locus-tag	class	description
AKACHI_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKACHI_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKACHI_00040	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AKACHI_00050	COG0187	DNA topoisomerase II activity
AKACHI_00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKACHI_00210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKACHI_00210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKACHI_00210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKACHI_00220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKACHI_00220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKACHI_00220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKACHI_00240	COG0300	oxidoreductase activity
AKACHI_00270	COG1309	transcriptional regulator
AKACHI_00290	COG0457	Tetratricopeptide repeat
AKACHI_00290	COG0705	Rhomboid family
AKACHI_00330	COG0515	serine threonine protein kinase
AKACHI_00340	COG0768	penicillin binding
AKACHI_00350	COG0772	Belongs to the SEDS family
AKACHI_00370	COG1716	ATPase activity
AKACHI_00400	COG1054	Belongs to the UPF0176 family
AKACHI_00410	COG3590	peptidase
AKACHI_00440	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AKACHI_00470	COG0477	Major facilitator Superfamily
AKACHI_00480	COG1876	peptidase activity
AKACHI_00490	COG0033	Phosphoglucomutase
AKACHI_00510	COG0077	Prephenate dehydratase
AKACHI_00530	COG0745	RESPONSE REGULATOR receiver
AKACHI_00540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKACHI_00550	COG0561	phosphatase activity
AKACHI_00560	COG1316	TRANSCRIPTIONal
AKACHI_00650	COG1012	belongs to the aldehyde dehydrogenase family
AKACHI_00700	COG1136	(ABC) transporter
AKACHI_00700	COG0577	efflux transmembrane transporter activity
AKACHI_00710	COG0577	efflux transmembrane transporter activity
AKACHI_00710	COG1136	(ABC) transporter
AKACHI_00720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKACHI_00730	COG0009	L-threonylcarbamoyladenylate synthase
AKACHI_00810	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKACHI_00820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKACHI_00830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKACHI_00860	COG1175	transmembrane transport
AKACHI_00870	COG0395	ABC-type sugar transport system, permease component
AKACHI_00880	COG2124	cytochrome p450
AKACHI_00900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKACHI_00940	COG2313	pseudouridylate synthase activity
AKACHI_00950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKACHI_00970	COG1012	belongs to the aldehyde dehydrogenase family
AKACHI_00980	COG1012	belongs to the aldehyde dehydrogenase family
AKACHI_01000	COG4221	oxidoreductase activity
AKACHI_01060	COG3764	Sortase (surface protein transpeptidase)
AKACHI_01140	COG0640	Transcriptional regulator
AKACHI_01160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKACHI_01180	COG1178	ABC-type Fe3 transport system permease component
AKACHI_01250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKACHI_01260	COG1404	Belongs to the peptidase S8 family
AKACHI_01260	COG4935	Belongs to the peptidase S8 family
AKACHI_01310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKACHI_01340	COG2197	response regulator
AKACHI_01400	COG0745	RESPONSE REGULATOR receiver
AKACHI_01420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKACHI_01430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKACHI_01440	COG0590	tRNA wobble adenosine to inosine editing
AKACHI_01460	COG1216	Glycosyl transferase, family 2
AKACHI_01460	COG1442	glycosyl transferase family 8
AKACHI_01510	COG0085	RNA polymerase activity
AKACHI_01520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKACHI_01530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKACHI_01540	COG0049	tRNA binding
AKACHI_01550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKACHI_01560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKACHI_01570	COG3550	peptidyl-serine autophosphorylation
AKACHI_01600	COG0051	transcription antitermination factor activity, RNA binding
AKACHI_01610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKACHI_01620	COG0088	Forms part of the polypeptide exit tunnel
AKACHI_01630	COG0089	rRNA binding
AKACHI_01640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKACHI_01650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKACHI_01660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKACHI_01670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKACHI_01680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKACHI_01690	COG0255	Belongs to the universal ribosomal protein uL29 family
AKACHI_01700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKACHI_01710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKACHI_01720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKACHI_01730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKACHI_01740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKACHI_01750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKACHI_01760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKACHI_01770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKACHI_01780	COG1841	ribosomal large subunit assembly
AKACHI_01790	COG0200	Binds to the 23S rRNA
AKACHI_01810	COG0563	adenylate kinase activity
AKACHI_01820	COG0024	Methionine aminopeptidase
AKACHI_01830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKACHI_01840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKACHI_01850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKACHI_01860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKACHI_01870	COG0202	RNA polymerase activity
AKACHI_01880	COG0203	ribosomal protein L17
AKACHI_01890	COG0101	tRNA pseudouridine synthase activity
AKACHI_01900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKACHI_01910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKACHI_01920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKACHI_01950	COG1072	(Pantothenic acid kinase))
AKACHI_01960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKACHI_01970	COG0736	holo-[acyl-carrier-protein] synthase activity
AKACHI_01980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKACHI_01990	COG0802	atpase or kinase
AKACHI_02000	COG0456	acetyltransferase
AKACHI_02000	COG1214	PFAM Peptidase M22, glycoprotease
AKACHI_02010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKACHI_02040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKACHI_02080	COG0411	ABC transporter
AKACHI_02120	COG0516	GMP reductase activity
AKACHI_02150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKACHI_02170	COG0519	Catalyzes the synthesis of GMP from XMP
AKACHI_02170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKACHI_02200	COG0045	succinate-CoA ligase (ADP-forming) activity
AKACHI_02240	COG0138	bifunctional purine biosynthesis protein purh
AKACHI_02260	COG1132	(ABC) transporter
AKACHI_02270	COG1132	(ABC) transporter
AKACHI_02320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKACHI_02330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKACHI_02370	COG1132	(ABC) transporter
AKACHI_02390	COG1131	(ABC) transporter
AKACHI_02430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKACHI_02440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKACHI_02440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKACHI_02470	COG0180	Tryptophanyl-tRNA synthetase
AKACHI_02500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKACHI_02510	COG1053	succinate dehydrogenase
AKACHI_02530	COG2009	succinate dehydrogenase
AKACHI_02550	COG1744	ABC transporter substrate-binding protein PnrA-like
AKACHI_02560	COG3845	ABC transporter
AKACHI_02570	COG4603	Belongs to the binding-protein-dependent transport system permease family
AKACHI_02580	COG1079	Belongs to the binding-protein-dependent transport system permease family
AKACHI_02610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKACHI_02620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKACHI_02650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKACHI_02680	COG4770	biotin carboxylase activity
AKACHI_02690	COG0424	maF-like protein
AKACHI_02700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKACHI_02750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKACHI_02800	COG1388	LysM domain
AKACHI_02800	COG3942	CHAP domain
AKACHI_02810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKACHI_02870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKACHI_02880	COG0745	RESPONSE REGULATOR receiver
AKACHI_02890	COG5002	protein histidine kinase activity
AKACHI_02900	COG5401	PFAM Sporulation and spore germination
AKACHI_02910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKACHI_02920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKACHI_02930	COG0653	protein targeting
AKACHI_03010	COG2514	catechol 2,3-dioxygenase activity
AKACHI_03040	COG1280	lysine exporter protein (LysE YggA)
AKACHI_03100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKACHI_03180	COG0129	dihydroxy-acid dehydratase activity
AKACHI_03200	COG0440	acetolactate synthase activity
AKACHI_03210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AKACHI_03220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKACHI_03250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKACHI_03260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKACHI_03290	COG0473	3-isopropylmalate dehydrogenase activity
AKACHI_03300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKACHI_03310	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKACHI_03320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKACHI_03360	COG2814	Major facilitator Superfamily
AKACHI_03370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKACHI_03380	COG0066	3-isopropylmalate dehydratase activity
AKACHI_03390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKACHI_03410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKACHI_03420	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKACHI_03480	COG4122	O-methyltransferase activity
AKACHI_03490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKACHI_03500	COG1012	belongs to the aldehyde dehydrogenase family
AKACHI_03530	COG0006	proline dipeptidase activity
AKACHI_03540	COG0613	PHP domain protein
AKACHI_03550	COG0513	Belongs to the DEAD box helicase family
AKACHI_03590	COG1074	ATP-dependent DNA helicase activity
AKACHI_03620	COG0210	DNA helicase
AKACHI_03650	COG3480	Lon protease (S16) C-terminal proteolytic domain
AKACHI_03660	COG1615	UPF0182 protein
AKACHI_03690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKACHI_03720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKACHI_03730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKACHI_03740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKACHI_03750	COG1653	transport
AKACHI_03760	COG1175	transmembrane transport
AKACHI_03770	COG0395	ABC-type sugar transport system, permease component
AKACHI_03790	COG0366	Alpha amylase catalytic
AKACHI_03800	COG0018	arginyl-trna synthetase
AKACHI_03820	COG0460	homoserine dehydrogenase
AKACHI_03830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AKACHI_03840	COG0083	homoserine kinase activity
AKACHI_03860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKACHI_03870	COG2890	protein-(glutamine-N5) methyltransferase activity
AKACHI_03890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKACHI_03910	COG0356	it plays a direct role in the translocation of protons across the membrane
AKACHI_03920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKACHI_03930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKACHI_03940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKACHI_03950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKACHI_03960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKACHI_03970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKACHI_03980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKACHI_03990	COG3022	response to hydroperoxide
AKACHI_04020	COG0519	Catalyzes the synthesis of GMP from XMP
AKACHI_04050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKACHI_04070	COG1012	belongs to the aldehyde dehydrogenase family
AKACHI_04080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AKACHI_04090	COG3842	ATPase activity
AKACHI_04100	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKACHI_04110	COG1177	transmembrane transport
AKACHI_04120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKACHI_04140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKACHI_04150	COG0750	zinc metalloprotease
AKACHI_04160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKACHI_04170	COG0442	prolyl-tRNA aminoacylation
AKACHI_04180	COG0195	Participates in both transcription termination and antitermination
AKACHI_04200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKACHI_04200	COG3266	domain, Protein
AKACHI_04210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKACHI_04220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKACHI_04240	COG0573	inorganic phosphate transmembrane transporter activity
AKACHI_04260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKACHI_04300	COG0196	riboflavin kinase activity
AKACHI_04320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKACHI_04330	COG1185	polyribonucleotide nucleotidyltransferase activity
AKACHI_04340	COG0612	Peptidase, M16
AKACHI_04350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKACHI_04390	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AKACHI_04400	COG0659	secondary active sulfate transmembrane transporter activity
AKACHI_04410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKACHI_04420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKACHI_04430	COG1674	ftsk spoiiie
AKACHI_04450	COG1058	Belongs to the CinA family
AKACHI_04450	COG1546	Belongs to the CinA family
AKACHI_04480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKACHI_04490	COG2137	regulation of response to DNA damage stimulus
AKACHI_04500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKACHI_04510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKACHI_04520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKACHI_04530	COG2813	Specifically methylates the guanine in position
AKACHI_04540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKACHI_04550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKACHI_04570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKACHI_04580	COG0131	Imidazoleglycerol-phosphate dehydratase
AKACHI_04590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKACHI_04600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKACHI_04630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKACHI_04640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKACHI_04650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKACHI_04660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKACHI_04670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKACHI_04680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKACHI_04680	COG0072	phenylalanine-tRNA ligase activity
AKACHI_04690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKACHI_04700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKACHI_04710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKACHI_04720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKACHI_04730	COG0165	Argininosuccinate lyase
AKACHI_04740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKACHI_04770	COG0647	UMP catabolic process
AKACHI_04800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKACHI_04810	COG0497	DNA recombination
AKACHI_04820	COG0504	CTP synthase activity
AKACHI_04860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKACHI_04890	COG0287	Prephenate dehydrogenase
AKACHI_04900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKACHI_04910	COG1160	GTP binding
AKACHI_04920	COG0039	L-malate dehydrogenase activity
AKACHI_04950	COG1716	ATPase activity
AKACHI_04980	COG1192	Involved in chromosome partitioning
AKACHI_05030	COG1940	carbohydrate kinase activity
AKACHI_05050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AKACHI_05070	COG0142	geranyltranstransferase activity
AKACHI_05090	COG2001	Belongs to the MraZ family
AKACHI_05100	COG0275	rRNA processing
AKACHI_05120	COG0768	penicillin binding
AKACHI_05130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKACHI_05150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKACHI_05160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKACHI_05180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKACHI_05190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKACHI_05210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKACHI_05220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKACHI_05230	COG1799	cell septum assembly
AKACHI_05250	COG3599	regulation of cell shape
AKACHI_05260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKACHI_05280	COG0587	DNA-directed DNA polymerase activity
AKACHI_05300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKACHI_05310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKACHI_05320	COG0167	dihydroorotate dehydrogenase activity
AKACHI_05330	COG0667	Aldo Keto reductase
AKACHI_05350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKACHI_05370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKACHI_05380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKACHI_05400	COG1335	isochorismatase
AKACHI_05420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKACHI_05430	COG0723	plastoquinol--plastocyanin reductase activity
AKACHI_05440	COG2010	Cytochrome c
AKACHI_05450	COG1845	cytochrome c oxidase, subunit III
AKACHI_05460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKACHI_05480	COG2364	Membrane
AKACHI_05510	COG1216	Glycosyl transferase, family 2
AKACHI_05540	COG0805	protein transport
AKACHI_05550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKACHI_05580	COG2378	regulation of single-species biofilm formation
AKACHI_05590	COG0545	Peptidyl-prolyl cis-trans isomerase
AKACHI_05610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKACHI_05630	COG1968	undecaprenyl-diphosphatase activity
AKACHI_05660	COG0406	alpha-ribazole phosphatase activity
AKACHI_05700	COG0254	rRNA binding
AKACHI_05710	COG1119	ATPase activity
AKACHI_05720	COG0297	glycogen (starch) synthase activity
AKACHI_05730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AKACHI_05740	COG0560	Phosphoserine phosphatase
AKACHI_05800	COG2151	metal-sulfur cluster biosynthetic enzyme
AKACHI_05810	COG0396	ATPase activity
AKACHI_05830	COG0719	Fe-S assembly protein
AKACHI_05860	COG0415	Belongs to the DNA photolyase family
AKACHI_05870	COG0109	protoheme IX farnesyltransferase activity
AKACHI_05890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKACHI_05900	COG0166	Belongs to the GPI family
AKACHI_05930	COG0363	glucosamine-6-phosphate deaminase activity
AKACHI_05950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKACHI_05960	COG0149	triose-phosphate isomerase activity
AKACHI_05970	COG0126	phosphoglycerate kinase activity
AKACHI_05990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKACHI_06000	COG1481	regulation of sporulation
AKACHI_06010	COG1660	Displays ATPase and GTPase activities
AKACHI_06020	COG0322	excinuclease ABC activity
AKACHI_06040	COG0556	nucleotide-excision repair
AKACHI_06050	COG0237	dephospho-CoA kinase activity
AKACHI_06060	COG0539	negative regulation of cytoplasmic translation
AKACHI_06080	COG2050	protein possibly involved in aromatic compounds catabolism
AKACHI_06100	COG0469	pyruvate kinase activity
AKACHI_06120	COG0067	glutamate synthase
AKACHI_06120	COG0070	glutamate synthase
AKACHI_06120	COG0069	glutamate synthase activity
AKACHI_06130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKACHI_06140	COG0159	tryptophan synthase activity
AKACHI_06150	COG0133	tryptophan synthase activity
AKACHI_06160	COG0134	indole-3-glycerol-phosphate synthase activity
AKACHI_06200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKACHI_06210	COG0107	imidazoleglycerol-phosphate synthase activity
AKACHI_06220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKACHI_06230	COG0140	phosphoribosyl-ATP diphosphatase activity
AKACHI_06240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKACHI_06260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKACHI_06270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKACHI_06280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKACHI_06300	COG1758	RNA polymerase activity
AKACHI_06310	COG0194	GDP metabolic process
AKACHI_06320	COG0284	orotidine-5'-phosphate decarboxylase activity
AKACHI_06330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKACHI_06340	COG0505	Belongs to the CarA family
AKACHI_06360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKACHI_06370	COG0540	Belongs to the ATCase OTCase family
AKACHI_06380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AKACHI_06390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKACHI_06400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKACHI_06410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKACHI_06420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKACHI_06430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKACHI_06440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKACHI_06450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKACHI_06470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKACHI_06480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKACHI_06510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKACHI_06540	COG1196	nuclear chromosome segregation
AKACHI_06550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKACHI_06560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKACHI_06570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKACHI_06590	COG2255	four-way junction helicase activity
AKACHI_06600	COG0632	four-way junction helicase activity
AKACHI_06610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKACHI_06620	COG0217	transcriptional regulatory protein
AKACHI_06660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKACHI_06680	COG0579	oxidoreductase
AKACHI_06690	COG1525	nuclease
AKACHI_06690	COG4085	toxin activity
AKACHI_06690	COG0737	Belongs to the 5'-nucleotidase family
AKACHI_06710	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKACHI_06720	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKACHI_06780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKACHI_06790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKACHI_06820	COG0756	dUTP diphosphatase activity
AKACHI_06870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKACHI_06880	COG0187	DNA topoisomerase II activity
AKACHI_06910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKACHI_06920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKACHI_06940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKACHI_06950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKACHI_06960	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKACHI_06970	COG0321	lipoyl(octanoyl) transferase activity
AKACHI_06980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKACHI_07000	COG0174	glutamine synthetase
AKACHI_07010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKACHI_07030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKACHI_07030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKACHI_07040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKACHI_07090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKACHI_07120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AKACHI_07150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKACHI_07160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKACHI_07190	COG3046	protein related to deoxyribodipyrimidine photolyase
AKACHI_07220	COG1523	belongs to the glycosyl hydrolase 13 family
AKACHI_07250	COG0242	peptide deformylase activity
AKACHI_07310	COG0423	glycine-tRNA ligase activity
AKACHI_07320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKACHI_07330	COG1381	Involved in DNA repair and RecF pathway recombination
AKACHI_07340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKACHI_07350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKACHI_07370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKACHI_07390	COG0537	adenosine 5'-monophosphoramidase activity
AKACHI_07410	COG0484	heat shock protein binding
AKACHI_07420	COG1420	regulation of RNA biosynthetic process
AKACHI_07440	COG0481	GTPase activity
AKACHI_07450	COG0268	Binds directly to 16S ribosomal RNA
AKACHI_07470	COG1234	tRNA 3'-trailer cleavage
AKACHI_07480	COG1555	photosystem II stabilization
AKACHI_07480	COG1596	polysaccharide export
AKACHI_07490	COG0495	leucyl-tRNA aminoacylation
AKACHI_07540	COG0587	DNA-directed DNA polymerase activity
AKACHI_07560	COG0400	carboxylic ester hydrolase activity
AKACHI_07570	COG0346	lactoylglutathione lyase activity
AKACHI_07580	COG1872	DUF167
AKACHI_07590	COG0799	negative regulation of ribosome biogenesis
AKACHI_07610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKACHI_07630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKACHI_07640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKACHI_07650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKACHI_07660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKACHI_07670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKACHI_07680	COG1530	ribonuclease E activity
AKACHI_07700	COG0105	UTP biosynthetic process
AKACHI_07720	COG0285	dihydrofolate synthase activity
AKACHI_07730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKACHI_07740	COG0525	valine-tRNA ligase activity
AKACHI_07760	COG3135	benzoate transporter
AKACHI_07770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKACHI_07780	COG0740	serine-type endopeptidase activity
AKACHI_07790	COG0740	serine-type endopeptidase activity
AKACHI_07800	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKACHI_07840	COG0475	glutathione-regulated potassium exporter activity
AKACHI_07860	COG0668	transmembrane transport
AKACHI_07890	COG1946	Acyl-CoA thioesterase
AKACHI_07910	COG0629	single-stranded DNA binding
AKACHI_07920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKACHI_07940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKACHI_07960	COG0686	Belongs to the AlaDH PNT family
AKACHI_07970	COG1522	sequence-specific DNA binding
AKACHI_07990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKACHI_08000	COG2957	Belongs to the agmatine deiminase family
AKACHI_08010	COG0667	Aldo Keto reductase
AKACHI_08020	COG1982	Orn Lys Arg decarboxylase major
AKACHI_08040	COG0137	argininosuccinate synthase activity
AKACHI_08050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKACHI_08080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKACHI_08130	COG0513	Belongs to the DEAD box helicase family
AKACHI_08170	COG1012	belongs to the aldehyde dehydrogenase family
AKACHI_08180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKACHI_08190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKACHI_08200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKACHI_08210	COG0154	amidase activity
AKACHI_08220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKACHI_08230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKACHI_08240	COG0482	sulfurtransferase activity
AKACHI_08270	COG0366	Alpha amylase catalytic
AKACHI_08280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AKACHI_08380	COG0233	cytoplasmic translational termination
AKACHI_08390	COG0528	UMP kinase activity
AKACHI_08400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKACHI_08410	COG0052	Belongs to the universal ribosomal protein uS2 family
AKACHI_08430	COG4974	Belongs to the 'phage' integrase family
AKACHI_08480	COG0335	large ribosomal subunit rRNA binding
AKACHI_08490	COG2755	lipolytic protein G-D-S-L family
AKACHI_08490	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKACHI_08500	COG0336	Belongs to the RNA methyltransferase TrmD family
AKACHI_08510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKACHI_08520	COG1837	Belongs to the UPF0109 family
AKACHI_08530	COG0228	four-way junction DNA binding
AKACHI_08570	COG1217	gtp-binding protein TYPA
AKACHI_08580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKACHI_08610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKACHI_08620	COG0571	ribonuclease III activity
AKACHI_08630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKACHI_08650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKACHI_08670	COG0742	ribosomal rna small subunit methyltransferase
AKACHI_08760	COG1086	Polysaccharide biosynthesis protein
AKACHI_08780	COG0438	transferase activity, transferring glycosyl groups
AKACHI_08810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKACHI_08830	COG2884	Cell division ATP-binding protein ftsE
AKACHI_08840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKACHI_08860	COG4172	Belongs to the ABC transporter superfamily
AKACHI_08910	COG0697	spore germination
AKACHI_09020	COG1349	DNA-binding transcription factor activity
AKACHI_09040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKACHI_09050	COG1473	amidohydrolase
AKACHI_09070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKACHI_09090	COG1902	pentaerythritol trinitrate reductase activity
AKACHI_09120	COG0567	Dehydrogenase, E1 component
AKACHI_09120	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKACHI_09150	COG1595	DNA-templated transcription, initiation
AKACHI_09170	COG1162	GTPase activity
AKACHI_09180	COG0483	inositol monophosphate 1-phosphatase activity
AKACHI_09190	COG2807	transmembrane transport
AKACHI_09220	COG1045	serine acetyltransferase
AKACHI_09320	COG0012	GTP binding
AKACHI_09340	COG1322	Protein conserved in bacteria
AKACHI_09350	COG1105	Belongs to the carbohydrate kinase PfkB family
AKACHI_09360	COG0191	fructose-bisphosphate aldolase activity
AKACHI_09380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKACHI_09390	COG1570	exodeoxyribonuclease VII activity
AKACHI_09400	COG1722	exodeoxyribonuclease VII activity
AKACHI_09430	COG0114	fumarate hydratase activity
AKACHI_09450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKACHI_09510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKACHI_09520	COG0501	Belongs to the peptidase M48B family
AKACHI_09530	COG1704	LemA family
AKACHI_09580	COG0148	phosphopyruvate hydratase activity
AKACHI_09590	COG0124	histidyl-tRNA synthetase
AKACHI_09610	COG3956	TIGRFAM MazG family protein
AKACHI_09630	COG0193	aminoacyl-tRNA hydrolase activity
AKACHI_09640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKACHI_09650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKACHI_09660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKACHI_09670	COG0488	(ABC) transporter
AKACHI_09680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKACHI_09690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKACHI_09700	COG0084	hydrolase, TatD family'
AKACHI_09710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKACHI_09760	COG1090	epimerase
AKACHI_09800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKACHI_09840	COG0791	NLP P60 protein
AKACHI_09850	COG1321	iron dependent repressor
AKACHI_09880	COG1278	Cold shock
AKACHI_09920	COG0745	RESPONSE REGULATOR receiver
AKACHI_09930	COG5002	protein histidine kinase activity
AKACHI_09950	COG0459	protein refolding
AKACHI_09970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKACHI_10000	COG1027	Aspartate ammonia-lyase
AKACHI_10050	COG3842	ATPase activity
AKACHI_10080	COG0215	cysteine-tRNA ligase activity
AKACHI_10090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKACHI_10090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKACHI_10100	COG1329	Transcriptional regulator
AKACHI_10120	COG0745	RESPONSE REGULATOR receiver
AKACHI_10130	COG5002	protein histidine kinase activity
AKACHI_10150	COG0588	phosphoglycerate mutase activity
AKACHI_10170	COG0354	folic acid binding
AKACHI_10180	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AKACHI_10210	COG0745	RESPONSE REGULATOR receiver
AKACHI_10220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKACHI_10260	COG0581	inorganic phosphate transmembrane transporter activity
AKACHI_10270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKACHI_10280	COG0702	epimerase
AKACHI_10300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKACHI_10310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKACHI_10320	COG1120	ATPase activity
AKACHI_10370	COG0545	Peptidyl-prolyl cis-trans isomerase
AKACHI_10380	COG0586	Pfam SNARE associated Golgi protein
AKACHI_10390	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AKACHI_10400	COG2239	Acts as a magnesium transporter
AKACHI_10440	COG0765	amino acid transport
AKACHI_10460	COG1410	methionine synthase
AKACHI_10460	COG0646	methionine synthase
AKACHI_10480	COG3845	ABC transporter
AKACHI_10530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AKACHI_10540	COG1335	isochorismatase
AKACHI_10550	COG2027	D-alanyl-D-alanine carboxypeptidase
AKACHI_10560	COG2372	response to copper ion
AKACHI_10580	COG0569	domain protein
AKACHI_10590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKACHI_10740	COG0582	viral genome integration into host DNA
AKACHI_10790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKACHI_10820	COG0470	DNA polymerase III
AKACHI_10830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKACHI_10840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKACHI_10840	COG1754	DNA topoisomerase type I activity
AKACHI_10900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKACHI_10910	COG0251	oxidation-reduction process
AKACHI_10960	COG0527	aspartate kinase activity
AKACHI_10970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKACHI_11020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKACHI_11130	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AKACHI_11140	COG1643	Atp-dependent helicase
AKACHI_11160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKACHI_11190	COG0488	(ABC) transporter
AKACHI_11210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKACHI_11220	COG0113	porphobilinogen synthase activity
AKACHI_11240	COG0181	hydroxymethylbilane synthase activity
AKACHI_11250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKACHI_11260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKACHI_11280	COG3253	May function as heme-dependent peroxidase
AKACHI_11290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKACHI_11300	COG2409	Drug exporters of the RND superfamily
AKACHI_11370	COG5001	Diguanylate cyclase
AKACHI_11380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKACHI_11420	COG2027	D-alanyl-D-alanine carboxypeptidase
AKACHI_11430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AKACHI_11460	COG2814	Major facilitator Superfamily
AKACHI_11470	COG2837	iron assimilation
AKACHI_11500	COG1780	Probably involved in ribonucleotide reductase function
AKACHI_11510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKACHI_11560	COG0222	ribosome binding
AKACHI_11570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKACHI_11580	COG0513	Belongs to the DEAD box helicase family
AKACHI_11600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKACHI_11640	COG0745	RESPONSE REGULATOR receiver
AKACHI_11660	COG0081	regulation of translation
AKACHI_11670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKACHI_11700	COG0436	Aminotransferase
AKACHI_11710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKACHI_11730	COG2030	dehydratase
AKACHI_11750	COG0366	Alpha amylase catalytic
AKACHI_11770	COG3833	ABC-type maltose transport systems, permease component
AKACHI_11780	COG1175	transmembrane transport
AKACHI_11800	COG0366	Alpha amylase catalytic
AKACHI_11810	COG0366	Alpha amylase catalytic
AKACHI_11820	COG2409	Drug exporters of the RND superfamily
AKACHI_11850	COG1609	Transcriptional regulator
AKACHI_11860	COG1666	GTP binding
AKACHI_11870	COG1482	cell wall glycoprotein biosynthetic process
AKACHI_11900	COG0142	geranyltranstransferase activity
AKACHI_11910	COG2226	methyltransferase
AKACHI_11930	COG1169	isochorismate synthase
AKACHI_11940	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AKACHI_12000	COG4948	Mandelate Racemase Muconate Lactonizing
AKACHI_12010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKACHI_12030	COG0785	Cytochrome C biogenesis protein
AKACHI_12040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKACHI_12050	COG0406	alpha-ribazole phosphatase activity
AKACHI_12060	COG0017	Asparaginyl-tRNA synthetase
AKACHI_12140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKACHI_12160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKACHI_12180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AKACHI_12220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKACHI_12230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKACHI_12260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKACHI_12290	COG0302	gtp cyclohydrolase
AKACHI_12300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKACHI_12310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKACHI_12320	COG0037	tRNA processing
AKACHI_12330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AKACHI_12350	COG0791	NLP P60 protein
AKACHI_12350	COG3883	PFAM NLP P60 protein
AKACHI_12390	COG0477	Major facilitator Superfamily
AKACHI_12400	COG0789	Transcriptional regulator
AKACHI_12420	COG5002	protein histidine kinase activity
AKACHI_12540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKACHI_12580	COG0151	Belongs to the GarS family
AKACHI_12590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKACHI_12600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKACHI_12610	COG0509	glycine decarboxylation via glycine cleavage system
AKACHI_12620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKACHI_12620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKACHI_12640	COG2986	histidine ammonia-lyase
AKACHI_12650	COG1228	amidohydrolase
AKACHI_12660	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AKACHI_12720	COG0047	phosphoribosylformylglycinamidine synthase activity
AKACHI_12730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKACHI_12810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKACHI_12880	COG0515	serine threonine protein kinase
AKACHI_12880	COG2815	serine threonine protein kinase
AKACHI_12950	COG1404	Belongs to the peptidase S8 family
AKACHI_13100	COG2337	Toxic component of a toxin-antitoxin (TA) module
AKACHI_13110	COG2336	PFAM SpoVT AbrB
AKACHI_13120	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
AKACHI_13140	COG4214	carbohydrate transport
AKACHI_13150	COG1129	ABC transporter
AKACHI_13160	COG4213	ABC transporter substrate-binding protein
AKACHI_13190	COG1609	Transcriptional regulator
AKACHI_13220	COG2160	L-arabinose isomerase activity
AKACHI_13230	COG0667	Aldo Keto reductase
AKACHI_13260	COG1064	alcohol dehydrogenase
AKACHI_13310	COG0386	Belongs to the glutathione peroxidase family
AKACHI_13320	COG1051	belongs to the nudix hydrolase family
AKACHI_13350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKACHI_13360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKACHI_13390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKACHI_13430	COG0542	response to heat
AKACHI_13440	COG0789	Transcriptional regulator
AKACHI_13450	COG0484	heat shock protein binding
AKACHI_13460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKACHI_13470	COG0443	Heat shock 70 kDa protein
AKACHI_13500	COG2814	Major facilitator Superfamily
AKACHI_13540	COG0717	Belongs to the dCTP deaminase family
AKACHI_13570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKACHI_13600	COG0776	regulation of translation
AKACHI_13620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKACHI_13630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKACHI_13640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKACHI_13660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKACHI_13670	COG1121	(ABC) transporter
AKACHI_13690	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKACHI_13700	COG0022	dehydrogenase e1 component
AKACHI_13740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKACHI_13770	COG0305	Participates in initiation and elongation during chromosome replication
AKACHI_13780	COG0359	binds to the 23S rRNA
AKACHI_13790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKACHI_13860	COG0492	ferredoxin-NADP+ reductase activity
AKACHI_13870	COG3118	belongs to the thioredoxin family
AKACHI_13880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKACHI_13890	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKACHI_13910	COG1192	Involved in chromosome partitioning
AKACHI_13930	COG0357	Ribosomal RNA small subunit methyltransferase G
AKACHI_13950	COG0706	membrane insertase activity
AKACHI_13960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKACHI_13970	COG0230	Belongs to the bacterial ribosomal protein bL34 family