locus-tag	class	description
NBT05_00005	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NBT05_00015	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NBT05_00020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NBT05_00060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NBT05_00060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NBT05_00065	COG2356	endonuclease I
NBT05_00085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NBT05_00085	COG0047	phosphoribosylformylglycinamidine synthase activity
NBT05_00100	COG2326	polyphosphate kinase activity
NBT05_00125	COG3264	Mechanosensitive ion channel
NBT05_00125	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NBT05_00135	COG4152	abc transporter atp-binding protein
NBT05_00140	COG0484	heat shock protein binding
NBT05_00145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NBT05_00160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NBT05_00160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NBT05_00165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NBT05_00190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NBT05_00215	COG1522	sequence-specific DNA binding
NBT05_00230	COG0788	formyltetrahydrofolate deformylase activity
NBT05_00245	COG0284	orotidine-5'-phosphate decarboxylase activity
NBT05_00285	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
NBT05_00300	COG0702	epimerase
NBT05_00305	COG4771	TonB-dependent receptor
NBT05_00370	COG3335	DDE superfamily endonuclease
NBT05_00400	COG4206	TonB-dependent receptor
NBT05_00400	COG1629	transport
NBT05_00410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NBT05_00420	COG2827	Endonuclease containing a URI domain
NBT05_00435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NBT05_00465	COG2003	Belongs to the UPF0758 family
NBT05_00485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NBT05_00490	COG1162	GTPase activity
NBT05_00500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NBT05_00510	COG0436	Aminotransferase
NBT05_00515	COG0077	Prephenate dehydratase
NBT05_00515	COG1605	Chorismate mutase
NBT05_00525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NBT05_00530	COG1522	sequence-specific DNA binding
NBT05_00540	COG2198	Histidine kinase
NBT05_00540	COG0784	Response regulator, receiver
NBT05_00540	COG0643	Histidine kinase
NBT05_00545	COG3290	protein histidine kinase activity
NBT05_00560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NBT05_00580	COG1410	methionine synthase
NBT05_00580	COG0646	methionine synthase
NBT05_00610	COG0492	ferredoxin-NADP+ reductase activity
NBT05_00615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NBT05_00615	COG1648	precorrin-2 dehydrogenase activity
NBT05_00625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NBT05_00635	COG0175	sulfate reduction
NBT05_00680	COG0527	aspartate kinase activity
NBT05_00680	COG0460	homoserine dehydrogenase
NBT05_00685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NBT05_00695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NBT05_00710	COG1428	Deoxynucleoside kinase
NBT05_00735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NBT05_00755	COG0601	transmembrane transport
NBT05_00815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NBT05_00830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NBT05_00835	COG2080	2 iron, 2 sulfur cluster binding
NBT05_00840	COG2080	2 iron, 2 sulfur cluster binding
NBT05_00840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NBT05_00845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NBT05_00860	COG0321	lipoyl(octanoyl) transferase activity
NBT05_00870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NBT05_00880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NBT05_00910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NBT05_00920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NBT05_00935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NBT05_00945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NBT05_00950	COG2086	electron transfer activity
NBT05_00955	COG0022	dehydrogenase e1 component
NBT05_00955	COG0508	dehydrogenase complex catalyzes the overall conversion of
NBT05_00960	COG1629	transport
NBT05_00960	COG4206	TonB-dependent receptor
NBT05_00970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NBT05_01000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NBT05_01015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NBT05_01015	COG1333	cytochrome c biogenesis protein
NBT05_01020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NBT05_01020	COG1333	cytochrome c biogenesis protein
NBT05_01060	COG3852	Histidine kinase
NBT05_01065	COG2204	response regulator
NBT05_01075	COG1136	(ABC) transporter
NBT05_01080	COG0577	efflux transmembrane transporter activity
NBT05_01080	COG1136	(ABC) transporter
NBT05_01085	COG1295	ribonuclease BN
NBT05_01090	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
NBT05_01135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NBT05_01170	COG3292	Two component regulator propeller
NBT05_01170	COG2205	protein histidine kinase activity
NBT05_01170	COG0745	RESPONSE REGULATOR receiver
NBT05_01220	COG0783	Belongs to the Dps family
NBT05_01245	COG1012	belongs to the aldehyde dehydrogenase family
NBT05_01260	COG0745	RESPONSE REGULATOR receiver
NBT05_01265	COG4251	negative regulation of phosphorylation
NBT05_01270	COG1917	Cupin 2, conserved barrel domain protein
NBT05_01270	COG2207	Transcriptional regulator
NBT05_01275	COG2201	protein-glutamate methylesterase activity
NBT05_01280	COG1482	cell wall glycoprotein biosynthetic process
NBT05_01285	COG0778	Nitroreductase
NBT05_01300	COG0745	RESPONSE REGULATOR receiver
NBT05_01300	COG3292	Two component regulator propeller
NBT05_01300	COG2205	protein histidine kinase activity
NBT05_01325	COG1741	Belongs to the pirin family
NBT05_01330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NBT05_01365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NBT05_01370	COG1388	LysM domain
NBT05_01400	COG3842	ATPase activity
NBT05_01415	COG0629	single-stranded DNA binding
NBT05_01420	COG1309	transcriptional regulator
NBT05_01475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NBT05_01490	COG1428	Deoxynucleoside kinase
NBT05_01540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NBT05_01550	COG0544	peptidyl-prolyl cis-trans isomerase activity
NBT05_01570	COG0596	Alpha beta hydrolase
NBT05_01580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NBT05_01590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NBT05_01600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NBT05_01620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NBT05_01645	COG1214	PFAM Peptidase M22, glycoprotease
NBT05_01660	COG0577	efflux transmembrane transporter activity
NBT05_01660	COG1136	(ABC) transporter
NBT05_01665	COG1136	(ABC) transporter
NBT05_01665	COG0577	efflux transmembrane transporter activity
NBT05_01670	COG1136	(ABC) transporter
NBT05_01680	COG2322	membrane
NBT05_01685	COG1999	signal sequence binding
NBT05_01705	COG1845	cytochrome c oxidase, subunit III
NBT05_01710	COG0109	protoheme IX farnesyltransferase activity
NBT05_01730	COG0509	glycine decarboxylation via glycine cleavage system
NBT05_01740	COG0632	four-way junction helicase activity
NBT05_01745	COG0280	phosphate acetyltransferase
NBT05_01745	COG0281	malic enzyme
NBT05_01750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NBT05_01760	COG2255	four-way junction helicase activity
NBT05_01770	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
NBT05_01785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NBT05_01790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NBT05_01810	COG0052	Belongs to the universal ribosomal protein uS2 family
NBT05_01815	COG0437	4 iron, 4 sulfur cluster binding
NBT05_01830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NBT05_01835	COG0195	Participates in both transcription termination and antitermination
NBT05_01840	COG0779	Required for maturation of 30S ribosomal subunits
NBT05_01850	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
NBT05_01865	COG1842	Phage shock protein A
NBT05_01885	COG2852	Protein conserved in bacteria
NBT05_01890	COG2255	four-way junction helicase activity
NBT05_01950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NBT05_01950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NBT05_01975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NBT05_01980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NBT05_01985	COG0052	Belongs to the universal ribosomal protein uS2 family
NBT05_01990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NBT05_01995	COG0528	UMP kinase activity
NBT05_02000	COG0233	cytoplasmic translational termination
NBT05_02010	COG0017	Asparaginyl-tRNA synthetase
NBT05_02050	COG0811	peptide transport
NBT05_02060	COG0252	asparaginase activity
NBT05_02065	COG0084	hydrolase, TatD family'
NBT05_02080	COG0138	bifunctional purine biosynthesis protein purh
NBT05_02085	COG1077	Cell shape determining protein MreB Mrl
NBT05_02100	COG0768	penicillin binding
NBT05_02105	COG0772	Belongs to the SEDS family
NBT05_02120	COG3275	phosphorelay sensor kinase activity
NBT05_02125	COG3279	Response regulator of the LytR AlgR family
NBT05_02130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NBT05_02135	COG0793	Belongs to the peptidase S41A family
NBT05_02140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NBT05_02150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NBT05_02155	COG0791	NLP P60 protein
NBT05_02160	COG2333	competence protein COMEC
NBT05_02160	COG0658	competence protein
NBT05_02180	COG3104	oligopeptide transport
NBT05_02185	COG0823	Involved in the tonB-independent uptake of proteins
NBT05_02185	COG1506	peptidase
NBT05_02205	COG0508	dehydrogenase complex catalyzes the overall conversion of
NBT05_02220	COG0567	Dehydrogenase, E1 component
NBT05_02230	COG0142	geranyltranstransferase activity
NBT05_02250	COG1309	transcriptional regulator
NBT05_02270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NBT05_02305	COG1629	transport
NBT05_02350	COG1595	DNA-templated transcription, initiation
NBT05_02355	COG0384	phenazine biosynthesis protein PhzF
NBT05_02380	COG3292	Two component regulator propeller
NBT05_02380	COG2205	protein histidine kinase activity
NBT05_02380	COG0745	RESPONSE REGULATOR receiver
NBT05_02410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NBT05_02415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NBT05_02420	COG0193	aminoacyl-tRNA hydrolase activity
NBT05_02425	COG0196	riboflavin kinase activity
NBT05_02435	COG3609	addiction module antidote protein, CC2985 family
NBT05_02445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NBT05_02460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NBT05_02465	COG2239	Acts as a magnesium transporter
NBT05_02685	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NBT05_02690	COG1518	maintenance of DNA repeat elements
NBT05_02695	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
NBT05_02720	COG4974	Belongs to the 'phage' integrase family
NBT05_02740	COG3328	transposase activity
NBT05_02745	COG3328	transposase activity
NBT05_02810	COG0488	(ABC) transporter
NBT05_02840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NBT05_02860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NBT05_02895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NBT05_02900	COG0459	protein refolding
NBT05_02920	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NBT05_02945	COG4771	TonB-dependent receptor
NBT05_02950	COG0702	epimerase
NBT05_02965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NBT05_02970	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NBT05_02975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NBT05_02985	COG1253	flavin adenine dinucleotide binding
NBT05_03010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NBT05_03080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NBT05_03085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NBT05_03090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NBT05_03100	COG0071	Belongs to the small heat shock protein (HSP20) family
NBT05_03110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NBT05_03215	COG1472	Belongs to the glycosyl hydrolase 3 family
NBT05_03220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NBT05_03225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NBT05_03230	COG2080	2 iron, 2 sulfur cluster binding
NBT05_03250	COG1215	transferase activity, transferring glycosyl groups
NBT05_03260	COG1187	pseudouridine synthase activity
NBT05_03285	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NBT05_03290	COG1309	transcriptional regulator
NBT05_03295	COG2081	HI0933 family
NBT05_03300	COG0584	glycerophosphoryl diester phosphodiesterase
NBT05_03305	COG1960	acyl-CoA dehydrogenase activity
NBT05_03325	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
NBT05_03335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NBT05_03340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NBT05_03345	COG0228	four-way junction DNA binding
NBT05_03460	COG3422	double-strand break repair
NBT05_03550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NBT05_03555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NBT05_03565	COG3177	Filamentation induced by cAMP protein fic
NBT05_03585	COG2315	Protein conserved in bacteria
NBT05_03590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NBT05_03620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NBT05_03645	COG0800	Aldolase
NBT05_03655	COG0489	protein tyrosine kinase activity
NBT05_03670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NBT05_03675	COG5002	protein histidine kinase activity
NBT05_03680	COG0745	RESPONSE REGULATOR receiver
NBT05_03700	COG1629	transport
NBT05_03715	COG1629	transport
NBT05_03740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NBT05_03760	COG2204	response regulator
NBT05_03770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NBT05_03800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NBT05_03810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NBT05_03815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NBT05_03825	COG0537	adenosine 5'-monophosphoramidase activity
NBT05_03835	COG3852	Histidine kinase
NBT05_03840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NBT05_03850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NBT05_03855	COG0519	Catalyzes the synthesis of GMP from XMP
NBT05_03870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NBT05_03875	COG1968	undecaprenyl-diphosphatase activity
NBT05_03880	COG0384	phenazine biosynthesis protein PhzF
NBT05_03920	COG0156	8-amino-7-oxononanoate synthase activity
NBT05_03930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NBT05_03935	COG0653	protein targeting
NBT05_03940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NBT05_03955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NBT05_03965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NBT05_03985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NBT05_04065	COG1012	belongs to the aldehyde dehydrogenase family
NBT05_04075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NBT05_04080	COG2897	thiosulfate sulfurtransferase activity
NBT05_04100	COG1607	acyl-coa hydrolase
NBT05_04120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NBT05_04125	COG0756	dUTP diphosphatase activity
NBT05_04145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NBT05_04155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NBT05_04160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NBT05_04165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NBT05_04170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NBT05_04175	COG0356	it plays a direct role in the translocation of protons across the membrane
NBT05_04180	COG0439	Biotin carboxylase
NBT05_04185	COG0511	ligase activity, forming carbon-carbon bonds
NBT05_04190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NBT05_04195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NBT05_04205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NBT05_04225	COG1530	ribonuclease E activity
NBT05_04230	COG0776	regulation of translation
NBT05_04270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NBT05_04285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NBT05_04300	COG0659	secondary active sulfate transmembrane transporter activity
NBT05_04310	COG0659	secondary active sulfate transmembrane transporter activity
NBT05_04315	COG0495	leucyl-tRNA aminoacylation
NBT05_04330	COG2177	Part of the ABC transporter FtsEX involved in
NBT05_04335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NBT05_04375	COG1404	Belongs to the peptidase S8 family
NBT05_04395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NBT05_04425	COG0305	Participates in initiation and elongation during chromosome replication
NBT05_04450	COG2337	Toxic component of a toxin-antitoxin (TA) module
NBT05_04485	COG0534	Mate efflux family protein
NBT05_04490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NBT05_04495	COG0720	synthase
NBT05_04510	COG0596	Alpha beta hydrolase
NBT05_04520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NBT05_04520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NBT05_04530	COG1573	uracil-dna glycosylase
NBT05_04535	COG5654	RES domain protein
NBT05_04545	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NBT05_04555	COG1435	thymidine kinase activity
NBT05_04560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NBT05_04565	COG1970	mechanosensitive ion channel activity
NBT05_04570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NBT05_04575	COG1505	serine-type exopeptidase activity
NBT05_04580	COG3842	ATPase activity
NBT05_04655	COG3501	Rhs element vgr protein
NBT05_04715	COG3335	DDE superfamily endonuclease
NBT05_04730	COG3335	DDE superfamily endonuclease
NBT05_04785	COG3341	Caulimovirus viroplasmin
NBT05_04785	COG0328	RNA-DNA hybrid ribonuclease activity
NBT05_04790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NBT05_04795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NBT05_04805	COG0571	ribonuclease III activity
NBT05_04815	COG0469	pyruvate kinase activity
NBT05_04825	COG5002	protein histidine kinase activity
NBT05_04840	COG0006	proline dipeptidase activity
NBT05_04845	COG1114	Component of the transport system for branched-chain amino acids
NBT05_04860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NBT05_04865	COG0316	Belongs to the HesB IscA family
NBT05_04870	COG0719	Fe-S assembly protein
NBT05_04880	COG0396	ATPase activity
NBT05_04885	COG0719	Fe-S assembly protein
NBT05_04890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NBT05_04900	COG2166	iron-sulfur cluster assembly
NBT05_04905	COG2151	metal-sulfur cluster biosynthetic enzyme
NBT05_04925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NBT05_04975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NBT05_04990	COG0594	ribonuclease P activity
NBT05_04995	COG0793	Belongs to the peptidase S41A family
NBT05_05005	COG2153	protein acetylation
NBT05_05010	COG0698	ribose 5-phosphate isomerase
NBT05_05020	COG0557	exoribonuclease II activity
NBT05_05045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NBT05_05060	COG0330	HflC and HflK could
NBT05_05075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NBT05_05085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NBT05_05090	COG0445	tRNA wobble uridine modification
NBT05_05130	COG0470	DNA polymerase III
NBT05_05135	COG0126	phosphoglycerate kinase activity
NBT05_05140	COG1388	LysM domain
NBT05_05140	COG0741	lytic transglycosylase activity
NBT05_05150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NBT05_05155	COG0739	heme binding
NBT05_05185	COG2244	polysaccharide biosynthetic process
NBT05_05210	COG1215	transferase activity, transferring glycosyl groups
NBT05_05215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NBT05_05275	COG0275	rRNA processing
NBT05_05290	COG0438	transferase activity, transferring glycosyl groups
NBT05_05365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NBT05_05395	COG0750	zinc metalloprotease
NBT05_05400	COG1999	signal sequence binding
NBT05_05415	COG1233	COG1233 Phytoene dehydrogenase and related
NBT05_05455	COG1418	mRNA catabolic process
NBT05_05470	COG1446	asparaginase
NBT05_05495	COG2954	triphosphatase activity
NBT05_05505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NBT05_05515	COG1053	succinate dehydrogenase
NBT05_05550	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NBT05_05555	COG0123	including yeast histone deacetylase and acetoin utilization protein
NBT05_05560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NBT05_05560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NBT05_05565	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NBT05_05590	COG1619	proteins homologs of microcin C7 resistance protein MccF
NBT05_05595	COG0792	nuclease activity
NBT05_05600	COG0667	Aldo Keto reductase
NBT05_05625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NBT05_05655	COG1201	RNA secondary structure unwinding
NBT05_05660	COG1793	dna ligase
NBT05_05700	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NBT05_05775	COG4172	Belongs to the ABC transporter superfamily
NBT05_05780	COG5000	phosphorelay sensor kinase activity
NBT05_05785	COG1024	Enoyl-CoA hydratase
NBT05_05790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NBT05_05800	COG0194	GDP metabolic process
NBT05_05805	COG1561	YicC-like family, N-terminal region
NBT05_05810	COG1981	membrane
NBT05_05825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NBT05_05840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NBT05_05845	COG0181	hydroxymethylbilane synthase activity
NBT05_05850	COG3657	addiction module killer protein
NBT05_05855	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NBT05_05865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NBT05_05875	COG0408	coproporphyrinogen oxidase activity
NBT05_05900	COG4555	ABC transporter
NBT05_05905	COG0113	porphobilinogen synthase activity
NBT05_05915	COG1253	flavin adenine dinucleotide binding
NBT05_05945	COG4221	oxidoreductase activity
NBT05_05950	COG0714	Associated with various cellular activities
NBT05_05965	COG2304	oxidoreductase activity
NBT05_05970	COG2304	oxidoreductase activity
NBT05_05995	COG0686	Belongs to the AlaDH PNT family
NBT05_06005	COG1522	sequence-specific DNA binding
NBT05_06015	COG2363	Small membrane protein
NBT05_06030	COG0463	Glycosyl transferase, family 2
NBT05_06035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NBT05_06070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NBT05_06080	COG1774	PSP1 C-terminal conserved region
NBT05_06090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NBT05_06100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NBT05_06105	COG0450	alkyl hydroperoxide reductase
NBT05_06135	COG0626	cystathionine gamma-synthase activity
NBT05_06140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NBT05_06150	COG1381	Involved in DNA repair and RecF pathway recombination
NBT05_06155	COG4771	TonB-dependent receptor
NBT05_06175	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NBT05_06200	COG0010	Belongs to the arginase family
NBT05_06205	COG0189	ligase activity
NBT05_06210	COG0668	transmembrane transport
NBT05_06230	COG1404	Belongs to the peptidase S8 family
NBT05_06270	COG2852	Protein conserved in bacteria
NBT05_06280	COG2137	regulation of response to DNA damage stimulus
NBT05_06285	COG4591	ABC-type transport system involved in lipoprotein release permease component
NBT05_06310	COG0481	GTPase activity
NBT05_06315	COG0561	phosphatase activity
NBT05_06425	COG1505	serine-type exopeptidase activity
NBT05_06430	COG1505	serine-type exopeptidase activity
NBT05_06485	COG0305	Participates in initiation and elongation during chromosome replication
NBT05_06535	COG0166	Belongs to the GPI family
NBT05_06540	COG0739	heme binding
NBT05_06545	COG3483	tryptophan 2,3-dioxygenase activity
NBT05_06555	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NBT05_06575	COG4115	mRNA cleavage
NBT05_06590	COG0322	excinuclease ABC activity
NBT05_06600	COG0189	ligase activity
NBT05_06610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NBT05_06615	COG2201	protein-glutamate methylesterase activity
NBT05_06620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NBT05_06630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NBT05_06660	COG0423	glycine-tRNA ligase activity
NBT05_06675	COG0708	Exodeoxyribonuclease III
NBT05_06690	COG0667	Aldo Keto reductase
NBT05_06695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NBT05_06710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NBT05_06715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NBT05_06720	COG0297	glycogen (starch) synthase activity
NBT05_06730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NBT05_06735	COG4771	TonB-dependent receptor
NBT05_06740	COG4771	TonB-dependent receptor
NBT05_06765	COG2274	protein secretion by the type I secretion system
NBT05_06805	COG1770	oligopeptidase
NBT05_06810	COG1404	Belongs to the peptidase S8 family
NBT05_06840	COG2267	carboxylic ester hydrolase activity
NBT05_06885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NBT05_06895	COG0668	transmembrane transport
NBT05_06925	COG2095	MarC family integral membrane protein
NBT05_06950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NBT05_06950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NBT05_06960	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NBT05_06965	COG3119	arylsulfatase activity
NBT05_06975	COG0702	epimerase
NBT05_06980	COG4771	TonB-dependent receptor
NBT05_06985	COG5434	Belongs to the glycosyl hydrolase 28 family
NBT05_06990	COG3119	arylsulfatase activity
NBT05_07000	COG2205	protein histidine kinase activity
NBT05_07000	COG0745	RESPONSE REGULATOR receiver
NBT05_07000	COG3292	Two component regulator propeller
NBT05_07005	COG5434	Belongs to the glycosyl hydrolase 28 family
NBT05_07010	COG3250	beta-galactosidase activity
NBT05_07015	COG3250	beta-galactosidase activity
NBT05_07020	COG3119	arylsulfatase activity
NBT05_07025	COG3119	arylsulfatase activity
NBT05_07030	COG3408	Glycogen debranching enzyme
NBT05_07030	COG3119	arylsulfatase activity
NBT05_07035	COG3119	arylsulfatase activity
NBT05_07045	COG3119	arylsulfatase activity
NBT05_07060	COG3119	arylsulfatase activity
NBT05_07095	COG3119	arylsulfatase activity
NBT05_07125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NBT05_07135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NBT05_07145	COG3328	transposase activity
NBT05_07160	COG3328	transposase activity
NBT05_07175	COG0784	Response regulator, receiver
NBT05_07205	COG3279	Response regulator of the LytR AlgR family
NBT05_07230	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
NBT05_07285	COG2207	Transcriptional regulator
NBT05_07300	COG1595	DNA-templated transcription, initiation
NBT05_07330	COG0066	3-isopropylmalate dehydratase activity
NBT05_07335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NBT05_07360	COG1122	ATPase activity
NBT05_07365	COG4771	TonB-dependent receptor
NBT05_07370	COG0702	epimerase
NBT05_07380	COG3119	arylsulfatase activity
NBT05_07395	COG1472	Belongs to the glycosyl hydrolase 3 family
NBT05_07405	COG3119	arylsulfatase activity
NBT05_07445	COG3119	arylsulfatase activity
NBT05_07465	COG3250	beta-galactosidase activity
NBT05_07470	COG3250	beta-galactosidase activity
NBT05_07475	COG3408	Glycogen debranching enzyme
NBT05_07475	COG3119	arylsulfatase activity
NBT05_07480	COG0745	RESPONSE REGULATOR receiver
NBT05_07480	COG2205	protein histidine kinase activity
NBT05_07480	COG3292	Two component regulator propeller
NBT05_07485	COG1063	alcohol dehydrogenase
NBT05_07490	COG2721	sulfolactate sulfo-lyase activity
NBT05_07495	COG0246	Mannitol dehydrogenase
NBT05_07505	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_07510	COG0738	Major facilitator superfamily
NBT05_07515	COG3254	rhamnose metabolic process
NBT05_07525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NBT05_07535	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_07565	COG4585	Histidine kinase
NBT05_07595	COG1404	Belongs to the peptidase S8 family
NBT05_07600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NBT05_07605	COG4935	Belongs to the peptidase S8 family
NBT05_07605	COG1404	Belongs to the peptidase S8 family
NBT05_07610	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NBT05_07620	COG1970	mechanosensitive ion channel activity
NBT05_07625	COG0745	RESPONSE REGULATOR receiver
NBT05_07625	COG2205	protein histidine kinase activity
NBT05_07625	COG3292	Two component regulator propeller
NBT05_07660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NBT05_07665	COG0401	homolog of Blt101
NBT05_07685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NBT05_07740	COG0149	triose-phosphate isomerase activity
NBT05_07745	COG2308	Evidence 4 Homologs of previously reported genes of
NBT05_07765	COG2307	Protein conserved in bacteria
NBT05_07765	COG2308	Evidence 4 Homologs of previously reported genes of
NBT05_07795	COG1216	Glycosyl transferase, family 2
NBT05_07805	COG1960	acyl-CoA dehydrogenase activity
NBT05_07815	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NBT05_07820	COG0811	peptide transport
NBT05_07825	COG0848	biopolymer transport protein
NBT05_07835	COG0285	dihydrofolate synthase activity
NBT05_07880	COG1204	response to ionizing radiation
NBT05_07900	COG2382	esterase
NBT05_07940	COG1294	oxidase, subunit
NBT05_07945	COG1271	oxidase subunit
NBT05_07955	COG0010	Belongs to the arginase family
NBT05_08020	COG0598	Magnesium transport protein CorA
NBT05_08035	COG3279	Response regulator of the LytR AlgR family
NBT05_08040	COG0745	RESPONSE REGULATOR receiver
NBT05_08040	COG2972	Histidine kinase
NBT05_08060	COG0415	Belongs to the DNA photolyase family
NBT05_08065	COG3046	protein related to deoxyribodipyrimidine photolyase
NBT05_08070	COG0415	Belongs to the DNA photolyase family
NBT05_08080	COG0784	Response regulator, receiver
NBT05_08080	COG2198	Histidine kinase
NBT05_08080	COG2205	protein histidine kinase activity
NBT05_08085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NBT05_08090	COG1160	GTP binding
NBT05_08130	COG0739	heme binding
NBT05_08135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NBT05_08150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NBT05_08170	COG0295	cytidine deaminase activity
NBT05_08175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NBT05_08180	COG0508	dehydrogenase complex catalyzes the overall conversion of
NBT05_08190	COG2234	aminopeptidase activity
NBT05_08195	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_08225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NBT05_08235	COG1216	Glycosyl transferase, family 2
NBT05_08290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NBT05_08290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NBT05_08315	COG0415	Belongs to the DNA photolyase family
NBT05_08320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NBT05_08325	COG0693	protein deglycase activity
NBT05_08345	COG0778	Nitroreductase
NBT05_08365	COG0668	transmembrane transport
NBT05_08375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NBT05_08380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NBT05_08390	COG0563	adenylate kinase activity
NBT05_08395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NBT05_08410	COG2373	Large extracellular alpha-helical protein
NBT05_08415	COG1490	D-aminoacyl-tRNA deacylase activity
NBT05_08435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NBT05_08445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NBT05_08455	COG1595	DNA-templated transcription, initiation
NBT05_08480	COG0358	DNA primase activity
NBT05_08490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NBT05_08505	COG4682	membrane
NBT05_08520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NBT05_08525	COG2267	carboxylic ester hydrolase activity
NBT05_08530	COG2001	Belongs to the MraZ family
NBT05_08535	COG0275	rRNA processing
NBT05_08545	COG0768	penicillin binding
NBT05_08550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NBT05_08555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NBT05_08560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NBT05_08565	COG0772	Belongs to the SEDS family
NBT05_08570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NBT05_08575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NBT05_08590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NBT05_08595	COG1610	YqeY-like protein
NBT05_08605	COG2311	Membrane
NBT05_08610	COG4771	TonB-dependent receptor
NBT05_08615	COG0702	epimerase
NBT05_08630	COG2095	MarC family integral membrane protein
NBT05_08665	COG0492	ferredoxin-NADP+ reductase activity
NBT05_08670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NBT05_08680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NBT05_08700	COG1185	polyribonucleotide nucleotidyltransferase activity
NBT05_08705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NBT05_08720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NBT05_08725	COG0191	fructose-bisphosphate aldolase activity
NBT05_08735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NBT05_08745	COG2226	methyltransferase
NBT05_08750	COG0569	domain protein
NBT05_08755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NBT05_08760	COG0436	Aminotransferase
NBT05_08765	COG3239	Fatty acid desaturase
NBT05_08770	COG0357	Ribosomal RNA small subunit methyltransferase G
NBT05_08790	COG0300	oxidoreductase activity
NBT05_08795	COG1012	belongs to the aldehyde dehydrogenase family
NBT05_08810	COG2967	ApaG domain
NBT05_08825	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NBT05_08830	COG1805	sodium ion transport
NBT05_08835	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NBT05_08840	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NBT05_08845	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NBT05_08860	COG1477	protein flavinylation
NBT05_08885	COG2226	methyltransferase
NBT05_08900	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NBT05_08910	COG0501	Belongs to the peptidase M48B family
NBT05_08925	COG0740	serine-type endopeptidase activity
NBT05_08950	COG1696	Membrane protein involved in D-alanine export
NBT05_08995	COG0561	phosphatase activity
NBT05_09000	COG4771	TonB-dependent receptor
NBT05_09065	COG0662	Cupin 2, conserved barrel domain protein
NBT05_09065	COG2207	Transcriptional regulator
NBT05_09075	COG0633	Ferredoxin
NBT05_09080	COG2124	cytochrome p450
NBT05_09100	COG3250	beta-galactosidase activity
NBT05_09110	COG1063	alcohol dehydrogenase
NBT05_09115	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_09120	COG1012	belongs to the aldehyde dehydrogenase family
NBT05_09125	COG4948	Mandelate Racemase Muconate Lactonizing
NBT05_09130	COG2017	converts alpha-aldose to the beta-anomer
NBT05_09140	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NBT05_09170	COG4447	cellulose binding
NBT05_09230	COG3385	transposase activity
NBT05_09255	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NBT05_09305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NBT05_09335	COG0577	efflux transmembrane transporter activity
NBT05_09335	COG1136	(ABC) transporter
NBT05_09340	COG1136	(ABC) transporter
NBT05_09365	COG3335	DDE superfamily endonuclease
NBT05_09385	COG3328	transposase activity
NBT05_09410	COG1629	transport
NBT05_09420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NBT05_09425	COG0049	tRNA binding
NBT05_09430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NBT05_09435	COG0051	transcription antitermination factor activity, RNA binding
NBT05_09440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NBT05_09445	COG0088	Forms part of the polypeptide exit tunnel
NBT05_09450	COG0089	rRNA binding
NBT05_09455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NBT05_09460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NBT05_09465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NBT05_09470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NBT05_09475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NBT05_09480	COG0255	Belongs to the universal ribosomal protein uL29 family
NBT05_09485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NBT05_09490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NBT05_09495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NBT05_09500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NBT05_09505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NBT05_09510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NBT05_09515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NBT05_09520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NBT05_09525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NBT05_09530	COG1841	ribosomal large subunit assembly
NBT05_09535	COG0200	Binds to the 23S rRNA
NBT05_09545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NBT05_09550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NBT05_09555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NBT05_09560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NBT05_09565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NBT05_09570	COG0202	RNA polymerase activity
NBT05_09575	COG0203	ribosomal protein L17
NBT05_09580	COG0505	Belongs to the CarA family
NBT05_09585	COG0148	phosphopyruvate hydratase activity
NBT05_09605	COG1959	2 iron, 2 sulfur cluster binding
NBT05_09610	COG1090	epimerase
NBT05_09620	COG0018	arginyl-trna synthetase
NBT05_09650	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NBT05_09660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NBT05_09665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NBT05_09695	COG0101	tRNA pseudouridine synthase activity
NBT05_09700	COG1132	(ABC) transporter
NBT05_09705	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NBT05_09710	COG2264	protein methyltransferase activity
NBT05_09725	COG0303	'Molybdopterin
NBT05_09735	COG0746	molybdenum cofactor guanylyltransferase activity
NBT05_09745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NBT05_09750	COG0314	molybdopterin synthase activity
NBT05_09755	COG0315	cyclic pyranopterin monophosphate synthase activity
NBT05_09755	COG0521	Mo-molybdopterin cofactor biosynthetic process
NBT05_09760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NBT05_09810	COG0438	transferase activity, transferring glycosyl groups
NBT05_09845	COG0159	tryptophan synthase activity
NBT05_09850	COG0133	tryptophan synthase activity
NBT05_09860	COG0135	phosphoribosylanthranilate isomerase activity
NBT05_09870	COG0134	indole-3-glycerol-phosphate synthase activity
NBT05_09875	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NBT05_09880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NBT05_09885	COG0512	Glutamine amidotransferase of anthranilate synthase
NBT05_09890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NBT05_09895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NBT05_09905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NBT05_09910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NBT05_09935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NBT05_09945	COG1703	isobutyryl-CoA mutase activity
NBT05_09950	COG1764	response to oxidative stress
NBT05_09990	COG0653	protein targeting
NBT05_10010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NBT05_10025	COG0508	dehydrogenase complex catalyzes the overall conversion of
NBT05_10055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NBT05_10060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NBT05_10065	COG1121	(ABC) transporter
NBT05_10070	COG0803	Belongs to the bacterial solute-binding protein 9 family
NBT05_10085	COG2176	DNA-directed DNA polymerase activity
NBT05_10085	COG5002	protein histidine kinase activity
NBT05_10090	COG0179	Fumarylacetoacetate (FAA) hydrolase
NBT05_10100	COG1058	Belongs to the CinA family
NBT05_10100	COG1546	Belongs to the CinA family
NBT05_10105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NBT05_10110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NBT05_10120	COG0552	protein localization to endoplasmic reticulum
NBT05_10135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NBT05_10140	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NBT05_10155	COG0519	Catalyzes the synthesis of GMP from XMP
NBT05_10155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NBT05_10160	COG3942	CHAP domain
NBT05_10160	COG1388	LysM domain
NBT05_10175	COG0019	diaminopimelate decarboxylase activity
NBT05_10185	COG0045	succinate-CoA ligase (ADP-forming) activity
NBT05_10190	COG3119	arylsulfatase activity
NBT05_10200	COG3844	kynureninase activity
NBT05_10205	COG0336	Belongs to the RNA methyltransferase TrmD family
NBT05_10220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NBT05_10225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NBT05_10235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NBT05_10245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NBT05_10255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NBT05_10260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NBT05_10270	COG1739	Uncharacterized protein family UPF0029
NBT05_10275	COG2076	Multidrug Resistance protein
NBT05_10285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NBT05_10285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NBT05_10295	COG2890	protein-(glutamine-N5) methyltransferase activity
NBT05_10305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NBT05_10320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NBT05_10350	COG0497	DNA recombination
NBT05_10355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NBT05_10360	COG0463	Glycosyl transferase, family 2
NBT05_10370	COG0237	dephospho-CoA kinase activity
NBT05_10385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NBT05_10390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NBT05_10395	COG0322	excinuclease ABC activity
NBT05_10400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NBT05_10410	COG2813	Specifically methylates the guanine in position
NBT05_10420	COG3876	Protein conserved in bacteria
NBT05_10450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NBT05_10455	COG1115	amino acid carrier protein
NBT05_10465	COG1960	acyl-CoA dehydrogenase activity
NBT05_10470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NBT05_10475	COG4974	Belongs to the 'phage' integrase family
NBT05_10505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NBT05_10525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NBT05_10530	COG0081	regulation of translation
NBT05_10535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NBT05_10540	COG0222	ribosome binding
NBT05_10545	COG0085	RNA polymerase activity
NBT05_10550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NBT05_10560	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NBT05_10575	COG2885	chlorophyll binding
NBT05_10580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NBT05_10585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NBT05_10595	COG1073	alpha beta
NBT05_10625	COG3335	DDE superfamily endonuclease
NBT05_10635	COG0326	Molecular chaperone. Has ATPase activity
NBT05_10650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NBT05_10665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NBT05_10675	COG0488	(ABC) transporter
NBT05_10680	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NBT05_10695	COG1183	phosphatidylcholine synthase activity
NBT05_10700	COG1137	ATPase activity
NBT05_10710	COG0805	protein transport
NBT05_10715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NBT05_10715	COG0517	IMP dehydrogenase activity
NBT05_10720	COG0514	ATP-dependent DNA helicase (RecQ)
NBT05_10725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NBT05_10730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NBT05_10735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NBT05_10740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NBT05_10790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NBT05_10820	COG0681	Belongs to the peptidase S26 family
NBT05_10825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NBT05_10835	COG1475	DNA binding
NBT05_10840	COG1192	Involved in chromosome partitioning
NBT05_10845	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_10850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NBT05_10850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NBT05_10865	COG3401	FG-GAP repeat protein
NBT05_10870	COG3401	FG-GAP repeat protein
NBT05_10875	COG3401	FG-GAP repeat protein
NBT05_10880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NBT05_10895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NBT05_10915	COG0004	ammonium transporteR
NBT05_10925	COG0067	glutamate synthase
NBT05_10925	COG0069	glutamate synthase activity
NBT05_10925	COG0070	glutamate synthase
NBT05_10945	COG1917	Cupin 2, conserved barrel domain protein
NBT05_10945	COG4977	sequence-specific DNA binding
NBT05_10955	COG0450	alkyl hydroperoxide reductase
NBT05_10965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NBT05_10975	COG0592	DNA-directed DNA polymerase activity
NBT05_10995	COG1702	phosphate starvation-inducible protein PhoH
NBT05_11000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NBT05_11010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NBT05_11020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NBT05_11030	COG0083	homoserine kinase activity
NBT05_11035	COG0460	homoserine dehydrogenase
NBT05_11035	COG0527	aspartate kinase activity
NBT05_11040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NBT05_11065	COG2204	response regulator
NBT05_11070	COG1078	dGTPase activity
NBT05_11075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NBT05_11080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NBT05_11080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NBT05_11085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NBT05_11090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NBT05_11100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NBT05_11110	COG2226	methyltransferase
NBT05_11115	COG0116	Belongs to the methyltransferase superfamily
NBT05_11135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NBT05_11175	COG1169	isochorismate synthase
NBT05_11180	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NBT05_11190	COG2996	Protein conserved in bacteria
NBT05_11215	COG1611	Belongs to the LOG family
NBT05_11230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NBT05_11240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NBT05_11275	COG1104	cysteine desulfurase activity
NBT05_11305	COG1418	mRNA catabolic process
NBT05_11310	COG0542	response to heat
NBT05_11315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NBT05_11345	COG0784	Response regulator, receiver
NBT05_11345	COG2205	protein histidine kinase activity
NBT05_11350	COG0784	Response regulator, receiver
NBT05_11350	COG5002	protein histidine kinase activity
NBT05_11370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NBT05_11420	COG0537	adenosine 5'-monophosphoramidase activity
NBT05_11470	COG0583	DNA-binding transcription factor activity
NBT05_11490	COG1741	Belongs to the pirin family
NBT05_11500	COG1609	Transcriptional regulator
NBT05_11505	COG4771	TonB-dependent receptor
NBT05_11520	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NBT05_11535	COG1301	dicarboxylic acid transport
NBT05_11670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NBT05_11680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NBT05_11680	COG2207	Transcriptional regulator
NBT05_11710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NBT05_11745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NBT05_11760	COG0156	8-amino-7-oxononanoate synthase activity
NBT05_11805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NBT05_11815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NBT05_11820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NBT05_11865	COG0739	heme binding
NBT05_11890	COG1473	amidohydrolase
NBT05_11900	COG0384	phenazine biosynthesis protein PhzF
NBT05_11905	COG0604	alcohol dehydrogenase
NBT05_11910	COG0793	Belongs to the peptidase S41A family
NBT05_11950	COG1819	glycosyl
NBT05_11965	COG0270	DNA (cytosine-5-)-methyltransferase activity
NBT05_12030	COG1858	cytochrome C peroxidase
NBT05_12045	COG1136	(ABC) transporter
NBT05_12050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NBT05_12055	COG0302	gtp cyclohydrolase
NBT05_12080	COG3335	DDE superfamily endonuclease
NBT05_12095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NBT05_12100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NBT05_12110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NBT05_12120	COG4771	TonB-dependent receptor
NBT05_12125	COG0012	GTP binding
NBT05_12140	COG3011	Protein conserved in bacteria
NBT05_12150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NBT05_12170	COG0473	3-isopropylmalate dehydrogenase activity
NBT05_12180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NBT05_12190	COG0205	6-phosphofructokinase activity
NBT05_12195	COG1803	Methylglyoxal synthase
NBT05_12205	COG0450	alkyl hydroperoxide reductase
NBT05_12210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NBT05_12225	COG1674	ftsk spoiiie
NBT05_12240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NBT05_12240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NBT05_12265	COG1757	Na H antiporter
NBT05_12275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NBT05_12280	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NBT05_12290	COG1333	cytochrome c biogenesis protein
NBT05_12290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NBT05_12530	COG1609	Transcriptional regulator
NBT05_12550	COG2271	Major facilitator Superfamily
NBT05_12555	COG0673	inositol 2-dehydrogenase activity
NBT05_12570	COG0527	aspartate kinase activity
NBT05_12610	COG0606	chelatase, subunit chli
NBT05_12635	COG0009	L-threonylcarbamoyladenylate synthase
NBT05_12730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NBT05_12735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NBT05_12745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NBT05_12750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NBT05_12765	COG0784	Response regulator, receiver
NBT05_12765	COG5002	protein histidine kinase activity
NBT05_12925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NBT05_12940	COG0564	pseudouridine synthase activity
NBT05_12945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NBT05_12950	COG0443	Heat shock 70 kDa protein
NBT05_12960	COG0405	Gamma-glutamyltransferase
NBT05_12970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NBT05_12980	COG0705	Rhomboid family
NBT05_12985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NBT05_13010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NBT05_13015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NBT05_13020	COG1363	Peptidase, m42
NBT05_13075	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_13080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NBT05_13090	COG0488	(ABC) transporter
NBT05_13135	COG0280	phosphate acetyltransferase
NBT05_13135	COG0857	belongs to the CobB CobQ family
NBT05_13140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NBT05_13145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NBT05_13165	COG0069	glutamate synthase activity
NBT05_13170	COG1473	amidohydrolase
NBT05_13195	COG0129	dihydroxy-acid dehydratase activity
NBT05_13200	COG0028	Belongs to the TPP enzyme family
NBT05_13210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NBT05_13220	COG0137	argininosuccinate synthase activity
NBT05_13225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NBT05_13230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NBT05_13235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NBT05_13245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NBT05_13255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NBT05_13260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NBT05_13265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NBT05_13280	COG0165	Argininosuccinate lyase
NBT05_13285	COG0662	Cupin 2, conserved barrel domain protein
NBT05_13295	COG0561	phosphatase activity
NBT05_13320	COG3335	DDE superfamily endonuclease
NBT05_13325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NBT05_13330	COG0439	Biotin carboxylase
NBT05_13335	COG0511	ligase activity, forming carbon-carbon bonds
NBT05_13335	COG5016	pyruvate
NBT05_13350	COG2201	protein-glutamate methylesterase activity
NBT05_13360	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NBT05_13370	COG0612	Peptidase, M16
NBT05_13375	COG0612	Peptidase, M16
NBT05_13385	COG1607	acyl-coa hydrolase
NBT05_13410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NBT05_13420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NBT05_13450	COG1881	PFAM PEBP family protein
NBT05_13515	COG4106	trans-aconitate 2-methyltransferase activity
NBT05_13550	COG0861	Integral membrane protein TerC family
NBT05_13570	COG1522	sequence-specific DNA binding
NBT05_13575	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NBT05_13580	COG4680	protein conserved in bacteria
NBT05_13600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NBT05_13620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NBT05_13630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NBT05_13640	COG4974	Belongs to the 'phage' integrase family
NBT05_13690	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NBT05_13695	COG3387	PFAM Glycoside hydrolase 15-related
NBT05_13710	COG1131	(ABC) transporter
NBT05_13730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NBT05_13775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NBT05_13790	COG1132	(ABC) transporter
NBT05_13795	COG0513	Belongs to the DEAD box helicase family
NBT05_13825	COG0205	6-phosphofructokinase activity
NBT05_13855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NBT05_13855	COG2146	nitrite reductase [NAD(P)H] activity
NBT05_13860	COG2197	response regulator
NBT05_13875	COG0243	molybdopterin cofactor binding
NBT05_13880	COG1773	rubredoxin
NBT05_13885	COG1070	Carbohydrate kinase
NBT05_13890	COG2115	Belongs to the xylose isomerase family
NBT05_13915	COG3590	peptidase
NBT05_13940	COG0300	oxidoreductase activity
NBT05_13995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NBT05_14000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NBT05_14020	COG0217	transcriptional regulatory protein
NBT05_14025	COG2154	pterin-4-alpha-carbinolamine dehydratase
NBT05_14045	COG0424	maF-like protein
NBT05_14055	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NBT05_14065	COG1295	ribonuclease BN
NBT05_14085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NBT05_14090	COG3279	Response regulator of the LytR AlgR family
NBT05_14095	COG0360	Binds together with S18 to 16S ribosomal RNA
NBT05_14100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NBT05_14105	COG0359	binds to the 23S rRNA
NBT05_14110	COG3279	Response regulator of the LytR AlgR family
NBT05_14115	COG3275	phosphorelay sensor kinase activity
NBT05_14135	COG0124	histidyl-tRNA synthetase
NBT05_14155	COG0322	excinuclease ABC activity
NBT05_14160	COG0668	transmembrane transport
NBT05_14165	COG2267	carboxylic ester hydrolase activity
NBT05_14170	COG0346	lactoylglutathione lyase activity
NBT05_14195	COG3387	PFAM Glycoside hydrolase 15-related
NBT05_14200	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_14205	COG0415	Belongs to the DNA photolyase family
NBT05_14220	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_14230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NBT05_14245	COG0488	(ABC) transporter
NBT05_14255	COG1187	pseudouridine synthase activity
NBT05_14260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NBT05_14290	COG0297	glycogen (starch) synthase activity
NBT05_14295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NBT05_14300	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NBT05_14315	COG2270	Major facilitator Superfamily
NBT05_14325	COG2885	chlorophyll binding
NBT05_14330	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NBT05_14330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NBT05_14360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NBT05_14365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NBT05_14370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NBT05_14380	COG2814	Major facilitator Superfamily
NBT05_14405	COG1999	signal sequence binding
NBT05_14415	COG3279	Response regulator of the LytR AlgR family
NBT05_14435	COG0464	growth
NBT05_14455	COG1595	DNA-templated transcription, initiation
NBT05_14475	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NBT05_14485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NBT05_14490	COG1690	Belongs to the RtcB family
NBT05_14515	COG3541	Predicted nucleotidyltransferase
NBT05_14560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NBT05_14565	COG1193	negative regulation of DNA recombination
NBT05_14575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NBT05_14580	COG0673	inositol 2-dehydrogenase activity
NBT05_14605	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_14610	COG0415	Belongs to the DNA photolyase family
NBT05_14615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NBT05_14635	COG0514	ATP-dependent DNA helicase (RecQ)
NBT05_14640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NBT05_14650	COG1678	Uncharacterized ACR, COG1678
NBT05_14665	COG1116	anion transmembrane transporter activity
NBT05_14670	COG1116	anion transmembrane transporter activity
NBT05_14675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NBT05_14680	COG1116	anion transmembrane transporter activity
NBT05_14680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NBT05_14695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NBT05_14700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NBT05_14705	COG0277	FAD linked oxidase domain protein
NBT05_14705	COG0247	lactate metabolic process
NBT05_14730	COG0438	transferase activity, transferring glycosyl groups
NBT05_14740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NBT05_14770	COG4948	Mandelate Racemase Muconate Lactonizing
NBT05_14775	COG1575	Belongs to the MenA family. Type 1 subfamily
NBT05_14780	COG3344	reverse transcriptase
NBT05_14805	COG0183	Belongs to the thiolase family
NBT05_14810	COG0791	NLP P60 protein
NBT05_14815	COG1309	transcriptional regulator
NBT05_14820	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_14835	COG1045	serine acetyltransferase
NBT05_14850	COG2258	MOSC domain
NBT05_14860	COG2823	Periplasmic or secreted lipoprotein
NBT05_14860	COG1652	LysM domain
NBT05_14865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NBT05_14875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NBT05_14905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NBT05_14910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NBT05_14930	COG0110	maltose O-acetyltransferase activity
NBT05_14950	COG0438	transferase activity, transferring glycosyl groups
NBT05_14960	COG0438	transferase activity, transferring glycosyl groups
NBT05_14980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NBT05_14985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NBT05_15000	COG1696	Membrane protein involved in D-alanine export
NBT05_15005	COG0022	dehydrogenase e1 component
NBT05_15040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NBT05_15055	COG0259	pyridoxamine-phosphate oxidase activity
NBT05_15060	COG1234	tRNA 3'-trailer cleavage
NBT05_15070	COG0540	Belongs to the ATCase OTCase family
NBT05_15075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NBT05_15100	COG0539	negative regulation of cytoplasmic translation
NBT05_15105	COG4804	nuclease activity
NBT05_15135	COG0140	phosphoribosyl-ATP diphosphatase activity
NBT05_15135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NBT05_15140	COG0107	imidazoleglycerol-phosphate synthase activity
NBT05_15150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NBT05_15160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NBT05_15165	COG0131	Imidazoleglycerol-phosphate dehydratase
NBT05_15170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NBT05_15180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NBT05_15185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NBT05_15190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NBT05_15215	COG3119	arylsulfatase activity
NBT05_15220	COG1472	Belongs to the glycosyl hydrolase 3 family
NBT05_15230	COG2181	nitrate reductase activity
NBT05_15230	COG0247	lactate metabolic process
NBT05_15240	COG2181	nitrate reductase activity
NBT05_15240	COG0247	lactate metabolic process
NBT05_15245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NBT05_15250	COG0860	N-Acetylmuramoyl-L-alanine amidase
NBT05_15255	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NBT05_15260	COG0251	oxidation-reduction process
NBT05_15265	COG0626	cystathionine gamma-synthase activity
NBT05_15290	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_15295	COG0612	Peptidase, M16
NBT05_15310	COG1064	alcohol dehydrogenase
NBT05_15325	COG1741	Belongs to the pirin family
NBT05_15355	COG4447	cellulose binding
NBT05_15380	COG3047	cAMP biosynthetic process
NBT05_15415	COG3275	phosphorelay sensor kinase activity
NBT05_15430	COG0402	S-adenosylhomocysteine deaminase activity
NBT05_15435	COG3279	Response regulator of the LytR AlgR family
NBT05_15480	COG0714	Associated with various cellular activities
NBT05_15540	COG0492	ferredoxin-NADP+ reductase activity
NBT05_15545	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NBT05_15580	COG4251	negative regulation of phosphorylation
NBT05_15595	COG1309	transcriptional regulator
NBT05_15605	COG0673	inositol 2-dehydrogenase activity
NBT05_15610	COG0300	oxidoreductase activity
NBT05_15630	COG2885	chlorophyll binding
NBT05_15650	COG0604	alcohol dehydrogenase
NBT05_15750	COG0484	heat shock protein binding
NBT05_15755	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NBT05_15760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NBT05_15765	COG0572	uridine kinase
NBT05_15785	COG0105	UTP biosynthetic process
NBT05_15795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NBT05_15805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NBT05_15820	COG2195	Cleaves the N-terminal amino acid of tripeptides
NBT05_15850	COG0556	nucleotide-excision repair
NBT05_15855	COG0596	Alpha beta hydrolase
NBT05_15860	COG4251	negative regulation of phosphorylation
NBT05_15870	COG0673	inositol 2-dehydrogenase activity
NBT05_15885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NBT05_15890	COG0714	Associated with various cellular activities
NBT05_15895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NBT05_15905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NBT05_15920	COG0516	GMP reductase activity
NBT05_15920	COG0517	IMP dehydrogenase activity
NBT05_15955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NBT05_15980	COG0167	dihydroorotate dehydrogenase activity
NBT05_15985	COG2195	Cleaves the N-terminal amino acid of tripeptides
NBT05_15990	COG1862	Preprotein translocase
NBT05_16000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NBT05_16010	COG1132	(ABC) transporter
NBT05_16035	COG2318	DinB family
NBT05_16045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NBT05_16055	COG2205	protein histidine kinase activity
NBT05_16055	COG0784	Response regulator, receiver
NBT05_16065	COG0501	Belongs to the peptidase M48B family
NBT05_16070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NBT05_16075	COG0735	belongs to the Fur family
NBT05_16080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NBT05_16090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NBT05_16100	COG2852	Protein conserved in bacteria
NBT05_16115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NBT05_16130	COG0702	epimerase
NBT05_16135	COG4771	TonB-dependent receptor
NBT05_16140	COG3956	TIGRFAM MazG family protein
NBT05_16155	COG0482	sulfurtransferase activity
NBT05_16165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NBT05_16170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NBT05_16175	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NBT05_16180	COG0706	membrane insertase activity
NBT05_16185	COG0504	CTP synthase activity
NBT05_16195	COG0242	peptide deformylase activity
NBT05_16200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NBT05_16220	COG0859	PFAM glycosyl transferase family 9
NBT05_16230	COG0463	Glycosyl transferase, family 2
NBT05_16245	COG1215	transferase activity, transferring glycosyl groups
NBT05_16250	COG0009	L-threonylcarbamoyladenylate synthase
NBT05_16255	COG0517	IMP dehydrogenase activity
NBT05_16255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NBT05_16255	COG0617	tRNA 3'-terminal CCA addition
NBT05_16260	COG1612	heme a metabolic process
NBT05_16290	COG1022	Amp-dependent synthetase and ligase
NBT05_16300	COG1024	Enoyl-CoA hydratase
NBT05_16300	COG1250	3-hydroxyacyl-CoA dehydrogenase
NBT05_16310	COG0183	Belongs to the thiolase family
NBT05_16315	COG1960	acyl-CoA dehydrogenase activity
NBT05_16325	COG3279	Response regulator of the LytR AlgR family
NBT05_16330	COG3275	phosphorelay sensor kinase activity
NBT05_16340	COG0367	asparagine synthase
NBT05_16350	COG0602	queuosine metabolic process
NBT05_16355	COG0251	oxidation-reduction process
NBT05_16360	COG0433	COG0433 Predicted ATPase
NBT05_16365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NBT05_16365	COG0662	Cupin 2, conserved barrel domain protein
NBT05_16375	COG1187	pseudouridine synthase activity
NBT05_16400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NBT05_16425	COG3852	Histidine kinase
NBT05_16435	COG0492	ferredoxin-NADP+ reductase activity
NBT05_16450	COG0335	large ribosomal subunit rRNA binding
NBT05_16470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NBT05_16510	COG3328	transposase activity
NBT05_16515	COG3328	transposase activity
NBT05_16525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NBT05_16530	COG3022	response to hydroperoxide
NBT05_16535	COG1278	Cold shock
NBT05_16540	COG0564	pseudouridine synthase activity
NBT05_16545	COG2815	serine threonine protein kinase
NBT05_16545	COG0515	serine threonine protein kinase
NBT05_16550	COG1181	Belongs to the D-alanine--D-alanine ligase family
NBT05_16555	COG1280	lysine exporter protein (LysE YggA)
NBT05_16560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NBT05_16565	COG0659	secondary active sulfate transmembrane transporter activity
NBT05_16570	COG3275	phosphorelay sensor kinase activity
NBT05_16575	COG3279	Response regulator of the LytR AlgR family
NBT05_16615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NBT05_16630	COG0799	negative regulation of ribosome biogenesis
NBT05_16635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NBT05_16645	COG4589	Belongs to the CDS family
NBT05_16650	COG0688	phosphatidylethanolamine metabolic process
NBT05_16675	COG0525	valine-tRNA ligase activity
NBT05_16695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NBT05_16705	COG1595	DNA-templated transcription, initiation
NBT05_16740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NBT05_16745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NBT05_16750	COG0784	Response regulator, receiver
NBT05_16750	COG2205	protein histidine kinase activity
NBT05_16755	COG1663	tetraacyldisaccharide 4'-kinase activity
NBT05_16760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NBT05_16775	COG0268	Binds directly to 16S ribosomal RNA
NBT05_16790	COG0442	prolyl-tRNA aminoacylation
NBT05_16805	COG2207	Transcriptional regulator
NBT05_16805	COG1917	Cupin 2, conserved barrel domain protein
NBT05_16815	COG0302	gtp cyclohydrolase
NBT05_16820	COG0215	cysteine-tRNA ligase activity
NBT05_16825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NBT05_16830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NBT05_16840	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NBT05_16845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NBT05_16855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NBT05_16860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NBT05_16870	COG0174	glutamine synthetase
NBT05_16890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NBT05_16905	COG1309	transcriptional regulator
NBT05_16975	COG0596	Alpha beta hydrolase
NBT05_17000	COG3335	DDE superfamily endonuclease
NBT05_17005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NBT05_17055	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NBT05_17060	COG0076	glutamate decarboxylase activity
NBT05_17065	COG3279	Response regulator of the LytR AlgR family
NBT05_17070	COG3275	phosphorelay sensor kinase activity
NBT05_17085	COG3335	DDE superfamily endonuclease
NBT05_17095	COG3385	transposase activity
NBT05_17125	COG4974	Belongs to the 'phage' integrase family
NBT05_17155	COG0358	DNA primase activity
NBT05_17165	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NBT05_17195	COG4974	Belongs to the 'phage' integrase family
NBT05_17225	COG0358	DNA primase activity
NBT05_17235	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NBT05_17315	COG1459	type II secretion system
NBT05_17340	COG3279	Response regulator of the LytR AlgR family
NBT05_17345	COG2972	Histidine kinase
NBT05_17385	COG2273	Hydrolase Family 16
NBT05_17395	COG4771	TonB-dependent receptor
NBT05_17405	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
NBT05_17425	COG1131	(ABC) transporter
NBT05_17445	COG0438	transferase activity, transferring glycosyl groups
NBT05_17455	COG0312	modulator of DNA gyrase
NBT05_17465	COG0714	Associated with various cellular activities
NBT05_17495	COG0463	Glycosyl transferase, family 2
NBT05_17545	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NBT05_17580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NBT05_17600	COG0741	lytic transglycosylase activity
NBT05_17600	COG1388	LysM domain
NBT05_17620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NBT05_17625	COG0747	negative chemotaxis
NBT05_17640	COG0254	rRNA binding
NBT05_17650	COG0463	Glycosyl transferase, family 2
NBT05_17655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NBT05_17660	COG1132	(ABC) transporter
NBT05_17700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NBT05_17740	COG0793	Belongs to the peptidase S41A family
NBT05_17740	COG3409	Peptidoglycan-binding domain 1 protein
NBT05_17775	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
NBT05_17780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NBT05_17785	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NBT05_17800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NBT05_17805	COG1120	ATPase activity
NBT05_17825	COG1607	acyl-coa hydrolase
NBT05_17845	COG0071	Belongs to the small heat shock protein (HSP20) family
NBT05_17870	COG2706	6-phosphogluconolactonase activity
NBT05_17875	COG1404	Belongs to the peptidase S8 family
NBT05_17880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NBT05_17905	COG3340	Belongs to the peptidase S51 family
NBT05_17910	COG2066	Belongs to the glutaminase family
NBT05_17920	COG1054	Belongs to the UPF0176 family
NBT05_17940	COG0542	response to heat
NBT05_17945	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NBT05_17965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NBT05_17975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NBT05_17980	COG0673	inositol 2-dehydrogenase activity
NBT05_17985	COG1250	3-hydroxyacyl-CoA dehydrogenase
NBT05_18015	COG2884	Cell division ATP-binding protein ftsE
NBT05_18045	COG0438	transferase activity, transferring glycosyl groups
NBT05_18065	COG1217	gtp-binding protein TYPA
NBT05_18075	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NBT05_18100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NBT05_18125	COG0187	DNA topoisomerase II activity
NBT05_18185	COG0628	permease
NBT05_18215	COG0671	phosphoesterase, PA-phosphatase related
NBT05_18230	COG0534	Mate efflux family protein
NBT05_18250	COG1131	(ABC) transporter
NBT05_18265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NBT05_18275	COG2207	Transcriptional regulator
NBT05_18285	COG1028	Short-chain dehydrogenase reductase Sdr
NBT05_18295	COG0305	Participates in initiation and elongation during chromosome replication
NBT05_18300	COG0825	malonyl-CoA metabolic process
NBT05_18320	COG0343	queuine tRNA-ribosyltransferase activity