locus-tag	class	description
HYN46_00105	COG3772	lysozyme
HYN46_00120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYN46_00130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYN46_00135	COG0861	Integral membrane protein TerC family
HYN46_00140	COG3123	guanosine phosphorylase activity
HYN46_00150	COG0497	DNA recombination
HYN46_00160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYN46_00165	COG0671	phosphoesterase, PA-phosphatase related
HYN46_00170	COG0668	transmembrane transport
HYN46_00180	COG5265	(ABC) transporter
HYN46_00220	COG4771	TonB-dependent receptor
HYN46_00230	COG2814	Major facilitator Superfamily
HYN46_00245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYN46_00255	COG0243	molybdopterin cofactor binding
HYN46_00355	COG1450	Type ii and iii secretion system protein
HYN46_00410	COG4399	Belongs to the UPF0754 family
HYN46_00430	COG4302	ethanolamine ammonia-lyase activity
HYN46_00435	COG4303	Ethanolamine ammonia lyase large subunit
HYN46_00440	COG0531	amino acid
HYN46_00445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYN46_00450	COG1349	DNA-binding transcription factor activity
HYN46_00455	COG2188	Transcriptional regulator
HYN46_00460	COG1840	ABC-type Fe3 transport system, periplasmic component
HYN46_00465	COG3842	ATPase activity
HYN46_00480	COG3511	phospholipase C
HYN46_00485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYN46_00495	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HYN46_00500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HYN46_00540	COG0560	Phosphoserine phosphatase
HYN46_00540	COG3830	Belongs to the UPF0237 family
HYN46_00570	COG4969	Belongs to the N-Me-Phe pilin family
HYN46_00580	COG0228	four-way junction DNA binding
HYN46_00585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYN46_00595	COG0335	large ribosomal subunit rRNA binding
HYN46_00600	COG0142	geranyltranstransferase activity
HYN46_00625	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYN46_00665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYN46_00675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYN46_00685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYN46_00695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYN46_00695	COG2813	Specifically methylates the guanine in position
HYN46_00700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYN46_00705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYN46_00720	COG2853	Lipoprotein
HYN46_00750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYN46_00755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HYN46_00760	COG0537	adenosine 5'-monophosphoramidase activity
HYN46_00770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYN46_00775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYN46_00780	COG3622	Belongs to the hyi family
HYN46_00785	COG2084	Dehydrogenase
HYN46_00815	COG1686	Belongs to the peptidase S11 family
HYN46_00875	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HYN46_00895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYN46_00915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYN46_00925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HYN46_00925	COG0140	phosphoribosyl-ATP diphosphatase activity
HYN46_00930	COG2814	Major facilitator Superfamily
HYN46_00940	COG2205	protein histidine kinase activity
HYN46_00945	COG0745	RESPONSE REGULATOR receiver
HYN46_00955	COG1403	HNH endonuclease
HYN46_00975	COG0795	lipopolysaccharide-transporting ATPase activity
HYN46_00985	COG2813	Specifically methylates the guanine in position
HYN46_00995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYN46_01000	COG0189	ligase activity
HYN46_01005	COG1742	UPF0060 membrane protein
HYN46_01020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYN46_01035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HYN46_01045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYN46_01060	COG0739	heme binding
HYN46_01065	COG2983	Belongs to the UPF0260 family
HYN46_01075	COG0517	IMP dehydrogenase activity
HYN46_01075	COG0516	GMP reductase activity
HYN46_01085	COG3220	belongs to the UPF0276 family
HYN46_01115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYN46_01135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HYN46_01145	COG0463	Glycosyl transferase, family 2
HYN46_01155	COG0642	Histidine kinase
HYN46_01175	COG3162	membrane
HYN46_01180	COG2198	Histidine kinase
HYN46_01180	COG0784	Response regulator, receiver
HYN46_01180	COG2205	protein histidine kinase activity
HYN46_01190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYN46_01195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYN46_01195	COG4797	methyltransferase
HYN46_01235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYN46_01235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYN46_01250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HYN46_01255	COG0339	signal peptide processing
HYN46_01260	COG0557	exoribonuclease II activity
HYN46_01270	COG0628	permease
HYN46_01295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN46_01320	COG0326	Molecular chaperone. Has ATPase activity
HYN46_01350	COG1538	Outer membrane efflux protein
HYN46_01360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN46_01365	COG0745	RESPONSE REGULATOR receiver
HYN46_01375	COG1132	(ABC) transporter
HYN46_01420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYN46_01480	COG3437	response regulator, receiver
HYN46_01485	COG0784	Response regulator, receiver
HYN46_01485	COG2198	Histidine kinase
HYN46_01485	COG5002	protein histidine kinase activity
HYN46_01490	COG0683	leucine binding
HYN46_01515	COG0746	molybdenum cofactor guanylyltransferase activity
HYN46_01525	COG1968	undecaprenyl-diphosphatase activity
HYN46_01540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HYN46_01570	COG0596	Alpha beta hydrolase
HYN46_01580	COG4269	membrane
HYN46_01595	COG0501	Belongs to the peptidase M48B family
HYN46_01600	COG2910	NAD(P)H-binding
HYN46_01610	COG0583	DNA-binding transcription factor activity
HYN46_01625	COG0183	Belongs to the thiolase family
HYN46_01645	COG0728	peptidoglycan biosynthetic process
HYN46_01650	COG0196	riboflavin kinase activity
HYN46_01655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYN46_01660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYN46_01665	COG1047	Peptidyl-prolyl cis-trans
HYN46_01715	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_01725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HYN46_01740	COG3275	phosphorelay sensor kinase activity
HYN46_01750	COG0181	hydroxymethylbilane synthase activity
HYN46_01785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYN46_01800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYN46_01805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HYN46_01815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HYN46_01820	COG0131	Imidazoleglycerol-phosphate dehydratase
HYN46_01835	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_01840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYN46_01850	COG3321	synthase
HYN46_01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYN46_01855	COG0604	alcohol dehydrogenase
HYN46_01855	COG3321	synthase
HYN46_01870	COG2267	carboxylic ester hydrolase activity
HYN46_01885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN46_01890	COG1136	(ABC) transporter
HYN46_01895	COG0577	efflux transmembrane transporter activity
HYN46_01895	COG1136	(ABC) transporter
HYN46_01900	COG0577	efflux transmembrane transporter activity
HYN46_01900	COG1136	(ABC) transporter
HYN46_01940	COG3829	transcription factor binding
HYN46_01975	COG1196	nuclear chromosome segregation
HYN46_01975	COG0739	heme binding
HYN46_01975	COG0741	lytic transglycosylase activity
HYN46_01985	COG0573	inorganic phosphate transmembrane transporter activity
HYN46_01990	COG0581	inorganic phosphate transmembrane transporter activity
HYN46_02005	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HYN46_02010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYN46_02020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HYN46_02020	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HYN46_02025	COG0730	response to heat
HYN46_02035	COG0751	glycine-tRNA ligase activity
HYN46_02060	COG2267	carboxylic ester hydrolase activity
HYN46_02075	COG0793	Belongs to the peptidase S41A family
HYN46_02085	COG4452	Inner membrane protein CreD
HYN46_02100	COG0583	DNA-binding transcription factor activity
HYN46_02105	COG2081	HI0933 family
HYN46_02110	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYN46_02125	COG1022	Amp-dependent synthetase and ligase
HYN46_02130	COG0525	valine-tRNA ligase activity
HYN46_02135	COG0300	oxidoreductase activity
HYN46_02140	COG1538	Outer membrane efflux protein
HYN46_02145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN46_02150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN46_02155	COG2258	MOSC domain
HYN46_02175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYN46_02180	COG2885	chlorophyll binding
HYN46_02185	COG2199	diguanylate cyclase activity
HYN46_02195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HYN46_02200	COG0300	oxidoreductase activity
HYN46_02205	COG1253	flavin adenine dinucleotide binding
HYN46_02210	COG0513	Belongs to the DEAD box helicase family
HYN46_02220	COG1648	precorrin-2 dehydrogenase activity
HYN46_02220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HYN46_02235	COG2969	positive regulation of protein catabolic process
HYN46_02240	COG0625	glutathione transferase activity
HYN46_02265	COG2857	Cytochrome c1
HYN46_02270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HYN46_02275	COG0723	plastoquinol--plastocyanin reductase activity
HYN46_02285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYN46_02290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYN46_02295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYN46_02300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYN46_02325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYN46_02340	COG2267	carboxylic ester hydrolase activity
HYN46_02345	COG0606	chelatase, subunit chli
HYN46_02355	COG0347	Belongs to the P(II) protein family
HYN46_02360	COG0004	ammonium transporteR
HYN46_02365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYN46_02370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYN46_02370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYN46_02395	COG0772	Belongs to the SEDS family
HYN46_02400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYN46_02410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HYN46_02440	COG2818	Glycosylase
HYN46_02455	COG3708	Transcriptional regulator
HYN46_02455	COG2207	Transcriptional regulator
HYN46_02470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYN46_02485	COG1519	Transferase
HYN46_02490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYN46_02515	COG0489	protein tyrosine kinase activity
HYN46_02520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYN46_02520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYN46_02530	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HYN46_02535	COG1162	GTPase activity
HYN46_02540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYN46_02550	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HYN46_02555	COG0668	transmembrane transport
HYN46_02600	COG4591	ABC-type transport system involved in lipoprotein release permease component
HYN46_02605	COG1136	(ABC) transporter
HYN46_02615	COG2333	competence protein COMEC
HYN46_02615	COG0658	competence protein
HYN46_02650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYN46_02665	COG0072	phenylalanine-tRNA ligase activity
HYN46_02685	COG2937	Belongs to the GPAT DAPAT family
HYN46_02690	COG0598	Magnesium transport protein CorA
HYN46_02695	COG1946	Acyl-CoA thioesterase
HYN46_02715	COG2914	Belongs to the UPF0125 (RnfH) family
HYN46_02720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYN46_02725	COG0735	belongs to the Fur family
HYN46_02730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYN46_02755	COG4771	TonB-dependent receptor
HYN46_02765	COG4166	transmembrane transport
HYN46_02770	COG0601	transmembrane transport
HYN46_02775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYN46_02780	COG4172	Belongs to the ABC transporter superfamily
HYN46_02795	COG1116	anion transmembrane transporter activity
HYN46_02800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_02810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYN46_02815	COG3707	response regulator
HYN46_02855	COG0737	Belongs to the 5'-nucleotidase family
HYN46_02860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYN46_02870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYN46_02890	COG1309	transcriptional regulator
HYN46_02895	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYN46_02900	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYN46_02905	COG3845	ABC transporter
HYN46_02920	COG1335	isochorismatase
HYN46_02995	COG1045	serine acetyltransferase
HYN46_03000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYN46_03005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYN46_03060	COG0067	glutamate synthase
HYN46_03060	COG0069	glutamate synthase activity
HYN46_03060	COG0070	glutamate synthase
HYN46_03065	COG0493	'glutamate synthase
HYN46_03080	COG0683	leucine binding
HYN46_03085	COG1704	LemA family
HYN46_03090	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYN46_03145	COG0662	Cupin 2, conserved barrel domain protein
HYN46_03155	COG2130	NADP-dependent
HYN46_03165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYN46_03170	COG0277	FAD linked oxidase domain protein
HYN46_03180	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYN46_03205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HYN46_03220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYN46_03265	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HYN46_03275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN46_03280	COG0438	transferase activity, transferring glycosyl groups
HYN46_03315	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HYN46_03315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYN46_03330	COG2917	probably involved in intracellular septation
HYN46_03335	COG0613	PHP domain protein
HYN46_03340	COG3781	membrane
HYN46_03345	COG2003	Belongs to the UPF0758 family
HYN46_03360	COG3422	double-strand break repair
HYN46_03375	COG0354	folic acid binding
HYN46_03385	COG1560	Kdo2-lipid A biosynthetic process
HYN46_03395	COG0488	(ABC) transporter
HYN46_03400	COG2900	Belongs to the SlyX family
HYN46_03420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_03440	COG1858	cytochrome C peroxidase
HYN46_03455	COG0633	Ferredoxin
HYN46_03455	COG3217	Mosc domain protein beta barrel domain protein
HYN46_03480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYN46_03480	COG4651	solute:proton antiporter activity
HYN46_03500	COG1309	transcriptional regulator
HYN46_03510	COG0788	formyltetrahydrofolate deformylase activity
HYN46_03515	COG2223	nitrite transmembrane transporter activity
HYN46_03525	COG1823	symporter activity
HYN46_03530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYN46_03535	COG2814	Major facilitator Superfamily
HYN46_03580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYN46_03585	COG1960	acyl-CoA dehydrogenase activity
HYN46_03590	COG1024	Enoyl-CoA hydratase
HYN46_03600	COG0724	RNA recognition motif
HYN46_03605	COG4628	conserved protein (DUF2132)
HYN46_03610	COG1960	acyl-CoA dehydrogenase activity
HYN46_03630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYN46_03635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYN46_03640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYN46_03645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_03650	COG1116	anion transmembrane transporter activity
HYN46_03655	COG2153	protein acetylation
HYN46_03660	COG0114	fumarate hydratase activity
HYN46_03675	COG2814	Major facilitator Superfamily
HYN46_03680	COG1505	serine-type exopeptidase activity
HYN46_03685	COG0612	Peptidase, M16
HYN46_03695	COG1960	acyl-CoA dehydrogenase activity
HYN46_03700	COG1960	acyl-CoA dehydrogenase activity
HYN46_03705	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HYN46_03720	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HYN46_03740	COG2096	Adenosyltransferase
HYN46_03745	COG0110	maltose O-acetyltransferase activity
HYN46_03750	COG4206	TonB-dependent receptor
HYN46_03770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYN46_03775	COG0285	dihydrofolate synthase activity
HYN46_03790	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HYN46_03790	COG2755	lipolytic protein G-D-S-L family
HYN46_03820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYN46_03830	COG1690	Belongs to the RtcB family
HYN46_03855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYN46_03860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYN46_03870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HYN46_03875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HYN46_03880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HYN46_03885	COG2205	protein histidine kinase activity
HYN46_03890	COG0745	RESPONSE REGULATOR receiver
HYN46_03905	COG0009	L-threonylcarbamoyladenylate synthase
HYN46_03915	COG1399	metal-binding, possibly nucleic acid-binding protein
HYN46_03930	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_03935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYN46_03940	COG1652	LysM domain
HYN46_03975	COG4206	TonB-dependent receptor
HYN46_03980	COG1858	cytochrome C peroxidase
HYN46_03985	COG3511	phospholipase C
HYN46_03990	COG4774	siderophore transport
HYN46_04070	COG1309	transcriptional regulator
HYN46_04075	COG1979	alcohol dehydrogenase
HYN46_04080	COG2130	NADP-dependent
HYN46_04095	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYN46_04095	COG1902	pentaerythritol trinitrate reductase activity
HYN46_04100	COG1695	Transcriptional regulator
HYN46_04120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HYN46_04130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HYN46_04135	COG0542	response to heat
HYN46_04140	COG1393	Belongs to the ArsC family
HYN46_04145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYN46_04165	COG2226	methyltransferase
HYN46_04170	COG1011	Hydrolase
HYN46_04210	COG0306	phosphate transporter
HYN46_04225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYN46_04290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYN46_04290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYN46_04315	COG2009	succinate dehydrogenase
HYN46_04320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HYN46_04325	COG1053	succinate dehydrogenase
HYN46_04330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYN46_04345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYN46_04350	COG0045	succinate-CoA ligase (ADP-forming) activity
HYN46_04385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYN46_04415	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_04420	COG0583	DNA-binding transcription factor activity
HYN46_04425	COG2070	2-Nitropropane dioxygenase
HYN46_04450	COG0339	signal peptide processing
HYN46_04455	COG4807	Protein conserved in bacteria
HYN46_04485	COG0204	Acyl-transferase
HYN46_04490	COG2885	chlorophyll binding
HYN46_04490	COG3047	cAMP biosynthetic process
HYN46_04505	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HYN46_04520	COG0552	protein localization to endoplasmic reticulum
HYN46_04530	COG0504	CTP synthase activity
HYN46_04535	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HYN46_04545	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HYN46_04560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYN46_04570	COG3122	Protein conserved in bacteria
HYN46_04615	COG2137	regulation of response to DNA damage stimulus
HYN46_04625	COG2207	Transcriptional regulator
HYN46_04630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN46_04635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYN46_04640	COG1960	acyl-CoA dehydrogenase activity
HYN46_04645	COG1960	acyl-CoA dehydrogenase activity
HYN46_04660	COG2850	peptidyl-arginine hydroxylation
HYN46_04670	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HYN46_04685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYN46_04690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HYN46_04695	COG2199	diguanylate cyclase activity
HYN46_04700	COG1067	ATP-dependent peptidase activity
HYN46_04710	COG2814	Major facilitator Superfamily
HYN46_04720	COG1733	regulation of RNA biosynthetic process
HYN46_04740	COG0564	pseudouridine synthase activity
HYN46_04745	COG1496	oxidoreductase activity
HYN46_04765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYN46_04795	COG3829	transcription factor binding
HYN46_04835	COG0431	NADPH-dependent FMN reductase
HYN46_04855	COG1960	acyl-CoA dehydrogenase activity
HYN46_04870	COG2233	PERMEase
HYN46_04875	COG1309	transcriptional regulator
HYN46_04900	COG0495	leucyl-tRNA aminoacylation
HYN46_04915	COG0028	Belongs to the TPP enzyme family
HYN46_04920	COG0440	acetolactate synthase activity
HYN46_04925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYN46_04965	COG2814	Major facilitator Superfamily
HYN46_04975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYN46_04980	COG0509	glycine decarboxylation via glycine cleavage system
HYN46_04985	COG0626	cystathionine gamma-synthase activity
HYN46_04995	COG4771	TonB-dependent receptor
HYN46_05000	COG0644	oxidoreductase
HYN46_05000	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HYN46_05010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYN46_05055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYN46_05065	COG1764	response to oxidative stress
HYN46_05070	COG1846	Transcriptional regulator
HYN46_05080	COG4521	taurine ABC transporter
HYN46_05085	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HYN46_05090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_05095	COG2175	clavaminate synthase activity
HYN46_05120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYN46_05135	COG0789	Transcriptional regulator
HYN46_05140	COG1902	pentaerythritol trinitrate reductase activity
HYN46_05140	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYN46_05170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYN46_05190	COG0167	dihydroorotate dehydrogenase activity
HYN46_05210	COG0494	nUDIX hydrolase
HYN46_05235	COG0482	sulfurtransferase activity
HYN46_05245	COG0315	cyclic pyranopterin monophosphate synthase activity
HYN46_05250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HYN46_05265	COG2897	thiosulfate sulfurtransferase activity
HYN46_05270	COG1686	Belongs to the peptidase S11 family
HYN46_05280	COG0193	aminoacyl-tRNA hydrolase activity
HYN46_05285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYN46_05290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYN46_05305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYN46_05310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HYN46_05325	COG2353	YceI-like domain
HYN46_05335	COG1720	tRNA m6t6A37 methyltransferase activity
HYN46_05340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYN46_05345	COG1051	belongs to the nudix hydrolase family
HYN46_05345	COG1056	cytidyltransferase-related domain
HYN46_05365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYN46_05380	COG1309	transcriptional regulator
HYN46_05390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN46_05400	COG2010	Cytochrome c
HYN46_05415	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HYN46_05480	COG4771	TonB-dependent receptor
HYN46_05485	COG4771	TonB-dependent receptor
HYN46_05525	COG0308	aminopeptidase N
HYN46_05530	COG2733	membrane
HYN46_05535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYN46_05545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYN46_05550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYN46_05555	COG0109	protoheme IX farnesyltransferase activity
HYN46_05565	COG1845	cytochrome c oxidase, subunit III
HYN46_05570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYN46_05575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HYN46_05580	COG2814	Major facilitator Superfamily
HYN46_05585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYN46_05600	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYN46_05625	COG0776	regulation of translation
HYN46_05645	COG0268	Binds directly to 16S ribosomal RNA
HYN46_05650	COG0702	epimerase
HYN46_05655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYN46_05665	COG0653	protein targeting
HYN46_05670	COG0302	gtp cyclohydrolase
HYN46_05690	COG0512	Glutamine amidotransferase of anthranilate synthase
HYN46_05695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYN46_05700	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HYN46_05710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYN46_05715	COG3139	Protein of unknown function (DUF1315)
HYN46_05720	COG0616	signal peptide processing
HYN46_05760	COG2323	membrane
HYN46_05765	COG0126	phosphoglycerate kinase activity
HYN46_05790	COG3161	chorismate lyase activity
HYN46_05795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HYN46_05800	COG0802	atpase or kinase
HYN46_05805	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYN46_05810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYN46_05815	COG1923	regulation of RNA biosynthetic process
HYN46_05820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYN46_05830	COG3178	'Phosphotransferase
HYN46_05835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYN46_05840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HYN46_05910	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HYN46_05920	COG1136	(ABC) transporter
HYN46_05935	COG0745	RESPONSE REGULATOR receiver
HYN46_05940	COG2205	protein histidine kinase activity
HYN46_05960	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_05970	COG2030	dehydratase
HYN46_06000	COG0402	S-adenosylhomocysteine deaminase activity
HYN46_06005	COG2814	Major facilitator Superfamily
HYN46_06010	COG3047	cAMP biosynthetic process
HYN46_06030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HYN46_06040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYN46_06045	COG1011	Hydrolase
HYN46_06050	COG1218	3'(2'),5'-bisphosphate nucleotidase
HYN46_06060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HYN46_06065	COG0730	response to heat
HYN46_06070	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN46_06075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYN46_06080	COG1368	sulfuric ester hydrolase activity
HYN46_06085	COG1960	acyl-CoA dehydrogenase activity
HYN46_06090	COG1297	OPT oligopeptide transporter protein
HYN46_06095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYN46_06110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYN46_06135	COG3079	Belongs to the UPF0149 family
HYN46_06140	COG0006	proline dipeptidase activity
HYN46_06145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYN46_06150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYN46_06165	COG3107	peptidoglycan biosynthetic process
HYN46_06170	COG0792	nuclease activity
HYN46_06185	COG0400	carboxylic ester hydrolase activity
HYN46_06205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HYN46_06210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYN46_06215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYN46_06220	COG0450	alkyl hydroperoxide reductase
HYN46_06225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYN46_06230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYN46_06235	COG0625	glutathione transferase activity
HYN46_06240	COG0564	pseudouridine synthase activity
HYN46_06245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYN46_06270	COG0352	thiamine-phosphate diphosphorylase activity
HYN46_06295	COG2119	membrane
HYN46_06300	COG0583	DNA-binding transcription factor activity
HYN46_06305	COG2814	Major facilitator Superfamily
HYN46_06310	COG0656	L-ascorbic acid biosynthetic process
HYN46_06325	COG0545	Peptidyl-prolyl cis-trans isomerase
HYN46_06340	COG1272	protein, Hemolysin III
HYN46_06345	COG0697	spore germination
HYN46_06385	COG4681	YaeQ
HYN46_06390	COG0625	glutathione transferase activity
HYN46_06420	COG2363	Small membrane protein
HYN46_06430	COG2255	four-way junction helicase activity
HYN46_06455	COG4149	molybdate abc transporter
HYN46_06460	COG0725	ABC transporter, periplasmic molybdate-binding protein
HYN46_06465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYN46_06465	COG0047	phosphoribosylformylglycinamidine synthase activity
HYN46_06475	COG1024	Enoyl-CoA hydratase
HYN46_06485	COG1045	serine acetyltransferase
HYN46_06510	COG0436	Aminotransferase
HYN46_06520	COG0386	Belongs to the glutathione peroxidase family
HYN46_06530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYN46_06535	COG0004	ammonium transporteR
HYN46_06540	COG3152	Membrane
HYN46_06545	COG1252	NADH dehydrogenase
HYN46_06555	COG0318	PFAM AMP-dependent synthetase and ligase
HYN46_06565	COG1187	pseudouridine synthase activity
HYN46_06595	COG3291	Pkd domain containing protein
HYN46_06600	COG3291	Pkd domain containing protein
HYN46_06605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYN46_06610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYN46_06615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYN46_06625	COG1764	response to oxidative stress
HYN46_06630	COG0475	glutathione-regulated potassium exporter activity
HYN46_06640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYN46_06645	COG5002	protein histidine kinase activity
HYN46_06655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HYN46_06680	COG1671	Belongs to the UPF0178 family
HYN46_06720	COG0316	Belongs to the HesB IscA family
HYN46_06725	COG0822	iron-sulfur transferase activity
HYN46_06755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYN46_06765	COG0778	Nitroreductase
HYN46_06770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYN46_06810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HYN46_06830	COG0602	queuosine metabolic process
HYN46_06840	COG0511	ligase activity, forming carbon-carbon bonds
HYN46_06860	COG0513	Belongs to the DEAD box helicase family
HYN46_06880	COG0583	DNA-binding transcription factor activity
HYN46_06885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_06890	COG1116	anion transmembrane transporter activity
HYN46_06895	COG1960	acyl-CoA dehydrogenase activity
HYN46_06900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYN46_06910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYN46_06920	COG0477	Major facilitator Superfamily
HYN46_06975	COG2995	paraquat-inducible protein a
HYN46_06980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HYN46_06980	COG3008	intermembrane lipid transfer
HYN46_07005	COG3852	Histidine kinase
HYN46_07025	COG3209	COG3209 Rhs family protein
HYN46_07060	COG0582	viral genome integration into host DNA
HYN46_07100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYN46_07105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYN46_07135	COG2067	long-chain fatty acid transport protein
HYN46_07140	COG1902	pentaerythritol trinitrate reductase activity
HYN46_07140	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYN46_07165	COG0560	Phosphoserine phosphatase
HYN46_07175	COG0069	glutamate synthase activity
HYN46_07180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HYN46_07190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYN46_07220	COG3842	ATPase activity
HYN46_07225	COG1840	ABC-type Fe3 transport system, periplasmic component
HYN46_07245	COG1944	ATP diphosphatase activity
HYN46_07285	COG2706	6-phosphogluconolactonase activity
HYN46_07305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYN46_07315	COG0824	Thioesterase
HYN46_07335	COG0823	Involved in the tonB-independent uptake of proteins
HYN46_07345	COG1960	acyl-CoA dehydrogenase activity
HYN46_07350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYN46_07395	COG0500	methyltransferase
HYN46_07410	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HYN46_07420	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HYN46_07425	COG1137	ATPase activity
HYN46_07435	COG1024	Enoyl-CoA hydratase
HYN46_07445	COG0420	3'-5' exonuclease activity
HYN46_07475	COG1187	pseudouridine synthase activity
HYN46_07485	COG0154	amidase activity
HYN46_07500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYN46_07530	COG2911	Protein conserved in bacteria
HYN46_07535	COG0729	surface antigen
HYN46_07560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HYN46_07570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYN46_07575	COG2890	protein-(glutamine-N5) methyltransferase activity
HYN46_07600	COG1253	flavin adenine dinucleotide binding
HYN46_07615	COG0360	Binds together with S18 to 16S ribosomal RNA
HYN46_07620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYN46_07630	COG0305	Participates in initiation and elongation during chromosome replication
HYN46_07635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYN46_07640	COG0739	heme binding
HYN46_07640	COG0741	lytic transglycosylase activity
HYN46_07640	COG1196	nuclear chromosome segregation
HYN46_07650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN46_07655	COG1136	(ABC) transporter
HYN46_07655	COG0577	efflux transmembrane transporter activity
HYN46_07675	COG4172	Belongs to the ABC transporter superfamily
HYN46_07680	COG4239	(ABC) transporter, permease
HYN46_07685	COG4174	ABC transporter (Permease)
HYN46_07695	COG0741	lytic transglycosylase activity
HYN46_07695	COG1388	LysM domain
HYN46_07700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYN46_07765	COG0668	transmembrane transport
HYN46_07780	COG0330	HflC and HflK could
HYN46_07785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HYN46_07790	COG1381	Involved in DNA repair and RecF pathway recombination
HYN46_07800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYN46_07805	COG0571	ribonuclease III activity
HYN46_07815	COG0681	Belongs to the peptidase S26 family
HYN46_07820	COG0481	GTPase activity
HYN46_07840	COG1773	rubredoxin
HYN46_07845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYN46_07855	COG0583	DNA-binding transcription factor activity
HYN46_07895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HYN46_07900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYN46_07915	COG1051	belongs to the nudix hydrolase family
HYN46_07915	COG1056	cytidyltransferase-related domain
HYN46_07925	COG3243	poly(R)-hydroxyalkanoic acid synthase
HYN46_07935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYN46_07945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYN46_07960	COG0765	amino acid transport
HYN46_07965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYN46_07980	COG1794	racemase activity, acting on amino acids and derivatives
HYN46_08000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYN46_08010	COG1643	Atp-dependent helicase
HYN46_08045	COG0084	hydrolase, TatD family'
HYN46_08055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYN46_08065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HYN46_08070	COG1663	tetraacyldisaccharide 4'-kinase activity
HYN46_08075	COG1132	(ABC) transporter
HYN46_08090	COG1475	DNA binding
HYN46_08095	COG1192	Involved in chromosome partitioning
HYN46_08125	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYN46_08125	COG1902	pentaerythritol trinitrate reductase activity
HYN46_08130	COG1309	transcriptional regulator
HYN46_08200	COG2354	Protein conserved in bacteria
HYN46_08205	COG0714	Associated with various cellular activities
HYN46_08210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYN46_08220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYN46_08235	COG0049	tRNA binding
HYN46_08250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYN46_08260	COG1981	membrane
HYN46_08270	COG2207	Transcriptional regulator
HYN46_08285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYN46_08300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HYN46_08305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYN46_08335	COG0628	permease
HYN46_08345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYN46_08350	COG0405	Gamma-glutamyltransferase
HYN46_08360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYN46_08370	COG1047	Peptidyl-prolyl cis-trans
HYN46_08440	COG0527	aspartate kinase activity
HYN46_08475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HYN46_08480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYN46_08485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYN46_08495	COG1454	alcohol dehydrogenase
HYN46_08500	COG0824	Thioesterase
HYN46_08510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYN46_08520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYN46_08525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HYN46_08530	COG4181	ATPase activity
HYN46_08555	COG3210	domain, Protein
HYN46_08575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYN46_08585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HYN46_08590	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HYN46_08615	COG0586	Pfam SNARE associated Golgi protein
HYN46_08635	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN46_08645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYN46_08650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYN46_08655	COG2207	Transcriptional regulator
HYN46_08665	COG0183	Belongs to the thiolase family
HYN46_08670	COG1024	Enoyl-CoA hydratase
HYN46_08670	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYN46_08690	COG1012	belongs to the aldehyde dehydrogenase family
HYN46_08700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYN46_08705	COG2814	Major facilitator Superfamily
HYN46_08715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYN46_08740	COG2223	nitrite transmembrane transporter activity
HYN46_08750	COG2146	nitrite reductase [NAD(P)H] activity
HYN46_08750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYN46_08755	COG0243	molybdopterin cofactor binding
HYN46_08760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYN46_08765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYN46_08780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HYN46_08795	COG0425	Belongs to the sulfur carrier protein TusA family
HYN46_08800	COG4535	Mg2 and Co2 transporter CorC
HYN46_08805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYN46_08810	COG0523	cobalamin synthesis protein
HYN46_08815	COG1741	Belongs to the pirin family
HYN46_08820	COG2259	Doxx family
HYN46_08840	COG1295	ribonuclease BN
HYN46_08845	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN46_08850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYN46_08855	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN46_08865	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYN46_08875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYN46_08880	COG0575	Belongs to the CDS family
HYN46_08885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYN46_08890	COG0233	cytoplasmic translational termination
HYN46_08900	COG0625	glutathione transferase activity
HYN46_08905	COG1309	transcriptional regulator
HYN46_08910	COG3011	Protein conserved in bacteria
HYN46_08930	COG2391	methyltransferase activity
HYN46_08940	COG3040	lipid binding
HYN46_08965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYN46_08970	COG0052	Belongs to the universal ribosomal protein uS2 family
HYN46_08975	COG0024	Methionine aminopeptidase
HYN46_08985	COG0436	Aminotransferase
HYN46_09000	COG0706	membrane insertase activity
HYN46_09010	COG3706	GGDEF domain
HYN46_09025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYN46_09030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYN46_09075	COG0556	nucleotide-excision repair
HYN46_09080	COG0436	Aminotransferase
HYN46_09100	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYN46_09110	COG4932	domain protein
HYN46_09110	COG5492	domain, Protein
HYN46_09155	COG2264	protein methyltransferase activity
HYN46_09170	COG0138	bifunctional purine biosynthesis protein purh
HYN46_09175	COG0151	Belongs to the GarS family
HYN46_09180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYN46_09185	COG0321	lipoyl(octanoyl) transferase activity
HYN46_09205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HYN46_09210	COG2046	Belongs to the sulfate adenylyltransferase family
HYN46_09215	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HYN46_09235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYN46_09240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYN46_09250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HYN46_09255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYN46_09260	COG2808	Putative FMN-binding domain
HYN46_09270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYN46_09275	COG5001	Diguanylate cyclase
HYN46_09275	COG3300	MHYT domain
HYN46_09295	COG2921	Belongs to the UPF0250 family
HYN46_09300	COG2814	Major facilitator Superfamily
HYN46_09310	COG0028	Belongs to the TPP enzyme family
HYN46_09325	COG1966	Carbon starvation protein
HYN46_09345	COG0124	histidyl-tRNA synthetase
HYN46_09380	COG2975	iron-sulfur cluster assembly
HYN46_09385	COG1113	amino acid transport
HYN46_09395	COG2070	2-Nitropropane dioxygenase
HYN46_09400	COG1451	nucleotide metabolic process
HYN46_09420	COG2308	Evidence 4 Homologs of previously reported genes of
HYN46_09425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYN46_09430	COG0019	diaminopimelate decarboxylase activity
HYN46_09450	COG1597	lipid kinase activity
HYN46_09495	COG0564	pseudouridine synthase activity
HYN46_09510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HYN46_09515	COG1183	phosphatidylcholine synthase activity
HYN46_09525	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HYN46_09540	COG0582	viral genome integration into host DNA
HYN46_09600	COG1131	(ABC) transporter
HYN46_09605	COG0842	Transport permease protein
HYN46_09620	COG0772	Belongs to the SEDS family
HYN46_09625	COG2951	lytic endotransglycosylase activity
HYN46_09645	COG0542	response to heat
HYN46_09660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYN46_09675	COG0303	'Molybdopterin
HYN46_09690	COG0424	maF-like protein
HYN46_09700	COG1792	Involved in formation and maintenance of cell shape
HYN46_09705	COG1077	Cell shape determining protein MreB Mrl
HYN46_09710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYN46_09715	COG0154	amidase activity
HYN46_09720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYN46_09730	COG0737	Belongs to the 5'-nucleotidase family
HYN46_09735	COG0584	glycerophosphoryl diester phosphodiesterase
HYN46_09755	COG0438	transferase activity, transferring glycosyl groups
HYN46_09770	COG0463	Glycosyl transferase, family 2
HYN46_09775	COG0726	polysaccharide deacetylase
HYN46_09795	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HYN46_09800	COG0346	lactoylglutathione lyase activity
HYN46_09805	COG0681	Belongs to the peptidase S26 family
HYN46_09815	COG0243	molybdopterin cofactor binding
HYN46_09865	COG0137	argininosuccinate synthase activity
HYN46_09870	COG2203	Gaf domain
HYN46_09870	COG3706	GGDEF domain
HYN46_09870	COG4251	negative regulation of phosphorylation
HYN46_09870	COG5001	Diguanylate cyclase
HYN46_09885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYN46_09890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYN46_09925	COG0251	oxidation-reduction process
HYN46_09945	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HYN46_09950	COG0330	HflC and HflK could
HYN46_09960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYN46_09965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYN46_09980	COG1960	acyl-CoA dehydrogenase activity
HYN46_09985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYN46_10000	COG3384	dioxygenase
HYN46_10010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYN46_10015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYN46_10020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN46_10025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN46_10035	COG0180	Tryptophanyl-tRNA synthetase
HYN46_10040	COG0326	Molecular chaperone. Has ATPase activity
HYN46_10050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYN46_10075	COG1280	lysine exporter protein (LysE YggA)
HYN46_10095	COG0439	Biotin carboxylase
HYN46_10105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HYN46_10115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_10120	COG1116	anion transmembrane transporter activity
HYN46_10125	COG0864	Transcriptional regulator
HYN46_10130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN46_10160	COG4235	cytochrome complex assembly
HYN46_10160	COG3088	subunit of a heme lyase
HYN46_10170	COG1138	Cytochrome C-type biogenesis protein
HYN46_10185	COG0768	penicillin binding
HYN46_10190	COG0742	ribosomal rna small subunit methyltransferase
HYN46_10195	COG3384	dioxygenase
HYN46_10215	COG0529	Catalyzes the synthesis of activated sulfate
HYN46_10240	COG0505	Belongs to the CarA family
HYN46_10245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYN46_10255	COG2353	YceI-like domain
HYN46_10265	COG3038	cytochrome b561
HYN46_10295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYN46_10300	COG0210	DNA helicase
HYN46_10315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYN46_10325	COG4302	ethanolamine ammonia-lyase activity
HYN46_10330	COG4303	Ethanolamine ammonia lyase large subunit
HYN46_10335	COG0531	amino acid
HYN46_10355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYN46_10365	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYN46_10370	COG1960	acyl-CoA dehydrogenase activity
HYN46_10385	COG1902	pentaerythritol trinitrate reductase activity
HYN46_10390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYN46_10390	COG2169	Transcriptional regulator
HYN46_10395	COG3145	DNA-N1-methyladenine dioxygenase activity
HYN46_10410	COG0202	RNA polymerase activity
HYN46_10415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYN46_10425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYN46_10440	COG0200	Binds to the 23S rRNA
HYN46_10465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYN46_10470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYN46_10480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYN46_10485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYN46_10500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYN46_10505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYN46_10510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYN46_10520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYN46_10525	COG0089	rRNA binding
HYN46_10530	COG0088	Forms part of the polypeptide exit tunnel
HYN46_10540	COG0051	transcription antitermination factor activity, RNA binding
HYN46_10545	COG0505	Belongs to the CarA family
HYN46_10550	COG0534	Mate efflux family protein
HYN46_10555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYN46_10560	COG3719	Belongs to the RNase T2 family
HYN46_10595	COG0252	asparaginase activity
HYN46_10605	COG0814	amino acid
HYN46_10625	COG0473	3-isopropylmalate dehydrogenase activity
HYN46_10640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYN46_10645	COG0583	DNA-binding transcription factor activity
HYN46_10680	COG0582	viral genome integration into host DNA
HYN46_10760	COG2223	nitrite transmembrane transporter activity
HYN46_10765	COG3706	GGDEF domain
HYN46_10770	COG4221	oxidoreductase activity
HYN46_10810	COG0588	phosphoglycerate mutase activity
HYN46_10825	COG1960	acyl-CoA dehydrogenase activity
HYN46_10855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYN46_10915	COG1702	phosphate starvation-inducible protein PhoH
HYN46_10935	COG2814	Major facilitator Superfamily
HYN46_10950	COG1454	alcohol dehydrogenase
HYN46_10980	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYN46_10985	COG0343	queuine tRNA-ribosyltransferase activity
HYN46_10990	COG0308	aminopeptidase N
HYN46_10995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYN46_11005	COG2814	Major facilitator Superfamily
HYN46_11010	COG0583	DNA-binding transcription factor activity
HYN46_11015	COG0798	PFAM Bile acid sodium symporter
HYN46_11025	COG0640	Transcriptional regulator
HYN46_11030	COG1271	oxidase subunit
HYN46_11035	COG1294	oxidase, subunit
HYN46_11040	COG1862	Preprotein translocase
HYN46_11060	COG0501	Belongs to the peptidase M48B family
HYN46_11070	COG4774	siderophore transport
HYN46_11075	COG1187	pseudouridine synthase activity
HYN46_11095	COG1464	Belongs to the NlpA lipoprotein family
HYN46_11100	COG2011	ABC-type metal ion transport system permease component
HYN46_11105	COG3540	Alkaline phosphatase
HYN46_11120	COG0039	L-malate dehydrogenase activity
HYN46_11130	COG5510	response to toxic substance
HYN46_11135	COG0514	ATP-dependent DNA helicase (RecQ)
HYN46_11145	COG2501	S4 domain
HYN46_11165	COG2201	protein-glutamate methylesterase activity
HYN46_11170	COG0643	Histidine kinase
HYN46_11170	COG0784	Response regulator, receiver
HYN46_11170	COG2198	Histidine kinase
HYN46_11185	COG0840	transmembrane signaling receptor activity
HYN46_11210	COG0492	ferredoxin-NADP+ reductase activity
HYN46_11215	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HYN46_11220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HYN46_11225	COG0456	acetyltransferase
HYN46_11240	COG0222	ribosome binding
HYN46_11245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYN46_11255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYN46_11265	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYN46_11330	COG0629	single-stranded DNA binding
HYN46_11340	COG1285	pathogenesis
HYN46_11370	COG0488	(ABC) transporter
HYN46_11375	COG4221	oxidoreductase activity
HYN46_11380	COG2183	response to ionizing radiation
HYN46_11420	COG1215	transferase activity, transferring glycosyl groups
HYN46_11440	COG5295	Hep Hag repeat protein
HYN46_11465	COG1192	Involved in chromosome partitioning
HYN46_11475	COG0271	Belongs to the BolA IbaG family
HYN46_11490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYN46_11500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYN46_11530	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYN46_11540	COG2223	nitrite transmembrane transporter activity
HYN46_11545	COG2223	nitrite transmembrane transporter activity
HYN46_11565	COG2072	flavoprotein involved in K transport
HYN46_11570	COG3135	benzoate transporter
HYN46_11580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYN46_11600	COG2814	Major facilitator Superfamily
HYN46_11605	COG0443	Heat shock 70 kDa protein
HYN46_11615	COG0657	acetylesterase activity
HYN46_11640	COG0318	PFAM AMP-dependent synthetase and ligase
HYN46_11650	COG0758	DNA mediated transformation
HYN46_11655	COG1652	LysM domain
HYN46_11670	COG0288	reversible hydration of carbon dioxide
HYN46_11675	COG0019	diaminopimelate decarboxylase activity
HYN46_11695	COG0156	8-amino-7-oxononanoate synthase activity
HYN46_11700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYN46_11725	COG1064	alcohol dehydrogenase
HYN46_11735	COG0831	urea catabolic process
HYN46_11740	COG0832	Belongs to the urease beta subunit family
HYN46_11745	COG0804	urea catabolic process
HYN46_11760	COG0830	nickel cation binding
HYN46_11775	COG0477	Major facilitator Superfamily
HYN46_11805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYN46_11810	COG1733	regulation of RNA biosynthetic process
HYN46_11815	COG2076	Multidrug Resistance protein
HYN46_11830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYN46_11835	COG0251	oxidation-reduction process
HYN46_11840	COG0259	pyridoxamine-phosphate oxidase activity
HYN46_11925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYN46_11965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYN46_11970	COG3845	ABC transporter
HYN46_11975	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYN46_11980	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYN46_11990	COG0402	S-adenosylhomocysteine deaminase activity
HYN46_11995	COG1301	dicarboxylic acid transport
HYN46_12010	COG4266	Belongs to the allantoicase family
HYN46_12015	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HYN46_12020	COG2351	hydroxyisourate hydrolase activity
HYN46_12030	COG3648	Uricase
HYN46_12030	COG3195	allantoin biosynthetic process
HYN46_12040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYN46_12050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYN46_12055	COG3956	TIGRFAM MazG family protein
HYN46_12060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYN46_12065	COG0617	tRNA 3'-terminal CCA addition
HYN46_12070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYN46_12075	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYN46_12085	COG1660	Displays ATPase and GTPase activities
HYN46_12110	COG3307	-O-antigen
HYN46_12115	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYN46_12120	COG0740	serine-type endopeptidase activity
HYN46_12130	COG0628	permease
HYN46_12135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYN46_12150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HYN46_12165	COG0121	glutamine amidotransferase
HYN46_12170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYN46_12185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYN46_12195	COG1476	TRANSCRIPTIONal
HYN46_12200	COG1538	Outer membrane efflux protein
HYN46_12210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN46_12215	COG1872	DUF167
HYN46_12230	COG0037	tRNA processing
HYN46_12240	COG0248	Ppx GppA phosphatase
HYN46_12260	COG0546	phosphoglycolate phosphatase activity
HYN46_12265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYN46_12275	COG1666	GTP binding
HYN46_12305	COG2824	Alkylphosphonate utilization operon protein PhnA
HYN46_12330	COG0564	pseudouridine synthase activity
HYN46_12340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYN46_12355	COG0372	Belongs to the citrate synthase family
HYN46_12375	COG0745	RESPONSE REGULATOR receiver
HYN46_12380	COG2205	protein histidine kinase activity
HYN46_12390	COG0745	RESPONSE REGULATOR receiver
HYN46_12395	COG2205	protein histidine kinase activity
HYN46_12405	COG0583	DNA-binding transcription factor activity
HYN46_12415	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN46_12435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN46_12440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYN46_12450	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HYN46_12460	COG0649	NAD binding
HYN46_12460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN46_12465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN46_12475	COG2321	neutral zinc metallopeptidase
HYN46_12485	COG0513	Belongs to the DEAD box helicase family
HYN46_12515	COG1127	ABC transporter
HYN46_12520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYN46_12525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HYN46_12555	COG0598	Magnesium transport protein CorA
HYN46_12560	COG1040	competence protein
HYN46_12600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYN46_12605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYN46_12615	COG0408	coproporphyrinogen oxidase activity
HYN46_12620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYN46_12635	COG0697	spore germination
HYN46_12640	COG1960	acyl-CoA dehydrogenase activity
HYN46_12650	COG2267	carboxylic ester hydrolase activity
HYN46_12655	COG1983	PspC domain protein
HYN46_12660	COG3590	peptidase
HYN46_12670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYN46_12700	COG0494	nUDIX hydrolase
HYN46_12715	COG3621	Patatin-like phospholipase
HYN46_12725	COG0477	Major facilitator Superfamily
HYN46_12730	COG0477	Major facilitator Superfamily
HYN46_12755	COG0546	phosphoglycolate phosphatase activity
HYN46_12765	COG1530	ribonuclease E activity
HYN46_12770	COG0318	PFAM AMP-dependent synthetase and ligase
HYN46_12825	COG3795	YCII-related domain
HYN46_12830	COG4941	Belongs to the sigma-70 factor family
HYN46_12865	COG4771	TonB-dependent receptor
HYN46_12890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_12895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_12910	COG1132	(ABC) transporter
HYN46_12915	COG1132	(ABC) transporter
HYN46_12930	COG1116	anion transmembrane transporter activity
HYN46_12945	COG3604	Transcriptional regulator
HYN46_12970	COG2144	transferase activity, transferring acyl groups
HYN46_12980	COG2072	flavoprotein involved in K transport
HYN46_12995	COG0129	dihydroxy-acid dehydratase activity
HYN46_13005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYN46_13020	COG0300	oxidoreductase activity
HYN46_13030	COG0010	Belongs to the arginase family
HYN46_13035	COG3023	N-Acetylmuramoyl-L-alanine amidase
HYN46_13055	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYN46_13065	COG0596	Alpha beta hydrolase
HYN46_13070	COG0778	Nitroreductase
HYN46_13115	COG0194	GDP metabolic process
HYN46_13120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYN46_13130	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYN46_13175	COG1758	RNA polymerase activity
HYN46_13195	COG2095	MarC family integral membrane protein
HYN46_13200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYN46_13205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYN46_13210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HYN46_13220	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HYN46_13225	COG4208	sulfate ABC transporter
HYN46_13230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HYN46_13235	COG0583	DNA-binding transcription factor activity
HYN46_13255	COG3511	phospholipase C
HYN46_13275	COG1074	ATP-dependent DNA helicase activity
HYN46_13280	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HYN46_13305	COG2226	methyltransferase
HYN46_13315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYN46_13320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYN46_13330	COG1970	mechanosensitive ion channel activity
HYN46_13335	COG1217	gtp-binding protein TYPA
HYN46_13350	COG0183	Belongs to the thiolase family
HYN46_13360	COG1397	ADP-ribosylglycohydrolase
HYN46_13365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYN46_13370	COG0084	hydrolase, TatD family'
HYN46_13390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYN46_13415	COG1335	isochorismatase
HYN46_13425	COG2378	regulation of single-species biofilm formation
HYN46_13490	COG4122	O-methyltransferase activity
HYN46_13525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HYN46_13585	COG2375	cellular response to nickel ion
HYN46_13660	COG0730	response to heat
HYN46_13665	COG0583	DNA-binding transcription factor activity
HYN46_13690	COG5492	domain, Protein
HYN46_13690	COG4932	domain protein
HYN46_13730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYN46_13735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYN46_13745	COG1335	isochorismatase
HYN46_13755	COG1335	isochorismatase
HYN46_13785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYN46_13805	COG0583	DNA-binding transcription factor activity
HYN46_13810	COG1942	4-Oxalocrotonate Tautomerase
HYN46_13830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYN46_13835	COG1595	DNA-templated transcription, initiation
HYN46_13840	COG3511	phospholipase C
HYN46_13910	COG3772	lysozyme
HYN46_14260	COG2258	MOSC domain
HYN46_14265	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_14270	COG0583	DNA-binding transcription factor activity
HYN46_14340	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_14375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN46_14405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYN46_14415	COG4771	TonB-dependent receptor
HYN46_14475	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYN46_14495	COG0583	DNA-binding transcription factor activity
HYN46_14505	COG3268	Saccharopine dehydrogenase
HYN46_14535	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN46_14540	COG0025	NhaP-type Na H and K H
HYN46_14560	COG2132	Multicopper oxidase
HYN46_14585	COG0583	DNA-binding transcription factor activity
HYN46_14625	COG0667	Aldo Keto reductase
HYN46_14630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYN46_14635	COG1126	abc transporter atp-binding protein
HYN46_14645	COG0765	amino acid transport
HYN46_14655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYN46_14660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYN46_14670	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_14700	COG3291	Pkd domain containing protein
HYN46_14750	COG0667	Aldo Keto reductase
HYN46_14755	COG2205	protein histidine kinase activity
HYN46_14760	COG0745	RESPONSE REGULATOR receiver
HYN46_14770	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_14785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYN46_14785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYN46_14795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYN46_14815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HYN46_14895	COG1063	alcohol dehydrogenase
HYN46_14900	COG0697	spore germination
HYN46_14905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYN46_14915	COG0307	riboflavin synthase, alpha
HYN46_14920	COG1605	Chorismate mutase
HYN46_14925	COG0583	DNA-binding transcription factor activity
HYN46_14930	COG0243	molybdopterin cofactor binding
HYN46_14935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYN46_14950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYN46_14955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYN46_14970	COG3209	COG3209 Rhs family protein
HYN46_15025	COG1609	Transcriptional regulator
HYN46_15025	COG2207	Transcriptional regulator
HYN46_15045	COG2072	flavoprotein involved in K transport
HYN46_15080	COG0793	Belongs to the peptidase S41A family
HYN46_15110	COG1846	Transcriptional regulator
HYN46_15115	COG1538	Outer membrane efflux protein
HYN46_15120	COG1566	PFAM secretion protein HlyD family protein
HYN46_15125	COG2814	Major facilitator Superfamily
HYN46_15155	COG2207	Transcriptional regulator
HYN46_15160	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYN46_15210	COG3047	cAMP biosynthetic process
HYN46_15225	COG1294	oxidase, subunit
HYN46_15240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYN46_15245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN46_15260	COG1309	transcriptional regulator
HYN46_15280	COG2885	chlorophyll binding
HYN46_15300	COG1960	acyl-CoA dehydrogenase activity
HYN46_15305	COG1253	flavin adenine dinucleotide binding
HYN46_15315	COG1285	pathogenesis
HYN46_15335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HYN46_15350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYN46_15355	COG0534	Mate efflux family protein
HYN46_15365	COG1309	transcriptional regulator
HYN46_15375	COG2205	protein histidine kinase activity
HYN46_15390	COG0604	alcohol dehydrogenase
HYN46_15390	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_15390	COG3321	synthase
HYN46_15420	COG0583	DNA-binding transcription factor activity
HYN46_15470	COG3383	formate dehydrogenase (NAD+) activity
HYN46_15495	COG2207	Transcriptional regulator
HYN46_15520	COG3237	CsbD-like
HYN46_15540	COG1968	undecaprenyl-diphosphatase activity
HYN46_15565	COG0183	Belongs to the thiolase family
HYN46_15570	COG0657	acetylesterase activity
HYN46_15570	COG2755	lipolytic protein G-D-S-L family
HYN46_15585	COG2814	Major facilitator Superfamily
HYN46_15590	COG4264	IucA IucC family
HYN46_15635	COG0811	peptide transport
HYN46_15650	COG0430	RNA-3'-phosphate cyclase activity
HYN46_15655	COG1690	Belongs to the RtcB family
HYN46_15660	COG4650	regulator
HYN46_15670	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYN46_15695	COG4221	oxidoreductase activity
HYN46_15715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN46_15730	COG1309	transcriptional regulator
HYN46_15745	COG2951	lytic endotransglycosylase activity
HYN46_15755	COG3012	SEC-C Motif Domain Protein
HYN46_15760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYN46_15775	COG1301	dicarboxylic acid transport
HYN46_15785	COG1280	lysine exporter protein (LysE YggA)
HYN46_15805	COG0506	proline dehydrogenase activity
HYN46_15805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HYN46_15805	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HYN46_15815	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_15825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYN46_15825	COG0519	Catalyzes the synthesis of GMP from XMP
HYN46_15830	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HYN46_15855	COG3116	cell division
HYN46_15870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYN46_15875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYN46_15885	COG2197	response regulator
HYN46_15890	COG1686	Belongs to the peptidase S11 family
HYN46_15895	COG2918	glutathione biosynthetic process
HYN46_15915	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HYN46_15960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYN46_15965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYN46_15975	COG1534	Rna-binding protein
HYN46_15980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYN46_16000	COG4221	oxidoreductase activity
HYN46_16015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HYN46_16020	COG0583	DNA-binding transcription factor activity
HYN46_16035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HYN46_16040	COG4676	Protein conserved in bacteria
HYN46_16045	COG0204	Acyl-transferase
HYN46_16085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYN46_16090	COG4676	Protein conserved in bacteria
HYN46_16095	COG5445	Predicted secreted protein (DUF2300)
HYN46_16100	COG2373	Large extracellular alpha-helical protein
HYN46_16110	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HYN46_16135	COG0726	polysaccharide deacetylase
HYN46_16135	COG1649	PFAM Uncharacterised BCR, COG1649
HYN46_16140	COG1215	transferase activity, transferring glycosyl groups
HYN46_16160	COG0318	PFAM AMP-dependent synthetase and ligase
HYN46_16210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYN46_16220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYN46_16245	COG0735	belongs to the Fur family
HYN46_16250	COG1121	(ABC) transporter
HYN46_16255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYN46_16285	COG1028	Short-chain dehydrogenase reductase Sdr
HYN46_16290	COG4574	serine-type endopeptidase inhibitor activity
HYN46_16300	COG1194	a g-specific adenine glycosylase
HYN46_16315	COG1088	dTDP-glucose 4,6-dehydratase activity
HYN46_16320	COG1091	dTDP-4-dehydrorhamnose reductase activity
HYN46_16345	COG0166	Belongs to the GPI family
HYN46_16355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYN46_16365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYN46_16370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYN46_16380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HYN46_16380	COG0546	phosphoglycolate phosphatase activity
HYN46_16385	COG0277	FAD linked oxidase domain protein
HYN46_16390	COG0300	oxidoreductase activity
HYN46_16435	COG1024	Enoyl-CoA hydratase
HYN46_16435	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYN46_16440	COG4221	oxidoreductase activity
HYN46_16470	COG2837	iron assimilation
HYN46_16495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYN46_16500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HYN46_16540	COG0488	(ABC) transporter
HYN46_16545	COG4206	TonB-dependent receptor
HYN46_16555	COG0187	DNA topoisomerase II activity
HYN46_16565	COG0592	DNA-directed DNA polymerase activity
HYN46_16590	COG0706	membrane insertase activity
HYN46_16630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYN46_16645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYN46_16650	COG2188	Transcriptional regulator
HYN46_16660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYN46_16670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYN46_16690	COG0412	Dienelactone hydrolase
HYN46_16695	COG2072	flavoprotein involved in K transport
HYN46_16725	COG0195	Participates in both transcription termination and antitermination
HYN46_16745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYN46_16750	COG0149	triose-phosphate isomerase activity
HYN46_16775	COG0237	dephospho-CoA kinase activity
HYN46_16825	COG0592	DNA-directed DNA polymerase activity
HYN46_17020	COG3772	lysozyme
HYN46_17070	COG0592	DNA-directed DNA polymerase activity