locus-tag	class	description
HN014_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HN014_00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HN014_00025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HN014_00035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HN014_00040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN014_00055	COG0336	Belongs to the RNA methyltransferase TrmD family
HN014_00060	COG0335	large ribosomal subunit rRNA binding
HN014_00070	COG1595	DNA-templated transcription, initiation
HN014_00110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HN014_00130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HN014_00135	COG0587	DNA-directed DNA polymerase activity
HN014_00140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HN014_00200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HN014_00205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HN014_00210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HN014_00215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HN014_00225	COG2205	protein histidine kinase activity
HN014_00225	COG0784	Response regulator, receiver
HN014_00230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN014_00245	COG0735	belongs to the Fur family
HN014_00250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HN014_00270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN014_00290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HN014_00310	COG4206	TonB-dependent receptor
HN014_00310	COG1629	transport
HN014_00315	COG2207	Transcriptional regulator
HN014_00315	COG4753	response regulator
HN014_00320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HN014_00340	COG3956	TIGRFAM MazG family protein
HN014_00350	COG0482	sulfurtransferase activity
HN014_00360	COG0706	membrane insertase activity
HN014_00365	COG0504	CTP synthase activity
HN014_00375	COG0242	peptide deformylase activity
HN014_00380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HN014_00415	COG0617	tRNA 3'-terminal CCA addition
HN014_00420	COG1612	heme a metabolic process
HN014_00445	COG1131	(ABC) transporter
HN014_00460	COG0556	nucleotide-excision repair
HN014_00495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HN014_00505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_00520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HN014_00525	COG0512	Glutamine amidotransferase of anthranilate synthase
HN014_00530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HN014_00535	COG0134	indole-3-glycerol-phosphate synthase activity
HN014_00540	COG0135	phosphoribosylanthranilate isomerase activity
HN014_00545	COG0133	tryptophan synthase activity
HN014_00550	COG0159	tryptophan synthase activity
HN014_00590	COG1696	Membrane protein involved in D-alanine export
HN014_00605	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HN014_00650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HN014_00660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HN014_00665	COG3022	response to hydroperoxide
HN014_00670	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HN014_00670	COG0778	Nitroreductase
HN014_00680	COG0564	pseudouridine synthase activity
HN014_00685	COG0515	serine threonine protein kinase
HN014_00685	COG2815	serine threonine protein kinase
HN014_00690	COG1181	Belongs to the D-alanine--D-alanine ligase family
HN014_00695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HN014_00715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HN014_00725	COG0659	secondary active sulfate transmembrane transporter activity
HN014_00735	COG0494	nUDIX hydrolase
HN014_00740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HN014_00755	COG0799	negative regulation of ribosome biogenesis
HN014_00760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HN014_00770	COG4589	Belongs to the CDS family
HN014_00775	COG0688	phosphatidylethanolamine metabolic process
HN014_00785	COG0525	valine-tRNA ligase activity
HN014_00800	COG0436	Aminotransferase
HN014_00805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HN014_00820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HN014_00825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HN014_00830	COG2205	protein histidine kinase activity
HN014_00830	COG3437	response regulator, receiver
HN014_00830	COG3850	Histidine kinase
HN014_00830	COG4999	Histidine kinase
HN014_00835	COG1663	tetraacyldisaccharide 4'-kinase activity
HN014_00840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HN014_00855	COG1846	Transcriptional regulator
HN014_00875	COG0268	Binds directly to 16S ribosomal RNA
HN014_00890	COG0442	prolyl-tRNA aminoacylation
HN014_00910	COG0302	gtp cyclohydrolase
HN014_00915	COG0215	cysteine-tRNA ligase activity
HN014_00920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HN014_00925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HN014_00930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HN014_00990	COG4796	Type ii and iii secretion system protein
HN014_00995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HN014_01005	COG4968	Prepilin-type N-terminal cleavage methylation domain
HN014_01060	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HN014_01070	COG1462	curli production assembly transport component CsgG
HN014_01110	COG3275	phosphorelay sensor kinase activity
HN014_01115	COG3279	Response regulator of the LytR AlgR family
HN014_01125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HN014_01185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN014_01235	COG1131	(ABC) transporter
HN014_01245	COG0215	cysteine-tRNA ligase activity
HN014_01250	COG4771	TonB-dependent receptor
HN014_01260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN014_01260	COG5549	protein import
HN014_01295	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_01300	COG4771	TonB-dependent receptor
HN014_01360	COG3275	phosphorelay sensor kinase activity
HN014_01365	COG3279	Response regulator of the LytR AlgR family
HN014_01405	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HN014_01440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_01445	COG3275	phosphorelay sensor kinase activity
HN014_01460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_01475	COG2226	methyltransferase
HN014_01520	COG0604	alcohol dehydrogenase
HN014_01520	COG3321	synthase
HN014_01525	COG0604	alcohol dehydrogenase
HN014_01525	COG3321	synthase
HN014_01565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN014_01615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HN014_01640	COG1335	isochorismatase
HN014_01645	COG2095	MarC family integral membrane protein
HN014_01655	COG0753	catalase activity
HN014_01675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HN014_01685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HN014_01695	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HN014_01710	COG0076	glutamate decarboxylase activity
HN014_01715	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HN014_01745	COG4771	TonB-dependent receptor
HN014_01765	COG2264	protein methyltransferase activity
HN014_01770	COG0149	triose-phosphate isomerase activity
HN014_01790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HN014_01815	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HN014_01820	COG3279	Response regulator of the LytR AlgR family
HN014_01825	COG2972	Histidine kinase
HN014_01830	COG4771	TonB-dependent receptor
HN014_01835	COG1132	(ABC) transporter
HN014_01870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HN014_01875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HN014_01880	COG0018	arginyl-trna synthetase
HN014_01885	COG1959	2 iron, 2 sulfur cluster binding
HN014_01895	COG0010	Belongs to the arginase family
HN014_01905	COG0148	phosphopyruvate hydratase activity
HN014_01910	COG0505	Belongs to the CarA family
HN014_01915	COG0203	ribosomal protein L17
HN014_01920	COG0202	RNA polymerase activity
HN014_01925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HN014_01930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HN014_01935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HN014_01940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HN014_01945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HN014_01955	COG0200	Binds to the 23S rRNA
HN014_01960	COG1841	ribosomal large subunit assembly
HN014_01965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HN014_01970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HN014_01975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HN014_01980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HN014_01985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HN014_01990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HN014_01995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HN014_02000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HN014_02005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HN014_02010	COG0255	Belongs to the universal ribosomal protein uL29 family
HN014_02015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HN014_02020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HN014_02025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HN014_02030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HN014_02035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HN014_02040	COG0089	rRNA binding
HN014_02045	COG0088	Forms part of the polypeptide exit tunnel
HN014_02050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HN014_02055	COG0051	transcription antitermination factor activity, RNA binding
HN014_02060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HN014_02065	COG0049	tRNA binding
HN014_02070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HN014_02075	COG4771	TonB-dependent receptor
HN014_02090	COG1629	transport
HN014_02090	COG4206	TonB-dependent receptor
HN014_02100	COG4771	TonB-dependent receptor
HN014_02110	COG1629	transport
HN014_02110	COG4206	TonB-dependent receptor
HN014_02120	COG4771	TonB-dependent receptor
HN014_02125	COG0702	epimerase
HN014_02130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN014_02140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HN014_02170	COG2003	Belongs to the UPF0758 family
HN014_02185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HN014_02190	COG2373	Large extracellular alpha-helical protein
HN014_02200	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_02205	COG2207	Transcriptional regulator
HN014_02215	COG1045	serine acetyltransferase
HN014_02225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HN014_02230	COG0563	adenylate kinase activity
HN014_02235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HN014_02240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HN014_02285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HN014_02285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HN014_02315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HN014_02320	COG1127	ABC transporter
HN014_02365	COG2234	aminopeptidase activity
HN014_02370	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_02375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HN014_02385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN014_02390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HN014_02400	COG3537	Alpha-1,2-mannosidase
HN014_02405	COG0702	epimerase
HN014_02410	COG1629	transport
HN014_02455	COG0848	biopolymer transport protein
HN014_02460	COG0811	peptide transport
HN014_02465	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HN014_02475	COG1960	acyl-CoA dehydrogenase activity
HN014_02540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HN014_02570	COG0321	lipoyl(octanoyl) transferase activity
HN014_02580	COG0401	homolog of Blt101
HN014_02585	COG2197	response regulator
HN014_02600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HN014_02605	COG0523	cobalamin synthesis protein
HN014_02630	COG4682	membrane
HN014_02645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HN014_02650	COG1705	Flagellar rod assembly protein muramidase FlgJ
HN014_02650	COG1388	LysM domain
HN014_02710	COG1595	DNA-templated transcription, initiation
HN014_02755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HN014_02805	COG0793	Belongs to the peptidase S41A family
HN014_02835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HN014_02840	COG1690	Belongs to the RtcB family
HN014_02850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_02895	COG0629	single-stranded DNA binding
HN014_02910	COG2249	NAD(P)H dehydrogenase (quinone) activity
HN014_02925	COG0546	phosphoglycolate phosphatase activity
HN014_02930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HN014_02940	COG0489	protein tyrosine kinase activity
HN014_02945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN014_02955	COG1696	Membrane protein involved in D-alanine export
HN014_02995	COG0438	transferase activity, transferring glycosyl groups
HN014_03035	COG0546	phosphoglycolate phosphatase activity
HN014_03040	COG0022	dehydrogenase e1 component
HN014_03045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HN014_03050	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_03070	COG1012	belongs to the aldehyde dehydrogenase family
HN014_03070	COG2030	dehydratase
HN014_03075	COG0183	Belongs to the thiolase family
HN014_03090	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_03095	COG1024	Enoyl-CoA hydratase
HN014_03100	COG2151	metal-sulfur cluster biosynthetic enzyme
HN014_03105	COG3396	Phenylacetate-CoA oxygenase
HN014_03110	COG3460	Phenylacetate-CoA oxygenase
HN014_03115	COG3396	Phenylacetate-CoA oxygenase
HN014_03120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HN014_03135	COG3186	Phenylalanine-4-hydroxylase
HN014_03150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HN014_03185	COG1160	GTP binding
HN014_03195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HN014_03200	COG0784	Response regulator, receiver
HN014_03210	COG4251	negative regulation of phosphorylation
HN014_03220	COG2205	protein histidine kinase activity
HN014_03230	COG3279	Response regulator of the LytR AlgR family
HN014_03275	COG0463	Glycosyl transferase, family 2
HN014_03280	COG1115	amino acid carrier protein
HN014_03350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN014_03360	COG2885	chlorophyll binding
HN014_03390	COG1629	transport
HN014_03390	COG4206	TonB-dependent receptor
HN014_03425	COG1858	cytochrome C peroxidase
HN014_03435	COG4771	TonB-dependent receptor
HN014_03460	COG3279	Response regulator of the LytR AlgR family
HN014_03465	COG2972	Histidine kinase
HN014_03475	COG2378	regulation of single-species biofilm formation
HN014_03485	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HN014_03500	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HN014_03505	COG4263	nitrous-oxide reductase activity
HN014_03530	COG1131	(ABC) transporter
HN014_03565	COG0315	cyclic pyranopterin monophosphate synthase activity
HN014_03580	COG0746	molybdenum cofactor guanylyltransferase activity
HN014_03590	COG2005	Transcriptional regulator
HN014_03595	COG0303	'Molybdopterin
HN014_03600	COG3005	denitrification pathway
HN014_03605	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HN014_03615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HN014_03640	COG0437	4 iron, 4 sulfur cluster binding
HN014_03665	COG4585	Histidine kinase
HN014_03670	COG4585	Histidine kinase
HN014_03890	COG3279	Response regulator of the LytR AlgR family
HN014_03895	COG0745	RESPONSE REGULATOR receiver
HN014_03895	COG2972	Histidine kinase
HN014_03950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HN014_03960	COG4968	Prepilin-type N-terminal cleavage methylation domain
HN014_04005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HN014_04015	COG3586	endonuclease activity
HN014_04385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN014_04480	COG1846	Transcriptional regulator
HN014_04625	COG0823	Involved in the tonB-independent uptake of proteins
HN014_04645	COG0488	(ABC) transporter
HN014_04675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN014_04685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HN014_04685	COG1754	DNA topoisomerase type I activity
HN014_04695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN014_04720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HN014_04725	COG0459	protein refolding
HN014_04750	COG2217	Heavy metal translocating P-type atpase
HN014_04765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN014_04780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HN014_04795	COG1253	flavin adenine dinucleotide binding
HN014_04820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HN014_04835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN014_04840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN014_04845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HN014_04850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN014_04860	COG1629	transport
HN014_04880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HN014_04905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HN014_04930	COG0662	Cupin 2, conserved barrel domain protein
HN014_04995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HN014_05015	COG1215	transferase activity, transferring glycosyl groups
HN014_05025	COG1187	pseudouridine synthase activity
HN014_05060	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HN014_05065	COG1309	transcriptional regulator
HN014_05080	COG2081	HI0933 family
HN014_05085	COG0584	glycerophosphoryl diester phosphodiesterase
HN014_05100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HN014_05105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HN014_05110	COG0228	four-way junction DNA binding
HN014_05155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HN014_05160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HN014_05180	COG2315	Protein conserved in bacteria
HN014_05185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HN014_05200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN014_05215	COG3938	Belongs to the proline racemase family
HN014_05220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN014_05225	COG0006	proline dipeptidase activity
HN014_05270	COG1999	signal sequence binding
HN014_05290	COG3279	Response regulator of the LytR AlgR family
HN014_05295	COG3275	phosphorelay sensor kinase activity
HN014_05300	COG4771	TonB-dependent receptor
HN014_05310	COG0363	glucosamine-6-phosphate deaminase activity
HN014_05315	COG1609	Transcriptional regulator
HN014_05320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HN014_05335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HN014_05350	COG0745	RESPONSE REGULATOR receiver
HN014_05370	COG1595	DNA-templated transcription, initiation
HN014_05380	COG1629	transport
HN014_05380	COG4206	TonB-dependent receptor
HN014_05415	COG4771	TonB-dependent receptor
HN014_05445	COG0513	Belongs to the DEAD box helicase family
HN014_05460	COG1629	transport
HN014_05460	COG4206	TonB-dependent receptor
HN014_05485	COG0589	response to stress
HN014_05495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HN014_05495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN014_05505	COG2217	Heavy metal translocating P-type atpase
HN014_05510	COG0259	pyridoxamine-phosphate oxidase activity
HN014_05520	COG3278	Belongs to the heme-copper respiratory oxidase family
HN014_05535	COG0348	domain, Protein
HN014_05560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HN014_05565	COG0589	response to stress
HN014_05570	COG0745	RESPONSE REGULATOR receiver
HN014_05575	COG5002	protein histidine kinase activity
HN014_05610	COG0489	protein tyrosine kinase activity
HN014_05625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HN014_05630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HN014_05635	COG5002	protein histidine kinase activity
HN014_05640	COG0745	RESPONSE REGULATOR receiver
HN014_05660	COG1629	transport
HN014_05670	COG0534	Mate efflux family protein
HN014_05700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HN014_05705	COG0702	epimerase
HN014_05715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN014_05720	COG0463	Glycosyl transferase, family 2
HN014_05735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HN014_05740	COG2363	Small membrane protein
HN014_05750	COG1522	sequence-specific DNA binding
HN014_05770	COG0495	leucyl-tRNA aminoacylation
HN014_05775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HN014_05780	COG2177	Part of the ABC transporter FtsEX involved in
HN014_05785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HN014_05800	COG1968	undecaprenyl-diphosphatase activity
HN014_05805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HN014_05825	COG0519	Catalyzes the synthesis of GMP from XMP
HN014_05830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HN014_05835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HN014_05845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HN014_05850	COG3852	Histidine kinase
HN014_05870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HN014_05880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HN014_05885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HN014_05890	COG2022	thiamine diphosphate biosynthetic process
HN014_05895	COG0352	thiamine-phosphate diphosphorylase activity
HN014_05900	COG0351	phosphomethylpyrimidine kinase
HN014_05910	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HN014_05925	COG0784	Response regulator, receiver
HN014_05925	COG2205	protein histidine kinase activity
HN014_05925	COG5002	protein histidine kinase activity
HN014_05930	COG2204	response regulator
HN014_05965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HN014_05975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HN014_05980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HN014_05990	COG0612	Peptidase, M16
HN014_06020	COG1194	a g-specific adenine glycosylase
HN014_06025	COG0776	regulation of translation
HN014_06030	COG1530	ribonuclease E activity
HN014_06105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HN014_06110	COG0596	Alpha beta hydrolase
HN014_06115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HN014_06125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HN014_06130	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HN014_06150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HN014_06170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HN014_06175	COG0463	Glycosyl transferase, family 2
HN014_06185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HN014_06195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HN014_06205	COG0297	glycogen (starch) synthase activity
HN014_06210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HN014_06215	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HN014_06230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HN014_06240	COG0667	Aldo Keto reductase
HN014_06255	COG4771	TonB-dependent receptor
HN014_06270	COG1360	Flagellar Motor Protein
HN014_06275	COG0708	Exodeoxyribonuclease III
HN014_06280	COG1137	ATPase activity
HN014_06300	COG0423	glycine-tRNA ligase activity
HN014_06310	COG1040	competence protein
HN014_06320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HN014_06325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HN014_06340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HN014_06345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HN014_06355	COG0189	ligase activity
HN014_06360	COG0189	ligase activity
HN014_06360	COG4067	protein conserved in archaea
HN014_06365	COG0322	excinuclease ABC activity
HN014_06370	COG1752	Esterase of the alpha-beta hydrolase superfamily
HN014_06375	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HN014_06380	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HN014_06400	COG0166	Belongs to the GPI family
HN014_06425	COG0481	GTPase activity
HN014_06440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HN014_06445	COG0346	lactoylglutathione lyase activity
HN014_06495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HN014_06505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HN014_06510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_06515	COG0511	ligase activity, forming carbon-carbon bonds
HN014_06520	COG0439	Biotin carboxylase
HN014_06545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HN014_06565	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HN014_06565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HN014_06590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HN014_06605	COG1435	thymidine kinase activity
HN014_06610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HN014_06615	COG1970	mechanosensitive ion channel activity
HN014_06620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HN014_06630	COG1505	serine-type exopeptidase activity
HN014_06635	COG3842	ATPase activity
HN014_06645	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN014_06655	COG0720	synthase
HN014_06660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HN014_06665	COG0534	Mate efflux family protein
HN014_06705	COG0210	DNA helicase
HN014_06740	COG0328	RNA-DNA hybrid ribonuclease activity
HN014_06740	COG3341	Caulimovirus viroplasmin
HN014_06750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN014_06755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HN014_06760	COG0571	ribonuclease III activity
HN014_06770	COG0469	pyruvate kinase activity
HN014_06785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HN014_06815	COG3279	Response regulator of the LytR AlgR family
HN014_06825	COG4447	cellulose binding
HN014_06830	COG0006	proline dipeptidase activity
HN014_06845	COG1114	Component of the transport system for branched-chain amino acids
HN014_06860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HN014_06885	COG1858	cytochrome C peroxidase
HN014_06890	COG0316	Belongs to the HesB IscA family
HN014_06895	COG0719	Fe-S assembly protein
HN014_06905	COG0396	ATPase activity
HN014_06910	COG0719	Fe-S assembly protein
HN014_06915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HN014_06935	COG2166	iron-sulfur cluster assembly
HN014_06940	COG2151	metal-sulfur cluster biosynthetic enzyme
HN014_06965	COG0454	-acetyltransferase
HN014_06975	COG0519	Catalyzes the synthesis of GMP from XMP
HN014_06980	COG1073	alpha beta
HN014_06985	COG0583	DNA-binding transcription factor activity
HN014_07005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN014_07020	COG0594	ribonuclease P activity
HN014_07025	COG0793	Belongs to the peptidase S41A family
HN014_07035	COG0698	ribose 5-phosphate isomerase
HN014_07050	COG0557	exoribonuclease II activity
HN014_07070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HN014_07075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN014_07085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN014_07090	COG3239	Fatty acid desaturase
HN014_07100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HN014_07105	COG0445	tRNA wobble uridine modification
HN014_07145	COG0657	acetylesterase activity
HN014_07160	COG0126	phosphoglycerate kinase activity
HN014_07165	COG0741	lytic transglycosylase activity
HN014_07165	COG1388	LysM domain
HN014_07180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HN014_07185	COG0739	heme binding
HN014_07205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HN014_07210	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HN014_07220	COG1091	dTDP-4-dehydrorhamnose reductase activity
HN014_07225	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HN014_07255	COG1215	transferase activity, transferring glycosyl groups
HN014_07260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN014_07265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HN014_07270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN014_07280	COG0151	Belongs to the GarS family
HN014_07300	COG0859	PFAM glycosyl transferase family 9
HN014_07340	COG0356	it plays a direct role in the translocation of protons across the membrane
HN014_07345	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN014_07350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HN014_07355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN014_07360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HN014_07365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HN014_07390	COG0756	dUTP diphosphatase activity
HN014_07420	COG0640	Transcriptional regulator
HN014_07425	COG1607	acyl-coa hydrolase
HN014_07445	COG1472	Belongs to the glycosyl hydrolase 3 family
HN014_07450	COG2897	thiosulfate sulfurtransferase activity
HN014_07460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HN014_07470	COG0662	Cupin 2, conserved barrel domain protein
HN014_07480	COG1012	belongs to the aldehyde dehydrogenase family
HN014_07510	COG4260	virion core protein, lumpy skin disease virus
HN014_07520	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HN014_07530	COG0754	glutathionylspermidine amidase activity
HN014_07535	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HN014_07550	COG4221	oxidoreductase activity
HN014_07555	COG0714	Associated with various cellular activities
HN014_07570	COG2304	oxidoreductase activity
HN014_07575	COG2304	oxidoreductase activity
HN014_07605	COG0288	reversible hydration of carbon dioxide
HN014_07610	COG0659	secondary active sulfate transmembrane transporter activity
HN014_07640	COG1595	DNA-templated transcription, initiation
HN014_07665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HN014_07690	COG2201	protein-glutamate methylesterase activity
HN014_07715	COG1595	DNA-templated transcription, initiation
HN014_07725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HN014_07735	COG1774	PSP1 C-terminal conserved region
HN014_07745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HN014_07750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HN014_07755	COG0450	alkyl hydroperoxide reductase
HN014_07765	COG4172	Belongs to the ABC transporter superfamily
HN014_07775	COG1024	Enoyl-CoA hydratase
HN014_07780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HN014_07785	COG0194	GDP metabolic process
HN014_07790	COG1561	YicC-like family, N-terminal region
HN014_07805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HN014_07820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HN014_07825	COG0181	hydroxymethylbilane synthase activity
HN014_07835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HN014_07840	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HN014_07845	COG0408	coproporphyrinogen oxidase activity
HN014_07885	COG1131	(ABC) transporter
HN014_07890	COG0113	porphobilinogen synthase activity
HN014_07895	COG4335	DNA alkylation repair
HN014_07925	COG1253	flavin adenine dinucleotide binding
HN014_08110	COG3023	N-Acetylmuramoyl-L-alanine amidase
HN014_08230	COG0626	cystathionine gamma-synthase activity
HN014_08240	COG1381	Involved in DNA repair and RecF pathway recombination
HN014_08245	COG4771	TonB-dependent receptor
HN014_08260	COG0346	lactoylglutathione lyase activity
HN014_08320	COG1418	mRNA catabolic process
HN014_08340	COG1446	asparaginase
HN014_08345	COG2373	Large extracellular alpha-helical protein
HN014_08355	COG4953	penicillin-binding protein 1C
HN014_08370	COG2954	triphosphatase activity
HN014_08375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HN014_08380	COG0436	Aminotransferase
HN014_08390	COG1053	succinate dehydrogenase
HN014_08395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HN014_08400	COG2234	aminopeptidase activity
HN014_08400	COG4935	Belongs to the peptidase S8 family
HN014_08425	COG0123	including yeast histone deacetylase and acetoin utilization protein
HN014_08430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN014_08430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN014_08455	COG1619	proteins homologs of microcin C7 resistance protein MccF
HN014_08460	COG0792	nuclease activity
HN014_08480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HN014_08490	COG0784	Response regulator, receiver
HN014_08490	COG2205	protein histidine kinase activity
HN014_08510	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HN014_08525	COG0527	aspartate kinase activity
HN014_08535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HN014_08570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN014_08575	COG0662	Cupin 2, conserved barrel domain protein
HN014_08580	COG2239	Acts as a magnesium transporter
HN014_08585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HN014_08600	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HN014_08605	COG0583	DNA-binding transcription factor activity
HN014_08625	COG0196	riboflavin kinase activity
HN014_08630	COG0193	aminoacyl-tRNA hydrolase activity
HN014_08635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HN014_08640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN014_08650	COG2226	methyltransferase
HN014_08650	COG3433	isochorismatase activity
HN014_08650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN014_08685	COG2226	methyltransferase
HN014_08685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN014_08685	COG3433	isochorismatase activity
HN014_08700	COG1131	(ABC) transporter
HN014_08710	COG1629	transport
HN014_08735	COG0668	transmembrane transport
HN014_08750	COG0793	Belongs to the peptidase S41A family
HN014_08765	COG2095	MarC family integral membrane protein
HN014_08780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HN014_08780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HN014_08785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HN014_08790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HN014_08815	COG1278	Cold shock
HN014_08830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HN014_08835	COG1629	transport
HN014_08835	COG4206	TonB-dependent receptor
HN014_08845	COG0517	IMP dehydrogenase activity
HN014_09010	COG1309	transcriptional regulator
HN014_09040	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_09060	COG3104	oligopeptide transport
HN014_09065	COG3104	oligopeptide transport
HN014_09080	COG2333	competence protein COMEC
HN014_09080	COG0658	competence protein
HN014_09085	COG0791	NLP P60 protein
HN014_09090	COG0784	Response regulator, receiver
HN014_09090	COG2205	protein histidine kinase activity
HN014_09100	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN014_09110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HN014_09120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN014_09135	COG0772	Belongs to the SEDS family
HN014_09140	COG0768	penicillin binding
HN014_09155	COG1077	Cell shape determining protein MreB Mrl
HN014_09160	COG0138	bifunctional purine biosynthesis protein purh
HN014_09190	COG0084	hydrolase, TatD family'
HN014_09195	COG0252	asparaginase activity
HN014_09205	COG0811	peptide transport
HN014_09255	COG4585	Histidine kinase
HN014_09285	COG0702	epimerase
HN014_09295	COG0702	epimerase
HN014_09300	COG4771	TonB-dependent receptor
HN014_09315	COG0295	cytidine deaminase activity
HN014_09340	COG2255	four-way junction helicase activity
HN014_09355	COG1842	Phage shock protein A
HN014_09365	COG1396	sequence-specific DNA binding
HN014_09375	COG0017	Asparaginyl-tRNA synthetase
HN014_09390	COG0233	cytoplasmic translational termination
HN014_09395	COG0528	UMP kinase activity
HN014_09400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HN014_09405	COG0052	Belongs to the universal ribosomal protein uS2 family
HN014_09410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HN014_09415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HN014_09425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN014_09425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN014_09460	COG0589	response to stress
HN014_09465	COG0779	Required for maturation of 30S ribosomal subunits
HN014_09470	COG0195	Participates in both transcription termination and antitermination
HN014_09475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HN014_09490	COG0437	4 iron, 4 sulfur cluster binding
HN014_09515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN014_09520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN014_09525	COG2255	four-way junction helicase activity
HN014_09530	COG2124	cytochrome p450
HN014_09535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HN014_09540	COG0280	phosphate acetyltransferase
HN014_09540	COG0281	malic enzyme
HN014_09545	COG0632	four-way junction helicase activity
HN014_09555	COG0509	glycine decarboxylation via glycine cleavage system
HN014_09575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN014_09580	COG0109	protoheme IX farnesyltransferase activity
HN014_09585	COG1845	cytochrome c oxidase, subunit III
HN014_09605	COG1999	signal sequence binding
HN014_09610	COG2322	membrane
HN014_09620	COG1136	(ABC) transporter
HN014_09625	COG0577	efflux transmembrane transporter activity
HN014_09625	COG1136	(ABC) transporter
HN014_09630	COG0577	efflux transmembrane transporter activity
HN014_09630	COG1136	(ABC) transporter
HN014_09635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN014_09645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN014_09650	COG1214	PFAM Peptidase M22, glycoprotease
HN014_09665	COG1331	Highly conserved protein containing a thioredoxin domain
HN014_09690	COG2972	Histidine kinase
HN014_09690	COG0745	RESPONSE REGULATOR receiver
HN014_09695	COG3279	Response regulator of the LytR AlgR family
HN014_09700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HN014_09720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HN014_09730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HN014_09740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HN014_09745	COG0596	Alpha beta hydrolase
HN014_09760	COG1950	PFAM Membrane protein of
HN014_09765	COG0544	peptidyl-prolyl cis-trans isomerase activity
HN014_09775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HN014_09830	COG0076	glutamate decarboxylase activity
HN014_09860	COG1428	Deoxynucleoside kinase
HN014_09865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN014_09870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HN014_09920	COG2161	toxin-antitoxin pair type II binding
HN014_09925	COG4115	mRNA cleavage
HN014_10035	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HN014_10070	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HN014_10075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HN014_10085	COG0022	dehydrogenase e1 component
HN014_10085	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_10090	COG2086	electron transfer activity
HN014_10095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HN014_10105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HN014_10110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HN014_10125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HN014_10135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HN014_10140	COG0402	S-adenosylhomocysteine deaminase activity
HN014_10145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HN014_10170	COG1428	Deoxynucleoside kinase
HN014_10210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HN014_10220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HN014_10225	COG0527	aspartate kinase activity
HN014_10225	COG0460	homoserine dehydrogenase
HN014_10230	COG1765	OsmC-like protein
HN014_10255	COG0175	sulfate reduction
HN014_10265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HN014_10270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HN014_10275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HN014_10275	COG1648	precorrin-2 dehydrogenase activity
HN014_10280	COG0492	ferredoxin-NADP+ reductase activity
HN014_10285	COG0633	Ferredoxin
HN014_10290	COG1410	methionine synthase
HN014_10290	COG0646	methionine synthase
HN014_10300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HN014_10315	COG1131	(ABC) transporter
HN014_10325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN014_10330	COG0156	8-amino-7-oxononanoate synthase activity
HN014_10335	COG1605	Chorismate mutase
HN014_10335	COG0077	Prephenate dehydratase
HN014_10340	COG0436	Aminotransferase
HN014_10345	COG0287	Prephenate dehydrogenase
HN014_10350	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HN014_10355	COG1162	GTPase activity
HN014_10360	COG1490	D-aminoacyl-tRNA deacylase activity
HN014_10380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HN014_10390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HN014_10420	COG0358	DNA primase activity
HN014_10430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HN014_10445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HN014_10450	COG2267	carboxylic ester hydrolase activity
HN014_10455	COG2001	Belongs to the MraZ family
HN014_10460	COG0275	rRNA processing
HN014_10470	COG0768	penicillin binding
HN014_10475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HN014_10480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HN014_10485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HN014_10490	COG0772	Belongs to the SEDS family
HN014_10495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HN014_10500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HN014_10515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HN014_10520	COG1610	YqeY-like protein
HN014_10600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN014_10935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN014_10950	COG4771	TonB-dependent receptor
HN014_10955	COG0702	epimerase
HN014_11025	COG3279	Response regulator of the LytR AlgR family
HN014_11030	COG3275	phosphorelay sensor kinase activity
HN014_11115	COG3971	2-oxopent-4-enoate hydratase activity
HN014_11160	COG0436	Aminotransferase
HN014_11165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HN014_11175	COG5441	Belongs to the UPF0261 family
HN014_11180	COG0531	amino acid
HN014_11190	COG1228	amidohydrolase
HN014_11195	COG4771	TonB-dependent receptor
HN014_11205	COG3292	Two component regulator propeller
HN014_11205	COG2205	protein histidine kinase activity
HN014_11205	COG0745	RESPONSE REGULATOR receiver
HN014_11215	COG4771	TonB-dependent receptor
HN014_11220	COG0702	epimerase
HN014_11250	COG0583	DNA-binding transcription factor activity
HN014_11275	COG1629	transport
HN014_11315	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_11320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_11325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_11345	COG4591	ABC-type transport system involved in lipoprotein release permease component
HN014_11350	COG1136	(ABC) transporter
HN014_11350	COG0577	efflux transmembrane transporter activity
HN014_11365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_11370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_11375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_11380	COG1073	alpha beta
HN014_11415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN014_11430	COG2211	Major facilitator Superfamily
HN014_11435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HN014_11460	COG0655	NAD(P)H dehydrogenase (quinone) activity
HN014_11495	COG1595	DNA-templated transcription, initiation
HN014_11515	COG4585	Histidine kinase
HN014_11540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HN014_11545	COG2224	Isocitrate lyase
HN014_11555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HN014_11560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HN014_11565	COG1185	polyribonucleotide nucleotidyltransferase activity
HN014_11570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HN014_11580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HN014_11585	COG0191	fructose-bisphosphate aldolase activity
HN014_11605	COG2226	methyltransferase
HN014_11610	COG0569	domain protein
HN014_11625	COG0436	Aminotransferase
HN014_11630	COG3239	Fatty acid desaturase
HN014_11635	COG0357	Ribosomal RNA small subunit methyltransferase G
HN014_11645	COG1012	belongs to the aldehyde dehydrogenase family
HN014_11660	COG2967	ApaG domain
HN014_11675	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HN014_11680	COG1805	sodium ion transport
HN014_11685	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HN014_11690	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HN014_11695	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HN014_11705	COG4585	Histidine kinase
HN014_11710	COG2197	response regulator
HN014_11725	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_11730	COG1309	transcriptional regulator
HN014_11750	COG1477	protein flavinylation
HN014_11755	COG2226	methyltransferase
HN014_11770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HN014_11775	COG0501	Belongs to the peptidase M48B family
HN014_11825	COG0463	Glycosyl transferase, family 2
HN014_11835	COG2066	Belongs to the glutaminase family
HN014_11840	COG3340	Belongs to the peptidase S51 family
HN014_11860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HN014_11865	COG1404	Belongs to the peptidase S8 family
HN014_11875	COG3844	kynureninase activity
HN014_11895	COG4977	sequence-specific DNA binding
HN014_11900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN014_11905	COG1012	belongs to the aldehyde dehydrogenase family
HN014_11940	COG0433	COG0433 Predicted ATPase
HN014_11945	COG0251	oxidation-reduction process
HN014_11950	COG0602	queuosine metabolic process
HN014_11960	COG0367	asparagine synthase
HN014_11970	COG0187	DNA topoisomerase II activity
HN014_11985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HN014_11995	COG4452	Inner membrane protein CreD
HN014_12030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HN014_12045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN014_12055	COG2884	Cell division ATP-binding protein ftsE
HN014_12070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HN014_12125	COG2197	response regulator
HN014_12130	COG4585	Histidine kinase
HN014_12135	COG3876	Protein conserved in bacteria
HN014_12165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HN014_12170	COG1115	amino acid carrier protein
HN014_12180	COG1960	acyl-CoA dehydrogenase activity
HN014_12185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HN014_12190	COG4974	Belongs to the 'phage' integrase family
HN014_12240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HN014_12245	COG0081	regulation of translation
HN014_12250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HN014_12255	COG0222	ribosome binding
HN014_12260	COG0085	RNA polymerase activity
HN014_12265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HN014_12280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HN014_12295	COG2885	chlorophyll binding
HN014_12300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HN014_12310	COG1482	cell wall glycoprotein biosynthetic process
HN014_12340	COG0561	phosphatase activity
HN014_12370	COG0326	Molecular chaperone. Has ATPase activity
HN014_12375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_12390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN014_12395	COG1136	(ABC) transporter
HN014_12440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HN014_12445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HN014_12455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HN014_12470	COG0612	Peptidase, M16
HN014_12475	COG0339	signal peptide processing
HN014_12485	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HN014_12505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HN014_12505	COG0519	Catalyzes the synthesis of GMP from XMP
HN014_12510	COG1388	LysM domain
HN014_12510	COG3942	CHAP domain
HN014_12520	COG3530	Putative quorum-sensing-regulated virulence factor
HN014_12525	COG0019	diaminopimelate decarboxylase activity
HN014_12530	COG0045	succinate-CoA ligase (ADP-forming) activity
HN014_12555	COG0071	Belongs to the small heat shock protein (HSP20) family
HN014_12560	COG2201	protein-glutamate methylesterase activity
HN014_12565	COG0784	Response regulator, receiver
HN014_12565	COG2205	protein histidine kinase activity
HN014_12600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN014_12670	COG0300	oxidoreductase activity
HN014_12730	COG0840	transmembrane signaling receptor activity
HN014_12750	COG0488	(ABC) transporter
HN014_12755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HN014_12760	COG1183	phosphatidylcholine synthase activity
HN014_12765	COG1137	ATPase activity
HN014_12770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HN014_12775	COG0805	protein transport
HN014_12780	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HN014_12780	COG0517	IMP dehydrogenase activity
HN014_12785	COG0514	ATP-dependent DNA helicase (RecQ)
HN014_12790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HN014_12810	COG1132	(ABC) transporter
HN014_12820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN014_12830	COG1862	Preprotein translocase
HN014_12835	COG0668	transmembrane transport
HN014_12840	COG2195	Cleaves the N-terminal amino acid of tripeptides
HN014_12860	COG0789	Transcriptional regulator
HN014_12870	COG0167	dihydroorotate dehydrogenase activity
HN014_12910	COG1840	ABC-type Fe3 transport system, periplasmic component
HN014_12920	COG3842	ATPase activity
HN014_12925	COG1528	Iron-storage protein
HN014_12930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_12950	COG0517	IMP dehydrogenase activity
HN014_12950	COG0516	GMP reductase activity
HN014_12955	COG4977	sequence-specific DNA binding
HN014_12955	COG1917	Cupin 2, conserved barrel domain protein
HN014_12970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN014_12980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN014_12985	COG0714	Associated with various cellular activities
HN014_13005	COG2885	chlorophyll binding
HN014_13010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HN014_13015	COG1056	cytidyltransferase-related domain
HN014_13015	COG1051	belongs to the nudix hydrolase family
HN014_13020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN014_13025	COG1397	ADP-ribosylglycohydrolase
HN014_13030	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HN014_13090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_13110	COG3275	phosphorelay sensor kinase activity
HN014_13115	COG3279	Response regulator of the LytR AlgR family
HN014_13180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN014_13215	COG0778	Nitroreductase
HN014_13220	COG1733	regulation of RNA biosynthetic process
HN014_13245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_13325	COG2207	Transcriptional regulator
HN014_13325	COG1609	Transcriptional regulator
HN014_13380	COG3279	Response regulator of the LytR AlgR family
HN014_13395	COG0284	orotidine-5'-phosphate decarboxylase activity
HN014_13400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HN014_13425	COG0788	formyltetrahydrofolate deformylase activity
HN014_13430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_13430	COG1703	isobutyryl-CoA mutase activity
HN014_13430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_13440	COG2972	Histidine kinase
HN014_13445	COG2204	response regulator
HN014_13455	COG1522	sequence-specific DNA binding
HN014_13465	COG1115	amino acid carrier protein
HN014_13470	COG2311	Membrane
HN014_13475	COG1595	DNA-templated transcription, initiation
HN014_13490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HN014_13525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HN014_13535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN014_13535	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HN014_13540	COG1090	epimerase
HN014_13550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HN014_13555	COG0484	heat shock protein binding
HN014_13560	COG4152	abc transporter atp-binding protein
HN014_13570	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HN014_13570	COG3264	Mechanosensitive ion channel
HN014_13590	COG2326	polyphosphate kinase activity
HN014_13600	COG3781	membrane
HN014_13605	COG1506	peptidase
HN014_13610	COG1629	transport
HN014_13640	COG1595	DNA-templated transcription, initiation
HN014_13655	COG4771	TonB-dependent receptor
HN014_13685	COG0534	Mate efflux family protein
HN014_13695	COG0671	phosphoesterase, PA-phosphatase related
HN014_13705	COG0010	Belongs to the arginase family
HN014_13720	COG1703	isobutyryl-CoA mutase activity
HN014_13725	COG1764	response to oxidative stress
HN014_13770	COG0716	FMN binding
HN014_13785	COG1595	DNA-templated transcription, initiation
HN014_13795	COG0653	protein targeting
HN014_13815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HN014_13820	COG1216	Glycosyl transferase, family 2
HN014_13825	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_13830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN014_13835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN014_13840	COG1121	(ABC) transporter
HN014_13845	COG0803	Belongs to the bacterial solute-binding protein 9 family
HN014_13850	COG1321	iron dependent repressor
HN014_13850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN014_13860	COG0179	Fumarylacetoacetate (FAA) hydrolase
HN014_13870	COG1546	Belongs to the CinA family
HN014_13870	COG1058	Belongs to the CinA family
HN014_13875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HN014_13880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HN014_13890	COG0552	protein localization to endoplasmic reticulum
HN014_13895	COG0154	amidase activity
HN014_13900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN014_13920	COG3958	Transketolase
HN014_13930	COG0343	queuine tRNA-ribosyltransferase activity
HN014_13945	COG0825	malonyl-CoA metabolic process
HN014_13950	COG0305	Participates in initiation and elongation during chromosome replication
HN014_13970	COG1228	amidohydrolase
HN014_13985	COG2195	Cleaves the N-terminal amino acid of tripeptides
HN014_14000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HN014_14010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HN014_14015	COG0105	UTP biosynthetic process
HN014_14045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HN014_14055	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HN014_14065	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HN014_14095	COG0681	Belongs to the peptidase S26 family
HN014_14100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HN014_14110	COG1475	DNA binding
HN014_14115	COG1192	Involved in chromosome partitioning
HN014_14120	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_14125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_14125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_14135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_14135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_14145	COG0572	uridine kinase
HN014_14185	COG4232	protein-disulfide reductase activity
HN014_14190	COG4771	TonB-dependent receptor
HN014_14195	COG1271	oxidase subunit
HN014_14255	COG4771	TonB-dependent receptor
HN014_14270	COG2207	Transcriptional regulator
HN014_14275	COG2860	membrane
HN014_14360	COG3152	Membrane
HN014_14440	COG0714	Associated with various cellular activities
HN014_14490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN014_14505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HN014_14540	COG2819	hydrolase of the alpha beta superfamily
HN014_14590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_14605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN014_14610	COG1741	Belongs to the pirin family
HN014_14625	COG0436	Aminotransferase
HN014_14630	COG2423	ornithine cyclodeaminase activity
HN014_14645	COG4977	sequence-specific DNA binding
HN014_14650	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HN014_14680	COG0519	Catalyzes the synthesis of GMP from XMP
HN014_14695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_14715	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_14780	COG3275	phosphorelay sensor kinase activity
HN014_14785	COG4555	ABC transporter
HN014_14800	COG1473	amidohydrolase
HN014_14840	COG0523	cobalamin synthesis protein
HN014_14845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HN014_14870	COG0456	acetyltransferase
HN014_14890	COG2382	esterase
HN014_14905	COG1280	lysine exporter protein (LysE YggA)
HN014_14920	COG1131	(ABC) transporter
HN014_14925	COG3655	Transcriptional regulator
HN014_15085	COG0024	Methionine aminopeptidase
HN014_15100	COG0596	Alpha beta hydrolase
HN014_15195	COG4941	Belongs to the sigma-70 factor family
HN014_15235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_15290	COG1231	oxidoreductase activity
HN014_15310	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_15335	COG4974	Belongs to the 'phage' integrase family
HN014_15365	COG5002	protein histidine kinase activity
HN014_15365	COG2198	Histidine kinase
HN014_15365	COG0784	Response regulator, receiver
HN014_15415	COG1629	transport
HN014_15415	COG4206	TonB-dependent receptor
HN014_15435	COG1960	acyl-CoA dehydrogenase activity
HN014_15440	COG0183	Belongs to the thiolase family
HN014_15445	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_15445	COG1024	Enoyl-CoA hydratase
HN014_15450	COG1846	Transcriptional regulator
HN014_15455	COG1022	Amp-dependent synthetase and ligase
HN014_15475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN014_15475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HN014_15495	COG1595	DNA-templated transcription, initiation
HN014_15500	COG1132	(ABC) transporter
HN014_15505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HN014_15510	COG0463	Glycosyl transferase, family 2
HN014_15520	COG0254	rRNA binding
HN014_15530	COG0747	negative chemotaxis
HN014_15535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN014_15565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HN014_15570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HN014_15605	COG1120	ATPase activity
HN014_15610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HN014_15625	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HN014_15635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HN014_15640	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HN014_15660	COG1595	DNA-templated transcription, initiation
HN014_15690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HN014_15725	COG2885	chlorophyll binding
HN014_15740	COG0513	Belongs to the DEAD box helicase family
HN014_15755	COG0300	oxidoreductase activity
HN014_15760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HN014_15770	COG0488	(ABC) transporter
HN014_15800	COG0280	phosphate acetyltransferase
HN014_15800	COG0857	belongs to the CobB CobQ family
HN014_15805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HN014_15865	COG2356	endonuclease I
HN014_15870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HN014_15895	COG0069	glutamate synthase activity
HN014_15900	COG1473	amidohydrolase
HN014_15925	COG0009	L-threonylcarbamoyladenylate synthase
HN014_15955	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_15960	COG0626	cystathionine gamma-synthase activity
HN014_15965	COG1522	sequence-specific DNA binding
HN014_15995	COG1393	Belongs to the ArsC family
HN014_16015	COG3422	double-strand break repair
HN014_16020	COG2885	chlorophyll binding
HN014_16025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HN014_16040	COG0156	8-amino-7-oxononanoate synthase activity
HN014_16115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HN014_16130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HN014_16135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HN014_16205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN014_16230	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HN014_16235	COG3142	Participates in the control of copper homeostasis
HN014_16265	COG1136	(ABC) transporter
HN014_16275	COG0302	gtp cyclohydrolase
HN014_16300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN014_16305	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HN014_16315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HN014_16325	COG4771	TonB-dependent receptor
HN014_16330	COG0012	GTP binding
HN014_16340	COG5002	protein histidine kinase activity
HN014_16340	COG2198	Histidine kinase
HN014_16340	COG0784	Response regulator, receiver
HN014_16390	COG0697	spore germination
HN014_16400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HN014_16400	COG1017	nitric oxide dioxygenase activity
HN014_16410	COG3279	Response regulator of the LytR AlgR family
HN014_16415	COG3275	phosphorelay sensor kinase activity
HN014_16480	COG0668	transmembrane transport
HN014_16495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HN014_16500	COG0861	Integral membrane protein TerC family
HN014_16520	COG1522	sequence-specific DNA binding
HN014_16525	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HN014_16620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HN014_16625	COG0583	DNA-binding transcription factor activity
HN014_16640	COG1169	isochorismate synthase
HN014_16645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HN014_16655	COG2996	Protein conserved in bacteria
HN014_16695	COG1611	Belongs to the LOG family
HN014_16700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HN014_16725	COG0471	metal ion transport
HN014_16735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HN014_16755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HN014_16790	COG2204	response regulator
HN014_16795	COG1078	dGTPase activity
HN014_16800	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN014_16805	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HN014_16805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN014_16810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN014_16815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HN014_16825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HN014_16830	COG0612	Peptidase, M16
HN014_16835	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_16855	COG2885	chlorophyll binding
HN014_16860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HN014_16865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HN014_16870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HN014_16875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HN014_16875	COG0131	Imidazoleglycerol-phosphate dehydratase
HN014_16885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HN014_16890	COG0107	imidazoleglycerol-phosphate synthase activity
HN014_16895	COG0140	phosphoribosyl-ATP diphosphatase activity
HN014_16895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HN014_16915	COG0539	negative regulation of cytoplasmic translation
HN014_16920	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HN014_16925	COG0540	Belongs to the ATCase OTCase family
HN014_16935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_16940	COG1234	tRNA 3'-trailer cleavage
HN014_16945	COG0259	pyridoxamine-phosphate oxidase activity
HN014_16960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HN014_17025	COG3279	Response regulator of the LytR AlgR family
HN014_17030	COG0438	transferase activity, transferring glycosyl groups
HN014_17055	COG0277	FAD linked oxidase domain protein
HN014_17055	COG0247	lactate metabolic process
HN014_17070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HN014_17075	COG1301	dicarboxylic acid transport
HN014_17085	COG3011	Protein conserved in bacteria
HN014_17095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HN014_17110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HN014_17115	COG0083	homoserine kinase activity
HN014_17120	COG0460	homoserine dehydrogenase
HN014_17120	COG0527	aspartate kinase activity
HN014_17130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HN014_17140	COG4974	Belongs to the 'phage' integrase family
HN014_17155	COG1404	Belongs to the peptidase S8 family
HN014_17160	COG1404	Belongs to the peptidase S8 family
HN014_17165	COG1404	Belongs to the peptidase S8 family
HN014_17175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HN014_17180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN014_17220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HN014_17225	COG1360	Flagellar Motor Protein
HN014_17255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HN014_17265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_17270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HN014_17280	COG1187	pseudouridine synthase activity
HN014_17295	COG0640	Transcriptional regulator
HN014_17305	COG1280	lysine exporter protein (LysE YggA)
HN014_17315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HN014_17375	COG3279	Response regulator of the LytR AlgR family
HN014_17395	COG1131	(ABC) transporter
HN014_17400	COG2972	Histidine kinase
HN014_17405	COG3279	Response regulator of the LytR AlgR family
HN014_17435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HN014_17455	COG0583	DNA-binding transcription factor activity
HN014_17460	COG2079	MmgE PrpD family protein
HN014_17475	COG2204	response regulator
HN014_17485	COG1136	(ABC) transporter
HN014_17495	COG0577	efflux transmembrane transporter activity
HN014_17555	COG2972	Histidine kinase
HN014_17585	COG3279	Response regulator of the LytR AlgR family
HN014_17595	COG3537	Alpha-1,2-mannosidase
HN014_17605	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HN014_17620	COG3537	Alpha-1,2-mannosidase
HN014_17625	COG1446	asparaginase
HN014_17630	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HN014_17675	COG1629	transport
HN014_17710	COG0596	Alpha beta hydrolase
HN014_17725	COG4946	Tricorn protease homolog
HN014_17725	COG1506	peptidase
HN014_17725	COG0823	Involved in the tonB-independent uptake of proteins
HN014_17765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HN014_17780	COG4221	oxidoreductase activity
HN014_17815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HN014_17825	COG0640	Transcriptional regulator
HN014_17830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HN014_17830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN014_17835	COG2814	Major facilitator Superfamily
HN014_17840	COG1104	cysteine desulfurase activity
HN014_17850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN014_17855	COG2274	protein secretion by the type I secretion system
HN014_17875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN014_17875	COG0784	Response regulator, receiver
HN014_17875	COG2205	protein histidine kinase activity
HN014_17875	COG2198	Histidine kinase
HN014_17895	COG3047	cAMP biosynthetic process
HN014_17900	COG4733	cellulase activity
HN014_17900	COG5297	Belongs to the glycosyl hydrolase family 6
HN014_17920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_17930	COG1846	Transcriptional regulator
HN014_18000	COG3279	Response regulator of the LytR AlgR family
HN014_18015	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HN014_18030	COG4628	conserved protein (DUF2132)
HN014_18050	COG3279	Response regulator of the LytR AlgR family
HN014_18055	COG2972	Histidine kinase
HN014_18090	COG4821	SIS domain
HN014_18160	COG0730	response to heat
HN014_18165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HN014_18175	COG1522	sequence-specific DNA binding
HN014_18215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN014_18220	COG2885	chlorophyll binding
HN014_18235	COG2270	Major facilitator Superfamily
HN014_18275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HN014_18280	COG0076	glutamate decarboxylase activity
HN014_18295	COG0488	(ABC) transporter
HN014_18305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HN014_18315	COG2304	oxidoreductase activity
HN014_18420	COG2072	flavoprotein involved in K transport
HN014_18425	COG1595	DNA-templated transcription, initiation
HN014_18470	COG3011	Protein conserved in bacteria
HN014_18485	COG4948	Mandelate Racemase Muconate Lactonizing
HN014_18490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HN014_18495	COG1575	Belongs to the MenA family. Type 1 subfamily
HN014_18515	COG0668	transmembrane transport
HN014_18525	COG1480	7TM receptor with intracellular HD hydrolase
HN014_18530	COG0183	Belongs to the thiolase family
HN014_18535	COG0791	NLP P60 protein
HN014_18545	COG1609	Transcriptional regulator
HN014_18560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HN014_18570	COG1045	serine acetyltransferase
HN014_18580	COG0514	ATP-dependent DNA helicase (RecQ)
HN014_18595	COG2823	Periplasmic or secreted lipoprotein
HN014_18595	COG1652	LysM domain
HN014_18615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HN014_18620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HN014_18665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HN014_18670	COG1696	Membrane protein involved in D-alanine export
HN014_18680	COG0110	maltose O-acetyltransferase activity
HN014_18685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN014_18705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HN014_18710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN014_18725	COG0438	transferase activity, transferring glycosyl groups
HN014_18730	COG5434	Belongs to the glycosyl hydrolase 28 family
HN014_18735	COG0367	asparagine synthase
HN014_18740	COG1216	Glycosyl transferase, family 2
HN014_18740	COG1442	glycosyl transferase family 8
HN014_18755	COG0438	transferase activity, transferring glycosyl groups
HN014_18775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HN014_18780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN014_18785	COG0022	dehydrogenase e1 component
HN014_18825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HN014_18830	COG1193	negative regulation of DNA recombination
HN014_18835	COG1404	Belongs to the peptidase S8 family
HN014_18835	COG4935	Belongs to the peptidase S8 family
HN014_18840	COG1573	uracil-dna glycosylase
HN014_18860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN014_18865	COG0673	inositol 2-dehydrogenase activity
HN014_18875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HN014_18890	COG0415	Belongs to the DNA photolyase family
HN014_18895	COG0583	DNA-binding transcription factor activity
HN014_18900	COG2986	histidine ammonia-lyase
HN014_18910	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HN014_18915	COG0010	Belongs to the arginase family
HN014_18940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HN014_18960	COG0514	ATP-dependent DNA helicase (RecQ)
HN014_18965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HN014_18975	COG1678	Uncharacterized ACR, COG1678
HN014_18980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HN014_19005	COG3292	Two component regulator propeller
HN014_19005	COG0745	RESPONSE REGULATOR receiver
HN014_19005	COG2205	protein histidine kinase activity
HN014_19050	COG2311	Membrane
HN014_19065	COG2205	protein histidine kinase activity
HN014_19070	COG3279	Response regulator of the LytR AlgR family
HN014_19090	COG0076	glutamate decarboxylase activity
HN014_19125	COG3279	Response regulator of the LytR AlgR family
HN014_19130	COG3275	phosphorelay sensor kinase activity
HN014_19135	COG3275	phosphorelay sensor kinase activity
HN014_19145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN014_19190	COG0662	Cupin 2, conserved barrel domain protein
HN014_19190	COG2207	Transcriptional regulator
HN014_19200	COG4585	Histidine kinase
HN014_19210	COG0124	histidyl-tRNA synthetase
HN014_19215	COG0577	efflux transmembrane transporter activity
HN014_19230	COG0359	binds to the 23S rRNA
HN014_19235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HN014_19240	COG0360	Binds together with S18 to 16S ribosomal RNA
HN014_19245	COG3279	Response regulator of the LytR AlgR family
HN014_19250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HN014_19275	COG1295	ribonuclease BN
HN014_19285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HN014_19295	COG0424	maF-like protein
HN014_19305	COG2154	pterin-4-alpha-carbinolamine dehydratase
HN014_19310	COG0217	transcriptional regulatory protein
HN014_19325	COG1012	belongs to the aldehyde dehydrogenase family
HN014_19340	COG0318	PFAM AMP-dependent synthetase and ligase
HN014_19345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN014_19370	COG1454	alcohol dehydrogenase
HN014_19380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN014_19420	COG1472	Belongs to the glycosyl hydrolase 3 family
HN014_19430	COG2181	nitrate reductase activity
HN014_19430	COG0247	lactate metabolic process
HN014_19440	COG0247	lactate metabolic process
HN014_19440	COG2181	nitrate reductase activity
HN014_19445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HN014_19450	COG0860	N-Acetylmuramoyl-L-alanine amidase
HN014_19460	COG0251	oxidation-reduction process
HN014_19470	COG0753	catalase activity
HN014_19485	COG3256	nitric oxide reductase
HN014_19490	COG0205	6-phosphofructokinase activity
HN014_19500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HN014_19510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HN014_19535	COG0628	permease
HN014_19590	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HN014_19600	COG1473	amidohydrolase
HN014_19615	COG0723	plastoquinol--plastocyanin reductase activity
HN014_19615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN014_19630	COG0302	gtp cyclohydrolase
HN014_19635	COG1136	(ABC) transporter
HN014_19655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HN014_19720	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HN014_19735	COG0386	Belongs to the glutathione peroxidase family
HN014_19790	COG0688	phosphatidylethanolamine metabolic process
HN014_19815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HN014_19820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HN014_19830	COG0826	peptidase U32
HN014_19850	COG1492	cobalamin metabolic process
HN014_19885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN014_19890	COG1648	precorrin-2 dehydrogenase activity
HN014_19890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HN014_19905	COG1797	cobyrinic acid a,c-diamide synthase activity
HN014_19910	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HN014_20005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HN014_20020	COG1191	sigma factor activity
HN014_20040	COG1233	COG1233 Phytoene dehydrogenase and related
HN014_20075	COG3275	phosphorelay sensor kinase activity
HN014_20090	COG3279	Response regulator of the LytR AlgR family
HN014_20115	COG1733	regulation of RNA biosynthetic process
HN014_20125	COG3279	Response regulator of the LytR AlgR family
HN014_20150	COG1522	sequence-specific DNA binding
HN014_20160	COG1280	lysine exporter protein (LysE YggA)
HN014_20195	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HN014_20220	COG0778	Nitroreductase
HN014_20235	COG2096	Adenosyltransferase
HN014_20250	COG2949	membrane
HN014_20255	COG1333	cytochrome c biogenesis protein
HN014_20255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HN014_20270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HN014_20285	COG1607	acyl-coa hydrolase
HN014_20290	COG0778	Nitroreductase
HN014_20295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_20300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HN014_20305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN014_20305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN014_20320	COG1674	ftsk spoiiie
HN014_20325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HN014_20345	COG0450	alkyl hydroperoxide reductase
HN014_20350	COG0784	Response regulator, receiver
HN014_20350	COG2205	protein histidine kinase activity
HN014_20355	COG0626	cystathionine gamma-synthase activity
HN014_20360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HN014_20375	COG2234	aminopeptidase activity
HN014_20420	COG0791	NLP P60 protein
HN014_20440	COG0784	Response regulator, receiver
HN014_20440	COG2205	protein histidine kinase activity
HN014_20445	COG2205	protein histidine kinase activity
HN014_20445	COG0784	Response regulator, receiver
HN014_20460	COG0542	response to heat
HN014_20495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HN014_20500	COG0542	response to heat
HN014_20510	COG1418	mRNA catabolic process
HN014_20530	COG0562	UDP-galactopyranose mutase
HN014_20535	COG0438	transferase activity, transferring glycosyl groups
HN014_20540	COG0739	heme binding
HN014_20550	COG1104	cysteine desulfurase activity
HN014_20590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN014_20615	COG0116	Belongs to the methyltransferase superfamily
HN014_20665	COG1363	Peptidase, m42
HN014_20670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HN014_20675	COG0745	RESPONSE REGULATOR receiver
HN014_20680	COG5002	protein histidine kinase activity
HN014_20690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN014_20715	COG0783	Belongs to the Dps family
HN014_20745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_20750	COG0705	Rhomboid family
HN014_20760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HN014_20775	COG0405	Gamma-glutamyltransferase
HN014_20795	COG0443	Heat shock 70 kDa protein
HN014_20800	COG1760	l-serine dehydratase
HN014_20815	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HN014_20820	COG0564	pseudouridine synthase activity
HN014_20850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HN014_20855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HN014_20860	COG0066	3-isopropylmalate dehydratase activity
HN014_20865	COG0473	3-isopropylmalate dehydrogenase activity
HN014_20870	COG2363	Small membrane protein
HN014_20900	COG3012	SEC-C Motif Domain Protein
HN014_20925	COG4251	negative regulation of phosphorylation
HN014_20935	COG0745	RESPONSE REGULATOR receiver
HN014_20940	COG2201	protein-glutamate methylesterase activity
HN014_20950	COG0511	ligase activity, forming carbon-carbon bonds
HN014_20955	COG0439	Biotin carboxylase
HN014_20960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HN014_20970	COG0165	Argininosuccinate lyase
HN014_20980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HN014_20990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN014_21000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HN014_21005	COG0137	argininosuccinate synthase activity
HN014_21015	COG1506	peptidase
HN014_21020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HN014_21025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HN014_21035	COG0028	Belongs to the TPP enzyme family
HN014_21040	COG0129	dihydroxy-acid dehydratase activity
HN014_21045	COG2197	response regulator
HN014_21050	COG4585	Histidine kinase
HN014_21070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HN014_21075	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HN014_21080	COG1914	H( )-stimulated, divalent metal cation uptake system
HN014_21090	COG1222	aaa ATPase
HN014_21150	COG3501	Rhs element vgr protein
HN014_21270	COG0673	inositol 2-dehydrogenase activity
HN014_21275	COG0745	RESPONSE REGULATOR receiver
HN014_21275	COG3292	Two component regulator propeller
HN014_21275	COG2205	protein histidine kinase activity
HN014_21280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HN014_21285	COG1702	phosphate starvation-inducible protein PhoH
HN014_21310	COG0592	DNA-directed DNA polymerase activity
HN014_21340	COG0067	glutamate synthase
HN014_21340	COG0070	glutamate synthase
HN014_21340	COG0069	glutamate synthase activity
HN014_21350	COG0004	ammonium transporteR
HN014_21355	COG0784	Response regulator, receiver
HN014_21355	COG2205	protein histidine kinase activity
HN014_21355	COG5002	protein histidine kinase activity
HN014_21360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HN014_21370	COG0641	radical SAM
HN014_21415	COG0612	Peptidase, M16
HN014_21425	COG0606	chelatase, subunit chli
HN014_21430	COG0527	aspartate kinase activity
HN014_21445	COG3590	peptidase
HN014_21470	COG3437	response regulator, receiver
HN014_21470	COG2205	protein histidine kinase activity
HN014_21470	COG4999	Histidine kinase
HN014_21470	COG3850	Histidine kinase
HN014_21500	COG0205	6-phosphofructokinase activity
HN014_21505	COG2274	protein secretion by the type I secretion system
HN014_21520	COG2198	Histidine kinase
HN014_21520	COG5002	protein histidine kinase activity
HN014_21520	COG0784	Response regulator, receiver
HN014_21540	COG0037	tRNA processing
HN014_21555	COG0431	NADPH-dependent FMN reductase
HN014_21560	COG0523	cobalamin synthesis protein
HN014_21580	COG0513	Belongs to the DEAD box helicase family
HN014_21585	COG1988	membrane-bound metal-dependent
HN014_21590	COG1132	(ABC) transporter
HN014_21615	COG4977	sequence-specific DNA binding
HN014_21620	COG0612	Peptidase, M16
HN014_21635	COG4771	TonB-dependent receptor
HN014_21660	COG0308	aminopeptidase N
HN014_21675	COG1522	sequence-specific DNA binding
HN014_21690	COG3279	Response regulator of the LytR AlgR family
HN014_21695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN014_21715	COG3279	Response regulator of the LytR AlgR family
HN014_21720	COG3275	phosphorelay sensor kinase activity
HN014_21730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HN014_21765	COG0542	response to heat
HN014_21775	COG1309	transcriptional regulator
HN014_21805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HN014_21810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HN014_21815	COG0673	inositol 2-dehydrogenase activity
HN014_21820	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_21840	COG2176	DNA-directed DNA polymerase activity
HN014_21845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN014_21850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HN014_21880	COG4974	Belongs to the 'phage' integrase family
HN014_21970	COG0563	adenylate kinase activity
HN014_22010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HN014_22015	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HN014_22020	COG0497	DNA recombination
HN014_22050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN014_22065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HN014_22075	COG2890	protein-(glutamine-N5) methyltransferase activity
HN014_22090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN014_22090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN014_22105	COG1739	Uncharacterized protein family UPF0029
HN014_22110	COG0824	Thioesterase
HN014_22145	COG1192	Involved in chromosome partitioning
HN014_22195	COG0629	single-stranded DNA binding
HN014_22300	COG1192	Involved in chromosome partitioning
HN014_22315	COG3328	transposase activity
HN014_22360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HN014_22545	COG2003	Belongs to the UPF0758 family