locus-tag	class	description
HME7025_00003	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HME7025_00013	COG1216	Glycosyl transferase, family 2
HME7025_00013	COG0463	Glycosyl transferase, family 2
HME7025_00019	COG1733	regulation of RNA biosynthetic process
HME7025_00026	COG0700	Nucleoside recognition
HME7025_00029	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HME7025_00030	COG1022	Amp-dependent synthetase and ligase
HME7025_00034	COG0445	tRNA wobble uridine modification
HME7025_00035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HME7025_00036	COG0792	nuclease activity
HME7025_00037	COG0321	lipoyl(octanoyl) transferase activity
HME7025_00041	COG0038	chloride channel
HME7025_00042	COG0513	Belongs to the DEAD box helicase family
HME7025_00045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HME7025_00046	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HME7025_00049	COG1381	Involved in DNA repair and RecF pathway recombination
HME7025_00052	COG0113	porphobilinogen synthase activity
HME7025_00053	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HME7025_00054	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HME7025_00055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HME7025_00058	COG0149	triose-phosphate isomerase activity
HME7025_00059	COG1472	Belongs to the glycosyl hydrolase 3 family
HME7025_00060	COG1090	epimerase
HME7025_00061	COG1611	Belongs to the LOG family
HME7025_00062	COG2885	chlorophyll binding
HME7025_00065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HME7025_00066	COG3620	sequence-specific DNA binding
HME7025_00097	COG1876	peptidase activity
HME7025_00110	COG1522	sequence-specific DNA binding
HME7025_00111	COG0343	queuine tRNA-ribosyltransferase activity
HME7025_00118	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HME7025_00119	COG4989	oxidoreductase activity
HME7025_00120	COG0557	exoribonuclease II activity
HME7025_00122	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HME7025_00123	COG2045	Belongs to the ComB family
HME7025_00128	COG0463	Glycosyl transferase, family 2
HME7025_00129	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_00139	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HME7025_00140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HME7025_00158	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HME7025_00159	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HME7025_00163	COG4771	TonB-dependent receptor
HME7025_00177	COG3394	polysaccharide catabolic process
HME7025_00179	COG0667	Aldo Keto reductase
HME7025_00180	COG0154	amidase activity
HME7025_00181	COG5285	phytanoyl-CoA dioxygenase
HME7025_00182	COG0673	inositol 2-dehydrogenase activity
HME7025_00183	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HME7025_00189	COG3119	arylsulfatase activity
HME7025_00190	COG3119	arylsulfatase activity
HME7025_00190	COG3408	Glycogen debranching enzyme
HME7025_00194	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HME7025_00204	COG4771	TonB-dependent receptor
HME7025_00209	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HME7025_00210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HME7025_00211	COG0556	nucleotide-excision repair
HME7025_00214	COG3956	TIGRFAM MazG family protein
HME7025_00217	COG0673	inositol 2-dehydrogenase activity
HME7025_00223	COG0405	Gamma-glutamyltransferase
HME7025_00224	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HME7025_00225	COG0436	Aminotransferase
HME7025_00229	COG0140	phosphoribosyl-ATP diphosphatase activity
HME7025_00229	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HME7025_00230	COG0107	imidazoleglycerol-phosphate synthase activity
HME7025_00231	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HME7025_00234	COG0513	Belongs to the DEAD box helicase family
HME7025_00238	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HME7025_00241	COG0148	phosphopyruvate hydratase activity
HME7025_00243	COG0667	Aldo Keto reductase
HME7025_00251	COG1215	transferase activity, transferring glycosyl groups
HME7025_00252	COG0357	Ribosomal RNA small subunit methyltransferase G
HME7025_00254	COG0306	phosphate transporter
HME7025_00256	COG1530	ribonuclease E activity
HME7025_00260	COG0629	single-stranded DNA binding
HME7025_00261	COG4535	Mg2 and Co2 transporter CorC
HME7025_00274	COG1785	Belongs to the alkaline phosphatase family
HME7025_00275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HME7025_00277	COG4771	TonB-dependent receptor
HME7025_00282	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HME7025_00283	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HME7025_00284	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HME7025_00285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HME7025_00287	COG2271	Major facilitator Superfamily
HME7025_00288	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HME7025_00290	COG1904	glucuronate isomerase
HME7025_00291	COG0246	Mannitol dehydrogenase
HME7025_00297	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HME7025_00298	COG0085	RNA polymerase activity
HME7025_00300	COG1012	belongs to the aldehyde dehydrogenase family
HME7025_00310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HME7025_00311	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HME7025_00314	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HME7025_00315	COG0222	ribosome binding
HME7025_00316	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HME7025_00317	COG0081	regulation of translation
HME7025_00318	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HME7025_00331	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HME7025_00333	COG2322	membrane
HME7025_00336	COG1845	cytochrome c oxidase, subunit III
HME7025_00337	COG1845	cytochrome c oxidase, subunit III
HME7025_00338	COG0109	protoheme IX farnesyltransferase activity
HME7025_00340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HME7025_00341	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HME7025_00346	COG0437	4 iron, 4 sulfur cluster binding
HME7025_00350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_00351	COG1473	amidohydrolase
HME7025_00355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HME7025_00356	COG5002	protein histidine kinase activity
HME7025_00358	COG0346	lactoylglutathione lyase activity
HME7025_00359	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HME7025_00360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HME7025_00360	COG0512	Glutamine amidotransferase of anthranilate synthase
HME7025_00361	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HME7025_00362	COG0134	indole-3-glycerol-phosphate synthase activity
HME7025_00363	COG0135	phosphoribosylanthranilate isomerase activity
HME7025_00364	COG0133	tryptophan synthase activity
HME7025_00365	COG0159	tryptophan synthase activity
HME7025_00366	COG0335	large ribosomal subunit rRNA binding
HME7025_00368	COG1136	(ABC) transporter
HME7025_00371	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HME7025_00372	COG1040	competence protein
HME7025_00373	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HME7025_00373	COG0515	serine threonine protein kinase
HME7025_00374	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HME7025_00377	COG0861	Integral membrane protein TerC family
HME7025_00385	COG4628	conserved protein (DUF2132)
HME7025_00386	COG0488	(ABC) transporter
HME7025_00387	COG0805	protein transport
HME7025_00388	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HME7025_00393	COG0656	L-ascorbic acid biosynthetic process
HME7025_00395	COG1649	PFAM Uncharacterised BCR, COG1649
HME7025_00396	COG0745	RESPONSE REGULATOR receiver
HME7025_00397	COG0628	permease
HME7025_00398	COG3279	Response regulator of the LytR AlgR family
HME7025_00399	COG3275	phosphorelay sensor kinase activity
HME7025_00400	COG0406	alpha-ribazole phosphatase activity
HME7025_00401	COG2050	protein possibly involved in aromatic compounds catabolism
HME7025_00404	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HME7025_00405	COG0431	NADPH-dependent FMN reductase
HME7025_00407	COG1253	flavin adenine dinucleotide binding
HME7025_00414	COG1918	ferrous iron import across plasma membrane
HME7025_00414	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HME7025_00418	COG1809	phosphosulfolactate synthase activity
HME7025_00419	COG0586	Pfam SNARE associated Golgi protein
HME7025_00420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HME7025_00421	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HME7025_00423	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HME7025_00428	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HME7025_00429	COG0590	tRNA wobble adenosine to inosine editing
HME7025_00430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HME7025_00436	COG0662	Cupin 2, conserved barrel domain protein
HME7025_00436	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HME7025_00437	COG4771	TonB-dependent receptor
HME7025_00438	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HME7025_00443	COG0247	lactate metabolic process
HME7025_00443	COG2181	nitrate reductase activity
HME7025_00445	COG1956	GAF domain-containing protein
HME7025_00446	COG2318	DinB family
HME7025_00447	COG0688	phosphatidylethanolamine metabolic process
HME7025_00452	COG0314	molybdopterin synthase activity
HME7025_00453	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HME7025_00460	COG1538	Outer membrane efflux protein
HME7025_00461	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HME7025_00462	COG0438	transferase activity, transferring glycosyl groups
HME7025_00464	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HME7025_00464	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HME7025_00465	COG1678	Uncharacterized ACR, COG1678
HME7025_00466	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HME7025_00468	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_00469	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_00472	COG1215	transferase activity, transferring glycosyl groups
HME7025_00473	COG1132	(ABC) transporter
HME7025_00474	COG0436	Aminotransferase
HME7025_00475	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HME7025_00477	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HME7025_00478	COG0275	rRNA processing
HME7025_00480	COG0768	penicillin binding
HME7025_00481	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HME7025_00482	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HME7025_00484	COG1228	amidohydrolase
HME7025_00486	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HME7025_00487	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HME7025_00490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HME7025_00491	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HME7025_00495	COG0360	Binds together with S18 to 16S ribosomal RNA
HME7025_00496	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HME7025_00497	COG0359	binds to the 23S rRNA
HME7025_00498	COG0538	isocitrate dehydrogenase activity
HME7025_00499	COG0788	formyltetrahydrofolate deformylase activity
HME7025_00500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HME7025_00503	COG0242	peptide deformylase activity
HME7025_00504	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HME7025_00505	COG0616	signal peptide processing
HME7025_00506	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HME7025_00509	COG1418	mRNA catabolic process
HME7025_00513	COG3279	Response regulator of the LytR AlgR family
HME7025_00514	COG0745	RESPONSE REGULATOR receiver
HME7025_00514	COG2972	Histidine kinase
HME7025_00518	COG0022	dehydrogenase e1 component
HME7025_00521	COG0713	ATP synthesis coupled electron transport
HME7025_00522	COG0322	excinuclease ABC activity
HME7025_00523	COG1629	transport
HME7025_00524	COG0702	epimerase
HME7025_00527	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HME7025_00530	COG0768	penicillin binding
HME7025_00531	COG0772	Belongs to the SEDS family
HME7025_00532	COG0477	Major facilitator Superfamily
HME7025_00534	COG2363	Small membrane protein
HME7025_00535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HME7025_00536	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HME7025_00537	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HME7025_00538	COG0356	it plays a direct role in the translocation of protons across the membrane
HME7025_00540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HME7025_00541	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_00542	COG2211	Major facilitator Superfamily
HME7025_00546	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HME7025_00547	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HME7025_00548	COG4771	TonB-dependent receptor
HME7025_00555	COG1960	acyl-CoA dehydrogenase activity
HME7025_00557	COG0287	Prephenate dehydrogenase
HME7025_00561	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HME7025_00562	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_00563	COG0429	hydrolase of the alpha beta-hydrolase fold
HME7025_00564	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HME7025_00565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HME7025_00566	COG0673	inositol 2-dehydrogenase activity
HME7025_00570	COG0217	transcriptional regulatory protein
HME7025_00575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HME7025_00576	COG4771	TonB-dependent receptor
HME7025_00579	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HME7025_00581	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HME7025_00582	COG2816	NAD+ diphosphatase activity
HME7025_00585	COG1846	Transcriptional regulator
HME7025_00585	COG1940	carbohydrate kinase activity
HME7025_00589	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HME7025_00591	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HME7025_00598	COG3386	PFAM SMP-30 Gluconolaconase
HME7025_00601	COG2890	protein-(glutamine-N5) methyltransferase activity
HME7025_00605	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HME7025_00608	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HME7025_00609	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HME7025_00611	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HME7025_00612	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HME7025_00613	COG0052	Belongs to the universal ribosomal protein uS2 family
HME7025_00614	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HME7025_00615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HME7025_00616	COG0439	Biotin carboxylase
HME7025_00617	COG0511	ligase activity, forming carbon-carbon bonds
HME7025_00618	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HME7025_00619	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HME7025_00620	COG0416	fatty acid biosynthetic process
HME7025_00621	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HME7025_00624	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HME7025_00625	COG0105	UTP biosynthetic process
HME7025_00627	COG0545	Peptidyl-prolyl cis-trans isomerase
HME7025_00630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HME7025_00632	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HME7025_00634	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HME7025_00637	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HME7025_00638	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HME7025_00639	COG0517	IMP dehydrogenase activity
HME7025_00639	COG0516	GMP reductase activity
HME7025_00642	COG0673	inositol 2-dehydrogenase activity
HME7025_00643	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_00644	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_00646	COG0649	NAD binding
HME7025_00647	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HME7025_00650	COG1034	ATP synthesis coupled electron transport
HME7025_00651	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HME7025_00652	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_00653	COG0839	Belongs to the complex I subunit 6 family
HME7025_00656	COG0745	RESPONSE REGULATOR receiver
HME7025_00656	COG2972	Histidine kinase
HME7025_00657	COG3279	Response regulator of the LytR AlgR family
HME7025_00661	COG0438	transferase activity, transferring glycosyl groups
HME7025_00665	COG0438	transferase activity, transferring glycosyl groups
HME7025_00666	COG1088	dTDP-glucose 4,6-dehydratase activity
HME7025_00669	COG0612	Peptidase, M16
HME7025_00670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HME7025_00671	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HME7025_00673	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HME7025_00675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HME7025_00681	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HME7025_00692	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HME7025_00693	COG0489	protein tyrosine kinase activity
HME7025_00697	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HME7025_00700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HME7025_00701	COG0531	amino acid
HME7025_00702	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HME7025_00703	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HME7025_00705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HME7025_00716	COG0006	proline dipeptidase activity
HME7025_00722	COG1309	transcriptional regulator
HME7025_00725	COG3940	Belongs to the glycosyl hydrolase 43 family
HME7025_00728	COG4989	oxidoreductase activity
HME7025_00730	COG0494	nUDIX hydrolase
HME7025_00731	COG2989	Protein conserved in bacteria
HME7025_00737	COG1082	Xylose isomerase domain protein TIM barrel
HME7025_00743	COG2382	esterase
HME7025_00745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HME7025_00746	COG3119	arylsulfatase activity
HME7025_00752	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HME7025_00755	COG2133	pyrroloquinoline quinone binding
HME7025_00760	COG1104	cysteine desulfurase activity
HME7025_00765	COG4783	chaperone-mediated protein folding
HME7025_00773	COG1629	transport
HME7025_00781	COG2081	HI0933 family
HME7025_00786	COG0667	Aldo Keto reductase
HME7025_00787	COG1063	alcohol dehydrogenase
HME7025_00788	COG1082	Xylose isomerase domain protein TIM barrel
HME7025_00789	COG3254	rhamnose metabolic process
HME7025_00791	COG0673	inositol 2-dehydrogenase activity
HME7025_00792	COG0584	glycerophosphoryl diester phosphodiesterase
HME7025_00794	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_00797	COG0667	Aldo Keto reductase
HME7025_00801	COG1607	acyl-coa hydrolase
HME7025_00802	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HME7025_00802	COG1648	precorrin-2 dehydrogenase activity
HME7025_00803	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HME7025_00806	COG2223	nitrite transmembrane transporter activity
HME7025_00807	COG0243	molybdopterin cofactor binding
HME7025_00809	COG1773	rubredoxin
HME7025_00810	COG0746	molybdenum cofactor guanylyltransferase activity
HME7025_00812	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HME7025_00816	COG1404	Belongs to the peptidase S8 family
HME7025_00821	COG0415	Belongs to the DNA photolyase family
HME7025_00822	COG3046	protein related to deoxyribodipyrimidine photolyase
HME7025_00823	COG3507	Belongs to the glycosyl hydrolase 43 family
HME7025_00823	COG3693	PFAM glycoside hydrolase, family 10
HME7025_00823	COG2382	esterase
HME7025_00824	COG3119	arylsulfatase activity
HME7025_00826	COG0861	Integral membrane protein TerC family
HME7025_00828	COG0592	DNA-directed DNA polymerase activity
HME7025_00830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HME7025_00831	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HME7025_00832	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HME7025_00833	COG0137	argininosuccinate synthase activity
HME7025_00835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HME7025_00837	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HME7025_00844	COG0653	protein targeting
HME7025_00850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HME7025_00851	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HME7025_00854	COG0513	Belongs to the DEAD box helicase family
HME7025_00855	COG0783	Belongs to the Dps family
HME7025_00857	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HME7025_00859	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HME7025_00861	COG0251	oxidation-reduction process
HME7025_00862	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HME7025_00862	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HME7025_00864	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HME7025_00865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HME7025_00867	COG0022	dehydrogenase e1 component
HME7025_00867	COG0508	dehydrogenase complex catalyzes the overall conversion of
HME7025_00868	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HME7025_00869	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HME7025_00870	COG1278	Cold shock
HME7025_00873	COG0531	amino acid
HME7025_00875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HME7025_00875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HME7025_00877	COG0297	glycogen (starch) synthase activity
HME7025_00879	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HME7025_00881	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HME7025_00881	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HME7025_00885	COG1127	ABC transporter
HME7025_00886	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HME7025_00890	COG0571	ribonuclease III activity
HME7025_00891	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HME7025_00892	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HME7025_00893	COG1940	carbohydrate kinase activity
HME7025_00895	COG1435	thymidine kinase activity
HME7025_00897	COG1053	succinate dehydrogenase
HME7025_00902	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HME7025_00906	COG1629	transport
HME7025_00908	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HME7025_00908	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HME7025_00916	COG1902	pentaerythritol trinitrate reductase activity
HME7025_00917	COG1733	regulation of RNA biosynthetic process
HME7025_00918	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HME7025_00919	COG1104	cysteine desulfurase activity
HME7025_00920	COG0442	prolyl-tRNA aminoacylation
HME7025_00923	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HME7025_00926	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HME7025_00928	COG0521	Mo-molybdopterin cofactor biosynthetic process
HME7025_00929	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HME7025_00931	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HME7025_00932	COG3341	Caulimovirus viroplasmin
HME7025_00932	COG0328	RNA-DNA hybrid ribonuclease activity
HME7025_00933	COG2095	MarC family integral membrane protein
HME7025_00934	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HME7025_00935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HME7025_00936	COG4974	Belongs to the 'phage' integrase family
HME7025_00939	COG0802	atpase or kinase
HME7025_00940	COG0300	oxidoreductase activity
HME7025_00941	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HME7025_00945	COG0167	dihydroorotate dehydrogenase activity
HME7025_00946	COG1674	ftsk spoiiie
HME7025_00948	COG0047	phosphoribosylformylglycinamidine synthase activity
HME7025_00951	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HME7025_00954	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HME7025_00956	COG0730	response to heat
HME7025_00957	COG0495	leucyl-tRNA aminoacylation
HME7025_00958	COG3119	arylsulfatase activity
HME7025_00961	COG1082	Xylose isomerase domain protein TIM barrel
HME7025_00966	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HME7025_00971	COG1032	radical SAM domain protein
HME7025_00972	COG2824	Alkylphosphonate utilization operon protein PhnA
HME7025_00983	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HME7025_00984	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HME7025_00986	COG2096	Adenosyltransferase
HME7025_00987	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HME7025_00990	COG1022	Amp-dependent synthetase and ligase
HME7025_00992	COG0799	negative regulation of ribosome biogenesis
HME7025_00993	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HME7025_00995	COG1621	beta-fructofuranosidase activity
HME7025_00999	COG4152	abc transporter atp-binding protein
HME7025_01000	COG1668	transmembrane transport
HME7025_01002	COG2860	membrane
HME7025_01004	COG1393	Belongs to the ArsC family
HME7025_01005	COG0114	fumarate hydratase activity
HME7025_01007	COG0640	Transcriptional regulator
HME7025_01008	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HME7025_01009	COG0126	phosphoglycerate kinase activity
HME7025_01012	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HME7025_01014	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HME7025_01016	COG3118	belongs to the thioredoxin family
HME7025_01018	COG1162	GTPase activity
HME7025_01019	COG1940	carbohydrate kinase activity
HME7025_01026	COG2183	response to ionizing radiation
HME7025_01028	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HME7025_01029	COG0587	DNA-directed DNA polymerase activity
HME7025_01034	COG2135	peptidase activity
HME7025_01037	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HME7025_01038	COG3118	belongs to the thioredoxin family
HME7025_01038	COG0492	ferredoxin-NADP+ reductase activity
HME7025_01041	COG0500	methyltransferase
HME7025_01044	COG3258	Cytochrome c
HME7025_01052	COG1054	Belongs to the UPF0176 family
HME7025_01053	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HME7025_01053	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HME7025_01054	COG0730	response to heat
HME7025_01057	COG0673	inositol 2-dehydrogenase activity
HME7025_01059	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HME7025_01059	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HME7025_01064	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HME7025_01065	COG1119	ATPase activity
HME7025_01066	COG0006	proline dipeptidase activity
HME7025_01067	COG1629	transport
HME7025_01068	COG0702	epimerase
HME7025_01076	COG1129	ABC transporter
HME7025_01077	COG1172	Belongs to the binding-protein-dependent transport system permease family
HME7025_01078	COG1879	ABC-type sugar transport system periplasmic component
HME7025_01082	COG1473	amidohydrolase
HME7025_01088	COG1215	transferase activity, transferring glycosyl groups
HME7025_01090	COG2205	protein histidine kinase activity
HME7025_01090	COG0784	Response regulator, receiver
HME7025_01097	COG0423	glycine-tRNA ligase activity
HME7025_01098	COG0859	PFAM glycosyl transferase family 9
HME7025_01101	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HME7025_01101	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HME7025_01102	COG0259	pyridoxamine-phosphate oxidase activity
HME7025_01106	COG0739	heme binding
HME7025_01107	COG0492	ferredoxin-NADP+ reductase activity
HME7025_01108	COG1301	dicarboxylic acid transport
HME7025_01109	COG0281	malic enzyme
HME7025_01109	COG0280	phosphate acetyltransferase
HME7025_01112	COG3876	Protein conserved in bacteria
HME7025_01113	COG0519	Catalyzes the synthesis of GMP from XMP
HME7025_01113	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HME7025_01114	COG2195	Cleaves the N-terminal amino acid of tripeptides
HME7025_01116	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HME7025_01116	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HME7025_01118	COG0602	queuosine metabolic process
HME7025_01121	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HME7025_01124	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HME7025_01125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HME7025_01126	COG0714	Associated with various cellular activities
HME7025_01127	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HME7025_01133	COG3609	addiction module antidote protein, CC2985 family
HME7025_01136	COG2308	Evidence 4 Homologs of previously reported genes of
HME7025_01137	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HME7025_01138	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HME7025_01138	COG1796	DNA polymerase
HME7025_01139	COG1611	Belongs to the LOG family
HME7025_01140	COG0698	ribose 5-phosphate isomerase
HME7025_01142	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HME7025_01143	COG4591	ABC-type transport system involved in lipoprotein release permease component
HME7025_01144	COG1301	dicarboxylic acid transport
HME7025_01151	COG0746	molybdenum cofactor guanylyltransferase activity
HME7025_01152	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HME7025_01153	COG0101	tRNA pseudouridine synthase activity
HME7025_01154	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HME7025_01156	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HME7025_01158	COG0484	heat shock protein binding
HME7025_01159	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HME7025_01160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HME7025_01162	COG3292	Two component regulator propeller
HME7025_01162	COG0745	RESPONSE REGULATOR receiver
HME7025_01162	COG2205	protein histidine kinase activity
HME7025_01167	COG0482	sulfurtransferase activity
HME7025_01170	COG0408	coproporphyrinogen oxidase activity
HME7025_01173	COG1663	tetraacyldisaccharide 4'-kinase activity
HME7025_01175	COG1943	Transposase
HME7025_01178	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HME7025_01180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HME7025_01196	COG1309	transcriptional regulator
HME7025_01201	COG0004	ammonium transporteR
HME7025_01202	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HME7025_01205	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HME7025_01206	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HME7025_01208	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HME7025_01210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HME7025_01213	COG3254	rhamnose metabolic process
HME7025_01219	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HME7025_01225	COG0686	Belongs to the AlaDH PNT family
HME7025_01227	COG2814	Major facilitator Superfamily
HME7025_01228	COG1566	PFAM secretion protein HlyD family protein
HME7025_01232	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HME7025_01233	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HME7025_01235	COG0758	DNA mediated transformation
HME7025_01236	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HME7025_01238	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HME7025_01240	COG0488	(ABC) transporter
HME7025_01241	COG0673	inositol 2-dehydrogenase activity
HME7025_01242	COG1012	belongs to the aldehyde dehydrogenase family
HME7025_01246	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HME7025_01247	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HME7025_01248	COG0415	Belongs to the DNA photolyase family
HME7025_01250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HME7025_01251	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HME7025_01256	COG0156	8-amino-7-oxononanoate synthase activity
HME7025_01257	COG0405	Gamma-glutamyltransferase
HME7025_01259	COG3104	oligopeptide transport
HME7025_01260	COG1192	Involved in chromosome partitioning
HME7025_01261	COG1475	DNA binding
HME7025_01263	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HME7025_01266	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HME7025_01268	COG0268	Binds directly to 16S ribosomal RNA
HME7025_01269	COG2003	Belongs to the UPF0758 family
HME7025_01271	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HME7025_01271	COG0131	Imidazoleglycerol-phosphate dehydratase
HME7025_01273	COG0513	Belongs to the DEAD box helicase family
HME7025_01275	COG2967	ApaG domain
HME7025_01276	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HME7025_01278	COG0247	lactate metabolic process
HME7025_01278	COG0277	FAD linked oxidase domain protein
HME7025_01279	COG0577	efflux transmembrane transporter activity
HME7025_01279	COG1136	(ABC) transporter
HME7025_01280	COG0039	L-malate dehydrogenase activity
HME7025_01282	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HME7025_01283	COG0154	amidase activity
HME7025_01284	COG0791	NLP P60 protein
HME7025_01284	COG1388	LysM domain
HME7025_01285	COG0632	four-way junction helicase activity
HME7025_01288	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HME7025_01292	COG1131	(ABC) transporter
HME7025_01293	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HME7025_01294	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HME7025_01294	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HME7025_01295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HME7025_01296	COG1078	dGTPase activity
HME7025_01300	COG0277	FAD linked oxidase domain protein
HME7025_01304	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HME7025_01305	COG0066	3-isopropylmalate dehydratase activity
HME7025_01307	COG0473	3-isopropylmalate dehydrogenase activity
HME7025_01309	COG4946	Tricorn protease homolog
HME7025_01309	COG0823	Involved in the tonB-independent uptake of proteins
HME7025_01309	COG1506	peptidase
HME7025_01310	COG1363	Peptidase, m42
HME7025_01311	COG0205	6-phosphofructokinase activity
HME7025_01312	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HME7025_01315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HME7025_01317	COG0012	GTP binding
HME7025_01319	COG0488	(ABC) transporter
HME7025_01320	COG0069	glutamate synthase activity
HME7025_01321	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HME7025_01322	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HME7025_01325	COG0009	L-threonylcarbamoyladenylate synthase
HME7025_01328	COG0542	response to heat
HME7025_01329	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_01332	COG0228	four-way junction DNA binding
HME7025_01333	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HME7025_01334	COG0336	Belongs to the RNA methyltransferase TrmD family
HME7025_01335	COG0697	spore germination
HME7025_01336	COG2755	lipolytic protein G-D-S-L family
HME7025_01336	COG0657	acetylesterase activity
HME7025_01337	COG0531	amino acid
HME7025_01339	COG1629	transport
HME7025_01342	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HME7025_01343	COG0825	malonyl-CoA metabolic process
HME7025_01344	COG1011	Hydrolase
HME7025_01346	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HME7025_01348	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_01349	COG1216	Glycosyl transferase, family 2
HME7025_01350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HME7025_01351	COG0706	membrane insertase activity
HME7025_01352	COG0504	CTP synthase activity
HME7025_01359	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HME7025_01360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HME7025_01361	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HME7025_01362	COG0508	dehydrogenase complex catalyzes the overall conversion of
HME7025_01363	COG0481	GTPase activity
HME7025_01364	COG0006	proline dipeptidase activity
HME7025_01365	COG2226	methyltransferase
HME7025_01368	COG0124	histidyl-tRNA synthetase
HME7025_01369	COG0166	Belongs to the GPI family
HME7025_01371	COG0450	alkyl hydroperoxide reductase
HME7025_01373	COG0719	Fe-S assembly protein
HME7025_01375	COG0564	pseudouridine synthase activity
HME7025_01376	COG0456	acetyltransferase
HME7025_01377	COG2814	Major facilitator Superfamily
HME7025_01378	COG0738	Major facilitator superfamily
HME7025_01379	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HME7025_01380	COG0459	protein refolding
HME7025_01381	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HME7025_01385	COG3604	Transcriptional regulator
HME7025_01386	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HME7025_01387	COG1136	(ABC) transporter
HME7025_01388	COG0045	succinate-CoA ligase (ADP-forming) activity
HME7025_01389	COG0179	Fumarylacetoacetate (FAA) hydrolase
HME7025_01390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HME7025_01391	COG3959	Transketolase, thiamine diphosphate binding domain
HME7025_01392	COG3958	Transketolase
HME7025_01394	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HME7025_01396	COG0436	Aminotransferase
HME7025_01399	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HME7025_01401	COG0067	glutamate synthase
HME7025_01401	COG0069	glutamate synthase activity
HME7025_01401	COG0070	glutamate synthase
HME7025_01407	COG0438	transferase activity, transferring glycosyl groups
HME7025_01408	COG0438	transferase activity, transferring glycosyl groups
HME7025_01410	COG0110	maltose O-acetyltransferase activity
HME7025_01411	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HME7025_01412	COG0297	glycogen (starch) synthase activity
HME7025_01413	COG1605	Chorismate mutase
HME7025_01413	COG0077	Prephenate dehydratase
HME7025_01414	COG0196	riboflavin kinase activity
HME7025_01415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HME7025_01416	COG1968	undecaprenyl-diphosphatase activity
HME7025_01418	COG2177	Part of the ABC transporter FtsEX involved in
HME7025_01420	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HME7025_01431	COG0577	efflux transmembrane transporter activity
HME7025_01435	COG0084	hydrolase, TatD family'
HME7025_01436	COG0726	polysaccharide deacetylase
HME7025_01437	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HME7025_01438	COG1331	Highly conserved protein containing a thioredoxin domain
HME7025_01439	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HME7025_01443	COG0583	DNA-binding transcription factor activity
HME7025_01445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HME7025_01447	COG0463	Glycosyl transferase, family 2
HME7025_01450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HME7025_01451	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HME7025_01452	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HME7025_01457	COG0738	Major facilitator superfamily
HME7025_01459	COG2721	sulfolactate sulfo-lyase activity
HME7025_01460	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_01464	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_01467	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_01468	COG0129	dihydroxy-acid dehydratase activity
HME7025_01473	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HME7025_01476	COG0443	Heat shock 70 kDa protein
HME7025_01477	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HME7025_01479	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HME7025_01480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HME7025_01481	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HME7025_01482	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HME7025_01487	COG0318	PFAM AMP-dependent synthetase and ligase
HME7025_01489	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HME7025_01492	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HME7025_01492	COG0116	Belongs to the methyltransferase superfamily
HME7025_01493	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HME7025_01497	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HME7025_01498	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HME7025_01499	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HME7025_01501	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HME7025_01502	COG3118	belongs to the thioredoxin family
HME7025_01505	COG0180	Tryptophanyl-tRNA synthetase
HME7025_01506	COG0671	phosphoesterase, PA-phosphatase related
HME7025_01508	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HME7025_01510	COG0004	ammonium transporteR
HME7025_01511	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HME7025_01512	COG0174	glutamine synthetase
HME7025_01515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HME7025_01518	COG0508	dehydrogenase complex catalyzes the overall conversion of
HME7025_01519	COG1058	Belongs to the CinA family
HME7025_01519	COG1546	Belongs to the CinA family
HME7025_01522	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HME7025_01524	COG0673	inositol 2-dehydrogenase activity
HME7025_01525	COG0720	synthase
HME7025_01526	COG0302	gtp cyclohydrolase
HME7025_01527	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_01528	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HME7025_01529	COG0494	nUDIX hydrolase
HME7025_01530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HME7025_01532	COG0813	purine-nucleoside phosphorylase activity
HME7025_01535	COG1054	Belongs to the UPF0176 family
HME7025_01539	COG2153	protein acetylation
HME7025_01540	COG1702	phosphate starvation-inducible protein PhoH
HME7025_01542	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HME7025_01543	COG0300	oxidoreductase activity
HME7025_01545	COG2217	Heavy metal translocating P-type atpase
HME7025_01547	COG3278	Belongs to the heme-copper respiratory oxidase family
HME7025_01553	COG4232	protein-disulfide reductase activity
HME7025_01555	COG4191	Histidine kinase
HME7025_01559	COG0659	secondary active sulfate transmembrane transporter activity
HME7025_01560	COG3002	Belongs to the UPF0753 family
HME7025_01561	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HME7025_01563	COG0673	inositol 2-dehydrogenase activity
HME7025_01566	COG2366	antibiotic biosynthetic process
HME7025_01567	COG1250	3-hydroxyacyl-CoA dehydrogenase
HME7025_01570	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_01571	COG1063	alcohol dehydrogenase
HME7025_01574	COG1368	sulfuric ester hydrolase activity
HME7025_01580	COG2271	Major facilitator Superfamily
HME7025_01581	COG1063	alcohol dehydrogenase
HME7025_01583	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HME7025_01588	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HME7025_01598	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HME7025_01599	COG1185	polyribonucleotide nucleotidyltransferase activity
HME7025_01600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HME7025_01601	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HME7025_01603	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HME7025_01610	COG0285	dihydrofolate synthase activity
HME7025_01611	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HME7025_01612	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HME7025_01613	COG2171	N-acyltransferase activity
HME7025_01614	COG2996	Protein conserved in bacteria
HME7025_01618	COG5002	protein histidine kinase activity
HME7025_01625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HME7025_01626	COG3599	regulation of cell shape
HME7025_01630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HME7025_01635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HME7025_01636	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HME7025_01638	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HME7025_01639	COG2353	YceI-like domain
HME7025_01650	COG0673	inositol 2-dehydrogenase activity
HME7025_01655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HME7025_01657	COG0284	orotidine-5'-phosphate decarboxylase activity
HME7025_01660	COG0540	Belongs to the ATCase OTCase family
HME7025_01662	COG0612	Peptidase, M16
HME7025_01663	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HME7025_01664	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HME7025_01667	COG1705	Flagellar rod assembly protein muramidase FlgJ
HME7025_01667	COG1388	LysM domain
HME7025_01669	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HME7025_01673	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HME7025_01674	COG4221	oxidoreductase activity
HME7025_01675	COG0193	aminoacyl-tRNA hydrolase activity
HME7025_01677	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HME7025_01677	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HME7025_01678	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HME7025_01679	COG4974	Belongs to the 'phage' integrase family
HME7025_01680	COG0083	homoserine kinase activity
HME7025_01681	COG0527	aspartate kinase activity
HME7025_01681	COG0460	homoserine dehydrogenase
HME7025_01682	COG2323	membrane
HME7025_01683	COG0848	biopolymer transport protein
HME7025_01685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HME7025_01685	COG0248	Ppx GppA phosphatase
HME7025_01687	COG0612	Peptidase, M16
HME7025_01689	COG2151	metal-sulfur cluster biosynthetic enzyme
HME7025_01690	COG2166	iron-sulfur cluster assembly
HME7025_01691	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HME7025_01692	COG0719	Fe-S assembly protein
HME7025_01693	COG0396	ATPase activity
HME7025_01694	COG0316	Belongs to the HesB IscA family
HME7025_01697	COG2353	YceI-like domain
HME7025_01698	COG0778	Nitroreductase
HME7025_01700	COG0009	L-threonylcarbamoyladenylate synthase
HME7025_01701	COG0018	arginyl-trna synthetase
HME7025_01702	COG0386	Belongs to the glutathione peroxidase family
HME7025_01703	COG1575	Belongs to the MenA family. Type 1 subfamily
HME7025_01709	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HME7025_01711	COG0709	Synthesizes selenophosphate from selenide and ATP
HME7025_01712	COG2267	carboxylic ester hydrolase activity
HME7025_01713	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HME7025_01714	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HME7025_01715	COG1183	phosphatidylcholine synthase activity
HME7025_01716	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HME7025_01719	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HME7025_01721	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HME7025_01723	COG1388	LysM domain
HME7025_01723	COG4932	domain protein
HME7025_01727	COG0248	Ppx GppA phosphatase
HME7025_01729	COG2204	response regulator
HME7025_01730	COG2884	Cell division ATP-binding protein ftsE
HME7025_01731	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HME7025_01740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HME7025_01741	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HME7025_01743	COG1047	Peptidyl-prolyl cis-trans
HME7025_01745	COG1561	YicC-like family, N-terminal region
HME7025_01748	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HME7025_01751	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HME7025_01756	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HME7025_01766	COG0024	Methionine aminopeptidase
HME7025_01769	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HME7025_01773	COG1739	Uncharacterized protein family UPF0029
HME7025_01774	COG0179	Fumarylacetoacetate (FAA) hydrolase
HME7025_01776	COG4115	mRNA cleavage
HME7025_01778	COG0542	response to heat
HME7025_01779	COG0784	Response regulator, receiver
HME7025_01779	COG2205	protein histidine kinase activity
HME7025_01779	COG5002	protein histidine kinase activity
HME7025_01780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HME7025_01781	COG2239	Acts as a magnesium transporter
HME7025_01782	COG1490	D-aminoacyl-tRNA deacylase activity
HME7025_01783	COG1694	Mazg nucleotide pyrophosphohydrolase
HME7025_01784	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HME7025_01786	COG2610	gluconate transmembrane transporter activity
HME7025_01791	COG0673	inositol 2-dehydrogenase activity
HME7025_01801	COG4771	TonB-dependent receptor
HME7025_01803	COG4771	TonB-dependent receptor
HME7025_01808	COG4263	nitrous-oxide reductase activity
HME7025_01809	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HME7025_01812	COG1131	(ABC) transporter
HME7025_01816	COG2205	protein histidine kinase activity
HME7025_01816	COG0784	Response regulator, receiver
HME7025_01823	COG1024	Enoyl-CoA hydratase
HME7025_01826	COG0017	Asparaginyl-tRNA synthetase
HME7025_01827	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HME7025_01829	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HME7025_01830	COG0534	Mate efflux family protein
HME7025_01834	COG0508	dehydrogenase complex catalyzes the overall conversion of
HME7025_01835	COG0567	Dehydrogenase, E1 component
HME7025_01838	COG0326	Molecular chaperone. Has ATPase activity
HME7025_01841	COG0037	tRNA processing
HME7025_01846	COG0352	thiamine-phosphate diphosphorylase activity
HME7025_01847	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HME7025_01848	COG2226	methyltransferase
HME7025_01852	COG1132	(ABC) transporter
HME7025_01855	COG0793	Belongs to the peptidase S41A family
HME7025_01857	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HME7025_01858	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HME7025_01860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HME7025_01863	COG2217	Heavy metal translocating P-type atpase
HME7025_01871	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HME7025_01872	COG0531	amino acid
HME7025_01875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HME7025_01876	COG1012	belongs to the aldehyde dehydrogenase family
HME7025_01878	COG1064	alcohol dehydrogenase
HME7025_01881	COG1136	(ABC) transporter
HME7025_01882	COG3274	enterobacterial common antigen metabolic process
HME7025_01883	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HME7025_01883	COG2010	Cytochrome c
HME7025_01886	COG0673	inositol 2-dehydrogenase activity
HME7025_01887	COG1556	Lactate utilization protein
HME7025_01888	COG1139	Iron-sulfur cluster binding protein
HME7025_01889	COG0247	lactate metabolic process
HME7025_01891	COG4952	isomerase
HME7025_01892	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_01892	COG3347	Dehydrogenase
HME7025_01893	COG1473	amidohydrolase
HME7025_01895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HME7025_01897	COG0315	cyclic pyranopterin monophosphate synthase activity
HME7025_01898	COG0303	'Molybdopterin
HME7025_01899	COG4948	Mandelate Racemase Muconate Lactonizing
HME7025_01901	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HME7025_01909	COG3622	Belongs to the hyi family
HME7025_01910	COG0640	Transcriptional regulator
HME7025_01914	COG3217	Mosc domain protein beta barrel domain protein
HME7025_01914	COG0633	Ferredoxin
HME7025_01916	COG1132	(ABC) transporter
HME7025_01917	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HME7025_01920	COG1862	Preprotein translocase
HME7025_01922	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HME7025_01928	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HME7025_01931	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HME7025_01932	COG2267	carboxylic ester hydrolase activity
HME7025_01934	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HME7025_01936	COG0544	peptidyl-prolyl cis-trans isomerase activity
HME7025_01939	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HME7025_01942	COG0673	inositol 2-dehydrogenase activity
HME7025_01944	COG0358	DNA primase activity
HME7025_01945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HME7025_01946	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HME7025_01948	COG0187	DNA topoisomerase II activity
HME7025_01949	COG0138	bifunctional purine biosynthesis protein purh
HME7025_01950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HME7025_01951	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_01954	COG1917	Cupin 2, conserved barrel domain protein
HME7025_01954	COG2207	Transcriptional regulator
HME7025_01964	COG4221	oxidoreductase activity
HME7025_01966	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HME7025_01970	COG1506	peptidase
HME7025_01970	COG0823	Involved in the tonB-independent uptake of proteins
HME7025_01971	COG3590	peptidase
HME7025_01972	COG0702	epimerase
HME7025_01973	COG1629	transport
HME7025_01975	COG4771	TonB-dependent receptor
HME7025_01976	COG2610	gluconate transmembrane transporter activity
HME7025_01982	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HME7025_01985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HME7025_01986	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HME7025_01989	COG1496	oxidoreductase activity
HME7025_01998	COG0575	Belongs to the CDS family
HME7025_02001	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HME7025_02006	COG0528	UMP kinase activity
HME7025_02007	COG0233	cytoplasmic translational termination
HME7025_02012	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HME7025_02013	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HME7025_02014	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HME7025_02015	COG0165	Argininosuccinate lyase
HME7025_02021	COG4191	Histidine kinase
HME7025_02023	COG2226	methyltransferase
HME7025_02028	COG0363	glucosamine-6-phosphate deaminase activity
HME7025_02029	COG0247	lactate metabolic process
HME7025_02029	COG0277	FAD linked oxidase domain protein
HME7025_02031	COG0463	Glycosyl transferase, family 2
HME7025_02033	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HME7025_02033	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HME7025_02034	COG0254	rRNA binding
HME7025_02035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HME7025_02036	COG0470	DNA polymerase III
HME7025_02037	COG0181	hydroxymethylbilane synthase activity
HME7025_02038	COG1091	dTDP-4-dehydrorhamnose reductase activity
HME7025_02039	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HME7025_02040	COG0563	adenylate kinase activity
HME7025_02041	COG4771	TonB-dependent receptor
HME7025_02043	COG0823	Involved in the tonB-independent uptake of proteins
HME7025_02045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HME7025_02053	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HME7025_02058	COG0497	DNA recombination
HME7025_02060	COG1999	signal sequence binding
HME7025_02064	COG0668	transmembrane transport
HME7025_02065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HME7025_02066	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HME7025_02068	COG0028	Belongs to the TPP enzyme family
HME7025_02069	COG0129	dihydroxy-acid dehydratase activity
HME7025_02070	COG5265	(ABC) transporter
HME7025_02071	COG0579	oxidoreductase
HME7025_02072	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HME7025_02073	COG0564	pseudouridine synthase activity
HME7025_02075	COG4974	Belongs to the 'phage' integrase family
HME7025_02083	COG2217	Heavy metal translocating P-type atpase
HME7025_02085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HME7025_02088	COG2132	Multicopper oxidase
HME7025_02101	COG3458	cephalosporin-C deacetylase activity
HME7025_02104	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_02106	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HME7025_02117	COG4771	TonB-dependent receptor
HME7025_02121	COG4771	TonB-dependent receptor
HME7025_02126	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HME7025_02128	COG1063	alcohol dehydrogenase
HME7025_02129	COG1131	(ABC) transporter
HME7025_02133	COG2315	Protein conserved in bacteria
HME7025_02136	COG0346	lactoylglutathione lyase activity
HME7025_02137	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HME7025_02139	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HME7025_02139	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HME7025_02140	COG1024	Enoyl-CoA hydratase
HME7025_02140	COG1250	3-hydroxyacyl-CoA dehydrogenase
HME7025_02141	COG0183	Belongs to the thiolase family
HME7025_02142	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HME7025_02143	COG3384	dioxygenase
HME7025_02144	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HME7025_02145	COG0156	8-amino-7-oxononanoate synthase activity
HME7025_02146	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HME7025_02147	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HME7025_02151	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HME7025_02154	COG1007	ATP synthesis coupled electron transport
HME7025_02160	COG5180	pathogenesis
HME7025_02160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HME7025_02161	COG0195	Participates in both transcription termination and antitermination
HME7025_02162	COG0779	Required for maturation of 30S ribosomal subunits
HME7025_02163	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HME7025_02165	COG4206	TonB-dependent receptor
HME7025_02166	COG0519	Catalyzes the synthesis of GMP from XMP
HME7025_02167	COG0463	Glycosyl transferase, family 2
HME7025_02168	COG1981	membrane
HME7025_02169	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HME7025_02173	COG1446	asparaginase
HME7025_02181	COG1595	DNA-templated transcription, initiation
HME7025_02189	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HME7025_02190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HME7025_02192	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HME7025_02193	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HME7025_02195	COG1595	DNA-templated transcription, initiation
HME7025_02197	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HME7025_02199	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HME7025_02202	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HME7025_02203	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HME7025_02210	COG2205	protein histidine kinase activity
HME7025_02212	COG2808	Putative FMN-binding domain
HME7025_02214	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HME7025_02215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HME7025_02215	COG1648	precorrin-2 dehydrogenase activity
HME7025_02216	COG0251	oxidation-reduction process
HME7025_02217	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HME7025_02217	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HME7025_02218	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HME7025_02220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HME7025_02221	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_02229	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HME7025_02232	COG0811	peptide transport
HME7025_02237	COG1619	proteins homologs of microcin C7 resistance protein MccF
HME7025_02238	COG0606	chelatase, subunit chli
HME7025_02241	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HME7025_02244	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HME7025_02246	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HME7025_02247	COG0527	aspartate kinase activity
HME7025_02248	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HME7025_02252	COG2255	four-way junction helicase activity
HME7025_02253	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HME7025_02254	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HME7025_02257	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HME7025_02259	COG0488	(ABC) transporter
HME7025_02261	COG0714	Associated with various cellular activities
HME7025_02262	COG2755	lipolytic protein G-D-S-L family
HME7025_02268	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HME7025_02270	COG3158	transport of potassium into the cell
HME7025_02271	COG0412	Dienelactone hydrolase
HME7025_02274	COG0175	sulfate reduction
HME7025_02275	COG0175	sulfate reduction
HME7025_02278	COG0525	valine-tRNA ligase activity
HME7025_02280	COG1132	(ABC) transporter
HME7025_02291	COG0564	pseudouridine synthase activity
HME7025_02292	COG1959	2 iron, 2 sulfur cluster binding
HME7025_02293	COG0049	tRNA binding
HME7025_02294	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HME7025_02295	COG1312	Catalyzes the dehydration of D-mannonate
HME7025_02297	COG0514	ATP-dependent DNA helicase (RecQ)
HME7025_02298	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HME7025_02300	COG0750	zinc metalloprotease
HME7025_02301	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HME7025_02304	COG0649	NAD binding
HME7025_02305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HME7025_02307	COG0552	protein localization to endoplasmic reticulum
HME7025_02311	COG1160	GTP binding
HME7025_02312	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HME7025_02316	COG1960	acyl-CoA dehydrogenase activity
HME7025_02319	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HME7025_02320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HME7025_02322	COG0051	transcription antitermination factor activity, RNA binding
HME7025_02324	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HME7025_02325	COG0594	ribonuclease P activity
HME7025_02326	COG0793	Belongs to the peptidase S41A family
HME7025_02327	COG1214	PFAM Peptidase M22, glycoprotease
HME7025_02331	COG3001	Fructosamine kinase
HME7025_02332	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HME7025_02335	COG0708	Exodeoxyribonuclease III
HME7025_02339	COG2176	DNA-directed DNA polymerase activity
HME7025_02340	COG0713	ATP synthesis coupled electron transport
HME7025_02341	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HME7025_02342	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_02343	COG1007	ATP synthesis coupled electron transport
HME7025_02352	COG0215	cysteine-tRNA ligase activity
HME7025_02355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HME7025_02356	COG1217	gtp-binding protein TYPA
HME7025_02357	COG0658	competence protein
HME7025_02357	COG2333	competence protein COMEC
HME7025_02358	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HME7025_02359	COG0194	GDP metabolic process
HME7025_02361	COG1595	DNA-templated transcription, initiation
HME7025_02364	COG1077	Cell shape determining protein MreB Mrl
HME7025_02366	COG1187	pseudouridine synthase activity
HME7025_02370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HME7025_02371	COG1404	Belongs to the peptidase S8 family
HME7025_02372	COG0604	alcohol dehydrogenase
HME7025_02374	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_02377	COG0659	secondary active sulfate transmembrane transporter activity
HME7025_02378	COG0288	reversible hydration of carbon dioxide
HME7025_02379	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HME7025_02385	COG1774	PSP1 C-terminal conserved region
HME7025_02388	COG1566	PFAM secretion protein HlyD family protein
HME7025_02390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HME7025_02391	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HME7025_02391	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HME7025_02394	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HME7025_02395	COG2264	protein methyltransferase activity
HME7025_02397	COG0860	N-Acetylmuramoyl-L-alanine amidase
HME7025_02403	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HME7025_02408	COG0505	Belongs to the CarA family
HME7025_02409	COG0203	ribosomal protein L17
HME7025_02410	COG0202	RNA polymerase activity
HME7025_02411	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HME7025_02412	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HME7025_02413	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HME7025_02414	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HME7025_02415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HME7025_02416	COG0024	Methionine aminopeptidase
HME7025_02417	COG0201	protein transport
HME7025_02418	COG0200	Binds to the 23S rRNA
HME7025_02419	COG1841	ribosomal large subunit assembly
HME7025_02420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HME7025_02421	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HME7025_02422	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HME7025_02423	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HME7025_02424	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HME7025_02425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HME7025_02426	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HME7025_02427	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HME7025_02428	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HME7025_02429	COG0255	Belongs to the universal ribosomal protein uL29 family
HME7025_02430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HME7025_02431	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HME7025_02432	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HME7025_02433	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HME7025_02434	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HME7025_02435	COG0089	rRNA binding
HME7025_02436	COG0088	Forms part of the polypeptide exit tunnel
HME7025_02437	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HME7025_02440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HME7025_02440	COG1648	precorrin-2 dehydrogenase activity
HME7025_02441	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HME7025_02442	COG1610	YqeY-like protein
HME7025_02444	COG0584	glycerophosphoryl diester phosphodiesterase
HME7025_02448	COG2304	oxidoreductase activity
HME7025_02449	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HME7025_02453	COG0586	Pfam SNARE associated Golgi protein
HME7025_02454	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HME7025_02456	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HME7025_02457	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HME7025_02458	COG1045	serine acetyltransferase
HME7025_02462	COG1228	amidohydrolase
HME7025_02463	COG1228	amidohydrolase
HME7025_02468	COG4206	TonB-dependent receptor
HME7025_02472	COG1137	ATPase activity
HME7025_02473	COG0626	cystathionine gamma-synthase activity
HME7025_02480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_02484	COG0673	inositol 2-dehydrogenase activity
HME7025_02485	COG0367	asparagine synthase
HME7025_02486	COG0297	glycogen (starch) synthase activity
HME7025_02486	COG0438	transferase activity, transferring glycosyl groups
HME7025_02487	COG0367	asparagine synthase
HME7025_02489	COG0500	methyltransferase
HME7025_02493	COG0110	maltose O-acetyltransferase activity
HME7025_02496	COG0107	imidazoleglycerol-phosphate synthase activity
HME7025_02497	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HME7025_02498	COG2089	acid synthase
HME7025_02499	COG2089	acid synthase
HME7025_02500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HME7025_02500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HME7025_02502	COG0107	imidazoleglycerol-phosphate synthase activity
HME7025_02505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HME7025_02506	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HME7025_02509	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HME7025_02510	COG1086	Polysaccharide biosynthesis protein
HME7025_02512	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HME7025_02514	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HME7025_02515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HME7025_02515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HME7025_02524	COG0702	epimerase
HME7025_02525	COG4771	TonB-dependent receptor
HME7025_02530	COG1741	Belongs to the pirin family
HME7025_02531	COG2353	YceI-like domain
HME7025_02537	COG1611	Belongs to the LOG family
HME7025_02543	COG3119	arylsulfatase activity
HME7025_02545	COG3250	beta-galactosidase activity
HME7025_02548	COG0363	glucosamine-6-phosphate deaminase activity
HME7025_02552	COG1741	Belongs to the pirin family
HME7025_02554	COG4771	TonB-dependent receptor
HME7025_02560	COG2226	methyltransferase
HME7025_02570	COG2271	Major facilitator Superfamily
HME7025_02571	COG1028	Short-chain dehydrogenase reductase Sdr
HME7025_02572	COG1312	Catalyzes the dehydration of D-mannonate
HME7025_02573	COG1609	Transcriptional regulator
HME7025_02576	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HME7025_02579	COG2855	membrane
HME7025_02597	COG3250	beta-galactosidase activity
HME7025_02600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HME7025_02602	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HME7025_02604	COG0673	inositol 2-dehydrogenase activity
HME7025_02606	COG1764	response to oxidative stress
HME7025_02612	COG2272	Belongs to the type-B carboxylesterase lipase family
HME7025_02618	COG0697	spore germination
HME7025_02619	COG2814	Major facilitator Superfamily
HME7025_02621	COG1132	(ABC) transporter
HME7025_02624	COG3655	Transcriptional regulator
HME7025_02641	COG2382	esterase
HME7025_02641	COG3693	PFAM glycoside hydrolase, family 10
HME7025_02647	COG0657	acetylesterase activity
HME7025_02647	COG2755	lipolytic protein G-D-S-L family
HME7025_02650	COG0656	L-ascorbic acid biosynthetic process
HME7025_02655	COG1733	regulation of RNA biosynthetic process
HME7025_02662	COG0318	PFAM AMP-dependent synthetase and ligase
HME7025_02666	COG0583	DNA-binding transcription factor activity
HME7025_02668	COG0673	inositol 2-dehydrogenase activity
HME7025_02669	COG0823	Involved in the tonB-independent uptake of proteins