locus-tag	class	description
HRU87_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRU87_00010	COG0592	DNA-directed DNA polymerase activity
HRU87_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRU87_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HRU87_00025	COG0187	DNA topoisomerase II activity
HRU87_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRU87_00095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRU87_00105	COG0697	spore germination
HRU87_00130	COG1960	acyl-CoA dehydrogenase activity
HRU87_00135	COG0183	Belongs to the thiolase family
HRU87_00155	COG0717	Belongs to the dCTP deaminase family
HRU87_00180	COG0443	Heat shock 70 kDa protein
HRU87_00185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRU87_00190	COG0484	heat shock protein binding
HRU87_00195	COG0789	Transcriptional regulator
HRU87_00200	COG0542	response to heat
HRU87_00245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRU87_00260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRU87_00270	COG0386	Belongs to the glutathione peroxidase family
HRU87_00280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRU87_00285	COG1064	alcohol dehydrogenase
HRU87_00300	COG0656	L-ascorbic acid biosynthetic process
HRU87_00320	COG0823	Involved in the tonB-independent uptake of proteins
HRU87_00320	COG1506	peptidase
HRU87_00320	COG4946	Tricorn protease homolog
HRU87_00375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRU87_00380	COG0047	phosphoribosylformylglycinamidine synthase activity
HRU87_00385	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRU87_00415	COG0509	glycine decarboxylation via glycine cleavage system
HRU87_00420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRU87_00425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRU87_00430	COG0151	Belongs to the GarS family
HRU87_00435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRU87_00450	COG1175	transmembrane transport
HRU87_00455	COG0395	ABC-type sugar transport system, permease component
HRU87_00460	COG2124	cytochrome p450
HRU87_00475	COG2313	pseudouridylate synthase activity
HRU87_00480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRU87_00490	COG1028	Short-chain dehydrogenase reductase Sdr
HRU87_00535	COG0640	Transcriptional regulator
HRU87_00545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRU87_00550	COG0438	transferase activity, transferring glycosyl groups
HRU87_00565	COG0745	RESPONSE REGULATOR receiver
HRU87_00595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRU87_00625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HRU87_00640	COG2197	response regulator
HRU87_00650	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRU87_00655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRU87_00660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRU87_00670	COG0590	tRNA wobble adenosine to inosine editing
HRU87_00680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HRU87_00685	COG2884	Cell division ATP-binding protein ftsE
HRU87_00695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRU87_00700	COG0085	RNA polymerase activity
HRU87_00705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRU87_00715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRU87_00720	COG0049	tRNA binding
HRU87_00725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRU87_00730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRU87_00735	COG0051	transcription antitermination factor activity, RNA binding
HRU87_00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRU87_00745	COG0088	Forms part of the polypeptide exit tunnel
HRU87_00750	COG0089	rRNA binding
HRU87_00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRU87_00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRU87_00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRU87_00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRU87_00775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRU87_00780	COG0255	Belongs to the universal ribosomal protein uL29 family
HRU87_00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRU87_00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRU87_00795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRU87_00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRU87_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRU87_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRU87_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRU87_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRU87_00825	COG1841	ribosomal large subunit assembly
HRU87_00830	COG0200	Binds to the 23S rRNA
HRU87_00840	COG0563	adenylate kinase activity
HRU87_00845	COG0024	Methionine aminopeptidase
HRU87_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRU87_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRU87_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRU87_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRU87_00870	COG0202	RNA polymerase activity
HRU87_00875	COG0203	ribosomal protein L17
HRU87_00880	COG0101	tRNA pseudouridine synthase activity
HRU87_00885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRU87_00890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRU87_00895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRU87_00905	COG1072	(Pantothenic acid kinase))
HRU87_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRU87_00915	COG0736	holo-[acyl-carrier-protein] synthase activity
HRU87_00920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRU87_00925	COG0802	atpase or kinase
HRU87_00930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRU87_00935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRU87_00950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRU87_01010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRU87_01020	COG0519	Catalyzes the synthesis of GMP from XMP
HRU87_01020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRU87_01035	COG0045	succinate-CoA ligase (ADP-forming) activity
HRU87_01055	COG0138	bifunctional purine biosynthesis protein purh
HRU87_01070	COG1132	(ABC) transporter
HRU87_01095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRU87_01100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRU87_01110	COG3844	kynureninase activity
HRU87_01115	COG1132	(ABC) transporter
HRU87_01125	COG1131	(ABC) transporter
HRU87_01145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRU87_01150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRU87_01150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRU87_01165	COG0180	Tryptophanyl-tRNA synthetase
HRU87_01180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRU87_01185	COG1053	succinate dehydrogenase
HRU87_01195	COG2009	succinate dehydrogenase
HRU87_01205	COG1744	ABC transporter substrate-binding protein PnrA-like
HRU87_01210	COG3845	ABC transporter
HRU87_01215	COG4603	Belongs to the binding-protein-dependent transport system permease family
HRU87_01220	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRU87_01235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRU87_01240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRU87_01255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRU87_01270	COG4770	biotin carboxylase activity
HRU87_01275	COG0424	maF-like protein
HRU87_01280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRU87_01305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRU87_01330	COG1388	LysM domain
HRU87_01330	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRU87_01335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRU87_01365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRU87_01370	COG0745	RESPONSE REGULATOR receiver
HRU87_01375	COG5002	protein histidine kinase activity
HRU87_01380	COG5401	PFAM Sporulation and spore germination
HRU87_01390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRU87_01395	COG0653	protein targeting
HRU87_01430	COG3845	ABC transporter
HRU87_01440	COG0646	methionine synthase
HRU87_01440	COG1410	methionine synthase
HRU87_01455	COG0765	amino acid transport
HRU87_01470	COG0586	Pfam SNARE associated Golgi protein
HRU87_01505	COG1120	ATPase activity
HRU87_01510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRU87_01515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRU87_01530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRU87_01535	COG0745	RESPONSE REGULATOR receiver
HRU87_01545	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HRU87_01560	COG0588	phosphoglycerate mutase activity
HRU87_01570	COG5002	protein histidine kinase activity
HRU87_01575	COG0745	RESPONSE REGULATOR receiver
HRU87_01585	COG1329	Transcriptional regulator
HRU87_01590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRU87_01590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRU87_01595	COG0215	cysteine-tRNA ligase activity
HRU87_01600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRU87_01610	COG3842	ATPase activity
HRU87_01640	COG1027	Aspartate ammonia-lyase
HRU87_01660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRU87_01670	COG0459	protein refolding
HRU87_01675	COG2205	protein histidine kinase activity
HRU87_01680	COG0745	RESPONSE REGULATOR receiver
HRU87_01700	COG1278	Cold shock
HRU87_01710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRU87_01755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRU87_01775	COG1090	epimerase
HRU87_01790	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
HRU87_01800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRU87_01805	COG0084	hydrolase, TatD family'
HRU87_01810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRU87_01815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRU87_01820	COG0488	(ABC) transporter
HRU87_01830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRU87_01835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRU87_01845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRU87_01850	COG0193	aminoacyl-tRNA hydrolase activity
HRU87_01875	COG0124	histidyl-tRNA synthetase
HRU87_01880	COG0148	phosphopyruvate hydratase activity
HRU87_01910	COG1704	LemA family
HRU87_01915	COG0501	Belongs to the peptidase M48B family
HRU87_01920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRU87_01925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRU87_01945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRU87_01950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HRU87_01960	COG0114	fumarate hydratase activity
HRU87_01975	COG1722	exodeoxyribonuclease VII activity
HRU87_01980	COG1570	exodeoxyribonuclease VII activity
HRU87_01985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRU87_01995	COG0191	fructose-bisphosphate aldolase activity
HRU87_02000	COG1105	Belongs to the carbohydrate kinase PfkB family
HRU87_02005	COG1322	Protein conserved in bacteria
HRU87_02015	COG0012	GTP binding
HRU87_02040	COG1045	serine acetyltransferase
HRU87_02055	COG1494	fructose-1,6-bisphosphatase
HRU87_02060	COG2807	transmembrane transport
HRU87_02065	COG0483	inositol monophosphate 1-phosphatase activity
HRU87_02070	COG1162	GTPase activity
HRU87_02075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRU87_02080	COG1595	DNA-templated transcription, initiation
HRU87_02095	COG0567	Dehydrogenase, E1 component
HRU87_02095	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRU87_02110	COG4988	ABC transporter
HRU87_02115	COG1902	pentaerythritol trinitrate reductase activity
HRU87_02125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRU87_02135	COG1473	amidohydrolase
HRU87_02140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRU87_02150	COG1349	DNA-binding transcription factor activity
HRU87_02215	COG0697	spore germination
HRU87_02230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRU87_02245	COG2089	acid synthase
HRU87_02260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRU87_02265	COG1086	Polysaccharide biosynthesis protein
HRU87_02270	COG1083	cytidylyl-transferase
HRU87_02295	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRU87_02300	COG1088	dTDP-glucose 4,6-dehydratase activity
HRU87_02315	COG1217	gtp-binding protein TYPA
HRU87_02355	COG0742	ribosomal rna small subunit methyltransferase
HRU87_02365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRU87_02375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRU87_02380	COG0571	ribonuclease III activity
HRU87_02385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRU87_02405	COG0228	four-way junction DNA binding
HRU87_02410	COG1837	Belongs to the UPF0109 family
HRU87_02415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRU87_02420	COG0336	Belongs to the RNA methyltransferase TrmD family
HRU87_02425	COG0335	large ribosomal subunit rRNA binding
HRU87_02435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRU87_02460	COG0052	Belongs to the universal ribosomal protein uS2 family
HRU87_02465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRU87_02470	COG0528	UMP kinase activity
HRU87_02475	COG0233	cytoplasmic translational termination
HRU87_02480	COG0575	Belongs to the CDS family
HRU87_02505	COG0628	permease
HRU87_02525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRU87_02530	COG0366	Alpha amylase catalytic
HRU87_02545	COG0482	sulfurtransferase activity
HRU87_02550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRU87_02555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRU87_02560	COG0154	amidase activity
HRU87_02565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRU87_02575	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRU87_02580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRU87_02585	COG1012	belongs to the aldehyde dehydrogenase family
HRU87_02595	COG2197	response regulator
HRU87_02625	COG0513	Belongs to the DEAD box helicase family
HRU87_02645	COG0813	purine-nucleoside phosphorylase activity
HRU87_02670	COG3639	organic phosphonate transmembrane transporter activity
HRU87_02675	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HRU87_02680	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRU87_02685	COG0137	argininosuccinate synthase activity
HRU87_02695	COG1982	Orn Lys Arg decarboxylase major
HRU87_02700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRU87_02710	COG1116	anion transmembrane transporter activity
HRU87_02720	COG2957	Belongs to the agmatine deiminase family
HRU87_02725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRU87_02730	COG0076	glutamate decarboxylase activity
HRU87_02740	COG0686	Belongs to the AlaDH PNT family
HRU87_02750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRU87_02760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRU87_02765	COG0629	single-stranded DNA binding
HRU87_02775	COG1946	Acyl-CoA thioesterase
HRU87_02790	COG0668	transmembrane transport
HRU87_02800	COG0475	glutathione-regulated potassium exporter activity
HRU87_02830	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRU87_02835	COG0740	serine-type endopeptidase activity
HRU87_02840	COG0740	serine-type endopeptidase activity
HRU87_02845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRU87_02850	COG3135	benzoate transporter
HRU87_02860	COG0525	valine-tRNA ligase activity
HRU87_02865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRU87_02870	COG0285	dihydrofolate synthase activity
HRU87_02890	COG1530	ribonuclease E activity
HRU87_02895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRU87_02900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRU87_02905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRU87_02910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRU87_02915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRU87_02925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRU87_02935	COG0799	negative regulation of ribosome biogenesis
HRU87_02945	COG1872	DUF167
HRU87_02950	COG0346	lactoylglutathione lyase activity
HRU87_02955	COG0400	carboxylic ester hydrolase activity
HRU87_02965	COG0587	DNA-directed DNA polymerase activity
HRU87_02975	COG2135	peptidase activity
HRU87_02990	COG0495	leucyl-tRNA aminoacylation
HRU87_03000	COG1234	tRNA 3'-trailer cleavage
HRU87_03010	COG0268	Binds directly to 16S ribosomal RNA
HRU87_03015	COG0481	GTPase activity
HRU87_03025	COG1420	regulation of RNA biosynthetic process
HRU87_03030	COG0484	heat shock protein binding
HRU87_03035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRU87_03050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRU87_03060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRU87_03065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRU87_03070	COG1381	Involved in DNA repair and RecF pathway recombination
HRU87_03075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRU87_03080	COG0423	glycine-tRNA ligase activity
HRU87_03095	COG0358	DNA primase activity
HRU87_03115	COG0242	peptide deformylase activity
HRU87_03125	COG0438	transferase activity, transferring glycosyl groups
HRU87_03135	COG1435	thymidine kinase activity
HRU87_03150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRU87_03155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRU87_03190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRU87_03225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRU87_03230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRU87_03230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRU87_03240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRU87_03245	COG0174	glutamine synthetase
HRU87_03255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRU87_03260	COG0321	lipoyl(octanoyl) transferase activity
HRU87_03265	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRU87_03270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRU87_03275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRU87_03285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRU87_03290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRU87_03305	COG0187	DNA topoisomerase II activity
HRU87_03310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRU87_03335	COG0756	dUTP diphosphatase activity
HRU87_03350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRU87_03355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRU87_03360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRU87_03390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRU87_03420	COG0737	Belongs to the 5'-nucleotidase family
HRU87_03420	COG1525	nuclease
HRU87_03420	COG4085	toxin activity
HRU87_03425	COG0579	oxidoreductase
HRU87_03435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRU87_03450	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HRU87_03455	COG0217	transcriptional regulatory protein
HRU87_03460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRU87_03465	COG0632	four-way junction helicase activity
HRU87_03470	COG2255	four-way junction helicase activity
HRU87_03475	COG1862	Preprotein translocase
HRU87_03480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRU87_03485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRU87_03490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRU87_03510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRU87_03525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRU87_03530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRU87_03545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRU87_03550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRU87_03550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRU87_03555	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRU87_03560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRU87_03565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRU87_03570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRU87_03575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRU87_03580	COG0540	Belongs to the ATCase OTCase family
HRU87_03585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRU87_03600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRU87_03605	COG0284	orotidine-5'-phosphate decarboxylase activity
HRU87_03610	COG0194	GDP metabolic process
HRU87_03615	COG1758	RNA polymerase activity
HRU87_03625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRU87_03635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRU87_03650	COG0140	phosphoribosyl-ATP diphosphatase activity
HRU87_03655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRU87_03660	COG0107	imidazoleglycerol-phosphate synthase activity
HRU87_03665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRU87_03685	COG0134	indole-3-glycerol-phosphate synthase activity
HRU87_03690	COG0133	tryptophan synthase activity
HRU87_03695	COG0159	tryptophan synthase activity
HRU87_03700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRU87_03705	COG0070	glutamate synthase
HRU87_03705	COG0067	glutamate synthase
HRU87_03705	COG0069	glutamate synthase activity
HRU87_03715	COG0469	pyruvate kinase activity
HRU87_03730	COG2050	protein possibly involved in aromatic compounds catabolism
HRU87_03740	COG0539	negative regulation of cytoplasmic translation
HRU87_03745	COG0237	dephospho-CoA kinase activity
HRU87_03750	COG0556	nucleotide-excision repair
HRU87_03765	COG1660	Displays ATPase and GTPase activities
HRU87_03770	COG1481	regulation of sporulation
HRU87_03785	COG0126	phosphoglycerate kinase activity
HRU87_03790	COG0149	triose-phosphate isomerase activity
HRU87_03795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRU87_03825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRU87_03835	COG0109	protoheme IX farnesyltransferase activity
HRU87_03840	COG0415	Belongs to the DNA photolyase family
HRU87_03855	COG0719	Fe-S assembly protein
HRU87_03865	COG0396	ATPase activity
HRU87_03870	COG2151	metal-sulfur cluster biosynthetic enzyme
HRU87_03875	COG1268	BioY protein
HRU87_03900	COG3830	Belongs to the UPF0237 family
HRU87_03900	COG0560	Phosphoserine phosphatase
HRU87_03905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRU87_03910	COG0297	glycogen (starch) synthase activity
HRU87_03915	COG1119	ATPase activity
HRU87_03920	COG0254	rRNA binding
HRU87_03925	COG2176	DNA-directed DNA polymerase activity
HRU87_03925	COG5002	protein histidine kinase activity
HRU87_03940	COG0406	alpha-ribazole phosphatase activity
HRU87_03960	COG1968	undecaprenyl-diphosphatase activity
HRU87_03970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRU87_03985	COG2378	regulation of single-species biofilm formation
HRU87_04000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRU87_04005	COG0805	protein transport
HRU87_04010	COG4581	dead DEAH box helicase
HRU87_04020	COG1216	Glycosyl transferase, family 2
HRU87_04035	COG2364	Membrane
HRU87_04045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRU87_04050	COG1845	cytochrome c oxidase, subunit III
HRU87_04055	COG2010	Cytochrome c
HRU87_04060	COG0723	plastoquinol--plastocyanin reductase activity
HRU87_04065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRU87_04075	COG1335	isochorismatase
HRU87_04085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRU87_04090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRU87_04100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRU87_04110	COG0667	Aldo Keto reductase
HRU87_04115	COG0167	dihydroorotate dehydrogenase activity
HRU87_04120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRU87_04125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRU87_04135	COG0587	DNA-directed DNA polymerase activity
HRU87_04145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRU87_04150	COG3599	regulation of cell shape
HRU87_04160	COG1799	cell septum assembly
HRU87_04165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRU87_04170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRU87_04180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRU87_04185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRU87_04190	COG0772	Belongs to the SEDS family
HRU87_04195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRU87_04200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRU87_04210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRU87_04215	COG0768	penicillin binding
HRU87_04225	COG0275	rRNA processing
HRU87_04230	COG2001	Belongs to the MraZ family
HRU87_04240	COG0142	geranyltranstransferase activity
HRU87_04250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HRU87_04260	COG1940	carbohydrate kinase activity
HRU87_04285	COG1192	Involved in chromosome partitioning
HRU87_04300	COG1716	ATPase activity
HRU87_04310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HRU87_04320	COG0039	L-malate dehydrogenase activity
HRU87_04325	COG1160	GTP binding
HRU87_04330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRU87_04350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRU87_04370	COG0504	CTP synthase activity
HRU87_04375	COG0497	DNA recombination
HRU87_04380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRU87_04390	COG0647	UMP catabolic process
HRU87_04410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRU87_04415	COG0165	Argininosuccinate lyase
HRU87_04420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRU87_04425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRU87_04430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRU87_04435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRU87_04440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRU87_04440	COG0072	phenylalanine-tRNA ligase activity
HRU87_04445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRU87_04450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRU87_04455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRU87_04460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRU87_04465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRU87_04480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRU87_04485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRU87_04490	COG0131	Imidazoleglycerol-phosphate dehydratase
HRU87_04495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRU87_04505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRU87_04510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRU87_04515	COG2813	Specifically methylates the guanine in position
HRU87_04520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRU87_04525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRU87_04530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRU87_04535	COG2137	regulation of response to DNA damage stimulus
HRU87_04540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRU87_04555	COG1546	Belongs to the CinA family
HRU87_04555	COG1058	Belongs to the CinA family
HRU87_04565	COG1674	ftsk spoiiie
HRU87_04570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HRU87_04575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRU87_04580	COG0659	secondary active sulfate transmembrane transporter activity
HRU87_04585	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HRU87_04605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRU87_04610	COG0612	Peptidase, M16
HRU87_04615	COG1185	polyribonucleotide nucleotidyltransferase activity
HRU87_04620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRU87_04625	COG3152	Membrane
HRU87_04630	COG0196	riboflavin kinase activity
HRU87_04650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRU87_04675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRU87_04680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRU87_04680	COG3266	domain, Protein
HRU87_04695	COG0442	prolyl-tRNA aminoacylation
HRU87_04700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRU87_04705	COG0750	zinc metalloprotease
HRU87_04710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRU87_04720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRU87_04725	COG1177	transmembrane transport
HRU87_04730	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRU87_04735	COG3842	ATPase activity
HRU87_04745	COG1012	belongs to the aldehyde dehydrogenase family
HRU87_04755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HRU87_04765	COG2818	Glycosylase
HRU87_04780	COG3022	response to hydroperoxide
HRU87_04785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRU87_04790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRU87_04795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRU87_04800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRU87_04805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRU87_04810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRU87_04815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRU87_04820	COG0356	it plays a direct role in the translocation of protons across the membrane
HRU87_04830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRU87_04840	COG2890	protein-(glutamine-N5) methyltransferase activity
HRU87_04845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRU87_04855	COG0083	homoserine kinase activity
HRU87_04865	COG0460	homoserine dehydrogenase
HRU87_04875	COG0018	arginyl-trna synthetase
HRU87_04880	COG0366	Alpha amylase catalytic
HRU87_04890	COG0395	ABC-type sugar transport system, permease component
HRU87_04895	COG1175	transmembrane transport
HRU87_04900	COG1653	transport
HRU87_04905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRU87_04910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRU87_04915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRU87_04930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRU87_04950	COG1615	UPF0182 protein
HRU87_05005	COG0513	Belongs to the DEAD box helicase family
HRU87_05010	COG0613	PHP domain protein
HRU87_05015	COG0006	proline dipeptidase activity
HRU87_05025	COG2239	Acts as a magnesium transporter
HRU87_05040	COG1012	belongs to the aldehyde dehydrogenase family
HRU87_05045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRU87_05060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRU87_05070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRU87_05080	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRU87_05085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRU87_05095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRU87_05100	COG0066	3-isopropylmalate dehydratase activity
HRU87_05105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRU87_05110	COG2814	Major facilitator Superfamily
HRU87_05140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRU87_05145	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRU87_05150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRU87_05155	COG0473	3-isopropylmalate dehydrogenase activity
HRU87_05170	COG1937	Protein conserved in bacteria
HRU87_05175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRU87_05185	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRU87_05200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRU87_05205	COG0440	acetolactate synthase activity
HRU87_05215	COG0129	dihydroxy-acid dehydratase activity
HRU87_05225	COG1233	COG1233 Phytoene dehydrogenase and related
HRU87_05255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRU87_05260	COG2514	catechol 2,3-dioxygenase activity
HRU87_05290	COG1280	lysine exporter protein (LysE YggA)
HRU87_05365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRU87_05370	COG1335	isochorismatase
HRU87_05395	COG0569	domain protein
HRU87_05400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRU87_05450	COG1760	l-serine dehydratase
HRU87_05455	COG0531	amino acid
HRU87_05465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HRU87_05470	COG1012	belongs to the aldehyde dehydrogenase family
HRU87_05475	COG1028	Short-chain dehydrogenase reductase Sdr
HRU87_05480	COG2186	Transcriptional regulator
HRU87_05485	COG0519	Catalyzes the synthesis of GMP from XMP
HRU87_05485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRU87_05510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRU87_05525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRU87_05530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRU87_05535	COG1754	DNA topoisomerase type I activity
HRU87_05535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRU87_05565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRU87_05570	COG0251	oxidation-reduction process
HRU87_05580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRU87_05590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRU87_05595	COG0527	aspartate kinase activity
HRU87_05600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRU87_05625	COG1012	belongs to the aldehyde dehydrogenase family
HRU87_05675	COG2197	response regulator
HRU87_05680	COG4585	Histidine kinase
HRU87_05685	COG2409	Drug exporters of the RND superfamily
HRU87_05740	COG2409	Drug exporters of the RND superfamily
HRU87_05775	COG0667	Aldo Keto reductase
HRU87_05800	COG0673	inositol 2-dehydrogenase activity
HRU87_05805	COG1082	Xylose isomerase domain protein TIM barrel
HRU87_05810	COG1082	Xylose isomerase domain protein TIM barrel
HRU87_05815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRU87_05830	COG3718	enzyme involved in inositol metabolism
HRU87_05835	COG3962	Belongs to the TPP enzyme family
HRU87_05840	COG1082	Xylose isomerase domain protein TIM barrel
HRU87_05845	COG1942	4-Oxalocrotonate Tautomerase
HRU87_05850	COG2188	Transcriptional regulator
HRU87_05860	COG1070	Carbohydrate kinase
HRU87_05865	COG2115	Belongs to the xylose isomerase family
HRU87_05870	COG1501	Belongs to the glycosyl hydrolase 31 family
HRU87_05875	COG4214	carbohydrate transport
HRU87_05900	COG2723	6-phospho-beta-galactosidase activity
HRU87_05920	COG0488	(ABC) transporter
HRU87_05930	COG1643	Atp-dependent helicase
HRU87_05945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRU87_05955	COG3046	protein related to deoxyribodipyrimidine photolyase
HRU87_05960	COG0702	epimerase
HRU87_05975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRU87_05980	COG0697	spore germination
HRU87_05985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRU87_05990	COG3253	May function as heme-dependent peroxidase
HRU87_06000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRU87_06005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRU87_06010	COG0181	hydroxymethylbilane synthase activity
HRU87_06025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRU87_06035	COG2814	Major facilitator Superfamily
HRU87_06040	COG2837	iron assimilation
HRU87_06055	COG1780	Probably involved in ribonucleotide reductase function
HRU87_06060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRU87_06080	COG0222	ribosome binding
HRU87_06085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRU87_06090	COG0513	Belongs to the DEAD box helicase family
HRU87_06100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRU87_06120	COG0081	regulation of translation
HRU87_06125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRU87_06145	COG0436	Aminotransferase
HRU87_06160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRU87_06170	COG2030	dehydratase
HRU87_06190	COG0366	Alpha amylase catalytic
HRU87_06200	COG3833	ABC-type maltose transport systems, permease component
HRU87_06205	COG1175	transmembrane transport
HRU87_06215	COG0366	Alpha amylase catalytic
HRU87_06220	COG0366	Alpha amylase catalytic
HRU87_06225	COG2409	Drug exporters of the RND superfamily
HRU87_06265	COG1609	Transcriptional regulator
HRU87_06270	COG1666	GTP binding
HRU87_06275	COG1482	cell wall glycoprotein biosynthetic process
HRU87_06290	COG0142	geranyltranstransferase activity
HRU87_06295	COG2226	methyltransferase
HRU87_06305	COG1169	isochorismate synthase
HRU87_06310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRU87_06335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HRU87_06340	COG4948	Mandelate Racemase Muconate Lactonizing
HRU87_06345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRU87_06355	COG0785	Cytochrome C biogenesis protein
HRU87_06365	COG0406	alpha-ribazole phosphatase activity
HRU87_06370	COG0017	Asparaginyl-tRNA synthetase
HRU87_06390	COG1476	TRANSCRIPTIONal
HRU87_06415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRU87_06435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRU87_06455	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRU87_06460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRU87_06475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRU87_06490	COG0302	gtp cyclohydrolase
HRU87_06495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRU87_06500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HRU87_06505	COG0037	tRNA processing
HRU87_06510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRU87_06560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRU87_06575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRU87_06605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRU87_06665	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HRU87_06700	COG1316	TRANSCRIPTIONal
HRU87_06710	COG0561	phosphatase activity
HRU87_06715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRU87_06720	COG1597	lipid kinase activity
HRU87_06725	COG0077	Prephenate dehydratase
HRU87_06735	COG1876	peptidase activity
HRU87_06740	COG0477	Major facilitator Superfamily
HRU87_06755	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HRU87_06770	COG3590	peptidase
HRU87_06775	COG1054	Belongs to the UPF0176 family
HRU87_06785	COG2860	membrane
HRU87_06800	COG1716	ATPase activity
HRU87_06810	COG0772	Belongs to the SEDS family
HRU87_06815	COG0768	penicillin binding
HRU87_06820	COG0515	serine threonine protein kinase
HRU87_06840	COG0457	Tetratricopeptide repeat
HRU87_06840	COG0705	Rhomboid family
HRU87_06850	COG1028	Short-chain dehydrogenase reductase Sdr
HRU87_06860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRU87_06860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRU87_06860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRU87_06870	COG4115	mRNA cleavage
HRU87_06875	COG2161	toxin-antitoxin pair type II binding
HRU87_06890	COG2409	Drug exporters of the RND superfamily
HRU87_06900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRU87_06915	COG0776	regulation of translation
HRU87_06930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRU87_06935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRU87_06940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRU87_06950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRU87_06955	COG1121	(ABC) transporter
HRU87_06965	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRU87_06970	COG0022	dehydrogenase e1 component
HRU87_06985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRU87_07000	COG0305	Participates in initiation and elongation during chromosome replication
HRU87_07005	COG0359	binds to the 23S rRNA
HRU87_07010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRU87_07020	COG0360	Binds together with S18 to 16S ribosomal RNA
HRU87_07025	COG0617	tRNA 3'-terminal CCA addition
HRU87_07045	COG0492	ferredoxin-NADP+ reductase activity
HRU87_07050	COG3118	belongs to the thioredoxin family
HRU87_07055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRU87_07060	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRU87_07070	COG1192	Involved in chromosome partitioning
HRU87_07080	COG0357	Ribosomal RNA small subunit methyltransferase G
HRU87_07090	COG0706	membrane insertase activity
HRU87_07095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRU87_07100	COG0594	ribonuclease P activity
HRU87_07105	COG0230	Belongs to the bacterial ribosomal protein bL34 family