locus-tag	class	description
HRU87_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HRU87_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HRU87_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HRU87_00020	ENOG4105K7N	UPF0232 protein
HRU87_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HRU87_00030	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HRU87_00095	ENOG4105F9E	Shikimate 5-dehydrogenase
HRU87_00105	ENOG4105FDR	Membrane
HRU87_00130	ENOG4105C1G	acyl-Coa dehydrogenase
HRU87_00135	ENOG4105CHU	acetyl-coa acetyltransferase
HRU87_00140	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HRU87_00155	ENOG4105DHP	deoxycytidine triphosphate deaminase
HRU87_00180	ENOG4105CFG	Acts as a chaperone (By similarity)
HRU87_00185	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRU87_00190	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HRU87_00195	ENOG4105KNI	merR family transcriptional Regulator
HRU87_00200	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HRU87_00245	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HRU87_00260	ENOG4105EYW	Ion transport protein
HRU87_00270	ENOG4108V06	Glutathione peroxidase
HRU87_00280	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HRU87_00285	ENOG4105DQ4	alcohol dehydrogenase
HRU87_00300	ENOG4105CV8	reductase
HRU87_00320	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HRU87_00335	ENOG4105X3H	Excalibur domain protein
HRU87_00375	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HRU87_00380	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HRU87_00415	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HRU87_00420	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HRU87_00425	ENOG4105C8V	SAICAR synthetase
HRU87_00430	ENOG4105C12	Phosphoribosylglycinamide synthetase
HRU87_00435	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HRU87_00450	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HRU87_00460	ENOG4106A3M	Cytochrome p-450
HRU87_00475	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
HRU87_00480	ENOG4107Y7Q	pfkb domain protein
HRU87_00485	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HRU87_00490	ENOG4105DTD	Dehydrogenase
HRU87_00535	ENOG41085FC	arsR family transcriptional regulator
HRU87_00540	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HRU87_00565	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HRU87_00595	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HRU87_00625	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HRU87_00660	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HRU87_00670	ENOG4108Z6B	deaminase
HRU87_00680	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HRU87_00685	ENOG4105CAK	Cell division ATP-binding protein ftsE
HRU87_00695	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HRU87_00700	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HRU87_00705	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HRU87_00715	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HRU87_00720	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HRU87_00725	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HRU87_00730	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HRU87_00735	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HRU87_00740	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HRU87_00745	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HRU87_00750	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HRU87_00755	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRU87_00760	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HRU87_00765	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HRU87_00770	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HRU87_00775	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HRU87_00780	ENOG41082SA	50s ribosomal protein l29
HRU87_00785	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HRU87_00790	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HRU87_00795	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HRU87_00800	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRU87_00805	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HRU87_00810	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HRU87_00815	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HRU87_00820	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HRU87_00825	ENOG410849U	50S ribosomal protein L30
HRU87_00830	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HRU87_00835	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HRU87_00840	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HRU87_00845	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HRU87_00850	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HRU87_00855	ENOG41067V7	50S ribosomal protein L36
HRU87_00860	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRU87_00865	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HRU87_00870	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HRU87_00875	ENOG4108ZT0	50S ribosomal protein l17
HRU87_00880	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HRU87_00885	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HRU87_00890	ENOG4108UJD	30S ribosomal protein S9
HRU87_00895	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HRU87_00905	ENOG4105CS9	pantothenic acid kinase
HRU87_00910	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HRU87_00915	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HRU87_00920	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HRU87_00925	ENOG4108097	ATP-binding protein
HRU87_00930	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HRU87_00935	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HRU87_00950	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HRU87_00970	ENOG4108IV0	ABC, transporter
HRU87_00975	ENOG4105C0Z	ABC transporter
HRU87_00980	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HRU87_00985	ENOG4105CNN	ABC, transporter
HRU87_01005	ENOG4105KRI	phosphocarrier protein (HPr
HRU87_01010	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HRU87_01020	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HRU87_01035	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HRU87_01055	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HRU87_01070	ENOG4105BZ1	(ABC) transporter
HRU87_01095	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HRU87_01100	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HRU87_01110	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
HRU87_01145	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HRU87_01150	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HRU87_01165	ENOG4105C31	Tryptophanyl-tRNA synthetase
HRU87_01180	ENOG4105E33	succinate dehydrogenase
HRU87_01205	ENOG4105DIH	basic membrane
HRU87_01210	ENOG4108JQ9	ABC transporter
HRU87_01215	ENOG4105UIB	(ABC) transporter
HRU87_01235	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HRU87_01240	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
HRU87_01255	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HRU87_01270	ENOG4108JIK	carboxylase
HRU87_01275	ENOG4107WR6	Maf-like protein
HRU87_01280	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HRU87_01305	ENOG4105D8K	carboxyl transferase
HRU87_01330	ENOG4107X35	defense response to bacterium
HRU87_01335	ENOG4105CMR	udp-glucose 4-epimerase
HRU87_01340	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
HRU87_01365	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HRU87_01370	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HRU87_01375	ENOG4105BZU	Histidine kinase
HRU87_01380	ENOG4108T3R	lipoprotein lpqB
HRU87_01390	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
HRU87_01395	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HRU87_01430	ENOG4105BZ1	(ABC) transporter
HRU87_01440	ENOG4105C3R	Methionine synthase
HRU87_01455	ENOG4105DRP	amino acid AbC transporter
HRU87_01470	ENOG4107T5V	SNARE associated Golgi
HRU87_01505	ENOG4105E0A	ABC, transporter
HRU87_01510	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HRU87_01515	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HRU87_01530	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HRU87_01535	ENOG4107NHD	transcriptional regulator
HRU87_01545	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
HRU87_01560	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HRU87_01570	ENOG4105BZU	Histidine kinase
HRU87_01575	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HRU87_01585	ENOG4108VJ1	Transcriptional regulator (CarD family
HRU87_01590	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HRU87_01595	ENOG4105C8N	cysteinyl-tRNA synthetase
HRU87_01640	ENOG4108IJ0	Aspartate ammonia-lyase
HRU87_01660	ENOG4105E0X	reductase
HRU87_01670	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HRU87_01675	ENOG4105BZU	Histidine kinase
HRU87_01680	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HRU87_01700	ENOG4105VEQ	Cold shock protein
HRU87_01710	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HRU87_01755	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
HRU87_01775	ENOG4105ECP	epimerase
HRU87_01790	ENOG4105FF9	glycosyl transferase, family 39
HRU87_01800	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HRU87_01805	ENOG4105F8V	Hydrolase, tatD family
HRU87_01810	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HRU87_01815	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HRU87_01820	ENOG4105C5H	ABC transporter
HRU87_01830	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HRU87_01835	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HRU87_01845	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HRU87_01850	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HRU87_01875	ENOG4105CUT	histidyl-tRNA synthetase
HRU87_01880	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HRU87_01910	ENOG4108V0P	LemA family
HRU87_01915	ENOG4105D0M	Protease HtpX homolog
HRU87_01920	ENOG4105C7B	Threonine dehydratase
HRU87_01925	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HRU87_01945	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HRU87_01950	ENOG4108IAB	Phoh family
HRU87_01960	ENOG4105C9Q	fumarate hydratase class II
HRU87_01975	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HRU87_01980	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HRU87_01985	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HRU87_01995	ENOG4107RCW	fructose-bisphosphate aldolase
HRU87_02000	ENOG4105DE4	1-phosphofructokinase
HRU87_02015	ENOG4105C3G	gtp-binding protein
HRU87_02040	ENOG4105D7W	serine acetyltransferase
HRU87_02045	ENOG4105C6T	cysteine synthase
HRU87_02060	ENOG4105DJ2	Major Facilitator Superfamily
HRU87_02065	ENOG4107TK4	histidinol-phosphate phosphatase
HRU87_02070	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HRU87_02075	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HRU87_02080	ENOG4105EMN	RNA polymerase sigma factor
HRU87_02095	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HRU87_02110	ENOG4108JJ9	ABC, transporter
HRU87_02115	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HRU87_02125	ENOG4105DWV	Homoserine O-trans-acetylase
HRU87_02135	ENOG4105CH2	amidohydrolase
HRU87_02140	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HRU87_02150	ENOG4105E98	transcriptional regulator DeoR family
HRU87_02165	ENOG4107R3N	Filamentation induced by cAMP protein fic
HRU87_02215	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HRU87_02230	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HRU87_02245	ENOG4105D2T	synthase
HRU87_02250	ENOG4105C3I	Nad-dependent epimerase dehydratase
HRU87_02260	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HRU87_02265	ENOG4105C5E	polysaccharide biosynthesis protein
HRU87_02270	ENOG4105F0R	Cytidylyltransferase
HRU87_02295	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HRU87_02300	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HRU87_02315	ENOG4105CI3	gtp-binding protein typa
HRU87_02325	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HRU87_02340	ENOG4108Z4U	Ferredoxin
HRU87_02355	ENOG4106H78	methyltransferase
HRU87_02365	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HRU87_02375	ENOG41062IY	50S ribosomal protein L32
HRU87_02380	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HRU87_02385	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HRU87_02405	ENOG4105K5M	30s ribosomal protein S16
HRU87_02410	ENOG41084QK	UPF0109 protein
HRU87_02415	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HRU87_02420	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HRU87_02425	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HRU87_02435	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HRU87_02460	ENOG4105CE9	30S ribosomal protein S2
HRU87_02465	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HRU87_02470	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HRU87_02475	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HRU87_02480	ENOG4105KNE	Phosphatidate cytidylyltransferase
HRU87_02505	ENOG4105DSF	transport protein
HRU87_02525	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HRU87_02530	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
HRU87_02545	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HRU87_02550	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HRU87_02555	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HRU87_02560	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HRU87_02565	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HRU87_02575	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HRU87_02585	ENOG4105C26	Dehydrogenase
HRU87_02595	ENOG4108WQH	regulatoR
HRU87_02625	ENOG4105C1J	atp-dependent rna helicase
HRU87_02645	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HRU87_02670	ENOG4105S7S	phosphonate abc transporter
HRU87_02675	ENOG4105D5T	phosphonate abc transporter
HRU87_02680	ENOG4106ZX3	phosphonate ABC transporter, periplasmic phosphonate-binding protein
HRU87_02685	ENOG4105CDH	Citrulline--aspartate ligase
HRU87_02695	ENOG4105CXN	decarboxylase
HRU87_02700	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
HRU87_02720	ENOG4105DWY	Agmatine deiminase
HRU87_02730	ENOG4105DY8	decarboxylase
HRU87_02740	ENOG4105DCF	alanine dehydrogenase
HRU87_02750	ENOG41080RH	Thioredoxin
HRU87_02760	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HRU87_02765	ENOG4105VHU	single-stranded DNA-binding protein
HRU87_02775	ENOG4105C29	acyl-CoA thioesterase
HRU87_02790	ENOG4105D8X	mechanosensitive ion channel
HRU87_02800	ENOG4107S91	Sodium hydrogen exchanger
HRU87_02830	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HRU87_02835	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HRU87_02840	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HRU87_02845	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HRU87_02850	ENOG4105DKK	Benzoate
HRU87_02855	ENOG4105DGW	oligopeptidase A
HRU87_02860	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HRU87_02865	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HRU87_02870	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HRU87_02890	ENOG4105C03	ribonuclease
HRU87_02895	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HRU87_02900	ENOG4105K46	50S ribosomal protein l27
HRU87_02905	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRU87_02910	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HRU87_02915	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HRU87_02925	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HRU87_02945	ENOG41063C6	UPF0235 protein
HRU87_02950	ENOG4105DA2	glyoxalase bleomycin resistance protein dioxygenase
HRU87_02955	ENOG4105FBA	Phospholipase Carboxylesterase
HRU87_02965	ENOG4105C0B	DNA polymerase III (alpha subunit)
HRU87_02975	ENOG4108RAV	Conserved protein
HRU87_02980	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HRU87_02990	ENOG4105C8T	Leucyl-tRNA synthetase
HRU87_03000	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HRU87_03010	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HRU87_03015	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HRU87_03025	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HRU87_03030	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HRU87_03035	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HRU87_03040	ENOG4105K59	histidine triad (HIT) protein
HRU87_03050	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HRU87_03060	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HRU87_03065	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HRU87_03070	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
HRU87_03075	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HRU87_03080	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HRU87_03090	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HRU87_03095	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HRU87_03115	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HRU87_03125	ENOG4107STW	synthase
HRU87_03135	ENOG4107104	thymidine kinase
HRU87_03150	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HRU87_03155	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HRU87_03190	ENOG4105EGD	dinuclear metal center protein, YbgI family
HRU87_03225	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HRU87_03230	ENOG4105C4K	Nad synthetase
HRU87_03240	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HRU87_03245	ENOG4105C5F	glutamine synthetase
HRU87_03255	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HRU87_03260	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HRU87_03275	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HRU87_03285	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HRU87_03290	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HRU87_03305	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HRU87_03310	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HRU87_03335	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HRU87_03350	ENOG4107QM5	aconitate hydratase
HRU87_03355	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HRU87_03360	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HRU87_03390	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HRU87_03425	ENOG4105DWT	malate dehydrogenase (quinone)
HRU87_03435	ENOG4105C22	threonyL-tRNA synthetase
HRU87_03450	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
HRU87_03455	ENOG4105CDY	transcriptional regulatory protein
HRU87_03460	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HRU87_03465	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HRU87_03470	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HRU87_03475	ENOG4105VIE	preprotein translocase, subunit YajC
HRU87_03480	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HRU87_03485	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HRU87_03490	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HRU87_03510	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HRU87_03525	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HRU87_03530	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HRU87_03545	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HRU87_03550	ENOG4105D49	3-dehydroquinate synthase
HRU87_03555	ENOG4105D49	3-dehydroquinate synthase
HRU87_03560	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HRU87_03565	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HRU87_03570	ENOG410803B	Involved in the transcription termination process (By similarity)
HRU87_03575	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HRU87_03580	ENOG4105CXT	aspartate transcarbamylase
HRU87_03585	ENOG4105CD3	dihydroorotase
HRU87_03600	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HRU87_03605	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HRU87_03610	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HRU87_03615	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HRU87_03625	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HRU87_03635	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HRU87_03650	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
HRU87_03655	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HRU87_03660	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HRU87_03665	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HRU87_03685	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HRU87_03690	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HRU87_03695	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HRU87_03700	ENOG4107SYZ	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HRU87_03705	ENOG4105CBC	glutamate synthase
HRU87_03715	ENOG4105CA9	Pyruvate kinase
HRU87_03730	ENOG4105KA0	thioesterase Superfamily protein
HRU87_03740	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HRU87_03745	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HRU87_03750	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HRU87_03755	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HRU87_03765	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HRU87_03770	ENOG4105CIE	May be required for sporulation (By similarity)
HRU87_03775	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HRU87_03780	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HRU87_03785	ENOG4105BZA	Phosphoglycerate kinase
HRU87_03790	ENOG4105CP7	Triose-phosphate isomerase
HRU87_03825	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HRU87_03835	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HRU87_03840	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HRU87_03855	ENOG4105JRK	feS assembly protein SufD
HRU87_03865	ENOG4105C3K	feS assembly ATPase SufC
HRU87_03870	ENOG4105VG1	fes assembly suf system protein
HRU87_03875	ENOG4105VKD	bioY protein
HRU87_03900	ENOG4105EAC	phosphoserine phosphatase
HRU87_03905	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HRU87_03910	ENOG4107QPH	glycogen) synthase
HRU87_03915	ENOG4105DKW	ABC transporter
HRU87_03920	ENOG4105NRA	50s ribosomal protein l31 type b
HRU87_03925	ENOG4108IRC	dna polymerase iii
HRU87_03940	ENOG4107TB6	phosphoglycerate mutase
HRU87_03960	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HRU87_03970	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HRU87_03985	ENOG4108FFZ	Transcriptional regulator
HRU87_04005	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HRU87_04010	ENOG4105CQR	helicase
HRU87_04015	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HRU87_04020	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HRU87_04025	ENOG4105Q70	
HRU87_04035	ENOG4108VW9	Membrane
HRU87_04045	ENOG4107S1N	anthranilate phosphoribosyltransferase
HRU87_04050	ENOG4105CCU	oxidase (Subunit III)
HRU87_04055	ENOG4107UDY	cytochrome C
HRU87_04060	ENOG4107EUI	c reductase, iron-sulfur
HRU87_04065	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HRU87_04085	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HRU87_04090	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
HRU87_04100	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HRU87_04110	ENOG4105CPC	Aldo Keto reductase
HRU87_04115	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HRU87_04120	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HRU87_04125	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HRU87_04135	ENOG4105C0B	DNA polymerase III (alpha subunit)
HRU87_04145	ENOG4107ZIW	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HRU87_04150	ENOG4107VQS	DivIVA family
HRU87_04160	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
HRU87_04165	ENOG4105DFA	alanine racemase domain protein
HRU87_04170	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HRU87_04180	ENOG4105DFU	Cell wall formation (By similarity)
HRU87_04185	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HRU87_04190	ENOG4105CNI	cell division protein FtsW
HRU87_04195	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HRU87_04200	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HRU87_04210	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HRU87_04215	ENOG4105CJN	penicillin-binding protein
HRU87_04225	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HRU87_04230	ENOG4108V6E	Cell division protein mraZ
HRU87_04240	ENOG4105EAH	synthase
HRU87_04250	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HRU87_04260	ENOG4105DKQ	ROK family
HRU87_04270	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HRU87_04285	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
HRU87_04300	ENOG4108UW8	fha domain-containing protein
HRU87_04305	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HRU87_04310	ENOG4105SYT	Methylenetetrahydrofolate reductase
HRU87_04320	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HRU87_04325	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HRU87_04330	ENOG4105CAT	Cytidine monophosphate kinase
HRU87_04350	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HRU87_04355	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HRU87_04370	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HRU87_04375	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HRU87_04380	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HRU87_04390	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HRU87_04410	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HRU87_04415	ENOG4105CH7	arginosuccinase
HRU87_04420	ENOG4105DBV	ornithine carbamoyltransferase
HRU87_04425	ENOG4105CAS	nag kinase
HRU87_04430	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HRU87_04435	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HRU87_04440	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HRU87_04445	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HRU87_04450	ENOG4108RWN	rrna methyltransferase
HRU87_04455	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HRU87_04460	ENOG41084BS	50S ribosomal protein L35
HRU87_04465	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HRU87_04480	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HRU87_04485	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HRU87_04490	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HRU87_04495	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HRU87_04505	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HRU87_04510	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HRU87_04515	ENOG4107Y49	methyltransferase
HRU87_04520	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HRU87_04525	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HRU87_04530	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HRU87_04535	ENOG4105KC9	Modulates RecA activity (By similarity)
HRU87_04540	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HRU87_04555	ENOG4105CEV	competence damage-inducible protein
HRU87_04565	ENOG4107QZI	cell division protein FtsK
HRU87_04570	ENOG4105CN5	Metallo-Beta-Lactamase
HRU87_04575	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HRU87_04580	ENOG4105CHH	sulfate transporter
HRU87_04605	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HRU87_04610	ENOG4105C1V	Peptidase, M16
HRU87_04615	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HRU87_04620	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HRU87_04625	ENOG4105KAF	membrAne
HRU87_04630	ENOG4105DTN	riboflavin biosynthesis protein ribF
HRU87_04650	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HRU87_04670	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HRU87_04675	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HRU87_04680	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HRU87_04695	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HRU87_04700	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HRU87_04705	ENOG4105DZP	Membrane-associated zinc metalloprotease
HRU87_04710	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HRU87_04720	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HRU87_04725	ENOG4105D38	putrescine abc transporter
HRU87_04730	ENOG4105F38	ABC transporter, permease
HRU87_04735	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HRU87_04745	ENOG4105C26	Dehydrogenase
HRU87_04750	ENOG4105EW9	transcriptional regulator AsnC family
HRU87_04755	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HRU87_04765	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HRU87_04780	ENOG4107XFJ	UPF0246 protein
HRU87_04785	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HRU87_04790	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HRU87_04795	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HRU87_04800	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HRU87_04805	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HRU87_04810	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HRU87_04815	ENOG4105ZA1	atp synthase
HRU87_04820	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
HRU87_04830	ENOG4105ESV	Glycosyl transferase, family 4
HRU87_04840	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HRU87_04845	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HRU87_04855	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HRU87_04865	ENOG4105D6E	homoserine dehydrogenase
HRU87_04875	ENOG4105C75	arginyL-tRNA synthetase
HRU87_04880	ENOG4105CG3	alpha amylase, catalytic region
HRU87_04890	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
HRU87_04895	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
HRU87_04900	ENOG4105EPJ	extracellular solute-binding protein family 1
HRU87_04905	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HRU87_04910	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HRU87_04915	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HRU87_04930	ENOG4105C0H	protease
HRU87_04950	ENOG4105DJZ	UPF0182 protein
HRU87_04980	ENOG4105C4R	Atp-dependent dna helicase
HRU87_05005	ENOG4105C1J	atp-dependent rna helicase
HRU87_05010	ENOG4105DB7	PHP domain protein
HRU87_05015	ENOG4107T6F	Xaa-Pro aminopeptidase
HRU87_05025	ENOG4105CJW	magnesium transporter
HRU87_05040	ENOG4105C26	Dehydrogenase
HRU87_05050	ENOG4107ZBN	O-methyltransferase
HRU87_05060	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
HRU87_05070	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HRU87_05080	ENOG4105CPF	Cell wall formation (By similarity)
HRU87_05085	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HRU87_05095	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HRU87_05100	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HRU87_05105	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HRU87_05110	ENOG4108HH4	Major Facilitator Superfamily
HRU87_05140	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HRU87_05145	ENOG4105ERH	Fumarylacetoacetate hydrolase
HRU87_05150	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HRU87_05155	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HRU87_05170	ENOG4105XTG	Pfam:DUF156
HRU87_05175	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HRU87_05185	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HRU87_05200	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HRU87_05205	ENOG4108ZP8	Acetolactate synthase small subunit
HRU87_05215	ENOG4105C01	Dihydroxy-acid dehydratase
HRU87_05255	ENOG4105C87	Aminotransferase class I and II
HRU87_05260	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
HRU87_05290	ENOG410829K	Lysine exporter protein (Lyse ygga)
HRU87_05350	ENOG4105KRM	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
HRU87_05365	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HRU87_05370	ENOG4108RWI	nicotinamidase
HRU87_05395	ENOG4107ZYR	domain protein
HRU87_05400	ENOG4105CZN	Potassium uptake protein
HRU87_05435	ENOG4107RK0	Sucrose phosphorylase
HRU87_05450	ENOG4105EJQ	L-serine dehydratase
HRU87_05455	ENOG4105CUB	amino acid
HRU87_05465	ENOG4108Z86	Glutamine amidotransferase
HRU87_05470	ENOG4105C26	Dehydrogenase
HRU87_05475	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HRU87_05480	ENOG41073TP	transcriptional regulator
HRU87_05485	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HRU87_05510	ENOG4107QN1	sodium solute
HRU87_05525	ENOG4105C6E	dna polymerase iii
HRU87_05530	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HRU87_05535	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HRU87_05565	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HRU87_05570	ENOG4105KME	endoribonuclease L-psp
HRU87_05580	ENOG4108JQC	penicillin-binding protein 1A
HRU87_05595	ENOG4105CFH	Aspartokinase
HRU87_05600	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HRU87_05625	ENOG4105C26	Dehydrogenase
HRU87_05675	ENOG4105WH1	Two component transcriptional regulator luxr family
HRU87_05680	ENOG4105BZU	Histidine kinase
HRU87_05685	ENOG4105EYF	MMPL domain protein
HRU87_05740	ENOG4105EYF	MMPL domain protein
HRU87_05750	ENOG4105ETE	Transcriptional regulator (LacI family
HRU87_05775	ENOG4105CPC	Aldo Keto reductase
HRU87_05785	ENOG4105C2J	ABC transporter
HRU87_05790	ENOG4105CNN	ABC, transporter
HRU87_05800	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HRU87_05805	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
HRU87_05810	ENOG4107QP6	Xylose isomerase domain protein TIM barrel
HRU87_05815	ENOG4105D7K	pfkb domain protein
HRU87_05825	ENOG4105C26	Dehydrogenase
HRU87_05830	ENOG4105DH8	myo-inositol catabolism
HRU87_05835	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
HRU87_05840	ENOG4105F0H	myo-inositol catabolism protein
HRU87_05845	ENOG41090U3	tautomerase
HRU87_05855	ENOG4105DT9	hydrolase family 43
HRU87_05865	ENOG4105C93	Xylose Isomerase
HRU87_05870	ENOG4105CJQ	hydrolase, family 31
HRU87_05875	ENOG4108HWW	ABC transporter
HRU87_05880	ENOG4105C2J	ABC transporter
HRU87_05885	ENOG4105DFW	ABC transporter
HRU87_05920	ENOG4105C5H	ABC transporter
HRU87_05930	ENOG4105CQ7	ATP-dependent helicase
HRU87_05945	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HRU87_05955	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HRU87_05960	ENOG4105CGD	Nad-dependent epimerase dehydratase
HRU87_05975	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HRU87_05980	ENOG4105FDR	Membrane
HRU87_05985	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HRU87_05990	ENOG4107JTW	chlorite dismutase
HRU87_06000	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HRU87_06005	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HRU87_06010	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HRU87_06025	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HRU87_06035	ENOG4105C2C	drug resistance transporter, Bcr CflA
HRU87_06040	ENOG4105DBE	peroxidase
HRU87_06055	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
HRU87_06060	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HRU87_06070	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
HRU87_06080	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HRU87_06085	ENOG4108VZM	50s ribosomal protein L10
HRU87_06090	ENOG4105C1J	atp-dependent rna helicase
HRU87_06100	ENOG4107UVD	Beta-phosphoglucomutase family hydrolase
HRU87_06120	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HRU87_06125	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HRU87_06160	ENOG4107R4N	Cell wall formation (By similarity)
HRU87_06170	ENOG410900P	UPF0336 protein
HRU87_06190	ENOG4107R28	alpha amylase, catalytic region
HRU87_06200	ENOG4105EG2	ABC transporter, permease
HRU87_06205	ENOG4105D56	permease protein
HRU87_06215	ENOG4105CG3	alpha amylase, catalytic region
HRU87_06220	ENOG4105CG3	alpha amylase, catalytic region
HRU87_06225	ENOG4105EYF	MMPL domain protein
HRU87_06265	ENOG4105ETE	Transcriptional regulator (LacI family
HRU87_06270	ENOG4108VPT	UPF0234 protein
HRU87_06275	ENOG4105EIP	mannose-6-phosphate isomerase
HRU87_06295	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HRU87_06305	ENOG4105E4F	Isochorismate synthase
HRU87_06310	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HRU87_06335	ENOG4107SIQ	Naphthoate synthase
HRU87_06340	ENOG4107TCW	O-succinylbenzoate synthase
HRU87_06345	ENOG4105CRE	cytochrome C
HRU87_06355	ENOG4107QIV	Cytochrome c biogenesis protein
HRU87_06365	ENOG4108RH7	phosphoglycerate mutase
HRU87_06370	ENOG4105C5S	asparaginyl-tRNA synthetase
HRU87_06375	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
HRU87_06390	ENOG4105VZ8	Transcriptional regulator
HRU87_06415	ENOG4105II7	pyrroline-5-carboxylate reductase
HRU87_06455	ENOG4105CRK	lysyL-tRNA synthetase
HRU87_06460	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HRU87_06490	ENOG4105EUJ	GTP cyclohydrolase i
HRU87_06495	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HRU87_06500	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HRU87_06505	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HRU87_06510	ENOG4105F0N	pyrophosphate phospho-hydrolase
HRU87_06545	ENOG4105C57	major facilitator superfamily
HRU87_06555	ENOG4105WMR	Protein CrcB homolog
HRU87_06560	ENOG410814D	Protein CrcB homolog
HRU87_06575	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HRU87_06615	ENOG4108RCM	Nitroreductase
HRU87_06665	ENOG4105CR4	methylisocitrate lyase
HRU87_06675	ENOG4105DP8	Major facilitator superfamily MFS_1
HRU87_06700	ENOG4107TB5	TRANSCRIPTIONal
HRU87_06710	ENOG410667J	hydrolase
HRU87_06715	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HRU87_06720	ENOG4107TE5	Lipid kinase
HRU87_06725	ENOG4105CQC	Prephenate dehydratase
HRU87_06735	ENOG4108VXD	carboxy-peptidase
HRU87_06740	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HRU87_06755	ENOG4105CEC	DNA methylase N-4 N-6
HRU87_06770	ENOG4105C9K	Endothelin-converting enzyme 1
HRU87_06775	ENOG4105C72	UPF0176 protein
HRU87_06785	ENOG4107ZT3	family UPF0126
HRU87_06800	ENOG4105HZM	Fha domain containing protein
HRU87_06810	ENOG4107QHZ	cell cycle protein
HRU87_06815	ENOG4105CJN	penicillin-binding protein
HRU87_06820	ENOG4107TPY	serine threonine protein kinase
HRU87_06825	ENOG4105D9P	serine threonine protein kinase
HRU87_06840	ENOG4107ZXI	Rhomboid family
HRU87_06850	ENOG4105CHR	reductase
HRU87_06860	ENOG4105DM4	PTS System
HRU87_06870	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
HRU87_06875	ENOG4105VTW	prevent-host-death family
HRU87_06890	ENOG4107R13	MMPL domain protein
HRU87_06900	ENOG4107QUV	Domain protein
HRU87_06915	ENOG4108426	dNA-binding protein
HRU87_06920	ENOG4105DU1	integral membrane protein, terc
HRU87_06930	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HRU87_06935	ENOG4105W0E	50S ribosomal protein L33
HRU87_06940	ENOG4105KDC	50s ribosomal protein l28
HRU87_06950	ENOG4105CC5	ABC transporter
HRU87_06955	ENOG4105FDK	ABC transporter
HRU87_06965	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
HRU87_06970	ENOG4105CPP	Dehydrogenase, E1 component
HRU87_06985	ENOG4107QTF	adenylosuccinate lyase
HRU87_07000	ENOG4105CDU	Replicative dna helicase
HRU87_07005	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HRU87_07010	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HRU87_07020	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
HRU87_07025	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HRU87_07045	ENOG4105C3M	thioredoxin reductase
HRU87_07050	ENOG4105K63	Thioredoxin
HRU87_07055	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HRU87_07060	ENOG4105CPF	Cell wall formation (By similarity)
HRU87_07070	ENOG4107QJE	Chromosome Partitioning Protein
HRU87_07080	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HRU87_07090	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HRU87_07095	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HRU87_07100	ENOG41087PG	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HRU87_07105	ENOG41084CH	50S ribosomal protein l34