044_18535	COG1388	LysM domain
LH044_18535	COG3942	CHAP domain
LH044_18540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_18545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_18550	COG0363	glucosamine-6-phosphate deaminase activity
LH044_18555	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LH044_18560	COG0166	Belongs to the GPI family
LH044_18590	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_18595	COG0577	efflux transmembrane transporter activity
LH044_18595	COG1136	(ABC) transporter
LH044_18600	COG2272	Belongs to the type-B carboxylesterase lipase family
LH044_18630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH044_18650	COG0657	acetylesterase activity
LH044_18655	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH044_18670	COG0183	Belongs to the thiolase family
LH044_18730	COG1024	Enoyl-CoA hydratase
LH044_18735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH044_18740	COG1278	Cold shock
LH044_18790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LH044_18810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LH044_18820	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_18825	COG2124	cytochrome p450
LH044_18850	COG1595	DNA-templated transcription, initiation
LH044_18930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH044_18950	COG0154	amidase activity
LH044_18965	COG0424	maF-like protein
LH044_18980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH044_18990	COG0517	IMP dehydrogenase activity
LH044_19000	COG1472	Belongs to the glycosyl hydrolase 3 family
LH044_19010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LH044_19040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH044_19055	COG1024	Enoyl-CoA hydratase
LH044_19075	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LH044_19085	COG1704	LemA family
LH044_19090	COG1309	transcriptional regulator
LH044_19095	COG2409	Drug exporters of the RND superfamily
LH044_19110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH044_19140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LH044_19155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH044_19160	COG2301	Belongs to the HpcH HpaI aldolase family
LH044_19175	COG1012	belongs to the aldehyde dehydrogenase family
LH044_19200	COG2030	dehydratase
LH044_19205	COG2226	methyltransferase
LH044_19210	COG1194	a g-specific adenine glycosylase
LH044_19215	COG1234	tRNA 3'-trailer cleavage
LH044_19240	COG0719	Fe-S assembly protein
LH044_19255	COG0719	Fe-S assembly protein
LH044_19260	COG2146	nitrite reductase [NAD(P)H] activity
LH044_19265	COG0396	ATPase activity
LH044_19280	COG2154	pterin-4-alpha-carbinolamine dehydratase
LH044_19295	COG0402	S-adenosylhomocysteine deaminase activity
LH044_19335	COG3964	amidohydrolase
LH044_19360	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LH044_19365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH044_19400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LH044_19405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LH044_19420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH044_19440	COG0822	iron-sulfur transferase activity
LH044_19445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LH044_19450	COG0396	ATPase activity
LH044_19465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH044_19470	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
LH044_19525	COG3420	alginic acid biosynthetic process
LH044_19535	COG1960	acyl-CoA dehydrogenase activity
LH044_19565	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LH044_19610	COG1910	domain protein
LH044_19670	COG1090	epimerase
LH044_19680	COG2205	protein histidine kinase activity
LH044_19685	COG0745	RESPONSE REGULATOR receiver
LH044_19690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH044_19695	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH044_19700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LH044_19710	COG1960	acyl-CoA dehydrogenase activity
LH044_19750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH044_19755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH044_19765	COG1410	methionine synthase
LH044_19765	COG0646	methionine synthase
LH044_19775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH044_19795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LH044_19805	COG0579	oxidoreductase
LH044_19830	COG0438	transferase activity, transferring glycosyl groups
LH044_19830	COG1216	Glycosyl transferase, family 2
LH044_19850	COG0438	transferase activity, transferring glycosyl groups
LH044_19890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH044_19910	COG2226	methyltransferase
LH044_19930	COG4770	biotin carboxylase activity
LH044_19945	COG0512	Glutamine amidotransferase of anthranilate synthase
LH044_19945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LH044_19950	COG1316	TRANSCRIPTIONal
LH044_19955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH044_19960	COG0438	transferase activity, transferring glycosyl groups
LH044_19980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LH044_19985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH044_19990	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_19995	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LH044_19995	COG0778	Nitroreductase
LH044_20000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LH044_20020	COG0596	Alpha beta hydrolase
LH044_20055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH044_20080	COG1215	transferase activity, transferring glycosyl groups
LH044_20085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH044_20090	COG2835	tetraacyldisaccharide 4'-kinase activity
LH044_20105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LH044_20135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LH044_20140	COG2884	Cell division ATP-binding protein ftsE
LH044_20145	COG2177	Part of the ABC transporter FtsEX involved in
LH044_20150	COG1024	Enoyl-CoA hydratase
LH044_20160	COG1309	transcriptional regulator
LH044_20165	COG0477	Major facilitator Superfamily
LH044_20170	COG3285	dna ligase
LH044_20170	COG1793	dna ligase
LH044_20205	COG3537	Alpha-1,2-mannosidase
LH044_20215	COG1309	transcriptional regulator
LH044_20235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LH044_20250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LH044_20260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LH044_20265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LH044_20275	COG0788	formyltetrahydrofolate deformylase activity
LH044_20305	COG0740	serine-type endopeptidase activity
LH044_20320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH044_20325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH044_20365	COG0477	Major facilitator Superfamily
LH044_20375	COG3022	response to hydroperoxide
LH044_20385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH044_20410	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LH044_20415	COG1136	(ABC) transporter
LH044_20420	COG4585	Histidine kinase
LH044_20425	COG2197	response regulator
LH044_20430	COG2197	response regulator
LH044_20435	COG0561	phosphatase activity
LH044_20545	COG1366	Belongs to the anti-sigma-factor antagonist family
LH044_20565	COG0427	acetyl-CoA hydrolase
LH044_20585	COG0544	peptidyl-prolyl cis-trans isomerase activity
LH044_20590	COG0740	serine-type endopeptidase activity
LH044_20595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LH044_20600	COG0285	dihydrofolate synthase activity
LH044_20605	COG0105	UTP biosynthetic process
LH044_20610	COG1077	Cell shape determining protein MreB Mrl
LH044_20625	COG0768	penicillin binding
LH044_20630	COG0772	Belongs to the SEDS family
LH044_20645	COG1530	ribonuclease E activity
LH044_20650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH044_20655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LH044_20665	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LH044_20670	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_20675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LH044_20680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LH044_20685	COG1842	Phage shock protein A
LH044_20725	COG0464	growth
LH044_20730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LH044_20750	COG0488	(ABC) transporter
LH044_20780	COG0175	sulfate reduction
LH044_20805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LH044_20810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH044_20815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LH044_20825	COG0799	negative regulation of ribosome biogenesis
LH044_20840	COG0495	leucyl-tRNA aminoacylation
LH044_20845	COG0318	PFAM AMP-dependent synthetase and ligase
LH044_20850	COG0384	phenazine biosynthesis protein PhzF
LH044_20895	COG1555	photosystem II stabilization
LH044_20900	COG0658	competence protein
LH044_20900	COG2333	competence protein COMEC
LH044_20915	COG0268	Binds directly to 16S ribosomal RNA
LH044_20920	COG0481	GTPase activity
LH044_20930	COG0484	heat shock protein binding
LH044_20935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LH044_20975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH044_20980	COG1376	ErfK ybiS ycfS ynhG family protein
LH044_20985	COG5002	protein histidine kinase activity
LH044_20985	COG3447	MASE1 domain protein
LH044_20985	COG5001	Diguanylate cyclase
LH044_21070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LH044_21075	COG4535	Mg2 and Co2 transporter CorC
LH044_21085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LH044_21090	COG1381	Involved in DNA repair and RecF pathway recombination
LH044_21135	COG0671	phosphoesterase, PA-phosphatase related
LH044_21140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH044_21165	COG0243	molybdopterin cofactor binding
LH044_21170	COG1794	racemase activity, acting on amino acids and derivatives
LH044_21190	COG0483	inositol monophosphate 1-phosphatase activity
LH044_21200	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_21250	COG1063	alcohol dehydrogenase
LH044_21260	COG2267	carboxylic ester hydrolase activity
LH044_21345	COG0154	amidase activity
LH044_21425	COG0673	inositol 2-dehydrogenase activity
LH044_21450	COG1028	Short-chain dehydrogenase reductase Sdr
LH044_21495	COG1309	transcriptional regulator
LH044_21500	COG0477	Major facilitator Superfamily
LH044_21520	COG1309	transcriptional regulator
LH044_21555	COG3706	GGDEF domain
LH044_21565	COG3384	dioxygenase
LH044_21570	COG0076	glutamate decarboxylase activity
LH044_21585	COG1136	(ABC) transporter
LH044_21585	COG0577	efflux transmembrane transporter activity
LH044_21595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH044_21615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH044_21625	COG0673	inositol 2-dehydrogenase activity
LH044_21630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH044_21635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH044_21650	COG0406	alpha-ribazole phosphatase activity
LH044_21680	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH044_21700	COG5398	heme oxygenase
LH044_21720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LH044_21725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH044_21745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH044_21760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LH044_21770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)