locus_tag old_locus_tag gene Name start end strand product note type ID NCBI HME7025_00001 HME7025_00001 HME7025_00001 1 1698 + Gluconate 2-dehydrogenase (acceptor) Cell membrane%3B FAD%3B Flavoprotein%3B Membrane%3B Oxidoreductase.%3B Catalytic subunit of fructose dehydrogenase%2C an enzyme that catalyzes the oxidation of D-fructose to produce 5-keto-D- fructose%3B Belongs to the GMC oxidoreductase family%3B KEGG: bif:N288_03430 gluconate 2-dehydrogenase alpha chain gene gene-HME7025_00001 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00001 HME7025_00002 HME7025_00002 HME7025_00002 1748 2155 - Putative regulatory protein MalR DNA-binding%3B Transcription%3B Transcription regulation.%3B Potential regulator of the malBH genes. Contains 1 HTH hxlR-type DNA-binding domain gene gene-HME7025_00002 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00002 HME7025_00003 HME7025_00003 dltE dltE 2254 3018 + putative oxidoreductase DltE Cytoplasm%3B NAD%3B Oxidoreductase.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: sod:Sant_P0117 uncharacterized oxidoreductase%3B Oxidoreductases gene gene-HME7025_00003 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00003 HME7025_00004 HME7025_00004 HME7025_00004 3024 4031 + Alcohol dehydrogenase Chloroplast%3B Membrane%3B NAD%3B Oxidoreductase%3B Plastid%3B Plastid inner membrane.%3B Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily%3B KEGG: pna:Pnap_1291 alcohol dehydrogenase gene gene-HME7025_00004 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00004 HME7025_00005 HME7025_00005 bla2 bla2 4166 4921 - Beta-lactamase Antibiotic resistance%3B Hydrolase%3B Metal-binding%3B Periplasm%3B Plasmid%3B Signal%3B Zinc.%3B Confers resistance to many beta-lactam antibiotics%2C including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin%3B Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family%3B KEGG: dfe:Dfer_1371 metallo-beta-lactamase class B gene gene-HME7025_00005 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00005 HME7025_00006 HME7025_00006 HME7025_00006 4971 5711 - hypothetical protein gene gene-HME7025_00006 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00006 HME7025_00007 HME7025_00007 HME7025_00007 5715 8525 - hypothetical protein gene gene-HME7025_00007 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00007 HME7025_00008 HME7025_00008 HME7025_00008 8873 9721 + hypothetical protein gene gene-HME7025_00008 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00008 HME7025_00009 HME7025_00009 xynA xynA 9944 10885 + Endo-1%2C4-beta-xylanase KEGG: rba:RB3550 endo-1%2C4-beta-xylanase gene gene-HME7025_00009 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00009 HME7025_00010 HME7025_00010 HME7025_00010 11111 11725 - hypothetical protein gene gene-HME7025_00010 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00010 HME7025_00011 HME7025_00011 kynB kynB 11964 12854 + Arylformamidase KEGG: fgi:OP10G_3001 arylformamidase gene gene-HME7025_00011 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00011 HME7025_00012 HME7025_00012 HME7025_00012 13016 13834 - uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_00012 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00012 HME7025_00013 HME7025_00013 HME7025_00013 13848 14759 - hypothetical protein gene gene-HME7025_00013 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00013 HME7025_00014 HME7025_00014 rfbC rfbC 14749 15273 - dTDP-4-dehydrorhamnose 3%2C5-epimerase Isomerase.%3B Epimerase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1. 75 M instead of 3. 4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg%2C consisting of a sulfated hexose%2C 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier%3B Belongs to the dTDP-4-dehydrorhamnose 3%2C5-epimerase family%3B KEGG: rrd:RradSPS_2711 dTDP-4-dehydrorhamnose 3%2C5-epimerase gene gene-HME7025_00014 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00014 HME7025_00015 HME7025_00015 HME7025_00015 15655 16236 - hypothetical protein gene gene-HME7025_00015 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00015 HME7025_00016 HME7025_00016 HME7025_00016 16399 17154 - hypothetical protein gene gene-HME7025_00016 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00016 HME7025_00017 HME7025_00017 HME7025_00017 17169 18272 - hypothetical protein gene gene-HME7025_00017 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00017 HME7025_00018 HME7025_00018 HME7025_00018 18284 18799 - hypothetical protein gene gene-HME7025_00018 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00018 HME7025_00019 HME7025_00019 HME7025_00019 18875 19237 + putative HTH-type transcriptional regulator YdeP DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH hxlR-type DNA-binding domain gene gene-HME7025_00019 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00019 HME7025_00020 HME7025_00020 HME7025_00020 19947 20546 - Copper chaperone CopZ Chaperone%3B Copper%3B Cytoplasm%3B Metal-binding.%3B Acts as a copper chaperone by delivering 2 Cu(+) ions to CopY Zn(2+)-bound form. This transfer results in displacement of zinc and dissociation of CopY from the promoter%2C allowing transcription of the copYZAB operon%3B Contains 1 HMA domain gene gene-HME7025_00020 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00020 HME7025_00021 HME7025_00021 HME7025_00021 20543 20917 - Cadmium resistance transcriptional regulatory protein CadC Cadmium%3B Cadmium resistance%3B DNA-binding%3B Metal-binding%3B Plasmid%3B Transcription%3B Transcription regulation.%3B Metal-binding repressor for the cad operon. Involved in resistance to heavy metals%2C such as cadmium%2C bismuth%2C zinc or lead. Metal binding causes the repressor to dissociate from the DNA (By similarity)%3B Contains 1 HTH arsR-type DNA-binding domain gene gene-HME7025_00021 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00021 HME7025_00022 HME7025_00022 HME7025_00022 21469 21545 - tRNA-Asn tRNA gene-HME7025_00022 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00022 HME7025_00023 HME7025_00023 HME7025_00023 21631 23022 - Multidrug resistance protein MdtA Cell inner membrane%3B Cell membrane%3B Membrane%3B Signal%3B Transport.%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene-HME7025_00023 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00023 HME7025_00024 HME7025_00024 HME7025_00024 23043 24509 - hypothetical protein gene gene-HME7025_00024 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00024 HME7025_00025 HME7025_00025 vanX vanX 24604 25293 - D-Ala-D-Ala dipeptidase KEGG: lby:Lbys_1708 D-alanyl-D-alanine dipeptidase gene gene-HME7025_00025 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00025 HME7025_00026 HME7025_00026 HME7025_00026 25366 26601 + Spore maturation protein Cell membrane%3B Membrane%3B Sporulation%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_00026 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00026 HME7025_00027 HME7025_00027 HME7025_00027 26603 28087 - hypothetical protein gene gene-HME7025_00027 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00027 HME7025_00028 HME7025_00028 HME7025_00028 28119 28595 - hypothetical protein gene gene-HME7025_00028 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00028 HME7025_00029 HME7025_00029 gmdS gmdS 28677 29753 - GDP-mannose 4%2C6-dehydratase Insecticide resistance%3B Lyase%3B NADP.%3B Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose. Involved in susceptibility to pore- forming crystal toxins in conjunction with bre-2%2C bre-3 and bre-4. Has a role in determining brood size (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4%2C6-dehydratase subfamily%3B KEGG: lch:Lcho_2349 GDPmannose 4%2C6-dehydratase gene gene-HME7025_00029 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00029 HME7025_00030 HME7025_00030 acsL acsL 29884 31656 - Long-chain-fatty-acid--CoA ligase ATP-binding%3B Fatty acid metabolism%3B Ligase%3B Lipid metabolism%3B Nucleotide-binding.%3B Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA)%2C which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: bacc:BRDCF_11785 long-chain acyl-CoA synthetase gene gene-HME7025_00030 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00030 HME7025_00031 HME7025_00031 HME7025_00031 31752 33266 - hypothetical protein gene gene-HME7025_00031 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00031 HME7025_00032 HME7025_00032 HME7025_00032 33540 35183 - hypothetical protein gene gene-HME7025_00032 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00032 HME7025_00033 HME7025_00033 HME7025_00033 35173 36060 - hypothetical protein gene gene-HME7025_00033 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00033 HME7025_00034 HME7025_00034 HME7025_00034 36063 37925 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG Cytoplasm%3B FAD%3B Flavoprotein%3B NAD%3B tRNA processing.%3B NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA-cmnm(5)s(2)U34%3B Belongs to the MnmG family gene gene-HME7025_00034 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00034 HME7025_00035 HME7025_00035 HME7025_00035 37952 38374 - Endoribonuclease YbeY Cytoplasm%3B Endonuclease%3B Hydrolase%3B Metal-binding%3B Nuclease%3B Ribosome biogenesis%3B rRNA processing%3B Zinc.%3B Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA%3B Belongs to the endoribonuclease YbeY family gene gene-HME7025_00035 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00035 HME7025_00036 HME7025_00036 HME7025_00036 38398 38751 - UPF0102 protein Belongs to the UPF0102 family gene gene-HME7025_00036 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00036 HME7025_00037 HME7025_00037 lipB lipB 38821 39558 + Lipoyl(octanoyl) transferase Acyltransferase%3B Cytoplasm%3B Transferase.%3B Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate%3B Belongs to the LipB family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: eol:Emtol_2033 lipoyl(octanoyl) transferase gene gene-HME7025_00037 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00037 HME7025_00038 HME7025_00038 HME7025_00038 39562 40296 + hypothetical protein gene gene-HME7025_00038 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00038 HME7025_00039 HME7025_00039 wbqR wbqR 40283 40918 - UDP-3-O-acylglucosamine N-acyltransferase Acyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Repeat%3B Transferase.%3B Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxD subfamily%3B KEGG: ccr:CC_1011 UDP-perosamine 4-acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene-HME7025_00039 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00039 HME7025_00040 HME7025_00040 HME7025_00040 40920 42119 - hypothetical protein gene gene-HME7025_00040 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00040 HME7025_00041 HME7025_00041 HME7025_00041 42116 43351 - Chloride/fluoride channel protein Cell membrane%3B Chloride%3B Chloride channel%3B Ion channel%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Transports chloride and fluoride with similar efficiency%3B Belongs to the chloride channel (TC 2. A. 49) family gene gene-HME7025_00041 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00041 HME7025_00042 HME7025_00042 deaD deaD 43432 44844 + RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Nucleus%3B Ribosome biogenesis%3B RNA-binding%3B rRNA processing.%3B ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs%3B Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: fbl:Fbal_2968 ATP-dependent RNA helicase DeaD gene gene-HME7025_00042 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00042 HME7025_00043 HME7025_00043 HME7025_00043 44854 45555 + hypothetical protein gene gene-HME7025_00043 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00043 HME7025_00044 HME7025_00044 HME7025_00044 45572 47074 + hypothetical protein gene gene-HME7025_00044 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00044 HME7025_00045 HME7025_00045 HME7025_00045 47100 47609 - Gamma carbonic anhydrase 2%2C mitochondrial Lyase%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Transit peptide%3B Zinc.%3B Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide (PubMed:19808034). Mediates complex I assembly in mitochondria and respiration. Binds HCO(3)-. Required for male fertility during anther development and dehiscence to regulate the secondary thickenings of the endothecial cell wall%2C probably by modulating H(2)O(2)-dependent lignin polymerization%3B Belongs to the gamma-class carbonic anhydrase family gene gene-HME7025_00045 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00045 HME7025_00046 HME7025_00046 kdsC kdsC 47616 48128 - 3-deoxy-manno-octulosonate-8-phosphatase Hydrolase%3B Lipopolysaccharide biosynthesis%3B Magnesium%3B Metal-binding.%3B Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate (By similarity)%3B Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate%3B Belongs to the KdsC family%3B KEGG: nso:NIASO_05705 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) gene gene-HME7025_00046 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00046 HME7025_00047 HME7025_00047 HME7025_00047 48202 52863 + hypothetical protein gene gene-HME7025_00047 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00047 HME7025_00048 HME7025_00048 plsC plsC 52865 53656 + 1-acylglycerol-3-phosphate O-acyltransferase KEGG: fba:FIC_00466 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene-HME7025_00048 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00048 HME7025_00049 HME7025_00049 HME7025_00049 53660 54349 + DNA repair protein RecO DNA damage%3B DNA recombination%3B DNA repair.%3B Involved in DNA repair and RecF pathway recombination%3B Belongs to the RecO family gene gene-HME7025_00049 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00049 HME7025_00050 HME7025_00050 HME7025_00050 54346 55797 + hypothetical protein gene gene-HME7025_00050 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00050 HME7025_00051 HME7025_00051 HME7025_00051 55907 56257 + hypothetical protein gene gene-HME7025_00051 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00051 HME7025_00052 HME7025_00052 hemB hemB 56296 57267 + Porphobilinogen synthase Heme biosynthesis%3B Lyase%3B Magnesium%3B Metal-binding%3B Porphyrin biosynthesis.%3B Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit%2C each at a distinct site%2C and catalyzes their condensation to form porphobilinogen (By similarity)%3B Belongs to the ALAD family%3B KEGG: bba:Bd3444 porphobilinogen synthase gene gene-HME7025_00052 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00052 HME7025_00053 HME7025_00053 purM purM 57272 58438 + Phosphoribosylformylglycinamidine cyclo-ligase ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis.%3B Belongs to the AIR synthase family%3B KEGG: caa:Caka_2283 phosphoribosylformylglycinamidine cyclo-ligase gene gene-HME7025_00053 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00053 HME7025_00054 HME7025_00054 HME7025_00054 58565 58879 + 50S ribosomal protein L21 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B This protein binds to 23S rRNA in the presence of protein L20%3B Belongs to the ribosomal protein L21P family gene gene-HME7025_00054 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00054 HME7025_00055 HME7025_00055 HME7025_00055 58919 59332 + 50S ribosomal protein L27%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L27P family gene gene-HME7025_00055 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00055 HME7025_00056 HME7025_00056 HME7025_00056 59437 60027 + NifU-like protein Belongs to the NifU family gene gene-HME7025_00056 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00056 HME7025_00057 HME7025_00057 HME7025_00057 60097 60774 - hypothetical protein gene gene-HME7025_00057 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00057 HME7025_00058 HME7025_00058 tpiA tpiA 60865 61626 - Triose-phosphate isomerase Cytoplasm%3B Gluconeogenesis%3B Glycolysis%3B Isomerase%3B Pentose shunt.%3B Belongs to the triosephosphate isomerase family%3B KEGG: osp:Odosp_1121 triosephosphate isomerase (TIM) gene gene-HME7025_00058 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00058 HME7025_00059 HME7025_00059 nagZ nagZ 61768 64908 + Beta-N-acetylhexosaminidase Glycosidase%3B Hydrolase%3B Signal.%3B Most active towards p-nitrophenyl-N-acetyl-beta-D- glucosaminide(PNP-beta-GlcNAc) and diacetylchitobiose. Belongs to the glycosyl hydrolase 3 family%3B KEGG: glj:GKIL_0753 beta-N-acetylhexosaminidase gene gene-HME7025_00059 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00059 HME7025_00060 HME7025_00060 HME7025_00060 64913 65800 + Epimerase family protein YfcH Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily gene gene-HME7025_00060 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00060 HME7025_00061 HME7025_00061 HME7025_00061 65802 66383 + Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG1 Cytokinin biosynthesis%3B Cytoplasm%3B Hydrolase%3B Nucleus.%3B Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms%3B Belongs to the LOG family gene gene-HME7025_00061 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00061 HME7025_00062 HME7025_00062 HME7025_00062 66397 68037 + Photosystem I P700 chlorophyll a apoprotein A2 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Chlorophyll%3B Chromophore%3B Electron transport%3B Iron%3B Iron-sulfur%3B Magnesium%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Photosynthesis%3B Photosystem I%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B PsaA and PsaB bind P700%2C the primary electron donor of photosystem I (PSI)%2C as well as the electron acceptors A0%2C A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase%2C converting photonic excitation into a charge separation%2C which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0%2C A1%2C FX%2C FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6. Belongs to the PsaA/PsaB family%3B Contains 1 OmpA-like domain gene gene-HME7025_00062 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00062 HME7025_00063 HME7025_00063 HME7025_00063 68038 68331 - hypothetical protein gene gene-HME7025_00063 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00063 HME7025_00064 HME7025_00064 HME7025_00064 68430 69431 - uncharacterized protein gene gene-HME7025_00064 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00064 HME7025_00065 HME7025_00065 HME7025_00065 69535 70800 - Esterase EstB Cytoplasm%3B Hydrolase.%3B Acts on short-chain (C4-C6) fatty acid esters and triglycerides%2C including tertiary alcohol esters. Activity on p- nitrophenyl esters is generally higher than on o-nitrophenyl esters. Lacks beta-lactamase activit%3B it hydrolyzes the ester bond of cephalosporin substrates but there is no opening of the beta-lactam ring observed. Belongs to the class-A beta-lactamase family gene gene-HME7025_00065 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00065 HME7025_00066 HME7025_00066 HME7025_00066 71167 71505 - hypothetical protein gene gene-HME7025_00066 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00066 HME7025_00067 HME7025_00067 HME7025_00067 71618 71908 + hypothetical protein gene gene-HME7025_00067 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00067 HME7025_00068 HME7025_00068 HME7025_00068 71911 74958 + hypothetical protein gene gene-HME7025_00068 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00068 HME7025_00069 HME7025_00069 HME7025_00069 74958 75197 + hypothetical protein gene gene-HME7025_00069 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00069 HME7025_00070 HME7025_00070 HME7025_00070 75194 75415 + hypothetical protein gene gene-HME7025_00070 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00070 HME7025_00071 HME7025_00071 HME7025_00071 75669 75929 + hypothetical protein gene gene-HME7025_00071 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00071 HME7025_00072 HME7025_00072 HME7025_00072 75926 76477 + hypothetical protein gene gene-HME7025_00072 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00072 HME7025_00073 HME7025_00073 HME7025_00073 76499 76780 + hypothetical protein gene gene-HME7025_00073 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00073 HME7025_00074 HME7025_00074 HME7025_00074 76777 77082 + hypothetical protein gene gene-HME7025_00074 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00074 HME7025_00075 HME7025_00075 HME7025_00075 77156 77356 + hypothetical protein gene gene-HME7025_00075 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00075 HME7025_00076 HME7025_00076 HME7025_00076 77501 77854 + hypothetical protein gene gene-HME7025_00076 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00076 HME7025_00077 HME7025_00077 HME7025_00077 77851 78168 - hypothetical protein gene gene-HME7025_00077 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00077 HME7025_00078 HME7025_00078 HME7025_00078 78221 78475 + hypothetical protein gene gene-HME7025_00078 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00078 HME7025_00079 HME7025_00079 HME7025_00079 79042 79554 + hypothetical protein gene gene-HME7025_00079 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00079 HME7025_00080 HME7025_00080 HME7025_00080 79607 80131 + hypothetical protein gene gene-HME7025_00080 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00080 HME7025_00081 HME7025_00081 HME7025_00081 80135 81388 + hypothetical protein gene gene-HME7025_00081 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00081 HME7025_00082 HME7025_00082 HME7025_00082 81396 81773 + hypothetical protein gene gene-HME7025_00082 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00082 HME7025_00083 HME7025_00083 HME7025_00083 81888 82754 + hypothetical protein gene gene-HME7025_00083 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00083 HME7025_00084 HME7025_00084 HME7025_00084 82772 83230 + hypothetical protein gene gene-HME7025_00084 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00084 HME7025_00085 HME7025_00085 HME7025_00085 83278 84276 + hypothetical protein gene gene-HME7025_00085 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00085 HME7025_00086 HME7025_00086 HME7025_00086 84341 84892 + hypothetical protein gene gene-HME7025_00086 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00086 HME7025_00087 HME7025_00087 HME7025_00087 84897 85118 + hypothetical protein gene gene-HME7025_00087 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00087 HME7025_00088 HME7025_00088 HME7025_00088 85125 85319 + hypothetical protein gene gene-HME7025_00088 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00088 HME7025_00089 HME7025_00089 HME7025_00089 85420 86052 + hypothetical protein gene gene-HME7025_00089 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00089 HME7025_00090 HME7025_00090 HME7025_00090 86054 86626 + hypothetical protein gene gene-HME7025_00090 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00090 HME7025_00091 HME7025_00091 HME7025_00091 86626 88176 + hypothetical protein gene gene-HME7025_00091 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00091 HME7025_00092 HME7025_00092 HME7025_00092 88413 88670 + hypothetical protein gene gene-HME7025_00092 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00092 HME7025_00093 HME7025_00093 HME7025_00093 88676 89968 + hypothetical protein gene gene-HME7025_00093 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00093 HME7025_00094 HME7025_00094 HME7025_00094 89958 90941 + hypothetical protein gene gene-HME7025_00094 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00094 HME7025_00095 HME7025_00095 HME7025_00095 90945 91232 + hypothetical protein gene gene-HME7025_00095 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00095 HME7025_00096 HME7025_00096 HME7025_00096 91229 91519 + hypothetical protein gene gene-HME7025_00096 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00096 HME7025_00097 HME7025_00097 cwlK cwlK 91516 92019 + Peptidoglycan L-alanyl-D-glutamate endopeptidase CwlK Cell membrane%3B Cell wall biogenesis/degradation%3B Hydrolase%3B Membrane%3B Signal.%3B Cleaves the linkage of the L-alanine-D-glutamic acid of B. subtilis cell wall. Belongs to the peptidase M15C family%3B KEGG: fco:FCOL_05335 peptidoglycan L-alanyl-D-glutamate endopeptidase CwlK%3B Acting on peptide bonds (peptidases) gene gene-HME7025_00097 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00097 HME7025_00098 HME7025_00098 HME7025_00098 92049 92351 + hypothetical protein gene gene-HME7025_00098 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00098 HME7025_00099 HME7025_00099 HME7025_00099 92341 92649 + hypothetical protein gene gene-HME7025_00099 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00099 HME7025_00100 HME7025_00100 HME7025_00100 92667 93521 + hypothetical protein gene gene-HME7025_00100 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00100 HME7025_00101 HME7025_00101 HME7025_00101 93518 93985 + hypothetical protein gene gene-HME7025_00101 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00101 HME7025_00102 HME7025_00102 HME7025_00102 93988 96111 + hypothetical protein gene gene-HME7025_00102 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00102 HME7025_00103 HME7025_00103 HME7025_00103 96104 96664 + hypothetical protein gene gene-HME7025_00103 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00103 HME7025_00104 HME7025_00104 HME7025_00104 96804 97367 + hypothetical protein gene gene-HME7025_00104 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00104 HME7025_00105 HME7025_00105 HME7025_00105 97709 101437 + hypothetical protein gene gene-HME7025_00105 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00105 HME7025_00106 HME7025_00106 HME7025_00106 101437 102867 + hypothetical protein gene gene-HME7025_00106 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00106 HME7025_00107 HME7025_00107 HME7025_00107 102864 104135 - hypothetical protein gene gene-HME7025_00107 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00107 HME7025_00108 HME7025_00108 HME7025_00108 104239 104327 - tRNA-Leu tRNA gene-HME7025_00108 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00108 HME7025_00109 HME7025_00109 HME7025_00109 104368 104443 - tRNA-Gly tRNA gene-HME7025_00109 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00109 HME7025_00110 HME7025_00110 HME7025_00110 104542 105012 + Bkd operon transcriptional regulator Activator%3B DNA-binding%3B Transcription%3B Transcription regulation.%3B Positive regulator of the bkd operon for branched-chain keto acid dehydrogenase complex. Contains 1 HTH asnC-type DNA-binding domain gene gene-HME7025_00110 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00110 HME7025_00111 HME7025_00111 HME7025_00111 105013 106146 - tRNA-guanine(34) transglycosylase Glycosyltransferase%3B Metal-binding%3B Queuosine biosynthesis%3B Transferase%3B tRNA processing%3B Zinc.%3B Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp%2C -Asn%2C -His and -Tyr). After this exchange%2C a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine%2C resulting in the hypermodified nucleoside queuosine (Q) (7-(((4%2C5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)%3B Belongs to the queuine tRNA-ribosyltransferase family%3B KEGG: vei:Veis_0596 queuine tRNA-ribosyltransferase gene gene-HME7025_00111 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00111 HME7025_00112 HME7025_00112 HME7025_00112 106219 109869 - hypothetical protein gene gene-HME7025_00112 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00112 HME7025_00113 HME7025_00113 iolG iolG 109895 111007 - Inositol 2-dehydrogenase NADP%3B Oxidoreductase.%3B Catalyzes the NADP(+)-dependent oxidation of scyllo- inositol to 2%2C4%2C6/3%2C5-pentahydroxycyclohexanone (scyllo-inosose)%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: bgf:BC1003_2418 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_00113 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00113 HME7025_00114 HME7025_00114 HME7025_00114 111086 111970 - hypothetical protein gene gene-HME7025_00114 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00114 HME7025_00115 HME7025_00115 HME7025_00115 111970 113046 - hypothetical protein gene gene-HME7025_00115 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00115 HME7025_00116 HME7025_00116 HME7025_00116 113046 113444 - hypothetical protein gene gene-HME7025_00116 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00116 HME7025_00117 HME7025_00117 HME7025_00117 113555 113992 + hypothetical protein gene gene-HME7025_00117 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00117 HME7025_00118 HME7025_00118 gmhB gmhB 114015 114506 + D-glycero-beta-D-manno-heptose 1%2C7-bisphosphate 7-phosphatase Carbohydrate metabolism%3B Cytoplasm%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Zinc.%3B Converts the D-glycero-beta-D-manno-heptose 1%2C7- bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno- heptose 1-phosphate by removing the phosphate group at the C-7 position%3B Belongs to the GmhB family%3B KEGG: pgb:H744_1c0472 D-glycero-D-manno-heptose 1%2C7-bisphosphate phosphatase gene gene-HME7025_00118 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00118 HME7025_00119 HME7025_00119 HME7025_00119 114511 115416 + putative oxidoreductase YcsN NADP%3B Oxidoreductase.%3B Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: vfi:VF_A0411 null%3B With NAD(+) or NADP(+) as acceptor gene gene-HME7025_00119 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00119 HME7025_00120 HME7025_00120 vacB vacB 115459 117720 - Ribonuclease Cytoplasm%3B Exonuclease%3B Hydrolase%3B Nuclease%3B RNA-binding.%3B 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs%3B Belongs to the RNR ribonuclease family. RNase R subfamily%3B Contains 1 S1 motif domain%3B KEGG: sli:Slin_5873 ribonuclease R%3B Acting on ester bonds gene gene-HME7025_00120 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00120 HME7025_00121 HME7025_00121 HME7025_00121 117945 118955 + hypothetical protein gene gene-HME7025_00121 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00121 HME7025_00122 HME7025_00122 gcvT gcvT 118957 120045 + Aminomethyltransferase Aminotransferase%3B Transferase.%3B The glycine cleavage system catalyzes the degradation of glycine%3B Belongs to the GcvT family%3B KEGG: bbd:Belba_1969 aminomethyltransferase gene gene-HME7025_00122 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00122 HME7025_00123 HME7025_00123 comB comB 120053 120757 + 2-phosphosulfolactate phosphatase Hydrolase%3B Magnesium.%3B Belongs to the ComB family%3B KEGG: evi:Echvi_0092 2-phosphosulfolactate phosphatase gene gene-HME7025_00123 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00123 HME7025_00124 HME7025_00124 thrC thrC 120801 122108 + Threonine synthase Amino-acid biosynthesis%3B Lyase%3B Pyridoxal phosphate%3B Threonine biosynthesis.%3B Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine%3B Belongs to the threonine synthase family%3B KEGG: chu:CHU_0075 threonine synthase gene gene-HME7025_00124 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00124 HME7025_00125 HME7025_00125 HME7025_00125 122221 122583 - hypothetical protein gene gene-HME7025_00125 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00125 HME7025_00126 HME7025_00126 HME7025_00126 122722 124059 - hypothetical protein gene gene-HME7025_00126 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00126 HME7025_00127 HME7025_00127 HME7025_00127 124078 125664 - hypothetical protein gene gene-HME7025_00127 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00127 HME7025_00128 HME7025_00128 arnC arnC 125665 126456 - Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Glycosyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Lipopolysaccharide biosynthesis%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides%3B Belongs to the glycosyltransferase 2 family%3B KEGG: pmr:PMI1044 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase gene gene-HME7025_00128 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00128 HME7025_00129 HME7025_00129 rfbB rfbB 126407 127471 - dTDP-glucose 4%2C6-dehydratase Isomerase%3B Lipopolysaccharide biosynthesis.%3B Catalyzes the isomeration of CDP-paratose to CDP- tyvelose. Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: lcb:LCABL_21800 dTDP-glucose 4%2C6-dehydratase gene gene-HME7025_00129 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00129 HME7025_00130 HME7025_00130 rfbE rfbE 127471 128526 - CDP-paratose 2-epimerase Carbohydrate metabolism%3B Galactose metabolism%3B Isomerase%3B NAD.%3B Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: rsh:Rsph17029_3699 CDP-paratose 2-epimerase gene gene-HME7025_00130 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00130 HME7025_00131 HME7025_00131 HME7025_00131 128765 129475 - hypothetical protein gene gene-HME7025_00131 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00131 HME7025_00132 HME7025_00132 HME7025_00132 129526 129843 - hypothetical protein gene gene-HME7025_00132 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00132 HME7025_00133 HME7025_00133 HME7025_00133 129938 130195 - hypothetical protein gene gene-HME7025_00133 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00133 HME7025_00134 HME7025_00134 HME7025_00134 130185 130559 - hypothetical protein gene gene-HME7025_00134 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00134 HME7025_00135 HME7025_00135 yicI yicI 130746 132896 + Alpha-D-xyloside xylohydrolase Glycosidase%3B Hydrolase.%3B Belongs to the glycosyl hydrolase 31 family%3B KEGG: rsi:Runsl_4255 alpha-D-xyloside xylohydrolase gene gene-HME7025_00135 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00135 HME7025_00136 HME7025_00136 HME7025_00136 132909 133787 + hypothetical protein gene gene-HME7025_00136 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00136 HME7025_00137 HME7025_00137 HME7025_00137 133805 134491 - hypothetical protein gene gene-HME7025_00137 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00137 HME7025_00138 HME7025_00138 HME7025_00138 134488 134838 - hypothetical protein gene gene-HME7025_00138 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00138 HME7025_00139 HME7025_00139 HME7025_00139 134952 135593 + Protein disulfide-isomerase KEGG: bcz:BCZK0249 protein disulfide-isomerase gene gene-HME7025_00139 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00139 HME7025_00140 HME7025_00140 hemN hemN 135714 137078 + Coproporphyrinogen dehydrogenase 4Fe-4S%3B Bacteriochlorophyll biosynthesis%3B Chlorophyll biosynthesis%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Porphyrin biosynthesis%3B S-adenosyl-L-methionine.%3B Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX. Dedicated to bacteriochlorophyll biosynthesis. Belongs to the anaerobic coproporphyrinogen-III oxidase family%3B KEGG: rsi:Runsl_5252 oxygen-independent coproporphyrinogen III oxidase gene gene-HME7025_00140 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00140 HME7025_00141 HME7025_00141 HME7025_00141 137146 137679 + hypothetical protein gene gene-HME7025_00141 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00141 HME7025_00142 HME7025_00142 HME7025_00142 137667 138140 + hypothetical protein gene gene-HME7025_00142 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00142 HME7025_00143 HME7025_00143 cyaA cyaA 138108 138674 - Adenylate cyclase Antibiotic resistance%3B Plasmid.%3B Together with proteins McbE and McbF this protein causes immunity to the peptide antibiotic microcin B17 (MccB17)%2C which inhibits DNA replication in Enterobacteriaceae by induction of the SOS repair system. McbG alone can provide some protection%3B Belongs to the pentapeptide repeat protein family%3B KEGG: dhy:DESAM_20197 adenylate cyclase%2C class 1 gene gene-HME7025_00143 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00143 HME7025_00144 HME7025_00144 HME7025_00144 138805 139524 + hypothetical protein gene gene-HME7025_00144 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00144 HME7025_00145 HME7025_00145 HME7025_00145 139534 140925 + hypothetical protein gene gene-HME7025_00145 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00145 HME7025_00146 HME7025_00146 HME7025_00146 140971 144141 + hypothetical protein gene gene-HME7025_00146 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00146 HME7025_00147 HME7025_00147 HME7025_00147 144146 145630 + hypothetical protein gene gene-HME7025_00147 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00147 HME7025_00148 HME7025_00148 HME7025_00148 145656 147302 + hypothetical protein gene gene-HME7025_00148 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00148 HME7025_00149 HME7025_00149 chlI chlI 147680 149116 - Magnesium chelatase KEGG: cgl:NCgl1012 magnesium chelatase subunit I gene gene-HME7025_00149 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00149 HME7025_00150 HME7025_00150 HME7025_00150 149129 150247 - hypothetical protein gene gene-HME7025_00150 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00150 HME7025_00151 HME7025_00151 erg3 erg3 150321 151151 + Delta(7)-sterol 5(6)-desaturase Endoplasmic reticulum%3B Iron%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B NAD%3B Oxidoreductase%3B Steroid biosynthesis%3B Steroid metabolism%3B Sterol biosynthesis%3B Sterol metabolism%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the first step in the removal of the two C-4 methyl groups of 4%2C4-dimethylzymosterol%3B Belongs to the sterol desaturase family%3B KEGG: tms:TREMEDRAFT_45020 delta7-sterol 5-desaturase gene gene-HME7025_00151 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00151 HME7025_00152 HME7025_00152 HME7025_00152 151162 152082 + hypothetical protein gene gene-HME7025_00152 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00152 HME7025_00153 HME7025_00153 HME7025_00153 152079 153008 - hypothetical protein gene gene-HME7025_00153 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00153 HME7025_00154 HME7025_00154 HME7025_00154 153005 153808 - hypothetical protein gene gene-HME7025_00154 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00154 HME7025_00155 HME7025_00155 HME7025_00155 153938 156934 - hypothetical protein gene gene-HME7025_00155 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00155 HME7025_00156 HME7025_00156 HME7025_00156 157197 157949 + hypothetical protein gene gene-HME7025_00156 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00156 HME7025_00157 HME7025_00157 HME7025_00157 158091 159110 + Alpha-L-rhamnosidase KEGG: nko:Niako_3601 alpha-L-rhamnosidase gene gene-HME7025_00157 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00157 HME7025_00158 HME7025_00158 HME7025_00158 159112 160614 + Putative sodium-dependent multivitamin transporter Glycoprotein%3B Ion transport%3B Membrane%3B Sodium%3B Sodium transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene-HME7025_00158 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00158 HME7025_00159 HME7025_00159 dapA dapA 160623 161564 + 4-hydroxy-tetrahydrodipicolinate synthase Cytoplasm%3B Lyase%3B Plasmid%3B Schiff base.%3B Upon expression in E. coli complements a dapA deletion mutation%2C but this may not be its physiological function. Belongs to the DapA family%3B KEGG: dfe:Dfer_3986 4-hydroxy-tetrahydrodipicolinate synthase gene gene-HME7025_00159 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00159 HME7025_00160 HME7025_00160 HME7025_00160 161561 162346 - Chitin deacetylase Hydrolase%3B Signal.%3B Belongs to the polysaccharide deacetylase family%3B KEGG: gtn:GTNG_3405 chitin deacetylase gene gene-HME7025_00160 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00160 HME7025_00161 HME7025_00161 HME7025_00161 162348 163643 - hypothetical protein gene gene-HME7025_00161 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00161 HME7025_00162 HME7025_00162 HME7025_00162 163687 164550 - putative transcriptional regulator LumQ DNA-binding%3B Transcription%3B Transcription regulation.%3B Probable transcriptional regulator. Its target gene(s) is not yet known. Contains 1 HTH araC/xylS-type DNA-binding domain gene gene-HME7025_00162 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00162 HME7025_00163 HME7025_00163 HME7025_00163 164741 168112 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_00163 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00163 HME7025_00164 HME7025_00164 HME7025_00164 168139 169779 + hypothetical protein gene gene-HME7025_00164 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00164 HME7025_00165 HME7025_00165 HME7025_00165 169845 171143 + hypothetical protein gene gene-HME7025_00165 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00165 HME7025_00166 HME7025_00166 chbG chbG 171224 172306 + Chitin disaccharide deacetylase Carbohydrate metabolism%3B Hydrolase%3B Magnesium%3B Metal-binding.%3B Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides%3B Belongs to the YdjC deacetylase family%3B KEGG: dfe:Dfer_3997 chitin disaccharide deacetylase gene gene-HME7025_00166 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00166 HME7025_00167 HME7025_00167 HME7025_00167 172311 173492 + hypothetical protein gene gene-HME7025_00167 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00167 HME7025_00168 HME7025_00168 HME7025_00168 173517 175754 + hypothetical protein gene gene-HME7025_00168 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00168 HME7025_00169 HME7025_00169 glpQ glpQ 175808 176644 - Glycerophosphodiester phosphodiesterase Hydrolase.%3B Contains 1 GP-PDE domain%3B To glycerophosphoryl diester phosphodiesterases (EC 3. 1. 4. 46)%3B To M. genitalium MG385%3B KEGG: csa:Csal_2061 glycerophosphoryl diester phosphodiesterase gene gene-HME7025_00169 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00169 HME7025_00170 HME7025_00170 HME7025_00170 176985 178139 + hypothetical protein gene gene-HME7025_00170 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00170 HME7025_00171 HME7025_00171 HME7025_00171 178302 178664 + hypothetical protein gene gene-HME7025_00171 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00171 HME7025_00172 HME7025_00172 HME7025_00172 178695 181187 - hypothetical protein gene gene-HME7025_00172 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00172 HME7025_00173 HME7025_00173 HME7025_00173 181369 182868 + hypothetical protein gene gene-HME7025_00173 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00173 HME7025_00174 HME7025_00174 HME7025_00174 182930 183544 + hypothetical protein gene gene-HME7025_00174 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00174 HME7025_00175 HME7025_00175 agmO agmO 183632 184453 + Alkylglycerol monooxygenase KEGG: mdo:100022353 alkylglycerol monooxygenase gene gene-HME7025_00175 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00175 HME7025_00176 HME7025_00176 HME7025_00176 184450 186009 - 6-phosphogluconolactonase Acetylation%3B Carbohydrate metabolism%3B Glucose metabolism%3B Hydrolase.%3B Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate%3B Belongs to the cycloisomerase 2 family%3B KEGG: cml:BN424_759 6-phosphogluconolactonase gene gene-HME7025_00176 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00176 HME7025_00177 HME7025_00177 HME7025_00177 186102 186950 + Chitin disaccharide deacetylase Carbohydrate metabolism%3B Hydrolase%3B Magnesium%3B Metal-binding.%3B Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides%3B Belongs to the YdjC deacetylase family%3B KEGG: srd:SD10_22185 chitin disaccharide deacetylase gene gene-HME7025_00177 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00177 HME7025_00178 HME7025_00178 HME7025_00178 187077 187859 + hypothetical protein gene gene-HME7025_00178 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00178 HME7025_00179 HME7025_00179 HME7025_00179 187863 188852 + D-threo-aldose 1-dehydrogenase NADP%3B Oxidoreductase.%3B Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: hba:Hbal_2682 D-threo-aldose 1-dehydrogenase gene gene-HME7025_00179 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00179 HME7025_00180 HME7025_00180 gatA gatA 189025 190683 + Asparaginyl-tRNA synthase (glutamine-hydrolyzing) Hydrolase.%3B Belongs to the amidase family%3B KEGG: bpe:BP3426 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A gene gene-HME7025_00180 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00180 HME7025_00181 HME7025_00181 HME7025_00181 190805 191620 + hypothetical protein gene gene-HME7025_00181 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00181 HME7025_00182 HME7025_00182 HME7025_00182 191622 192818 + Inositol 2-dehydrogenase Carbohydrate metabolism%3B NAD%3B NADP%3B Oxidoreductase%3B Plasmid.%3B Catalyzes the NADP(+)-dependent oxidation of D-xylose. Is able to use both NADP(+) and NAD(+%3B however%2C the enzyme shows a very strong preference for NADP(+). Is likely involved in the first step of the oxidative D-xylose degradation pathway%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: art:Arth_0833 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_00182 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00182 HME7025_00183 HME7025_00183 yihV yihV 192818 193714 + Sulfofructose kinase Alternative splicing%3B ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: enc:ECL_05102 sulfofructose kinase gene gene-HME7025_00183 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00183 HME7025_00184 HME7025_00184 urh1 urh1 193711 194658 + Uridine nucleosidase KEGG: eus:EUTSA_v10016893mg uridine nucleosidase gene gene-HME7025_00184 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00184 HME7025_00185 HME7025_00185 HME7025_00185 194663 196207 + hypothetical protein gene gene-HME7025_00185 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00185 HME7025_00186 HME7025_00186 HME7025_00186 196226 197224 + Ureide permease ATP-binding%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Proton-coupled transporter that transports a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds%2C including allantoin%2C uric acid and xanthine%2C but not adenine (PubMed:11971139%2C PubMed:15308648). Mediates high affinity transport of uracil and 5-fluorouracil (a toxic uracil analog) (PubMed:15308648%2C PubMed:16897711). Mediates transport of free pyrimidines and may function during early seedling development in salvage pathways%2C by the utilization of pyrimidines from seed storage tissue (PubMed:15308648)%3B Belongs to the plant ureide permease (TC 2. A. 7. 19) family gene gene-HME7025_00186 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00186 HME7025_00187 HME7025_00187 HME7025_00187 197248 198066 + hypothetical protein gene gene-HME7025_00187 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00187 HME7025_00188 HME7025_00188 HME7025_00188 198089 198538 + hypothetical protein gene gene-HME7025_00188 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00188 HME7025_00189 HME7025_00189 arsA arsA 198592 200058 + Cerebroside-sulfatase Alternative splicing%3B Calcium%3B Glycoprotein%3B Hydrolase%3B Lysosome%3B Metal-binding%3B Polymorphism%3B Signal.%3B Belongs to the sulfatase family%3B KEGG: mgp:100539178 arylsulfatase A gene gene-HME7025_00189 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00189 HME7025_00190 HME7025_00190 arsG arsG 200061 201440 + Arylsulfatase Alternative splicing%3B Calcium%3B Glycoprotein%3B Hydrolase%3B Lysosome%3B Metal-binding%3B Polymorphism%3B Signal.%3B Belongs to the sulfatase family%3B KEGG: cge:100751256 arylsulfatase G%3B Sulfuric ester hydrolases gene gene-HME7025_00190 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00190 HME7025_00191 HME7025_00191 HME7025_00191 201501 203210 - hypothetical protein gene gene-HME7025_00191 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00191 HME7025_00192 HME7025_00192 yteR yteR 203217 204359 - Unsaturated rhamnogalacturonyl hydrolase Cytoplasm%3B Glycosidase%3B Hydrolase.%3B Catalyzes the hydrolysis of unsaturated rhamnogalacturonan disaccharide to yield unsaturated D- galacturonic acid and L-rhamnose. It cannot act on unsaturated glucuronyl hydrolase (UGL) substrates containing unsaturated D- glucuronic acid at the non-reducing terminus%2C although the active pockets of YesR and UGL are very similar%3B Belongs to the glycosyl hydrolase 105 family%3B KEGG: bho:D560_1661 unsaturated rhamnogalacturonyl hydrolase gene gene-HME7025_00192 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00192 HME7025_00193 HME7025_00193 HME7025_00193 204502 205002 - hypothetical protein gene gene-HME7025_00193 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00193 HME7025_00194 HME7025_00194 HME7025_00194 205397 206281 + UPF0750 membrane protein YdeO Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0750 family gene gene-HME7025_00194 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00194 HME7025_00195 HME7025_00195 HME7025_00195 206581 207234 - hypothetical protein gene gene-HME7025_00195 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00195 HME7025_00196 HME7025_00196 HME7025_00196 207362 229765 - Glycoprotein gp2 Glycoprotein%3B Membrane%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Virion%3B Virulence.%3B Virulence factor gene gene-HME7025_00196 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00196 HME7025_00197 HME7025_00197 HME7025_00197 230092 230307 + hypothetical protein gene gene-HME7025_00197 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00197 HME7025_00198 HME7025_00198 HME7025_00198 230421 231896 - hypothetical protein gene gene-HME7025_00198 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00198 HME7025_00199 HME7025_00199 HME7025_00199 231901 232974 - Peptidylglycine monooxygenase KEGG: rba:RB9882 peptidylglycine monooxygenase gene gene-HME7025_00199 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00199 HME7025_00200 HME7025_00200 HME7025_00200 232999 235788 - hypothetical protein gene gene-HME7025_00200 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00200 HME7025_00201 HME7025_00201 HME7025_00201 235785 237254 - hypothetical protein gene gene-HME7025_00201 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00201 HME7025_00202 HME7025_00202 HME7025_00202 237259 238629 - Alpha-ketoglutarate permease Cell inner membrane%3B Cell membrane%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system)%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene-HME7025_00202 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00202 HME7025_00203 HME7025_00203 HME7025_00203 238806 239825 + Catabolite control protein Activator%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation.%3B Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA)%2C which ensures optimal energy usage under diverse conditions%3B Contains 1 HTH lacI-type DNA-binding domain gene gene-HME7025_00203 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00203 HME7025_00204 HME7025_00204 HME7025_00204 239940 243035 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_00204 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00204 HME7025_00205 HME7025_00205 HME7025_00205 243049 244716 + hypothetical protein gene gene-HME7025_00205 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00205 HME7025_00206 HME7025_00206 HME7025_00206 245000 245602 + hypothetical protein gene gene-HME7025_00206 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00206 HME7025_00207 HME7025_00207 HME7025_00207 245626 247344 + Gluconate 2-dehydrogenase (acceptor) Cell membrane%3B FAD%3B Flavoprotein%3B Membrane%3B Oxidoreductase.%3B Catalytic subunit of fructose dehydrogenase%2C an enzyme that catalyzes the oxidation of D-fructose to produce 5-keto-D- fructose%3B Belongs to the GMC oxidoreductase family%3B KEGG: htu:Htur_1314 gluconate 2-dehydrogenase alpha chain gene gene-HME7025_00207 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00207 HME7025_00208 HME7025_00208 HME7025_00208 247509 248693 + hypothetical protein gene gene-HME7025_00208 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00208 HME7025_00209 HME7025_00209 HME7025_00209 248688 249791 - DNA replication and repair protein RecF ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA repair%3B DNA replication%3B DNA-binding%3B Nucleotide-binding%3B SOS response.%3B The RecF protein is involved in DNA metabolis%3B it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded%2C linear DNA. It also seems to bind ATP%3B Belongs to the RecF family gene gene-HME7025_00209 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00209 HME7025_00210 HME7025_00210 pdhA pdhA 249972 250982 + Pyruvate dehydrogenase (acetyl-transferring) Glycolysis%3B Oxidoreductase%3B Pyruvate%3B Thiamine pyrophosphate.%3B The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B KEGG: pko:PKOR_03220 pyruvate dehydrogenase E1 component alpha subunit gene gene-HME7025_00210 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00210 HME7025_00211 HME7025_00211 HME7025_00211 251044 253068 - UvrABC system protein ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA excision%3B DNA repair%3B Excision nuclease%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B SOS response.%3B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site%2C the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix%2C facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found%2C the DNA wraps around the other UvrB subunit that will check the other stand for damage%3B Belongs to the UvrB family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 UVR domain gene gene-HME7025_00211 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00211 HME7025_00212 HME7025_00212 HME7025_00212 253147 254010 + Licheninase Glycosidase%3B Hydrolase%3B Signal.%3B Shows activity on lichenan%2C beta-glucan and laminarin but not on CMC cellulose or xylan. Belongs to the glycosyl hydrolase 16 family%3B Contains 1 GH16 (glycosyl hydrolase family 16) domain%3B KEGG: sru:SRU_2844 licheninase gene gene-HME7025_00212 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00212 HME7025_00213 HME7025_00213 HME7025_00213 254225 255049 + Licheninase Glycosidase%3B Hydrolase%3B Signal.%3B Shows activity on lichenan%2C beta-glucan and laminarin but not on CMC cellulose or xylan. Belongs to the glycosyl hydrolase 16 family%3B Contains 1 GH16 (glycosyl hydrolase family 16) domain%3B KEGG: sru:SRU_2844 licheninase gene gene-HME7025_00213 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00213 HME7025_00214 HME7025_00214 rdgB rdgB 255051 255851 + XTP/dITP diphosphatase ATP-binding%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding.%3B Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs%2C as well as the mutagenic dUTP and 8-oxo-7%2C8- dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP). Also involved in the transcriptional activation of RelA in response to oxidative stress%3B Belongs to the nucleoside triphosphate pyrophosphohydrolase family%3B KEGG: psn:Pedsa_2109 XTP/dITP diphosphohydrolase gene gene-HME7025_00214 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00214 HME7025_00215 HME7025_00215 galM galM 255904 257052 - Aldose 1-epimerase Carbohydrate metabolism%3B Cytoplasm%3B Isomerase%3B Phosphoprotein.%3B Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose (By similarity)%3B Belongs to the aldose epimerase family%3B KEGG: zmo:ZMO0889 aldose 1-epimerase gene gene-HME7025_00215 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00215 HME7025_00216 HME7025_00216 HME7025_00216 257161 259032 + 30S ribosomal protein S1 Repeat%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding.%3B Binds mRN%3B thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)%3B Belongs to the ribosomal protein S1P family%3B Contains 6 S1 motif domains gene gene-HME7025_00216 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00216 HME7025_00217 HME7025_00217 HME7025_00217 259272 260705 + scyllo-inositol 2-dehydrogenase (NAD(+)) NAD%3B Oxidoreductase.%3B Catalyzes the NAD(+)-dependent oxidation of scyllo- inositol to 2%2C4%2C6/3%2C5-pentahydroxycyclohexanone (scyllo-inosose)%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: gfo:GFO_1545 null%3B Oxidoreductases gene gene-HME7025_00217 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00217 HME7025_00218 HME7025_00218 manC manC 260786 261295 + Mannose-1-phosphate guanylyltransferase KEGG: nga:Ngar_c00660 mannose-1-phosphate guanylyltransferase gene gene-HME7025_00218 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00218 HME7025_00219 HME7025_00219 HME7025_00219 261412 262011 + hypothetical protein gene gene-HME7025_00219 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00219 HME7025_00220 HME7025_00220 HME7025_00220 262013 263353 + hypothetical protein gene gene-HME7025_00220 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00220 HME7025_00221 HME7025_00221 HME7025_00221 263376 264488 + uncharacterized protein Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene-HME7025_00221 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00221 HME7025_00222 HME7025_00222 HME7025_00222 264507 267932 + Protein HelA Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Presumed to function with HelC and HelB in efflux of an unidentified substrate. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene-HME7025_00222 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00222 HME7025_00223 HME7025_00223 HME7025_00223 268216 269904 + Gamma-glutamyltransferase Acyltransferase%3B Glutathione biosynthesis%3B Hydrolase%3B Protease%3B Secreted%3B Signal%3B Transferase%3B Zymogen.%3B Belongs to the gamma-glutamyltransferase family%3B KEGG: doi:FH5T_18810 gamma-glutamyltranspeptidase / glutathione hydrolase gene gene-HME7025_00223 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00223 HME7025_00224 HME7025_00224 nagA nagA 269914 271005 + N-acetylglucosamine-6-phosphate deacetylase Carbohydrate metabolism%3B Hydrolase%3B Metal-binding.%3B Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: gni:GNIT_0144 N-acetylglucosamine-6-phosphate deacetylase gene gene-HME7025_00224 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00224 HME7025_00225 HME7025_00225 ybdL ybdL 271007 272152 + Methionine aminotransferase Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase.%3B Shows aminotransferase activity with methionine and histidine as substrates%2C and to a lesser extent also with phenylalanine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: ecg:E2348C_0503 methionine aminotransferase%3B Transaminases gene gene-HME7025_00225 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00225 HME7025_00226 HME7025_00226 glxK glxK 272147 273298 - Glycerate 3-kinase ATP-binding%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Belongs to the glycerate kinase type-1 family%3B KEGG: vvy:VVA1391 glycerate kinase gene gene-HME7025_00226 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00226 HME7025_00227 HME7025_00227 HME7025_00227 273367 273756 + hypothetical protein gene gene-HME7025_00227 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00227 HME7025_00228 HME7025_00228 HME7025_00228 273757 274095 - uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_00228 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00228 HME7025_00229 HME7025_00229 hisI hisI 274097 274693 - Phosphoribosyl-AMP cyclohydrolase Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Zinc.%3B Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP%3B Belongs to the PRA-CH family%3B KEGG: dds:Ddes_0361 phosphoribosyl-AMP cyclohydrolase gene gene-HME7025_00229 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00229 HME7025_00230 HME7025_00230 hisF hisF 274719 275474 - Imidazole glycerol phosphate synthase subunit HisF Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Lyase.%3B IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit%3B Belongs to the HisA/HisF family%3B KEGG: xfa:XF2214 cyclase%3B Oxo-acid-lyases gene gene-HME7025_00230 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00230 HME7025_00231 HME7025_00231 hisA hisA 275468 276202 - 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Isomerase.%3B Belongs to the HisA/HisF family%3B KEGG: cje:Cj1601 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase gene gene-HME7025_00231 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00231 HME7025_00232 HME7025_00232 hisH hisH 276206 276793 - Imidazole glycerol phosphate synthase subunit HisH Amino-acid biosynthesis%3B Cytoplasm%3B Glutamine amidotransferase%3B Histidine biosynthesis%3B Transferase.%3B IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: sbu:SpiBuddy_0668 glutamine amidotransferase%3B Pentosyltransferases gene gene-HME7025_00232 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00232 HME7025_00233 HME7025_00233 HME7025_00233 276934 277557 + hypothetical protein gene gene-HME7025_00233 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00233 HME7025_00234 HME7025_00234 rhlE rhlE 277663 278901 + RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Nucleus%3B Ribosome biogenesis%3B RNA-binding%3B rRNA processing.%3B ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0%2C A1 and A2 sites. Required for vegetative growth (By similarity)%3B Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mpt:Mpe_A2088 ATP-dependent RNA helicase RhlE gene gene-HME7025_00234 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00234 HME7025_00235 HME7025_00235 iolW iolW 278906 280303 - Scyllo-inositol 2-dehydrogenase (NADP(+)) Glycosidase%3B Hydrolase%3B NAD%3B Signal.%3B Glycosidase%3B Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily%3B KEGG: plu:plu2375 scyllo-inositol 2-dehydrogenase (NADP+) gene gene-HME7025_00235 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00235 HME7025_00236 HME7025_00236 HME7025_00236 280328 280723 - hypothetical protein gene gene-HME7025_00236 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00236 HME7025_00237 HME7025_00237 HME7025_00237 280770 281453 + hypothetical protein gene gene-HME7025_00237 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00237 HME7025_00238 HME7025_00238 gpmI gpmI 281505 283025 + Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Glycolysis%3B Isomerase%3B Manganese%3B Metal-binding.%3B Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate%3B Belongs to the BPG-independent phosphoglycerate mutase family%3B KEGG: mhy:mhp615 2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase gene gene-HME7025_00238 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00238 HME7025_00239 HME7025_00239 HME7025_00239 283081 283740 + hypothetical protein gene gene-HME7025_00239 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00239 HME7025_00240 HME7025_00240 HME7025_00240 283903 284220 - hypothetical protein gene gene-HME7025_00240 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00240 HME7025_00241 HME7025_00241 HME7025_00241 284225 285502 - Phosphopyruvate hydratase Cytoplasm%3B Glycolysis%3B Lyase%3B Magnesium%3B Metal-binding%3B Secreted.%3B Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis%3B Belongs to the enolase family%3B KEGG: mcd:MCRO_0018 enolase gene gene-HME7025_00241 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00241 HME7025_00242 HME7025_00242 HME7025_00242 285640 286359 + Thioredoxin Disulfide bond%3B Electron transport%3B Redox-active center%3B Transport.%3B Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene-HME7025_00242 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00242 HME7025_00243 HME7025_00243 HME7025_00243 286340 287311 - hypothetical protein gene gene-HME7025_00243 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00243 HME7025_00244 HME7025_00244 HME7025_00244 287600 287965 + hypothetical protein gene gene-HME7025_00244 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00244 HME7025_00245 HME7025_00245 HME7025_00245 288217 288546 - hypothetical protein gene gene-HME7025_00245 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00245 HME7025_00246 HME7025_00246 HME7025_00246 288551 288868 - hypothetical protein gene gene-HME7025_00246 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00246 HME7025_00247 HME7025_00247 HME7025_00247 289092 290186 - hypothetical protein gene gene-HME7025_00247 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00247 HME7025_00248 HME7025_00248 HME7025_00248 290223 290975 - hypothetical protein gene gene-HME7025_00248 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00248 HME7025_00249 HME7025_00249 HME7025_00249 291244 292104 + hypothetical protein gene gene-HME7025_00249 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00249 HME7025_00250 HME7025_00250 HME7025_00250 292101 292829 - hypothetical protein gene gene-HME7025_00250 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00250 HME7025_00251 HME7025_00251 wapR wapR 292831 293817 - Putative glycosyltransferase EpsE Exopolysaccharide synthesis%3B Glycosyltransferase%3B Transferase.%3B May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Required for biofilm maintenance. Belongs to the glycosyltransferase 2 family%3B KEGG: pae:PA5000 alpha-1%2C3-rhamnosyltransferase%3B Hexosyltransferases gene gene-HME7025_00251 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00251 HME7025_00252 HME7025_00252 gidB gidB 293858 294484 - 16S rRNA (guanine(527)-N(7))-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase.%3B Specifically methylates the N7 position of a guanine in 16S rRNA%3B Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family%3B KEGG: ndo:DDD_1857 16S rRNA (guanine527-N7)-methyltransferase gene gene-HME7025_00252 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00252 HME7025_00253 HME7025_00253 HME7025_00253 294522 295349 - hypothetical protein gene gene-HME7025_00253 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00253 HME7025_00254 HME7025_00254 HME7025_00254 295410 296867 - putative low-affinity inorganic phosphate transporter Cell membrane%3B Membrane%3B Phosphate transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Low-affinity inorganic phosphate transport%3B Belongs to the inorganic phosphate transporter (PiT) (TC 2. A. 20) family. Pit subfamily gene gene-HME7025_00254 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00254 HME7025_00255 HME7025_00255 HME7025_00255 296956 298188 - hypothetical protein gene gene-HME7025_00255 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00255 HME7025_00256 HME7025_00256 cafA cafA 298160 299716 - Ribonuclease Cell cycle%3B Cell division%3B Cytoplasm%3B Cytoskeleton%3B Endonuclease%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease.%3B Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure (By similarity)%3B Belongs to the RNase E/G family. RNase G subfamily%3B Contains 1 S1 motif domain%3B KEGG: xfa:XF1125 ribonuclease G%3B Endoribonucleases producing 5'-phosphomonoesters gene gene-HME7025_00256 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00256 HME7025_00257 HME7025_00257 HME7025_00257 299997 300863 - hypothetical protein gene gene-HME7025_00257 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00257 HME7025_00258 HME7025_00258 HME7025_00258 300889 301182 - Integration host factor subunit alpha DNA recombination%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Translation regulation.%3B This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control%3B Belongs to the bacterial histone-like protein family gene gene-HME7025_00258 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00258 HME7025_00259 HME7025_00259 mutY mutY 301323 302456 + putative A/G-specific adenine glycosylase YfhQ 4Fe-4S%3B DNA damage%3B DNA repair%3B Glycosidase%3B Hydrolase%3B Iron%3B Iron-sulfur%3B Metal-binding.%3B Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7%2C8-dihydro-8-oxoguanine%2C 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A. T to G. C transversions (By similarity). Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7%2C8-dihydro-8- oxoguanine (By similarity)%3B Belongs to the Nth/MutY family%3B Contains 1 HhH domain%3B KEGG: lia:JL58_08960 A/G-specific adenine glycosylase%3B Hydrolyzing N-glycosyl compounds gene gene-HME7025_00259 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00259 HME7025_00260 HME7025_00260 HME7025_00260 302506 302970 + Plasmid-derived single-stranded DNA-binding protein DNA replication%3B DNA-binding%3B Plasmid.%3B May contribute to the conjugative processing of DNA. It has a functional relationship with Psi (plasmid-mediated sos inhibition) proteins%3B Contains 1 SSB domain gene gene-HME7025_00260 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00260 HME7025_00261 HME7025_00261 HME7025_00261 303047 304405 + Hemolysin CBS domain%3B Cytolysis%3B Hemolysis%3B Repeat%3B Toxin.%3B Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. Belongs to the UPF0053 family%3B Contains 2 CBS domains gene gene-HME7025_00261 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00261 HME7025_00262 HME7025_00262 HME7025_00262 304389 305345 + hypothetical protein gene gene-HME7025_00262 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00262 HME7025_00263 HME7025_00263 HME7025_00263 305342 306283 + hypothetical protein gene gene-HME7025_00263 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00263 HME7025_00264 HME7025_00264 uvrD uvrD 306285 308561 - DNA helicase ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding.%3B DNA-dependent ATPase%2C stimulated equally by ss-and dsDNA. Has both ATPase and helicase activities (By similarity)%3B Belongs to the helicase family. UvrD subfamily%3B Contains 1 HRDC domain%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: syw:SYNW0181 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene-HME7025_00264 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00264 HME7025_00265 HME7025_00265 HME7025_00265 308713 309066 - hypothetical protein gene gene-HME7025_00265 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00265 HME7025_00266 HME7025_00266 HME7025_00266 309412 312249 + hypothetical protein gene gene-HME7025_00266 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00266 HME7025_00267 HME7025_00267 HME7025_00267 312284 314056 + hypothetical protein gene gene-HME7025_00267 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00267 HME7025_00268 HME7025_00268 HME7025_00268 314102 314647 + hypothetical protein gene gene-HME7025_00268 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00268 HME7025_00269 HME7025_00269 HME7025_00269 314676 315053 + hypothetical protein gene gene-HME7025_00269 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00269 HME7025_00270 HME7025_00270 HME7025_00270 315170 318379 + Protein oar Cell outer membrane%3B Membrane%3B Signal. gene gene-HME7025_00270 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00270 HME7025_00271 HME7025_00271 HME7025_00271 318567 319841 - hypothetical protein gene gene-HME7025_00271 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00271 HME7025_00272 HME7025_00272 HME7025_00272 319838 320383 - Gamma-butyrobetaine dioxygenase Hydrolase.%3B Contains 1 HD domain%3B KEGG: kal:KALB_3391 gamma-butyrobetaine dioxygenase gene gene-HME7025_00272 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00272 HME7025_00273 HME7025_00273 phnO phnO 320489 320929 + Protein PhnO Acyltransferase%3B Alkylphosphonate uptake%3B Transferase.%3B Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. Contains 1 N-acetyltransferase domain%3B KEGG: hav:AT03_03605 PhnO protein%3B Transferring groups other than amino-acyl groups gene gene-HME7025_00273 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00273 HME7025_00274 HME7025_00274 phoA phoA 320920 321996 - Alkaline phosphatase Hydrolase%3B Magnesium%3B Metal-binding%3B Phosphoprotein%3B Signal%3B Zinc.%3B Belongs to the alkaline phosphatase family%3B KEGG: taf:THA_489 alkaline phosphatase gene gene-HME7025_00274 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00274 HME7025_00275 HME7025_00275 HME7025_00275 322003 323148 - hypothetical protein gene gene-HME7025_00275 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00275 HME7025_00276 HME7025_00276 phnX phnX 323135 323881 - Phosphonoacetaldehyde hydrolase KEGG: emu:EMQU_1817 phosphonoacetaldehyde hydrolase gene gene-HME7025_00276 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00276 HME7025_00277 HME7025_00277 HME7025_00277 324333 327569 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_00277 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00277 HME7025_00278 HME7025_00278 HME7025_00278 327603 329189 + hypothetical protein gene gene-HME7025_00278 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00278 HME7025_00279 HME7025_00279 HME7025_00279 329254 329631 - hypothetical protein gene gene-HME7025_00279 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00279 HME7025_00280 HME7025_00280 HME7025_00280 329729 330916 - hypothetical protein gene gene-HME7025_00280 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00280 HME7025_00281 HME7025_00281 HME7025_00281 330918 331721 - hypothetical protein gene gene-HME7025_00281 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00281 HME7025_00282 HME7025_00282 coaX coaX 332022 332750 - Pantothenate kinase ATP-binding%3B Coenzyme A biosynthesis%3B Cytoplasm%3B Kinase%3B Metal-binding%3B Nucleotide-binding%3B Potassium%3B Transferase.%3B Catalyzes the phosphorylation of pantothenate (Pan)%2C the first step in CoA biosynthesis%3B Belongs to the type III pantothenate kinase family%3B KEGG: nko:Niako_6548 type III pantothenate kinase gene gene-HME7025_00282 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00282 HME7025_00283 HME7025_00283 panD panD 332850 333170 + Aspartate 1-decarboxylase Autocatalytic cleavage%3B Cytoplasm%3B Decarboxylase%3B Lyase%3B Pantothenate biosynthesis%3B Pyruvate%3B Schiff base%3B Zymogen.%3B Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine%3B Belongs to the PanD family%3B KEGG: mct:MCR_0854 aspartate 1-decarboxylase gene gene-HME7025_00283 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00283 HME7025_00284 HME7025_00284 panB panB 333167 333982 - 3-methyl-2-oxobutanoate hydroxymethyltransferase Cytoplasm%3B Magnesium%3B Metal-binding%3B Pantothenate biosynthesis%3B Transferase.%3B Catalyzes the reversible reaction in which hydroxymethyl group from 5%2C10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate%3B Belongs to the PanB family%3B KEGG: fjo:Fjoh_4711 3-methyl-2-oxobutanoate hydroxymethyltransferase gene gene-HME7025_00284 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00284 HME7025_00285 HME7025_00285 panC panC 333960 334838 - Pantoate--beta-alanine ligase (AMP-forming) ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Pantothenate biosynthesis.%3B Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate%3B Belongs to the pantothenate synthetase family%3B KEGG: scm:SCHCODRAFT_85050 pantoate--beta-alanine ligase gene gene-HME7025_00285 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00285 HME7025_00286 HME7025_00286 HME7025_00286 334908 336098 + Phosphopantothenoylcysteine decarboxylase Decarboxylase%3B Flavoprotein%3B FMN%3B Ligase%3B Lyase%3B Magnesium%3B Metal-binding%3B Multifunctional enzyme.%3B Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine%2C in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity)%3B In the N-terminal sectio%3B belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily%3B In the C-terminal sectio%3B belongs to the PPC synthetase family%3B KEGG: pfq:QQ39_17095 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase gene gene-HME7025_00286 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00286 HME7025_00287 HME7025_00287 HME7025_00287 336150 337427 - putative glucarate transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Uptake of D-glucarate. Belongs to the major facilitator superfamily. Phthalate permease family gene gene-HME7025_00287 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00287 HME7025_00288 HME7025_00288 HME7025_00288 337449 338111 - 2-dehydro-3-deoxy-phosphogluconate aldolase Lyase%3B Schiff base.%3B Belongs to the KHG/KDPG aldolase family%3B KEGG: eao:BD94_0210 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase gene gene-HME7025_00288 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00288 HME7025_00289 HME7025_00289 kdgK kdgK 338114 339124 - 2-dehydro-3-deoxygluconokinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Nucleotide-binding%3B Plasmid%3B Transferase.%3B Involved in the degradation of glucose via the semi- phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2- keto-3-deoxy-6-phosphogluconate (KDPG)%3B Belongs to the carbohydrate kinase pfkB family%3B KEGG: xsa:SB85_12825 2-dehydro-3-deoxygluconokinase gene gene-HME7025_00289 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00289 HME7025_00290 HME7025_00290 uxaC uxaC 339128 340531 - Glucuronate isomerase Isomerase.%3B Belongs to the uronate isomerase family%3B KEGG: sod:Sant_3652 glucuronate isomerase gene gene-HME7025_00290 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00290 HME7025_00291 HME7025_00291 uxaB uxaB 340718 342172 - Tagaturonate reductase NAD%3B Oxidoreductase.%3B Belongs to the mannitol dehydrogenase family. UxaB subfamily%3B KEGG: nso:NIASO_18715 tagaturonate reductase gene gene-HME7025_00291 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00291 HME7025_00292 HME7025_00292 HME7025_00292 342287 342610 - hypothetical protein gene gene-HME7025_00292 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00292 HME7025_00293 HME7025_00293 HME7025_00293 342897 343028 + hypothetical protein gene gene-HME7025_00293 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00293 HME7025_00294 HME7025_00294 HME7025_00294 343028 343297 + hypothetical protein gene gene-HME7025_00294 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00294 HME7025_00295 HME7025_00295 HME7025_00295 343326 343625 + hypothetical protein gene gene-HME7025_00295 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00295 HME7025_00296 HME7025_00296 HME7025_00296 343635 343754 + hypothetical protein gene gene-HME7025_00296 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00296 HME7025_00297 HME7025_00297 rpoC rpoC 344050 348378 - DNA-directed RNA polymerase DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Transcription%3B Transferase.%3B DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta' chain family%3B KEGG: cmr:Cycma_2583 DNA-directed RNA polymerase subunit beta' gene gene-HME7025_00297 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00297 HME7025_00298 HME7025_00298 rpoB rpoB 348440 352360 - DNA-directed RNA polymerase DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Transcription%3B Transferase.%3B DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta chain family%3B KEGG: lby:Lbys_2620 DNA-directed RNA polymerase subunit beta gene gene-HME7025_00298 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00298 HME7025_00299 HME7025_00299 HME7025_00299 352602 353321 + hypothetical protein gene gene-HME7025_00299 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00299 HME7025_00300 HME7025_00300 HME7025_00300 353373 354998 + L-glutamate gamma-semialdehyde dehydrogenase Acetylation%3B Mitochondrion%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Proline metabolism%3B Transit peptide.%3B Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C)%2C derived either from proline or ornithine%2C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde%2C other substrates include succinic%2C glutaric and adipic semialdehydes (By similarity)%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: pko:PKOR_03595 1-pyrroline-5-carboxylate dehydrogenase gene gene-HME7025_00300 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00300 HME7025_00301 HME7025_00301 HME7025_00301 355068 355703 - hypothetical protein gene gene-HME7025_00301 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00301 HME7025_00302 HME7025_00302 HME7025_00302 355847 356023 - hypothetical protein gene gene-HME7025_00302 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00302 HME7025_00303 HME7025_00303 HME7025_00303 356488 357993 + 16S ribosomal RNA rRNA gene-HME7025_00303 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00303 HME7025_00304 HME7025_00304 HME7025_00304 358123 358199 + tRNA-Ile tRNA gene-HME7025_00304 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00304 HME7025_00305 HME7025_00305 HME7025_00305 358267 358343 + tRNA-Ala tRNA gene-HME7025_00305 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00305 HME7025_00306 HME7025_00306 HME7025_00306 358656 361485 + 23S ribosomal RNA rRNA gene-HME7025_00306 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00306 HME7025_00307 HME7025_00307 HME7025_00307 361554 361665 + 5S ribosomal RNA rRNA gene-HME7025_00307 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00307 HME7025_00308 HME7025_00308 HME7025_00308 362117 362668 + hypothetical protein gene gene-HME7025_00308 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00308 HME7025_00309 HME7025_00309 HME7025_00309 362688 363086 + hypothetical protein gene gene-HME7025_00309 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00309 HME7025_00310 HME7025_00310 gatB gatB 363145 364599 + Asparaginyl-tRNA synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)%3B Belongs to the GatB/GatE family. GatB subfamily%3B KEGG: abu:Abu_0030 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B gene gene-HME7025_00310 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00310 HME7025_00311 HME7025_00311 HME7025_00311 364609 365721 + Thiol-disulfide oxidoreductase ResA Cell membrane%3B Cytochrome c-type biogenesis%3B Disulfide bond%3B Membrane%3B Oxidoreductase%3B Redox-active center%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix.%3B Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA%2C leading to breakage of disulfide bonds in apocytochrome%3B following this reduction heme can be covalently attached%3B Belongs to the thioredoxin family. ResA subfamily%3B Contains 1 thioredoxin domain gene gene-HME7025_00311 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00311 HME7025_00312 HME7025_00312 proC proC 365725 366525 + Pyrroline-5-carboxylate reductase Amino-acid biosynthesis%3B NADP%3B Oxidoreductase%3B Proline biosynthesis.%3B Belongs to the pyrroline-5-carboxylate reductase family%3B KEGG: dfe:Dfer_3513 pyrroline-5-carboxylate reductase gene gene-HME7025_00312 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00312 HME7025_00313 HME7025_00313 HME7025_00313 366658 367383 + hypothetical protein gene gene-HME7025_00313 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00313 HME7025_00314 HME7025_00314 HME7025_00314 367388 369241 - DNA mismatch repair protein MutL DNA damage%3B DNA repair.%3B This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker'%2C a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex%3B Belongs to the DNA mismatch repair MutL/HexB family gene gene-HME7025_00314 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00314 HME7025_00315 HME7025_00315 HME7025_00315 369337 369723 - 50S ribosomal protein L7/L12 Ribonucleoprotein%3B Ribosomal protein.%3B Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation%3B Belongs to the ribosomal protein L7/L12P family gene gene-HME7025_00315 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00315 HME7025_00316 HME7025_00316 HME7025_00316 369790 370323 - 50S ribosomal protein L10 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Forms part of the ribosomal stalk%2C playing a central role in the interaction of the ribosome with GTP-bound translation factors%3B Belongs to the ribosomal protein L10P family gene gene-HME7025_00316 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00316 HME7025_00317 HME7025_00317 HME7025_00317 370326 371024 - 50S ribosomal protein L1 Repressor%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Translation regulation%3B tRNA-binding.%3B Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome%2C and is involved in E site tRNA release%3B Protein L1 is also a translational repressor protein%2C it controls the translation of the L11 operon by binding to its mRNA%3B Belongs to the ribosomal protein L1P family gene gene-HME7025_00317 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00317 HME7025_00318 HME7025_00318 HME7025_00318 371063 371500 - 50S ribosomal protein L11 Methylation%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors%3B Belongs to the ribosomal protein L11P family gene gene-HME7025_00318 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00318 HME7025_00319 HME7025_00319 HME7025_00319 371718 372188 - hypothetical protein gene gene-HME7025_00319 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00319 HME7025_00320 HME7025_00320 HME7025_00320 372310 372906 - Transcription termination/antitermination protein NusG Transcription%3B Transcription antitermination%3B Transcription regulation%3B Transcription termination.%3B Participates in transcription elongation%2C termination and antitermination%3B Belongs to the NusG family gene gene-HME7025_00320 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00320 HME7025_00321 HME7025_00321 HME7025_00321 372943 373134 - hypothetical protein gene gene-HME7025_00321 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00321 HME7025_00322 HME7025_00322 HME7025_00322 373171 373244 - tRNA-Trp tRNA gene-HME7025_00322 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00322 HME7025_00323 HME7025_00323 HME7025_00323 373307 374053 - hypothetical protein gene gene-HME7025_00323 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00323 HME7025_00324 HME7025_00324 HME7025_00324 374205 375392 - Elongation factor Tu Cytoplasm%3B Elongation factor%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis.%3B This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene-HME7025_00324 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00324 HME7025_00325 HME7025_00325 HME7025_00325 375474 375548 - tRNA-Thr tRNA gene-HME7025_00325 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00325 HME7025_00326 HME7025_00326 HME7025_00326 375636 375708 - tRNA-Gly tRNA gene-HME7025_00326 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00326 HME7025_00327 HME7025_00327 HME7025_00327 375751 375836 - tRNA-Tyr tRNA gene-HME7025_00327 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00327 HME7025_00328 HME7025_00328 HME7025_00328 375938 377116 - hypothetical protein gene gene-HME7025_00328 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00328 HME7025_00329 HME7025_00329 HME7025_00329 377121 377918 - hypothetical protein gene gene-HME7025_00329 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00329 HME7025_00330 HME7025_00330 HME7025_00330 377915 378463 - ECF RNA polymerase sigma factor SigW DNA-binding%3B Sigma factor%3B Stress response%3B Transcription%3B Transcription regulation.%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RsiW for this protein) until released by regulated membrane proteolysis. Sigma-W controls genes involved in transport processes and detoxification%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene-HME7025_00330 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00330 HME7025_00331 HME7025_00331 murI murI 378569 379378 + Glutamate racemase Cell shape%3B Cell wall biogenesis/degradation%3B Isomerase%3B Peptidoglycan synthesis.%3B Provides the (R)-glutamate required for cell wall biosynthesis%3B Belongs to the aspartate/glutamate racemases family%3B KEGG: pre:PCA10_48230 glutamate racemase gene gene-HME7025_00331 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00331 HME7025_00332 HME7025_00332 HME7025_00332 379380 379667 - hypothetical protein gene gene-HME7025_00332 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00332 HME7025_00333 HME7025_00333 HME7025_00333 379660 380217 - putative membrane protein YozB Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_00333 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00333 HME7025_00334 HME7025_00334 HME7025_00334 380201 380920 - hypothetical protein gene gene-HME7025_00334 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00334 HME7025_00335 HME7025_00335 HME7025_00335 380945 381262 - hypothetical protein gene gene-HME7025_00335 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00335 HME7025_00336 HME7025_00336 coxC coxC 381282 382049 - Cytochrome-c oxidase Cell membrane%3B Membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the cytochrome c oxidase subunit 3 family%3B KEGG: dok:MED134_11511 cytochrome c oxidase subunit III gene gene-HME7025_00336 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00336 HME7025_00337 HME7025_00337 HME7025_00337 382061 382639 - Cytochrome-c oxidase Cell membrane%3B Electron transport%3B Membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer%2C pumping 2 protons/electron (By similarity)%3B Belongs to the cytochrome c oxidase subunit 3 family%3B KEGG: bbd:Belba_3787 cytochrome c oxidase subunit III gene gene-HME7025_00337 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00337 HME7025_00338 HME7025_00338 cyoE cyoE 382641 383492 - Protoheme IX farnesyltransferase Cell membrane%3B Heme biosynthesis%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group%3B Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily%3B KEGG: pis:Pisl_0310 protoheme IX farnesyltransferase%3B Transferring alkyl or aryl groups%2C other than methyl groups gene gene-HME7025_00338 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00338 HME7025_00339 HME7025_00339 HME7025_00339 383494 384399 - hypothetical protein gene gene-HME7025_00339 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00339 HME7025_00340 HME7025_00340 coxA coxA 384471 386375 - Cytochrome-c oxidase Copper%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Mitochondrion inner membrane%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. Belongs to the heme-copper respiratory oxidase family%3B KEGG: rme:Rmet_0262 cytochrome c oxidase subunit I gene gene-HME7025_00340 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00340 HME7025_00341 HME7025_00341 coxB coxB 386405 387490 - Cytochrome-c oxidase Cell membrane%3B Copper%3B Electron transport%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Respiratory chain%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). Belongs to the cytochrome c oxidase subunit 2 family%3B KEGG: fae:FAES_1074 cytochrome c oxidase subunit II gene gene-HME7025_00341 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00341 HME7025_00342 HME7025_00342 HME7025_00342 387523 388884 - hypothetical protein gene gene-HME7025_00342 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00342 HME7025_00343 HME7025_00343 HME7025_00343 388918 389529 - hypothetical protein gene gene-HME7025_00343 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00343 HME7025_00344 HME7025_00344 HME7025_00344 389568 390089 - hypothetical protein gene gene-HME7025_00344 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00344 HME7025_00345 HME7025_00345 HME7025_00345 390118 391515 - hypothetical protein gene gene-HME7025_00345 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00345 HME7025_00346 HME7025_00346 HME7025_00346 391548 394595 - Hdr-like menaquinol oxidoreductase iron-sulfur subunit 4Fe-4S%3B Cell membrane%3B Electron transport%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Signal%3B Transport.%3B Has menaquinol-oxidizing activity. HmeA%2C HmeB and HmeE subunits may together catalyze electron transfer from menaquinol to cytochrome c. Contains 1 4Fe-4S ferredoxin-type domain gene gene-HME7025_00346 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00346 HME7025_00347 HME7025_00347 HME7025_00347 394647 395852 - hypothetical protein gene gene-HME7025_00347 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00347 HME7025_00348 HME7025_00348 HME7025_00348 396065 396138 - tRNA-Cys tRNA gene-HME7025_00348 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00348 HME7025_00349 HME7025_00349 HME7025_00349 396339 397589 - hypothetical protein gene gene-HME7025_00349 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00349 HME7025_00350 HME7025_00350 HME7025_00350 397732 398523 + hypothetical protein gene gene-HME7025_00350 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00350 HME7025_00351 HME7025_00351 hipO hipO 398520 399713 - Hippurate hydrolase Hydrolase.%3B Belongs to the peptidase M20 family%3B KEGG: ngl:RG1141_CH37520 hippurate hydrolase gene gene-HME7025_00351 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00351 HME7025_00352 HME7025_00352 HME7025_00352 399825 400340 + hypothetical protein gene gene-HME7025_00352 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00352 HME7025_00353 HME7025_00353 HME7025_00353 400343 401128 + hypothetical protein gene gene-HME7025_00353 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00353 HME7025_00354 HME7025_00354 HME7025_00354 401121 401606 - hypothetical protein gene gene-HME7025_00354 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00354 HME7025_00355 HME7025_00355 HME7025_00355 401704 402774 + Peptide chain release factor Cytoplasm%3B Methylation%3B Protein biosynthesis.%3B Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene-HME7025_00355 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00355 HME7025_00356 HME7025_00356 phoR phoR 402932 403960 - Histidine kinase ATP-binding%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphate transport%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Two-component regulatory system.%3B Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals. Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: lby:Lbys_1733 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR gene gene-HME7025_00356 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00356 HME7025_00357 HME7025_00357 purB purB 404081 405445 + Adenylosuccinate lyase Lyase%3B Purine biosynthesis.%3B Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily%3B KEGG: pbt:ING2E5B_0989 adenylosuccinate lyase gene gene-HME7025_00357 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00357 HME7025_00358 HME7025_00358 glo1 glo1 405450 405842 + Lactoylglutathione lyase To B. subtilis YwkD%3B KEGG: vfi:VF_A0640 lactoylglutathione lyase gene gene-HME7025_00358 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00358 HME7025_00359 HME7025_00359 trpE trpE 406048 407469 + Anthranilate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Chloroplast%3B Lyase%3B Plastid%3B Transit peptide%3B Tryptophan biosynthesis.%3B Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate%2C an intermediate in the biosynthesis of L-tryptophan. In the first step%2C the glutamine- binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by the large alpha subunit of AS to produce anthranilate (By similarity)%3B Belongs to the anthranilate synthase component I family%3B KEGG: pru:PRU_1455 anthranilate synthase component I gene gene-HME7025_00359 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00359 HME7025_00360 HME7025_00360 pabA pabA 407476 408039 + Aminodeoxychorismate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Glutamine amidotransferase%3B Lyase%3B Tryptophan biosynthesis.%3B Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate%2C an intermediate in the biosynthesis of L-tryptophan. In the first step%2C the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG%2C TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity)%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: dda:Dd703_0367 para-aminobenzoate synthetase component II gene gene-HME7025_00360 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00360 HME7025_00361 HME7025_00361 trpD trpD 408043 409032 + Anthranilate phosphoribosyltransferase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Glycosyltransferase%3B Magnesium%3B Metal-binding%3B Transferase%3B Tryptophan biosynthesis.%3B Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)%3B Belongs to the anthranilate phosphoribosyltransferase family%3B KEGG: nmu:Nmul_A2563 anthranilate phosphoribosyltransferase gene gene-HME7025_00361 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00361 HME7025_00362 HME7025_00362 trpC trpC 409034 409822 + Indole-3-glycerol-phosphate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Decarboxylase%3B Lyase%3B Tryptophan biosynthesis.%3B Belongs to the TrpC family%3B KEGG: dau:Daud_1188 indole-3-glycerol phosphate synthase gene gene-HME7025_00362 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00362 HME7025_00363 HME7025_00363 trpF trpF 409824 410441 + Phosphoribosylanthranilate isomerase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Isomerase%3B Tryptophan biosynthesis.%3B Belongs to the TrpF family%3B KEGG: scn:Solca_1272 phosphoribosylanthranilate isomerase gene gene-HME7025_00363 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00363 HME7025_00364 HME7025_00364 trpB trpB 410446 411636 + Tryptophan synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Lyase%3B Pyridoxal phosphate%3B Tryptophan biosynthesis.%3B The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine%3B Belongs to the TrpB family%3B KEGG: doi:FH5T_04045 tryptophan synthase beta chain gene gene-HME7025_00364 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00364 HME7025_00365 HME7025_00365 trpA trpA 411637 412416 + Tryptophan synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Lyase%3B Tryptophan biosynthesis.%3B The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate%3B Belongs to the TrpA family%3B KEGG: pdi:BDI_0586 tryptophan synthase alpha chain gene gene-HME7025_00365 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00365 HME7025_00366 HME7025_00366 HME7025_00366 412547 412900 + 50S ribosomal protein L19 Ribonucleoprotein%3B Ribosomal protein.%3B This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site%3B Belongs to the ribosomal protein L19P family gene gene-HME7025_00366 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00366 HME7025_00367 HME7025_00367 HME7025_00367 413345 413953 - Non-specific serine/threonine protein kinase KEGG: gba:J421_2130 serine/threonine protein kinase%2C bacterial gene gene-HME7025_00367 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00367 HME7025_00368 HME7025_00368 HME7025_00368 414268 414975 - Macrolide export ATP-binding/permease protein MacB Antibiotic resistance%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain gene gene-HME7025_00368 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00368 HME7025_00369 HME7025_00369 HME7025_00369 415131 416162 + hypothetical protein gene gene-HME7025_00369 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00369 HME7025_00370 HME7025_00370 HME7025_00370 416265 416840 - hypothetical protein gene gene-HME7025_00370 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00370 HME7025_00371 HME7025_00371 HME7025_00371 416947 419040 - Elongation factor Cytoplasm%3B Elongation factor%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis.%3B Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene-HME7025_00371 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00371 HME7025_00372 HME7025_00372 purF purF 419189 419869 + Amidophosphoribosyltransferase KEGG: chu:CHU_3495 amidophosphoribosyltransferase gene gene-HME7025_00372 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00372 HME7025_00373 HME7025_00373 HME7025_00373 419879 421138 - hypothetical protein gene gene-HME7025_00373 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00373 HME7025_00374 HME7025_00374 HME7025_00374 421202 424552 - Transcription-repair-coupling factor ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding.%3B Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA%2C and recruitment of nucleotide excision repair machinery to the damaged site%3B In the N-terminal sectio%3B belongs to the UvrB family%3B In the C-terminal sectio%3B belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: chu:CHU_3453 transcription-repair coupling factor (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene-HME7025_00374 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00374 HME7025_00375 HME7025_00375 HME7025_00375 424777 427260 + hypothetical protein gene gene-HME7025_00375 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00375 HME7025_00376 HME7025_00376 dpm1 dpm1 427323 428063 - Dolichyl-phosphate beta-D-mannosyltransferase KEGG: thg:TCELL_0879 dolichol-phosphate mannosyltransferase gene gene-HME7025_00376 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00376 HME7025_00377 HME7025_00377 HME7025_00377 428119 429162 + Inner membrane protein alx Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the TerC family gene gene-HME7025_00377 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00377 HME7025_00378 HME7025_00378 xynB xynB 429269 430156 - Xylan 1%2C4-beta-xylosidase DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH araC/xylS-type DNA-binding domain%3B KEGG: pih:UB51_19140 xylan 1%2C4-beta-xylosidase gene gene-HME7025_00378 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00378 HME7025_00379 HME7025_00379 HME7025_00379 430284 431075 + hypothetical protein gene gene-HME7025_00379 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00379 HME7025_00380 HME7025_00380 HME7025_00380 431103 431294 - hypothetical protein gene gene-HME7025_00380 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00380 HME7025_00381 HME7025_00381 HME7025_00381 431448 432782 + Secernin-1 Acetylation%3B Cytoplasm%3B Exocytosis.%3B Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium%3B Belongs to the peptidase C69 family. Secernin subfamily gene gene-HME7025_00381 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00381 HME7025_00382 HME7025_00382 aofH aofH 432769 434115 + Monoamine oxidase Acetylation%3B FAD%3B Flavoprotein%3B Membrane%3B Mitochondrion%3B Mitochondrion outer membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity)%3B Belongs to the flavin monoamine oxidase family%3B KEGG: sct:SCAT_p1120 monoamine oxidase gene gene-HME7025_00382 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00382 HME7025_00383 HME7025_00383 HME7025_00383 434142 434975 - Carboxymethylenebutenolidase KEGG: sli:Slin_5500 carboxymethylenebutenolidase gene gene-HME7025_00383 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00383 HME7025_00384 HME7025_00384 HME7025_00384 435065 438436 + Cytochrome c-551 Electron transport%3B Heme%3B Iron%3B Metal-binding%3B Transport. gene gene-HME7025_00384 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00384 HME7025_00385 HME7025_00385 HME7025_00385 438480 438701 - DNA-binding protein DNA-binding.%3B Binds double-stranded DNA (dsDNA) gene gene-HME7025_00385 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00385 HME7025_00386 HME7025_00386 HME7025_00386 438712 440571 - Cytochrome c bioproteinis ATP-binding export protein CcmA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Cytochrome c-type biogenesis%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. CcmA exporter (TC 3. A. 1. 107) family%3B Contains 1 ABC transporter domain gene gene-HME7025_00386 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00386 HME7025_00387 HME7025_00387 HME7025_00387 440593 441459 - Sec-independent protein translocase protein TatC Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes%3B Belongs to the TatC family gene gene-HME7025_00387 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00387 HME7025_00388 HME7025_00388 glyA glyA 441469 442761 - Glycine hydroxymethyltransferase Amino-acid biosynthesis%3B Cytoplasm%3B One-carbon metabolism%3B Pyridoxal phosphate%3B Transferase.%3B Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines%2C thymidylate%2C methionine%2C and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids%2C producing glycine and aldehydes%2C via a retro-aldol mechanism%3B Belongs to the SHMT family%3B KEGG: cat:CA2559_09233 glycine hydroxymethyltransferase gene gene-HME7025_00388 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00388 HME7025_00389 HME7025_00389 dsbD dsbD 442961 444934 + Protein-disulfide reductase KEGG: cmr:Cycma_1721 thiol:disulfide interchange protein DsbD gene gene-HME7025_00389 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00389 HME7025_00390 HME7025_00390 HME7025_00390 444937 445386 + hypothetical protein gene gene-HME7025_00390 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00390 HME7025_00391 HME7025_00391 HME7025_00391 445441 445674 - hypothetical protein gene gene-HME7025_00391 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00391 HME7025_00392 HME7025_00392 HME7025_00392 445748 447475 - hypothetical protein gene gene-HME7025_00392 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00392 HME7025_00393 HME7025_00393 dkgA dkgA 447724 448539 + 2%2C5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) NADP%3B Oxidoreductase.%3B Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis%3B Belongs to the aldo/keto reductase family%3B KEGG: cbv:U729_2157 2%2C5-diketo-D-gluconate reductase A gene gene-HME7025_00393 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00393 HME7025_00394 HME7025_00394 HME7025_00394 448626 449678 - 3-ketosteroid-9-alpha-hydroxylase reductase subunit 2Fe-2S%3B FAD%3B Flavoprotein%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase.%3B Catalyzes the opening of ring B of 1%2C4-androstadiene- 3%2C17%2C-dione (ADD) and 4-androstene-3%2C17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta-cleavage (By similarity)%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 FAD-binding FR-type domain gene gene-HME7025_00394 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00394 HME7025_00395 HME7025_00395 amiA amiA 449689 451194 - N-acetylmuramoyl-L-alanine amidase Signal.%3B Belongs to the UPF0748 family%3B KEGG: asf:SFBM_0237 N-acetylmuramoyl-L-alanine amidase gene gene-HME7025_00395 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00395 HME7025_00396 HME7025_00396 HME7025_00396 451237 451935 - Protein PilG Phosphoprotein%3B Two-component regulatory system.%3B Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. Contains 1 response regulatory domain gene gene-HME7025_00396 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00396 HME7025_00397 HME7025_00397 HME7025_00397 452043 453140 + UPF0118 inner membrane protein YhhT Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0118 (PerM) family gene gene-HME7025_00397 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00397 HME7025_00398 HME7025_00398 HME7025_00398 453126 453869 - Chemotaxis response regulator protein-glutamate methylesterase Chemotaxis%3B Cytoplasm%3B Hydrolase%3B Phosphoprotein.%3B Involved in the modulation of the chemotaxis syste%3B catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR%3B Contains 1 cheB-type methylesterase domain%3B Contains 1 response regulatory domain gene gene-HME7025_00398 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00398 HME7025_00399 HME7025_00399 yesM yesM 453897 454934 - Histidine kinase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system.%3B Member of the two-component regulatory system YehU/YehT%2C which may be involved in the stationary-phase control network. Activates YehT by phosphorylation (By similarity)%3B Contains 1 histidine kinase domain%3B KEGG: bpb:bpr_I1321 two-component system%2C sensor histidine kinase YesM gene gene-HME7025_00399 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00399 HME7025_00400 HME7025_00400 gpmB gpmB 454937 455578 - Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Acetylation%3B Apoptosis%3B Autophagy%3B Cytoplasm%3B Hydrolase%3B Mitochondrion%3B Nucleus.%3B Fructose-bisphosphatase hydrolyzing fructose-2%2C6- bisphosphate as well as fructose-1%2C6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2%2C6-bisphosphate in a p53/TP53- dependent manner%2C resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content%2C correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2- dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity. In response to cardiac damage stress%2C mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death%2C and exacerbates cardiac damage. Plays a role in adult intestinal regeneratio%3B contributes to the growth%2C proliferation and survival of intestinal crypts following tissue ablation. Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions. Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses. Involved in intestinal tumor progression%3B Belongs to the phosphoglycerate mutase family%3B KEGG: law:LACWKB8_1418 probable phosphoglycerate mutase gene gene-HME7025_00400 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00400 HME7025_00401 HME7025_00401 menI menI 455700 456065 + 1%2C4-dihydroxy-2-naphthoyl-CoA hydrolase Cytoplasm%3B Hydrolase.%3B Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules%3B Belongs to the thioesterase PaaI family%3B KEGG: xbv:XBW1_2989 1%2C4-dihydroxy-2-naphthoyl-CoA hydrolase gene gene-HME7025_00401 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00401 HME7025_00402 HME7025_00402 HME7025_00402 456095 457765 + hypothetical protein gene gene-HME7025_00402 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00402 HME7025_00403 HME7025_00403 HME7025_00403 457768 458253 + hypothetical protein gene gene-HME7025_00403 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00403 HME7025_00404 HME7025_00404 HME7025_00404 458317 459312 + uncharacterized protein To bacterial alkanal monooxygenase alpha and beta chains gene gene-HME7025_00404 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00404 HME7025_00405 HME7025_00405 HME7025_00405 459367 459891 + hypothetical protein gene gene-HME7025_00405 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00405 HME7025_00406 HME7025_00406 entC entC 459948 461117 + Isochorismate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Lyase%3B Tryptophan biosynthesis.%3B Belongs to the anthranilate synthase component I family%3B KEGG: dfe:Dfer_5138 isochorismate synthase gene gene-HME7025_00406 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00406 HME7025_00407 HME7025_00407 HME7025_00407 461114 462436 - Hemolysin CBS domain%3B Cytolysis%3B Hemolysis%3B Repeat%3B Toxin.%3B Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. Belongs to the UPF0053 family%3B Contains 2 CBS domains gene gene-HME7025_00407 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00407 HME7025_00408 HME7025_00408 HME7025_00408 462442 462714 - hypothetical protein gene gene-HME7025_00408 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00408 HME7025_00409 HME7025_00409 HME7025_00409 462719 465271 - putative cytochrome c biosynthesis protein Cytochrome c-type biogenesis%3B Mitochondrion%3B RNA editing.%3B Could be involved in assembly and maturation of cytochromes c. May play a role in guidance of apocytochromes and heme groups for the covalent linkage introduced by the cytochrome- c-heme lyase. Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family gene gene-HME7025_00409 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00409 HME7025_00410 HME7025_00410 HME7025_00410 465268 465717 - hypothetical protein gene gene-HME7025_00410 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00410 HME7025_00411 HME7025_00411 HME7025_00411 465722 465931 - hypothetical protein gene gene-HME7025_00411 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00411 HME7025_00412 HME7025_00412 HME7025_00412 465928 466608 - Heme exporter protein Cell inner membrane%3B Cell membrane%3B Cytochrome c-type biogenesis%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. Belongs to the CcmC/CycZ/HelC family gene gene-HME7025_00412 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00412 HME7025_00413 HME7025_00413 HME7025_00413 466596 467261 - hypothetical protein gene gene-HME7025_00413 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00413 HME7025_00414 HME7025_00414 HME7025_00414 467453 467677 + hypothetical protein gene gene-HME7025_00414 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00414 HME7025_00415 HME7025_00415 HME7025_00415 467686 469812 + Ferrous iron transport protein B Cell inner membrane%3B Cell membrane%3B GTP-binding%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Fe(2+) uptake system%2C probably driven by GTP%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. FeoB GTPase (TC 9. A. 8) family%3B Contains 1 FeoB-type G (guanine nucleotide-binding) domain gene gene-HME7025_00415 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00415 HME7025_00416 HME7025_00416 HME7025_00416 469813 470262 - hypothetical protein gene gene-HME7025_00416 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00416 HME7025_00417 HME7025_00417 HME7025_00417 470293 470715 - hypothetical protein gene gene-HME7025_00417 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00417 HME7025_00418 HME7025_00418 comA comA 470871 471632 + Phosphosulfolactate synthase Coenzyme M biosynthesis%3B Lyase.%3B Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL). Belongs to the phosphosulfolactate synthase family%3B KEGG: cpi:Cpin_1670 phosphosulfolactate synthase gene gene-HME7025_00418 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00418 HME7025_00419 HME7025_00419 HME7025_00419 471683 472321 + hypothetical protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the DedA family gene gene-HME7025_00419 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00419 HME7025_00420 HME7025_00420 aroE aroE 472323 473081 + Shikimate dehydrogenase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B NADP%3B Oxidoreductase.%3B Involved in the biosynthesis of the chorismate%2C which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)%3B Belongs to the shikimate dehydrogenase family%3B KEGG: psn:Pedsa_3035 shikimate dehydrogenase gene gene-HME7025_00420 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00420 HME7025_00421 HME7025_00421 pyrR pyrR 473078 473596 - Uracil phosphoribosyltransferase KEGG: phe:Phep_3621 pyrimidine operon attenuation protein / uracil phosphoribosyltransferase gene gene-HME7025_00421 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00421 HME7025_00422 HME7025_00422 HME7025_00422 473678 474223 + hypothetical protein gene gene-HME7025_00422 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00422 HME7025_00423 HME7025_00423 ruvX ruvX 474248 474658 + Putative pre-16S rRNA nuclease Cytoplasm%3B Hydrolase%3B Nuclease%3B Ribosome biogenesis.%3B Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA%3B Belongs to the YqgF nuclease family%3B KEGG: dpb:BABL1_411 putative holliday junction resolvase%3B Acting on ester bonds gene gene-HME7025_00423 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00423 HME7025_00424 HME7025_00424 HME7025_00424 474691 475518 - hypothetical protein gene gene-HME7025_00424 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00424 HME7025_00425 HME7025_00425 HME7025_00425 475751 476596 + hypothetical protein gene gene-HME7025_00425 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00425 HME7025_00426 HME7025_00426 HME7025_00426 476634 477380 + hypothetical protein gene gene-HME7025_00426 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00426 HME7025_00427 HME7025_00427 HME7025_00427 477424 478845 + hypothetical protein gene gene-HME7025_00427 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00427 HME7025_00428 HME7025_00428 aroC aroC 478852 479937 + Chorismate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B FAD%3B Flavoprotein%3B FMN%3B Lyase%3B NADP.%3B Catalyzes the anti-1%2C4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate%2C which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system%3B Belongs to the chorismate synthase family%3B KEGG: can:Cyan10605_2524 chorismate synthase gene gene-HME7025_00428 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00428 HME7025_00429 HME7025_00429 tadA tadA 479937 480377 + tRNA(adenine(34)) deaminase Hydrolase%3B Metal-binding%3B tRNA processing%3B Zinc.%3B Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)%3B Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: vch:VC0864 tRNA(adenine34) deaminase gene gene-HME7025_00429 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00429 HME7025_00430 HME7025_00430 sod2 sod2 480472 481083 + Superoxide dismutase Iron%3B Metal-binding%3B Oxidoreductase.%3B Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family%3B KEGG: fau:Fraau_2234 superoxide dismutase%2C Fe-Mn family gene gene-HME7025_00430 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00430 HME7025_00431 HME7025_00431 HME7025_00431 481177 481252 + tRNA-His tRNA gene-HME7025_00431 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00431 HME7025_00432 HME7025_00432 HME7025_00432 481398 482753 - hypothetical protein gene gene-HME7025_00432 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00432 HME7025_00433 HME7025_00433 HME7025_00433 482922 483542 + hypothetical protein gene gene-HME7025_00433 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00433 HME7025_00434 HME7025_00434 HME7025_00434 483567 484199 + hypothetical protein gene gene-HME7025_00434 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00434 HME7025_00435 HME7025_00435 HME7025_00435 484261 485145 + hypothetical protein gene gene-HME7025_00435 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00435 HME7025_00436 HME7025_00436 HME7025_00436 485138 486202 - Mannose-1-phosphate guanylyltransferase Alginate biosynthesis%3B Cobalt%3B GTP-binding%3B Isomerase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics%3B Belongs to the mannose-6-phosphate isomerase type 2 family%3B KEGG: pgi:PG2215 mannose-1-phosphate guanylyltransferase gene gene-HME7025_00436 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00436 HME7025_00437 HME7025_00437 HME7025_00437 486541 489408 + hypothetical protein gene gene-HME7025_00437 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00437 HME7025_00438 HME7025_00438 HME7025_00438 489488 492325 + UvrABC system protein ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA excision%3B DNA repair%3B DNA-binding%3B Excision nuclease%3B Metal-binding%3B Nucleotide-binding%3B Repeat%3B SOS response%3B Zinc%3B Zinc-finger.%3B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Belongs to the ABC transporter superfamily. UvrA family%3B Contains 2 ABC transporter domains gene gene-HME7025_00438 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00438 HME7025_00439 HME7025_00439 HME7025_00439 492390 493010 - hypothetical protein gene gene-HME7025_00439 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00439 HME7025_00440 HME7025_00440 HME7025_00440 493168 494535 + uncharacterized protein Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix.%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: gfo:GFO_1637 null%3B Oxidoreductases gene gene-HME7025_00440 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00440 HME7025_00441 HME7025_00441 vanY vanY 494540 495535 + Serine-type D-Ala-D-Ala carboxypeptidase KEGG: xfl:P303_10370 D-alanyl-D-alanine carboxypeptidase gene gene-HME7025_00441 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00441 HME7025_00442 HME7025_00442 HME7025_00442 495539 496438 + Alkylglycerol monooxygenase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Oxidoreductase%3B Steroid biosynthesis%3B Steroid metabolism%3B Sterol biosynthesis%3B Sterol metabolism%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the sterol desaturase family%3B KEGG: tca:657448 alkylglycerol monooxygenase gene gene-HME7025_00442 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00442 HME7025_00443 HME7025_00443 HME7025_00443 496416 497198 + uncharacterized protein Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix.%3B Contains 2 4Fe-4S ferredoxin-type domains gene gene-HME7025_00443 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00443 HME7025_00444 HME7025_00444 HME7025_00444 497203 497697 + hypothetical protein gene gene-HME7025_00444 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00444 HME7025_00445 HME7025_00445 HME7025_00445 497701 498195 + GAF domain-containing protein Belongs to the free Met sulfoxide reductase family%3B Contains 1 GAF domain gene gene-HME7025_00445 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00445 HME7025_00446 HME7025_00446 HME7025_00446 498201 498704 - uncharacterized protein Metal-binding.%3B Belongs to the DinB family gene gene-HME7025_00446 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00446 HME7025_00447 HME7025_00447 pisD pisD 498780 499442 - Phosphatidylserine decarboxylase Decarboxylase%3B Lipid biosynthesis%3B Lipid metabolism%3B Lyase%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Pyruvate%3B Zymogen.%3B Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily%3B KEGG: cmr:Cycma_1425 phosphatidylserine decarboxylase gene gene-HME7025_00447 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00447 HME7025_00448 HME7025_00448 HME7025_00448 499603 501021 + hypothetical protein gene gene-HME7025_00448 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00448 HME7025_00449 HME7025_00449 dpp4 dpp4 501016 503202 - Dipeptidyl-peptidase IV Angiogenesis%3B Apoptosis%3B Cell adhesion%3B Cell junction%3B Cell membrane%3B Cell projection%3B Cleavage on pair of basic residues%3B Coiled coil%3B Disulfide bond%3B Glycoprotein%3B Hydrolase%3B Membrane%3B Protease%3B Secreted%3B Serine protease%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix.%3B Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling%2C fibrosis%2C wound healing%2C inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity%2C with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences%2C on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin%2C heat-denatured type I collagen%2C but not native collagen type I and IV%2C vibronectin%2C tenascin%2C laminin%2C fibronectin%2C fibrin or casein. Have also dipeptidyl peptidase activity%2C exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline%2C with a preference for Ala-Pro%2C Ile-Pro%2C Gly-Pro%2C Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY)%2C peptide YY (PYY)%2C substance P (TAC1) and brain natriuretic peptide 32 (NPPB). The plasma membrane form%2C in association with either DPP4%2C PLAUR or integrins%2C is involved in the pericellular proteolysis of the extracellular matrix (ECM)%2C and hence promotes cell adhesion%2C migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis%2C collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner%3B Belongs to the peptidase S9B family%3B KEGG: hhy:Halhy_3444 dipeptidyl-peptidase 4 gene gene-HME7025_00449 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00449 HME7025_00450 HME7025_00450 HME7025_00450 503211 503765 - hypothetical protein gene gene-HME7025_00450 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00450 HME7025_00451 HME7025_00451 HME7025_00451 503839 504918 + hypothetical protein gene gene-HME7025_00451 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00451 HME7025_00452 HME7025_00452 moaE moaE 504879 505298 - Molybdopterin synthase Cytoplasm%3B Molybdenum cofactor biosynthesis%3B Transferase.%3B Catalytic subunit of the molybdopterin synthase complex%2C a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group%3B Belongs to the MoaE family. MOCS2B subfamily%3B KEGG: prw:PsycPRwf_0222 molybdopterin synthase catalytic subunit gene gene-HME7025_00452 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00452 HME7025_00453 HME7025_00453 folA folA 505300 505791 - Dihydrofolate reductase Antibiotic resistance%3B Methotrexate resistance%3B NADP%3B One-carbon metabolism%3B Oxidoreductase%3B Plasmid%3B Trimethoprim resistance.%3B Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis%2C and for DNA precursor synthesis (By similarity)%3B Belongs to the dihydrofolate reductase family%3B Contains 1 DHFR (dihydrofolate reductase) domain%3B KEGG: kpn:KPN_pKPN5p08198 dihydrofolate reductase gene gene-HME7025_00453 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00453 HME7025_00454 HME7025_00454 carB carB 506000 508828 + Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Amino-acid biosynthesis%3B Arginine biosynthesis%3B ATP-binding%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide-binding%3B Pyrimidine biosynthesis%3B Repeat.%3B Belongs to the CarB family%3B Contains 2 ATP-grasp domains%3B KEGG: clb:Clo1100_3683 carbamoyl-phosphate synthase large subunit gene gene-HME7025_00454 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00454 HME7025_00455 HME7025_00455 HME7025_00455 508847 509095 + hypothetical protein gene gene-HME7025_00455 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00455 HME7025_00456 HME7025_00456 HME7025_00456 509184 509504 + hypothetical protein gene gene-HME7025_00456 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00456 HME7025_00457 HME7025_00457 HME7025_00457 509598 509864 + hypothetical protein gene gene-HME7025_00457 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00457 HME7025_00458 HME7025_00458 HME7025_00458 509871 510992 + Efflux pump periplasmic linker BepF Coiled coil%3B Periplasm%3B Transport.%3B May contribute to resistance to some drugs%2C such as deoxycholate%2C sodium dodecyl sulfate and nalidixic acid%2C in the absence of BepD and BepE%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene-HME7025_00458 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00458 HME7025_00459 HME7025_00459 HME7025_00459 511002 514121 + putative transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Could be a drug efflux pump%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene-HME7025_00459 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00459 HME7025_00460 HME7025_00460 HME7025_00460 514156 515547 + putative efflux pump outer membrane protein SepC Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Probable outer membrane component of the SepABC efflux pump with unknown specificity. Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene-HME7025_00460 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00460 HME7025_00461 HME7025_00461 purN purN 515548 516117 - Phosphoribosylglycinamide formyltransferase Chloroplast%3B Plastid%3B Purine biosynthesis%3B Transferase%3B Transit peptide.%3B Belongs to the GART family%3B KEGG: fbc:FB2170_06555 phosphoribosylglycinamide formyltransferase 1 gene gene-HME7025_00461 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00461 HME7025_00462 HME7025_00462 HME7025_00462 516210 517373 + N-acetyl-alpha-D-glucosaminyl L-malate synthase Glycosyltransferase%3B Nucleotide-binding%3B Transferase.%3B Involved in bacillithiol (BSH) biosynthesis. Catalyzes the first step of the pathway%2C the formation of N- acetylglucosaminylmalate (GlcNAc-Mal) from UDP-N-acetylglucosamine (UDP-GlcNAc) and L-malate%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: saa:SAUSA300_1349 null%3B Hexosyltransferases gene gene-HME7025_00462 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00462 HME7025_00463 HME7025_00463 HME7025_00463 517448 518092 + Fatty acid 2-hydroxylase Endoplasmic reticulum%3B Membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix.%3B Fatty acid 2-hydroxylase involved in the alpha- hydroxylation of sphingolipid-associated very long-chain fatty acids (VLCFA). Probably involved in the resistance response to oxidative stress%3B Belongs to the sterol desaturase family%3B KEGG: gfo:GFO_0302 null%3B Oxidoreductases gene gene-HME7025_00463 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00463 HME7025_00464 HME7025_00464 folK folK 518087 518587 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase ATP-binding%3B Folate biosynthesis%3B Kinase%3B Lyase%3B Magnesium%3B Metal-binding%3B Multifunctional enzyme%3B Nucleotide-binding%3B Transferase.%3B Catalyzes three sequential steps of tetrahydrofolate biosynthesis%3B In the N-terminal sectio%3B belongs to the DHNA family%3B In the central sectio%3B belongs to the HPPK family%3B In the C-terminal sectio%3B belongs to the DHPS family%3B Contains 1 pterin-binding domain%3B KEGG: pmic:NW74_05960 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase gene gene-HME7025_00464 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00464 HME7025_00465 HME7025_00465 HME7025_00465 518616 519185 + UPF0301 protein Belongs to the UPF0301 (AlgH) family gene gene-HME7025_00465 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00465 HME7025_00466 HME7025_00466 recG recG 519194 521287 - DNA helicase ATP-binding%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding.%3B Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) (By similarity)%3B Belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: pom:MED152_03355 ATP-dependent DNA helicase RecG gene gene-HME7025_00466 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00466 HME7025_00467 HME7025_00467 HME7025_00467 521357 522091 + hypothetical protein gene gene-HME7025_00467 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00467 HME7025_00468 HME7025_00468 nuoB nuoB 522095 522607 + NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport%3B Ubiquinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I 20 kDa subunit family%3B KEGG: kge:TQ33_2070 NADH-quinone oxidoreductase subunit B gene gene-HME7025_00468 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00468 HME7025_00469 HME7025_00469 nuoC nuoC 522618 523109 + NADH:ubiquinone reductase (H(+)-translocating) Chloroplast%3B Membrane%3B NAD%3B NADP%3B Oxidoreductase%3B Plastid%3B Plastoquinone%3B Quinone%3B RNA editing%3B Thylakoid%3B Transport.%3B NDH shuttles electrons from NAD(P)H:plastoquinone%2C via FMN and iron-sulfur (Fe-S) centers%2C to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 30 kDa subunit family%3B KEGG: fae:FAES_0025 NADH-quinone oxidoreductase subunit C gene gene-HME7025_00469 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00469 HME7025_00470 HME7025_00470 HME7025_00470 523114 523989 + hypothetical protein gene gene-HME7025_00470 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00470 HME7025_00471 HME7025_00471 HME7025_00471 523989 524882 + hypothetical protein gene gene-HME7025_00471 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00471 HME7025_00472 HME7025_00472 pgaC pgaC 524879 525769 - putative glycosyltransferase Glycosyltransferase%3B Transferase.%3B Belongs to the glycosyltransferase 2 family%3B KEGG: eec:EcWSU1_03780 biofilm PGA synthesis N-glycosyltransferase PgaC%3B Glycosyltransferases gene gene-HME7025_00472 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00472 HME7025_00473 HME7025_00473 msbA msbA 525893 527722 + Lipid A export ATP-binding/permease protein MsbA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Lipid transport%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily. Lipid exporter (TC 3. A. 1. 106) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B KEGG: shg:Sph21_1607 ATP-binding cassette%2C subfamily B%2C bacterial MsbA%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene-HME7025_00473 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00473 HME7025_00474 HME7025_00474 aspB aspB 527833 529035 + Aspartate transaminase Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase.%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: amim:MIM_c08450 aspartate aminotransferase gene gene-HME7025_00474 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00474 HME7025_00475 HME7025_00475 HME7025_00475 529125 530258 - Na(+)/H(+) antiporter NhaA Antiport%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Sodium%3B Sodium transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons%3B Belongs to the NhaA Na(+)/H(+) (TC 2. A. 33) antiporter family gene gene-HME7025_00475 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00475 HME7025_00476 HME7025_00476 HME7025_00476 530277 530984 - Lipid A 1-phosphatase Hydrolase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Lipopolysaccharide biosynthesis%3B Periplasm%3B Signal%3B Virulence.%3B Removes the 1-phosphate group from lipid A species. Absence of phosphate groups in lipid A renders the bacteria resistant to host-derived cationic antimicrobial peptides (CAMP) and allowing it to camouflage itself from the host innate immune response gene gene-HME7025_00476 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00476 HME7025_00477 HME7025_00477 HME7025_00477 530984 532219 - hypothetical protein gene gene-HME7025_00477 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00477 HME7025_00478 HME7025_00478 mraW mraW 532344 533258 + 16S rRNA (cytosine(1402)-N(4))-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase.%3B Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmH family%3B KEGG: asu:Asuc_1940 16S rRNA (cytosine1402-N4)-methyltransferase gene gene-HME7025_00478 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00478 HME7025_00479 HME7025_00479 HME7025_00479 533260 533649 + hypothetical protein gene gene-HME7025_00479 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00479 HME7025_00480 HME7025_00480 HME7025_00480 533653 535782 + Stage V sporulation protein D Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Peptidoglycan synthesis%3B Sporulation.%3B Penicillin-binding protein with an unknown catalytic activity. May have a specialized role in the morphogenesis of spore cortex%2C which is a modified form of peptidoglycan. Pore cortex formation is determined primarily by the mother cell. Belongs to the transpeptidase family%3B Contains 1 PASTA domain gene gene-HME7025_00480 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00480 HME7025_00481 HME7025_00481 murE murE 535784 537244 + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Magnesium%3B Nucleotide-binding%3B Peptidoglycan synthesis.%3B Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan%3B Belongs to the MurCDEF family. MurE subfamily%3B KEGG: che:CAHE_0351 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase gene gene-HME7025_00481 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00481 HME7025_00482 HME7025_00482 mraY mraY 537308 538519 + Phospho-N-acetylmuramoyl-pentapeptide-transferase Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Peptidoglycan synthesis%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan%3B Belongs to the glycosyltransferase 4 family. MraY subfamily%3B KEGG: bvs:BARVI_06725 phospho-N-acetylmuramoyl-pentapeptide-transferase gene gene-HME7025_00482 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00482 HME7025_00483 HME7025_00483 aroA aroA 538533 539774 + 3-phosphoshikimate 1-carboxyvinyltransferase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Cytoplasm%3B Transferase.%3B Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate%3B Belongs to the EPSP synthase family%3B KEGG: aps:CFPG_751 3-phosphoshikimate 1-carboxyvinyltransferase gene gene-HME7025_00483 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00483 HME7025_00484 HME7025_00484 HME7025_00484 539895 541166 + Enamidase To S. coelicolor SCO1861%3B KEGG: bsb:Bresu_0327 enamidase gene gene-HME7025_00484 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00484 HME7025_00485 HME7025_00485 HME7025_00485 541207 541791 - hypothetical protein gene gene-HME7025_00485 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00485 HME7025_00486 HME7025_00486 purK purK 541876 543018 + 5-(carboxyamino)imidazole ribonucleotide synthase ATP-binding%3B Chloroplast%3B Decarboxylase%3B Lyase%3B Nucleotide-binding%3B Plastid%3B Purine biosynthesis%3B Transit peptide.%3B In the C-terminal sectio%3B belongs to the AIR carboxylase family. Class I subfamily%3B Contains 1 ATP-grasp domain%3B KEGG: tig:THII_1039 5-(carboxyamino)imidazole ribonucleotide synthase gene gene-HME7025_00486 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00486 HME7025_00487 HME7025_00487 purE purE 543031 543519 + 5-(carboxyamino)imidazole ribonucleotide mutase ATP-binding%3B Decarboxylase%3B Lyase%3B Nucleotide-binding%3B Purine biosynthesis.%3B In the C-terminal sectio%3B belongs to the AIR carboxylase family. Class I subfamily%3B Contains 1 ATP-grasp domain%3B KEGG: xfa:XF2672 5-(carboxyamino)imidazole ribonucleotide mutase gene gene-HME7025_00487 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00487 HME7025_00488 HME7025_00488 HME7025_00488 543523 544176 + hypothetical protein gene gene-HME7025_00488 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00488 HME7025_00489 HME7025_00489 HME7025_00489 544187 545185 + hypothetical protein gene gene-HME7025_00489 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00489 HME7025_00490 HME7025_00490 HME7025_00490 545175 546092 - Methionyl-tRNA formyltransferase Protein biosynthesis%3B Transferase.%3B Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP%3B Belongs to the Fmt family%3B KEGG: eco:b3288 methionyl-tRNA formyltransferase gene gene-HME7025_00490 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00490 HME7025_00491 HME7025_00491 HME7025_00491 546305 546778 + Transcription elongation factor GreA Coiled coil%3B DNA-binding%3B Transcription%3B Transcription regulation.%3B Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides%3B Belongs to the GreA/GreB family gene gene-HME7025_00491 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00491 HME7025_00492 HME7025_00492 HME7025_00492 546843 548876 + hypothetical protein gene gene-HME7025_00492 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00492 HME7025_00493 HME7025_00493 HME7025_00493 548850 549527 - UPF0001 protein Acetylation%3B Pyridoxal phosphate.%3B Belongs to the UPF0001 family gene gene-HME7025_00493 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00493 HME7025_00494 HME7025_00494 HME7025_00494 549603 550616 + hypothetical protein gene gene-HME7025_00494 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00494 HME7025_00495 HME7025_00495 HME7025_00495 550704 551066 + 30S ribosomal protein S6 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds together with S18 to 16S ribosomal RNA%3B Belongs to the ribosomal protein S6P family gene gene-HME7025_00495 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00495 HME7025_00496 HME7025_00496 HME7025_00496 551068 551319 + 30S ribosomal protein S18 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%2C where it helps stabilize the platform of the 30S subunit%3B Belongs to the ribosomal protein S18P family gene gene-HME7025_00496 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00496 HME7025_00497 HME7025_00497 HME7025_00497 551358 551801 + 50S ribosomal protein L9 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds to the 23S rRNA%3B Belongs to the ribosomal protein L9P family gene gene-HME7025_00497 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00497 HME7025_00498 HME7025_00498 idh1 idh1 551955 553187 - Isocitrate dehydrogenase (NADP(+)) Cytoplasm%3B Glyoxylate bypass%3B Magnesium%3B Manganese%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Tricarboxylic acid cycle.%3B May function in the production of NADPH for fatty acid and sterol synthesis. Belongs to the isocitrate and isopropylmalate dehydrogenases family%3B KEGG: bba:Bd3723 isocitrate dehydrogenase gene gene-HME7025_00498 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00498 HME7025_00499 HME7025_00499 purU purU 553324 554157 + Formyltetrahydrofolate deformylase Hydrolase%3B One-carbon metabolism%3B Purine biosynthesis.%3B Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)%3B Belongs to the PurU family%3B Contains 1 ACT domain%3B KEGG: nis:NIS_0729 formyltetrahydrofolate deformylase gene gene-HME7025_00499 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00499 HME7025_00500 HME7025_00500 HME7025_00500 554212 555546 + Signal recognition particle protein Cytoplasm%3B GTP-binding%3B Nucleotide-binding%3B Ribonucleoprotein%3B RNA-binding%3B Signal recognition particle.%3B Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane%2C the hydrolysis of GTP by both Ffh and FtsY%2C and the dissociation of the SRP-FtsY complex into the individual components%3B Belongs to the GTP-binding SRP family. SRP54 subfamily gene gene-HME7025_00500 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00500 HME7025_00501 HME7025_00501 HME7025_00501 555600 556046 - hypothetical protein gene gene-HME7025_00501 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00501 HME7025_00502 HME7025_00502 pheT pheT 556182 558617 - Phenylalanine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B RNA-binding%3B tRNA-binding.%3B Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily%3B Contains 1 B5 domain%3B Contains 1 FDX-ACB domain%3B Contains 1 tRNA-binding domain%3B KEGG: fte:Fluta_3296 phenylalanyl-tRNA synthetase beta chain gene gene-HME7025_00502 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00502 HME7025_00503 HME7025_00503 HME7025_00503 558624 559196 - Peptide deformylase Hydrolase%3B Iron%3B Metal-binding%3B Protein biosynthesis.%3B Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions%3B Belongs to the polypeptide deformylase family%3B KEGG: cvt:B843_11380 peptide deformylase gene gene-HME7025_00503 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00503 HME7025_00504 HME7025_00504 HME7025_00504 559353 559970 + Inorganic diphosphatase Cytoplasm%3B Hydrolase%3B Magnesium%3B Metal-binding.%3B Catalyzes the irreversible hydrolysis of pyrophosphate (PPi) to phosphate. The MgPPi(2-) complex binds to the enzyme only after a free Mg(2+) ion has bound (Ref. 9). No activity with glycerol-3-phosphate%2C glucose-6-phosphate%2C p-nitrophenylphosphate%2C ADP%2C NADP(+)%2C NAD(+)%2CNADH%2C NADPH or phosphoribosyl pyrophosphate as substrates (Ref. 9). Controls the equilibrium of gluconeogenic reactions in the heterotrophic growth phase of early seedling establishment. Determinates the rate of cytosolic glycolysis%2C providing carbon for seed storage lipid accumulation (PubMed:22566496)%3B Belongs to the PPase family%3B KEGG: sur:STAUR_6239 inorganic pyrophosphatase gene gene-HME7025_00504 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00504 HME7025_00505 HME7025_00505 sppA sppA 560065 561840 + Protease Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Protease%3B Serine protease%3B Transmembrane%3B Transmembrane helix.%3B Digests cleaved signal peptides in vitro%2C its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane (By similarity)%3B Belongs to the peptidase S49 family%3B KEGG: sli:Slin_2408 protease IV%3B Serine endopeptidases gene gene-HME7025_00505 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00505 HME7025_00506 HME7025_00506 bioB bioB 561890 562909 + Biotin synthase 2Fe-2S%3B 4Fe-4S%3B Biotin biosynthesis%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism%3B Belongs to the radical SAM superfamily. Biotin synthase family%3B KEGG: fps:FP0234 biotin synthase gene gene-HME7025_00506 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00506 HME7025_00507 HME7025_00507 HME7025_00507 562958 563359 - hypothetical protein gene gene-HME7025_00507 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00507 HME7025_00508 HME7025_00508 HME7025_00508 563523 563951 - Putative acetyltransferase Acyltransferase%3B Transferase.%3B Could catalyze the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product%3B Belongs to the UPF0039 (ElaA) family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vfi:VF_0102 null%3B Transferring groups other than amino-acyl groups gene gene-HME7025_00508 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00508 HME7025_00509 HME7025_00509 HME7025_00509 564089 565666 - Ribonuclease Cell membrane%3B Endonuclease%3B Hydrolase%3B Membrane%3B Nuclease%3B RNA-binding%3B Transmembrane%3B Transmembrane helix.%3B Endoribonuclease that initiates mRNA decay%3B Belongs to the RNase Y family%3B Contains 1 HD domain%3B Contains 1 KH domain%3B KEGG: efa:EF3170 ribonucrease Y%3B Acting on ester bonds gene gene-HME7025_00509 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00509 HME7025_00510 HME7025_00510 HME7025_00510 565728 566018 - hypothetical protein gene gene-HME7025_00510 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00510 HME7025_00511 HME7025_00511 HME7025_00511 566015 566344 - hypothetical protein gene gene-HME7025_00511 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00511 HME7025_00512 HME7025_00512 HME7025_00512 566358 567860 - hypothetical protein gene gene-HME7025_00512 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00512 HME7025_00513 HME7025_00513 HME7025_00513 567950 568717 - putative response regulatory protein DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system.%3B Contains 1 HTH LytTR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene-HME7025_00513 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00513 HME7025_00514 HME7025_00514 HME7025_00514 568720 569778 - Histidine kinase ATP-binding%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system.%3B Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism%3B Contains 1 histidine kinase domain%3B KEGG: pms:KNP414_04351 two-component system%2C sensor histidine kinase YesM gene gene-HME7025_00514 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00514 HME7025_00515 HME7025_00515 HME7025_00515 569934 571736 + hypothetical protein gene gene-HME7025_00515 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00515 HME7025_00516 HME7025_00516 HME7025_00516 571750 573615 + hypothetical protein gene gene-HME7025_00516 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00516 HME7025_00517 HME7025_00517 HME7025_00517 573679 574056 - hypothetical protein gene gene-HME7025_00517 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00517 HME7025_00518 HME7025_00518 tktA tktA 574221 576641 + Transketolase Oxidoreductase%3B Thiamine pyrophosphate.%3B KEGG: chu:CHU_1992 transketolase gene gene-HME7025_00518 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00518 HME7025_00519 HME7025_00519 nuoI nuoI 576644 577735 + NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Chloroplast%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B NADP%3B Oxidoreductase%3B Plastid%3B Plastoquinone%3B Quinone%3B Repeat%3B Thylakoid.%3B NDH shuttles electrons from NAD(P)H:plastoquinone%2C via FMN and iron-sulfur (Fe-S) centers%2C to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 23 kDa subunit family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: cts:Ctha_2560 NADH-quinone oxidoreductase subunit I gene gene-HME7025_00519 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00519 HME7025_00520 HME7025_00520 ndhG ndhG 577732 578253 + NADH:ubiquinone reductase (H(+)-translocating) Cell membrane%3B Electron transport%3B Membrane%3B Methanogenesis%3B Methanol utilization%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2)%2C via FAD and iron-sulfur (Fe-S) centers%2C to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred%2C two hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient. It also catalyzes the oxidation of F(420)H(2) with quinones such as 2%2C3- dimethyl-1%2C4-naphthoquinone%2C 2-methyl-1%2C4-naphthoquinone and tetramethyl-p-benzoquinone%3B Belongs to the complex I subunit 6 family%3B KEGG: cyj:Cyan7822_2522 NAD(P)H-quinone oxidoreductase subunit 6 gene gene-HME7025_00520 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00520 HME7025_00521 HME7025_00521 nuoK nuoK 578246 578551 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 4L family%3B KEGG: sli:Slin_5943 NADH-quinone oxidoreductase subunit K gene gene-HME7025_00521 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00521 HME7025_00522 HME7025_00522 HME7025_00522 578548 580356 - UvrABC system protein Cytoplasm%3B DNA damage%3B DNA excision%3B DNA repair%3B Excision nuclease%3B SOS response.%3B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision%3B Belongs to the UvrC family%3B Contains 1 GIY-YIG domain%3B Contains 1 UVR domain gene gene-HME7025_00522 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00522 HME7025_00523 HME7025_00523 HME7025_00523 580880 584119 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_00523 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00523 HME7025_00524 HME7025_00524 HME7025_00524 584150 585907 + hypothetical protein gene gene-HME7025_00524 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00524 HME7025_00525 HME7025_00525 HME7025_00525 585983 589474 + hypothetical protein gene gene-HME7025_00525 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00525 HME7025_00526 HME7025_00526 HME7025_00526 589463 590953 - hypothetical protein gene gene-HME7025_00526 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00526 HME7025_00527 HME7025_00527 mrcA mrcA 590943 593255 - Penicillin-binding protein 1A Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Glycosyltransferase%3B Hydrolase%3B Membrane%3B Multifunctional enzyme%3B Peptidoglycan synthesis%3B Signal-anchor%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity)%3B In the N-terminal sectio%3B belongs to the glycosyltransferase 51 family%3B In the C-terminal sectio%3B belongs to the transpeptidase family%3B KEGG: vch:VC2635 penicillin-binding protein 1A%3B Hexosyltransferases gene gene-HME7025_00527 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00527 HME7025_00528 HME7025_00528 HME7025_00528 593257 595371 - hypothetical protein gene gene-HME7025_00528 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00528 HME7025_00529 HME7025_00529 HME7025_00529 595463 595648 + hypothetical protein gene gene-HME7025_00529 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00529 HME7025_00530 HME7025_00530 HME7025_00530 595725 597593 + Penicillin-binding protein Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Multifunctional enzyme%3B Peptidoglycan synthesis%3B Transmembrane%3B Transmembrane helix.%3B Cell wall formatio%3B PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates (By similarity)%3B Belongs to the transpeptidase family gene gene-HME7025_00530 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00530 HME7025_00531 HME7025_00531 HME7025_00531 597590 598879 + Rod shape-determining protein RodA Cell inner membrane%3B Cell membrane%3B Cell shape%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Required for the maintenance of the rod cell shape. Required for the expression of the enzymatic activity of the penicillin-binding protein 2 (PBP2) (By similarity)%3B Belongs to the SEDS family. RodA subfamily gene gene-HME7025_00531 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00531 HME7025_00532 HME7025_00532 HME7025_00532 598892 600127 + 3-(3-hydroxy-phenyl)propionate transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate%2C 3-hydroxybenzoate or gentisate%3B Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2. A. 1. 15) family gene gene-HME7025_00532 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00532 HME7025_00533 HME7025_00533 HME7025_00533 600127 601149 + hypothetical protein gene gene-HME7025_00533 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00533 HME7025_00534 HME7025_00534 HME7025_00534 601146 601520 - UPF0382 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0382 family gene gene-HME7025_00534 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00534 HME7025_00535 HME7025_00535 HME7025_00535 601563 602099 - ATP synthase subunit delta ATP synthesis%3B Cell membrane%3B CF(1)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transport.%3B F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction%3B Belongs to the ATPase delta chain family gene gene-HME7025_00535 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00535 HME7025_00536 HME7025_00536 HME7025_00536 602125 602619 - ATP synthase subunit ATP synthesis%3B Cell membrane%3B CF(0)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Component of the F(0) channel%2C it forms part of the peripheral stalk%2C linking F(1) to F(0)%3B Belongs to the ATPase B chain family gene gene-HME7025_00536 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00536 HME7025_00537 HME7025_00537 HME7025_00537 602746 602991 - ATP synthase subunit ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(0)%3B Hydrogen ion transport%3B Ion transport%3B Lipid-binding%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Key component of the F(0) channe%3B it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits%3B Belongs to the ATPase C chain family gene gene-HME7025_00537 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00537 HME7025_00538 HME7025_00538 HME7025_00538 603030 604091 - ATP synthase subunit ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(0)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Key component of the proton channe%3B it plays a direct role in the translocation of protons across the membrane%3B Belongs to the ATPase A chain family gene gene-HME7025_00538 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00538 HME7025_00539 HME7025_00539 HME7025_00539 604194 604592 - hypothetical protein gene gene-HME7025_00539 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00539 HME7025_00540 HME7025_00540 metX metX 604979 606073 + Homoserine O-acetyltransferase Acyltransferase%3B Amino-acid biosynthesis%3B Cytoplasm%3B Methionine biosynthesis%3B Transferase.%3B Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine%3B Belongs to the AB hydrolase superfamily. HTA family%3B KEGG: dfe:Dfer_2669 homoserine O-acetyltransferase gene gene-HME7025_00540 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00540 HME7025_00541 HME7025_00541 HME7025_00541 606076 606873 + Estradiol 17-beta-dehydrogenase Lipid biosynthesis%3B Lipid metabolism%3B NADP%3B Oxidoreductase%3B Secreted%3B Signal%3B Steroid biosynthesis.%3B Can convert androstan-3-alpha%2C17-beta-diol (3-alpha- diol) to androsterone in vitro%2C suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone)%2C or A-dione (4-androste-3%2C17-dione)%2C and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily%3B KEGG: gth:Geoth_2909 null%3B Oxidoreductases gene gene-HME7025_00541 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00541 HME7025_00542 HME7025_00542 HME7025_00542 606870 608060 - Xanthosine permease Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Nucleoside transport. To E. coli NupG and YegT gene gene-HME7025_00542 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00542 HME7025_00543 HME7025_00543 HME7025_00543 608368 608838 + hypothetical protein gene gene-HME7025_00543 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00543 HME7025_00544 HME7025_00544 mioX mioX 608894 609724 + Inositol oxygenase Ascorbate biosynthesis%3B Cytoplasm%3B Iron%3B Metal-binding%3B Oxidoreductase.%3B Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA)%2C providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis (By similarity)%3B Belongs to the myo-inositol oxygenase family%3B KEGG: scu:SCE1572_29535 inositol oxygenase gene gene-HME7025_00544 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00544 HME7025_00545 HME7025_00545 HME7025_00545 609795 610310 - hypothetical protein gene gene-HME7025_00545 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00545 HME7025_00546 HME7025_00546 HME7025_00546 610328 611557 - Serine-type D-Ala-D-Ala carboxypeptidase Cytoplasm%3B Hydrolase.%3B Acts on short-chain (C4-C6) fatty acid esters and triglycerides%2C including tertiary alcohol esters. Activity on p- nitrophenyl esters is generally higher than on o-nitrophenyl esters. Lacks beta-lactamase activit%3B it hydrolyzes the ester bond of cephalosporin substrates but there is no opening of the beta-lactam ring observed. Belongs to the class-A beta-lactamase family%3B KEGG: nbr:O3I_023425 D-alanyl-D-alanine carboxypeptidase gene gene-HME7025_00546 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00546 HME7025_00547 HME7025_00547 HME7025_00547 611712 611915 + Putative membrane protein insertion efficiency factor Cell inner membrane%3B Cell membrane%3B Membrane.%3B Could be involved in insertion of integral membrane proteins into the membrane%3B Belongs to the UPF0161 family gene gene-HME7025_00547 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00547 HME7025_00548 HME7025_00548 HME7025_00548 612362 615361 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_00548 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00548 HME7025_00549 HME7025_00549 HME7025_00549 615408 616877 + hypothetical protein gene gene-HME7025_00549 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00549 HME7025_00550 HME7025_00550 HME7025_00550 616981 620283 + hypothetical protein gene gene-HME7025_00550 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00550 HME7025_00551 HME7025_00551 HME7025_00551 620280 623609 + hypothetical protein gene gene-HME7025_00551 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00551 HME7025_00552 HME7025_00552 HME7025_00552 623613 625169 + hypothetical protein gene gene-HME7025_00552 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00552 HME7025_00553 HME7025_00553 HME7025_00553 625166 627661 + hypothetical protein gene gene-HME7025_00553 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00553 HME7025_00554 HME7025_00554 HME7025_00554 627661 628719 + hypothetical protein gene gene-HME7025_00554 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00554 HME7025_00555 HME7025_00555 HME7025_00555 628858 630639 + Short-chain acyl-CoA dehydrogenase FAD%3B Flavoprotein%3B Oxidoreductase.%3B Involved in the assimilation of dimethylsulphoniopropionate (DMSP)%2C an important compound in the fixation of carbon in marine phytoplankton%2C by mediating the conversion of 3-(methylthio)propanoyl-CoA (MMPA-CoA) to 3- (methylthio)acryloyl-CoA (MTA-CoA)%3B Belongs to the acyl-CoA dehydrogenase family%3B KEGG: fri:FraEuI1c_1657 butyryl-CoA dehydrogenase gene gene-HME7025_00555 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00555 HME7025_00556 HME7025_00556 pepN pepN 630652 632610 + Membrane alanyl aminopeptidase KEGG: chu:CHU_1442 aminopeptidase N gene gene-HME7025_00556 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00556 HME7025_00557 HME7025_00557 HME7025_00557 632718 633581 - Prephenate dehydrogenase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B NAD%3B Oxidoreductase%3B Tyrosine biosynthesis.%3B Contains 1 ACT domain%3B Contains 1 prephenate/arogenate dehydrogenase domain%3B KEGG: tas:TASI_0607 prephenate dehydrogenase gene gene-HME7025_00557 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00557 HME7025_00558 HME7025_00558 mtnE mtnE 633571 634746 - LL-diaminopimelate aminotransferase Aminotransferase%3B Pyridoxal phosphate%3B Transferase.%3B Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP)%2C required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate%2C a reaction that requires three enzymes in E. coli%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily%3B KEGG: blr:BRLA_c039280 aminotransferase%3B Transaminases gene gene-HME7025_00558 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00558 HME7025_00559 HME7025_00559 HME7025_00559 635343 646631 + Cartilage oligomeric matrix protein Apoptosis%3B Calcium%3B Cell adhesion%3B Disulfide bond%3B EGF-like domain%3B Extracellular matrix%3B Glycoprotein%3B Heparin-binding%3B Phosphoprotein%3B Repeat%3B Secreted%3B Signal.%3B May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3%2C BIRC2%2C BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity)%3B Belongs to the thrombospondin family%3B Contains 4 EGF-like domains%3B Contains 1 TSP C-terminal (TSPC) domain%3B Contains 8 TSP type-3 repeats gene gene-HME7025_00559 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00559 HME7025_00560 HME7025_00560 HME7025_00560 646654 647103 - Regulatory protein RecX Cytoplasm.%3B Modulates RecA activity%3B Belongs to the RecX family gene gene-HME7025_00560 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00560 HME7025_00561 HME7025_00561 hemA hemA 647110 648396 - Glutamyl-tRNA reductase NADP%3B Oxidoreductase%3B Porphyrin biosynthesis.%3B Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)%3B Belongs to the glutamyl-tRNA reductase family%3B KEGG: hym:N008_07650 glutamyl-tRNA reductase gene gene-HME7025_00561 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00561 HME7025_00562 HME7025_00562 fabG fabG 648501 649325 + 3-oxoacyl-[acyl-carrier-protein] reductase Acetylation%3B NADP%3B Oxidoreductase%3B Peroxisome.%3B Has apparently no steroid dehydrogenase activity%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B Contains 1 SCP2 domain%3B KEGG: ssu:SSU05_1803 3-oxoacyl-(acyl-carrier protein) reductase gene gene-HME7025_00562 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00562 HME7025_00563 HME7025_00563 HME7025_00563 649330 650325 + Putative esterase Hydrolase%3B Serine esterase.%3B Belongs to the AB hydrolase superfamily. AB hydrolase 4 family gene gene-HME7025_00563 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00563 HME7025_00564 HME7025_00564 serA serA 650315 652225 + Phosphoglycerate dehydrogenase Acetylation%3B Amino-acid biosynthesis%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Phosphoprotein%3B Serine biosynthesis.%3B Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity)%3B Belongs to the SerB family%3B KEGG: gfo:GFO_0734 D-3-phosphoglycerate dehydrogenase gene gene-HME7025_00564 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00564 HME7025_00565 HME7025_00565 serC serC 652230 653315 + Phosphoserine transaminase KEGG: chu:CHU_0995 phosphoserine aminotransferase gene gene-HME7025_00565 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00565 HME7025_00566 HME7025_00566 wlbA wlbA 653326 654318 + UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase Oxidoreductase.%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: swo:Swol_0706 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase gene gene-HME7025_00566 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00566 HME7025_00567 HME7025_00567 siaE siaE 654321 654977 + Sialate O-acetylesterase KEGG: bacc:BRDCF_02140 sialate O-acetylesterase gene gene-HME7025_00567 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00567 HME7025_00568 HME7025_00568 mutT mutT 654989 655735 + 8-oxo-dGTP diphosphatase KEGG: tmb:Thimo_2233 8-oxo-dGTP diphosphatase gene gene-HME7025_00568 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00568 HME7025_00569 HME7025_00569 HME7025_00569 655753 656709 - hypothetical protein gene gene-HME7025_00569 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00569 HME7025_00570 HME7025_00570 HME7025_00570 656672 657388 - putative transcriptional regulatory protein Cytoplasm%3B DNA-binding%3B Transcription%3B Transcription regulation.%3B Belongs to the TACO1 family gene gene-HME7025_00570 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00570 HME7025_00571 HME7025_00571 HME7025_00571 657571 659814 + hypothetical protein gene gene-HME7025_00571 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00571 HME7025_00572 HME7025_00572 HME7025_00572 659839 660345 + hypothetical protein gene gene-HME7025_00572 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00572 HME7025_00573 HME7025_00573 HME7025_00573 660485 660853 + Chemotaxis protein CheY Chemotaxis%3B Cytoplasm%3B Phosphoprotein%3B Two-component regulatory system.%3B Involved in the transmission of sensory signals from the chemoreceptors and photoreceptors to the flagellar motors%3B Contains 1 response regulatory domain gene gene-HME7025_00573 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00573 HME7025_00574 HME7025_00574 phnP phnP 660858 661631 + Phosphoribosyl 1%2C2-cyclic phosphate phosphodiesterase Acyltransferase%3B Cytoplasm%3B Transferase.%3B Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate%3B In the C-terminal sectio%3B belongs to the LipB family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: scd:Spica_1940 phosphoribosyl 1%2C2-cyclic phosphate phosphodiesterase gene gene-HME7025_00574 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00574 HME7025_00575 HME7025_00575 HME7025_00575 661631 662278 + Phosphoglycolate phosphatase Carbohydrate metabolism%3B Hydrolase%3B Magnesium%3B Metal-binding.%3B Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends%2C a major class of DNA lesions induced by oxidative stress%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: pae:PA3172 phosphoglycolate phosphatase gene gene-HME7025_00575 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00575 HME7025_00576 HME7025_00576 HME7025_00576 662419 665451 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_00576 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00576 HME7025_00577 HME7025_00577 HME7025_00577 665463 666887 + hypothetical protein gene gene-HME7025_00577 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00577 HME7025_00578 HME7025_00578 HME7025_00578 666989 669616 + hypothetical protein gene gene-HME7025_00578 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00578 HME7025_00579 HME7025_00579 accD accD 669692 670537 + Acetyl-CoA carboxylase ATP-binding%3B Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Ligase%3B Lipid biosynthesis%3B Lipid metabolism%3B Nucleotide-binding.%3B Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA%3B Belongs to the AccD/PCCB family%3B KEGG: rsi:Runsl_1775 acetyl-CoA carboxylase carboxyl transferase subunit beta gene gene-HME7025_00579 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00579 HME7025_00580 HME7025_00580 HME7025_00580 670594 671406 - hypothetical protein gene gene-HME7025_00580 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00580 HME7025_00581 HME7025_00581 HME7025_00581 671447 672538 - GTP cyclohydrolase 1 type 2 like protein Metal-binding.%3B Belongs to the GTP cyclohydrolase I type 2/NIF3 family gene gene-HME7025_00581 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00581 HME7025_00582 HME7025_00582 HME7025_00582 672637 673077 + 8-oxo-dGTP diphosphatase KEGG: syn:sll1045 8-oxo-dGTP diphosphatase gene gene-HME7025_00582 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00582 HME7025_00583 HME7025_00583 HME7025_00583 673052 674440 - High-affinity choline transporter Glycoprotein%3B Ion transport%3B Membrane%3B Neurotransmitter biosynthesis%3B Phosphoprotein%3B Sodium%3B Sodium transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent%3B Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene-HME7025_00583 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00583 HME7025_00584 HME7025_00584 HME7025_00584 674515 675789 + hypothetical protein gene gene-HME7025_00584 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00584 HME7025_00585 HME7025_00585 HME7025_00585 675827 677065 - Putative xylose repressor Carbohydrate metabolism%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Xylose metabolism.%3B Transcriptional repressor of xylose-utilizing enzymes%3B Belongs to the ROK (NagC/XylR) family gene gene-HME7025_00585 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00585 HME7025_00586 HME7025_00586 HME7025_00586 677245 678612 - hypothetical protein gene gene-HME7025_00586 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00586 HME7025_00587 HME7025_00587 HME7025_00587 678630 679895 + hypothetical protein gene gene-HME7025_00587 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00587 HME7025_00588 HME7025_00588 HME7025_00588 679892 681010 - hypothetical protein gene gene-HME7025_00588 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00588 HME7025_00589 HME7025_00589 HME7025_00589 681161 681400 + 50S ribosomal protein L28 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L28P family gene gene-HME7025_00589 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00589 HME7025_00590 HME7025_00590 HME7025_00590 681463 682566 + putative molybdopterin-synthase adenylyltransferase ATP-binding%3B Chloroplast%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Plastid%3B Transferase.%3B Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD%3B Belongs to the HesA/MoeB/ThiF family%3B Contains 1 rhodanese domain gene gene-HME7025_00590 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00590 HME7025_00591 HME7025_00591 rimO rimO 682563 683888 - [Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12%3B Belongs to the methylthiotransferase family. RimO subfamily%3B Contains 1 MTTase N-terminal domain%3B Contains 1 TRAM domain%3B KEGG: bfr:BF2425 ribosomal protein S12 methylthiotransferase gene gene-HME7025_00591 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00591 HME7025_00592 HME7025_00592 HME7025_00592 684031 684735 + hypothetical protein gene gene-HME7025_00592 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00592 HME7025_00593 HME7025_00593 HME7025_00593 684948 685250 + hypothetical protein gene gene-HME7025_00593 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00593 HME7025_00594 HME7025_00594 HME7025_00594 685257 686129 + hypothetical protein gene gene-HME7025_00594 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00594 HME7025_00595 HME7025_00595 HME7025_00595 686659 687555 - hypothetical protein gene gene-HME7025_00595 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00595 HME7025_00596 HME7025_00596 HME7025_00596 687855 688280 + hypothetical protein gene gene-HME7025_00596 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00596 HME7025_00597 HME7025_00597 HME7025_00597 688304 689104 + hypothetical protein gene gene-HME7025_00597 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00597 HME7025_00598 HME7025_00598 HME7025_00598 689260 690228 - Gluconolactonase Hydrolase%3B Periplasm%3B Serine esterase%3B Signal.%3B KEGG: dfe:Dfer_2426 gluconolactonase gene gene-HME7025_00598 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00598 HME7025_00599 HME7025_00599 HME7025_00599 690340 692052 - Gluconate 2-dehydrogenase (acceptor) Cell membrane%3B FAD%3B Flavoprotein%3B Membrane%3B Oxidoreductase.%3B Catalytic subunit of fructose dehydrogenase%2C an enzyme that catalyzes the oxidation of D-fructose to produce 5-keto-D- fructose%3B Belongs to the GMC oxidoreductase family%3B KEGG: hlr:HALLA_07515 gluconate 2-dehydrogenase alpha chain gene gene-HME7025_00599 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00599 HME7025_00600 HME7025_00600 HME7025_00600 692078 692653 - hypothetical protein gene gene-HME7025_00600 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00600 HME7025_00601 HME7025_00601 hemK hemK 692814 693668 + Peptide chain release factor N(5)-glutamine methyltransferase Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase.%3B Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif%3B Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily%3B KEGG: shl:Shal_3210 release factor glutamine methyltransferase gene gene-HME7025_00601 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00601 HME7025_00602 HME7025_00602 HME7025_00602 693685 694392 + Protein LemA Cell membrane%3B Coiled coil%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the LemA family gene gene-HME7025_00602 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00602 HME7025_00603 HME7025_00603 HME7025_00603 694395 694820 + hypothetical protein gene gene-HME7025_00603 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00603 HME7025_00604 HME7025_00604 HME7025_00604 694867 695583 + UPF0603 protein YgcG Cell membrane%3B Membrane%3B Signal%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0603 family gene gene-HME7025_00604 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00604 HME7025_00605 HME7025_00605 gmhA gmhA 695598 696182 + D-sedoheptulose 7-phosphate isomerase Carbohydrate metabolism%3B Cytoplasm%3B Isomerase%3B Metal-binding%3B Zinc.%3B Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate%3B Belongs to the SIS family. GmhA subfamily%3B Contains 1 SIS domain%3B KEGG: str:Sterm_2784 D-sedoheptulose 7-phosphate isomerase gene gene-HME7025_00605 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00605 HME7025_00606 HME7025_00606 HME7025_00606 696311 697636 - Cell division protein FtsA Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Membrane.%3B Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring%3B Belongs to the FtsA/MreB family gene gene-HME7025_00606 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00606 HME7025_00607 HME7025_00607 HME7025_00607 697703 698494 - hypothetical protein gene gene-HME7025_00607 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00607 HME7025_00608 HME7025_00608 murC murC 698508 699884 - UDP-N-acetylmuramate--L-alanine ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Peptidoglycan synthesis.%3B Cell wall formation%3B Belongs to the MurCDEF family%3B KEGG: tnr:Thena_0666 UDP-N-acetylmuramate--alanine ligase gene gene-HME7025_00608 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00608 HME7025_00609 HME7025_00609 murG murG 699874 700986 - Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Glycosyltransferase%3B Membrane%3B Peptidoglycan synthesis%3B Transferase.%3B Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)%3B Belongs to the glycosyltransferase 28 family. MurG subfamily%3B KEGG: dsf:UWK_03486 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase gene gene-HME7025_00609 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00609 HME7025_00610 HME7025_00610 HME7025_00610 700986 702161 - Cell division protein FtsW like protein Cell cycle%3B Cell division%3B Cell shape%3B Chloroplast%3B Membrane%3B Plastid%3B Transmembrane%3B Transmembrane helix.%3B Could play a role in chloroplast division/peptidoglycan biosynthesis. Belongs to the SEDS family gene gene-HME7025_00610 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00610 HME7025_00611 HME7025_00611 murD murD 702151 703485 - UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Peptidoglycan synthesis.%3B Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)%3B Belongs to the MurCDEF family%3B KEGG: bfr:BF0308 UDP-N-acetylmuramoylalanine--D-glutamate ligase gene gene-HME7025_00611 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00611 HME7025_00612 HME7025_00612 HME7025_00612 703735 704568 - Elongation factor Ts Cytoplasm%3B Elongation factor%3B Protein biosynthesis.%3B Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA. EF- Tu. GTP complex up to the GTP hydrolysis stage on the ribosome%3B Belongs to the EF-Ts family gene gene-HME7025_00612 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00612 HME7025_00613 HME7025_00613 HME7025_00613 704582 705391 - 30S ribosomal protein S2%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein S2P family gene gene-HME7025_00613 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00613 HME7025_00614 HME7025_00614 HME7025_00614 705473 705862 - 30S ribosomal protein S9 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein S9P family gene gene-HME7025_00614 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00614 HME7025_00615 HME7025_00615 HME7025_00615 705902 706345 - 50S ribosomal protein L13 Ribonucleoprotein%3B Ribosomal protein.%3B This protein is one of the early assembly proteins of the 50S ribosomal subunit%2C although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly%3B Belongs to the ribosomal protein L13P family gene gene-HME7025_00615 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00615 HME7025_00616 HME7025_00616 accC accC 706573 707916 - Acetyl-CoA carboxylase ATP-binding%3B Biotin%3B Ligase%3B Magnesium%3B Nucleotide-binding.%3B Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B KEGG: wgl:WIGMOR_0138 acetyl-CoA carboxylase%2C biotin carboxylase subunit gene gene-HME7025_00616 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00616 HME7025_00617 HME7025_00617 HME7025_00617 707963 708427 - Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1%2C chloroplastic Alternative splicing%3B Biotin%3B Chloroplast%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Plastid%3B Transit peptide.%3B This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. Contains 1 biotinyl-binding domain gene gene-HME7025_00617 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00617 HME7025_00618 HME7025_00618 HME7025_00618 708494 709057 - Elongation factor Cytoplasm%3B Elongation factor%3B Protein biosynthesis.%3B Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA%2C thus increasing their reactivity as acceptors for peptidyl transferase%3B Belongs to the elongation factor P family gene gene-HME7025_00618 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00618 HME7025_00619 HME7025_00619 fabH fabH 709073 710074 - Beta-ketoacyl-[acyl-carrier-protein] synthase III Acyltransferase%3B Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Multifunctional enzyme%3B Transferase.%3B Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids%3B Belongs to the FabH family%3B KEGG: fli:Fleli_3161 3-oxoacyl-(acyl-carrier-protein) synthase III gene gene-HME7025_00619 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00619 HME7025_00620 HME7025_00620 plsX plsX 710098 711042 - Glycerol-3-phosphate 1-O-acyltransferase Cytoplasm%3B Lipid biosynthesis%3B Lipid metabolism%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase.%3B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor%2C but not acyl-CoA%3B Belongs to the PlsX family%3B KEGG: ece:Z1729 glycerol-3-phosphate acyltransferase PlsX gene gene-HME7025_00620 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00620 HME7025_00621 HME7025_00621 HME7025_00621 711171 711359 - 50S ribosomal protein L32 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L32P family gene gene-HME7025_00621 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00621 HME7025_00622 HME7025_00622 HME7025_00622 711382 711921 - hypothetical protein gene gene-HME7025_00622 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00622 HME7025_00623 HME7025_00623 bcrC bcrC 712020 712655 + Undecaprenyl-diphosphate phosphatase KEGG: apr:Apre_0639 undecaprenyl-diphosphatase gene gene-HME7025_00623 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00623 HME7025_00624 HME7025_00624 arnT arnT 712633 714291 + Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase KEGG: amo:Anamo_1886 4-amino-4-deoxy-L-arabinose transferase gene gene-HME7025_00624 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00624 HME7025_00625 HME7025_00625 HME7025_00625 714292 714711 - Nucleoside-diphosphate kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide metabolism%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase.%3B Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism%2C using a phosphorylated active-site intermediate%3B Belongs to the NDK family%3B KEGG: pfq:QQ39_13625 nucleoside-diphosphate kinase gene gene-HME7025_00625 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00625 HME7025_00626 HME7025_00626 HME7025_00626 714784 715812 + hypothetical protein gene gene-HME7025_00626 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00626 HME7025_00627 HME7025_00627 fkpA fkpA 715865 716728 + Peptidylprolyl isomerase Isomerase%3B Periplasm%3B Rotamase%3B Signal.%3B PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: nko:Niako_4633 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA gene gene-HME7025_00627 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00627 HME7025_00628 HME7025_00628 HME7025_00628 716829 717701 + Peptidylprolyl isomerase Isomerase%3B Nucleus%3B Phosphoprotein%3B Rotamase.%3B PPIases accelerate the folding of proteins. May function in a signal transduction cascade during early development. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: ppk:U875_14705 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA gene gene-HME7025_00628 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00628 HME7025_00629 HME7025_00629 HME7025_00629 717707 718603 + Peptidylprolyl isomerase Endoplasmic reticulum%3B Isomerase%3B Rotamase%3B Signal.%3B PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)%3B Belongs to the FKBP-type PPIase family. FKBP2 subfamily%3B Contains 1 PPIase FKBP-type domain%3B KEGG: xsa:SB85_20065 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA gene gene-HME7025_00629 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00629 HME7025_00630 HME7025_00630 HME7025_00630 718608 719207 + XTP/dITP diphosphatase Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide metabolism%3B Nucleotide-binding.%3B Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool%2C thus preventing their incorporation into DNA and avoiding chromosomal lesions%3B Belongs to the HAM1 NTPase family%3B KEGG: aps:CFPG_594 XTP/dITP diphosphohydrolase gene gene-HME7025_00630 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00630 HME7025_00631 HME7025_00631 HME7025_00631 719263 721803 + hypothetical protein gene gene-HME7025_00631 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00631 HME7025_00632 HME7025_00632 plsY plsY 721937 722581 + Glycerol-3-phosphate 1-O-acyltransferase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor%2C but not acyl-CoA or acyl-ACP%3B Belongs to the PlsY family%3B KEGG: pfq:QQ39_14765 glycerol-3-phosphate acyltransferase PlsY gene gene-HME7025_00632 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00632 HME7025_00633 HME7025_00633 HME7025_00633 722636 724009 + Succinyl-diaminopimelate desuccinylase Amino-acid biosynthesis%3B Cobalt%3B Diaminopimelate biosynthesis%3B Hydrolase%3B Lysine biosynthesis%3B Metal-binding%3B Zinc.%3B Catalyzes the hydrolysis of N-succinyl-L%2CL- diaminopimelic acid (SDAP)%2C forming succinate and LL-2%2C6- diaminoheptanedioate (DAP)%2C an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid%2C an essential component of bacterial cell walls%3B Belongs to the peptidase M20A family. DapE subfamily%3B KEGG: bme:BMEI1827 amidohydrolase%3B In linear amides gene gene-HME7025_00633 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00633 HME7025_00634 HME7025_00634 murQ murQ 724009 724836 + N-acetylmuramic acid 6-phosphate etherase Carbohydrate metabolism%3B Lyase.%3B Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate%2C producing GlcNAc 6- phosphate and D-lactate. Together with AnmK%2C is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling (By similarity)%3B Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily%3B Contains 1 SIS domain%3B KEGG: eol:Emtol_1598 N-acetylmuramic acid 6-phosphate etherase gene gene-HME7025_00634 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00634 HME7025_00635 HME7025_00635 HME7025_00635 724921 725247 + hypothetical protein gene gene-HME7025_00635 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00635 HME7025_00636 HME7025_00636 coaE coaE 725302 725832 - Dephospho-CoA kinase KEGG: pdt:Prede_1602 dephospho-CoA kinase gene gene-HME7025_00636 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00636 HME7025_00637 HME7025_00637 HME7025_00637 725862 726479 - putative GTP-binding protein EngB Cell cycle%3B Cell division%3B GTP-binding%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Septation.%3B Necessary for normal cell division and for the maintenance of normal septation%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family%3B Contains 1 EngB-type G (guanine nucleotide-binding) domain gene gene-HME7025_00637 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00637 HME7025_00638 HME7025_00638 hemE hemE 727303 728334 + Uroporphyrinogen decarboxylase Cytoplasm%3B Decarboxylase%3B Lyase%3B Porphyrin biosynthesis.%3B Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III%3B Belongs to the uroporphyrinogen decarboxylase family%3B KEGG: psal:PSLF89_3305 uroporphyrinogen decarboxylase gene gene-HME7025_00638 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00638 HME7025_00639 HME7025_00639 guaB guaB 728531 730000 - IMP dehydrogenase CBS domain%3B GMP biosynthesis%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Potassium%3B Purine biosynthesis%3B Repeat.%3B Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP)%2C the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides%2C and therefore plays an important role in the regulation of cell growth%3B Belongs to the IMPDH/GMPR family%3B Contains 2 CBS domains%3B KEGG: sli:Slin_1193 IMP dehydrogenase gene gene-HME7025_00639 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00639 HME7025_00640 HME7025_00640 HME7025_00640 730099 731100 + hypothetical protein gene gene-HME7025_00640 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00640 HME7025_00641 HME7025_00641 HME7025_00641 731114 732076 + hypothetical protein gene gene-HME7025_00641 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00641 HME7025_00642 HME7025_00642 HME7025_00642 732102 733451 + hypothetical protein gene gene-HME7025_00642 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00642 HME7025_00643 HME7025_00643 nuoA nuoA 733517 733885 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 3 family%3B KEGG: hsw:Hsw_0542 NADH-quinone oxidoreductase subunit A gene gene-HME7025_00643 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00643 HME7025_00644 HME7025_00644 HME7025_00644 733935 734483 + NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 20 kDa subunit family%3B KEGG: fae:FAES_0776 NADH-quinone oxidoreductase subunit B gene gene-HME7025_00644 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00644 HME7025_00645 HME7025_00645 HME7025_00645 734495 735004 + NADH:ubiquinone reductase (H(+)-translocating) Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 30 kDa subunit family%3B KEGG: dfe:Dfer_4086 NADH-quinone oxidoreductase subunit C gene gene-HME7025_00645 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00645 HME7025_00646 HME7025_00646 nuoD nuoD 735026 736261 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 49 kDa subunit family%3B KEGG: sli:Slin_5101 NADH-quinone oxidoreductase subunit D gene gene-HME7025_00646 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00646 HME7025_00647 HME7025_00647 nuoE nuoE 736265 736759 + NADH:ubiquinone reductase (H(+)-translocating) 2Fe-2S%3B Cell inner membrane%3B Cell membrane%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Ubiquinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient. Belongs to the complex I 24 kDa subunit family%3B KEGG: bgl:bglu_1g25900 NADH-quinone oxidoreductase subunit E gene gene-HME7025_00647 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00647 HME7025_00648 HME7025_00648 nuoF nuoF 736766 738106 + NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Cell membrane%3B Flavoprotein%3B FMN%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The nqo1 subunit contains the NADH-binding site and the primary electron acceptor FMN. Belongs to the complex I 51 kDa subunit family%3B KEGG: hhy:Halhy_0321 NADH-quinone oxidoreductase subunit F gene gene-HME7025_00648 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00648 HME7025_00649 HME7025_00649 HME7025_00649 738109 739269 + hypothetical protein gene gene-HME7025_00649 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00649 HME7025_00650 HME7025_00650 nuoG nuoG 739310 740341 + NADH:ubiquinone reductase (H(+)-translocating) 2Fe-2S%3B 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I 75 kDa subunit family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: scn:Solca_3734 NADH-quinone oxidoreductase subunit G gene gene-HME7025_00650 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00650 HME7025_00651 HME7025_00651 nuoH nuoH 740347 741471 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Ubiquinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone%3B Belongs to the complex I subunit 1 family%3B KEGG: ipa:Isop_3645 NADH-quinone oxidoreductase subunit H gene gene-HME7025_00651 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00651 HME7025_00652 HME7025_00652 HME7025_00652 741476 741994 + NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Repeat%3B Ubiquinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 23 kDa subunit family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: nso:NIASO_11620 NADH-quinone oxidoreductase subunit I gene gene-HME7025_00652 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00652 HME7025_00653 HME7025_00653 nuoJ nuoJ 742003 742518 + NADH:ubiquinone reductase (H(+)-translocating) Electron transport%3B Membrane%3B Mitochondrion%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone.%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)%3B Belongs to the complex I subunit 6 family%3B KEGG: cvi:CV_0950 NADH-quinone oxidoreductase subunit J gene gene-HME7025_00653 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00653 HME7025_00654 HME7025_00654 HME7025_00654 742588 743124 - hypothetical protein gene gene-HME7025_00654 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00654 HME7025_00655 HME7025_00655 HME7025_00655 743336 744010 - hypothetical protein gene gene-HME7025_00655 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00655 HME7025_00656 HME7025_00656 HME7025_00656 744242 745303 + Histidine kinase Contains 1 response regulatory domain%3B KEGG: amd:AMED_0131 two-component system%2C LytT family%2C sensor kinase gene gene-HME7025_00656 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00656 HME7025_00657 HME7025_00657 HME7025_00657 745308 746054 + putative response regulatory protein DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system.%3B Contains 1 HTH LytTR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene-HME7025_00657 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00657 HME7025_00658 HME7025_00658 HME7025_00658 746055 748064 - hypothetical protein gene gene-HME7025_00658 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00658 HME7025_00659 HME7025_00659 HME7025_00659 748064 748828 - hypothetical protein gene gene-HME7025_00659 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00659 HME7025_00660 HME7025_00660 wbyL wbyL 748851 749615 - putative glycosyltransferase Glycosyltransferase%3B Transferase.%3B Belongs to the glycosyltransferase 2 family%3B KEGG: ype:YPO3098 glycosyltransferase%3B Hexosyltransferases gene gene-HME7025_00660 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00660 HME7025_00661 HME7025_00661 HME7025_00661 749618 750889 - N-acetyl-alpha-D-glucosaminyl L-malate synthase Glycosyltransferase%3B Nucleotide-binding%3B Transferase.%3B Involved in bacillithiol (BSH) biosynthesis. Catalyzes the first step of the pathway%2C the formation of N- acetylglucosaminylmalate (GlcNAc-Mal) from UDP-N-acetylglucosamine (UDP-GlcNAc) and L-malate%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: synp:Syn7502_00272 UDP-glucose:tetrahydrobiopterin glucosyltransferase%3B Hexosyltransferases gene gene-HME7025_00661 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00661 HME7025_00662 HME7025_00662 wecB wecB 750886 751989 - UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) Cell wall biogenesis/degradation%3B Isomerase%3B Lipopolysaccharide biosynthesis.%3B Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the epimerization of UDP-2%2C3-diacetamido- 2%2C3-dideoxy-alpha-D-glucuronic acid (UDP-alpha-D-GlcNAc3NAcA) to UDP-2%2C3-diacetamido-2%2C3-dideoxy-alpha-D-mannuronic acid (UDP- alpha-D-ManNAc3NAcA). Exhibits high specificity towards the substrate as UDP-alpha-D-GlcNAc%2C UDP-alpha-D-GlcNAcA (UDP-2- acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D- GlcNAc3NAc (UDP-2%2C3-diacetamido-2%2C3-dideoxy-alpha-D-glucose) cannot act as substrates%3B Belongs to the UDP-N-acetylglucosamine 2-epimerase family%3B KEGG: hhy:Halhy_3405 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) gene gene-HME7025_00662 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00662 HME7025_00663 HME7025_00663 HME7025_00663 752018 753241 - hypothetical protein gene gene-HME7025_00663 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00663 HME7025_00664 HME7025_00664 HME7025_00664 753238 754734 - hypothetical protein gene gene-HME7025_00664 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00664 HME7025_00665 HME7025_00665 wcaL wcaL 754795 755898 - Putative colanic acid biosynthesis glycosyltransferase WcaL Glycosyltransferase%3B Lipopolysaccharide biosynthesis%3B Transferase.%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: eco:b2044 colanic acid/amylovoran biosynthesis glycosyltransferase%3B Glycosyltransferases gene gene-HME7025_00665 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00665 HME7025_00666 HME7025_00666 galE galE 756007 756936 + UDP-glucose 4-epimerase Carbohydrate metabolism%3B Galactose metabolism%3B Isomerase%3B NAD.%3B Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: dvm:DvMF_0137 UDP-glucose 4-epimerase gene gene-HME7025_00666 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00666 HME7025_00667 HME7025_00667 HME7025_00667 757087 757788 - hypothetical protein gene gene-HME7025_00667 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00667 HME7025_00668 HME7025_00668 HME7025_00668 757791 758903 - hypothetical protein gene gene-HME7025_00668 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00668 HME7025_00669 HME7025_00669 pqqL pqqL 758997 760238 + putative zinc protease Cell membrane%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Plasmid%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Zinc.%3B Belongs to the peptidase M16 family%3B KEGG: pzu:PHZ_c3416 zinc protease%3B Metalloendopeptidases gene gene-HME7025_00669 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00669 HME7025_00670 HME7025_00670 ispF ispF 760241 760720 + 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase Isoprene biosynthesis%3B Lyase%3B Metal-binding%3B Multifunctional enzyme%3B Nucleotidyltransferase%3B Transferase.%3B Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD)%2C and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2%2C4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)%3B In the N-terminal sectio%3B belongs to the IspD family%3B In the C-terminal sectio%3B belongs to the IspF family%3B KEGG: xfa:XF1294 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase gene gene-HME7025_00670 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00670 HME7025_00671 HME7025_00671 relA relA 760724 762973 + GTP diphosphokinase Antibiotic biosynthesis%3B ATP-binding%3B GTP-binding%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). Is required for actinomycin production%3B Belongs to the RelA/SpoT family%3B Contains 1 ACT domain%3B Contains 1 HD domain%3B KEGG: chu:CHU_1704 GTP pyrophosphokinase gene gene-HME7025_00671 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00671 HME7025_00672 HME7025_00672 HME7025_00672 763023 763508 + Peroxide-responsive repressor PerR Cytoplasm%3B DNA-binding%3B Manganese%3B Metal-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Zinc.%3B Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity)%3B Belongs to the Fur family gene gene-HME7025_00672 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00672 HME7025_00673 HME7025_00673 purA purA 763530 764810 + Adenylosuccinate synthase Cytoplasm%3B GTP-binding%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Purine biosynthesis.%3B Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP%3B Belongs to the adenylosuccinate synthetase family%3B KEGG: bth:BT_1843 adenylosuccinate synthase gene gene-HME7025_00673 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00673 HME7025_00674 HME7025_00674 HME7025_00674 764818 765459 + hypothetical protein gene gene-HME7025_00674 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00674 HME7025_00675 HME7025_00675 kae1 kae1 765524 766525 - N(6)-L-threonylcarbamoyladenine synthase Acyltransferase%3B Cytoplasm%3B Iron%3B Metal-binding%3B Transferase%3B tRNA processing.%3B Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction%3B Belongs to the KAE1 / TsaD family%3B KEGG: cpi:Cpin_3372 N6-L-threonylcarbamoyladenine synthase gene gene-HME7025_00675 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00675 HME7025_00676 HME7025_00676 HME7025_00676 766595 771058 + hypothetical protein gene gene-HME7025_00676 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00676 HME7025_00677 HME7025_00677 HME7025_00677 771823 772074 + hypothetical protein gene gene-HME7025_00677 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00677 HME7025_00678 HME7025_00678 HME7025_00678 772099 772350 + hypothetical protein gene gene-HME7025_00678 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00678 HME7025_00679 HME7025_00679 HME7025_00679 772347 772565 + hypothetical protein gene gene-HME7025_00679 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00679 HME7025_00680 HME7025_00680 HME7025_00680 772688 773629 - hypothetical protein gene gene-HME7025_00680 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00680 HME7025_00681 HME7025_00681 nadB nadB 773735 775324 + L-aspartate oxidase Electron transport%3B FAD%3B Flavoprotein%3B Oxidoreductase%3B Transport.%3B Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily%3B KEGG: dfe:Dfer_4734 L-aspartate oxidase gene gene-HME7025_00681 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00681 HME7025_00682 HME7025_00682 HME7025_00682 775310 775939 - Uridine kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Belongs to the uridine kinase family%3B KEGG: oih:OB2003 uridine kinase gene gene-HME7025_00682 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00682 HME7025_00683 HME7025_00683 HME7025_00683 776007 776543 - hypothetical protein gene gene-HME7025_00683 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00683 HME7025_00684 HME7025_00684 HME7025_00684 776616 776831 + hypothetical protein gene gene-HME7025_00684 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00684 HME7025_00685 HME7025_00685 HME7025_00685 777313 777816 + Gamma carbonic anhydrase 2%2C mitochondrial Lyase%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Transit peptide%3B Zinc.%3B Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide (PubMed:19808034). Mediates complex I assembly in mitochondria and respiration. Binds HCO(3)-. Required for male fertility during anther development and dehiscence to regulate the secondary thickenings of the endothecial cell wall%2C probably by modulating H(2)O(2)-dependent lignin polymerization%3B Belongs to the gamma-class carbonic anhydrase family gene gene-HME7025_00685 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00685 HME7025_00686 HME7025_00686 HME7025_00686 777813 778289 + hypothetical protein gene gene-HME7025_00686 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00686 HME7025_00687 HME7025_00687 HME7025_00687 778289 778420 + hypothetical protein gene gene-HME7025_00687 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00687 HME7025_00688 HME7025_00688 HME7025_00688 778514 779677 + hypothetical protein gene gene-HME7025_00688 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00688 HME7025_00689 HME7025_00689 HME7025_00689 779893 780834 + hypothetical protein gene gene-HME7025_00689 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00689 HME7025_00690 HME7025_00690 HME7025_00690 780852 781370 - Putative metal-dependent hydrolase Cytoplasm%3B Hydrolase%3B Metal-binding%3B Zinc.%3B Possible metal-dependent hydrolase%3B Belongs to the metal hydrolase YfiT family gene gene-HME7025_00690 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00690 HME7025_00691 HME7025_00691 HME7025_00691 781375 783093 - D-alanine--D-alanine ligase ATP-binding%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide-binding%3B Peptidoglycan synthesis.%3B Cell wall formation%3B Belongs to the D-alanine--D-alanine ligase family%3B Contains 1 ATP-grasp domain%3B KEGG: fli:Fleli_0247 D-alanine-D-alanine ligase gene gene-HME7025_00691 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00691 HME7025_00692 HME7025_00692 HME7025_00692 783099 783353 - Fe/S bioproteinis protein NfuA 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding.%3B Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster%2C can transfer this cluster to apoproteins%2C and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins%3B Belongs to the NfuA family gene gene-HME7025_00692 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00692 HME7025_00693 HME7025_00693 HME7025_00693 783357 784439 - Iron-sulfur cluster carrier protein ATP-binding%3B Hydrolase%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Nucleotide-binding.%3B Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP%3B In the N-terminal sectio%3B belongs to the MIP18 family%3B In the C-terminal sectio%3B belongs to the Mrp/NBP35 ATP-binding proteins family gene gene-HME7025_00693 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00693 HME7025_00694 HME7025_00694 HME7025_00694 784503 785474 - hypothetical protein gene gene-HME7025_00694 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00694 HME7025_00695 HME7025_00695 HME7025_00695 785767 788406 + uncharacterized protein Phosphoprotein. gene gene-HME7025_00695 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00695 HME7025_00696 HME7025_00696 HME7025_00696 788399 788872 + Protein TCP17 Cytoplasm. gene gene-HME7025_00696 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00696 HME7025_00697 HME7025_00697 nadA nadA 789140 790126 - Quinolinate synthase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Pyridine nucleotide biosynthesis%3B Transferase.%3B Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate%3B Belongs to the quinolinate synthase A family. Type 2 subfamily%3B KEGG: aay:WYH_01531 quinolinate synthase gene gene-HME7025_00697 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00697 HME7025_00698 HME7025_00698 nadC nadC 790123 790983 - Nicotinate-nucleotide diphosphorylase (carboxylating) Alternative splicing%3B Chloroplast%3B Glycosyltransferase%3B Plastid%3B Pyridine nucleotide biosynthesis%3B Transferase%3B Transit peptide.%3B Involved in the catabolism of quinolinic acid (QA)%3B Belongs to the NadC/ModD family%3B KEGG: wvi:Weevi_0891 nicotinate-nucleotide pyrophosphorylase (carboxylating) gene gene-HME7025_00698 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00698 HME7025_00699 HME7025_00699 HME7025_00699 791077 791430 + hypothetical protein gene gene-HME7025_00699 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00699 HME7025_00700 HME7025_00700 HME7025_00700 791490 794417 + Protein translocase subunit SecD Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecD subfamily gene gene-HME7025_00700 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00700 HME7025_00701 HME7025_00701 HME7025_00701 794483 795961 + putative amino acid permease YfnA Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene-HME7025_00701 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00701 HME7025_00702 HME7025_00702 HME7025_00702 796049 797641 + Peptide chain release factor Cytoplasm%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis.%3B Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP%2C but not by GMP%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene-HME7025_00702 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00702 HME7025_00703 HME7025_00703 HME7025_00703 797829 799583 - Phosphoglucomutase (alpha-D-glucose-1%2C6-bisphosphate-dependent) Carbohydrate metabolism%3B Glucose metabolism%3B Isomerase%3B Magnesium%3B Metal-binding%3B Phosphoprotein.%3B Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG)%2C i. e. the predominant glycolipid found in B. subtilis membrane%2C which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers%2C since glucose-1-phosphate is the precursor of UDP-glucose%2C which serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required for biofilm formation. This is likely due to another role of UDP-glucose%2C which might also act as a metabolic signal regulating biofilm formation or may be involved in some unknown biosynthetic pathway essential for biofilm formation%2C e. g. the synthesis of an exopolysaccharide%3B Belongs to the phosphohexose mutase family%3B KEGG: phe:Phep_2334 phosphoglucomutase gene gene-HME7025_00703 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00703 HME7025_00704 HME7025_00704 HME7025_00704 799691 801475 + hypothetical protein gene gene-HME7025_00704 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00704 HME7025_00705 HME7025_00705 dapF dapF 801462 802235 - Diaminopimelate epimerase Amino-acid biosynthesis%3B Cytoplasm%3B Disulfide bond%3B Isomerase%3B Lysine biosynthesis.%3B Catalyzes the stereoinversion of LL-2%2C6- diaminoheptanedioate (L%2CL-DAP) to meso-diaminoheptanedioate (meso- DAP)%2C a precursor of L-lysine and an essential component of the bacterial peptidoglycan%3B Belongs to the diaminopimelate epimerase family%3B KEGG: csr:Cspa_c26460 diaminopimelate epimerase gene gene-HME7025_00705 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00705 HME7025_00706 HME7025_00706 HME7025_00706 802420 802938 - hypothetical protein gene gene-HME7025_00706 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00706 HME7025_00707 HME7025_00707 HME7025_00707 803012 803088 + tRNA-Asp tRNA gene-HME7025_00707 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00707 HME7025_00708 HME7025_00708 HME7025_00708 803278 804687 + hypothetical protein gene gene-HME7025_00708 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00708 HME7025_00709 HME7025_00709 HME7025_00709 804694 804858 - hypothetical protein gene gene-HME7025_00709 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00709 HME7025_00710 HME7025_00710 HME7025_00710 805030 805371 - hypothetical protein gene gene-HME7025_00710 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00710 HME7025_00711 HME7025_00711 HME7025_00711 805316 805627 - hypothetical protein gene gene-HME7025_00711 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00711 HME7025_00712 HME7025_00712 HME7025_00712 806238 806459 + hypothetical protein gene gene-HME7025_00712 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00712 HME7025_00713 HME7025_00713 HME7025_00713 806912 807640 - 8-oxo-dGTP diphosphatase KEGG: sht:KO02_11075 8-oxo-dGTP diphosphatase gene gene-HME7025_00713 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00713 HME7025_00714 HME7025_00714 HME7025_00714 807851 808228 + hypothetical protein gene gene-HME7025_00714 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00714 HME7025_00715 HME7025_00715 HME7025_00715 808302 808667 - hypothetical protein gene gene-HME7025_00715 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00715 HME7025_00716 HME7025_00716 pepP pepP 808675 810072 - Xaa-Pro aminopeptidase Aminopeptidase%3B Hydrolase%3B Manganese%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Mitochondrion%3B Mitochondrion inner membrane%3B Protease%3B Transit peptide.%3B Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome%3B Belongs to the peptidase M24B family%3B KEGG: lan:Lacal_2384 Xaa-Pro aminopeptidase gene gene-HME7025_00716 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00716 HME7025_00717 HME7025_00717 HME7025_00717 810194 810694 - hypothetical protein gene gene-HME7025_00717 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00717 HME7025_00718 HME7025_00718 panE panE 810769 811725 - 2-dehydropantoate 2-reductase NADP%3B Oxidoreductase.%3B Belongs to the ketopantoate reductase family%3B KEGG: fps:FP1582 2-dehydropantoate 2-reductase gene gene-HME7025_00718 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00718 HME7025_00719 HME7025_00719 HME7025_00719 811741 812253 - hypothetical protein gene gene-HME7025_00719 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00719 HME7025_00720 HME7025_00720 HME7025_00720 812250 813341 - hypothetical protein gene gene-HME7025_00720 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00720 HME7025_00721 HME7025_00721 HME7025_00721 813380 813661 - hypothetical protein gene gene-HME7025_00721 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00721 HME7025_00722 HME7025_00722 HME7025_00722 813711 814301 - putative HTH-type transcriptional regulator in lacX 3'region DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH tetR-type DNA-binding domain gene gene-HME7025_00722 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00722 HME7025_00723 HME7025_00723 HME7025_00723 814543 815787 + Esterase EstB Cytoplasm%3B Hydrolase.%3B Acts on short-chain (C4-C6) fatty acid esters and triglycerides%2C including tertiary alcohol esters. Activity on p- nitrophenyl esters is generally higher than on o-nitrophenyl esters. Lacks beta-lactamase activit%3B it hydrolyzes the ester bond of cephalosporin substrates but there is no opening of the beta-lactam ring observed. Belongs to the class-A beta-lactamase family gene gene-HME7025_00723 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00723 HME7025_00724 HME7025_00724 phoD phoD 815875 817143 + Alkaline phosphatase Signal.%3B KEGG: bac:BamMC406_4384 alkaline phosphatase D gene gene-HME7025_00724 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00724 HME7025_00725 HME7025_00725 HME7025_00725 817296 820604 + hypothetical protein gene gene-HME7025_00725 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00725 HME7025_00726 HME7025_00726 HME7025_00726 820671 821558 - hypothetical protein gene gene-HME7025_00726 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00726 HME7025_00727 HME7025_00727 HME7025_00727 821712 822437 + UPF0721 transmembrane protein Cell membrane%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0721 family gene gene-HME7025_00727 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00727 HME7025_00728 HME7025_00728 HME7025_00728 822927 823805 + putative oxidoreductase YcsN NADP%3B Oxidoreductase.%3B Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: vfi:VF_A0411 null%3B With NAD(+) or NADP(+) as acceptor gene gene-HME7025_00728 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00728 HME7025_00729 HME7025_00729 HME7025_00729 823863 825074 + Alkylglycerol monooxygenase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Oxidoreductase%3B Steroid biosynthesis%3B Steroid metabolism%3B Sterol biosynthesis%3B Sterol metabolism%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the sterol desaturase family%3B KEGG: gtt:GUITHDRAFT_85861 alkylglycerol monooxygenase gene gene-HME7025_00729 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00729 HME7025_00730 HME7025_00730 nudF nudF 825171 825746 + ADP-ribose diphosphatase Hydrolase%3B Magnesium.%3B Catalyzes the hydrolysis of GDP-mannose%3B Belongs to the Nudix hydrolase family. NudK subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: bur:Bcep18194_A4044 ADP-ribose pyrophosphatase gene gene-HME7025_00730 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00730 HME7025_00731 HME7025_00731 HME7025_00731 825854 827077 + Putative L%2CD-transpeptidase Cell shape%3B Cell wall biogenesis/degradation%3B Glycosyltransferase%3B Hydrolase%3B Membrane%3B Peptidoglycan synthesis%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the YkuD family gene gene-HME7025_00731 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00731 HME7025_00732 HME7025_00732 HME7025_00732 827245 828678 - hypothetical protein gene gene-HME7025_00732 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00732 HME7025_00733 HME7025_00733 HME7025_00733 828850 830139 - uncharacterized protein Signal. gene gene-HME7025_00733 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00733 HME7025_00734 HME7025_00734 HME7025_00734 830304 831167 + putative sodium/metabolite cotransporter BASS1%2C chloroplastic Chloroplast%3B Membrane%3B Plastid%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B May function as sodium-coupled metabolite transporter across the chloroplast envelope%3B Belongs to the bile acid:sodium symporter (BASS) (TC 2. A. 28) family gene gene-HME7025_00734 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00734 HME7025_00735 HME7025_00735 HME7025_00735 831273 832631 + Autocrine proliferation repressor protein Cell cycle%3B Glycoprotein%3B Secreted%3B Signal.%3B Inhibitor that slows proliferation of secreting cells (also known as chalone). May function by binding to cell surface receptors. Requires cfaD for activity. Overexpression slows proliferation%3B Belongs to the pqaA family gene gene-HME7025_00735 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00735 HME7025_00736 HME7025_00736 HME7025_00736 832700 833863 - hypothetical protein gene gene-HME7025_00736 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00736 HME7025_00737 HME7025_00737 HME7025_00737 833866 834699 - D-psicose 3-epimerase Isomerase.%3B Belongs to the hyi family%3B KEGG: hoe:IMCC20628_03197 D-psicose/D-tagatose/L-ribulose 3-epimerase gene gene-HME7025_00737 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00737 HME7025_00738 HME7025_00738 HME7025_00738 834730 835617 - hypothetical protein gene gene-HME7025_00738 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00738 HME7025_00739 HME7025_00739 HME7025_00739 835738 836775 + hypothetical protein gene gene-HME7025_00739 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00739 HME7025_00740 HME7025_00740 HME7025_00740 836809 838761 - hypothetical protein gene gene-HME7025_00740 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00740 HME7025_00741 HME7025_00741 HME7025_00741 838780 840603 - hypothetical protein gene gene-HME7025_00741 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00741 HME7025_00742 HME7025_00742 HME7025_00742 840656 840982 - Pectin degradation protein KdgF gene gene-HME7025_00742 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00742 HME7025_00743 HME7025_00743 HME7025_00743 841009 841662 - hypothetical protein gene gene-HME7025_00743 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00743 HME7025_00744 HME7025_00744 HME7025_00744 841773 842807 - Pantothenate precursors transporter PanS Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Transports ketopantoate%2C pantoate and%2C to a lesser extent%2C pantothenate into the cell. Can also transport a product of coenzyme A (CoA) degradation that serves as a precursor to CoA and enters the biosynthetic pathway between PanC and CoaBC%3B Belongs to the bile acid:sodium symporter (BASS) (TC 2. A. 28) family gene gene-HME7025_00744 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00744 HME7025_00745 HME7025_00745 HME7025_00745 842956 844560 + Beta-N-acetylhexosaminidase Cell outer membrane%3B Glycosidase%3B Hydrolase%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal.%3B Belongs to the glycosyl hydrolase 20 family%3B KEGG: bxy:BXY_34510 hexosaminidase gene gene-HME7025_00745 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00745 HME7025_00746 HME7025_00746 HME7025_00746 844687 847530 - N-acetylglucosamine-6-sulfatase Alternative splicing%3B Calcium%3B Disease mutation%3B Disulfide bond%3B Glycoprotein%3B Hydrolase%3B Ichthyosis%3B Leukodystrophy%3B Lysosome%3B Metachromatic leukodystrophy%3B Metal-binding%3B Polymorphism%3B Signal.%3B Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family%3B KEGG: rba:RB973 N-acetylglucosamine-6-sulfatase gene gene-HME7025_00746 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00746 HME7025_00747 HME7025_00747 HME7025_00747 847694 848776 - hypothetical protein gene gene-HME7025_00747 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00747 HME7025_00748 HME7025_00748 HME7025_00748 848777 849328 - hypothetical protein gene gene-HME7025_00748 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00748 HME7025_00749 HME7025_00749 HME7025_00749 849336 850271 - hypothetical protein gene gene-HME7025_00749 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00749 HME7025_00750 HME7025_00750 petC petC 850284 850745 - Plastoquinol--plastocyanin reductase KEGG: sli:Slin_4885 cytochrome b6-f complex iron-sulfur subunit gene gene-HME7025_00750 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00750 HME7025_00751 HME7025_00751 HME7025_00751 850835 851269 - Plastoquinol--plastocyanin reductase KEGG: sli:Slin_4885 cytochrome b6-f complex iron-sulfur subunit gene gene-HME7025_00751 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00751 HME7025_00752 HME7025_00752 HME7025_00752 851528 852667 + Sulfatase-modifying factor Calcium%3B Disulfide bond%3B Endoplasmic reticulum%3B Glycoprotein%3B Metal-binding%3B Oxidoreductase%3B Signal.%3B Using molecular oxygen and an unidentified reducing agent%2C oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue%2C which is also called C(alpha)-formylglycine. Known substrates include GALNS%2C ARSA%2C STS and ARSE (By similarity)%3B Belongs to the sulfatase-modifying factor family gene gene-HME7025_00752 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00752 HME7025_00753 HME7025_00753 HME7025_00753 852660 855104 - hypothetical protein gene gene-HME7025_00753 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00753 HME7025_00754 HME7025_00754 HME7025_00754 855356 857803 - hypothetical protein gene gene-HME7025_00754 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00754 HME7025_00755 HME7025_00755 HME7025_00755 858137 859549 - Quinoprotein glucose dehydrogenase (PQQ%2C quinone) Oxidoreductase%3B PQQ.%3B Belongs to the PQQ oxidoreductase GdhB family%3B KEGG: hma:pNG7073 quinoprotein glucose dehydrogenase gene gene-HME7025_00755 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00755 HME7025_00756 HME7025_00756 HME7025_00756 859696 860673 + hypothetical protein gene gene-HME7025_00756 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00756 HME7025_00757 HME7025_00757 HME7025_00757 860695 863013 + hypothetical protein gene gene-HME7025_00757 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00757 HME7025_00758 HME7025_00758 HME7025_00758 863026 864480 + hypothetical protein gene gene-HME7025_00758 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00758 HME7025_00759 HME7025_00759 HME7025_00759 864486 866669 + hypothetical protein gene gene-HME7025_00759 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00759 HME7025_00760 HME7025_00760 cefD cefD 866691 867998 + Isopenicillin-N epimerase Antibiotic biosynthesis%3B Isomerase%3B Pyridoxal phosphate.%3B Catalyzes the reversible isomerization between isopenicillin N and penicillin N. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: pbs:Plabr_2872 isopenicillin-N epimerase gene gene-HME7025_00760 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00760 HME7025_00761 HME7025_00761 HME7025_00761 868079 869212 + Heparan-alpha-glucosaminide N-acetyltransferase Acyltransferase%3B Alternative initiation%3B Disulfide bond%3B Glycoprotein%3B Lysosome%3B Membrane%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate%2C converting it into a substrate for luminal alpha-N-acetyl glucosaminidase%3B KEGG: mmu:52120 heparan-alpha-glucosaminide N-acetyltransferase gene gene-HME7025_00761 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00761 HME7025_00762 HME7025_00762 HME7025_00762 869332 870567 + hypothetical protein gene gene-HME7025_00762 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00762 HME7025_00763 HME7025_00763 HME7025_00763 870645 871742 + hypothetical protein gene gene-HME7025_00763 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00763 HME7025_00764 HME7025_00764 HME7025_00764 871739 874468 - hypothetical protein gene gene-HME7025_00764 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00764 HME7025_00765 HME7025_00765 HME7025_00765 874606 875433 + Metalloendopeptidase OMA1%2C mitochondrial Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Mitochondrion%3B Mitochondrion inner membrane%3B Protease%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Zinc.%3B Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential%2C mediates cleavage of opa1 at S1 position%2C leading to opa1 inactivation and negative regulation of mitochondrial fusion%3B Belongs to the peptidase M48 family gene gene-HME7025_00765 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00765 HME7025_00766 HME7025_00766 HME7025_00766 875529 876260 + hypothetical protein gene gene-HME7025_00766 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00766 HME7025_00767 HME7025_00767 HME7025_00767 876328 877494 + hypothetical protein gene gene-HME7025_00767 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00767 HME7025_00768 HME7025_00768 HME7025_00768 877517 878584 + hypothetical protein gene gene-HME7025_00768 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00768 HME7025_00769 HME7025_00769 HME7025_00769 878845 879825 - hypothetical protein gene gene-HME7025_00769 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00769 HME7025_00770 HME7025_00770 HME7025_00770 879835 880368 - hypothetical protein gene gene-HME7025_00770 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00770 HME7025_00771 HME7025_00771 HME7025_00771 881184 882083 - hypothetical protein gene gene-HME7025_00771 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00771 HME7025_00772 HME7025_00772 HME7025_00772 882174 888581 - Mucin-22 Membrane%3B Polymorphism%3B Repeat%3B Signal%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_00772 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00772 HME7025_00773 HME7025_00773 HME7025_00773 889324 892734 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_00773 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00773 HME7025_00774 HME7025_00774 HME7025_00774 892734 894395 + hypothetical protein gene gene-HME7025_00774 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00774 HME7025_00775 HME7025_00775 HME7025_00775 894426 895775 + Autocrine proliferation repressor protein Cell cycle%3B Glycoprotein%3B Secreted%3B Signal.%3B Inhibitor that slows proliferation of secreting cells (also known as chalone). May function by binding to cell surface receptors. Requires cfaD for activity. Overexpression slows proliferation%3B Belongs to the pqaA family gene gene-HME7025_00775 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00775 HME7025_00776 HME7025_00776 HME7025_00776 895829 896866 - hypothetical protein gene gene-HME7025_00776 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00776 HME7025_00777 HME7025_00777 HME7025_00777 896939 898750 + hypothetical protein gene gene-HME7025_00777 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00777 HME7025_00778 HME7025_00778 HME7025_00778 898747 899631 - hypothetical protein gene gene-HME7025_00778 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00778 HME7025_00779 HME7025_00779 HME7025_00779 899767 901485 - Gluconate 2-dehydrogenase (acceptor) Cell membrane%3B FAD%3B Flavoprotein%3B Membrane%3B Oxidoreductase.%3B Catalytic subunit of fructose dehydrogenase%2C an enzyme that catalyzes the oxidation of D-fructose to produce 5-keto-D- fructose%3B Belongs to the GMC oxidoreductase family%3B KEGG: htu:Htur_1314 gluconate 2-dehydrogenase alpha chain gene gene-HME7025_00779 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00779 HME7025_00780 HME7025_00780 HME7025_00780 901504 902007 - hypothetical protein gene gene-HME7025_00780 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00780 HME7025_00781 HME7025_00781 HME7025_00781 902110 903336 - uncharacterized protein To H. influenzae HI_0933 gene gene-HME7025_00781 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00781 HME7025_00782 HME7025_00782 HME7025_00782 903397 904023 - Protein MgtC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Virulence.%3B Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity)%3B Belongs to the MgtC/SapB family gene gene-HME7025_00782 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00782 HME7025_00783 HME7025_00783 HME7025_00783 904336 904761 + hypothetical protein gene gene-HME7025_00783 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00783 HME7025_00784 HME7025_00784 HME7025_00784 904859 907510 - Quinoprotein glucose dehydrogenase (PQQ%2C quinone) KEGG: rba:RB1988 quinoprotein glucose dehydrogenase gene gene-HME7025_00784 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00784 HME7025_00785 HME7025_00785 HME7025_00785 908043 909227 + hypothetical protein gene gene-HME7025_00785 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00785 HME7025_00786 HME7025_00786 HME7025_00786 911099 912043 + L-galactose dehydrogenase Carbohydrate metabolism%3B Galactose metabolism%3B NAD%3B Oxidoreductase.%3B Catalyzes the oxidation of L-galactose to L-galactono- 1%2C4-lactone in the presence of NAD(+). Uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+)%3B Belongs to the aldo/keto reductase family%3B Contains 1 SIS domain gene gene-HME7025_00786 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00786 HME7025_00787 HME7025_00787 sorD sorD 912058 913077 + L-iditol 2-dehydrogenase Metal-binding%3B NADP%3B Oxidoreductase%3B Zinc.%3B Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA%3B Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: lmo:lmo2663 L-iditol 2-dehydrogenase gene gene-HME7025_00787 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00787 HME7025_00788 HME7025_00788 HME7025_00788 913079 913894 + D-psicose 3-epimerase Belongs to the hyi family%3B KEGG: mmt:Metme_2524 D-psicose/D-tagatose/L-ribulose 3-epimerase gene gene-HME7025_00788 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00788 HME7025_00789 HME7025_00789 rhaM rhaM 913906 914241 + L-rhamnose mutarotase Isomerase.%3B Plays a role in the catabolism of L-fucose. Involved in the anomeric conversion of L-fucose%3B Belongs to the RbsD / FucU family. FucU mutarotase subfamily%3B KEGG: hhy:Halhy_4140 L-rhamnose mutarotase gene gene-HME7025_00789 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00789 HME7025_00790 HME7025_00790 HME7025_00790 914274 915308 - hypothetical protein gene gene-HME7025_00790 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00790 HME7025_00791 HME7025_00791 HME7025_00791 915339 916448 - Inositol 2-dehydrogenase NADP%3B Oxidoreductase.%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: soc:105192997 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_00791 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00791 HME7025_00792 HME7025_00792 HME7025_00792 916607 917464 + Glycerophosphodiester phosphodiesterase Cytoplasm%3B Glycoprotein%3B Hydrolase%3B Magnesium%3B Membrane%3B Metal-binding%3B Transmembrane%3B Transmembrane helix.%3B Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity)%3B Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Contains 1 GP-PDE domain%3B KEGG: nko:Niako_7128 glycerophosphoryl diester phosphodiesterase gene gene-HME7025_00792 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00792 HME7025_00793 HME7025_00793 gcaT gcaT 917684 918871 - Glycine C-acetyltransferase Acyltransferase%3B Pyridoxal phosphate%3B Transferase.%3B Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: mmw:Mmwyl1_3792 glycine C-acetyltransferase gene gene-HME7025_00793 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00793 HME7025_00794 HME7025_00794 HME7025_00794 918885 919829 - L-threonine 3-dehydrogenase Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: acan:ACA1_396200 threonine 3-dehydrogenase gene gene-HME7025_00794 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00794 HME7025_00795 HME7025_00795 HME7025_00795 919968 920075 - hypothetical protein gene gene-HME7025_00795 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00795 HME7025_00796 HME7025_00796 fucA fucA 920216 920734 + Alpha-L-fucosidase KEGG: fgi:OP10G_2626 alpha-L-fucosidase gene gene-HME7025_00796 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00796 HME7025_00797 HME7025_00797 HME7025_00797 920801 921790 - Pyridoxine 4-dehydrogenase Auxin signaling pathway%3B NADP%3B Oxidoreductase.%3B Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: bur:Bcep18194_B2855 pyridoxine 4-dehydrogenase gene gene-HME7025_00797 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00797 HME7025_00798 HME7025_00798 HME7025_00798 921808 922707 - HTH-type transcriptional activator RhaS Activator%3B Cytoplasm%3B DNA-binding%3B Repeat%3B Rhamnose metabolism%3B Transcription%3B Transcription regulation.%3B Activates expression of the rhaBAD and rhaT operons%3B Contains 2 HTH araC/xylS-type DNA-binding domains gene gene-HME7025_00798 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00798 HME7025_00799 HME7025_00799 HME7025_00799 922719 923555 - hypothetical protein gene gene-HME7025_00799 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00799 HME7025_00800 HME7025_00800 HME7025_00800 923794 924618 + hypothetical protein gene gene-HME7025_00800 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00800 HME7025_00801 HME7025_00801 HME7025_00801 924640 925197 - Protein VdlD Hydrolase.%3B Belongs to the acyl coenzyme A hydrolase family%3B Contains 1 HotDog ACOT-type domain%3B KEGG: oaa:100080743 acyl-CoA thioesteraes 11%3B Thiolester hydrolases gene gene-HME7025_00801 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00801 HME7025_00802 HME7025_00802 cobA cobA 925201 925959 - Uroporphyrinogen-III C-methyltransferase Chloroplast%3B Cobalamin biosynthesis%3B Methyltransferase%3B Plastid%3B Porphyrin biosynthesis%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-%3B their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin%3B Belongs to the precorrin methyltransferase family%3B KEGG: sxl:SXYLSMQ121_0532 uroporphyrin-III C-methyltransferase gene gene-HME7025_00802 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00802 HME7025_00803 HME7025_00803 nirB nirB 926410 928905 + Nitrite reductase (NADH) Aromatic hydrocarbons catabolism%3B Electron transport%3B FAD%3B Flavoprotein%3B NAD%3B Oxidoreductase%3B Plasmid%3B Transport.%3B Ferredoxin reductase component of the biphenyl dioxygenase system that catalyzes the stereospecific dihydroxylation of the aromatic ring of biphenyl%2C yielding a dihydrodiol compound. Is likely involved in biphenyl degradation that allows growth of Rhodococcus sp. strain RHA1 on biphenyl as the sole source of carbon and energy. The dioxygenase system can also use naphtalene and 4-chlorobiphenyl (4-CB) as substrates%2C as well as some polychlorinated biphenyls (PCB) such as 2%2C2'- dichlorobiphenyl%2C 2%2C3-dichlorobiphenyl and 2%2C5%2C2'- trichlorobiphenyl. It exhibits weak activity toward dibenzofuran and dibenzo-p-dioxin. Electrons are transferred from NADH to the [2Fe-2S] cluster in BphA1 via FAD of BphA4 and [2Fe-2S] cluster of BphA3%3B Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family%3B KEGG: dji:CH75_04015 nitrite reductase (NADH) large subunit gene gene-HME7025_00803 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00803 HME7025_00804 HME7025_00804 nirD nirD 928926 929282 + Nitrite reductase (NADH) Cytoplasm%3B NAD%3B Nitrate assimilation%3B Oxidoreductase.%3B Required for activity of the reductase%3B To B. subtilis NasE%3B KEGG: dfe:Dfer_2057 nitrite reductase (NADH) small subunit gene gene-HME7025_00804 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00804 HME7025_00805 HME7025_00805 HME7025_00805 929305 930765 + hypothetical protein gene gene-HME7025_00805 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00805 HME7025_00806 HME7025_00806 HME7025_00806 930786 932066 + High-affinity nitrate transporter Cell membrane%3B Membrane%3B Nitrate assimilation%3B Phosphoprotein%3B Transmembrane%3B Transmembrane helix.%3B Involved in nitrate transport%2C but does not seem to be able to mediate transport by its own. Acts as a dual component transporter with NTR3. 1. Acts as a repressor of lateral root initiation under high sucrose/low nitrate conditions%3B Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2. A. 1. 8) family gene gene-HME7025_00806 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00806 HME7025_00807 HME7025_00807 nasA nasA 932085 935624 + Nitrate reductase 4Fe-4S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Molybdenum%3B Nitrate assimilation%3B Oxidoreductase%3B Secreted%3B Signal%3B Transport.%3B Catalytic subunit of the nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC. Essential function for nitrate assimilation and may have a role in anaerobic metabolism%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: spe:Spro_2905 assimilatory nitrate reductase catalytic subunit gene gene-HME7025_00807 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00807 HME7025_00808 HME7025_00808 HME7025_00808 935605 936108 + hypothetical protein gene gene-HME7025_00808 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00808 HME7025_00809 HME7025_00809 HME7025_00809 936105 937535 + Rubredoxin Electron transport%3B Iron%3B Metal-binding%3B Transport.%3B Rubredoxin is a small nonheme%2C iron protein lacking acid-labile sulfide. Its single Fe%2C chelated to 4 Cys%2C functions as an electron acceptor and may also stabilize the conformation of the molecule. Belongs to the rubredoxin family%3B Contains 1 rubredoxin-like domain gene gene-HME7025_00809 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00809 HME7025_00810 HME7025_00810 mobA mobA 937528 938109 - Molybdenum cofactor guanylyltransferase KEGG: dja:HY57_15905 molybdopterin-guanine dinucleotide biosynthesis protein A gene gene-HME7025_00810 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00810 HME7025_00811 HME7025_00811 HME7025_00811 938106 938381 - hypothetical protein gene gene-HME7025_00811 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00811 HME7025_00812 HME7025_00812 HME7025_00812 938497 939393 + hypothetical protein gene gene-HME7025_00812 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00812 HME7025_00813 HME7025_00813 HME7025_00813 939678 940235 + hypothetical protein gene gene-HME7025_00813 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00813 HME7025_00814 HME7025_00814 HME7025_00814 940240 941292 + hypothetical protein gene gene-HME7025_00814 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00814 HME7025_00815 HME7025_00815 HME7025_00815 941359 943935 - hypothetical protein gene gene-HME7025_00815 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00815 HME7025_00816 HME7025_00816 HME7025_00816 944160 945560 - Extracellular protease Disulfide bond%3B Hydrolase%3B Protease%3B Secreted%3B Serine protease%3B Signal%3B Zymogen.%3B Belongs to the peptidase S8 family%3B Contains 1 peptidase S8 domain%3B KEGG: din:Selin_1585 serine protease%3B Serine endopeptidases gene gene-HME7025_00816 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00816 HME7025_00817 HME7025_00817 HME7025_00817 945949 947274 - hypothetical protein gene gene-HME7025_00817 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00817 HME7025_00818 HME7025_00818 HME7025_00818 947437 947535 + hypothetical protein gene gene-HME7025_00818 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00818 HME7025_00819 HME7025_00819 HME7025_00819 947747 948184 + hypothetical protein gene gene-HME7025_00819 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00819 HME7025_00820 HME7025_00820 HME7025_00820 948414 948707 + hypothetical protein gene gene-HME7025_00820 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00820 HME7025_00821 HME7025_00821 phrB phrB 948704 949789 + Deoxyribodipyrimidine photo-lyase ATP-binding%3B Chromophore%3B Cytoplasm%3B Disulfide bond%3B FAD%3B Flavoprotein%3B Nucleotide-binding%3B Nucleus%3B Phosphoprotein%3B Photoreceptor protein%3B Receptor%3B Sensory transduction.%3B Mediates blue light-induced gene expression through the inhibition of COP1-mediated degradation of the transcription factor BIT1. Involved in blue light-dependent stomatal opening%2C CHS gene expression%2C inhibition of stem growth and increase of root growth%3B Belongs to the DNA photolyase class-1 family%3B Contains 1 photolyase/cryptochrome alpha/beta domain%3B KEGG: syc:syc2227_c deoxyribodipyrimidine photo-lyase gene gene-HME7025_00821 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00821 HME7025_00822 HME7025_00822 HME7025_00822 949737 951233 - (6-4) photolyase 4Fe-4S%3B Chromophore%3B DNA damage%3B DNA repair%3B DNA-binding%3B FAD%3B Flavoprotein%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B Nucleotide-binding.%3B Photolyase involved in the repair of UV-induced (6-4) lesions in DNA. Catalyzes the photoreactivation of (6-4) pyrimidine-pyrimidone photoproducts by using blue-light energy. Can repair (6-4) photoproducts in ssDNA as well as in dsDNA%3B Belongs to the iron-sulfur bacterial cryptochrome/photolyase (FeS-BCP) family gene gene-HME7025_00822 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00822 HME7025_00823 HME7025_00823 HME7025_00823 951434 952471 - Endo-1%2C4-beta-xylanase Carbohydrate metabolism%3B Glycosidase%3B Hydrolase%3B Polysaccharide degradation%3B Repeat%3B Signal%3B Xylan degradation.%3B Endoxylanase with high hydrolytic activity on birchwood and oat spelt xylan. Xylotetraose%2C xylotriose%2C xylobiose and xylose are the main products from birchwood xylan hydrolysis. Shows increasing activity on xylo-oligosaccharides of increasing length. Displays very low hydrolytic activity on Avicel%2C carboxymethylcellulose (CMC) and p-nitrophenyl-beta- xylopyranoside. Also shows transxylosidase activity%2C allowing the formation of xylo-oligosaccharides of higher degreee of polymerization than the starting substrate%3B Belongs to the glycosyl hydrolase 10 (cellulase F) family%3B Contains 2 CBM-cenC (cenC-type cellulose-binding) domains%3B Contains 1 GH10 (glycosyl hydrolase family 10) domain%3B KEGG: nko:Niako_2414 endo-1%2C4-beta-xylanase gene gene-HME7025_00823 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00823 HME7025_00824 HME7025_00824 aslA aslA 952659 954122 + Arylsulfatase Calcium%3B Cytoplasm%3B Hydrolase%3B Metal-binding%3B Nucleus.%3B Belongs to the sulfatase family%3B KEGG: wse:WALSEDRAFT_35476 arylsulfatase gene gene-HME7025_00824 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00824 HME7025_00825 HME7025_00825 HME7025_00825 954246 954320 - tRNA-Val tRNA gene-HME7025_00825 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00825 HME7025_00826 HME7025_00826 HME7025_00826 954471 955286 + UPF0053 inner membrane protein YgdQ Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0053 family gene gene-HME7025_00826 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00826 HME7025_00827 HME7025_00827 HME7025_00827 955653 956072 - Protein-disulfide reductase KEGG: dpb:BABL1_686 thiol:disulfide interchange protein DsbD gene gene-HME7025_00827 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00827 HME7025_00828 HME7025_00828 dnaN dnaN 956154 957278 - DNA-directed DNA polymerase Cytoplasm%3B DNA replication%3B DNA-directed DNA polymerase%3B Nucleotidyltransferase%3B Transferase.%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA%2C it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)%3B KEGG: bth:BT_1364 DNA polymerase III subunit beta gene gene-HME7025_00828 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00828 HME7025_00829 HME7025_00829 HME7025_00829 957373 959049 - hypothetical protein gene gene-HME7025_00829 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00829 HME7025_00830 HME7025_00830 ppiD ppiD 959123 961240 - Peptidylprolyl isomerase KEGG: phe:Phep_4026 peptidyl-prolyl cis-trans isomerase D gene gene-HME7025_00830 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00830 HME7025_00831 HME7025_00831 argD argD 961363 962487 - Acetylornithine transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Arginine biosynthesis%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase.%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily%3B KEGG: bth:BT_3758 acetylornithine aminotransferase gene gene-HME7025_00831 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00831 HME7025_00832 HME7025_00832 argC argC 962529 963479 - N-acetyl-gamma-glutamyl-phosphate reductase Amino-acid biosynthesis%3B Arginine biosynthesis%3B Cytoplasm%3B NADP%3B Oxidoreductase.%3B Belongs to the NAGSA dehydrogenase family. Type 1 subfamily%3B KEGG: pae:PA0662 N-acetyl-gamma-glutamyl-phosphate reductase gene gene-HME7025_00832 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00832 HME7025_00833 HME7025_00833 argG argG 963481 964674 - Argininosuccinate synthase Amino-acid biosynthesis%3B Arginine biosynthesis%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding.%3B Belongs to the argininosuccinate synthase family. Type 1 subfamily%3B KEGG: dfe:Dfer_4424 argininosuccinate synthase gene gene-HME7025_00833 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00833 HME7025_00834 HME7025_00834 HME7025_00834 964677 965342 - Argininosuccinate synthase KEGG: bbl:BLBBGE_313 argininosuccinate synthase gene gene-HME7025_00834 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00834 HME7025_00835 HME7025_00835 HME7025_00835 965567 966178 + Leucyltransferase Acyltransferase%3B Cytoplasm%3B Transferase.%3B Functions in the N-end rule pathway of protein degradation where it conjugates Leu%2C Phe and%2C less efficiently%2C Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine%3B Belongs to the L/F-transferase family%3B KEGG: hau:Haur_3202 leucyl/phenylalanyl-tRNA--protein transferase gene gene-HME7025_00835 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00835 HME7025_00836 HME7025_00836 HME7025_00836 966198 966638 - Hydroxylaminobenzene mutase HabB Cell membrane%3B Isomerase%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the rearrangement of hydroxylaminobenzene to 2-aminophenol%3B KEGG: ial:IALB_0051 hydroxylaminobenzene mutase%3B Transferring hydroxy groups gene gene-HME7025_00836 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00836 HME7025_00837 HME7025_00837 proB proB 966802 967830 + Glutamate 5-kinase Amino-acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Proline biosynthesis%3B Transferase.%3B Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate%3B Belongs to the glutamate 5-kinase family%3B KEGG: cpi:Cpin_6815 glutamate 5-kinase gene gene-HME7025_00837 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00837 HME7025_00838 HME7025_00838 HME7025_00838 967839 968456 - hypothetical protein gene gene-HME7025_00838 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00838 HME7025_00839 HME7025_00839 HME7025_00839 968488 968787 - hypothetical protein gene gene-HME7025_00839 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00839 HME7025_00840 HME7025_00840 HME7025_00840 968793 969188 - hypothetical protein gene gene-HME7025_00840 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00840 HME7025_00841 HME7025_00841 HME7025_00841 969272 969889 - Transmembrane protein Coiled coil%3B Glycoprotein%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_00841 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00841 HME7025_00842 HME7025_00842 HME7025_00842 969981 971504 - hypothetical protein gene gene-HME7025_00842 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00842 HME7025_00843 HME7025_00843 HME7025_00843 971739 972296 - hypothetical protein gene gene-HME7025_00843 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00843 HME7025_00844 HME7025_00844 HME7025_00844 972458 975820 - Protein translocase subunit SecA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B Membrane%3B Metal-binding%3B Nucleotide-binding%3B Protein transport%3B Translocation%3B Transport%3B Zinc.%3B Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene-HME7025_00844 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00844 HME7025_00845 HME7025_00845 HME7025_00845 975954 976589 - hypothetical protein gene gene-HME7025_00845 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00845 HME7025_00846 HME7025_00846 HME7025_00846 976712 978082 + hypothetical protein gene gene-HME7025_00846 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00846 HME7025_00847 HME7025_00847 HME7025_00847 978085 979614 + hypothetical protein gene gene-HME7025_00847 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00847 HME7025_00848 HME7025_00848 HME7025_00848 979721 980650 + hypothetical protein gene gene-HME7025_00848 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00848 HME7025_00849 HME7025_00849 HME7025_00849 980629 981381 + hypothetical protein gene gene-HME7025_00849 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00849 HME7025_00850 HME7025_00850 uppS uppS 981462 982211 + Ditrans%2Cpolycis-undecaprenyl-diphosphate synthase ((2E%2C6E)-farnesyl-diphosphate specific) Magnesium%3B Metal-binding%3B Transferase.%3B Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids%3B Belongs to the UPP synthase family%3B KEGG: sdt:SPSE_1522 undecaprenyl diphosphate synthase gene gene-HME7025_00850 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00850 HME7025_00851 HME7025_00851 HME7025_00851 982220 984901 + Keratin%2C type II cytoskeletal Cell membrane%3B Citrullination%3B Coiled coil%3B Disease mutation%3B Ichthyosis%3B Intermediate filament%3B Keratin%3B Membrane%3B Methylation%3B Palmoplantar keratoderma%3B Phosphoprotein%3B Polymorphism.%3B May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK%3B Belongs to the intermediate filament family gene gene-HME7025_00851 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00851 HME7025_00852 HME7025_00852 HME7025_00852 984949 985494 + hypothetical protein gene gene-HME7025_00852 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00852 HME7025_00853 HME7025_00853 HME7025_00853 985514 986116 + hypothetical protein gene gene-HME7025_00853 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00853 HME7025_00854 HME7025_00854 HME7025_00854 986380 987714 - RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Nucleus%3B Phosphoprotein%3B Ribosome biogenesis%3B RNA-binding%3B rRNA processing.%3B ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0%2C A1%2C and A2%2C leading to mature 18S rRNA%3B Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: tdn:Suden_0610 ATP-dependent RNA helicase RhlE gene gene-HME7025_00854 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00854 HME7025_00855 HME7025_00855 HME7025_00855 987804 988280 - Nutrient stress-induced DNA-binding protein DNA-binding%3B Heme%3B Iron%3B Metal-binding.%3B Involved in protection of chromosomal DNA from damage under nutrient-limited and oxidative stress conditions. Binds heme (By similarity)%3B Belongs to the Dps family gene gene-HME7025_00855 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00855 HME7025_00856 HME7025_00856 HME7025_00856 988445 989173 - hypothetical protein gene gene-HME7025_00856 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00856 HME7025_00857 HME7025_00857 lspA lspA 989204 989854 - Signal peptidase II Aspartyl protease%3B Cell membrane%3B Hydrolase%3B Membrane%3B Protease%3B Transmembrane%3B Transmembrane helix.%3B This protein specifically catalyzes the removal of signal peptides from prolipoproteins%3B Belongs to the peptidase A8 family%3B KEGG: hsw:Hsw_4239 signal peptidase II gene gene-HME7025_00857 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00857 HME7025_00858 HME7025_00858 HME7025_00858 989851 991050 - Carbapenem antibiotics biosynthesis protein CarD Antibiotic biosynthesis%3B Oxidoreductase.%3B Belongs to the proline oxidase family%3B KEGG: pko:PKOR_02040 proline dehydrogenase%3B Acting on the CH-NH group of donors gene gene-HME7025_00858 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00858 HME7025_00859 HME7025_00859 HME7025_00859 991164 992258 + Chorismate mutase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Transferase.%3B Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). Belongs to the class-I DAHP synthase family%3B KEGG: eol:Emtol_3294 chorismate mutase gene gene-HME7025_00859 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00859 HME7025_00860 HME7025_00860 HME7025_00860 992357 993253 - hypothetical protein gene gene-HME7025_00860 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00860 HME7025_00861 HME7025_00861 ridA ridA 993330 993701 + 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: dsf:UWK_01305 2-iminobutanoate/2-iminopropanoate deaminase gene gene-HME7025_00861 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00861 HME7025_00862 HME7025_00862 earS earS 993708 995210 + Glutamate--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: shi:Shel_09840 glutamyl-tRNA synthetase gene gene-HME7025_00862 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00862 HME7025_00863 HME7025_00863 HME7025_00863 995212 995403 + hypothetical protein gene gene-HME7025_00863 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00863 HME7025_00864 HME7025_00864 gatC gatC 995390 995677 + Asparaginyl-tRNA synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)%3B Belongs to the GatC family%3B KEGG: pae:PA4482 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C gene gene-HME7025_00864 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00864 HME7025_00865 HME7025_00865 aroB aroB 995678 996706 - 3-dehydroquinate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Kinase%3B Lyase%3B Metal-binding%3B Multifunctional enzyme%3B NADP%3B Nucleotide-binding%3B Oxidoreductase%3B Transferase%3B Zinc.%3B The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis%3B In the N-terminal sectio%3B belongs to the dehydroquinate synthase family%3B In the 2nd sectio%3B belongs to the EPSP synthase family%3B In the 3rd sectio%3B belongs to the shikimate kinase family%3B In the 4th sectio%3B belongs to the type-I 3- dehydroquinase family%3B In the C-terminal sectio%3B belongs to the shikimate dehydrogenase family%3B KEGG: lby:Lbys_1928 3-dehydroquinate synthase gene gene-HME7025_00865 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00865 HME7025_00866 HME7025_00866 HME7025_00866 996651 996833 - hypothetical protein gene gene-HME7025_00866 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00866 HME7025_00867 HME7025_00867 pdhB pdhB 996849 997832 + Pyruvate dehydrogenase (acetyl-transferring) Glycolysis%3B Lipoyl%3B Oxidoreductase%3B Pyruvate%3B Thiamine pyrophosphate.%3B The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Contains 1 lipoyl-binding domain%3B KEGG: gsu:GSU2436 pyruvate dehydrogenase E1 component beta subunit gene gene-HME7025_00867 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00867 HME7025_00868 HME7025_00868 degP degP 998077 999552 - Peptidase Do Hydrolase%3B Periplasm%3B Protease%3B Repeat%3B Serine protease%3B Signal%3B Stress response.%3B Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions%3B Belongs to the peptidase S1C family%3B Contains 2 PDZ (DHR) domains%3B KEGG: mop:Mesop_4318 serine protease Do gene gene-HME7025_00868 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00868 HME7025_00869 HME7025_00869 karS karS 999891 1001606 + Lysine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis.%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: afd:Alfi_1747 lysyl-tRNA synthetase%2C class II gene gene-HME7025_00869 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00869 HME7025_00870 HME7025_00870 HME7025_00870 1001756 1001950 - Cold shock-like protein CspA Activator%3B Cytoplasm%3B DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 CSD (cold-shock) domain gene gene-HME7025_00870 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00870 HME7025_00871 HME7025_00871 HME7025_00871 1002273 1002494 + hypothetical protein gene gene-HME7025_00871 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00871 HME7025_00872 HME7025_00872 HME7025_00872 1002491 1003498 - hypothetical protein gene gene-HME7025_00872 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00872 HME7025_00873 HME7025_00873 HME7025_00873 1003602 1005314 + Cationic amino acid transporter 9%2C chloroplastic Amino-acid transport%3B Chloroplast%3B Membrane%3B Plastid%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Permease involved in the transport of the cationic amino acids%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2. A. 3. 3) family gene gene-HME7025_00873 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00873 HME7025_00874 HME7025_00874 HME7025_00874 1005341 1006033 - Putative membrane protease YugP Cell membrane%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Zinc. gene gene-HME7025_00874 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00874 HME7025_00875 HME7025_00875 gmhC gmhC 1006039 1006521 - D-glycero-beta-D-manno-heptose-7-phosphate kinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1%2C7-bisphosphate%3B Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate%2C yielding ADP-D-glycero-beta-D-manno- heptose%3B In the N-terminal sectio%3B belongs to the carbohydrate kinase PfkB family%3B In the C-terminal sectio%3B belongs to the cytidylyltransferase family%3B KEGG: mbat:BN1208_1047 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase gene gene-HME7025_00875 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00875 HME7025_00876 HME7025_00876 HME7025_00876 1006505 1007500 - hypothetical protein gene gene-HME7025_00876 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00876 HME7025_00877 HME7025_00877 glgA glgA 1007634 1008443 + Starch synthase Glycogen biosynthesis%3B Glycosyltransferase%3B Transferase.%3B Synthesizes alpha-1%2C4-glucan chains using ADP-glucose%3B Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily%3B KEGG: mei:Msip34_1437 starch synthase gene gene-HME7025_00877 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00877 HME7025_00878 HME7025_00878 HME7025_00878 1008394 1009764 + hypothetical protein gene gene-HME7025_00878 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00878 HME7025_00879 HME7025_00879 HME7025_00879 1009776 1010561 + Hydrolase YafV Hydrolase.%3B Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family%3B Contains 1 CN hydrolase domain gene gene-HME7025_00879 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00879 HME7025_00880 HME7025_00880 cysA cysA 1010558 1011265 - Sulfate-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Sulfate transport%3B Transport.%3B Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3. A. 1. 6) family%3B Contains 1 ABC transporter domain%3B KEGG: eco:b2422 sulfate transport system ATP-binding protein gene gene-HME7025_00880 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00880 HME7025_00881 HME7025_00881 HME7025_00881 1011356 1012576 + 3%2C4-dihydroxy-2-butanone-4-phosphate synthase GTP-binding%3B Hydrolase%3B Lyase%3B Magnesium%3B Manganese%3B Metal-binding%3B Multifunctional enzyme%3B Nucleotide-binding%3B Riboflavin biosynthesis%3B Zinc.%3B Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3%2C4-dihydroxy-2-butanone 4-phosphate%3B Catalyzes the conversion of GTP to 2%2C5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP)%2C formate and pyrophosphate%3B In the N-terminal sectio%3B belongs to the DHBP synthase family%3B In the C-terminal sectio%3B belongs to the GTP cyclohydrolase II family%3B KEGG: cut:CUTER_05875 3%2C4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II gene gene-HME7025_00881 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00881 HME7025_00882 HME7025_00882 HME7025_00882 1012744 1012935 + hypothetical protein gene gene-HME7025_00882 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00882 HME7025_00883 HME7025_00883 HME7025_00883 1012980 1013390 + hypothetical protein gene gene-HME7025_00883 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00883 HME7025_00884 HME7025_00884 HME7025_00884 1013400 1014305 - Prohibitin-2 Acetylation%3B Coiled coil%3B Cytoplasm%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B Nucleus%3B Phosphoprotein%3B Receptor%3B Repressor%3B Transcription%3B Transcription regulation.%3B Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity)%3B Belongs to the prohibitin family gene gene-HME7025_00884 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00884 HME7025_00885 HME7025_00885 HME7025_00885 1014492 1015220 + Polar-amino-acid-transporting ATPase Amino-acid transport%3B ATP-binding%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Part of the ABC transporter complex TcyJKLMN involved in L-cystine import. Responsible for energy coupling to the transport system (Probable). Is also involved in cystathionine%2C djenkolate%2C and S-methylcysteine transport%3B Belongs to the ABC transporter superfamily. L-cystine importer (TC 3. A. 1. 3. 13) family%3B Contains 1 ABC transporter domain%3B KEGG: cama:F384_12905 polar amino acid transport system ATP-binding protein gene gene-HME7025_00885 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00885 HME7025_00886 HME7025_00886 murB murB 1015222 1016262 + UDP-N-acetylmuramate dehydrogenase Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B FAD%3B Flavoprotein%3B NADP%3B Oxidoreductase%3B Peptidoglycan synthesis.%3B Cell wall formation%3B Belongs to the MurB family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: ppr:PBPRA3446 UDP-N-acetylmuramate dehydrogenase gene gene-HME7025_00886 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00886 HME7025_00887 HME7025_00887 kdsA kdsA 1016264 1017073 + 3-deoxy-8-phosphooctulonate synthase Cytoplasm%3B Lipopolysaccharide biosynthesis%3B Transferase.%3B Belongs to the KdsA family%3B KEGG: oan:Oant_2055 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) gene gene-HME7025_00887 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00887 HME7025_00888 HME7025_00888 HME7025_00888 1017392 1019023 - hypothetical protein gene gene-HME7025_00888 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00888 HME7025_00889 HME7025_00889 HME7025_00889 1019091 1020047 - hypothetical protein gene gene-HME7025_00889 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00889 HME7025_00890 HME7025_00890 rnt1 rnt1 1020054 1020854 - Ribonuclease III Cytoplasm%3B Endonuclease%3B Hydrolase%3B Magnesium%3B Metal-binding%3B mRNA processing%3B Nuclease%3B RNA-binding%3B rRNA processing%3B rRNA-binding%3B tRNA processing.%3B Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs%2C and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism%3B Contains 1 DRBM (double-stranded RNA-binding) domain%3B Contains 1 RNase III domain%3B KEGG: sli:Slin_5150 ribonuclease III gene gene-HME7025_00890 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00890 HME7025_00891 HME7025_00891 fabF fabF 1020802 1022049 - Beta-ketoacyl-[acyl-carrier-protein] synthase II Acyltransferase%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Transferase.%3B Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis (By similarity)%3B Belongs to the beta-ketoacyl-ACP synthases family%3B KEGG: tcx:Tcr_0714 3-oxoacyl-(acyl-carrier-protein) synthase II gene gene-HME7025_00891 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00891 HME7025_00892 HME7025_00892 HME7025_00892 1022173 1022475 - Acyl carrier protein Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Phosphopantetheine%3B Phosphoprotein.%3B Carrier of the growing fatty acid chain in fatty acid biosynthesis%3B Contains 1 acyl carrier domain gene gene-HME7025_00892 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00892 HME7025_00893 HME7025_00893 HME7025_00893 1022575 1023492 - Glucokinase ATP-binding%3B Cytoplasm%3B Glycolysis%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Belongs to the ROK (NagC/XylR) family%3B KEGG: lby:Lbys_2938 glucokinase gene gene-HME7025_00893 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00893 HME7025_00894 HME7025_00894 HME7025_00894 1023570 1024025 - hypothetical protein gene gene-HME7025_00894 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00894 HME7025_00895 HME7025_00895 HME7025_00895 1024018 1024608 - Thymidine kinase ATP-binding%3B Cytoplasm%3B DNA synthesis%3B Kinase%3B Metal-binding%3B Nucleotide-binding%3B Transferase%3B Zinc.%3B Belongs to the thymidine kinase family%3B KEGG: bsm:BSM4216_3685 thymidine kinase gene gene-HME7025_00895 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00895 HME7025_00896 HME7025_00896 sdhB sdhB 1024656 1025414 - Succinate dehydrogenase (quinone) KEGG: rsi:Runsl_4725 succinate dehydrogenase / fumarate reductase%2C iron-sulfur subunit gene gene-HME7025_00896 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00896 HME7025_00897 HME7025_00897 sdhA sdhA 1025424 1027403 - Succinate dehydrogenase (quinone) Cell membrane%3B Electron transport%3B FAD%3B Flavoprotein%3B Membrane%3B Oxidoreductase%3B Transport%3B Tricarboxylic acid cycle.%3B Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily%3B KEGG: bmx:BMS_2197 succinate dehydrogenase / fumarate reductase%2C flavoprotein subunit gene gene-HME7025_00897 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00897 HME7025_00898 HME7025_00898 HME7025_00898 1027426 1028094 - hypothetical protein gene gene-HME7025_00898 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00898 HME7025_00899 HME7025_00899 HME7025_00899 1028372 1031107 + hypothetical protein gene gene-HME7025_00899 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00899 HME7025_00900 HME7025_00900 HME7025_00900 1031107 1031481 + hypothetical protein gene gene-HME7025_00900 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00900 HME7025_00901 HME7025_00901 HME7025_00901 1031462 1032559 - hypothetical protein gene gene-HME7025_00901 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00901 HME7025_00902 HME7025_00902 fabD fabD 1032660 1033541 + [Acyl-carrier-protein] S-malonyltransferase Acyltransferase%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Transferase.%3B Belongs to the FabD family%3B KEGG: psal:PSLF89_3069 (acyl-carrier-protein) S-malonyltransferase gene gene-HME7025_00902 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00902 HME7025_00903 HME7025_00903 HME7025_00903 1033676 1033749 + tRNA-Gln tRNA gene-HME7025_00903 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00903 HME7025_00904 HME7025_00904 HME7025_00904 1033902 1034369 + hypothetical protein gene gene-HME7025_00904 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00904 HME7025_00905 HME7025_00905 HME7025_00905 1034642 1036783 + hypothetical protein gene gene-HME7025_00905 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00905 HME7025_00906 HME7025_00906 HME7025_00906 1036780 1037640 - TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_00906 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00906 HME7025_00907 HME7025_00907 HME7025_00907 1037652 1038935 - Cellobiose 2-epimerase Isomerase.%3B Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man). Catalyzes epimerization but also isomerization for beta-1%2C4- and alpha-1%2C4- gluco-oligosaccharides. Can use cellobiose%2C lactose%2C cellotriose%2C maltose and maltotriose%3B Belongs to the cellobiose 2-epimerase family gene gene-HME7025_00907 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00907 HME7025_00908 HME7025_00908 HME7025_00908 1038938 1039927 - D-glycero-beta-D-manno-heptose-7-phosphate kinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1%2C7-bisphosphate%3B Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate%2C yielding ADP-D-glycero-beta-D-manno- heptose%3B In the N-terminal sectio%3B belongs to the carbohydrate kinase PfkB family%3B In the C-terminal sectio%3B belongs to the cytidylyltransferase family%3B KEGG: tdn:Suden_0580 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase gene gene-HME7025_00908 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00908 HME7025_00909 HME7025_00909 HME7025_00909 1040064 1040543 - hypothetical protein gene gene-HME7025_00909 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00909 HME7025_00910 HME7025_00910 HME7025_00910 1040568 1041026 - hypothetical protein gene gene-HME7025_00910 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00910 HME7025_00911 HME7025_00911 HME7025_00911 1041071 1042084 - hypothetical protein gene gene-HME7025_00911 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00911 HME7025_00912 HME7025_00912 HME7025_00912 1042484 1042930 - hypothetical protein gene gene-HME7025_00912 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00912 HME7025_00913 HME7025_00913 HME7025_00913 1042945 1043709 - hypothetical protein gene gene-HME7025_00913 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00913 HME7025_00914 HME7025_00914 HME7025_00914 1043964 1044377 - hypothetical protein gene gene-HME7025_00914 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00914 HME7025_00915 HME7025_00915 catC catC 1045030 1045296 - Muconolactone Delta-isomerase KEGG: rsi:Runsl_2717 muconolactone D-isomerase gene gene-HME7025_00915 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00915 HME7025_00916 HME7025_00916 nemA nemA 1045310 1046389 - 12-oxophytodienoate reductase Fatty acid biosynthesis%3B Fatty acid metabolism%3B Flavoprotein%3B FMN%3B Lipid biosynthesis%3B Lipid metabolism%3B NADP%3B Oxidoreductase%3B Oxylipin biosynthesis.%3B Probably involved in the biosynthesis or metabolism of oxylipin signaling molecules. In vitro%2C reduces cis(-)-12- oxophytodienoic acid (cis(-)-OPDA) and to cis(-)-OPC-8:0%3B Belongs to the NADH:flavin oxidoreductase/NADH oxidase family%3B KEGG: sfa:Sfla_3635 N-ethylmaleimide reductase%3B Oxidoreductases gene gene-HME7025_00916 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00916 HME7025_00917 HME7025_00917 HME7025_00917 1046509 1046841 + putative HTH-type transcriptional regulator YdeP DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH hxlR-type DNA-binding domain gene gene-HME7025_00917 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00917 HME7025_00918 HME7025_00918 manB manB 1047000 1048388 + Phosphomannomutase Cell membrane%3B Isomerase%3B Lipopolysaccharide biosynthesis%3B Magnesium%3B Membrane%3B Metal-binding%3B Phosphoprotein.%3B Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. Belongs to the phosphohexose mutase family%3B KEGG: bth:BT_3950 phosphomannomutase gene gene-HME7025_00918 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00918 HME7025_00919 HME7025_00919 iscS iscS 1048394 1049545 + Cysteine desulfurase Iron%3B Iron-sulfur%3B Metal-binding%3B Nitrogen fixation%3B Plasmid%3B Pyridoxal phosphate%3B Transferase.%3B Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily%3B KEGG: saq:Sare_3533 cysteine desulfurase gene gene-HME7025_00919 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00919 HME7025_00920 HME7025_00920 parS parS 1049542 1051014 - Proline--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)%3B Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily%3B KEGG: pml:ATP_00435 prolyl-tRNA synthetase gene gene-HME7025_00920 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00920 HME7025_00921 HME7025_00921 HME7025_00921 1051147 1052169 + hypothetical protein gene gene-HME7025_00921 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00921 HME7025_00922 HME7025_00922 HME7025_00922 1052181 1053737 + hypothetical protein gene gene-HME7025_00922 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00922 HME7025_00923 HME7025_00923 aroK aroK 1053738 1054259 - Shikimate kinase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate%3B Belongs to the shikimate kinase family%3B KEGG: aci:ACIAD3354 shikimate kinase gene gene-HME7025_00923 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00923 HME7025_00924 HME7025_00924 HME7025_00924 1054262 1055371 - Triose-phosphate isomerase KEGG: pmz:HMPREF0659_A5471 triosephosphate isomerase (TIM) gene gene-HME7025_00924 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00924 HME7025_00925 HME7025_00925 HME7025_00925 1055384 1055962 - hypothetical protein gene gene-HME7025_00925 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00925 HME7025_00926 HME7025_00926 folP folP 1056038 1056907 + Dihydropteroate synthase Folate biosynthesis%3B Magnesium%3B Metal-binding%3B Transferase.%3B Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7%2C8-dihydropterin diphosphate (DHPt-PP) to form 7%2C8-dihydropteroate (H2Pte)%2C the immediate precursor of folate derivatives%3B Belongs to the DHPS family%3B Contains 1 pterin-binding domain%3B KEGG: fjo:Fjoh_3497 dihydropteroate synthase gene gene-HME7025_00926 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00926 HME7025_00927 HME7025_00927 ilvE ilvE 1056885 1057700 + Branched-chain-amino-acid transaminase Aminotransferase%3B Pyridoxal phosphate%3B Transferase.%3B Acts on the D-isomers of alanine%2C leucine%2C aspartate%2C glutamate%2C aminobutyrate%2C norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction. The second half-reaction is the reverse of the first%2C transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D- amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate%2C which are essential bacterial cell wall components (By similarity)%3B Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: sli:Slin_5563 branched-chain amino acid aminotransferase gene gene-HME7025_00927 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00927 HME7025_00928 HME7025_00928 mogA mogA 1057697 1058224 - Molybdopterin adenylyltransferase ATP-binding%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor%3B Belongs to the MoaB/Mog family%3B KEGG: ote:Oter_2387 molybdopterin adenylyltransferase gene gene-HME7025_00928 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00928 HME7025_00929 HME7025_00929 HME7025_00929 1058221 1059018 - Molybdopterin-synthase adenylyltransferase ATP-binding%3B Metal-binding%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Zinc.%3B Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD%3B Belongs to the HesA/MoeB/ThiF family gene gene-HME7025_00929 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00929 HME7025_00930 HME7025_00930 HME7025_00930 1059021 1059986 - Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Cell membrane%3B Glycosyltransferase%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the glycosyltransferase 2 family. GtrB subfamily%3B KEGG: msd:MYSTI_06374 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase gene gene-HME7025_00930 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00930 HME7025_00931 HME7025_00931 yfiC yfiC 1060020 1060736 - tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase Cytoplasm%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing.%3B Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)%3B Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family%3B KEGG: hap:HAPS_1234 tRNA1Val (adenine37-N6)-methyltransferase gene gene-HME7025_00931 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00931 HME7025_00932 HME7025_00932 rnhA rnhA 1060723 1061349 - Ribonuclease H Cytoplasm%3B Endonuclease%3B Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nuclease.%3B Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase H family%3B Contains 1 RNase H domain%3B KEGG: bvu:BVU_1080 ribonuclease HI gene gene-HME7025_00932 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00932 HME7025_00933 HME7025_00933 HME7025_00933 1061352 1061921 - UPF0056 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0056 (MarC) family gene gene-HME7025_00933 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00933 HME7025_00934 HME7025_00934 HME7025_00934 1061923 1062987 - Phosphoserine transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Pyridoxine biosynthesis%3B Serine biosynthesis%3B Transferase.%3B Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily%3B KEGG: dfe:Dfer_5113 phosphoserine aminotransferase gene gene-HME7025_00934 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00934 HME7025_00935 HME7025_00935 aroQ aroQ 1062989 1063414 - 3-dehydroquinate dehydratase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Lyase.%3B Catalyzes a trans-dehydration via an enolate intermediate%3B Belongs to the type-II 3-dehydroquinase family%3B KEGG: aka:TKWG_06280 3-dehydroquinate dehydratase II gene gene-HME7025_00935 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00935 HME7025_00936 HME7025_00936 HME7025_00936 1063516 1064436 + Tyrosine recombinase XerC Cell cycle%3B Cell division%3B Chromosome partition%3B Cytoplasm%3B DNA integration%3B DNA recombination%3B DNA-binding.%3B Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerC subfamily gene gene-HME7025_00936 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00936 HME7025_00937 HME7025_00937 HME7025_00937 1065142 1065558 - hypothetical protein gene gene-HME7025_00937 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00937 HME7025_00938 HME7025_00938 pntA pntA 1065563 1066780 - NAD(P)(+) transhydrogenase (Re/Si-specific) NAD%3B Oxidoreductase.%3B May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer%3B Belongs to the AlaDH/PNT family%3B KEGG: eec:EcWSU1_01951 NAD(P) transhydrogenase subunit alpha gene gene-HME7025_00938 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00938 HME7025_00939 HME7025_00939 HME7025_00939 1066777 1067211 - tRNA threonylcarbamoyladenosine biosynthesis protein TsaE ATP-binding%3B Cytoplasm%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B tRNA processing.%3B Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway%2C possibly in regulating the core enzymatic function of TsaD (By similarity)%3B Belongs to the TsaE family gene gene-HME7025_00939 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00939 HME7025_00940 HME7025_00940 HME7025_00940 1067211 1067915 - Serine 3-dehydrogenase (NADP(+)) Antibiotic biosynthesis%3B NAD%3B Oxidoreductase.%3B Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin%2C an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the dehydrogenation of the C7-hydroxyl group in the 4S- tetrahydrotyrosine (4S-H4Tyr) to yield anticapsin (epoxycyclohexanonyl-Ala)%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: xfa:XF0145 serine 3-dehydrogenase gene gene-HME7025_00940 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00940 HME7025_00941 HME7025_00941 HME7025_00941 1067953 1068684 + Protein TRIGALACTOSYLDIACYLGLYCEROL 1%2C chloroplastic Chloroplast%3B Lipid transport%3B Membrane%3B Plastid%3B Plastid inner membrane%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Required during embryogenesis. Permease involved in lipid transfer from the endoplasmic reticulum (ER) to plastids%2C and necessary for thylakoids formation%3B Belongs to the MlaE permease family gene gene-HME7025_00941 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00941 HME7025_00942 HME7025_00942 HME7025_00942 1068681 1069535 - hypothetical protein gene gene-HME7025_00942 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00942 HME7025_00943 HME7025_00943 HME7025_00943 1069532 1070266 - hypothetical protein gene gene-HME7025_00943 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00943 HME7025_00944 HME7025_00944 HME7025_00944 1070321 1071283 - hypothetical protein gene gene-HME7025_00944 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00944 HME7025_00945 HME7025_00945 pyrD pyrD 1071466 1072500 + Dihydroorotate dehydrogenase (quinone) Cell membrane%3B Flavoprotein%3B FMN%3B Membrane%3B Oxidoreductase%3B Pyrimidine biosynthesis.%3B Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor%3B Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily%3B KEGG: hsw:Hsw_0431 dihydroorotate dehydrogenase gene gene-HME7025_00945 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00945 HME7025_00946 HME7025_00946 HME7025_00946 1072564 1075038 + DNA translocase FtsK ATP-binding%3B Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Chromosome partition%3B DNA-binding%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix.%3B Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site%2C which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites%2C where FtsK interacts with the Xer recombinase%2C allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates%2C but translocation stops specifically at XerCD-dif site%2C thereby preventing removal of XerC and XerD from dif (By similarity)%3B Belongs to the FtsK/SpoIIIE/SftA family%3B Contains 1 FtsK domain gene gene-HME7025_00946 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00946 HME7025_00947 HME7025_00947 HME7025_00947 1075046 1075654 + hypothetical protein gene gene-HME7025_00947 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00947 HME7025_00948 HME7025_00948 purL purL 1075786 1076463 - Phosphoribosylformylglycinamidine synthase ATP-binding%3B Cytoplasm%3B Glutamine amidotransferase%3B Hydrolase%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis.%3B Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: sli:Slin_6348 phosphoribosylformylglycinamidine synthase gene gene-HME7025_00948 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00948 HME7025_00949 HME7025_00949 HME7025_00949 1076520 1078118 - hypothetical protein gene gene-HME7025_00949 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00949 HME7025_00950 HME7025_00950 HME7025_00950 1078155 1078538 - hypothetical protein gene gene-HME7025_00950 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00950 HME7025_00951 HME7025_00951 ahcY ahcY 1078642 1079958 - Adenosylhomocysteinase Cytoplasm%3B Hydrolase%3B NAD%3B One-carbon metabolism.%3B May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine%3B Belongs to the adenosylhomocysteinase family%3B KEGG: rsi:Runsl_4706 adenosylhomocysteinase gene gene-HME7025_00951 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00951 HME7025_00952 HME7025_00952 HME7025_00952 1080313 1082838 - Protein flightless-1 like protein Acetylation%3B Actin-binding%3B Activator%3B Alternative splicing%3B Cell junction%3B Cytoplasm%3B Cytoskeleton%3B Developmental protein%3B Leucine-rich repeat%3B Nucleus%3B Phosphoprotein%3B Polymorphism%3B Repeat%3B Transcription%3B Transcription regulation.%3B May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration%2C by inhibiting Rac1-dependent paxillin phosphorylation%3B Contains 5 gelsolin-like repeats%3B Contains 15 LRR (leucine-rich) repeats gene gene-HME7025_00952 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00952 HME7025_00953 HME7025_00953 HME7025_00953 1082970 1083509 - hypothetical protein gene gene-HME7025_00953 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00953 HME7025_00954 HME7025_00954 murF murF 1083554 1084843 - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Magnesium%3B Nucleotide-binding%3B Peptidoglycan synthesis.%3B Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan%3B Belongs to the MurCDEF family. MurE subfamily%3B KEGG: bacc:BRDCF_01060 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase gene gene-HME7025_00954 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00954 HME7025_00955 HME7025_00955 HME7025_00955 1084885 1087008 + hypothetical protein gene gene-HME7025_00955 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00955 HME7025_00956 HME7025_00956 HME7025_00956 1087005 1087961 - UPF0721 transmembrane protein YtnM Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0721 family gene gene-HME7025_00956 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00956 HME7025_00957 HME7025_00957 larS larS 1088091 1090913 + Leucine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: dzc:W909_17325 leucyl-tRNA synthetase gene gene-HME7025_00957 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00957 HME7025_00958 HME7025_00958 HME7025_00958 1091053 1092549 - Arylsulfatase Calcium%3B Glycoprotein%3B Hydrolase%3B Metal-binding%3B Polymorphism%3B Secreted%3B Signal.%3B Belongs to the sulfatase family%3B KEGG: spl:Spea_1735 arylsulfatase gene gene-HME7025_00958 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00958 HME7025_00959 HME7025_00959 HME7025_00959 1092551 1093597 - hypothetical protein gene gene-HME7025_00959 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00959 HME7025_00960 HME7025_00960 HME7025_00960 1093600 1094805 - hypothetical protein gene gene-HME7025_00960 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00960 HME7025_00961 HME7025_00961 HME7025_00961 1094807 1095646 - hypothetical protein gene gene-HME7025_00961 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00961 HME7025_00962 HME7025_00962 HME7025_00962 1095648 1096706 - Glucose-fructose oxidoreductase KEGG: rba:RB3265 glucose-fructose oxidoreductase gene gene-HME7025_00962 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00962 HME7025_00963 HME7025_00963 HME7025_00963 1096763 1097119 - hypothetical protein gene gene-HME7025_00963 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00963 HME7025_00964 HME7025_00964 HME7025_00964 1097179 1098546 - hypothetical protein gene gene-HME7025_00964 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00964 HME7025_00965 HME7025_00965 HME7025_00965 1098548 1099753 - hypothetical protein gene gene-HME7025_00965 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00965 HME7025_00966 HME7025_00966 HME7025_00966 1099760 1100905 - 3-dehydroquinate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Cobalt%3B Cytoplasm%3B Lyase%3B NAD%3B Zinc.%3B Belongs to the dehydroquinate synthase family%3B KEGG: rsi:Runsl_2393 3-dehydroquinate synthase gene gene-HME7025_00966 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00966 HME7025_00967 HME7025_00967 ubiA ubiA 1100915 1101796 - 4-hydroxybenzoate polyprenyltransferase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Magnesium%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids%3B Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily%3B KEGG: eol:Emtol_0524 4-hydroxybenzoate polyprenyltransferase gene gene-HME7025_00967 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00967 HME7025_00968 HME7025_00968 HME7025_00968 1101796 1102809 - uncharacterized protein Signal.%3B To M. jannaschii MJ0761 gene gene-HME7025_00968 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00968 HME7025_00969 HME7025_00969 HME7025_00969 1102814 1103674 - hypothetical protein gene gene-HME7025_00969 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00969 HME7025_00970 HME7025_00970 HME7025_00970 1103775 1104764 - hypothetical protein gene gene-HME7025_00970 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00970 HME7025_00971 HME7025_00971 HME7025_00971 1106086 1107939 + UPF0313 protein 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine.%3B Belongs to the UPF0313 family gene gene-HME7025_00971 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00971 HME7025_00972 HME7025_00972 phnA phnA 1107954 1108163 + Phosphonoacetate hydrolase KEGG: eco:b4108 phosphonoacetate hydrolase gene gene-HME7025_00972 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00972 HME7025_00973 HME7025_00973 HME7025_00973 1108285 1108548 - hypothetical protein gene gene-HME7025_00973 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00973 HME7025_00974 HME7025_00974 HME7025_00974 1108686 1111340 - hypothetical protein gene gene-HME7025_00974 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00974 HME7025_00975 HME7025_00975 HME7025_00975 1111895 1112575 - Galactose/methyl galactoside import ATP-binding protein MglA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Repeat%3B Sugar transport%3B Transport.%3B Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3. A. 1. 2. 3) family%3B Contains 2 ABC transporter domains gene gene-HME7025_00975 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00975 HME7025_00976 HME7025_00976 HME7025_00976 1112572 1113489 - hypothetical protein gene gene-HME7025_00976 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00976 HME7025_00977 HME7025_00977 HME7025_00977 1114584 1115882 - DNA recombination protein RmuC like protein Coiled coil%3B DNA recombination.%3B Involved in DNA recombination%3B Belongs to the RmuC family gene gene-HME7025_00977 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00977 HME7025_00978 HME7025_00978 HME7025_00978 1116959 1117070 - 5S ribosomal RNA rRNA gene-HME7025_00978 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00978 HME7025_00979 HME7025_00979 HME7025_00979 1117139 1119968 - 23S ribosomal RNA rRNA gene-HME7025_00979 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00979 HME7025_00980 HME7025_00980 HME7025_00980 1120320 1120396 - tRNA-Ala tRNA gene-HME7025_00980 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00980 HME7025_00981 HME7025_00981 HME7025_00981 1120464 1120540 - tRNA-Ile tRNA gene-HME7025_00981 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00981 HME7025_00982 HME7025_00982 HME7025_00982 1120670 1122175 - 16S ribosomal RNA rRNA gene-HME7025_00982 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00982 HME7025_00983 HME7025_00983 yarS yarS 1122502 1123794 - Tyrosine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B RNA-binding.%3B Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)%3B Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily%3B Contains 1 S4 RNA-binding domain%3B KEGG: mtt:Ftrac_0320 tyrosyl-tRNA synthetase gene gene-HME7025_00983 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00983 HME7025_00984 HME7025_00984 queA queA 1123854 1125077 - S-adenosylmethionine:tRNA ribosyltransferase-isomerase Cytoplasm%3B Queuosine biosynthesis%3B S-adenosyl-L-methionine%3B Transferase.%3B Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)%3B Belongs to the QueA family%3B KEGG: ppn:Palpr_1550 S-adenosylmethionine:tRNA ribosyltransferase-isomerase gene gene-HME7025_00984 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00984 HME7025_00985 HME7025_00985 HME7025_00985 1125077 1125583 - hypothetical protein gene gene-HME7025_00985 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00985 HME7025_00986 HME7025_00986 mmaB mmaB 1125730 1126284 + Cob(I)yrinic acid a%2Cc-diamide adenosyltransferase ATP-binding%3B Cobalamin biosynthesis%3B Cytoplasm%3B Nucleotide-binding%3B Porphyrin biosynthesis%3B Transferase.%3B Belongs to the Cob(I)alamin adenosyltransferase family%3B KEGG: aha:AHA_1819 cob(I)alamin adenosyltransferase gene gene-HME7025_00986 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00986 HME7025_00987 HME7025_00987 HME7025_00987 1126300 1127355 + Branched-chain-amino-acid transaminase Acetylation%3B Alternative splicing%3B Amino-acid biosynthesis%3B Aminotransferase%3B Branched-chain amino acid biosynthesis%3B Cytoplasm%3B Mitochondrion%3B Polymorphism%3B Pyridoxal phosphate%3B Transferase%3B Transit peptide.%3B Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine%2C isoleucine%2C and valine. May also function as a transporter of branched chain alpha-keto acids. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: sli:Slin_1098 branched-chain amino acid aminotransferase gene gene-HME7025_00987 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00987 HME7025_00988 HME7025_00988 HME7025_00988 1127352 1127933 - hypothetical protein gene gene-HME7025_00988 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00988 HME7025_00989 HME7025_00989 HME7025_00989 1128130 1129536 - hypothetical protein gene gene-HME7025_00989 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00989 HME7025_00990 HME7025_00990 HME7025_00990 1129586 1131247 - Fatty acyl-CoA synthetase ATP-binding%3B Endosome%3B Fatty acid metabolism%3B Ligase%3B Lipid metabolism%3B Membrane%3B Nucleotide-binding.%3B Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: bmyo:BG05_4057 fatty-acyl-CoA synthase%3B Acid--thiol ligases gene gene-HME7025_00990 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00990 HME7025_00991 HME7025_00991 birA birA 1131269 1131979 - Biotin--[acetyl-CoA-carboxylase] ligase KEGG: cmq:B840_02595 BirA family transcriptional regulator%2C biotin operon repressor / biotin-(acetyl-CoA-carboxylase) ligase gene gene-HME7025_00991 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00991 HME7025_00992 HME7025_00992 HME7025_00992 1132148 1132534 + Ribosomal silencing factor RsfS Cytoplasm%3B Repressor%3B Translation regulation.%3B Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN)%2C blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes%2C thus repressing translation (By similarity)%3B Belongs to the Iojap/RsfS family gene gene-HME7025_00992 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00992 HME7025_00993 HME7025_00993 ftsH ftsH 1132613 1134748 + ATP-dependent zinc metalloprotease FtsH ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Nucleotide-binding%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Zinc.%3B Acts as a processive%2C ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins%3B In the central sectio%3B belongs to the AAA ATPase family%3B In the C-terminal sectio%3B belongs to the peptidase M41 family%3B KEGG: hyd:PK28_14770 cell division protease FtsH%3B Metalloendopeptidases gene gene-HME7025_00993 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00993 HME7025_00994 HME7025_00994 lpxH lpxH 1134784 1135596 + UDP-2%2C3-diacylglucosamine diphosphatase KEGG: osp:Odosp_2267 UDP-2%2C3-diacylglucosamine hydrolase gene gene-HME7025_00994 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00994 HME7025_00995 HME7025_00995 fruA fruA 1135562 1137076 + Fructan beta-fructosidase Cell wall%3B Glycoprotein%3B Glycosidase%3B Hydrolase%3B Secreted%3B Signal%3B Zymogen.%3B May play an important role in phloem unloading and in stress response. Belongs to the glycosyl hydrolase 32 family%3B KEGG: vej:VEJY3_21426 fructan beta-fructosidase gene gene-HME7025_00995 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00995 HME7025_00996 HME7025_00996 HME7025_00996 1137142 1138122 + Stearoyl-[acyl-carrier-protein] 9-desaturase Chloroplast%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Iron%3B Lipid biosynthesis%3B Lipid metabolism%3B Metal-binding%3B Oxidoreductase%3B Plastid%3B Transit peptide.%3B Delta(6) fatty acid desaturase introducing a cis double bond at carbon 6 of palmitoyl-[acyl-carrier protein](16:0-ACP)%2C producing 16:1(6Z)-ACP (PubMed:7961667%2C PubMed:9144157). No activity with the coenzyme A ester of the fatty acid (PubMed:7961667). The position of the double bond is determined by its distance from the carboxyl end of the fatty acid (PubMed:7961667). Low activity with several saturated acyl-[acyl- carrier protein]s%2C including 14:0-ACP and 18:0-ACP (PubMed:7961667%2C PubMed:9144157). Requires reduced ferredoxin for detectable in vitro activity (PubMed:7961667)%3B Belongs to the fatty acid desaturase family%3B KEGG: fba:FIC_01332 acyl-(acyl-carrier-protein) desaturase gene gene-HME7025_00996 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00996 HME7025_00997 HME7025_00997 rlmB rlmB 1138139 1138675 + 23S rRNA (guanosine(2251)-2'-O)-methyltransferase KEGG: cid:P73_3236 23S rRNA (guanosine2251-2'-O)-methyltransferase gene gene-HME7025_00997 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00997 HME7025_00998 HME7025_00998 HME7025_00998 1138775 1139191 + hypothetical protein gene gene-HME7025_00998 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00998 HME7025_00999 HME7025_00999 afuC afuC 1139290 1140198 + Fe(3+)-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Sulfate transport%3B Transport.%3B Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3. A. 1. 6) family%3B Contains 1 ABC transporter domain%3B KEGG: ype:YPO3048 iron(III) transport system ATP-binding protein gene gene-HME7025_00999 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_00999 HME7025_01000 HME7025_01000 HME7025_01000 1140209 1141528 + uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B To M. jannaschii MJ1024 gene gene-HME7025_01000 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01000 HME7025_01001 HME7025_01001 HME7025_01001 1141849 1142121 + hypothetical protein gene gene-HME7025_01001 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01001 HME7025_01002 HME7025_01002 HME7025_01002 1142260 1142895 + UPF0126 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0126 family gene gene-HME7025_01002 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01002 HME7025_01003 HME7025_01003 HME7025_01003 1143110 1144282 + hypothetical protein gene gene-HME7025_01003 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01003 HME7025_01004 HME7025_01004 arsC arsC 1144287 1144637 - Arsenate reductase (glutaredoxin) Belongs to the ArsC family%3B KEGG: ppu:PP_1531 arsenate reductase gene gene-HME7025_01004 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01004 HME7025_01005 HME7025_01005 fumC fumC 1144727 1146130 + Fumarate hydratase Allosteric enzyme%3B Cytoplasm%3B Lyase%3B Tricarboxylic acid cycle.%3B Catalyzes the reversible addition of water to fumarate to give L-malate%3B Belongs to the class-II fumarase/aspartase family. Fumarase subfamily%3B KEGG: hit:NTHI1749 fumarate hydratase%2C class II gene gene-HME7025_01005 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01005 HME7025_01006 HME7025_01006 HME7025_01006 1146210 1146545 - hypothetical protein gene gene-HME7025_01006 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01006 HME7025_01007 HME7025_01007 HME7025_01007 1146567 1146926 - Transcriptional repressor SdpR Cytoplasm%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation.%3B Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation%3B Contains 1 HTH arsR-type DNA-binding domain gene gene-HME7025_01007 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01007 HME7025_01008 HME7025_01008 HME7025_01008 1147314 1149770 - Alanine racemase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Peptidoglycan synthesis.%3B Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide%2C the precursor of murein%3B Belongs to the MurCDEF family. MurF subfamily%3B KEGG: osp:Odosp_3305 alanine racemase gene gene-HME7025_01008 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01008 HME7025_01009 HME7025_01009 HME7025_01009 1149863 1151053 - Phosphoglycerate kinase ATP-binding%3B Cytoplasm%3B Glycolysis%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Belongs to the phosphoglycerate kinase family%3B KEGG: bfr:BF3269 phosphoglycerate kinase gene gene-HME7025_01009 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01009 HME7025_01010 HME7025_01010 dnaQ dnaQ 1151216 1152892 + DNA-directed DNA polymerase DNA damage%3B DNA repair%3B Endonuclease%3B Exonuclease%3B Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nuclease.%3B Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide%2C allowing to excise an ICL from one strand through flanking incisions. Also has endonuclease activity toward 5'-flaps (PubMed:25319828)%3B Belongs to the FAN1 family%3B Contains 1 VRR-NUC domain%3B KEGG: bra:BRADO4398 DNA polymerase III subunit epsilon gene gene-HME7025_01010 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01010 HME7025_01011 HME7025_01011 HME7025_01011 1153090 1153425 + hypothetical protein gene gene-HME7025_01011 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01011 HME7025_01012 HME7025_01012 metK metK 1153489 1154745 - Methionine adenosyltransferase ATP-binding%3B Cobalt%3B Cytoplasm%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B One-carbon metabolism%3B Potassium%3B Transferase.%3B Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps%2C AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme%3B Belongs to the AdoMet synthase family%3B KEGG: hcm:HCD_00280 S-adenosylmethionine synthetase gene gene-HME7025_01012 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01012 HME7025_01013 HME7025_01013 lcyB lcyB 1154838 1156019 - Lycopene beta-cyclase KEGG: eol:Emtol_4266 lycopene beta-cyclase gene gene-HME7025_01013 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01013 HME7025_01014 HME7025_01014 lipA lipA 1156026 1156895 - Lipoyl synthase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes%2C thereby converting the octanoylated domains into lipoylated derivatives%3B Belongs to the radical SAM superfamily. Lipoyl synthase family%3B KEGG: aym:YM304_29640 lipoic acid synthetase gene gene-HME7025_01014 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01014 HME7025_01015 HME7025_01015 HME7025_01015 1156902 1157738 - hypothetical protein gene gene-HME7025_01015 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01015 HME7025_01016 HME7025_01016 HME7025_01016 1157740 1158096 - uncharacterized protein gene gene-HME7025_01016 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01016 HME7025_01017 HME7025_01017 kdtA kdtA 1158139 1159389 + Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase KEGG: bbd:Belba_1597 3-deoxy-D-manno-octulosonic-acid transferase gene gene-HME7025_01017 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01017 HME7025_01018 HME7025_01018 rsgA rsgA 1159382 1160320 + Putative ribosome bioproteinis GTPase RsgA GTP-binding%3B Hydrolase%3B Metal-binding%3B Nucleotide-binding%3B Zinc.%3B May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover%3B Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily%3B Contains 1 CP-type G (guanine nucleotide-binding) domain%3B KEGG: sli:Slin_5830 ribosome biogenesis GTPase%3B In phosphorus-containing anhydrides gene gene-HME7025_01018 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01018 HME7025_01019 HME7025_01019 nagK nagK 1160334 1161251 + N-acetylglucosamine kinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the phosphorylation of fructose to fructose-6- P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose%2C D-mannitol%2C D-sorbitol%2C inositol%2C and L-threonine%3B Belongs to the ROK (NagC/XylR) family%3B KEGG: ara:Arad_4024 N-acetylglucosamine kinase gene gene-HME7025_01019 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01019 HME7025_01020 HME7025_01020 HME7025_01020 1161323 1162429 - Alpha-N-acetylglucosaminidase KEGG: xfu:XFF4834R_chr07180 alpha-N-acetylglucosaminidase gene gene-HME7025_01020 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01020 HME7025_01021 HME7025_01021 HME7025_01021 1162436 1164097 - Lactocepin KEGG: cpo:COPRO5265_0081 lactocepin gene gene-HME7025_01021 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01021 HME7025_01022 HME7025_01022 HME7025_01022 1164118 1164555 + hypothetical protein gene gene-HME7025_01022 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01022 HME7025_01023 HME7025_01023 HME7025_01023 1164604 1166838 + hypothetical protein gene gene-HME7025_01023 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01023 HME7025_01024 HME7025_01024 HME7025_01024 1166850 1167068 + hypothetical protein gene gene-HME7025_01024 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01024 HME7025_01025 HME7025_01025 HME7025_01025 1167068 1167409 + hypothetical protein gene gene-HME7025_01025 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01025 HME7025_01026 HME7025_01026 HME7025_01026 1167532 1169658 - Protein tex RNA-binding.%3B Transcription accessory protein. Exact function not known. Contains 1 S1 motif domain gene gene-HME7025_01026 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01026 HME7025_01027 HME7025_01027 HME7025_01027 1169685 1170389 - hypothetical protein gene gene-HME7025_01027 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01027 HME7025_01028 HME7025_01028 dpo4 dpo4 1170435 1171685 + DNA-directed DNA polymerase Cytoplasm%3B DNA damage%3B DNA repair%3B DNA replication%3B DNA-binding%3B DNA-directed DNA polymerase%3B Magnesium%3B Metal-binding%3B Mutator protein%3B Nucleotidyltransferase%3B Transferase.%3B Poorly processive%2C error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks%2C which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis%2C in conjunction with the beta clamp from PolIII (By similarity)%3B Belongs to the DNA polymerase type-Y family%3B Contains 1 umuC domain%3B KEGG: aai:AARI_20850 DNA polymerase IV gene gene-HME7025_01028 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01028 HME7025_01029 HME7025_01029 dnaE dnaE 1171685 1174603 + DNA-directed DNA polymerase Cytoplasm%3B DNA replication%3B DNA-directed DNA polymerase%3B Nucleotidyltransferase%3B Transferase.%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity)%3B Belongs to the DNA polymerase type-C family. DnaE subfamily%3B KEGG: cpi:Cpin_3236 DNA polymerase III subunit alpha gene gene-HME7025_01029 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01029 HME7025_01030 HME7025_01030 HME7025_01030 1174676 1175488 - hypothetical protein gene gene-HME7025_01030 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01030 HME7025_01031 HME7025_01031 HME7025_01031 1175616 1176317 - hypothetical protein gene gene-HME7025_01031 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01031 HME7025_01032 HME7025_01032 HME7025_01032 1176435 1176800 - hypothetical protein gene gene-HME7025_01032 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01032 HME7025_01033 HME7025_01033 HME7025_01033 1176827 1177270 - hypothetical protein gene gene-HME7025_01033 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01033 HME7025_01034 HME7025_01034 HME7025_01034 1177354 1178019 - hypothetical protein gene gene-HME7025_01034 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01034 HME7025_01035 HME7025_01035 HME7025_01035 1178244 1178669 + hypothetical protein gene gene-HME7025_01035 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01035 HME7025_01036 HME7025_01036 HME7025_01036 1178693 1179493 + hypothetical protein gene gene-HME7025_01036 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01036 HME7025_01037 HME7025_01037 msrB msrB 1179697 1180182 + Peptide-methionine (R)-S-oxide reductase Metal-binding%3B Oxidoreductase%3B Zinc.%3B Belongs to the MsrB Met sulfoxide reductase family%3B KEGG: fgi:OP10G_4420 peptide-methionine (R)-S-oxide reductase gene gene-HME7025_01037 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01037 HME7025_01038 HME7025_01038 gloB gloB 1180285 1180989 - Hydroxyacylglutathione hydrolase Alternative splicing%3B Cytoplasm%3B Transferase.%3B Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds. Substrate preference is thiosulfate > 3-mercaptopyruvate%3B Contains 1 rhodanese domain%3B KEGG: dpd:Deipe_2472 hydroxyacylglutathione hydrolase gene gene-HME7025_01038 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01038 HME7025_01039 HME7025_01039 trxC trxC 1181178 1181474 - Protein-disulfide reductase Cytoplasm%3B Disulfide bond%3B Electron transport%3B FAD%3B Flavoprotein%3B NADP%3B Oxidoreductase%3B Redox-active center%3B Transport.%3B In the N-terminal sectio%3B belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family%3B Contains 1 thioredoxin domain%3B KEGG: vpa:VPA0972 thioredoxin 2 gene gene-HME7025_01039 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01039 HME7025_01040 HME7025_01040 HME7025_01040 1181501 1181803 - hypothetical protein gene gene-HME7025_01040 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01040 HME7025_01041 HME7025_01041 HME7025_01041 1181879 1182481 - hypothetical protein gene gene-HME7025_01041 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01041 HME7025_01042 HME7025_01042 HME7025_01042 1182511 1182927 + hypothetical protein gene gene-HME7025_01042 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01042 HME7025_01043 HME7025_01043 HME7025_01043 1182978 1184171 - Sulfide:quinone oxidoreductase%2C mitochondrial Acetylation%3B FAD%3B Flavoprotein%3B Mitochondrion%3B Oxidoreductase%3B Phosphoprotein%3B Polymorphism%3B Quinone%3B Transit peptide.%3B Catalyzes the oxidation of hydrogen sulfide with the help of a quinone%2C such as ubiquinone%2C giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron accepto%3B can use sulfite%2C sulfide or cyanide (in vitro)%3B Belongs to the SQRD family%3B KEGG: tmo:TMO_1482 sulfide:quinone oxidoreductase%3B With a quinone or similar compound as acceptor gene gene-HME7025_01043 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01043 HME7025_01044 HME7025_01044 HME7025_01044 1184251 1185345 + Thiosulfate dehydrogenase Heme%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Periplasm%3B Repeat%3B Signal.%3B Catalyzes the oxidation of 2 molecules of thiosulfate to tetrathionate%2C using TsdB as an electron acceptor%3B Contains 2 cytochrome c domains gene gene-HME7025_01044 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01044 HME7025_01045 HME7025_01045 HME7025_01045 1185350 1187020 + 5'-nucleotidase KEGG: gfo:GFO_1276 5'-nucleotidase gene gene-HME7025_01045 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01045 HME7025_01046 HME7025_01046 HME7025_01046 1188651 1189238 - hypothetical protein gene gene-HME7025_01046 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01046 HME7025_01047 HME7025_01047 HME7025_01047 1189232 1189741 - hypothetical protein gene gene-HME7025_01047 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01047 HME7025_01048 HME7025_01048 HME7025_01048 1190014 1190523 - hypothetical protein gene gene-HME7025_01048 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01048 HME7025_01049 HME7025_01049 HME7025_01049 1190529 1191092 - hypothetical protein gene gene-HME7025_01049 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01049 HME7025_01050 HME7025_01050 HME7025_01050 1191209 1191418 - hypothetical protein gene gene-HME7025_01050 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01050 HME7025_01051 HME7025_01051 HME7025_01051 1191393 1191644 - hypothetical protein gene gene-HME7025_01051 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01051 HME7025_01052 HME7025_01052 HME7025_01052 1191649 1191930 - hypothetical protein gene gene-HME7025_01052 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01052 HME7025_01053 HME7025_01053 HME7025_01053 1191933 1193351 - Hydroxyacylglutathione hydrolase Contains 1 rhodanese domain%3B KEGG: tmb:Thimo_0160 hydroxyacylglutathione hydrolase gene gene-HME7025_01053 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01053 HME7025_01054 HME7025_01054 HME7025_01054 1193400 1194221 - UPF0721 transmembrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0721 family gene gene-HME7025_01054 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01054 HME7025_01055 HME7025_01055 HME7025_01055 1194394 1195788 - hypothetical protein gene gene-HME7025_01055 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01055 HME7025_01056 HME7025_01056 HME7025_01056 1195949 1196590 - hypothetical protein gene gene-HME7025_01056 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01056 HME7025_01057 HME7025_01057 HME7025_01057 1196595 1197641 - Scyllo-inositol 2-dehydrogenase (NADP(+)) NADP%3B Oxidoreductase.%3B Catalyzes the NADP(+)-dependent oxidation of scyllo- inositol to 2%2C4%2C6/3%2C5-pentahydroxycyclohexanone (scyllo-inosose)%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: bao:BAMF_3201 scyllo-inositol 2-dehydrogenase (NADP+) gene gene-HME7025_01057 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01057 HME7025_01058 HME7025_01058 pnbA pnbA 1197680 1199326 - Carboxylesterase Alternative splicing%3B Disulfide bond%3B Endoplasmic reticulum%3B Glycoprotein%3B Hydrolase%3B Serine esterase%3B Signal.%3B Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Belongs to the type-B carboxylesterase/lipase family%3B KEGG: srd:SD10_15870 para-nitrobenzyl esterase%3B Carboxylic ester hydrolases gene gene-HME7025_01058 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01058 HME7025_01059 HME7025_01059 HME7025_01059 1199435 1200268 + ADP-dependent NAD(P)H-hydrate dehydratase ATP-binding%3B Isomerase%3B Lyase%3B Metal-binding%3B Multifunctional enzyme%3B NAD%3B NADP%3B Nucleotide-binding%3B Potassium.%3B Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP%2C which is converted to AMP. This allows the repair of both epimers of NAD(P)HX%2C a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)%3B In the N-terminal sectio%3B belongs to the NnrE/AIBP family%3B In the C-terminal sectio%3B belongs to the NnrD/CARKD family%3B Contains 1 YjeF C-terminal domain%3B Contains 1 YjeF N-terminal domain%3B KEGG: tye:THEYE_A0332 ADP-dependent NAD(P)H-hydrate dehydratase gene gene-HME7025_01059 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01059 HME7025_01060 HME7025_01060 HME7025_01060 1200490 1201518 - hypothetical protein gene gene-HME7025_01060 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01060 HME7025_01061 HME7025_01061 nylB nylB 1201641 1203185 - 6-aminohexanoate-oligomer exohydrolase KEGG: pac:PPA1511 6-aminohexanoate-oligomer exohydrolase gene gene-HME7025_01061 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01061 HME7025_01062 HME7025_01062 HME7025_01062 1203331 1204911 + Alpha-ketoglutarate permease Cell inner membrane%3B Cell membrane%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system)%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene-HME7025_01062 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01062 HME7025_01063 HME7025_01063 HME7025_01063 1204913 1205131 + hypothetical protein gene gene-HME7025_01063 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01063 HME7025_01064 HME7025_01064 acsS acsS 1205150 1207057 + Acetate--CoA ligase Acetylation%3B ATP-binding%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding.%3B Catalyzes the conversion of acetate into acetyl-CoA (AcCoA)%2C an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction%2C AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction%2C it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA%2C forming the product AcCoA%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: sgn:SGRA_3448 acetyl-CoA synthetase gene gene-HME7025_01064 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01064 HME7025_01065 HME7025_01065 HME7025_01065 1207059 1208486 + putative ABC transporter ATP-binding protein ATP-binding%3B Mitochondrion%3B Nucleotide-binding%3B Repeat.%3B Belongs to the ABC transporter superfamily%3B Contains 2 ABC transporter domains gene gene-HME7025_01065 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01065 HME7025_01066 HME7025_01066 pepQ pepQ 1208696 1209925 - Xaa-Pro dipeptidase Aminopeptidase%3B Hydrolase%3B Metal-binding%3B Protease.%3B Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-%2C Cys%2C Gly%2C Pro%2C Ser%2C Thr%2C or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed%3B Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily%3B KEGG: pat:Patl_3488 Xaa-Pro dipeptidase gene gene-HME7025_01066 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01066 HME7025_01067 HME7025_01067 HME7025_01067 1210276 1213383 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_01067 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01067 HME7025_01068 HME7025_01068 HME7025_01068 1213444 1214928 + hypothetical protein gene gene-HME7025_01068 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01068 HME7025_01069 HME7025_01069 HME7025_01069 1214991 1216196 + hypothetical protein gene gene-HME7025_01069 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01069 HME7025_01070 HME7025_01070 HME7025_01070 1216264 1217046 + hypothetical protein gene gene-HME7025_01070 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01070 HME7025_01071 HME7025_01071 HME7025_01071 1217061 1219799 + hypothetical protein gene gene-HME7025_01071 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01071 HME7025_01072 HME7025_01072 HME7025_01072 1219814 1220875 + hypothetical protein gene gene-HME7025_01072 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01072 HME7025_01073 HME7025_01073 HME7025_01073 1220892 1222100 + hypothetical protein gene gene-HME7025_01073 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01073 HME7025_01074 HME7025_01074 HME7025_01074 1222123 1223154 + hypothetical protein gene gene-HME7025_01074 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01074 HME7025_01075 HME7025_01075 HME7025_01075 1223176 1224333 + Inositol 2-dehydrogenase Oxidoreductase.%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: rsp:RSP_3670 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_01075 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01075 HME7025_01076 HME7025_01076 HME7025_01076 1224342 1225847 + putative ATP-dependent transporter ycf16 ATP-binding%3B Chloroplast%3B Nucleotide-binding%3B Plastid%3B Transport.%3B Belongs to the ABC transporter superfamily. Ycf16 family%3B Contains 1 ABC transporter domain gene gene-HME7025_01076 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01076 HME7025_01077 HME7025_01077 HME7025_01077 1225855 1226802 + Galactoside transport system permease protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily gene gene-HME7025_01077 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01077 HME7025_01078 HME7025_01078 HME7025_01078 1226804 1227715 + D-ribose-binding protein Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Sugar transport%3B Transport.%3B Involved in the high-affinity D-ribose membrane transport system. Belongs to the bacterial solute-binding protein 2 family gene gene-HME7025_01078 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01078 HME7025_01079 HME7025_01079 HME7025_01079 1227781 1228983 + Endo-1%2C4-beta-xylanase KEGG: cki:Calkr_2245 endo-1%2C4-beta-xylanase gene gene-HME7025_01079 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01079 HME7025_01080 HME7025_01080 HME7025_01080 1229022 1229459 + hypothetical protein gene gene-HME7025_01080 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01080 HME7025_01081 HME7025_01081 HME7025_01081 1229640 1230527 + hypothetical protein gene gene-HME7025_01081 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01081 HME7025_01082 HME7025_01082 HME7025_01082 1230549 1231976 + p-aminobenzoyl-glutamate hydrolase subunit Hydrolase.%3B Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified%3B KEGG: lby:Lbys_1236 amidohydrolase%3B In linear amides gene gene-HME7025_01082 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01082 HME7025_01083 HME7025_01083 HME7025_01083 1231989 1232513 + hypothetical protein gene gene-HME7025_01083 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01083 HME7025_01084 HME7025_01084 HME7025_01084 1232708 1233373 + hypothetical protein gene gene-HME7025_01084 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01084 HME7025_01085 HME7025_01085 HME7025_01085 1233546 1235930 - hypothetical protein gene gene-HME7025_01085 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01085 HME7025_01086 HME7025_01086 HME7025_01086 1236148 1236573 + hypothetical protein gene gene-HME7025_01086 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01086 HME7025_01087 HME7025_01087 HME7025_01087 1236597 1237397 + hypothetical protein gene gene-HME7025_01087 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01087 HME7025_01088 HME7025_01088 HME7025_01088 1237506 1238933 - Poly-beta-1%2C6-N-acetyl-D-glucosamine synthase Cell membrane%3B Glycosyltransferase%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1%2C6-N-acetyl-D- glucosamine (PNAG%2C also referred to as PIA)%2C a biofilm adhesin polysaccharide. Requires IcaD for full activity%3B Belongs to the glycosyltransferase 2 family%3B KEGG: gfo:GFO_0844 null%3B Glycosyltransferases gene gene-HME7025_01088 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01088 HME7025_01089 HME7025_01089 HME7025_01089 1238935 1239777 - hypothetical protein gene gene-HME7025_01089 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01089 HME7025_01090 HME7025_01090 evgS evgS 1239794 1240153 - Histidine kinase Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system.%3B Essential protein that plays a role in the control of cell division%2C possibly through the transcriptional regulation of ccrM%2C rpoD%2C pleC%2C minC and ftsZ genes%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain%3B KEGG: eco:b2370 two-component system%2C NarL family%2C sensor histidine kinase EvgS gene gene-HME7025_01090 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01090 HME7025_01091 HME7025_01091 HME7025_01091 1240219 1243830 - Aerotaxis receptor Cell inner membrane%3B Cell membrane%3B Chemotaxis%3B FAD%3B Flavoprotein%3B Membrane%3B Methylation%3B Transducer%3B Transmembrane%3B Transmembrane helix.%3B Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels%3B Contains 1 methyl-accepting transducer domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: ava:Ava_1564 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene-HME7025_01091 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01091 HME7025_01092 HME7025_01092 HME7025_01092 1244086 1244403 - hypothetical protein gene gene-HME7025_01092 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01092 HME7025_01093 HME7025_01093 HME7025_01093 1244533 1245621 + hypothetical protein gene gene-HME7025_01093 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01093 HME7025_01094 HME7025_01094 HME7025_01094 1245733 1246326 - hypothetical protein gene gene-HME7025_01094 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01094 HME7025_01095 HME7025_01095 HME7025_01095 1246905 1246977 - tRNA-Thr tRNA gene-HME7025_01095 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01095 HME7025_01096 HME7025_01096 HME7025_01096 1247052 1248974 - hypothetical protein gene gene-HME7025_01096 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01096 HME7025_01097 HME7025_01097 garS garS 1248989 1250470 - Glycine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Catalyzes the attachment of glycine to tRNA(Gly)%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: lil:LA_1388 glycyl-tRNA synthetase gene gene-HME7025_01097 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01097 HME7025_01098 HME7025_01098 HME7025_01098 1250567 1251532 + hypothetical protein gene gene-HME7025_01098 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01098 HME7025_01099 HME7025_01099 aguB aguB 1251529 1252395 + N-carbamoylputrescine amidase Hydrolase%3B Polyamine biosynthesis.%3B Involved in polyamine biosynthesis%3B Belongs to the carbon-nitrogen hydrolase superfamily%3B Contains 1 CN hydrolase domain%3B KEGG: vfu:vfu_A02171 N-carbamoylputrescine amidase gene gene-HME7025_01099 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01099 HME7025_01100 HME7025_01100 rgpB rgpB 1252712 1253704 - Chondroitin synthase Glycosyltransferase%3B Repeat%3B Transferase.%3B Catalyzes the polymerization of chondroitin%2C a polysaccharide composed of a repeating disaccharide of N- acetylgalactosamine (GalNAc) and glucuronic acid (GlcUA) units. Each unit has the composition in beta-(1->4)-GlcUA-beta-(1->3)- GalNAc. Belongs to the glycosyltransferase 2 family. CS/HAS subfamily%3B KEGG: tco:Theco_3910 rhamnosyltransferase%3B Hexosyltransferases gene gene-HME7025_01100 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01100 HME7025_01101 HME7025_01101 dpo1 dpo1 1253715 1256564 - DNA-directed DNA polymerase DNA damage%3B DNA repair%3B DNA replication%3B DNA-binding%3B DNA-directed DNA polymerase%3B Exonuclease%3B Hydrolase%3B Nuclease%3B Nucleotidyltransferase%3B Transferase.%3B In addition to polymerase activity%2C this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity%3B Belongs to the DNA polymerase type-A family%3B Contains 1 3'-5' exonuclease domain%3B Contains 1 5'-3' exonuclease domain%3B KEGG: pdt:Prede_1454 DNA polymerase I gene gene-HME7025_01101 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01101 HME7025_01102 HME7025_01102 pdxH pdxH 1256630 1257262 + Pyridoxal 5'-phosphate synthase Flavoprotein%3B FMN%3B Oxidoreductase%3B Pyridoxine biosynthesis.%3B Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)%3B Belongs to the pyridoxamine 5'-phosphate oxidase family%3B KEGG: nca:Noca_0734 pyridoxamine 5'-phosphate oxidase gene gene-HME7025_01102 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01102 HME7025_01103 HME7025_01103 HME7025_01103 1257375 1258175 - hypothetical protein gene gene-HME7025_01103 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01103 HME7025_01104 HME7025_01104 HME7025_01104 1258199 1258624 - hypothetical protein gene gene-HME7025_01104 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01104 HME7025_01105 HME7025_01105 HME7025_01105 1259037 1259759 - hypothetical protein gene gene-HME7025_01105 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01105 HME7025_01106 HME7025_01106 lytM lytM 1259759 1260856 - Lysostaphin Cell membrane%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Zinc.%3B Belongs to the peptidase M23B family%3B KEGG: ava:Ava_3195 lysostaphin gene gene-HME7025_01106 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01106 HME7025_01107 HME7025_01107 trxB trxB 1260866 1261804 - Thioredoxin-disulfide reductase Disulfide bond%3B FAD%3B Flavoprotein%3B Lyase%3B Oxidoreductase%3B Redox-active center.%3B Catalyzes the conversion of D-glucosaminate (GlcNA) to 2-keto-3-deoxy-D-gluconic acid (KDGA) and ammonia%3B Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: pdi:BDI_0401 thioredoxin reductase (NADPH) gene gene-HME7025_01107 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01107 HME7025_01108 HME7025_01108 HME7025_01108 1261935 1263194 + C4-dicarboxylate transport protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane. This transport system plays an important role in the energy supply of rhizobium-legume symbionts (By similarity)%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene-HME7025_01108 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01108 HME7025_01109 HME7025_01109 maeB maeB 1263216 1265492 + Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Metal-binding%3B Multifunctional enzyme%3B NADP%3B Oxidoreductase.%3B In the N-terminal sectio%3B belongs to the malic enzymes family%3B In the C-terminal sectio%3B belongs to the phosphate acetyltransferase and butyryltransferase family%3B KEGG: bvs:BARVI_12920 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) gene gene-HME7025_01109 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01109 HME7025_01110 HME7025_01110 HME7025_01110 1265482 1267332 - hypothetical protein gene gene-HME7025_01110 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01110 HME7025_01111 HME7025_01111 HME7025_01111 1267335 1268549 - Lipoprotein-releasing system transmembrane protein LolC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity)%3B Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily gene gene-HME7025_01111 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01111 HME7025_01112 HME7025_01112 HME7025_01112 1268681 1269802 + Beta-N-acetylhexosaminidase Signal.%3B KEGG: hhd:HBHAL_2473 beta-N-acetylhexosaminidase gene gene-HME7025_01112 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01112 HME7025_01113 HME7025_01113 guaA guaA 1269875 1271398 + GMP synthase (glutamine-hydrolyzing) ATP-binding%3B Glutamine amidotransferase%3B GMP biosynthesis%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis.%3B Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B KEGG: afe:Lferr_1454 GMP synthase (glutamine-hydrolysing) gene gene-HME7025_01113 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01113 HME7025_01114 HME7025_01114 pepT pepT 1271525 1272793 - Tripeptide aminopeptidase Aminopeptidase%3B Cytoplasm%3B Hydrolase%3B Metal-binding%3B Metalloprotease%3B Protease%3B Zinc.%3B Cleaves the N-terminal amino acid of tripeptides%3B Belongs to the peptidase M20B family%3B KEGG: nko:Niako_4577 tripeptide aminopeptidase gene gene-HME7025_01114 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01114 HME7025_01115 HME7025_01115 gltA gltA 1272977 1274248 + Citrate (Si)-synthase Allosteric enzyme%3B Transferase%3B Tricarboxylic acid cycle.%3B Belongs to the citrate synthase family%3B KEGG: tvi:Thivi_0521 citrate synthase gene gene-HME7025_01115 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01115 HME7025_01116 HME7025_01116 HME7025_01116 1274353 1274853 + RlpA-like lipoprotein Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal.%3B Belongs to the RlpA family%3B Contains 1 SPOR domain gene gene-HME7025_01116 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01116 HME7025_01117 HME7025_01117 HME7025_01117 1275009 1276256 - Photosystem I P700 chlorophyll a apoprotein A2 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Chlorophyll%3B Chromophore%3B Electron transport%3B Iron%3B Iron-sulfur%3B Magnesium%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Photosynthesis%3B Photosystem I%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B PsaA and PsaB bind P700%2C the primary electron donor of photosystem I (PSI)%2C as well as the electron acceptors A0%2C A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase%2C converting photonic excitation into a charge separation%2C which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0%2C A1%2C FX%2C FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6. Belongs to the PsaA/PsaB family%3B Contains 1 OmpA-like domain gene gene-HME7025_01117 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01117 HME7025_01118 HME7025_01118 queE queE 1276260 1276907 - 7-carboxy-7-deazaguanine synthase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B Queuosine biosynthesis%3B S-adenosyl-L-methionine.%3B Catalyzes the conversion of 6-carboxy-5%2C6%2C7%2C8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG)%3B Belongs to the radical SAM superfamily. 7-carboxy-7- deazaguanine synthase family%3B KEGG: vba:IMCC26134_01150 7-carboxy-7-deazaguanine synthase gene gene-HME7025_01118 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01118 HME7025_01119 HME7025_01119 HME7025_01119 1277009 1277314 + hypothetical protein gene gene-HME7025_01119 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01119 HME7025_01120 HME7025_01120 qns1 qns1 1277320 1279251 + NAD(+) synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B NAD%3B Nucleotide-binding.%3B In the C-terminal sectio%3B belongs to the NAD synthetase family%3B Contains 1 CN hydrolase domain%3B KEGG: ote:Oter_1045 NAD+ synthase (glutamine-hydrolysing) gene gene-HME7025_01120 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01120 HME7025_01121 HME7025_01121 HME7025_01121 1279255 1280022 + Pantothenate kinase ATP-binding%3B Coenzyme A biosynthesis%3B Cytoplasm%3B Kinase%3B Metal-binding%3B Nucleotide-binding%3B Potassium%3B Transferase.%3B Catalyzes the phosphorylation of pantothenate (Pan)%2C the first step in CoA biosynthesis%3B Belongs to the type III pantothenate kinase family%3B KEGG: gsu:GSU1934 type III pantothenate kinase gene gene-HME7025_01121 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01121 HME7025_01122 HME7025_01122 aguA aguA 1280024 1281073 + Agmatine deiminase Hydrolase.%3B Belongs to the agmatine deiminase family%3B KEGG: lpn:lpg0005 agmatine deiminase gene gene-HME7025_01122 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01122 HME7025_01123 HME7025_01123 HME7025_01123 1281070 1281750 + hypothetical protein gene gene-HME7025_01123 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01123 HME7025_01124 HME7025_01124 surA surA 1281899 1284094 + Peptidylprolyl isomerase Chaperone%3B Isomerase%3B Periplasm%3B Repeat%3B Rotamase%3B Signal.%3B Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains%2C which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation%3B Contains 2 PpiC domains%3B KEGG: sli:Slin_0807 peptidyl-prolyl cis-trans isomerase SurA gene gene-HME7025_01124 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01124 HME7025_01125 HME7025_01125 HME7025_01125 1284102 1285460 + Peptidylprolyl isomerase Cell membrane%3B Isomerase%3B Lipoprotein%3B Membrane%3B Palmitate%3B Rotamase%3B Signal.%3B Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Important for the secretion of the protective antigen. The three PsrA proteins in this organism show different but overlapping substrate specificities. Belongs to the PrsA family%3B Contains 1 PpiC domain%3B KEGG: cmr:Cycma_2263 peptidyl-prolyl cis-trans isomerase SurA gene gene-HME7025_01125 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01125 HME7025_01126 HME7025_01126 HME7025_01126 1285460 1286422 + uncharacterized protein ATP-binding%3B Nucleotide-binding.%3B Belongs to the MoxR family%3B KEGG: aac:Aaci_0387 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene-HME7025_01126 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01126 HME7025_01127 HME7025_01127 thyA thyA 1286510 1287304 - Thymidylate synthase Cytoplasm%3B Methyltransferase%3B Nucleotide biosynthesis%3B Transferase.%3B Provides the sole de novo source of dTMP for DNA biosynthesis%3B Belongs to the thymidylate synthase family. Bacterial- type ThyA subfamily%3B KEGG: lph:LPV_3226 thymidylate synthase gene gene-HME7025_01127 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01127 HME7025_01128 HME7025_01128 HME7025_01128 1287308 1287745 - hypothetical protein gene gene-HME7025_01128 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01128 HME7025_01129 HME7025_01129 HME7025_01129 1287747 1289087 - Alkaline phosphatase KEGG: ial:IALB_2233 alkaline phosphatase D gene gene-HME7025_01129 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01129 HME7025_01130 HME7025_01130 lysA lysA 1289132 1290373 + Diaminopimelate decarboxylase Amino-acid biosynthesis%3B Decarboxylase%3B Lyase%3B Lysine biosynthesis%3B Pyridoxal phosphate.%3B Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily%3B KEGG: evi:Echvi_1295 diaminopimelate decarboxylase gene gene-HME7025_01130 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01130 HME7025_01131 HME7025_01131 HME7025_01131 1290643 1290837 - hypothetical protein gene gene-HME7025_01131 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01131 HME7025_01132 HME7025_01132 HME7025_01132 1291105 1291404 - hypothetical protein gene gene-HME7025_01132 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01132 HME7025_01133 HME7025_01133 HME7025_01133 1291401 1291661 - Antitoxin ParD1 Antitoxin component of a toxin-antitoxin (TA) module. Neutralizes the effect of cognate toxin ParE1%2C but no other RelE or ParE toxin. May act as a DNA gyrase inhibitor (By similarity)%3B Belongs to the ParD antitoxin family gene gene-HME7025_01133 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01133 HME7025_01134 HME7025_01134 helS helS 1291883 1294894 - ATP-dependent DNA helicase Hel308 ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding.%3B DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks%3B Belongs to the helicase family. Hel308 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mif:Metin_0137 helicase%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene-HME7025_01134 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01134 HME7025_01135 HME7025_01135 HME7025_01135 1294891 1295688 - hypothetical protein gene gene-HME7025_01135 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01135 HME7025_01136 HME7025_01136 HME7025_01136 1295936 1297366 - uncharacterized protein To M. tuberculosis RV2411c%3B KEGG: fri:FraEuI1c_4782 carboxylate-amine ligase%3B Forming carbon-nitrogen bonds gene gene-HME7025_01136 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01136 HME7025_01137 HME7025_01137 mgmT mgmT 1297641 1298126 + Methylated-DNA--[protein]-cysteine S-methyltransferase DNA damage%3B DNA repair%3B DNA-binding%3B Methyltransferase%3B Nucleus%3B Transferase.%3B Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Also repairs O-4-methylthymine (By similarity)%3B Belongs to the MGMT family%3B KEGG: dru:Desru_0625 methylated-DNA-(protein)-cysteine S-methyltransferase gene gene-HME7025_01137 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01137 HME7025_01138 HME7025_01138 HME7025_01138 1298141 1299808 + DNA polymerase/3'-5' exonuclease PolX DNA damage%3B DNA repair%3B DNA replication%3B DNA synthesis%3B DNA-binding%3B DNA-directed DNA polymerase%3B Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Multifunctional enzyme%3B Nucleotidyltransferase%3B Transferase.%3B Strictly DNA-template-directed DNA polymerase%2C preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a single-nucleotide gap%2C allowing further sealing of the resulting nick by a DNA ligase%2C points to a putative role in base excision repair (BER) during the B. subtilis life cycle. Moreover%2C also possesses a 3'-5' exonuclease activity able to edit unpaired 3'-termini in a gapped DNA substrate and likely involved in resecting unannealed 3'-termini during DNA repair. The same PolX molecule could perform the subsequent gap-filling step. Does not display 5'-deoxyribose 5'-phosphate (dRP) lyase activity%2C as predicted by the lack of the lysine and tyrosine residues responsible for the dRP lyase activity in some other PolX members%3B In the N-terminal sectio%3B belongs to the DNA polymerase type-X family%3B In the C-terminal sectio%3B belongs to the PHP family gene gene-HME7025_01138 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01138 HME7025_01139 HME7025_01139 HME7025_01139 1299805 1300527 - hypothetical protein gene gene-HME7025_01139 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01139 HME7025_01140 HME7025_01140 rpiB rpiB 1300609 1301046 + Ribose-5-phosphate isomerase Isomerase.%3B Belongs to the LacAB/RpiB family%3B KEGG: yin:CH53_3042 ribose 5-phosphate isomerase B gene gene-HME7025_01140 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01140 HME7025_01141 HME7025_01141 HME7025_01141 1301043 1302413 - hypothetical protein gene gene-HME7025_01141 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01141 HME7025_01142 HME7025_01142 HME7025_01142 1302499 1302873 + Ribosome-binding factor Cytoplasm%3B rRNA processing.%3B Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA%3B Belongs to the RbfA family gene gene-HME7025_01142 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01142 HME7025_01143 HME7025_01143 HME7025_01143 1302969 1304105 + Lipoprotein-releasing system transmembrane protein LolC Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity)%3B Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily gene gene-HME7025_01143 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01143 HME7025_01144 HME7025_01144 HME7025_01144 1304095 1305333 - C4-dicarboxylate transport protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Plasmid%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene-HME7025_01144 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01144 HME7025_01145 HME7025_01145 HME7025_01145 1305339 1305785 - hypothetical protein gene gene-HME7025_01145 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01145 HME7025_01146 HME7025_01146 HME7025_01146 1305796 1306095 - hypothetical protein gene gene-HME7025_01146 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01146 HME7025_01147 HME7025_01147 HME7025_01147 1306100 1306774 - hypothetical protein gene gene-HME7025_01147 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01147 HME7025_01148 HME7025_01148 HME7025_01148 1306832 1308004 - hypothetical protein gene gene-HME7025_01148 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01148 HME7025_01149 HME7025_01149 HME7025_01149 1308100 1308588 + Isoquinoline 1-oxidoreductase 2Fe-2S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase.%3B Specific towards N-containing N-heterocyclic substrates%2C including isoquinoline%2C isoquinolin-5-ol%2C phthalazine and quinazoline. Contains 1 2Fe-2S ferredoxin-type domain%3B KEGG: sli:Slin_6243 isoquinoline 1-oxidoreductase%2C alpha subunit gene gene-HME7025_01149 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01149 HME7025_01150 HME7025_01150 HME7025_01150 1308585 1310765 + Isoquinoline 1-oxidoreductase Aromatic hydrocarbons catabolism%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Molybdenum%3B Oxidoreductase%3B Repeat%3B Transmembrane%3B Transmembrane helix.%3B Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation%2C the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA)%3B Contains 3 cytochrome c domains%3B KEGG: doi:FH5T_21155 isoquinoline 1-oxidoreductase%2C beta subunit gene gene-HME7025_01150 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01150 HME7025_01151 HME7025_01151 mocA mocA 1310765 1311346 + Molybdenum cofactor cytidylyltransferase KEGG: gme:Gmet_2140 molybdenum cofactor cytidylyltransferase gene gene-HME7025_01151 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01151 HME7025_01152 HME7025_01152 HME7025_01152 1311418 1313685 + Phosphoribosylformylglycinamidine synthase ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Purine biosynthesis.%3B Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Belongs to the FGAMS family%3B KEGG: srd:SD10_12720 phosphoribosylformylglycinamidine synthase gene gene-HME7025_01152 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01152 HME7025_01153 HME7025_01153 truA truA 1313698 1314465 + tRNA pseudouridine(38-40) synthase Isomerase%3B tRNA processing.%3B Formation of pseudouridine at positions 38%2C 39 and 40 in the anticodon stem and loop of transfer RNAs%3B Belongs to the tRNA pseudouridine synthase TruA family%3B KEGG: sha:SH0834 tRNA pseudouridine38-40 synthase gene gene-HME7025_01153 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01153 HME7025_01154 HME7025_01154 HME7025_01154 1314437 1315816 - DNA repair protein RadA like protein ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Metal-binding%3B Nucleotide-binding%3B Zinc%3B Zinc-finger.%3B May play a role in the repair of endogenous alkylation damage%3B Belongs to the RecA family. RadA subfamily gene gene-HME7025_01154 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01154 HME7025_01155 HME7025_01155 HME7025_01155 1315921 1316601 + hypothetical protein gene gene-HME7025_01155 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01155 HME7025_01156 HME7025_01156 pheS pheS 1316617 1317642 + Phenylalanine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis.%3B Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily%3B KEGG: aas:Aasi_0475 phenylalanyl-tRNA synthetase alpha chain gene gene-HME7025_01156 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01156 HME7025_01157 HME7025_01157 HME7025_01157 1317711 1320689 + hypothetical protein gene gene-HME7025_01157 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01157 HME7025_01158 HME7025_01158 HME7025_01158 1320775 1321932 - Chaperone protein DnaJ Chaperone%3B Cytoplasm%3B DNA replication%3B Metal-binding%3B Repeat%3B Stress response%3B Zinc%3B Zinc-finger.%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C DnaK-independent fashion. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding. Also involved%2C together with DnaK and GrpE%2C in the DNA replication of plasmids through activation of initiation proteins%3B Belongs to the DnaJ family%3B Contains 1 CR-type zinc finger%3B Contains 1 J domain gene gene-HME7025_01158 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01158 HME7025_01159 HME7025_01159 HME7025_01159 1321941 1322465 - Protein GrpE Chaperone%3B Cytoplasm%3B Stress response.%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins%2C in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding%3B Belongs to the GrpE family gene gene-HME7025_01159 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01159 HME7025_01160 HME7025_01160 queG queG 1322566 1323507 + Epoxyqueuosine reductase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Queuosine biosynthesis%3B Repeat%3B tRNA processing.%3B Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q)%2C which is a hypermodified base found in the wobble positions of tRNA(Asp)%2C tRNA(Asn)%2C tRNA(His) and tRNA(Tyr)%3B Belongs to the QueG family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: sli:Slin_1519 epoxyqueuosine reductase gene gene-HME7025_01160 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01160 HME7025_01161 HME7025_01161 HME7025_01161 1323539 1324567 - Arabinose metabolism transcriptional repressor Cytoplasm%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation.%3B Transcriptional repressor of the arabinose utilization genes%3B Contains 1 HTH gntR-type DNA-binding domain gene gene-HME7025_01161 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01161 HME7025_01162 HME7025_01162 HME7025_01162 1324870 1328970 + Hybrid signal transduction histidine kinase ATP-binding%3B Coiled coil%3B Kinase%3B Nucleotide-binding%3B Phosphoprotein%3B Repeat%3B Transducer%3B Transferase%3B Two-component regulatory system.%3B Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Contains 2 histidine kinase domains%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 2 response regulatory domains%3B KEGG: gfo:GFO_0036 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene-HME7025_01162 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01162 HME7025_01163 HME7025_01163 HME7025_01163 1328957 1329961 + hypothetical protein gene gene-HME7025_01163 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01163 HME7025_01164 HME7025_01164 HME7025_01164 1329963 1330493 + hypothetical protein gene gene-HME7025_01164 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01164 HME7025_01165 HME7025_01165 HME7025_01165 1330724 1331590 - HTH-type transcriptional activator Btr Activator%3B Cytoplasm%3B DNA-binding%3B Transcription%3B Transcription regulation.%3B In iron-limited conditions%2C activates expression of the feuABCybbA operon%2C which encodes the bacillibactin uptake system. Acts by binding directly to a conserved direct repeat element upstream of the feuA promoter. Activity is increased in the presence of bacillibactin%3B Contains 1 Fe/B12 periplasmic-binding domain%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene-HME7025_01165 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01165 HME7025_01166 HME7025_01166 acp5 acp5 1331779 1332711 - Acid phosphatase Glycoprotein%3B Hydrolase%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Secreted%3B Signal%3B Zinc.%3B Metallo-phosphoesterase involved in phosphate metabolism. Has a peroxidase activity%3B Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family%3B KEGG: pvu:PHAVU_002G332100g tartrate-resistant acid phosphatase type 5 gene gene-HME7025_01166 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01166 HME7025_01167 HME7025_01167 mnmA mnmA 1332708 1333886 - tRNA-specific 2-thiouridylase MnmA ATP-binding%3B Cytoplasm%3B Disulfide bond%3B Nucleotide-binding%3B RNA-binding%3B Transferase%3B tRNA processing%3B tRNA-binding.%3B Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA%2C leading to the formation of s(2)U34%3B Belongs to the MnmA/TRMU family%3B KEGG: lpk:LACPI_0876 tRNA-specific 2-thiouridylase%3B Sulfurtransferases gene gene-HME7025_01167 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01167 HME7025_01168 HME7025_01168 HME7025_01168 1333949 1334566 + Phosphoribosylanthranilate isomerase KEGG: cmr:Cycma_4256 phosphoribosylanthranilate isomerase gene gene-HME7025_01168 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01168 HME7025_01169 HME7025_01169 HME7025_01169 1334579 1337191 + Monofunctional biosynthetic peptidoglycan transglycosylase Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Peptidoglycan synthesis%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Cell wall formation%3B Belongs to the glycosyltransferase 51 family%3B KEGG: rsi:Runsl_4367 penicillin-binding protein 1A%3B Hexosyltransferases gene gene-HME7025_01169 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01169 HME7025_01170 HME7025_01170 cpoX cpoX 1337194 1338087 + Coproporphyrinogen oxidase Cytoplasm%3B Heme biosynthesis%3B Metal-binding%3B Oxidoreductase%3B Porphyrin biosynthesis.%3B Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX%3B Belongs to the aerobic coproporphyrinogen-III oxidase family%3B KEGG: scn:Solca_1436 coproporphyrinogen III oxidase gene gene-HME7025_01170 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01170 HME7025_01171 HME7025_01171 HME7025_01171 1338180 1338581 - hypothetical protein gene gene-HME7025_01171 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01171 HME7025_01172 HME7025_01172 menC menC 1338630 1339724 - o-succinylbenzoate synthase KEGG: dps:DP0251 O-succinylbenzoate synthase gene gene-HME7025_01172 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01172 HME7025_01173 HME7025_01173 lpxK lpxK 1339792 1340799 + Tetraacyldisaccharide 4'-kinase ATP-binding%3B Kinase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Nucleotide-binding%3B Transferase.%3B Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1%2C4'-bis-phosphate (lipid IVA)%3B Belongs to the LpxK family%3B KEGG: pcu:pc1786 tetraacyldisaccharide 4'-kinase gene gene-HME7025_01173 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01173 HME7025_01174 HME7025_01174 HME7025_01174 1340829 1342820 + hypothetical protein gene gene-HME7025_01174 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01174 HME7025_01175 HME7025_01175 HME7025_01175 1343052 1343678 + uncharacterized protein gene gene-HME7025_01175 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01175 HME7025_01176 HME7025_01176 HME7025_01176 1343788 1344327 + hypothetical protein gene gene-HME7025_01176 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01176 HME7025_01177 HME7025_01177 HME7025_01177 1344338 1346047 + Gluconate 2-dehydrogenase (acceptor) Cell membrane%3B FAD%3B Flavoprotein%3B Membrane%3B Oxidoreductase.%3B Catalytic subunit of fructose dehydrogenase%2C an enzyme that catalyzes the oxidation of D-fructose to produce 5-keto-D- fructose%3B Belongs to the GMC oxidoreductase family%3B KEGG: bif:N288_03430 gluconate 2-dehydrogenase alpha chain gene gene-HME7025_01177 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01177 HME7025_01178 HME7025_01178 HME7025_01178 1346054 1348972 + hypothetical protein gene gene-HME7025_01178 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01178 HME7025_01179 HME7025_01179 scp2 scp2 1349038 1349322 + Propanoyl-CoA C-acyltransferase Acetylation%3B Alternative splicing%3B NADP%3B Oxidoreductase%3B Peroxisome.%3B Has apparently no steroid dehydrogenase activity%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B Contains 1 SCP2 domain%3B KEGG: mze:101474585 sterol carrier protein 2 gene gene-HME7025_01179 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01179 HME7025_01180 HME7025_01180 mnmE mnmE 1349322 1350686 + tRNA modification GTPase MnmE Cytoplasm%3B GTP-binding%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Potassium%3B tRNA processing.%3B Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA- cmnm(5)s(2)U34%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. TrmE GTPase family%3B Contains 1 TrmE-type G (guanine nucleotide-binding) domain%3B KEGG: mtt:Ftrac_1499 tRNA modification GTPase%3B Acting on acid anhydrides gene gene-HME7025_01180 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01180 HME7025_01181 HME7025_01181 HME7025_01181 1350924 1351475 + hypothetical protein gene gene-HME7025_01181 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01181 HME7025_01182 HME7025_01182 HME7025_01182 1351496 1352638 + Tyrosine recombinase XerD Cell cycle%3B Cell division%3B Chromosome partition%3B Cytoplasm%3B DNA integration%3B DNA recombination%3B DNA-binding.%3B Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerD subfamily gene gene-HME7025_01182 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01182 HME7025_01183 HME7025_01183 HME7025_01183 1352661 1353938 + hypothetical protein gene gene-HME7025_01183 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01183 HME7025_01184 HME7025_01184 HME7025_01184 1353983 1354339 + hypothetical protein gene gene-HME7025_01184 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01184 HME7025_01185 HME7025_01185 HME7025_01185 1354332 1354622 + hypothetical protein gene gene-HME7025_01185 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01185 HME7025_01186 HME7025_01186 HME7025_01186 1354564 1355829 + hypothetical protein gene gene-HME7025_01186 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01186 HME7025_01187 HME7025_01187 hsdR hsdR 1355950 1357218 + Type I site-specific deoxyribonuclease KEGG: pbt:ING2E5B_0632 type I restriction enzyme%2C R subunit gene gene-HME7025_01187 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01187 HME7025_01188 HME7025_01188 HME7025_01188 1357220 1357426 + hypothetical protein gene gene-HME7025_01188 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01188 HME7025_01189 HME7025_01189 HME7025_01189 1357475 1358059 + hypothetical protein gene gene-HME7025_01189 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01189 HME7025_01190 HME7025_01190 HME7025_01190 1358065 1359078 - hypothetical protein gene gene-HME7025_01190 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01190 HME7025_01191 HME7025_01191 HME7025_01191 1359343 1359924 - hypothetical protein gene gene-HME7025_01191 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01191 HME7025_01192 HME7025_01192 HME7025_01192 1359990 1360364 - hypothetical protein gene gene-HME7025_01192 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01192 HME7025_01193 HME7025_01193 HME7025_01193 1360601 1363708 - Multidrug resistance protein MdtB Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtB subfamily gene gene-HME7025_01193 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01193 HME7025_01194 HME7025_01194 HME7025_01194 1363720 1364775 - uncharacterized protein Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene-HME7025_01194 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01194 HME7025_01195 HME7025_01195 HME7025_01195 1364800 1366125 - hypothetical protein gene gene-HME7025_01195 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01195 HME7025_01196 HME7025_01196 HME7025_01196 1366145 1366732 - Nucleoid occlusion factor SlmA Cell cycle%3B Cell division%3B Cytoplasm%3B DNA-binding.%3B Required for nucleoid occlusion (NO) phenomenon%2C which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ%2C and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome%2C preventing FtsZ polymerization at these regions%3B Belongs to the nucleoid occlusion factor SlmA family%3B Contains 1 HTH tetR-type DNA-binding domain gene gene-HME7025_01196 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01196 HME7025_01197 HME7025_01197 ligA ligA 1367269 1368297 + DNA ligase (NAD(+)) KEGG: rmc:RMONA_03735 DNA ligase (NAD+) gene gene-HME7025_01197 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01197 HME7025_01198 HME7025_01198 HME7025_01198 1368349 1368783 + hypothetical protein gene gene-HME7025_01198 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01198 HME7025_01199 HME7025_01199 crtA crtA 1368824 1369498 + Spheroidene monooxygenase Carotenoid biosynthesis%3B Chlorophyll biosynthesis%3B Oxidoreductase%3B Photosynthesis.%3B Catalyzes the asymmetrical introduction of one keto group at the C-2 position of spheroidene and two keto groups at the C-2 and C-2' positions of spirilloxanthin%3B KEGG: rsp:RSP_0272 spheroidene monooxygenase gene gene-HME7025_01199 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01199 HME7025_01200 HME7025_01200 HME7025_01200 1369624 1369965 - Nitrogen regulatory protein P-II Nucleotide-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation.%3B In nitrogen-limiting conditions%2C when the ratio of Gln to 2-ketoglutarate decreases%2C P-II is uridylylated to P-II-UMP. P- II-UMP allows the deadenylation of glutamine synthetase (GS)%2C thus activating the enzyme. Conversely%2C in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate%2C the transcriptional activator of glnA. When P-II is uridylylated to P- II-UMP%2C these events are reversed (By similarity)%3B Belongs to the P(II) protein family gene gene-HME7025_01200 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01200 HME7025_01201 HME7025_01201 HME7025_01201 1369984 1371225 - Ammonium transporter Ammonia transport%3B Cell membrane%3B Cytoplasmic vesicle%3B Endosome%3B Lysosome%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Vacuole.%3B Ammonium transporter that mediates the excretion of ammonium from the prestalk cells from the slug. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development%3B Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene-HME7025_01201 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01201 HME7025_01202 HME7025_01202 HME7025_01202 1371348 1373270 + Beta-N-acetylhexosaminidase Carbohydrate metabolism%3B Chitin degradation%3B Disulfide bond%3B Glycosidase%3B Hydrolase%3B Periplasm%3B Polysaccharide degradation%3B Signal.%3B Digests the beta-1%2C4-glycosidic bonds in N- acetylglucosamine (GlcNAc) oligomers (mainly dimers). Belongs to the glycosyl hydrolase 20 family%3B KEGG: sfi:SFUL_2381 hexosaminidase gene gene-HME7025_01202 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01202 HME7025_01203 HME7025_01203 HME7025_01203 1373275 1374051 + hypothetical protein gene gene-HME7025_01203 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01203 HME7025_01204 HME7025_01204 HME7025_01204 1374061 1374714 + Nuclease Endonuclease%3B Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nuclease%3B Periplasm%3B Plasmid%3B Signal.%3B Catalyzes the degradation of both RNA and DN%3B has the potential to act as an endonuclease. Belongs to the DNA/RNA non-specific endonuclease family gene gene-HME7025_01204 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01204 HME7025_01205 HME7025_01205 HME7025_01205 1374711 1376606 - Unsaturated rhamnogalacturonyl hydrolase Cytoplasm%3B Glycosidase%3B Hydrolase.%3B Catalyzes the hydrolysis of unsaturated rhamnogalacturonan disaccharide to yield unsaturated D- galacturonic acid and L-rhamnose. It cannot act on unsaturated glucuronyl hydrolase (UGL) substrates containing unsaturated D- glucuronic acid at the non-reducing terminus%2C although the active pockets of YesR and UGL are very similar%3B Belongs to the glycosyl hydrolase 105 family%3B KEGG: hhy:Halhy_4395 unsaturated rhamnogalacturonyl hydrolase gene gene-HME7025_01205 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01205 HME7025_01206 HME7025_01206 kduI kduI 1376609 1377439 - 5-dehydro-4-deoxy-D-glucuronate isomerase Isomerase%3B Metal-binding%3B Zinc.%3B Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2%2C5-hexodiulosonate%3B Belongs to the KduI family%3B KEGG: dfe:Dfer_2839 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase gene gene-HME7025_01206 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01206 HME7025_01207 HME7025_01207 HME7025_01207 1377465 1378376 + hypothetical protein gene gene-HME7025_01207 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01207 HME7025_01208 HME7025_01208 miaA miaA 1378422 1379228 + tRNA dimethylallyltransferase ATP-binding%3B Magnesium%3B Nucleotide-binding%3B Transferase%3B tRNA processing.%3B Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine%2C leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)%3B Belongs to the IPP transferase family%3B KEGG: aci:ACIAD2374 tRNA dimethylallyltransferase gene gene-HME7025_01208 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01208 HME7025_01209 HME7025_01209 HME7025_01209 1379250 1379337 + tRNA-Ser tRNA gene-HME7025_01209 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01209 HME7025_01210 HME7025_01210 rsmI rsmI 1379524 1380195 + 16S rRNA (cytidine(1402)-2'-O)-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmI family%3B KEGG: son:SO_0301 16S rRNA (cytidine1402-2'-O)-methyltransferase gene gene-HME7025_01210 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01210 HME7025_01211 HME7025_01211 HME7025_01211 1380202 1381350 + hypothetical protein gene gene-HME7025_01211 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01211 HME7025_01212 HME7025_01212 ltaE ltaE 1381355 1382371 + L-threonine aldolase Lyase%3B Pyridoxal phosphate.%3B Stereospecifically catalyzes the interconversion of L- allo-threonine and glycine. Belongs to the threonine aldolase family%3B KEGG: fau:Fraau_2408 threonine aldolase gene gene-HME7025_01212 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01212 HME7025_01213 HME7025_01213 HME7025_01213 1382458 1382772 + L-rhamnose mutarotase Carbohydrate metabolism%3B Cytoplasm%3B Isomerase%3B Rhamnose metabolism.%3B Involved in the anomeric conversion of L-rhamnose%3B Belongs to the rhamnose mutarotase family%3B KEGG: emu:EMQU_2086 L-rhamnose mutarotase gene gene-HME7025_01213 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01213 HME7025_01214 HME7025_01214 HME7025_01214 1382782 1383906 + Unsaturated rhamnogalacturonyl hydrolase KEGG: hdl:HALDL1_04890 unsaturated rhamnogalacturonyl hydrolase gene gene-HME7025_01214 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01214 HME7025_01215 HME7025_01215 HME7025_01215 1383961 1384512 + hypothetical protein gene gene-HME7025_01215 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01215 HME7025_01216 HME7025_01216 HME7025_01216 1384599 1385513 - hypothetical protein gene gene-HME7025_01216 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01216 HME7025_01217 HME7025_01217 HME7025_01217 1385699 1385833 + hypothetical protein gene gene-HME7025_01217 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01217 HME7025_01218 HME7025_01218 HME7025_01218 1385878 1386489 + hypothetical protein gene gene-HME7025_01218 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01218 HME7025_01219 HME7025_01219 HME7025_01219 1386494 1386904 + Protein disulfide-isomerase Disulfide bond%3B Oxidoreductase%3B Periplasm%3B Redox-active center%3B Signal.%3B Catalyzes the reduction of disulfide bonds. May function in reducing intermolecular disulfides between proteins and small molecules in the periplasm%2C or keeping a specific subset of periplasmic proteins reduced%2C or maintaining the periplasm of Chlamydia in a generally reducing state. Seems to be unable to oxidize thiols into disulfides and does not display disulfide bond isomerase activity%3B Contains 1 thioredoxin domain%3B KEGG: fps:FP2335 protein disulfide-isomerase gene gene-HME7025_01219 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01219 HME7025_01220 HME7025_01220 HME7025_01220 1386909 1387850 + FAD:protein FMN transferase Cell membrane%3B FAD%3B Flavoprotein%3B Magnesium%3B Membrane%3B Metal-binding%3B Nitrogen fixation%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein (By similarity). Is likely involved in the modification of RnfG and RnfD. Required for nitrogen fixation (PubMed:8264535)%3B In the N-terminal sectio%3B belongs to the RseC family%3B In the C-terminal sectio%3B belongs to the ApbE family gene gene-HME7025_01220 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01220 HME7025_01221 HME7025_01221 HME7025_01221 1387860 1388072 + hypothetical protein gene gene-HME7025_01221 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01221 HME7025_01222 HME7025_01222 HME7025_01222 1388082 1389332 + hypothetical protein gene gene-HME7025_01222 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01222 HME7025_01223 HME7025_01223 HME7025_01223 1389773 1390246 - Leucine-responsive regulatory protein Activator%3B DNA-binding%3B Transcription%3B Transcription regulation.%3B Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operon%3B lrp mediates this effect for at least some of these operons (By similarity)%3B Contains 1 HTH asnC-type DNA-binding domain gene gene-HME7025_01223 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01223 HME7025_01224 HME7025_01224 HME7025_01224 1390304 1390441 + hypothetical protein gene gene-HME7025_01224 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01224 HME7025_01225 HME7025_01225 HME7025_01225 1390462 1391547 + NAD(P)(+) transhydrogenase (Re/Si-specific) NAD%3B Oxidoreductase.%3B May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer%3B Belongs to the AlaDH/PNT family%3B KEGG: serr:Ser39006_2809 NAD(P) transhydrogenase subunit alpha gene gene-HME7025_01225 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01225 HME7025_01226 HME7025_01226 HME7025_01226 1391548 1392849 - hypothetical protein gene gene-HME7025_01226 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01226 HME7025_01227 HME7025_01227 HME7025_01227 1392854 1394437 - putative actinorhodin transporter Antibiotic resistance%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Promotes the efflux of actinorhodin. Belongs to the major facilitator superfamily. EmrB family gene gene-HME7025_01227 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01227 HME7025_01228 HME7025_01228 HME7025_01228 1394442 1395479 - UPF0194 membrane protein in asrC 5'region Coiled coil%3B Periplasm%3B Signal.%3B Belongs to the UPF0194 family gene gene-HME7025_01228 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01228 HME7025_01229 HME7025_01229 HME7025_01229 1395584 1396084 + hypothetical protein gene gene-HME7025_01229 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01229 HME7025_01230 HME7025_01230 HME7025_01230 1396086 1397519 - Exodeoxyribonuclease V KEGG: cmr:Cycma_0951 exodeoxyribonuclease V gene gene-HME7025_01230 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01230 HME7025_01231 HME7025_01231 pabC pabC 1397539 1398138 - Aminodeoxychorismate lyase KEGG: apa:APP7_1203 4-amino-4-deoxychorismate lyase gene gene-HME7025_01231 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01231 HME7025_01232 HME7025_01232 pabB pabB 1398142 1399116 - Aminodeoxychorismate synthase To the C-terminal of para-aminobenzoate synthase component I%3B KEGG: bvu:BVU_2233 para-aminobenzoate synthetase component I gene gene-HME7025_01232 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01232 HME7025_01233 HME7025_01233 aarS aarS 1399125 1401761 - Alanine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B RNA-binding%3B tRNA-binding%3B Zinc.%3B Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: lpn:lpg1799 alanyl-tRNA synthetase gene gene-HME7025_01233 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01233 HME7025_01234 HME7025_01234 HME7025_01234 1401888 1402217 + hypothetical protein gene gene-HME7025_01234 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01234 HME7025_01235 HME7025_01235 HME7025_01235 1402254 1403354 + Protein smf Essential for efficient chromosomal DNA transformation but not required for plasmid transformation%3B Belongs to the smf family gene gene-HME7025_01235 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01235 HME7025_01236 HME7025_01236 pyrE pyrE 1403356 1403994 - Orotate phosphoribosyltransferase Glycosyltransferase%3B Magnesium%3B Pyrimidine biosynthesis%3B Transferase.%3B Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate%2C leading to the formation of orotidine monophosphate (OMP)%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily%3B KEGG: apc:HIMB59_00009810 orotate phosphoribosyltransferase gene gene-HME7025_01236 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01236 HME7025_01237 HME7025_01237 ndx1 ndx1 1404095 1404790 + Diadenosine hexaphosphate hydrolase (ATP-forming) KEGG: dmr:Deima_2556 diadenosine hexaphosphate hydrolase (ATP-forming) gene gene-HME7025_01237 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01237 HME7025_01238 HME7025_01238 coaD coaD 1404760 1405230 - Pantetheine-phosphate adenylyltransferase ATP-binding%3B Coenzyme A biosynthesis%3B Cytoplasm%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine%2C yielding dephospho-CoA (dPCoA) and pyrophosphate%3B Belongs to the bacterial CoaD family%3B KEGG: mes:Meso_1402 pantetheine-phosphate adenylyltransferase gene gene-HME7025_01238 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01238 HME7025_01239 HME7025_01239 HME7025_01239 1405220 1406011 - hypothetical protein gene gene-HME7025_01239 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01239 HME7025_01240 HME7025_01240 HME7025_01240 1406049 1407662 + Phosphonates import ATP-binding protein PhnC ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Phosphonate transport%3B Transport.%3B Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain gene gene-HME7025_01240 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01240 HME7025_01241 HME7025_01241 HME7025_01241 1407854 1409245 - Inositol 2-dehydrogenase NAD%3B Oxidoreductase.%3B Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: wic:J056_003487 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_01241 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01241 HME7025_01242 HME7025_01242 gapN gapN 1409352 1410974 - Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) Cytoplasm%3B NADP%3B Oxidoreductase%3B Stress response.%3B Important as a means of generating NADPH for biosynthetic reactions. May be a main source of cytosolic NADPH for mannitol biosynthesis in leaves%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: dar:Daro_2068 glyceraldehyde-3-phosphate dehydrogenase (NADP+) gene gene-HME7025_01242 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01242 HME7025_01243 HME7025_01243 HME7025_01243 1411092 1411283 - hypothetical protein gene gene-HME7025_01243 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01243 HME7025_01244 HME7025_01244 HME7025_01244 1411273 1412457 - putative MFS-type transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the major facilitator superfamily. TCR/Tet family gene gene-HME7025_01244 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01244 HME7025_01245 HME7025_01245 HME7025_01245 1412459 1414831 - hypothetical protein gene gene-HME7025_01245 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01245 HME7025_01246 HME7025_01246 ispD ispD 1414834 1415523 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Isoprene biosynthesis%3B Nucleotidyltransferase%3B Transferase.%3B Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)%3B Belongs to the IspD family%3B KEGG: doi:FH5T_08865 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase gene gene-HME7025_01246 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01246 HME7025_01247 HME7025_01247 HME7025_01247 1415541 1416593 - S-adenosylmethionine:tRNA ribosyltransferase-isomerase Cytoplasm%3B Queuosine biosynthesis%3B S-adenosyl-L-methionine%3B Transferase.%3B Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)%3B Belongs to the QueA family%3B KEGG: pmr:PMI0075 S-adenosylmethionine:tRNA ribosyltransferase-isomerase gene gene-HME7025_01247 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01247 HME7025_01248 HME7025_01248 HME7025_01248 1416777 1418072 + Deoxyribodipyrimidine photo-lyase Contains 1 photolyase/cryptochrome alpha/beta domain%3B KEGG: bmx:BMS_2619 deoxyribodipyrimidine photo-lyase gene gene-HME7025_01248 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01248 HME7025_01249 HME7025_01249 HME7025_01249 1418064 1418852 - hypothetical protein gene gene-HME7025_01249 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01249 HME7025_01250 HME7025_01250 HME7025_01250 1419016 1420077 + Protein RecA ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Nucleotide-binding%3B SOS response.%3B It interacts with LexA causing its activation and leading to its autocatalytic cleavage%3B Belongs to the RecA family gene gene-HME7025_01250 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01250 HME7025_01251 HME7025_01251 HME7025_01251 1420129 1421547 - Chromosomal replication initiator protein DnaA ATP-binding%3B Cytoplasm%3B DNA replication%3B DNA-binding%3B Nucleotide-binding.%3B Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replicatio%3B it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids%3B Belongs to the DnaA family gene gene-HME7025_01251 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01251 HME7025_01252 HME7025_01252 HME7025_01252 1421636 1421764 + hypothetical protein gene gene-HME7025_01252 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01252 HME7025_01253 HME7025_01253 dagK dagK 1421978 1422829 - Diacylglycerol kinase (ATP) In the N-terminal sectio%3B belongs to the methylglyoxal synthase family%3B Contains 1 DAGKc domain%3B KEGG: req:REQ_19630 diacylglycerol kinase (ATP) gene gene-HME7025_01253 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01253 HME7025_01254 HME7025_01254 phaJ phaJ 1422893 1423297 + 3-hydroxybutyryl-CoA dehydratase Fatty acid metabolism%3B Lipid metabolism%3B Lyase.%3B Catalyzes the hydration of trans-2-enoyl-CoA with a chain-length of 4-6 carbon atoms%2C forming the corresponding (3R)- 3-hydroxyacyl-CoA%3B Contains 1 MaoC-like domain%3B KEGG: ccr:CC_0704 3-hydroxybutyryl-CoA dehydratase gene gene-HME7025_01254 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01254 HME7025_01255 HME7025_01255 HME7025_01255 1423354 1423533 - hypothetical protein gene gene-HME7025_01255 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01255 HME7025_01256 HME7025_01256 HME7025_01256 1423690 1424913 - Glycine C-acetyltransferase Biotin biosynthesis%3B Pyridoxal phosphate%3B Transferase.%3B Catalyzes the decarboxylative condensation of pimeloyl- [acyl-carrier protein] and L-alanine to produce 8-amino-7- oxononanoate (AON)%2C [acyl-carrier protein]%2C and carbon dioxide%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily%3B KEGG: lby:Lbys_3455 glycine C-acetyltransferase gene gene-HME7025_01256 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01256 HME7025_01257 HME7025_01257 HME7025_01257 1425067 1426758 + Gamma-glutamyltransferase Acyltransferase%3B Antibiotic resistance%3B Hydrolase%3B Transferase%3B Zymogen.%3B Besides the cephalosporin acylase I activity which converts GL-7ACA into 7-AC%3B this enzyme displays some gamma glutamyltranspeptidase activity. Belongs to the gamma-glutamyltransferase family%3B KEGG: aqu:100636109 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase gene gene-HME7025_01257 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01257 HME7025_01258 HME7025_01258 HME7025_01258 1426755 1427453 - Vacuolar iron transporter 1.1 Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Vacuole.%3B Probable vacuolar iron transporter that may be involved in the transfer of iron from the cytosol to the vacuole for intracellular iron storage%3B Belongs to the CCC1 family gene gene-HME7025_01258 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01258 HME7025_01259 HME7025_01259 HME7025_01259 1427458 1429047 - Dipeptide permease Cell inner membrane%3B Cell membrane%3B Membrane%3B Peptide transport%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Probable proton-dependent permease that transports dipeptides%3B Belongs to the PTR2/POT transporter (TC 2. A. 17) family. DtpD subfamily gene gene-HME7025_01259 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01259 HME7025_01260 HME7025_01260 HME7025_01260 1429211 1429990 + Sporulation initiation inhibitor protein Soj ATP-binding%3B Hydrolase%3B Nucleotide-binding%3B Sporulation.%3B Inhibits the initiation of sporulation%2C Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. It is not required for chromosome partitioning (By similarity)%3B Belongs to the ParA family gene gene-HME7025_01260 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01260 HME7025_01261 HME7025_01261 HME7025_01261 1430004 1430924 + Nucleoid occlusion protein Cell cycle%3B Cell division%3B Cytoplasm%3B DNA-binding%3B Septation.%3B Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid%2C especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid%2C which would cause chromosome breakage%3B Belongs to the ParB family gene gene-HME7025_01261 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01261 HME7025_01262 HME7025_01262 HME7025_01262 1430932 1431591 + hypothetical protein gene gene-HME7025_01262 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01262 HME7025_01263 HME7025_01263 dapB dapB 1431596 1432315 + 4-hydroxy-tetrahydrodipicolinate reductase Amino-acid biosynthesis%3B Cytoplasm%3B Diaminopimelate biosynthesis%3B Lysine biosynthesis%3B NAD%3B NADP%3B Oxidoreductase.%3B Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate%3B Belongs to the DapB family%3B KEGG: pgi:PG2002 4-hydroxy-tetrahydrodipicolinate reductase gene gene-HME7025_01263 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01263 HME7025_01264 HME7025_01264 HME7025_01264 1432317 1433099 + hypothetical protein gene gene-HME7025_01264 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01264 HME7025_01265 HME7025_01265 lepB lepB 1433101 1434246 + Signal peptidase I Cell membrane%3B Hydrolase%3B Membrane%3B Protease%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the peptidase S26 family%3B KEGG: cpi:Cpin_6436 signal peptidase I gene gene-HME7025_01265 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01265 HME7025_01266 HME7025_01266 rlmI rlmI 1434302 1435483 - 23S rRNA (cytosine(1962)-C(5))-methyltransferase Cytoplasm%3B Methyltransferase%3B RNA-binding%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase.%3B Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmKL family%3B Contains 1 THUMP domain%3B KEGG: lbi:LEPBI_I1819 23S rRNA (cytosine1962-C5)-methyltransferase gene gene-HME7025_01266 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01266 HME7025_01267 HME7025_01267 HME7025_01267 1435503 1436399 - hypothetical protein gene gene-HME7025_01267 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01267 HME7025_01268 HME7025_01268 HME7025_01268 1436454 1436711 + 30S ribosomal protein S20 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds directly to 16S ribosomal RNA%3B Belongs to the ribosomal protein S20P family gene gene-HME7025_01268 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01268 HME7025_01269 HME7025_01269 HME7025_01269 1436747 1437499 + UPF0758 protein Belongs to the UPF0758 family gene gene-HME7025_01269 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01269 HME7025_01270 HME7025_01270 HME7025_01270 1437510 1437608 - hypothetical protein gene gene-HME7025_01270 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01270 HME7025_01271 HME7025_01271 hisB hisB 1437647 1438759 - Imidazoleglycerol-phosphate dehydratase Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Hydrolase%3B Lyase%3B Multifunctional enzyme.%3B In the N-terminal sectio%3B belongs to the histidinol- phosphatase family%3B In the C-terminal sectio%3B belongs to the imidazoleglycerol-phosphate dehydratase family%3B KEGG: osp:Odosp_2100 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase gene gene-HME7025_01271 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01271 HME7025_01272 HME7025_01272 HME7025_01272 1438880 1440130 + hypothetical protein gene gene-HME7025_01272 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01272 HME7025_01273 HME7025_01273 rrp3 rrp3 1440270 1442099 + RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Nucleus%3B Ribosome biogenesis%3B RNA-binding%3B rRNA processing.%3B ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0%2C A1%2C and A2%2C leading to mature 18S rRNA. Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: atr:18433650 ATP-dependent RNA helicase DDX47/RRP3 gene gene-HME7025_01273 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01273 HME7025_01274 HME7025_01274 HME7025_01274 1442150 1442596 - hypothetical protein gene gene-HME7025_01274 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01274 HME7025_01275 HME7025_01275 HME7025_01275 1442596 1442982 - Protein ApaG Contains 1 apaG domain gene gene-HME7025_01275 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01275 HME7025_01276 HME7025_01276 HME7025_01276 1442987 1443691 + Uracil-DNA glycosylase Cytoplasm%3B DNA damage%3B DNA repair%3B Glycosidase%3B Hydrolase.%3B Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine%3B Belongs to the uracil-DNA glycosylase family%3B KEGG: vma:VAB18032_00785 uracil-DNA glycosylase gene gene-HME7025_01276 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01276 HME7025_01277 HME7025_01277 HME7025_01277 1443686 1443982 - hypothetical protein gene gene-HME7025_01277 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01277 HME7025_01278 HME7025_01278 HME7025_01278 1443979 1446939 - uncharacterized protein Contains 1 4Fe-4S ferredoxin-type domain%3B Contains 1 FAD-binding PCMH-type domain%3B To H. influenzae HI_1163%3B To mammalian alkyldihydroxyacetonephosphate synthases%2C to yeast AIP2 and DLD1 and to E. coli YgcU gene gene-HME7025_01278 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01278 HME7025_01279 HME7025_01279 HME7025_01279 1447086 1448330 + Macrolide export ATP-binding/permease protein MacB Antibiotic resistance%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain gene gene-HME7025_01279 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01279 HME7025_01280 HME7025_01280 HME7025_01280 1448378 1449313 - Malate dehydrogenase NAD%3B Oxidoreductase%3B Tricarboxylic acid cycle.%3B Catalyzes the reversible oxidation of malate to oxaloacetate%3B Belongs to the LDH/MDH superfamily. MDH type 3 family%3B KEGG: cje:Cj0532 malate dehydrogenase gene gene-HME7025_01280 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01280 HME7025_01281 HME7025_01281 HME7025_01281 1449470 1449889 + hypothetical protein gene gene-HME7025_01281 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01281 HME7025_01282 HME7025_01282 HME7025_01282 1449961 1450167 + Sec-independent protein translocase protein TatA Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system%3B Belongs to the TatA/E family gene gene-HME7025_01282 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01282 HME7025_01283 HME7025_01283 HME7025_01283 1450213 1451661 + Asparaginyl-tRNA synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)%3B Belongs to the amidase family. GatA subfamily%3B KEGG: dly:Dehly_1039 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A gene gene-HME7025_01283 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01283 HME7025_01284 HME7025_01284 HME7025_01284 1451666 1453096 + hypothetical protein gene gene-HME7025_01284 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01284 HME7025_01285 HME7025_01285 ruvA ruvA 1453099 1453686 + DNA helicase ATP-binding%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B SOS response.%3B RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates%2C in the presence of DNA%2C the weak ATPase activity of RuvB%3B Belongs to the RuvA family%3B KEGG: cth:Cthe_0181 holliday junction DNA helicase RuvA gene gene-HME7025_01285 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01285 HME7025_01286 HME7025_01286 HME7025_01286 1453755 1460837 + hypothetical protein gene gene-HME7025_01286 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01286 HME7025_01287 HME7025_01287 HME7025_01287 1460912 1461292 + Glycine cleavage system H protein Lipoyl.%3B The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein%3B Belongs to the GcvH family%3B Contains 1 lipoyl-binding domain gene gene-HME7025_01287 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01287 HME7025_01288 HME7025_01288 ura4 ura4 1461336 1462619 + Dihydroorotase Hydrolase%3B Metal-binding%3B Pyrimidine biosynthesis%3B Zinc.%3B Belongs to the DHOase family. Type 2 subfamily%3B KEGG: rsi:Runsl_1787 dihydroorotase gene gene-HME7025_01288 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01288 HME7025_01289 HME7025_01289 HME7025_01289 1462621 1463142 + hypothetical protein gene gene-HME7025_01289 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01289 HME7025_01290 HME7025_01290 HME7025_01290 1463147 1463692 + hypothetical protein gene gene-HME7025_01290 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01290 HME7025_01291 HME7025_01291 HME7025_01291 1463697 1464416 + hypothetical protein gene gene-HME7025_01291 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01291 HME7025_01292 HME7025_01292 HME7025_01292 1464409 1465026 - Spermidine/putrescine import ATP-binding protein PotA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: msm:MSMEG_6309 cystine transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene-HME7025_01292 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01292 HME7025_01293 HME7025_01293 lpxA lpxA 1465038 1465808 - Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Acyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Repeat%3B Transferase.%3B Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxD subfamily%3B KEGG: paca:ID47_02185 UDP-N-acetylglucosamine acyltransferase gene gene-HME7025_01293 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01293 HME7025_01294 HME7025_01294 lpxC lpxC 1465817 1467211 - UDP-3-O-acyl-N-acetylglucosamine deacetylase Hydrolase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism.%3B Involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the LpxC family%3B KEGG: hhl:Halha_2427 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase gene gene-HME7025_01294 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01294 HME7025_01295 HME7025_01295 lpxD lpxD 1467229 1468251 - UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Acyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Repeat%3B Transferase.%3B Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxD subfamily%3B KEGG: pre:PCA10_45240 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase gene gene-HME7025_01295 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01295 HME7025_01296 HME7025_01296 HME7025_01296 1468298 1469542 - Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Acetylation%3B Allosteric enzyme%3B Hydrolase%3B Immunity%3B Innate immunity%3B Metal-binding%3B Nucleus%3B Phosphoprotein%3B Ubl conjugation%3B Zinc.%3B Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise%2C suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling (By similarity)%3B Belongs to the SAMHD1 family%3B Contains 1 HD domain%3B Contains 1 SAM (sterile alpha motif) domain gene gene-HME7025_01296 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01296 HME7025_01297 HME7025_01297 HME7025_01297 1469548 1470261 - hypothetical protein gene gene-HME7025_01297 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01297 HME7025_01298 HME7025_01298 HME7025_01298 1470378 1470454 + tRNA-Met tRNA gene-HME7025_01298 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01298 HME7025_01299 HME7025_01299 HME7025_01299 1470763 1481778 + Non-specific serine/threonine protein kinase Glycoprotein%3B Membrane%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Virion%3B Virulence.%3B Virulence factor%3B KEGG: mmi:MMAR_4577 serine/threonine protein kinase%2C bacterial gene gene-HME7025_01299 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01299 HME7025_01300 HME7025_01300 xyoA xyoA 1481859 1483172 + Alditol oxidase FAD%3B Flavoprotein%3B Oxidoreductase.%3B Catalyzes the oxidation of xylitol to xylose%2C also acts on D-sorbitol%3B Belongs to the oxygen-dependent FAD-linked oxidoreductase family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: gob:Gobs_2565 xylitol oxidase gene gene-HME7025_01300 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01300 HME7025_01301 HME7025_01301 mdh1 mdh1 1483174 1485279 - Methanol dehydrogenase (cytochrome c) Calcium%3B Cell membrane%3B Disulfide bond%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B PQQ%3B Pyrrolidone carboxylic acid%3B Signal.%3B Catalyzes the oxidation of primary alcohols except for methanol that is not a substrate%3B Belongs to the bacterial PQQ dehydrogenase family%3B Contains 1 cytochrome c domain%3B KEGG: hdn:Hden_1323 methanol dehydrogenase (cytochrome c) subunit 1 gene gene-HME7025_01301 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01301 HME7025_01302 HME7025_01302 HME7025_01302 1485494 1486543 + L-rhamnose-proton symporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system)%3B Belongs to the L-rhamnose transporter (TC 2. A. 7. 6) family gene gene-HME7025_01302 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01302 HME7025_01303 HME7025_01303 HME7025_01303 1486544 1487575 + hypothetical protein gene gene-HME7025_01303 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01303 HME7025_01304 HME7025_01304 leuC leuC 1487696 1489099 + 3-isopropylmalate dehydratase 4Fe-4S%3B Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Iron%3B Iron-sulfur%3B Leucine biosynthesis%3B Lyase%3B Metal-binding.%3B Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate%2C via the formation of 2-isopropylmaleate%3B Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily%3B KEGG: gox:GOX0193 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit gene gene-HME7025_01304 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01304 HME7025_01305 HME7025_01305 leuD leuD 1489120 1489710 + 3-isopropylmalate dehydratase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Leucine biosynthesis%3B Lyase.%3B Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate%2C via the formation of 2-isopropylmaleate%3B Belongs to the LeuD family. LeuD type 1 subfamily%3B KEGG: lby:Lbys_2679 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit gene gene-HME7025_01305 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01305 HME7025_01306 HME7025_01306 nifV nifV 1489679 1491229 + Homocitrate synthase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Leucine biosynthesis%3B Transferase.%3B Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)%3B Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily%3B KEGG: dmt:DESME_04715 homocitrate synthase NifV gene gene-HME7025_01306 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01306 HME7025_01307 HME7025_01307 leuB leuB 1491248 1492321 + 3-isopropylmalate dehydrogenase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Cytoplasm%3B Leucine biosynthesis%3B Magnesium%3B Manganese%3B Metal-binding%3B NAD%3B Oxidoreductase.%3B Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate%3B Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily%3B KEGG: rsi:Runsl_0742 3-isopropylmalate dehydrogenase gene gene-HME7025_01307 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01307 HME7025_01308 HME7025_01308 HME7025_01308 1492372 1492869 + hypothetical protein gene gene-HME7025_01308 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01308 HME7025_01309 HME7025_01309 HME7025_01309 1492880 1495030 + putative peptidase Hydrolase%3B Protease%3B Serine protease.%3B Belongs to the peptidase S9B family%3B KEGG: bbd:Belba_2361 tricorn protease%3B Serine endopeptidases gene gene-HME7025_01309 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01309 HME7025_01310 HME7025_01310 HME7025_01310 1495137 1496216 - Cellulase Aminopeptidase%3B Hydrolase%3B Metal-binding%3B Metalloprotease%3B Protease.%3B Belongs to the peptidase M42 family%3B KEGG: gfo:GFO_1902 endoglucanase gene gene-HME7025_01310 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01310 HME7025_01311 HME7025_01311 pfkA pfkA 1496384 1497358 + 6-phosphofructokinase Allosteric enzyme%3B ATP-binding%3B Cytoplasm%3B Glycolysis%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1%2C6-bisphosphate by ATP%2C the first committing step of glycolysis%3B Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily%3B KEGG: psn:Pedsa_1833 6-phosphofructokinase 1 gene gene-HME7025_01311 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01311 HME7025_01312 HME7025_01312 HME7025_01312 1497355 1498131 - hypothetical protein gene gene-HME7025_01312 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01312 HME7025_01313 HME7025_01313 HME7025_01313 1498173 1499624 + hypothetical protein gene gene-HME7025_01313 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01313 HME7025_01314 HME7025_01314 HME7025_01314 1499617 1500501 - hypothetical protein gene gene-HME7025_01314 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01314 HME7025_01315 HME7025_01315 HME7025_01315 1500467 1501066 - RlpA-like lipoprotein Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal.%3B Belongs to the RlpA family gene gene-HME7025_01315 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01315 HME7025_01316 HME7025_01316 HME7025_01316 1501243 1501560 + hypothetical protein gene gene-HME7025_01316 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01316 HME7025_01317 HME7025_01317 HME7025_01317 1501651 1502754 + Ribosome-binding ATPase YchF ATP-binding%3B Magnesium%3B Metal-binding%3B Nucleotide-binding.%3B ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene-HME7025_01317 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01317 HME7025_01318 HME7025_01318 HME7025_01318 1502755 1503990 - hypothetical protein gene gene-HME7025_01318 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01318 HME7025_01319 HME7025_01319 znuC znuC 1503995 1505875 - Zinc import ATP-binding protein ZnuC ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Ion transport%3B Membrane%3B Nucleotide-binding%3B Transport%3B Zinc%3B Zinc transport.%3B Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Zinc importer (TC 3. A. 1. 15. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: yin:CH53_3805 zinc transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene-HME7025_01319 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01319 HME7025_01320 HME7025_01320 HME7025_01320 1505899 1507488 - Glutamate synthase (ferredoxin) Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the glutamate synthase family%3B KEGG: lil:LB_286 glutamate synthase (ferredoxin) gene gene-HME7025_01320 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01320 HME7025_01321 HME7025_01321 ybiC ybiC 1507600 1508679 + Malate dehydrogenase Cytoplasm%3B NAD%3B Oxidoreductase%3B Tricarboxylic acid cycle.%3B Belongs to the LDH2/MDH2 oxidoreductase family%3B KEGG: smaf:D781_1855 uncharacterized oxidoreductase%3B With NAD(+) or NADP(+) as acceptor gene gene-HME7025_01321 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01321 HME7025_01322 HME7025_01322 HME7025_01322 1508681 1509715 + UPF0755 protein Belongs to the UPF0755 family gene gene-HME7025_01322 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01322 HME7025_01323 HME7025_01323 ybgC ybgC 1509718 1510122 + Putative acyl-CoA thioesterase YneP Hydrolase.%3B Has acyl-CoA thioesterase activity%3B Belongs to the 4-hydroxybenzoyl-CoA thioesterase family%3B KEGG: tai:Taci_0608 acyl-CoA thioester hydrolase%3B Thiolester hydrolases gene gene-HME7025_01323 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01323 HME7025_01324 HME7025_01324 HME7025_01324 1510124 1511074 + Putative ribonuclease-like protein YfkH Cell membrane%3B Exonuclease%3B Hydrolase%3B Membrane%3B Nuclease%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_01324 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01324 HME7025_01325 HME7025_01325 tsaC tsaC 1511055 1511681 + L-threonylcarbamoyladenylate synthase Belongs to the SUA5 family%3B Contains 1 YrdC-like domain%3B KEGG: ran:Riean_1626 L-threonylcarbamoyladenylate synthase gene gene-HME7025_01325 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01325 HME7025_01326 HME7025_01326 lpxL lpxL 1511678 1512550 - Kdo(2)-lipid IV(A) lauroyltransferase KEGG: cyq:Q91_1354 KDO2-lipid IV(A) lauroyltransferase gene gene-HME7025_01326 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01326 HME7025_01327 HME7025_01327 HME7025_01327 1512614 1513225 + hypothetical protein gene gene-HME7025_01327 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01327 HME7025_01328 HME7025_01328 HME7025_01328 1513270 1515816 + putative ATP-dependent Clp protease ATP-binding subunit ATP-binding%3B Chaperone%3B Nucleotide-binding%3B Repeat.%3B Belongs to the ClpA/ClpB family. ClpC subfamily%3B Contains 1 UVR domain gene gene-HME7025_01328 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01328 HME7025_01329 HME7025_01329 lra1 lra1 1515835 1516581 + L-rhamnose 1-dehydrogenase NADP%3B Oxidoreductase.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: bpyr:ABD05_31635 L-rhamnose 1-dehydrogenase gene gene-HME7025_01329 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01329 HME7025_01330 HME7025_01330 HME7025_01330 1516581 1518395 + hypothetical protein gene gene-HME7025_01330 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01330 HME7025_01331 HME7025_01331 HME7025_01331 1518425 1519672 + hypothetical protein gene gene-HME7025_01331 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01331 HME7025_01332 HME7025_01332 HME7025_01332 1520144 1520776 + 30S ribosomal protein S16 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein S16P family gene gene-HME7025_01332 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01332 HME7025_01333 HME7025_01333 HME7025_01333 1520842 1521375 + Ribosome maturation factor RimM Chaperone%3B Cytoplasm%3B Ribosome biogenesis.%3B An accessory protein needed during the final step in the assembly of 30S ribosomal subunit%2C possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes%3B Belongs to the RimM family%3B Contains 1 PRC barrel domain gene gene-HME7025_01333 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01333 HME7025_01334 HME7025_01334 trmD trmD 1521362 1522039 + tRNA (guanine(37)-N(1))-methyltransferase Cytoplasm%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing.%3B Specifically methylates guanosine-37 in various tRNAs%3B Belongs to the RNA methyltransferase TrmD family%3B KEGG: aeh:Mlg_0886 tRNA (guanine37-N1)-methyltransferase gene gene-HME7025_01334 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01334 HME7025_01335 HME7025_01335 HME7025_01335 1522059 1522964 + putative inner membrane transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the EamA transporter family%3B Contains 2 EamA domains gene gene-HME7025_01335 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01335 HME7025_01336 HME7025_01336 HME7025_01336 1522961 1523866 + Endo-1%2C4-beta-xylanase Carbohydrate metabolism%3B Glycosidase%3B Hydrolase%3B Polysaccharide degradation%3B Xylan degradation.%3B B. fibrisolvens is located in the rumen of ruminant animals%2C where it contributes to the animal's digestion of plant material by hydrolyzing hemicellulose with its xylanases. Belongs to the glycosyl hydrolase 10 (cellulase F) family%3B Contains 1 GH10 (glycosyl hydrolase family 10) domain%3B KEGG: rba:RB3550 endo-1%2C4-beta-xylanase gene gene-HME7025_01336 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01336 HME7025_01337 HME7025_01337 HME7025_01337 1523851 1525260 - b(0%2C+)-type amino acid transporter Amino-acid transport%3B Cell membrane%3B Cystinuria%3B Disease mutation%3B Disulfide bond%3B Membrane%3B Phosphoprotein%3B Polymorphism%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Involved in the high-affinity%2C sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0%2C+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene-HME7025_01337 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01337 HME7025_01338 HME7025_01338 HME7025_01338 1525525 1526094 + hypothetical protein gene gene-HME7025_01338 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01338 HME7025_01339 HME7025_01339 HME7025_01339 1526408 1529398 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_01339 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01339 HME7025_01340 HME7025_01340 HME7025_01340 1529422 1531098 + hypothetical protein gene gene-HME7025_01340 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01340 HME7025_01341 HME7025_01341 HME7025_01341 1531171 1532220 + hypothetical protein gene gene-HME7025_01341 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01341 HME7025_01342 HME7025_01342 HME7025_01342 1532296 1533720 + Ribonuclease Cytoplasm%3B Endonuclease%3B Hydrolase%3B Metal-binding%3B Nuclease%3B RNA-binding%3B rRNA processing%3B Zinc.%3B Has endoribonuclease activity towards 23S and 16S rRNA (in vitro)%3B Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family gene gene-HME7025_01342 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01342 HME7025_01343 HME7025_01343 accA accA 1533754 1534710 + Acetyl-CoA carboxylase ATP-binding%3B Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Ligase%3B Lipid biosynthesis%3B Lipid metabolism%3B Nucleotide-binding.%3B Component of the acetyl coenzyme A carboxylase (ACC) complex. First%2C biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA%3B Belongs to the AccA family%3B KEGG: lby:Lbys_0311 acetyl-CoA carboxylase carboxyl transferase subunit alpha gene gene-HME7025_01343 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01343 HME7025_01344 HME7025_01344 HME7025_01344 1534716 1535354 + D-ribitol-5-phosphate phosphatase Hydrolase%3B Magnesium%3B Metal-binding.%3B Catalyzes the dephosphorylation of D-ribitol-5-phosphate and D-ribitol-1-phosphate. Is also able to dephosphorylate 5- amino-6-(5-phospho-D-ribitylamino)uracil%2C and thus could be involved in the riboflavin biosynthesis pathway%3B Belongs to the HAD-like hydrolase superfamily gene gene-HME7025_01344 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01344 HME7025_01345 HME7025_01345 HME7025_01345 1535387 1535905 + hypothetical protein gene gene-HME7025_01345 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01345 HME7025_01346 HME7025_01346 lpxB lpxB 1535893 1536999 - Lipid-A-disaccharide synthase Glycosyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Transferase.%3B Condensation of UDP-2%2C3-diacylglucosamine and 2%2C3- diacylglucosamine-1-phosphate to form lipid A disaccharide%2C a precursor of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the LpxB family%3B KEGG: pde:Pden_3909 lipid-A-disaccharide synthase gene gene-HME7025_01346 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01346 HME7025_01347 HME7025_01347 queD queD 1537000 1537422 - 6-pyruvoyltetrahydropterin synthase Disease mutation%3B Lyase%3B Metal-binding%3B Phenylketonuria%3B Phosphoprotein%3B Tetrahydrobiopterin biosynthesis%3B Zinc.%3B Involved in the biosynthesis of tetrahydrobiopterin%2C an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7%2C8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin%3B Belongs to the PTPS family%3B KEGG: eol:Emtol_4124 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase gene gene-HME7025_01347 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01347 HME7025_01348 HME7025_01348 gmhD gmhD 1537555 1538520 + ADP-glyceromanno-heptose 6-epimerase Carbohydrate metabolism%3B Isomerase%3B NADP.%3B Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily%3B KEGG: sfr:Sfri_3929 ADP-L-glycero-D-manno-heptose 6-epimerase gene gene-HME7025_01348 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01348 HME7025_01349 HME7025_01349 HME7025_01349 1538501 1539487 - putative glycosyltransferase Glycosyltransferase%3B Transferase.%3B Belongs to the glycosyltransferase 2 family%3B KEGG: pcc:PCC21_013360 alpha-1%2C3-rhamnosyltransferase%3B Hexosyltransferases gene gene-HME7025_01349 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01349 HME7025_01350 HME7025_01350 hemL hemL 1539515 1540807 - Glutamate-1-semialdehyde 2%2C1-aminomutase Cytoplasm%3B Isomerase%3B Porphyrin biosynthesis%3B Pyridoxal phosphate.%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily%3B KEGG: rsl:RPSI07_2684 glutamate-1-semialdehyde 2%2C1-aminomutase gene gene-HME7025_01350 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01350 HME7025_01351 HME7025_01351 HME7025_01351 1540810 1542627 - Membrane protein insertase YidC Cell inner membrane%3B Cell membrane%3B Chaperone%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex%2C as well as at least some lipoproteins. Aids folding of multispanning membrane proteins%3B Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily gene gene-HME7025_01351 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01351 HME7025_01352 HME7025_01352 pyrG pyrG 1542644 1544344 - CTP synthase (glutamine hydrolyzing) ATP-binding%3B Glutamine amidotransferase%3B Ligase%3B Nucleotide-binding%3B Pyrimidine biosynthesis.%3B Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen%3B Belongs to the CTP synthase family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: mga:MGA_0953 CTP synthase gene gene-HME7025_01352 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01352 HME7025_01353 HME7025_01353 HME7025_01353 1544395 1547721 + DNA helicase KEGG: azo:azo3213 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene-HME7025_01353 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01353 HME7025_01354 HME7025_01354 HME7025_01354 1547714 1548229 + hypothetical protein gene gene-HME7025_01354 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01354 HME7025_01355 HME7025_01355 lys1 lys1 1548291 1549505 + Saccharopine dehydrogenase (NAD(+)%2C L-lysine-forming) NADP%3B Oxidoreductase%3B Polyamine biosynthesis.%3B Required for norspermidine biosynthesis and for biofilm formation%3B Belongs to the saccharopine dehydrogenase family. carboxynorspermidine synthase subfamily%3B KEGG: sgp:SpiGrapes_2926 saccharopine dehydrogenase (NAD+%2C L-lysine forming) gene gene-HME7025_01355 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01355 HME7025_01356 HME7025_01356 nspC nspC 1549453 1550643 + Carboxynorspermidine decarboxylase Cytoplasm%3B Decarboxylase%3B Lyase%3B Polyamine biosynthesis%3B Pyridoxal phosphate%3B Spermidine biosynthesis.%3B Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine in vitro. In vivo%2C responsible for synthesizing spermidine%2C but not sym-norspermidine%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily%3B KEGG: gag:Glaag_0752 carboxynorspermidine decarboxylase gene gene-HME7025_01356 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01356 HME7025_01357 HME7025_01357 HME7025_01357 1550809 1550885 - tRNA-Ala tRNA gene-HME7025_01357 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01357 HME7025_01358 HME7025_01358 HME7025_01358 1550935 1551456 - hypothetical protein gene gene-HME7025_01358 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01358 HME7025_01359 HME7025_01359 hisC hisC 1551461 1552510 - Histidinol-phosphate transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Histidine biosynthesis%3B Pyridoxal phosphate%3B Transferase.%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily%3B KEGG: evi:Echvi_2458 histidinol-phosphate aminotransferase gene gene-HME7025_01359 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01359 HME7025_01360 HME7025_01360 hisD hisD 1552507 1553778 - Histidinol dehydrogenase Amino-acid biosynthesis%3B Histidine biosynthesis%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Zinc.%3B Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine%3B Belongs to the histidinol dehydrogenase family%3B KEGG: chz:CHSO_2472 histidinol dehydrogenase gene gene-HME7025_01360 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01360 HME7025_01361 HME7025_01361 hisG hisG 1553780 1554643 - ATP phosphoribosyltransferase Amino-acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Glycosyltransferase%3B Histidine biosynthesis%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity%3B Belongs to the ATP phosphoribosyltransferase family. Long subfamily%3B KEGG: msa:Mycsm_03785 ATP phosphoribosyltransferase gene gene-HME7025_01361 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01361 HME7025_01362 HME7025_01362 dlaT dlaT 1554705 1556315 - Dihydrolipoyllysine-residue acetyltransferase Acyltransferase%3B Glycolysis%3B Lipoyl%3B Mitochondrion%3B Transferase%3B Transit peptide.%3B The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: hoh:Hoch_3706 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene-HME7025_01362 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01362 HME7025_01363 HME7025_01363 HME7025_01363 1556388 1558175 - Translation factor GUF1 like protein%2C chloroplastic Chloroplast%3B GTP-binding%3B Hydrolase%3B Nucleotide-binding%3B Plastid%3B Protein biosynthesis%3B Transit peptide.%3B Promotes chloroplast protein synthesis. May act as a fidelity factor of the translation reaction%2C by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene-HME7025_01363 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01363 HME7025_01364 HME7025_01364 HME7025_01364 1558392 1559687 - Xaa-Pro aminopeptidase Aminopeptidase%3B Hydrolase%3B Manganese%3B Metal-binding%3B Metalloprotease%3B Protease.%3B Belongs to the peptidase M24B family%3B KEGG: sgn:SGRA_0242 Xaa-Pro aminopeptidase gene gene-HME7025_01364 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01364 HME7025_01365 HME7025_01365 ubiE ubiE 1559692 1560456 - Demethylmenaquinone methyltransferase Cytoplasm%3B Methyltransferase%3B Nucleus%3B Transferase.%3B Probable methyltransferase%3B KEGG: can:Cyan10605_0543 demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase gene gene-HME7025_01365 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01365 HME7025_01366 HME7025_01366 HME7025_01366 1560518 1561273 - hypothetical protein gene gene-HME7025_01366 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01366 HME7025_01367 HME7025_01367 HME7025_01367 1561361 1561504 - hypothetical protein gene gene-HME7025_01367 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01367 HME7025_01368 HME7025_01368 harS harS 1561594 1562952 + Histidine--tRNA ligase Alternative splicing%3B Aminoacyl-tRNA synthetase%3B ATP-binding%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Involved in protein synthesis (PubMed:23076791). Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: sht:KO02_02285 histidyl-tRNA synthetase gene gene-HME7025_01368 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01368 HME7025_01369 HME7025_01369 HME7025_01369 1563002 1564648 - Glucose-6-phosphate isomerase Cytoplasm%3B Gluconeogenesis%3B Glycolysis%3B Isomerase.%3B Belongs to the GPI family%3B KEGG: phe:Phep_0280 glucose-6-phosphate isomerase gene gene-HME7025_01369 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01369 HME7025_01370 HME7025_01370 HME7025_01370 1564654 1565439 - uncharacterized protein Glycosidase%3B Hydrolase.%3B Belongs to the glycosyl hydrolase 25 family gene gene-HME7025_01370 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01370 HME7025_01371 HME7025_01371 prdX prdX 1565452 1566087 - Peroxiredoxin Acetylation%3B Antioxidant%3B Cytoplasm%3B Cytoplasmic vesicle%3B Disulfide bond%3B Hydrolase%3B Lipid degradation%3B Lipid metabolism%3B Lysosome%3B Multifunctional enzyme%3B Oxidoreductase%3B Peroxidase%3B Phosphoprotein%3B Redox-active center.%3B Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Belongs to the AhpC/TSA family. Rehydrin subfamily%3B Contains 1 thioredoxin domain%3B KEGG: maq:Maqu_0381 peroxiredoxin (alkyl hydroperoxide reductase subunit C) gene gene-HME7025_01371 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01371 HME7025_01372 HME7025_01372 HME7025_01372 1566495 1566959 + putative HTH-type transcriptional regulator DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH asnC-type DNA-binding domain gene gene-HME7025_01372 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01372 HME7025_01373 HME7025_01373 HME7025_01373 1567041 1568489 + UPF0051 protein ABCI8%2C chloroplastic Chloroplast%3B Plastid%3B Transit peptide.%3B Involved in light signaling%2C probably by mediating the transport and correct distribution of protoporphyrin IX%2C a chlorophyll precursor%2C in response to far-red light%3B Belongs to the UPF0051 (ycf24) family gene gene-HME7025_01373 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01373 HME7025_01374 HME7025_01374 HME7025_01374 1568491 1569303 - 1-aminocyclopropane-1-carboxylate deaminase Hydrolase%3B Pyridoxal phosphate.%3B Catalyzes a cyclopropane ring-opening reaction%2C the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source%3B Belongs to the ACC deaminase/D-cysteine desulfhydrase family%3B KEGG: zpr:ZPR_0795 1-aminocyclopropane-1-carboxylate deaminase gene gene-HME7025_01374 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01374 HME7025_01375 HME7025_01375 rluD rluD 1569353 1570396 + 23S rRNA pseudouridine(1911/1915/1917) synthase Isomerase%3B RNA-binding%3B rRNA processing.%3B Responsible for synthesis of pseudouridine from uracil at positions 1911%2C 1915 and 1917 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: rbc:BN938_1494 23S rRNA pseudouridine1911/1915/1917 synthase gene gene-HME7025_01375 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01375 HME7025_01376 HME7025_01376 speG speG 1570377 1570829 + Diamine N-acetyltransferase Acyltransferase%3B Cytoplasm%3B Transferase.%3B Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine %3D spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1%2C3-diaminopropane%2C 1%2C5-diaminopentane%2C putrescine%2C spermidine (forming N(1)- and N(8)-acetylspermidine)%2C spermine%2C N(1)-acetylspermidine and N(8)-acetylspermidine (By similarity)%3B Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: hst:105186849 diamine N-acetyltransferase gene gene-HME7025_01376 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01376 HME7025_01377 HME7025_01377 HME7025_01377 1570849 1572156 - Arabinose-proton symporter Cell membrane%3B Membrane%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system)%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene-HME7025_01377 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01377 HME7025_01378 HME7025_01378 HME7025_01378 1572228 1573364 - Membrane protein MosC Alternative initiation%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport. gene gene-HME7025_01378 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01378 HME7025_01379 HME7025_01379 HME7025_01379 1573377 1573901 - Putative 5'(3')-deoxyribonucleotidase Hydrolase.%3B Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides%3B Belongs to the 5'(3')-deoxyribonucleotidase family gene gene-HME7025_01379 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01379 HME7025_01380 HME7025_01380 HME7025_01380 1573963 1575594 - 60 kDa chaperonin ATP-binding%3B Chaperone%3B Cytoplasm%3B Nucleotide-binding.%3B Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions%3B Belongs to the chaperonin (HSP60) family gene gene-HME7025_01380 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01380 HME7025_01381 HME7025_01381 HME7025_01381 1575641 1575919 - 10 kDa chaperonin Chaperone%3B Cytoplasm.%3B Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter%3B Belongs to the GroES chaperonin family gene gene-HME7025_01381 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01381 HME7025_01382 HME7025_01382 HME7025_01382 1576054 1576380 - hypothetical protein gene gene-HME7025_01382 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01382 HME7025_01383 HME7025_01383 HME7025_01383 1576388 1576930 - hypothetical protein gene gene-HME7025_01383 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01383 HME7025_01384 HME7025_01384 HME7025_01384 1576934 1577440 - hypothetical protein gene gene-HME7025_01384 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01384 HME7025_01385 HME7025_01385 HME7025_01385 1577418 1578728 - Transcriptional regulatory protein ZraR Activator%3B ATP-binding%3B Cytoplasm%3B DNA-binding%3B Nucleotide-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system.%3B Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity)%3B Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene-HME7025_01385 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01385 HME7025_01386 HME7025_01386 miaB miaB 1578730 1580148 - tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing.%3B Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A)%2C leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine%3B Belongs to the methylthiotransferase family. MiaB subfamily%3B Contains 1 MTTase N-terminal domain%3B Contains 1 TRAM domain%3B KEGG: jan:Jann_0697 tRNA-2-methylthio-N6-dimethylallyladenosine synthase gene gene-HME7025_01386 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01386 HME7025_01387 HME7025_01387 HME7025_01387 1580201 1580854 - Autoinducer 2 import ATP-binding protein LsrA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Repeat%3B Transport.%3B Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3. A. 1. 2. 8) family%3B Contains 2 ABC transporter domains gene gene-HME7025_01387 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01387 HME7025_01388 HME7025_01388 sucC sucC 1580950 1582140 + Succinate--CoA ligase (ADP-forming) ATP-binding%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide-binding%3B Tricarboxylic acid cycle.%3B Belongs to the succinate/malate CoA ligase beta subunit family%3B Contains 1 ATP-grasp domain%3B KEGG: aci:ACIAD2873 succinyl-CoA synthetase beta subunit gene gene-HME7025_01388 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01388 HME7025_01389 HME7025_01389 hpaF hpaF 1582151 1582762 + 5-carboxymethyl-2-hydroxymuconate Delta-isomerase Hydrolase%3B Metal-binding.%3B May have hydrolase activity%3B Belongs to the FAH family%3B KEGG: gur:Gura_3666 5-carboxymethyl-2-hydroxymuconate isomerase gene gene-HME7025_01389 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01389 HME7025_01390 HME7025_01390 prxQ prxQ 1582764 1583210 + Peroxiredoxin Oxidoreductase%3B Peroxidase%3B Redox-active center.%3B Belongs to the AhpC/TSA family%3B Contains 1 thioredoxin domain%3B KEGG: mme:Marme_1982 peroxiredoxin Q/BCP gene gene-HME7025_01390 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01390 HME7025_01391 HME7025_01391 HME7025_01391 1583220 1584077 + Transketolase Calcium%3B Metal-binding%3B Thiamine pyrophosphate%3B Transferase.%3B Belongs to the transketolase family%3B KEGG: cbo:CBO3395 transketolase gene gene-HME7025_01391 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01391 HME7025_01392 HME7025_01392 HME7025_01392 1584087 1585037 + Transketolase Isoprene biosynthesis%3B Magnesium%3B Metal-binding%3B Thiamine biosynthesis%3B Thiamine pyrophosphate%3B Transferase.%3B Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%3B Belongs to the transketolase family. DXPS subfamily%3B KEGG: rbc:BN938_2352 transketolase gene gene-HME7025_01392 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01392 HME7025_01393 HME7025_01393 HME7025_01393 1585039 1587321 - hypothetical protein gene gene-HME7025_01393 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01393 HME7025_01394 HME7025_01394 HME7025_01394 1587325 1588053 + tRNA (guanosine(18)-2'-O)-methyltransferase Cytoplasm%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing.%3B Specifically methylates guanosine-18 in various tRNAs%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family gene gene-HME7025_01394 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01394 HME7025_01395 HME7025_01395 HME7025_01395 1588050 1588787 - hypothetical protein gene gene-HME7025_01395 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01395 HME7025_01396 HME7025_01396 alaA alaA 1588784 1589995 - Valine--pyruvate transaminase Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase.%3B Involved in the biosynthesis of alanine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: msr:AU15_13025 alanine-synthesizing transaminase gene gene-HME7025_01396 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01396 HME7025_01397 HME7025_01397 HME7025_01397 1590058 1590759 + hypothetical protein gene gene-HME7025_01397 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01397 HME7025_01398 HME7025_01398 HME7025_01398 1590761 1591303 + hypothetical protein gene gene-HME7025_01398 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01398 HME7025_01399 HME7025_01399 purC purC 1591306 1592253 + Phosphoribosylaminoimidazolesuccinocarboxamide synthase ATP-binding%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis.%3B Belongs to the SAICAR synthetase family%3B KEGG: nko:Niako_1547 phosphoribosylaminoimidazole-succinocarboxamide synthase gene gene-HME7025_01399 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01399 HME7025_01400 HME7025_01400 HME7025_01400 1592243 1592680 + hypothetical protein gene gene-HME7025_01400 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01400 HME7025_01401 HME7025_01401 gltB gltB 1592883 1597451 + Glutamate synthase (NADPH) 3Fe-4S%3B Amino-acid biosynthesis%3B FAD%3B Flavoprotein%3B FMN%3B Glutamate biosynthesis%3B Glutamine amidotransferase%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NADP%3B Oxidoreductase.%3B Belongs to the glutamate synthase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: ajs:Ajs_0741 glutamate synthase (NADPH/NADH) large chain gene gene-HME7025_01401 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01401 HME7025_01402 HME7025_01402 gltD gltD 1597461 1598957 + Glutamate synthase (NADPH) Amino-acid biosynthesis%3B Glutamate biosynthesis%3B NADP%3B Oxidoreductase.%3B Belongs to the glutamate synthase family%3B KEGG: mca:MCA2040 glutamate synthase (NADPH/NADH) small chain gene gene-HME7025_01402 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01402 HME7025_01403 HME7025_01403 HME7025_01403 1599021 1599107 + tRNA-Ser tRNA gene-HME7025_01403 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01403 HME7025_01404 HME7025_01404 HME7025_01404 1599119 1599195 + tRNA-Pro tRNA gene-HME7025_01404 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01404 HME7025_01405 HME7025_01405 HME7025_01405 1599253 1599329 + tRNA-Arg tRNA gene-HME7025_01405 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01405 HME7025_01406 HME7025_01406 HME7025_01406 1599405 1600682 + hypothetical protein gene gene-HME7025_01406 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01406 HME7025_01407 HME7025_01407 pimB pimB 1600705 1601892 + Alpha-galactosylglucosyldiacylglycerol synthase Antibiotic resistance%3B Carbohydrate metabolism%3B Cell membrane%3B Glycerol metabolism%3B Glycosyltransferase%3B Lipid biosynthesis%3B Lipid metabolism%3B Magnesium%3B Membrane%3B Transferase.%3B Galactosyltransferase involved in the biosynthesis of the bilayer-forming membrane lipid alpha-galactosyl- glucosyldiacylglycerol which is involved in maintaining constant nonbilayer/bilayer conditions (curvature packing stress). Also involved in the beta-lactam resistance. Catalyzes the transfer of a galactosyl residue from UDP-Gal to alpha-glucosyl-DAG (1%2C2- diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol) acceptor to form the corresponding galactosyl-glycosyl-DAG product (3-O-alpha-(D- galactopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1%2C2-diacyl-sn- glycerol). It can only use UDP-Gal as sugar donor and alpha- glucosyl-DAG is the preferred sugar acceptor%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: aaus:EP12_13930 phosphatidylinositol alpha-1%2C6-mannosyltransferase%3B Hexosyltransferases gene gene-HME7025_01407 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01407 HME7025_01408 HME7025_01408 wbpZ wbpZ 1601878 1603017 - putative glycosyltransferase Glycosyltransferase%3B Transferase.%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: azo:azo3584 rhamnosyl/mannosyltransferase%3B Hexosyltransferases gene gene-HME7025_01408 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01408 HME7025_01409 HME7025_01409 HME7025_01409 1603221 1604105 + hypothetical protein gene gene-HME7025_01409 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01409 HME7025_01410 HME7025_01410 wcaF wcaF 1604102 1604650 + Putative colanic acid biosynthesis acetyltransferase WcaF Acyltransferase%3B Lipopolysaccharide biosynthesis%3B Repeat%3B Transferase.%3B Belongs to the transferase hexapeptide repeat family%3B KEGG: lby:Lbys_1215 putative colanic acid biosynthesis acetyltransferase WcaF%3B Transferring groups other than amino-acyl groups gene gene-HME7025_01410 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01410 HME7025_01411 HME7025_01411 wecA wecA 1604655 1605848 + UDP-N-acetylglucosamine--undecaprenyl-phosphateN-acetylglucosaminephosphotransferase Cell cycle%3B Cell division%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Peptidoglycan synthesis%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan%3B Belongs to the glycosyltransferase 4 family. MraY subfamily%3B KEGG: vpr:Vpar_1542 UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase gene gene-HME7025_01411 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01411 HME7025_01412 HME7025_01412 mshA mshA 1605838 1606932 - D-inositol-3-phosphate glycosyltransferase Glycosyltransferase%3B Magnesium%3B Metal-binding%3B Transferase.%3B Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway%3B Belongs to the glycosyltransferase group 1 family. MshA subfamily%3B KEGG: cjk:jk1914 D-inositol-3-phosphate glycosyltransferase gene gene-HME7025_01412 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01412 HME7025_01413 HME7025_01413 pheA pheA 1607022 1608101 + Chorismate mutase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Cytoplasm%3B Isomerase%3B Lyase%3B Multifunctional enzyme%3B Phenylalanine biosynthesis.%3B Contains 1 ACT domain%3B Contains 1 chorismate mutase domain%3B Contains 1 prephenate dehydratase domain%3B KEGG: cff:CFF8240_0269 chorismate mutase / prephenate dehydratase gene gene-HME7025_01413 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01413 HME7025_01414 HME7025_01414 ribF ribF 1608075 1609022 - Riboflavin kinase ATP-binding%3B FAD%3B Flavoprotein%3B FMN%3B Kinase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B Belongs to the RibF family%3B KEGG: rbt:NOVO_03145 riboflavin kinase / FMN adenylyltransferase gene gene-HME7025_01414 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01414 HME7025_01415 HME7025_01415 truB truB 1609006 1609695 - tRNA pseudouridine(55) synthase Isomerase%3B tRNA processing.%3B Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs%3B Belongs to the pseudouridine synthase TruB family. Type 1 subfamily%3B KEGG: sbw:TGUWTKB_1910 tRNA pseudouridine55 synthase gene gene-HME7025_01415 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01415 HME7025_01416 HME7025_01416 bacA bacA 1609683 1610471 - Undecaprenyl-diphosphate phosphatase Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Hydrolase%3B Membrane%3B Peptidoglycan synthesis%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)%3B Belongs to the UppP family%3B KEGG: bsb:Bresu_3140 undecaprenyl-diphosphatase gene gene-HME7025_01416 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01416 HME7025_01417 HME7025_01417 HME7025_01417 1610471 1610683 - hypothetical protein gene gene-HME7025_01417 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01417 HME7025_01418 HME7025_01418 HME7025_01418 1610685 1611569 - Cell division protein FtsX Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Required for cell division and gliding motility%3B Belongs to the ABC-4 integral membrane protein family. FtsX subfamily gene gene-HME7025_01418 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01418 HME7025_01419 HME7025_01419 HME7025_01419 1611566 1612159 - uncharacterized protein Contains 1 BFN domain gene gene-HME7025_01419 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01419 HME7025_01420 HME7025_01420 HME7025_01420 1612203 1613159 - Electron transfer flavoprotein subunit alpha%2C mitochondrial Electron transport%3B FAD%3B Flavoprotein%3B Mitochondrion%3B Transit peptide%3B Transport.%3B The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases%2C including five acyl- CoA dehydrogenases%2C glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Involved in leucine catabolism and in phytol degradation (By similarity)%3B Belongs to the ETF alpha-subunit/FixB family gene gene-HME7025_01420 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01420 HME7025_01421 HME7025_01421 HME7025_01421 1613161 1613892 - Electron transfer flavoprotein subunit beta Electron transport%3B FAD%3B Flavoprotein%3B Transport.%3B The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity)%3B Belongs to the ETF beta-subunit/FixA family gene gene-HME7025_01421 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01421 HME7025_01422 HME7025_01422 HME7025_01422 1613949 1614257 + hypothetical protein gene gene-HME7025_01422 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01422 HME7025_01423 HME7025_01423 parE parE 1614254 1616044 - DNA topoisomerase 4 subunit ATP-binding%3B DNA-binding%3B Isomerase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Topoisomerase.%3B Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity)%3B Belongs to the type II topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: dps:DP2280 topoisomerase IV subunit B%3B Other isomerases gene gene-HME7025_01423 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01423 HME7025_01424 HME7025_01424 HME7025_01424 1616257 1618869 + Polysialic acid transport protein KpsD Capsule biogenesis/degradation%3B Periplasm%3B Signal%3B Transport.%3B Involved in the translocation of the polysialic acid capsule across the outer membrane to the cell surface. May function as the periplasmic binding element of the PSA transport system%2C in which it transiently interacts with the membrane component of the transporter%2C binds polysaccharide and transports the polymer to a component in the outer membrane. To E. coli K5 KpsD gene gene-HME7025_01424 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01424 HME7025_01425 HME7025_01425 HME7025_01425 1618874 1619932 + hypothetical protein gene gene-HME7025_01425 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01425 HME7025_01426 HME7025_01426 HME7025_01426 1619938 1620741 + O-antigen export system permease protein RfbA Cell inner membrane%3B Cell membrane%3B Membrane%3B Polysaccharide transport%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B May form an ATP-driven O-antigen export apparatus%2C in association with RfbB. Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene-HME7025_01426 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01426 HME7025_01427 HME7025_01427 proV proV 1620747 1621967 + Quaternary-amine-transporting ATPase ATP-binding%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Teichoic acids exporter (TC 3. A. 1. 104. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: hhd:HBHAL_2207 glycine betaine/proline transport system ATP-binding protein gene gene-HME7025_01427 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01427 HME7025_01428 HME7025_01428 HME7025_01428 1621970 1623040 + dTDP-4-amino-4%2C6-dideoxy-D-glucose transaminase Aminotransferase%3B Lipopolysaccharide biosynthesis%3B Pyridoxal phosphate%3B Transferase.%3B Catalyzes the conversion of dTDP-4-dehydro-6-deoxy-D- glucose (dTDP-D-Glc4O) to dTDP-4-amino-4%2C6-dideoxy-D-glucose (dTDP-D-Qui4N)%3B Belongs to the DegT/DnrJ/EryC1 family%3B KEGG: gfo:GFO_2033 null%3B Transaminases gene gene-HME7025_01428 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01428 HME7025_01429 HME7025_01429 HME7025_01429 1623048 1625060 + hypothetical protein gene gene-HME7025_01429 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01429 HME7025_01430 HME7025_01430 HME7025_01430 1625057 1626328 - hypothetical protein gene gene-HME7025_01430 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01430 HME7025_01431 HME7025_01431 HME7025_01431 1626394 1627632 + Macrolide export ATP-binding/permease protein MacB Antibiotic resistance%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain gene gene-HME7025_01431 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01431 HME7025_01432 HME7025_01432 HME7025_01432 1627704 1627790 + tRNA-Leu tRNA gene-HME7025_01432 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01432 HME7025_01433 HME7025_01433 xylB xylB 1627822 1629297 - Xylulokinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Xylose metabolism.%3B Belongs to the FGGY kinase family%3B KEGG: doi:FH5T_14630 xylulokinase gene gene-HME7025_01433 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01433 HME7025_01434 HME7025_01434 HME7025_01434 1629312 1630061 + Fe(3+)-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Plasmid%3B Repeat%3B Sugar transport%3B Transport.%3B Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Ribose importer (TC 3. A. 1. 2. 1) family%3B Contains 2 ABC transporter domains%3B KEGG: hym:N008_10705 iron(III) transport system ATP-binding protein gene gene-HME7025_01434 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01434 HME7025_01435 HME7025_01435 tatD tatD 1630050 1630820 - 3'-5' ssDNA/RNA exonuclease TatD Cytoplasm%3B Exonuclease%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease.%3B 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair%3B Belongs to the TatD-type hydrolase family. TatD subfamily%3B KEGG: vch:VC0103 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene-HME7025_01435 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01435 HME7025_01436 HME7025_01436 pdaA pdaA 1630817 1631446 - Chitooligosaccharide deacetylase Cytoplasm%3B Hydrolase%3B Metal-binding%3B Nodulation%3B Plasmid.%3B Is involved in generating a small heat-stable compound (Nod)%2C an acylated oligomer of N-acetylglucosamine%2C that stimulates mitosis in various plant protoplasts. Belongs to the polysaccharide deacetylase family%3B KEGG: beo:BEH_02735 peptidoglycan-N-acetylmuramic acid deacetylase%3B In linear amides gene gene-HME7025_01436 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01436 HME7025_01437 HME7025_01437 ruvC ruvC 1631467 1632039 + Crossover junction endodeoxyribonuclease DNA damage%3B DNA recombination%3B DNA repair%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease.%3B Nuclease that resolves Holliday junction intermediates in genetic recombination%3B Belongs to the RuvC family%3B KEGG: bbd:Belba_1895 crossover junction endodeoxyribonuclease RuvC gene gene-HME7025_01437 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01437 HME7025_01438 HME7025_01438 HME7025_01438 1632032 1633981 - Spermatoproteinis-associated protein Alternative splicing%3B Developmental protein%3B Differentiation%3B Phosphoprotein%3B Polymorphism%3B Secreted%3B Signal%3B Spermatogenesis.%3B May play a role in fertility regulation gene gene-HME7025_01438 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01438 HME7025_01439 HME7025_01439 HME7025_01439 1634022 1635581 + uncharacterized protein gene gene-HME7025_01439 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01439 HME7025_01440 HME7025_01440 HME7025_01440 1635590 1636165 + putative Nudix hydrolase NudL Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding.%3B Probably mediates the hydrolysis of some nucleoside diphosphate derivatives%3B Belongs to the Nudix hydrolase family. PCD1 subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: hsa:254552 nudix motif 8%3B In phosphorus-containing anhydrides gene gene-HME7025_01440 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01440 HME7025_01441 HME7025_01441 parC parC 1636175 1638892 + DNA topoisomerase 4 subunit Cell membrane%3B DNA-binding%3B Isomerase%3B Membrane%3B Topoisomerase.%3B Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule%3B Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily%3B KEGG: mtt:Ftrac_0640 topoisomerase IV subunit A%3B Other isomerases gene gene-HME7025_01441 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01441 HME7025_01442 HME7025_01442 HME7025_01442 1638925 1640208 + Autophagy-related protein 22 Amino-acid transport%3B Autophagy%3B Glycoprotein%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Vacuole.%3B Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity)%3B Belongs to the ATG22 family gene gene-HME7025_01442 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01442 HME7025_01443 HME7025_01443 HME7025_01443 1640195 1641115 - Hydrogen peroxide-inducible protein activator Activator%3B DNA-binding%3B Transcription%3B Transcription regulation.%3B Required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase and glutathione- reductase%3B Contains 1 HTH lysR-type DNA-binding domain gene gene-HME7025_01443 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01443 HME7025_01444 HME7025_01444 HME7025_01444 1641157 1641765 + Peroxiredoxin Oxidoreductase%3B Peroxidase%3B Redox-active center.%3B Belongs to the AhpC/TSA family%3B Contains 1 thioredoxin domain%3B KEGG: nko:Niako_6351 peroxiredoxin (alkyl hydroperoxide reductase subunit C) gene gene-HME7025_01444 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01444 HME7025_01445 HME7025_01445 HME7025_01445 1641812 1642384 + Alkyl hydroperoxide reductase AhpD Antioxidant%3B Disulfide bond%3B Oxidoreductase%3B Peroxidase%3B Redox-active center.%3B Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity%3B Belongs to the AhpD family gene gene-HME7025_01445 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01445 HME7025_01446 HME7025_01446 HME7025_01446 1642392 1643783 - UDP-galactopyranose mutase KEGG: dde:Dde_0216 UDP-galactopyranose mutase gene gene-HME7025_01446 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01446 HME7025_01447 HME7025_01447 HME7025_01447 1643780 1644529 - hypothetical protein gene gene-HME7025_01447 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01447 HME7025_01448 HME7025_01448 HME7025_01448 1644531 1645655 - hypothetical protein gene gene-HME7025_01448 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01448 HME7025_01449 HME7025_01449 HME7025_01449 1645655 1647682 - Photosystem I P700 chlorophyll a apoprotein A2 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Chlorophyll%3B Chromophore%3B Electron transport%3B Iron%3B Iron-sulfur%3B Magnesium%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Photosynthesis%3B Photosystem I%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B PsaA and PsaB bind P700%2C the primary electron donor of photosystem I (PSI)%2C as well as the electron acceptors A0%2C A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase%2C converting photonic excitation into a charge separation%2C which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0%2C A1%2C FX%2C FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6. Belongs to the PsaA/PsaB family%3B Contains 1 OmpA-like domain gene gene-HME7025_01449 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01449 HME7025_01450 HME7025_01450 HME7025_01450 1647688 1648350 - Ribulose-phosphate 3-epimerase Carbohydrate metabolism%3B Cobalt%3B Iron%3B Isomerase%3B Manganese%3B Metal-binding%3B Zinc.%3B Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate%3B Belongs to the ribulose-phosphate 3-epimerase family%3B KEGG: ben:BOBLI757_577 ribulose-phosphate 3-epimerase gene gene-HME7025_01450 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01450 HME7025_01451 HME7025_01451 HME7025_01451 1648432 1650432 + DNA ligase (NAD(+)) DNA damage%3B DNA repair%3B DNA replication%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B NAD%3B Zinc.%3B DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA%3B Belongs to the NAD-dependent DNA ligase family. LigA subfamily%3B Contains 1 BRCT domain%3B KEGG: mge:MG_254 DNA ligase (NAD+) gene gene-HME7025_01451 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01451 HME7025_01452 HME7025_01452 HME7025_01452 1650436 1651329 + 4-hydroxy-tetrahydrodipicolinate synthase Amino-acid biosynthesis%3B Cytoplasm%3B Diaminopimelate biosynthesis%3B Lyase%3B Lysine biosynthesis%3B Schiff base.%3B Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)%3B Belongs to the DapA family%3B KEGG: vei:Veis_1046 4-hydroxy-tetrahydrodipicolinate synthase gene gene-HME7025_01452 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01452 HME7025_01453 HME7025_01453 HME7025_01453 1651334 1651636 + hypothetical protein gene gene-HME7025_01453 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01453 HME7025_01454 HME7025_01454 HME7025_01454 1651617 1652066 + hypothetical protein gene gene-HME7025_01454 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01454 HME7025_01455 HME7025_01455 HME7025_01455 1652032 1653468 - Alpha-L-fucosidase Apoplast%3B Glycoprotein%3B Glycosidase%3B Hydrolase%3B Secreted%3B Signal.%3B Hydrolyzes both 3- and 4-linked fucoses in Lewis determinants. Not active on neither 2-linked fucose nor on fucose in alpha-1%2C3-linkage to the innermost GlcNAc%3B Belongs to the glycosyl hydrolase 29 family%3B KEGG: evi:Echvi_1160 alpha-L-fucosidase gene gene-HME7025_01455 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01455 HME7025_01456 HME7025_01456 HME7025_01456 1653517 1653606 - hypothetical protein gene gene-HME7025_01456 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01456 HME7025_01457 HME7025_01457 HME7025_01457 1653691 1655034 + L-fucose-proton symporter Carbohydrate metabolism%3B Cell inner membrane%3B Cell membrane%3B Fucose metabolism%3B Membrane%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose%2C but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose%3B Belongs to the major facilitator superfamily. FHS transporter (TC 2. A. 1. 7) family gene gene-HME7025_01457 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01457 HME7025_01458 HME7025_01458 HME7025_01458 1655039 1655368 + L-rhamnose mutarotase Isomerase.%3B Plays a role in the catabolism of L-fucose. Involved in the anomeric conversion of L-fucose%3B Belongs to the RbsD / FucU family. FucU mutarotase subfamily%3B KEGG: cfu:CFU_4369 L-rhamnose mutarotase gene gene-HME7025_01458 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01458 HME7025_01459 HME7025_01459 uxaA uxaA 1655383 1657038 + Altronate dehydratase Iron%3B Lyase%3B Manganese.%3B Catalyzes the dehydration of D-altronate%3B Belongs to the UxaA family%3B KEGG: cao:Celal_2507 altronate hydrolase gene gene-HME7025_01459 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01459 HME7025_01460 HME7025_01460 HME7025_01460 1657050 1657817 + 3-oxoacyl-[acyl-carrier-protein] reductase Oxidoreductase.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: ped:ING2D1G_0430 3-oxoacyl-(acyl-carrier protein) reductase gene gene-HME7025_01460 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01460 HME7025_01461 HME7025_01461 HME7025_01461 1657828 1658505 + hypothetical protein gene gene-HME7025_01461 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01461 HME7025_01462 HME7025_01462 HME7025_01462 1658529 1659377 + 5-carboxymethyl-2-hydroxymuconate Delta-isomerase Metal-binding.%3B Belongs to the FAH family%3B KEGG: nar:Saro_2426 5-carboxymethyl-2-hydroxymuconate isomerase gene gene-HME7025_01462 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01462 HME7025_01463 HME7025_01463 HME7025_01463 1659379 1660209 + hypothetical protein gene gene-HME7025_01463 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01463 HME7025_01464 HME7025_01464 HME7025_01464 1660209 1660991 + 3-oxoacyl-[acyl-carrier-protein] reductase Oxidoreductase.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: reh:H16_B0361 3-oxoacyl-(acyl-carrier protein) reductase gene gene-HME7025_01464 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01464 HME7025_01465 HME7025_01465 dsdA dsdA 1660993 1662084 + D-serine ammonia-lyase KEGG: ptx:ABW99_13940 D-serine dehydratase gene gene-HME7025_01465 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01465 HME7025_01466 HME7025_01466 dpeP dpeP 1662086 1663153 + Membrane dipeptidase KEGG: saci:Sinac_3887 membrane dipeptidase gene gene-HME7025_01466 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01466 HME7025_01467 HME7025_01467 HME7025_01467 1663236 1663985 - 3-oxoacyl-[acyl-carrier-protein] reductase Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B NADP%3B Oxidoreductase.%3B Catalyzes the NADPH-dependent reduction of beta- ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products%2C the first reductive step in the elongation cycle of fatty acid biosynthesis%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pha:PSHAa0894 3-oxoacyl-(acyl-carrier protein) reductase gene gene-HME7025_01467 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01467 HME7025_01468 HME7025_01468 ilvD ilvD 1664041 1665756 - Dihydroxy-acid dehydratase 4Fe-4S%3B Arabinose catabolism%3B Carbohydrate metabolism%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding.%3B Catalyzes the dehydration of L-arabonate to L-2-keto-3- deoxyarabonate (L-KDA). Is involved in a degradation pathway of L- arabinose that allows A. brasilense to grow on L-arabinose as a sole carbon source. To a lesser extent%2C can also use D-xylonate as substrate%2C but not D-galactonate%2C D-arabonate%2C and D-gluconate%3B Belongs to the IlvD/Edd family%3B KEGG: dfe:Dfer_4563 dihydroxy-acid dehydratase gene gene-HME7025_01468 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01468 HME7025_01469 HME7025_01469 HME7025_01469 1665753 1666403 - hypothetical protein gene gene-HME7025_01469 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01469 HME7025_01470 HME7025_01470 patB patB 1666405 1667541 - Cystathionine beta-lyase Amino-acid biosynthesis%3B Lyase%3B Methionine biosynthesis%3B Pyridoxal phosphate.%3B Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro%2C producing sulfide from cysteine. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily%3B KEGG: hso:HS_0792 cystathione beta-lyase gene gene-HME7025_01470 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01470 HME7025_01471 HME7025_01471 HME7025_01471 1667538 1668353 - hypothetical protein gene gene-HME7025_01471 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01471 HME7025_01472 HME7025_01472 nplT nplT 1668350 1670056 - Neopullulanase Carbohydrate metabolism%3B Glycosyltransferase%3B Transferase.%3B Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose%2C together with TreS%2C Mak and GlgB%3B Belongs to the glycosyl hydrolase 13 family. GlgE subfamily%3B KEGG: pha:PSHAa1355 neopullulanase gene gene-HME7025_01472 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01472 HME7025_01473 HME7025_01473 pgmB pgmB 1670235 1670882 + Beta-phosphoglucomutase Carbohydrate metabolism%3B Cytoplasm%3B Isomerase%3B Magnesium%3B Metal-binding%3B Phosphoprotein.%3B Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P)%2C and forming beta-D-glucose 1%2C6-(bis)phosphate (beta-G16P) as an intermediate. The beta- phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose (By similarity)%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: csh:Closa_0065 beta-phosphoglucomutase gene gene-HME7025_01473 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01473 HME7025_01474 HME7025_01474 mapA mapA 1670913 1673213 + Maltose phosphorylase Carbohydrate metabolism%3B Glycosyltransferase%3B Transferase.%3B Catalyzes the phosphorolysis of maltose%2C leading to the formation of glucose and glucose 1-P%3B Belongs to the glycosyl hydrolase 65 family%3B KEGG: sht:KO02_04265 maltose phosphorylase gene gene-HME7025_01474 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01474 HME7025_01475 HME7025_01475 degS degS 1673260 1674261 - Putative sphingolipid delta(4)-desaturase/C4-monooxygenase Lipid metabolism%3B Membrane%3B Oxidoreductase%3B Sphingolipid metabolism%3B Transmembrane%3B Transmembrane helix.%3B Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase%3B Belongs to the fatty acid desaturase family. DEGS subfamily%3B KEGG: mlr:MELLADRAFT_94954 sphingolipid delta-4 desaturase%3B Acting on paired donors%2C with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2) gene gene-HME7025_01475 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01475 HME7025_01476 HME7025_01476 HME7025_01476 1674433 1676322 + Chaperone protein DnaK ATP-binding%3B Chaperone%3B Nucleotide-binding%3B Phosphoprotein%3B Stress response.%3B Acts as a chaperone%3B Belongs to the heat shock protein 70 family gene gene-HME7025_01476 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01476 HME7025_01477 HME7025_01477 HME7025_01477 1676419 1677510 - putative xanthine dehydrogenase subunit NAD%3B Oxidoreductase%3B Purine metabolism.%3B Oxidizes hypoxanthine and xanthine to uric acid. PucA subunit could exert a molybdenum cofactor recruiting function gene gene-HME7025_01477 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01477 HME7025_01478 HME7025_01478 HME7025_01478 1677462 1678592 - Cysteine desulfurase Alternative initiation%3B Alternative splicing%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Mitochondrion%3B Molybdenum cofactor biosynthesis%3B Nucleus%3B Pyridoxal phosphate%3B Transferase%3B Transit peptide.%3B Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily%3B KEGG: plu:plu0915 cysteine desulfurase gene gene-HME7025_01478 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01478 HME7025_01479 HME7025_01479 HME7025_01479 1678689 1679033 - 50S ribosomal protein L20 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit%3B Belongs to the ribosomal protein L20P family gene gene-HME7025_01479 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01479 HME7025_01480 HME7025_01480 HME7025_01480 1679116 1679310 - 50S ribosomal protein L35 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L35P family gene gene-HME7025_01480 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01480 HME7025_01481 HME7025_01481 HME7025_01481 1679398 1679958 - Translation initiation factor IF-3 Cytoplasm%3B Initiation factor%3B Protein biosynthesis.%3B IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits%2C thus enhancing the availability of 30S subunits on which protein synthesis initiation begins%3B Belongs to the IF-3 family gene gene-HME7025_01481 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01481 HME7025_01482 HME7025_01482 tarS tarS 1680076 1682016 - Threonine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Zinc.%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: pfl:PFL_6184 threonyl-tRNA synthetase gene gene-HME7025_01482 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01482 HME7025_01483 HME7025_01483 HME7025_01483 1682070 1683185 - hypothetical protein gene gene-HME7025_01483 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01483 HME7025_01484 HME7025_01484 HME7025_01484 1683152 1685962 - hypothetical protein gene gene-HME7025_01484 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01484 HME7025_01485 HME7025_01485 HME7025_01485 1685953 1687368 - Aldehyde dehydrogenase (NAD(+)) Amyloplast%3B Chloroplast%3B NAD%3B Oxidoreductase%3B Plastid%3B Stress response.%3B Oxidizes nonanal%2C propionaldehyde and acetaldehyde in vitro%2C in the following decreasing order of reactivity: nonanal%2C propionaldehyde%2C acetaldehyde%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: bty:Btoyo_3622 aldehyde dehydrogenase (NAD+) gene gene-HME7025_01485 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01485 HME7025_01486 HME7025_01486 HME7025_01486 1687374 1688123 - hypothetical protein gene gene-HME7025_01486 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01486 HME7025_01487 HME7025_01487 menE menE 1688110 1689192 - o-succinylbenzoate--CoA ligase KEGG: eol:Emtol_4005 O-succinylbenzoic acid--CoA ligase gene gene-HME7025_01487 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01487 HME7025_01488 HME7025_01488 HME7025_01488 1689276 1689725 + hypothetical protein gene gene-HME7025_01488 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01488 HME7025_01489 HME7025_01489 menB menB 1689729 1690553 + 1%2C4-dihydroxy-2-naphthoyl-CoA synthase Lyase%3B Menaquinone biosynthesis.%3B Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1%2C4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)%3B Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily%3B KEGG: sli:Slin_1753 naphthoate synthase gene gene-HME7025_01489 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01489 HME7025_01490 HME7025_01490 HME7025_01490 1690555 1690959 + Thymocyte nuclear protein Alternative splicing%3B Nucleus%3B Phosphoprotein.%3B Specifically binds 5-hydroxymethylcytosine (5hmC)%2C suggesting that it acts as a specific reader of 5hmC gene gene-HME7025_01490 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01490 HME7025_01491 HME7025_01491 HME7025_01491 1690965 1692587 + hypothetical protein gene gene-HME7025_01491 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01491 HME7025_01492 HME7025_01492 HME7025_01492 1692590 1693495 + 23S rRNA (cytosine(1962)-C(5))-methyltransferase KEGG: fte:Fluta_1231 23S rRNA (cytosine1962-C5)-methyltransferase gene gene-HME7025_01492 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01492 HME7025_01493 HME7025_01493 folD folD 1693502 1694392 - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Amino-acid biosynthesis%3B Histidine biosynthesis%3B Hydrolase%3B Methionine biosynthesis%3B Multifunctional enzyme%3B NADP%3B One-carbon metabolism%3B Oxidoreductase%3B Purine biosynthesis.%3B Catalyzes the oxidation of 5%2C10- methylenetetrahydrofolate to 5%2C10-methenyltetrahydrofolate and then the hydrolysis of 5%2C10-methenyltetrahydrofolate to 10- formyltetrahydrofolate%3B Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family%3B KEGG: bci:BCI_0122 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase gene gene-HME7025_01493 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01493 HME7025_01494 HME7025_01494 topA topA 1694415 1696904 - DNA topoisomerase DNA-binding%3B Isomerase%3B Magnesium%3B Metal-binding%3B Repeat%3B Topoisomerase%3B Zinc%3B Zinc-finger.%3B Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: fau:Fraau_3077 DNA topoisomerase I gene gene-HME7025_01494 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01494 HME7025_01495 HME7025_01495 HME7025_01495 1697013 1699262 - hypothetical protein gene gene-HME7025_01495 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01495 HME7025_01496 HME7025_01496 acnA acnA 1699487 1701751 + Aconitate hydratase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B Mitochondrion%3B Transit peptide.%3B Has no detectable activity towards cis-acontiate or cis- homoaconitate%3B Belongs to the aconitase/IPM isomerase family%3B KEGG: gap:GAPWK_2410 aconitate hydratase gene gene-HME7025_01496 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01496 HME7025_01497 HME7025_01497 prpS prpS 1701837 1702778 + Ribose-phosphate diphosphokinase ATP-binding%3B Cytoplasm%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide biosynthesis%3B Nucleotide-binding%3B Transferase.%3B Involved in the biosynthesis of ribose 1%2C5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP%3B Belongs to the ribose-phosphate pyrophosphokinase family%3B KEGG: lfc:LFE_0848 ribose-phosphate pyrophosphokinase gene gene-HME7025_01497 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01497 HME7025_01498 HME7025_01498 HME7025_01498 1702838 1703404 + 50S ribosomal protein L25 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance%3B Belongs to the ribosomal protein L25P family. CTC subfamily gene gene-HME7025_01498 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01498 HME7025_01499 HME7025_01499 hppA hppA 1703676 1705844 - Inorganic diphosphatase Calcium%3B Cell membrane%3B Hydrogen ion transport%3B Hydrolase%3B Ion transport%3B Magnesium%3B Membrane%3B Metal-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force%3B Belongs to the H(+)-translocating pyrophosphatase (TC 3. A. 10) family. K(+)-insensitive subfamily%3B KEGG: trm:JO41_07175 K(+)-stimulated pyrophosphate-energized sodium pump gene gene-HME7025_01499 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01499 HME7025_01500 HME7025_01500 HME7025_01500 1705911 1708499 - hypothetical protein gene gene-HME7025_01500 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01500 HME7025_01501 HME7025_01501 puuE puuE 1708632 1709834 + 4-aminobutyrate--2-oxoglutarate transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Cytoplasm%3B Proline biosynthesis%3B Pyridoxal phosphate%3B Transferase.%3B Catalyzes the interconversion of ornithine to glutamate semialdehyde%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily%3B KEGG: ssal:SPISAL_02400 4-aminobutyrate aminotransferase gene gene-HME7025_01501 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01501 HME7025_01502 HME7025_01502 HME7025_01502 1709831 1710154 - Thioredoxin Disulfide bond%3B Electron transport%3B Redox-active center%3B Transport.%3B Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions%3B Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene-HME7025_01502 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01502 HME7025_01503 HME7025_01503 HME7025_01503 1710219 1713782 - DNA-directed DNA polymerase Cytoplasm%3B DNA damage%3B DNA repair%3B DNA replication%3B DNA-directed DNA polymerase%3B Nucleotidyltransferase%3B Transferase.%3B DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase%3B Belongs to the DNA polymerase type-C family. DnaE2 subfamily%3B KEGG: lby:Lbys_1156 DNA polymerase III subunit alpha gene gene-HME7025_01503 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01503 HME7025_01504 HME7025_01504 HME7025_01504 1713786 1714469 - hypothetical protein gene gene-HME7025_01504 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01504 HME7025_01505 HME7025_01505 warS warS 1714586 1715557 + Tryptophan--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: orh:Ornrh_2098 tryptophanyl-tRNA synthetase gene gene-HME7025_01505 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01505 HME7025_01506 HME7025_01506 HME7025_01506 1715560 1716108 + Undecaprenyl-diphosphate phosphatase Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Lipopolysaccharide biosynthesis%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Probably removes the 4'-phosphate group from lipid A. Removal of this phosphate group confers resistance to cationic antimicrobial peptides (CAMPs)%2C inflammation-associated peptides produced by the human host. This LPS modification helps maintain the stability of this commensal bacterium in gut microbiota%3B Belongs to the lipid A LpxF 4'-phosphatase family%3B KEGG: cmr:Cycma_0631 undecaprenyl-diphosphatase gene gene-HME7025_01506 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01506 HME7025_01507 HME7025_01507 HME7025_01507 1716081 1717211 - hypothetical protein gene gene-HME7025_01507 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01507 HME7025_01508 HME7025_01508 HME7025_01508 1717243 1717590 + hypothetical protein gene gene-HME7025_01508 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01508 HME7025_01509 HME7025_01509 HME7025_01509 1717945 1719099 + hypothetical protein gene gene-HME7025_01509 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01509 HME7025_01510 HME7025_01510 HME7025_01510 1719121 1720464 + Ammonium transporter Ammonia transport%3B Cell membrane%3B Cytoplasmic vesicle%3B Endosome%3B Lysosome%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Ammonium transporter that mediates the excretion of ammonium. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development%3B Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene-HME7025_01510 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01510 HME7025_01511 HME7025_01511 mtaB mtaB 1720564 1721889 - tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing.%3B Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A)%2C leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine%3B Belongs to the methylthiotransferase family. MtaB subfamily%3B Contains 1 MTTase N-terminal domain%3B KEGG: clb:Clo1100_2685 threonylcarbamoyladenosine tRNA methylthiotransferase MtaB gene gene-HME7025_01511 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01511 HME7025_01512 HME7025_01512 glnA glnA 1721977 1722990 - Glutamate--ammonia ligase ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding.%3B Belongs to the glutamine synthetase family%3B KEGG: ant:Arnit_0262 glutamine synthetase gene gene-HME7025_01512 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01512 HME7025_01513 HME7025_01513 HME7025_01513 1723235 1725442 + Glutamate--ammonia ligase ATP-binding%3B Ligase%3B Nucleotide-binding.%3B Belongs to the glutamine synthetase family. Type 3 subfamily%3B KEGG: pbt:ING2E5B_1880 glutamine synthetase gene gene-HME7025_01513 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01513 HME7025_01514 HME7025_01514 HME7025_01514 1725454 1726011 + hypothetical protein gene gene-HME7025_01514 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01514 HME7025_01515 HME7025_01515 rsmE rsmE 1726014 1726730 + 16S rRNA (uracil(1498)-N(3))-methyltransferase KEGG: bhl:Bache_1502 16S rRNA (uracil1498-N3)-methyltransferase gene gene-HME7025_01515 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01515 HME7025_01516 HME7025_01516 HME7025_01516 1726720 1727379 + hypothetical protein gene gene-HME7025_01516 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01516 HME7025_01517 HME7025_01517 desC desC 1727469 1728230 + Stearoyl-CoA 9-desaturase KEGG: sli:Slin_1354 stearoyl-CoA desaturase (delta-9 desaturase) gene gene-HME7025_01517 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01517 HME7025_01518 HME7025_01518 dlsT dlsT 1729136 1730404 - Dihydrolipoyllysine-residue succinyltransferase Acyltransferase%3B Lipoyl%3B Transferase%3B Tricarboxylic acid cycle.%3B The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: wbr:WGLp418 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) gene gene-HME7025_01518 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01518 HME7025_01519 HME7025_01519 pncC pncC 1730407 1731660 - Nicotinamide-nucleotide amidase Belongs to the CinA family%3B KEGG: srm:SRM_01495 nicotinamide-nucleotide amidase gene gene-HME7025_01519 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01519 HME7025_01520 HME7025_01520 HME7025_01520 1731745 1732095 + hypothetical protein gene gene-HME7025_01520 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01520 HME7025_01521 HME7025_01521 HME7025_01521 1732106 1733155 + hypothetical protein gene gene-HME7025_01521 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01521 HME7025_01522 HME7025_01522 gcpE gcpE 1733348 1735363 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) 4Fe-4S%3B Iron%3B Iron-sulfur%3B Isoprene biosynthesis%3B Metal-binding%3B Oxidoreductase.%3B Converts 2C-methyl-D-erythritol 2%2C4-cyclodiphosphate (ME-2%2C4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate%3B Belongs to the IspG family%3B KEGG: lil:LA_3160 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase gene gene-HME7025_01522 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01522 HME7025_01523 HME7025_01523 HME7025_01523 1735452 1736657 - Glucose/galactose transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Intake of glucose and galactose%3B Belongs to the major facilitator superfamily. FHS transporter (TC 2. A. 1. 7) family gene gene-HME7025_01523 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01523 HME7025_01524 HME7025_01524 ligC ligC 1736664 1738016 - 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase Glycosidase%3B Hydrolase%3B NAD%3B Signal.%3B Glycosidase%3B Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily%3B KEGG: magq:MGMAQ_2671 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase gene gene-HME7025_01524 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01524 HME7025_01525 HME7025_01525 HME7025_01525 1738099 1738518 + 6-pyruvoyltetrahydropterin synthase Disease mutation%3B Lyase%3B Metal-binding%3B Phenylketonuria%3B Phosphoprotein%3B Tetrahydrobiopterin biosynthesis%3B Zinc.%3B Involved in the biosynthesis of tetrahydrobiopterin%2C an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7%2C8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin%3B Belongs to the PTPS family%3B KEGG: srd:SD10_18215 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase gene gene-HME7025_01525 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01525 HME7025_01526 HME7025_01526 gch1 gch1 1738478 1739182 + GTP cyclohydrolase I GTP-binding%3B Hydrolase%3B Metal-binding%3B Nucleotide-binding%3B One-carbon metabolism%3B Zinc.%3B Belongs to the GTP cyclohydrolase I family%3B KEGG: asl:Aeqsu_2137 GTP cyclohydrolase I gene gene-HME7025_01526 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01526 HME7025_01527 HME7025_01527 HME7025_01527 1739182 1739880 + 3-oxoacyl-[acyl-carrier-protein] reductase Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B NADP%3B Oxidoreductase.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: hni:W911_07325 3-oxoacyl-(acyl-carrier protein) reductase gene gene-HME7025_01527 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01527 HME7025_01528 HME7025_01528 HME7025_01528 1739866 1740852 - Protein p34 Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the cation diffusion facilitator (CDF) transporter (TC 2. A. 4) family gene gene-HME7025_01528 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01528 HME7025_01529 HME7025_01529 HME7025_01529 1740902 1741453 + ADP-ribose diphosphatase KEGG: lpk:LACPI_2055 ADP-ribose pyrophosphatase gene gene-HME7025_01529 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01529 HME7025_01530 HME7025_01530 surE surE 1741443 1742225 - 5'-nucleotidase Cytoplasm%3B Hydrolase%3B Metal-binding%3B Nucleotide-binding.%3B Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates%3B Belongs to the SurE nucleotidase family%3B KEGG: bhl:Bache_1253 5'-nucleotidase gene gene-HME7025_01530 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01530 HME7025_01531 HME7025_01531 HME7025_01531 1742276 1742761 + hypothetical protein gene gene-HME7025_01531 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01531 HME7025_01532 HME7025_01532 HME7025_01532 1742742 1743620 - Uridine phosphorylase Cytoplasm%3B Glycosyltransferase%3B Transferase.%3B Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)%3B Belongs to the PNP/UDP phosphorylase family%3B KEGG: bsa:Bacsa_0532 uridine phosphorylase gene gene-HME7025_01532 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01532 HME7025_01533 HME7025_01533 HME7025_01533 1743671 1744132 + hypothetical protein gene gene-HME7025_01533 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01533 HME7025_01534 HME7025_01534 ampC ampC 1744167 1745651 + Beta-lactamase Acetylation%3B Hydrolase%3B Mitochondrion%3B Transit peptide.%3B Belongs to the peptidase S12 family%3B KEGG: caq:IM40_00500 beta-lactamase class C gene gene-HME7025_01534 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01534 HME7025_01535 HME7025_01535 HME7025_01535 1745642 1746634 - UPF0176 protein Belongs to the UPF0176 family%3B Contains 1 rhodanese domain gene gene-HME7025_01535 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01535 HME7025_01536 HME7025_01536 HME7025_01536 1746673 1746756 - tRNA-Leu tRNA gene-HME7025_01536 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01536 HME7025_01537 HME7025_01537 HME7025_01537 1746833 1747207 + hypothetical protein gene gene-HME7025_01537 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01537 HME7025_01538 HME7025_01538 HME7025_01538 1747313 1748182 - Putative quercetin 2%2C3-dioxygenase Dioxygenase%3B Metal-binding%3B Oxidoreductase.%3B Putative quercetin 2%2C3-dioxygenase%3B Belongs to the pirin family gene gene-HME7025_01538 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01538 HME7025_01539 HME7025_01539 HME7025_01539 1748240 1748677 - hypothetical protein gene gene-HME7025_01539 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01539 HME7025_01540 HME7025_01540 HME7025_01540 1748679 1749638 - PhoH-like protein ATP-binding%3B Cytoplasm%3B Nucleotide-binding.%3B Belongs to the PhoH family gene gene-HME7025_01540 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01540 HME7025_01541 HME7025_01541 dnaB dnaB 1749746 1751335 + DNA helicase ATP-binding%3B Autocatalytic cleavage%3B DNA replication%3B DNA-binding%3B Endonuclease%3B Helicase%3B Hydrolase%3B Intron homing%3B Nuclease%3B Nucleotide-binding%3B Primosome%3B Protein splicing%3B Repeat.%3B Participates in initiation and elongation during chromosome replicatio%3B it exhibits DNA-dependent ATPase activity%3B Belongs to the helicase family. DnaB subfamily%3B Contains 1 DOD-type homing endonuclease domain%3B Contains 1 SF4 helicase domain%3B KEGG: sli:Slin_1916 replicative DNA helicase gene gene-HME7025_01541 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01541 HME7025_01542 HME7025_01542 rumA rumA 1751332 1752753 - 23S rRNA (uracil(1939)-C(5))-methyltransferase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily%3B Contains 1 TRAM domain%3B KEGG: fco:FCOL_07260 23S rRNA (uracil1939-C5)-methyltransferase gene gene-HME7025_01542 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01542 HME7025_01543 HME7025_01543 HME7025_01543 1752844 1753650 + 3-oxoacyl-[acyl-carrier-protein] reductase NAD%3B Oxidoreductase.%3B Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol (By similarity)%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: sod:Sant_3083 3-oxoacyl-(acyl-carrier protein) reductase gene gene-HME7025_01543 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01543 HME7025_01544 HME7025_01544 HME7025_01544 1753900 1754280 - hypothetical protein gene gene-HME7025_01544 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01544 HME7025_01545 HME7025_01545 copA copA 1754412 1756931 + Cu(+) exporting ATPase ATP-binding%3B Cell membrane%3B Hydrolase%3B Magnesium%3B Membrane%3B Metal-binding%3B Nitrogen fixation%3B Nucleotide-binding%3B Phosphoprotein%3B Transmembrane%3B Transmembrane helix.%3B FixI is a pump of a specific cation involved in symbiotic nitrogen fixation. The four proteins FixG%2C FixH%2C FixI%2C and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG. Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 1 HMA domain%3B KEGG: dfe:Dfer_5325 Cu+-exporting ATPase gene gene-HME7025_01545 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01545 HME7025_01546 HME7025_01546 HME7025_01546 1756971 1757123 + hypothetical protein gene gene-HME7025_01546 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01546 HME7025_01547 HME7025_01547 HME7025_01547 1757141 1759270 + Cytochrome-c oxidase Cell membrane%3B Copper%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B. Belongs to the heme-copper respiratory oxidase family%3B KEGG: bbd:Belba_3770 cytochrome c oxidase cbb3-type subunit I/II gene gene-HME7025_01547 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01547 HME7025_01548 HME7025_01548 HME7025_01548 1759275 1759430 + hypothetical protein gene gene-HME7025_01548 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01548 HME7025_01549 HME7025_01549 HME7025_01549 1759468 1760208 + Cbb3-type cytochrome c oxidase subunit CcoP Cell inner membrane%3B Cell membrane%3B Electron transport%3B Heme%3B Hydrogen ion transport%3B Ion transport%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Repeat%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there%2C electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity)%3B Belongs to the CcoP / FixP family%3B Contains 2 cytochrome c domains gene gene-HME7025_01549 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01549 HME7025_01550 HME7025_01550 HME7025_01550 1760228 1760440 + hypothetical protein gene gene-HME7025_01550 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01550 HME7025_01551 HME7025_01551 HME7025_01551 1760476 1761879 + Protein RdxA 4Fe-4S%3B Cell membrane%3B Electron transport%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Predicted to be involved in a redox process. Contains 2 4Fe-4S ferredoxin-type domains gene gene-HME7025_01551 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01551 HME7025_01552 HME7025_01552 HME7025_01552 1761872 1762327 + hypothetical protein gene gene-HME7025_01552 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01552 HME7025_01553 HME7025_01553 HME7025_01553 1762327 1763034 + hypothetical protein gene gene-HME7025_01553 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01553 HME7025_01554 HME7025_01554 HME7025_01554 1763006 1764073 - Protein RcaC Activator%3B DNA-binding%3B Phosphoprotein%3B Repeat%3B Transcription%3B Transcription regulation%3B Two-component regulatory system.%3B Required for chromatic adaptation. Thought to be a positive regulator of phycobiliproteins. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 3 response regulatory domains gene gene-HME7025_01554 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01554 HME7025_01555 HME7025_01555 HME7025_01555 1764063 1765286 - Protein-histidine pros-kinase c-di-GMP%3B Heme%3B Hydrolase%3B Iron%3B Magnesium%3B Metal-binding%3B Repeat%3B Sensory transduction%3B Transcription%3B Transcription regulation.%3B Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels%2C in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic- di-GMP is a second messenger which controls cell surface- associated traits in bacteria. Has very poor PDE activity on cAMP (PubMed:15995192) but is not active with cGMP%2C bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate (PubMed:11970957). Via its PDE activity on c-di-GMP%2C DosP regulates biofilm formation through the repression of transcription of the csgBAC operon%2C which encodes curli structural subunits%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 2 PAS (PER-ARNT-SIM) domains%3B KEGG: azo:azo1492 protein-histidine pros-kinase gene gene-HME7025_01555 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01555 HME7025_01556 HME7025_01556 HME7025_01556 1765340 1767529 - Penicillin amidase Antibiotic resistance%3B Hydrolase%3B Periplasm%3B Signal%3B Zymogen.%3B Catalyzes the deacylation of 7 beta-(4- carboxybutanamido)cephalosporanic acid (glutaryl-7- aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA). Can not efficiently use cephalosporin C (CPC)%2C penicillin G%2C or ampicillin as substrates%3B Belongs to the peptidase S45 family%3B KEGG: btw:BF38_4451 penicillin amidase gene gene-HME7025_01556 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01556 HME7025_01557 HME7025_01557 HME7025_01557 1767714 1771103 + Quinoprotein glucose dehydrogenase (PQQ%2C quinone) KEGG: rba:RB1988 quinoprotein glucose dehydrogenase gene gene-HME7025_01557 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01557 HME7025_01558 HME7025_01558 HME7025_01558 1771132 1771497 + hypothetical protein gene gene-HME7025_01558 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01558 HME7025_01559 HME7025_01559 HME7025_01559 1771638 1773242 + C4-dicarboxylic acid transporter DauA Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH%3B Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain gene gene-HME7025_01559 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01559 HME7025_01560 HME7025_01560 HME7025_01560 1773335 1775839 + UPF0753 protein Belongs to the UPF0753 family gene gene-HME7025_01560 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01560 HME7025_01561 HME7025_01561 nuoL nuoL 1775844 1777709 + NADH:ubiquinone reductase (H(+)-translocating) Electron transport%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone.%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)%3B Belongs to the complex I subunit 5 family%3B KEGG: aeh:Mlg_1959 NADH-quinone oxidoreductase subunit L gene gene-HME7025_01561 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01561 HME7025_01562 HME7025_01562 srfJ srfJ 1777841 1779247 + Glucosylceramidase Glycoprotein%3B Glycosidase%3B Hydrolase%3B Secreted%3B Signal.%3B Endoglucanase that has highest activity on the linear beta-1%2C6-glucan pustulan and lower activity against laminarin (beta-1%2C3-glucans with beta-1%2C6-branches). Is active on C. albicans cell walls allowing the release of a previously described cell wall proteins%3B Belongs to the glycosyl hydrolase 30 family%3B KEGG: mai:MICA_2006 glucosylceramidase gene gene-HME7025_01562 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01562 HME7025_01563 HME7025_01563 HME7025_01563 1779244 1780614 + Inositol 2-dehydrogenase KEGG: bml:BMA10229_A0430 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_01563 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01563 HME7025_01564 HME7025_01564 HME7025_01564 1780628 1782022 + Sialate O-acetylesterase KEGG: saci:Sinac_6998 sialate O-acetylesterase gene gene-HME7025_01564 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01564 HME7025_01565 HME7025_01565 HME7025_01565 1782052 1784532 + hypothetical protein gene gene-HME7025_01565 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01565 HME7025_01566 HME7025_01566 HME7025_01566 1784529 1786619 + Penicillin amidase Hydrolase%3B Periplasm%3B Quorum sensing%3B Signal%3B Zymogen.%3B Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL)%2C releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length) (By similarity)%3B Belongs to the peptidase S45 family%3B KEGG: bmx:BMS_2072 penicillin amidase gene gene-HME7025_01566 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01566 HME7025_01567 HME7025_01567 paaH paaH 1786728 1787570 - 3-hydroxybutyryl-CoA dehydrogenase Cytoplasm%3B NAD%3B Oxidoreductase%3B Plasmid.%3B Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine%3B Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily%3B KEGG: dal:Dalk_2639 3-hydroxybutyryl-CoA dehydrogenase gene gene-HME7025_01567 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01567 HME7025_01568 HME7025_01568 HME7025_01568 1787572 1788597 - Medium-chain acyl-CoA dehydrogenase Acetylation%3B FAD%3B Fatty acid metabolism%3B Flavoprotein%3B Lipid metabolism%3B Oxidoreductase%3B Peroxisome.%3B Involved with IBR1 and IBR10 in the peroxisomal beta- oxidation of indole-3-butyric acid (IBA) to form indole-3-acetic acid (IAA)%2C a biologically active auxin (PubMed:20562230). May be responsible for catalyzing the first step in IBA-CoA beta- oxidation (PubMed:17277896). May play a role in defense response to pathogenic bacteria (PubMed:23906045)%3B Belongs to the acyl-CoA dehydrogenase family%3B KEGG: sly:101261954 acyl-CoA dehydrogenase gene gene-HME7025_01568 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01568 HME7025_01569 HME7025_01569 HME7025_01569 1788594 1789805 - Medium-chain acyl-CoA dehydrogenase Acetylation%3B Alternative splicing%3B FAD%3B Flavoprotein%3B Oxidoreductase%3B Polymorphism.%3B Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA%3B Belongs to the acyl-CoA dehydrogenase family%3B KEGG: npe:Natpe_3552 acyl-CoA dehydrogenase gene gene-HME7025_01569 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01569 HME7025_01570 HME7025_01570 idnO idnO 1789811 1790611 - Gluconate 5-dehydrogenase Carbohydrate metabolism%3B NADP%3B Oxidoreductase.%3B Catalyzes the NADP dependent reduction of L-sorbose to D-glucitol%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: oan:Oant_3756 gluconate 5-dehydrogenase gene gene-HME7025_01570 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01570 HME7025_01571 HME7025_01571 cryZ cryZ 1790689 1791654 + NADPH:quinone reductase Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Mitochondrion%3B NADP%3B Oxidoreductase%3B Transit peptide.%3B Oxidoreductase with a preference for short and medium chain substrates%2C including trans-2-hexenoyl-CoA (C6)%2C trans-2- decenoyl-CoA (C10)%2C and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity)%3B Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily%3B KEGG: tfu:Tfu_0360 NADPH2:quinone reductase gene gene-HME7025_01571 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01571 HME7025_01572 HME7025_01572 HME7025_01572 1791817 1793001 - hypothetical protein gene gene-HME7025_01572 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01572 HME7025_01573 HME7025_01573 HME7025_01573 1793024 1793404 - Ribonuclease Z KEGG: awo:Awo_c33060 ribonuclease Z gene gene-HME7025_01573 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01573 HME7025_01574 HME7025_01574 HME7025_01574 1793569 1795614 + hypothetical protein gene gene-HME7025_01574 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01574 HME7025_01575 HME7025_01575 HME7025_01575 1795588 1796721 - hypothetical protein gene gene-HME7025_01575 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01575 HME7025_01576 HME7025_01576 HME7025_01576 1796793 1798031 - hypothetical protein gene gene-HME7025_01576 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01576 HME7025_01577 HME7025_01577 HME7025_01577 1798302 1799153 - hypothetical protein gene gene-HME7025_01577 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01577 HME7025_01578 HME7025_01578 HME7025_01578 1799229 1800602 - Bacterial leucyl aminopeptidase Carboxypeptidase%3B Endoplasmic reticulum%3B Glycoprotein%3B Golgi apparatus%3B Hydrolase%3B Lysosome%3B Metal-binding%3B Metalloprotease%3B Protease%3B Secreted%3B Signal%3B Zinc%3B Zymogen.%3B Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity)%3B Belongs to the peptidase M28 family%3B KEGG: bur:Bcep18194_B0596 bacterial leucyl aminopeptidase gene gene-HME7025_01578 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01578 HME7025_01579 HME7025_01579 HME7025_01579 1800820 1801929 + hypothetical protein gene gene-HME7025_01579 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01579 HME7025_01580 HME7025_01580 HME7025_01580 1801929 1803134 + Gallate transporter Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Transporter that specifically mediates the uptake of gallate%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene-HME7025_01580 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01580 HME7025_01581 HME7025_01581 adhP adhP 1803131 1804129 + Alcohol dehydrogenase Acetylation%3B Cytoplasm%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Zinc.%3B Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: raq:Rahaq2_2894 alcohol dehydrogenase%2C propanol-preferring gene gene-HME7025_01581 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01581 HME7025_01582 HME7025_01582 HME7025_01582 1804319 1804747 + hypothetical protein gene gene-HME7025_01582 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01582 HME7025_01583 HME7025_01583 HME7025_01583 1804902 1805972 + uncharacterized protein Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene-HME7025_01583 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01583 HME7025_01584 HME7025_01584 HME7025_01584 1805996 1809199 + Efflux pump membrane transporter BepG Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B May contribute to resistance to some drugs%2C such as deoxycholate%2C sodium dodecyl sulfate and nalidixic acid%2C in the absence of BepD and BepE%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene-HME7025_01584 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01584 HME7025_01585 HME7025_01585 HME7025_01585 1809186 1810619 + Cation efflux system protein CusC Cell outer membrane%3B Ion transport%3B Lipoprotein%3B Membrane%3B Palmitate%3B Porin%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver (By similarity)%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene-HME7025_01585 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01585 HME7025_01586 HME7025_01586 HME7025_01586 1810752 1811018 - hypothetical protein gene gene-HME7025_01586 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01586 HME7025_01587 HME7025_01587 HME7025_01587 1811703 1812245 + hypothetical protein gene gene-HME7025_01587 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01587 HME7025_01588 HME7025_01588 metE metE 1812358 1814673 - 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Amino-acid biosynthesis%3B Metal-binding%3B Methionine biosynthesis%3B Methyltransferase%3B Repeat%3B Transferase%3B Zinc.%3B Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation%3B Belongs to the vitamin-B12 independent methionine synthase family%3B KEGG: mad:HP15_457 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase gene gene-HME7025_01588 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01588 HME7025_01589 HME7025_01589 HME7025_01589 1815248 1815320 - tRNA-Lys tRNA gene-HME7025_01589 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01589 HME7025_01590 HME7025_01590 HME7025_01590 1815455 1816192 + hypothetical protein gene gene-HME7025_01590 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01590 HME7025_01591 HME7025_01591 holA holA 1816189 1817238 - DNA-directed DNA polymerase KEGG: mtt:Ftrac_0323 DNA polymerase III subunit delta gene gene-HME7025_01591 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01591 HME7025_01592 HME7025_01592 slyD slyD 1817361 1817876 + Peptidylprolyl isomerase Chaperone%3B Cytoplasm%3B Isomerase%3B Metal-binding%3B Nickel%3B Rotamase.%3B Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides%2C which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction (By similarity)%3B Also involved in hydrogenase metallocenter assembly%2C probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain%2C but not PPIase activity (By similarity)%3B Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: dfe:Dfer_1067 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD gene gene-HME7025_01592 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01592 HME7025_01593 HME7025_01593 HME7025_01593 1817978 1818415 - dCMP deaminase Allosteric enzyme%3B Hydrolase%3B Metal-binding%3B Nucleotide biosynthesis%3B Zinc.%3B Supplies the nucleotide substrate for thymidylate synthetase. Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: sth:STH80 dCMP deaminase gene gene-HME7025_01593 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01593 HME7025_01594 HME7025_01594 HME7025_01594 1819030 1819368 + UPF0213 protein Belongs to the UPF0213 family%3B Contains 1 GIY-YIG domain gene gene-HME7025_01594 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01594 HME7025_01595 HME7025_01595 HME7025_01595 1819732 1819808 - tRNA-Met tRNA gene-HME7025_01595 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01595 HME7025_01596 HME7025_01596 HME7025_01596 1819972 1820364 + hypothetical protein gene gene-HME7025_01596 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01596 HME7025_01597 HME7025_01597 HME7025_01597 1820366 1821826 + hypothetical protein gene gene-HME7025_01597 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01597 HME7025_01598 HME7025_01598 HME7025_01598 1821904 1822179 + 30S ribosomal protein S15 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA%3B Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome%3B Belongs to the ribosomal protein S15P family gene gene-HME7025_01598 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01598 HME7025_01599 HME7025_01599 HME7025_01599 1822297 1824444 + Polyribonucleotide nucleotidyltransferase Cytoplasm%3B Magnesium%3B Metal-binding%3B Nucleotidyltransferase%3B RNA-binding%3B Transferase.%3B Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction%3B Belongs to the polyribonucleotide nucleotidyltransferase family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain%3B KEGG: dfe:Dfer_1057 polyribonucleotide nucleotidyltransferase gene gene-HME7025_01599 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01599 HME7025_01600 HME7025_01600 HME7025_01600 1824504 1825367 + RNA polymerase sigma factor RpoS Cytoplasm%3B DNA-binding%3B Sigma factor%3B Transcription%3B Transcription regulation.%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response%3B Belongs to the sigma-70 factor family. RpoS subfamily gene gene-HME7025_01600 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01600 HME7025_01601 HME7025_01601 menD menD 1825402 1827090 + 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acidsynthase Magnesium%3B Manganese%3B Menaquinone biosynthesis%3B Metal-binding%3B Thiamine pyrophosphate%3B Transferase.%3B Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)%3B Belongs to the TPP enzyme family. MenD subfamily%3B KEGG: yru:BD65_831 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase gene gene-HME7025_01601 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01601 HME7025_01602 HME7025_01602 HME7025_01602 1827076 1827831 - Serine/threonine-protein phosphatase Acetylation%3B Alzheimer disease%3B Amyloid%3B Amyloidosis%3B Cytoplasm%3B DNA damage%3B DNA repair%3B Hydrolase%3B Lipid-binding%3B Magnesium%3B Manganese%3B Membrane%3B Metal-binding%3B Neurodegeneration%3B Nucleus%3B Protein phosphatase%3B Repeat%3B TPR repeat.%3B Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E%2C ASK1/MAP3K5%2C PRKDC and RAF1%2C the nuclear receptors NR3C1%2C PPARG%2C ESR1 and ESR2%2C SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes%2C including apoptosis%2C differentiation%2C DNA damage response%2C cell survival%2C regulation of ion channels or circadian rhythms%2C in response to steroid and thyroid hormones%2C calcium%2C fatty acids%2C TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through%2C for instance%2C the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis%2C mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms%2C through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation%2C may play a role in the regulation of ions channels such as KCNH2%3B Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily%3B Contains 3 TPR repeats gene gene-HME7025_01602 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01602 HME7025_01603 HME7025_01603 HME7025_01603 1827922 1828362 + Peptidylprolyl isomerase Isomerase%3B Rotamase.%3B PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)%3B Belongs to the cyclophilin-type PPIase family%3B Contains 1 PPIase cyclophilin-type domain%3B KEGG: cvi:CV_3184 peptidylprolyl isomerase gene gene-HME7025_01603 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01603 HME7025_01604 HME7025_01604 HME7025_01604 1828399 1828602 + hypothetical protein gene gene-HME7025_01604 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01604 HME7025_01605 HME7025_01605 HME7025_01605 1828599 1830398 - hypothetical protein gene gene-HME7025_01605 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01605 HME7025_01606 HME7025_01606 HME7025_01606 1830579 1833602 + hypothetical protein gene gene-HME7025_01606 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01606 HME7025_01607 HME7025_01607 HME7025_01607 1833609 1835306 + hypothetical protein gene gene-HME7025_01607 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01607 HME7025_01608 HME7025_01608 HME7025_01608 1835290 1836345 + hypothetical protein gene gene-HME7025_01608 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01608 HME7025_01609 HME7025_01609 HME7025_01609 1836350 1837243 + hypothetical protein gene gene-HME7025_01609 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01609 HME7025_01610 HME7025_01610 folC folC 1837260 1838549 + Dihydrofolate synthase ATP-binding%3B Ligase%3B Mitochondrion%3B Nucleotide-binding%3B One-carbon metabolism.%3B Conversion of folates to polyglutamate derivatives. Belongs to the folylpolyglutamate synthase family%3B KEGG: ccm:Ccan_07130 dihydrofolate synthase / folylpolyglutamate synthase gene gene-HME7025_01610 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01610 HME7025_01611 HME7025_01611 trmB trmB 1838553 1839212 + tRNA (guanine(46)-N(7))-methyltransferase Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing.%3B Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family%3B KEGG: fae:FAES_3166 tRNA (guanine-N7-)-methyltransferase gene gene-HME7025_01611 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01611 HME7025_01612 HME7025_01612 gapA gapA 1839259 1840251 - Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Cytoplasm%3B DNA-binding%3B Glutathionylation%3B Glycolysis%3B NAD%3B Nucleus%3B Oxidoreductase%3B S-nitrosylation%3B Stress response%3B Ubl conjugation.%3B Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA)%2C a multifunctional stress signaling lipid in plants. Required for full fertility. Binds DNA in vitro%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: syne:Syn6312_2116 glyceraldehyde 3-phosphate dehydrogenase gene gene-HME7025_01612 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01612 HME7025_01613 HME7025_01613 dapD dapD 1840752 1841570 + 2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase Acyltransferase%3B Amino-acid biosynthesis%3B Cytoplasm%3B Diaminopimelate biosynthesis%3B Lysine biosynthesis%3B Repeat%3B Transferase.%3B Belongs to the transferase hexapeptide repeat family%3B KEGG: fco:FCOL_06165 2%2C3%2C4%2C5-tetrahydropyridine-2-carboxylate N-succinyltransferase gene gene-HME7025_01613 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01613 HME7025_01614 HME7025_01614 HME7025_01614 1841620 1842462 + Conserved virulence factor Virulence.%3B Contributes to the expression of virulence factors and to pathogenicity. Involved in the production of hemolysin%2C DNase%2C protease and protein A (By similarity)%3B Belongs to the CvfB family gene gene-HME7025_01614 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01614 HME7025_01615 HME7025_01615 HME7025_01615 1842540 1843043 + hypothetical protein gene gene-HME7025_01615 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01615 HME7025_01616 HME7025_01616 HME7025_01616 1843436 1843903 + hypothetical protein gene gene-HME7025_01616 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01616 HME7025_01617 HME7025_01617 HME7025_01617 1843900 1844580 + Response regulator ArlR Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system.%3B Member of the two-component regulatory system ArlS/ArlR%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene-HME7025_01617 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01617 HME7025_01618 HME7025_01618 cusS cusS 1844587 1845960 + Histidine kinase ATP-binding%3B Cadmium%3B Cell inner membrane%3B Cell membrane%3B Cobalt%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Plasmid%3B Signal%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Zinc.%3B Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt%2C zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: gur:Gura_1987 two-component system%2C OmpR family%2C heavy metal sensor histidine kinase CusS gene gene-HME7025_01618 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01618 HME7025_01619 HME7025_01619 HME7025_01619 1846068 1846868 - hypothetical protein gene gene-HME7025_01619 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01619 HME7025_01620 HME7025_01620 HME7025_01620 1846892 1847317 - hypothetical protein gene gene-HME7025_01620 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01620 HME7025_01621 HME7025_01621 HME7025_01621 1847757 1849196 - uncharacterized protein Repeat%3B TPR repeat.%3B In the C-terminal sectio%3B belongs to the protein sulfotransferase family%3B Contains 8 TPR repeats gene gene-HME7025_01621 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01621 HME7025_01622 HME7025_01622 gyrA gyrA 1849251 1851836 - DNA topoisomerase (ATP-hydrolyzing) ATP-binding%3B Cytoplasm%3B DNA-binding%3B Isomerase%3B Nucleotide-binding%3B Topoisomerase.%3B DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the topoisomerase GyrA/ParC subunit family%3B KEGG: psd:DSC_07900 DNA gyrase subunit A gene gene-HME7025_01622 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01622 HME7025_01623 HME7025_01623 HME7025_01623 1852398 1854173 + hypothetical protein gene gene-HME7025_01623 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01623 HME7025_01624 HME7025_01624 HME7025_01624 1854170 1855192 - HTH-type transcriptional regulator IdnR DNA-binding%3B Gluconate utilization%3B Transcription%3B Transcription regulation.%3B Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate%3B Contains 1 HTH lacI-type DNA-binding domain gene gene-HME7025_01624 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01624 HME7025_01625 HME7025_01625 folB folB 1855234 1855596 - Dihydroneopterin aldolase KEGG: nso:NIASO_05535 dihydroneopterin aldolase gene gene-HME7025_01625 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01625 HME7025_01626 HME7025_01626 HME7025_01626 1855598 1856515 - Septum site-determining protein DivIVA Cell cycle%3B Cell division%3B Coiled coil%3B Cytoplasm%3B Septation%3B Sporulation.%3B May act as a pilot protein%2C directing MinCD to the polar septation sites or by inhibiting MinCD at the midcell site of division. Required for polar localization of the chromosome during sporulation%3B Belongs to the DivIVA family gene gene-HME7025_01626 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01626 HME7025_01627 HME7025_01627 HME7025_01627 1856539 1857441 - hypothetical protein gene gene-HME7025_01627 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01627 HME7025_01628 HME7025_01628 HME7025_01628 1857496 1858125 + hypothetical protein gene gene-HME7025_01628 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01628 HME7025_01629 HME7025_01629 HME7025_01629 1858122 1858955 - F-box only protein 21 Alternative splicing%3B Polymorphism%3B Ubl conjugation pathway.%3B Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex%3B Contains 1 F-box domain gene gene-HME7025_01629 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01629 HME7025_01630 HME7025_01630 HME7025_01630 1859109 1860128 + UDP-glucose 4-epimerase Carbohydrate metabolism%3B Galactose metabolism%3B Isomerase%3B NAD.%3B Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: eco:b0759 UDP-glucose 4-epimerase gene gene-HME7025_01630 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01630 HME7025_01631 HME7025_01631 HME7025_01631 1860133 1861188 + dTDP-glucose 4%2C6-dehydratase Lyase%3B NAD.%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily%3B KEGG: gni:GNIT_2535 dTDP-glucose 4%2C6-dehydratase gene gene-HME7025_01631 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01631 HME7025_01632 HME7025_01632 rfbA rfbA 1861191 1862051 + Glucose-1-phosphate thymidylyltransferase Antibiotic biosynthesis%3B Magnesium%3B Metal-binding%3B Nucleotidyltransferase%3B Transferase.%3B Catalyzes the formation of dTDP-glucose%2C from dTTP and glucose 1-phosphate in the novobiocin biosynthesis pathway%2C an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Belongs to the glucose-1-phosphate thymidylyltransferase family%3B KEGG: eco:b3789 glucose-1-phosphate thymidylyltransferase gene gene-HME7025_01632 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01632 HME7025_01633 HME7025_01633 HME7025_01633 1862048 1863220 - hypothetical protein gene gene-HME7025_01633 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01633 HME7025_01634 HME7025_01634 f6h1 f6h1 1863225 1864190 - putative 2-oxoglutarate-dependent dioxygenase AOP1 Dioxygenase%3B Iron%3B Metal-binding%3B Oxidoreductase.%3B Probable 2-oxoglutarate-dependent dioxygenase that may be involved in glucosinolates biosynthesis. May play a role in the production of aliphatic glucosinolates (By similarity)%3B Belongs to the iron/ascorbate-dependent oxidoreductase family%3B Contains 1 Fe2OG dioxygenase domain%3B KEGG: eus:EUTSA_v10023159mg feruloyl-CoA ortho-hydroxylase%3B With 2-oxoglutarate as one donor%2C and incorporation of one atom each of oxygen into both donors gene gene-HME7025_01634 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01634 HME7025_01635 HME7025_01635 HME7025_01635 1864194 1864901 - Superoxide dismutase Iron%3B Metal-binding%3B Oxidoreductase.%3B Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family%3B KEGG: xfa:XF1921 superoxide dismutase%2C Fe-Mn family gene gene-HME7025_01635 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01635 HME7025_01636 HME7025_01636 HME7025_01636 1864919 1865530 - Recombination protein RecR DNA damage%3B DNA recombination%3B DNA repair%3B Metal-binding%3B Zinc%3B Zinc-finger.%3B May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO%3B Belongs to the RecR family%3B Contains 1 Toprim domain gene gene-HME7025_01636 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01636 HME7025_01637 HME7025_01637 HME7025_01637 1865534 1865866 - hypothetical protein gene gene-HME7025_01637 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01637 HME7025_01638 HME7025_01638 HME7025_01638 1865930 1867366 + Sodium/iodide cotransporter Glycoprotein%3B Ion transport%3B Membrane%3B Phosphoprotein%3B Sodium%3B Sodium transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Mediates iodide uptake in the thyroid gland. Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene-HME7025_01638 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01638 HME7025_01639 HME7025_01639 HME7025_01639 1867423 1867986 - UPF0312 protein Periplasm%3B Signal.%3B Belongs to the UPF0312 family. Type 1 subfamily gene gene-HME7025_01639 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01639 HME7025_01640 HME7025_01640 HME7025_01640 1868121 1870883 - hypothetical protein gene gene-HME7025_01640 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01640 HME7025_01641 HME7025_01641 HME7025_01641 1871341 1872543 + hypothetical protein gene gene-HME7025_01641 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01641 HME7025_01642 HME7025_01642 HME7025_01642 1872717 1873775 + hypothetical protein gene gene-HME7025_01642 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01642 HME7025_01643 HME7025_01643 HME7025_01643 1873765 1874859 + hypothetical protein gene gene-HME7025_01643 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01643 HME7025_01644 HME7025_01644 HME7025_01644 1874852 1875307 + hypothetical protein gene gene-HME7025_01644 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01644 HME7025_01645 HME7025_01645 HME7025_01645 1875314 1877443 + hypothetical protein gene gene-HME7025_01645 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01645 HME7025_01646 HME7025_01646 HME7025_01646 1877658 1878533 + hypothetical protein gene gene-HME7025_01646 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01646 HME7025_01647 HME7025_01647 HME7025_01647 1878505 1878684 - hypothetical protein gene gene-HME7025_01647 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01647 HME7025_01648 HME7025_01648 HME7025_01648 1878770 1879297 + hypothetical protein gene gene-HME7025_01648 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01648 HME7025_01649 HME7025_01649 HME7025_01649 1879692 1880987 - hypothetical protein gene gene-HME7025_01649 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01649 HME7025_01650 HME7025_01650 HME7025_01650 1881306 1882739 + hypothetical protein gene gene-HME7025_01650 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01650 HME7025_01651 HME7025_01651 HME7025_01651 1882801 1883181 - uncharacterized protein gene gene-HME7025_01651 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01651 HME7025_01652 HME7025_01652 HME7025_01652 1883252 1884436 - hypothetical protein gene gene-HME7025_01652 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01652 HME7025_01653 HME7025_01653 HME7025_01653 1884513 1885709 - hypothetical protein gene gene-HME7025_01653 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01653 HME7025_01654 HME7025_01654 HME7025_01654 1886182 1886253 - tRNA-Glu tRNA gene-HME7025_01654 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01654 HME7025_01655 HME7025_01655 glgB glgB 1886382 1888280 + 1%2C4-alpha-glucan branching enzyme Carbohydrate metabolism%3B Glycogen biosynthesis%3B Glycogen metabolism%3B Glycosyltransferase%3B Transferase.%3B Catalyzes the formation of the alpha-1%2C6-glucosidic linkages in glycogen by scission of a 1%2C4-alpha-linked oligosaccharide from growing alpha-1%2C4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1%2C6 position%3B Belongs to the glycosyl hydrolase 13 family. GlgB subfamily%3B KEGG: psn:Pedsa_0518 1%2C4-alpha-glucan branching enzyme gene gene-HME7025_01655 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01655 HME7025_01656 HME7025_01656 HME7025_01656 1888481 1888888 - hypothetical protein gene gene-HME7025_01656 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01656 HME7025_01657 HME7025_01657 pyrF pyrF 1889124 1889948 - Orotidine-5'-phosphate decarboxylase Decarboxylase%3B Lyase%3B Pyrimidine biosynthesis.%3B Belongs to the OMP decarboxylase family. Type 2 subfamily%3B KEGG: fps:FP0537 orotidine-5'-phosphate decarboxylase gene gene-HME7025_01657 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01657 HME7025_01658 HME7025_01658 HME7025_01658 1890062 1890601 + dTDP-4-dehydrorhamnose 3%2C5-epimerase Isomerase.%3B Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose%2C forming dTDP-6-deoxy-L-lyxo-4- hexulose%3B Belongs to the dTDP-4-dehydrorhamnose 3%2C5-epimerase family%3B KEGG: age:AA314_04353 dTDP-4-dehydrorhamnose 3%2C5-epimerase gene gene-HME7025_01658 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01658 HME7025_01659 HME7025_01659 HME7025_01659 1890635 1891174 + Uracil phosphoribosyltransferase Glycosyltransferase%3B RNA-binding%3B Transcription%3B Transcription regulation%3B Transcription termination%3B Transferase.%3B Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator%2C leading to a reduced expression of downstream genes%3B Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily%3B KEGG: cly:Celly_0177 pyrimidine operon attenuation protein / uracil phosphoribosyltransferase gene gene-HME7025_01659 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01659 HME7025_01660 HME7025_01660 pyrB pyrB 1891185 1892102 + Aspartate carbamoyltransferase Pyrimidine biosynthesis%3B Transferase.%3B Belongs to the ATCase/OTCase family%3B KEGG: nso:NIASO_04035 aspartate carbamoyltransferase catalytic subunit gene gene-HME7025_01660 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01660 HME7025_01661 HME7025_01661 HME7025_01661 1892082 1893104 - hypothetical protein gene gene-HME7025_01661 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01661 HME7025_01662 HME7025_01662 HME7025_01662 1893171 1894400 + putative zinc protease Hydrolase%3B Metal-binding%3B Metalloprotease%3B Protease%3B Zinc.%3B Belongs to the peptidase M16 family%3B KEGG: pzu:PHZ_c3416 zinc protease%3B Metalloendopeptidases gene gene-HME7025_01662 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01662 HME7025_01663 HME7025_01663 HME7025_01663 1894512 1895534 + Coproporphyrinogen dehydrogenase Belongs to the anaerobic coproporphyrinogen-III oxidase family%3B KEGG: aal:EP13_11150 oxygen-independent coproporphyrinogen III oxidase gene gene-HME7025_01663 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01663 HME7025_01664 HME7025_01664 mtgA mtgA 1895590 1896384 + Monofunctional biosynthetic peptidoglycan transglycosylase Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Peptidoglycan synthesis%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Cell wall formation%3B Belongs to the glycosyltransferase 51 family%3B KEGG: pfl:PFL_5853 monofunctional biosynthetic peptidoglycan transglycosylase%3B Hexosyltransferases gene gene-HME7025_01664 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01664 HME7025_01665 HME7025_01665 HME7025_01665 1896402 1896728 - Alkyltransferase-like protein DNA damage%3B DNA repair%3B DNA-binding.%3B Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts. The DNA is bent%2C the damaged base is rotated out of the DNA duplex into a hydrophobic binding pocket (nucleotide flipping)%2C with Arg-39 donating a hydrogen bond to the orphaned cytosine to stabilize the extrahelical DNA conformation. This structural change in DNA presents the lesion to the nucleotide excision repair (NER) pathway (PubMed:16679453%2C PubMed:19516334%2C PubMed:23112169). The affinity for O(6)-alkylguanine adducts increases with the size of the alkyl group. Low affinity small O(6)-alkylguanines are directed to the global genome repair pathway of NER via rhp7-rhp16 and rhp41-rhp23%2C while strong binding to bulky O(6)-alkylguanines stalls the transcription machinery and diverts the damage to the transcription-coupled repair pathway of NER via rhp26 (PubMed:22658721)%3B Belongs to the MGMT family. ATL subfamily gene gene-HME7025_01665 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01665 HME7025_01666 HME7025_01666 HME7025_01666 1896786 1897361 - hypothetical protein gene gene-HME7025_01666 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01666 HME7025_01667 HME7025_01667 HME7025_01667 1897460 1899094 + hypothetical protein gene gene-HME7025_01667 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01667 HME7025_01668 HME7025_01668 HME7025_01668 1899091 1899732 - Caffeoyl-CoA O-methyltransferase Alternative initiation%3B Catecholamine metabolism%3B Cell membrane%3B Cytoplasm%3B Magnesium%3B Membrane%3B Metal-binding%3B Methyltransferase%3B Neurotransmitter degradation%3B Phosphoprotein%3B S-adenosyl-L-methionine%3B Signal-anchor%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the O-methylation%2C and thereby the inactivation%2C of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs%2C like L-DOPA%2C alpha-methyl DOPA and isoproterenol (By similarity)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family%3B KEGG: coc:Coch_2051 caffeoyl-CoA O-methyltransferase gene gene-HME7025_01668 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01668 HME7025_01669 HME7025_01669 coq3 coq3 1899737 1900513 - Polyprenyldihydroxybenzoate methyltransferase Acetylation%3B Membrane%3B Methyltransferase%3B Mitochondrion%3B Mitochondrion inner membrane%3B S-adenosyl-L-methionine%3B Transferase%3B Transit peptide%3B Ubiquinone biosynthesis.%3B O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family%3B KEGG: hst:105181953 polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase gene gene-HME7025_01669 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01669 HME7025_01670 HME7025_01670 HME7025_01670 1900619 1901179 + hypothetical protein gene gene-HME7025_01670 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01670 HME7025_01671 HME7025_01671 HME7025_01671 1901172 1901471 + uncharacterized protein gene gene-HME7025_01671 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01671 HME7025_01672 HME7025_01672 HME7025_01672 1901570 1902163 + Alpha-ketoglutarate-dependent dioxygenase alkB like protein Cytoplasm%3B Dioxygenase%3B DNA damage%3B DNA repair%3B Iron%3B Metal-binding%3B Nucleus%3B Oxidoreductase.%3B Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3%2C which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen%2C alpha-ketoglutarate and iron%3B Belongs to the alkB family%3B Contains 1 Fe2OG dioxygenase domain%3B With 2-oxoglutarate as one donor%2C and incorporation of one atom each of oxygen into both donors gene gene-HME7025_01672 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01672 HME7025_01673 HME7025_01673 HME7025_01673 1902234 1903025 + 23S rRNA (guanosine(2251)-2'-O)-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase.%3B Specifically methylates the ribose of guanosine 2251 in 23S rRNA%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily%3B KEGG: rsi:Runsl_1513 23S rRNA (guanosine2251-2'-O)-methyltransferase gene gene-HME7025_01673 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01673 HME7025_01674 HME7025_01674 HME7025_01674 1903026 1903841 - putative oxidoreductase Oxidoreductase.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pmu:PM0579 null%3B Oxidoreductases gene gene-HME7025_01674 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01674 HME7025_01675 HME7025_01675 pth1 pth1 1903852 1904412 + Aminoacyl-tRNA hydrolase Cytoplasm%3B Hydrolase.%3B The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis%3B Belongs to the PTH family%3B KEGG: csc:Csac_1205 peptidyl-tRNA hydrolase%2C PTH1 family gene gene-HME7025_01675 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01675 HME7025_01676 HME7025_01676 HME7025_01676 1904662 1905138 + hypothetical protein gene gene-HME7025_01676 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01676 HME7025_01677 HME7025_01677 marS marS 1905376 1907406 - Methionine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B RNA-binding%3B tRNA-binding%3B Zinc.%3B Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation%3B Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily%3B Contains 1 tRNA-binding domain%3B KEGG: ppn:Palpr_1786 methionyl-tRNA synthetase gene gene-HME7025_01677 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01677 HME7025_01678 HME7025_01678 HME7025_01678 1907491 1907742 + 30S ribosomal protein S21 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein S21P family gene gene-HME7025_01678 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01678 HME7025_01679 HME7025_01679 HME7025_01679 1907779 1908657 + Tyrosine recombinase XerC Cell cycle%3B Cell division%3B Chromosome partition%3B Cytoplasm%3B DNA integration%3B DNA recombination%3B DNA-binding.%3B Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerC subfamily gene gene-HME7025_01679 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01679 HME7025_01680 HME7025_01680 HME7025_01680 1908654 1909589 - Homoserine kinase Amino-acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Threonine biosynthesis%3B Transferase.%3B Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate%3B Belongs to the GHMP kinase family. Homoserine kinase subfamily%3B KEGG: eao:BD94_2258 homoserine kinase gene gene-HME7025_01680 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01680 HME7025_01681 HME7025_01681 thrA thrA 1909591 1912053 - Aspartate kinase Amino-acid biosynthesis%3B ATP-binding%3B Chloroplast%3B Kinase%3B Methionine biosynthesis%3B Multifunctional enzyme%3B NADP%3B Nucleotide-binding%3B Oxidoreductase%3B Plastid%3B Repeat%3B Transferase%3B Transit peptide.%3B In the N-terminal sectio%3B belongs to the aspartokinase family%3B In the C-terminal sectio%3B belongs to the homoserine dehydrogenase family%3B Contains 2 ACT domains%3B KEGG: bacc:BRDCF_02130 bifunctional aspartokinase / homoserine dehydrogenase 1 gene gene-HME7025_01681 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01681 HME7025_01682 HME7025_01682 HME7025_01682 1912119 1912631 - UPF0702 transmembrane protein YrbG Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0702 family gene gene-HME7025_01682 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01682 HME7025_01683 HME7025_01683 HME7025_01683 1912633 1913034 - hypothetical protein gene gene-HME7025_01683 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01683 HME7025_01684 HME7025_01684 HME7025_01684 1913040 1913786 - Protein TolQ Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbB/TolQ family gene gene-HME7025_01684 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01684 HME7025_01685 HME7025_01685 HME7025_01685 1913857 1914804 - Exopolyphosphatase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Cobalt%3B Cytoplasm%3B Hydrolase%3B Lyase%3B Multifunctional enzyme%3B NAD%3B Zinc.%3B In the N-terminal sectio%3B belongs to the dehydroquinate synthase family%3B In the C-terminal sectio%3B belongs to the GppA/Ppx family%3B KEGG: oni:Osc7112_2121 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene-HME7025_01685 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01685 HME7025_01686 HME7025_01686 HME7025_01686 1914912 1916315 + Protein O-GlcNAc transferase Cell cycle%3B Cell division%3B Mitosis%3B Repeat%3B TPR repeat%3B Ubl conjugation pathway.%3B Component of the anaphase-promoting complex/cyclosome (APC/C)%2C a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and%2C in the presence of ubiquitin-conjugating E2 enzymes%2C it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates%3B Contains 8 TPR repeats%3B KEGG: psoj:PHYSODRAFT_553979 protein O-GlcNAc transferase gene gene-HME7025_01686 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01686 HME7025_01687 HME7025_01687 HME7025_01687 1916414 1919269 + putative zinc protease Hydrolase%3B Metal-binding%3B Metalloprotease%3B Protease%3B Zinc.%3B Belongs to the peptidase M16 family%3B KEGG: kko:Kkor_1537 zinc protease%3B Metalloendopeptidases gene gene-HME7025_01687 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01687 HME7025_01688 HME7025_01688 HME7025_01688 1919375 1919788 - UPF0403 protein Belongs to the UPF0403 family gene gene-HME7025_01688 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01688 HME7025_01689 HME7025_01689 HME7025_01689 1919823 1920161 - uncharacterized protein gene gene-HME7025_01689 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01689 HME7025_01690 HME7025_01690 HME7025_01690 1920165 1920590 - putative SufE-like protein Belongs to the SufE family gene gene-HME7025_01690 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01690 HME7025_01691 HME7025_01691 sufS sufS 1920592 1921812 - Cysteine desulfurase Cytoplasm%3B Lyase%3B Pyridoxal phosphate%3B Transferase.%3B Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine%2C an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon%2C which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro%2C that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily%3B KEGG: eco:b1680 cysteine desulfurase / selenocysteine lyase gene gene-HME7025_01691 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01691 HME7025_01692 HME7025_01692 HME7025_01692 1921817 1923091 - Protein ABCI7%2C chloroplastic Chloroplast%3B Plastid%3B Transit peptide. gene gene-HME7025_01692 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01692 HME7025_01693 HME7025_01693 HME7025_01693 1923098 1923847 - putative ATP-dependent transporter SufC ATP-binding%3B Cytoplasm%3B Nucleotide-binding%3B Transport.%3B Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation%3B Belongs to the ABC transporter superfamily. Ycf16 family%3B Contains 1 ABC transporter domain gene gene-HME7025_01693 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01693 HME7025_01694 HME7025_01694 HME7025_01694 1923993 1924319 + Protein HesB%2C vegetative Nitrogen fixation.%3B May be required for efficient nitrogen fixation. Belongs to the HesB/IscA family gene gene-HME7025_01694 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01694 HME7025_01695 HME7025_01695 HME7025_01695 1924327 1924938 - Maf-like protein Cytoplasm.%3B Belongs to the maf family gene gene-HME7025_01695 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01695 HME7025_01696 HME7025_01696 HME7025_01696 1925052 1925501 + hypothetical protein gene gene-HME7025_01696 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01696 HME7025_01697 HME7025_01697 HME7025_01697 1925578 1926153 + hypothetical protein gene gene-HME7025_01697 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01697 HME7025_01698 HME7025_01698 HME7025_01698 1926221 1926853 + Oxygen-insensitive NAD(P)H nitroreductase Flavoprotein%3B FMN%3B NAD%3B NADP%3B Oxidoreductase.%3B Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalent%3B two electrons are transferred. Capable of reducing nitrofurazone%2C quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2%2C4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species%3B Belongs to the nitroreductase family%3B KEGG: gfo:GFO_2187 null%3B Oxidoreductases gene gene-HME7025_01698 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01698 HME7025_01699 HME7025_01699 HME7025_01699 1926885 1928330 - Putative CCA tRNA nucleotidyltransferase ATP-binding%3B Cytoplasm%3B Mitochondrion%3B Nucleotide-binding%3B Nucleotidyltransferase%3B RNA-binding%3B Transferase.%3B This enzyme carries out synthesis of the tRNA CCA terminus without the direction of a template using the multiple accepting and donating subsites within its active site%3B Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family%3B KEGG: fjo:Fjoh_4906 tRNA nucleotidyltransferase (CCA-adding enzyme)%3B CCA tRNA nucleotidyltransferase gene gene-HME7025_01699 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01699 HME7025_01700 HME7025_01700 HME7025_01700 1928327 1928893 - L-threonylcarbamoyladenylate synthase ATP-binding%3B Cytoplasm%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B tRNA processing.%3B Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine%2C HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate%2C with the release of diphosphate%3B Belongs to the SUA5 family. TsaC subfamily%3B Contains 1 YrdC-like domain%3B KEGG: baco:OXB_1426 L-threonylcarbamoyladenylate synthase gene gene-HME7025_01700 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01700 HME7025_01701 HME7025_01701 rarS rarS 1929001 1930788 + Arginine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: pbt:ING2E5B_2192 arginyl-tRNA synthetase gene gene-HME7025_01701 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01701 HME7025_01702 HME7025_01702 HME7025_01702 1930835 1931416 + Glutathione peroxidase Oxidoreductase%3B Peroxidase.%3B Belongs to the glutathione peroxidase family%3B KEGG: samy:DB32_008853 glutathione peroxidase gene gene-HME7025_01702 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01702 HME7025_01703 HME7025_01703 menA menA 1931485 1932399 + 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase Cell inner membrane%3B Cell membrane%3B Membrane%3B Menaquinone biosynthesis%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Conversion of 1%2C4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Attaches octaprenylpyrophosphate%2C a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages: the removal of the carboxyl group of DHNA as CO(2)%2C the attachment of the isoprenoid side chain%2C and a quinol-to-quinone oxidation%2C which is thought to be spontaneous%3B Belongs to the MenA family. Type 1 subfamily%3B KEGG: lby:Lbys_1248 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase%3B 1%2C4-dihydroxy-2-naphthoate polyprenyltransferase gene gene-HME7025_01703 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01703 HME7025_01704 HME7025_01704 HME7025_01704 1932437 1933783 + Non-specific serine/threonine protein kinase Alternative splicing%3B Polymorphism%3B Repeat%3B TPR repeat.%3B Contains 13 TPR repeats%3B KEGG: cyb:CYB_1515 serine/threonine protein kinase%2C bacterial gene gene-HME7025_01704 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01704 HME7025_01705 HME7025_01705 HME7025_01705 1933786 1934559 - AMP nucleosidase Hydrolase.%3B Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations%3B Belongs to the AMP nucleosidase family%3B KEGG: sml:Smlt3963 AMP nucleosidase gene gene-HME7025_01705 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01705 HME7025_01706 HME7025_01706 HME7025_01706 1934626 1935087 + hypothetical protein gene gene-HME7025_01706 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01706 HME7025_01707 HME7025_01707 HME7025_01707 1935084 1936721 + Alkaline phosphatase Hydrolase%3B Metal-binding%3B Periplasm%3B Phosphoprotein%3B Signal%3B Zinc.%3B Alkaline phosphatase with broad substrate specificity. Has phosphatase activity towards nucleotide phosphates with a preference for ATP. Active towards a great variety of phosphomonoesters with the exception of 2'%2C3'-cyclic AMP and myo- inositol hexakisphosphate%3B KEGG: zmo:ZMO0938 alkaline phosphatase gene gene-HME7025_01707 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01707 HME7025_01708 HME7025_01708 ugdH ugdH 1936808 1938121 + UDP-glucose 6-dehydrogenase Cell wall biogenesis/degradation%3B Cytoplasm%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Stress response.%3B Catalyzes the conversion of UDP-glucose into UDP- glucuronate%2C one of the precursors of teichuronic acid. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family%3B KEGG: xfa:XF1606 UDPglucose 6-dehydrogenase gene gene-HME7025_01708 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01708 HME7025_01709 HME7025_01709 uxs1 uxs1 1938131 1939105 + UDP-glucuronate decarboxylase Acetylation%3B Alternative splicing%3B Decarboxylase%3B Golgi apparatus%3B Lyase%3B Membrane%3B NAD%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily%3B KEGG: rhd:R2APBS1_3701 UDP-glucuronate decarboxylase gene gene-HME7025_01709 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01709 HME7025_01710 HME7025_01710 HME7025_01710 1939341 1942649 - hypothetical protein gene gene-HME7025_01710 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01710 HME7025_01711 HME7025_01711 selD selD 1942914 1943951 + Selenide%2C water dikinase ATP-binding%3B Kinase%3B Magnesium%3B Nucleotide-binding%3B Selenium%3B Transferase.%3B Synthesizes selenophosphate from selenide and ATP%3B Belongs to the selenophosphate synthase 1 family. Class I subfamily%3B KEGG: pmu:PM0790 selenide%2C water dikinase gene gene-HME7025_01711 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01711 HME7025_01712 HME7025_01712 HME7025_01712 1943952 1944713 + Dihydrolipoyllysine-residue acetyltransferase Hydrolase%3B Serine esterase.%3B Displays esterase activity toward palmitoyl-CoA%2C malonyl-CoA and pNP-butyrate%3B Belongs to the DmpD/TodF/XylF esterase family%3B KEGG: azl:AZL_009060 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene-HME7025_01712 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01712 HME7025_01713 HME7025_01713 HME7025_01713 1944710 1945432 + 16S rRNA (cytidine(1402)-2'-O)-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmI family%3B KEGG: neu:NE1572 16S rRNA (cytidine1402-2'-O)-methyltransferase gene gene-HME7025_01713 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01713 HME7025_01714 HME7025_01714 HME7025_01714 1945456 1946097 + Hydroxyacylglutathione hydrolase Hydrolase%3B Metal-binding%3B Zinc.%3B Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid%3B Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family%3B KEGG: pmy:Pmen_2064 hydroxyacylglutathione hydrolase gene gene-HME7025_01714 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01714 HME7025_01715 HME7025_01715 cho1 cho1 1946099 1946821 + CDP-diacylglycerol--serine O-phosphatidyltransferase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the CDP-alcohol phosphatidyltransferase class-I family%3B KEGG: bco:Bcell_0861 CDP-diacylglycerol---serine O-phosphatidyltransferase gene gene-HME7025_01715 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01715 HME7025_01716 HME7025_01716 HME7025_01716 1946818 1947069 + Phosphoribosylformylglycinamidine synthase ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis.%3B Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Belongs to the PurS family%3B KEGG: scn:Solca_2260 phosphoribosylformylglycinamidine synthase gene gene-HME7025_01716 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01716 HME7025_01717 HME7025_01717 HME7025_01717 1947112 1947468 - hypothetical protein gene gene-HME7025_01717 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01717 HME7025_01718 HME7025_01718 HME7025_01718 1947816 1948385 + hypothetical protein gene gene-HME7025_01718 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01718 HME7025_01719 HME7025_01719 metF metF 1948421 1949374 - Methylenetetrahydrofolate reductase (NAD(P)H) Amino-acid biosynthesis%3B FAD%3B Flavoprotein%3B Methionine biosynthesis%3B NAD%3B NADP%3B Oxidoreductase.%3B Belongs to the methylenetetrahydrofolate reductase family%3B KEGG: rsi:Runsl_5412 methylenetetrahydrofolate reductase (NADPH) gene gene-HME7025_01719 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01719 HME7025_01720 HME7025_01720 metH metH 1949378 1953139 - Methionine synthase Amino-acid biosynthesis%3B Cobalamin%3B Cobalt%3B Metal-binding%3B Methionine biosynthesis%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Zinc.%3B Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine%2C yielding enzyme-bound cob(I)alamin and methionine. Subsequently%2C remethylates the cofactor using methyltetrahydrofolate (By similarity)%3B Belongs to the vitamin-B12 dependent methionine synthase family%3B Contains 1 Hcy-binding domain%3B Contains 1 pterin-binding domain%3B KEGG: ndo:DDD_1817 5-methyltetrahydrofolate--homocysteine methyltransferase gene gene-HME7025_01720 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01720 HME7025_01721 HME7025_01721 neuA neuA 1953239 1953991 - N-acylneuraminate cytidylyltransferase Cytoplasm%3B Lipopolysaccharide biosynthesis%3B Nucleotidyltransferase%3B Transferase.%3B Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria%3B Belongs to the KdsB family%3B KEGG: vha:VIBHAR_00677 N-acylneuraminate cytidylyltransferase gene gene-HME7025_01721 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01721 HME7025_01722 HME7025_01722 HME7025_01722 1954055 1954819 + hypothetical protein gene gene-HME7025_01722 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01722 HME7025_01723 HME7025_01723 HME7025_01723 1954809 1955753 + hypothetical protein gene gene-HME7025_01723 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01723 HME7025_01724 HME7025_01724 HME7025_01724 1955924 1956706 + hypothetical protein gene gene-HME7025_01724 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01724 HME7025_01725 HME7025_01725 HME7025_01725 1956697 1957653 + Aldose 1-epimerase KEGG: mro:MROS_0959 aldose 1-epimerase gene gene-HME7025_01725 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01725 HME7025_01726 HME7025_01726 HME7025_01726 1957680 1958570 + hypothetical protein gene gene-HME7025_01726 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01726 HME7025_01727 HME7025_01727 HME7025_01727 1958668 1959558 - Exopolyphosphatase Hydrolase.%3B Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response'%2C an adaptive process that allows bacteria to respond to amino acid starvation%2C resulting in the coordinated regulation of numerous cellular activities%3B Belongs to the GppA/Ppx family. GppA subfamily%3B KEGG: bth:BT_0540 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene-HME7025_01727 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01727 HME7025_01728 HME7025_01728 HME7025_01728 1959555 1959851 - hypothetical protein gene gene-HME7025_01728 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01728 HME7025_01729 HME7025_01729 HME7025_01729 1959991 1961556 + Chemotaxis protein CheY Chemotaxis%3B Cytoplasm%3B Magnesium%3B Metal-binding%3B Phosphoprotein%3B Two-component regulatory system.%3B Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY%2C which causes counterclockwise rotation of the flagella%2C resulting in smooth swimming%3B Contains 1 response regulatory domain gene gene-HME7025_01729 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01729 HME7025_01730 HME7025_01730 HME7025_01730 1961598 1962269 - Fe(3+)-transporting ATPase Amino-acid transport%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Methionine importer (TC 3. A. 1. 24) family%3B Contains 1 ABC transporter domain%3B KEGG: mvr:X781_10300 iron(III) transport system ATP-binding protein gene gene-HME7025_01730 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01730 HME7025_01731 HME7025_01731 talA talA 1962278 1962937 - Transaldolase Cytoplasm%3B Pentose shunt%3B Schiff base%3B Transferase.%3B Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway%3B Belongs to the transaldolase family. Type 3B subfamily%3B KEGG: spiu:SPICUR_04415 transaldolase gene gene-HME7025_01731 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01731 HME7025_01732 HME7025_01732 HME7025_01732 1963119 1963850 + Transmembrane and TPR repeat-containing protein Glycoprotein%3B Membrane%3B Repeat%3B TPR repeat%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the TMTC family%3B Contains 7 TPR repeats gene gene-HME7025_01732 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01732 HME7025_01733 HME7025_01733 HME7025_01733 1963869 1964228 + hypothetical protein gene gene-HME7025_01733 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01733 HME7025_01734 HME7025_01734 HME7025_01734 1964232 1965152 + hypothetical protein gene gene-HME7025_01734 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01734 HME7025_01735 HME7025_01735 HME7025_01735 1965273 1966010 - hypothetical protein gene gene-HME7025_01735 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01735 HME7025_01736 HME7025_01736 HME7025_01736 1966096 1967316 - Multidrug resistance protein Antibiotic resistance%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances%2C including such structurally diverse compounds as ethidium bromide%2C rhodamine and acridine dyes%2C tetraphenylphosphonium%2C puromycin%2C chloramphenicol%2C doxorubicin%2C and fluoroquinolone antibiotics. Belongs to the major facilitator superfamily. TCR/Tet family gene gene-HME7025_01736 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01736 HME7025_01737 HME7025_01737 iolE iolE 1967336 1968238 - Myo-inosose-2 dehydratase Cobalt%3B Lyase%3B Manganese.%3B Catalyzes the dehydration of inosose (2-keto-myo- inositol%2C 2KMI or 2%2C4%2C6/3%2C5-pentahydroxycyclohexanone) to 3D- (3%2C5/4)-trihydroxycyclohexane-1%2C2-dione (D-2%2C3-diketo-4-deoxy-epi- inositol)%3B Belongs to the IolE/MocC family%3B KEGG: sli:Slin_0439 inosose dehydratase gene gene-HME7025_01737 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01737 HME7025_01738 HME7025_01738 HME7025_01738 1968279 1969028 - Alkaline phosphatase KEGG: dfe:Dfer_1383 alkaline phosphatase gene gene-HME7025_01738 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01738 HME7025_01739 HME7025_01739 HME7025_01739 1969030 1972890 - Acetyl-CoA carboxylase ATP-binding%3B Biotin%3B Hydrolase%3B Ligase%3B Nucleotide-binding.%3B Involved in the utilization of lactams. Required for the conversion of exogenous 2-pyrrolidinone (gamma-butyrolactam) to endogenous gamma-amino-n-butyrate (GABA)%3B Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B Contains 1 biotinyl-binding domain%3B KEGG: vok:COSY_0959 acetyl-CoA carboxylase%2C biotin carboxylase subunit gene gene-HME7025_01739 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01739 HME7025_01740 HME7025_01740 pdxA pdxA 1973104 1974111 + 4-hydroxythreonine-4-phosphate dehydrogenase Cobalt%3B Cytoplasm%3B Magnesium%3B Metal-binding%3B NAD%3B NADP%3B Oxidoreductase%3B Pyridoxine biosynthesis%3B Zinc.%3B Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)%3B Belongs to the PdxA family%3B KEGG: pms:KNP414_05218 4-hydroxythreonine-4-phosphate dehydrogenase gene gene-HME7025_01740 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01740 HME7025_01741 HME7025_01741 HME7025_01741 1974113 1975039 + Phosphoglycerate dehydrogenase Cytoplasm%3B NAD%3B Oxidoreductase.%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily%3B KEGG: sht:KO02_19935 D-3-phosphoglycerate dehydrogenase gene gene-HME7025_01741 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01741 HME7025_01742 HME7025_01742 HME7025_01742 1975036 1977477 + Endonuclease MutS2 ATP-binding%3B DNA-binding%3B Endonuclease%3B Hydrolase%3B Nuclease%3B Nucleotide-binding.%3B Belongs to the DNA mismatch repair MutS family. MutS2 subfamily%3B Contains 1 Smr domain gene gene-HME7025_01742 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01742 HME7025_01743 HME7025_01743 HME7025_01743 1977562 1977990 + Peptidylprolyl isomerase Isomerase%3B Nucleus%3B Rotamase.%3B PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)%3B Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily%3B Contains 1 PPIase FKBP-type domain%3B KEGG: rsi:Runsl_4156 peptidylprolyl isomerase gene gene-HME7025_01743 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01743 HME7025_01744 HME7025_01744 HME7025_01744 1977999 1980434 + hypothetical protein gene gene-HME7025_01744 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01744 HME7025_01745 HME7025_01745 HME7025_01745 1980439 1981329 + UPF0701 protein YloC Belongs to the UPF0701 family gene gene-HME7025_01745 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01745 HME7025_01746 HME7025_01746 HME7025_01746 1981403 1981792 - hypothetical protein gene gene-HME7025_01746 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01746 HME7025_01747 HME7025_01747 HME7025_01747 1981803 1982669 - uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Contains 1 EamA domain gene gene-HME7025_01747 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01747 HME7025_01748 HME7025_01748 hemH hemH 1982674 1983684 - Protoporphyrin ferrochelatase Cytoplasm%3B Heme biosynthesis%3B Iron%3B Lyase%3B Metal-binding%3B Porphyrin biosynthesis.%3B Catalyzes the ferrous insertion into protoporphyrin IX%3B Belongs to the ferrochelatase family%3B KEGG: saz:Sama_1316 ferrochelatase gene gene-HME7025_01748 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01748 HME7025_01749 HME7025_01749 HME7025_01749 1983721 1984875 - hypothetical protein gene gene-HME7025_01749 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01749 HME7025_01750 HME7025_01750 HME7025_01750 1984878 1987289 - hypothetical protein gene gene-HME7025_01750 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01750 HME7025_01751 HME7025_01751 HME7025_01751 1987351 1988439 - NADH:ubiquinone reductase (H(+)-translocating) Membrane%3B NAD%3B NADP%3B Oxidoreductase%3B Plastoquinone%3B Quinone%3B Thylakoid%3B Transmembrane%3B Transmembrane helix.%3B NDH-1 shuttles electrons from an unknown electron donor%2C via FMN and iron-sulfur (Fe-S) centers%2C to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 1 family%3B KEGG: fae:FAES_4633 NADH-quinone oxidoreductase subunit H gene gene-HME7025_01751 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01751 HME7025_01752 HME7025_01752 metZ metZ 1988443 1989606 - O-acetylhomoserine (thiol)-lyase Amino-acid biosynthesis%3B Cysteine biosynthesis%3B Pyridoxal phosphate%3B Transferase.%3B Transforms O-acetylhomoserine into homocysteine. Belongs to the trans-sulfuration enzymes family%3B KEGG: rfr:Rfer_2682 O-succinylhomoserine sulfhydrylase%3B Transferring alkyl or aryl groups%2C other than methyl groups gene gene-HME7025_01752 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01752 HME7025_01753 HME7025_01753 HME7025_01753 1989810 1991171 + hypothetical protein gene gene-HME7025_01753 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01753 HME7025_01754 HME7025_01754 HME7025_01754 1991201 1992535 + Inositol 2-dehydrogenase NADP%3B Oxidoreductase.%3B Catalyzes the NADPH-specific reduction of 1%2C5-anhydro-D- fructose to 1%2C5-anhydro-D-mannitol. Also shows some activity against structurally related compounds such as 3-keto-1%2C5-anhydro- D-fructose%2C D-glucosone and D-xylosone. The enzyme cannot use NADH as cosubstrate. Belongs to the Gfo/Idh/MocA family%3B KEGG: ang:ANI_1_676144 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_01754 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01754 HME7025_01755 HME7025_01755 HME7025_01755 1992568 1993449 + D-alanine--D-alanine ligase KEGG: hhy:Halhy_2387 D-alanine-D-alanine ligase gene gene-HME7025_01755 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01755 HME7025_01756 HME7025_01756 HME7025_01756 1993454 1993756 + Thiosulfate sulfurtransferase PspE Periplasm%3B Signal%3B Stress response%3B Transferase.%3B The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur-transfer reaction from thiosulfate to cyanide%2C to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity. Contains 1 rhodanese domain gene gene-HME7025_01756 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01756 HME7025_01757 HME7025_01757 HME7025_01757 1993758 1994039 + hypothetical protein gene gene-HME7025_01757 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01757 HME7025_01758 HME7025_01758 HME7025_01758 1994793 1996061 + hypothetical protein gene gene-HME7025_01758 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01758 HME7025_01759 HME7025_01759 HME7025_01759 1996075 1997838 + hypothetical protein gene gene-HME7025_01759 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01759 HME7025_01760 HME7025_01760 HME7025_01760 1997838 1999259 + hypothetical protein gene gene-HME7025_01760 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01760 HME7025_01761 HME7025_01761 HME7025_01761 1999264 1999902 + uncharacterized protein Contains 1 Fe2OG dioxygenase domain%3B With 2-oxoglutarate as one donor%2C and incorporation of one atom each of oxygen into both donors gene gene-HME7025_01761 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01761 HME7025_01762 HME7025_01762 HME7025_01762 2000150 2000545 + hypothetical protein gene gene-HME7025_01762 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01762 HME7025_01763 HME7025_01763 HME7025_01763 2000567 2000890 + hypothetical protein gene gene-HME7025_01763 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01763 HME7025_01764 HME7025_01764 HME7025_01764 2001163 2001516 + hypothetical protein gene gene-HME7025_01764 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01764 HME7025_01765 HME7025_01765 HME7025_01765 2001513 2001824 + hypothetical protein gene gene-HME7025_01765 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01765 HME7025_01766 HME7025_01766 HME7025_01766 2001833 2002633 + Methionyl aminopeptidase Aminopeptidase%3B Cytoplasm%3B Hydrolase%3B Metal-binding%3B Protease.%3B Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-%2C Cys%2C Gly%2C Pro%2C Ser%2C Thr%2C or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed%3B Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily%3B KEGG: yli:YALI0D17138g methionyl aminopeptidase gene gene-HME7025_01766 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01766 HME7025_01767 HME7025_01767 HME7025_01767 2004176 2004976 - hypothetical protein gene gene-HME7025_01767 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01767 HME7025_01768 HME7025_01768 HME7025_01768 2005000 2005425 - hypothetical protein gene gene-HME7025_01768 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01768 HME7025_01769 HME7025_01769 HME7025_01769 2005522 2006430 - tRNA dimethylallyltransferase ATP-binding%3B Magnesium%3B Nucleotide-binding%3B Transferase%3B tRNA processing.%3B Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine%2C leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)%3B Belongs to the IPP transferase family%3B KEGG: bapf:BUMPF009_CDS00036 tRNA dimethylallyltransferase gene gene-HME7025_01769 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01769 HME7025_01770 HME7025_01770 HME7025_01770 2006427 2007086 - hypothetical protein gene gene-HME7025_01770 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01770 HME7025_01771 HME7025_01771 HME7025_01771 2007096 2008769 - Low affinity sodium-glucose cotransporter Glycoprotein%3B Ion transport%3B Membrane%3B Sodium%3B Sodium transport%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Sodium-dependent glucose transporter%3B Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene-HME7025_01771 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01771 HME7025_01772 HME7025_01772 HME7025_01772 2008867 2010423 - uncharacterized protein Coiled coil.%3B Belongs to the NEMF family gene gene-HME7025_01772 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01772 HME7025_01773 HME7025_01773 HME7025_01773 2010450 2011040 + Thymidylate synthase Belongs to the IMPACT family%3B KEGG: psp:PSPPH_4623 thymidylate synthase gene gene-HME7025_01773 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01773 HME7025_01774 HME7025_01774 kdxD kdxD 2011059 2011898 + 2-dehydro-3-deoxy-D-arabinonate dehydratase Calcium%3B Carbohydrate metabolism%3B Lyase%3B Magnesium%3B Metal-binding.%3B Participates in a pentose oxidation pathway that converts D-arabinonate to 2-oxoglutarate%3B Belongs to the FAH family%3B KEGG: psl:Psta_0399 2-dehydro-3-deoxy-D-arabinonate dehydratase gene gene-HME7025_01774 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01774 HME7025_01775 HME7025_01775 aldH aldH 2011898 2013388 + Aldehyde dehydrogenase (NADP(+)) NADP%3B Oxidoreductase.%3B Catalyzes the NAD(P)(+)-dependent oxidation of alpha- ketoglutaric semialdehyde (alphaKGSA) to alpha-ketoglutarate in the D-glutarate degradation pathway%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: cps:CPS_1451 NADP-dependent aldehyde dehydrogenase gene gene-HME7025_01775 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01775 HME7025_01776 HME7025_01776 yoeB yoeB 2013483 2013743 - Toxin YoeB Endonuclease%3B Hydrolase%3B Nuclease%3B Repressor%3B RNA-binding%3B Toxin%3B Transcription%3B Transcription regulation.%3B Toxic component of a toxin-antitoxin (TA) module. It has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. Has an in vitro RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription%2C YeoB acts as a corepressor (By similarity)%3B Belongs to the YoeB family%3B KEGG: scn:Solca_2031 toxin YoeB%3B Acting on ester bonds gene gene-HME7025_01776 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01776 HME7025_01777 HME7025_01777 HME7025_01777 2013740 2014135 - hypothetical protein gene gene-HME7025_01777 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01777 HME7025_01778 HME7025_01778 HME7025_01778 2014209 2016845 - Chaperone protein ClpB ATP-binding%3B Chaperone%3B Coiled coil%3B Cytoplasm%3B Nucleotide-binding%3B Repeat%3B Stress response.%3B Part of a stress-induced multi-chaperone system%2C it is involved in the recovery of the cell from heat-induced damage%2C in cooperation with DnaK%2C DnaJ and GrpE. Acts before DnaK%2C in the processing of protein aggregates. Protein binding stimulates the ATPase activit%3B ATP hydrolysis unfolds the denatured protein aggregates%2C which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates%2C contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Necessary for survival of C. glutamicum at high temperatures%3B Belongs to the ClpA/ClpB family gene gene-HME7025_01778 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01778 HME7025_01779 HME7025_01779 HME7025_01779 2016929 2020228 - Histidine protein kinase DivJ ATP-binding%3B Cell cycle%3B Cell division%3B Cell membrane%3B Differentiation%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system.%3B Kinase required for the regulation of cell division and differentiation. Is part of a signal transduction pathway%2C activating PleD by phosphorylation. Contains 1 histidine kinase domain%3B KEGG: chu:CHU_2784 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene-HME7025_01779 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01779 HME7025_01780 HME7025_01780 ksgA ksgA 2020255 2021085 + 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase Cytoplasm%3B Methyltransferase%3B RNA-binding%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase.%3B Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily%3B KEGG: phe:Phep_3812 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase gene gene-HME7025_01780 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01780 HME7025_01781 HME7025_01781 HME7025_01781 2021146 2022522 + Magnesium transporter MgtE CBS domain%3B Cell membrane%3B Magnesium%3B Membrane%3B Metal-binding%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Acts as a magnesium transporter%3B Belongs to the SLC41A transporter family%3B Contains 2 CBS domains gene gene-HME7025_01781 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01781 HME7025_01782 HME7025_01782 dtd1 dtd1 2022524 2022979 + D-tyrosyl-tRNA(Tyr) deacylase Cytoplasm%3B DNA replication%3B DNA-binding%3B Hydrolase%3B Metal-binding%3B Nucleus%3B Phosphoprotein.%3B ATPase involved in DNA replication%2C may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr)%2C a possible defense mechanism against a harmful effect of D-tyrosine (By similarity)%3B Belongs to the DTD family%3B KEGG: eco:b3887 D-tyrosyl-tRNA(Tyr) deacylase%3B Acting on ester bonds gene gene-HME7025_01782 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01782 HME7025_01783 HME7025_01783 HME7025_01783 2022976 2023305 + 3-phosphoshikimate 1-carboxyvinyltransferase KEGG: eao:BD94_0226 3-phosphoshikimate 1-carboxyvinyltransferase gene gene-HME7025_01783 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01783 HME7025_01784 HME7025_01784 hprA hprA 2023302 2024246 + Glycerate dehydrogenase Cytoplasm%3B NAD%3B NADP%3B Oxidoreductase.%3B Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle%2C and may also play an important role in C2 reactions%2C by interconverting glyoxylate and glycolate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: kin:AB182_20230 glycerate dehydrogenase gene gene-HME7025_01784 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01784 HME7025_01785 HME7025_01785 HME7025_01785 2024243 2024932 - hypothetical protein gene gene-HME7025_01785 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01785 HME7025_01786 HME7025_01786 HME7025_01786 2025021 2026325 - Gluconate permease Cell inner membrane%3B Cell membrane%3B Gluconate utilization%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the GntP permease family gene gene-HME7025_01786 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01786 HME7025_01787 HME7025_01787 HME7025_01787 2026329 2027306 - hypothetical protein gene gene-HME7025_01787 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01787 HME7025_01788 HME7025_01788 HME7025_01788 2027480 2029183 + hypothetical protein gene gene-HME7025_01788 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01788 HME7025_01789 HME7025_01789 HME7025_01789 2029486 2030670 - hypothetical protein gene gene-HME7025_01789 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01789 HME7025_01790 HME7025_01790 HME7025_01790 2030819 2033977 - hypothetical protein gene gene-HME7025_01790 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01790 HME7025_01791 HME7025_01791 HME7025_01791 2034081 2035532 - hypothetical protein gene gene-HME7025_01791 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01791 HME7025_01792 HME7025_01792 HME7025_01792 2035668 2036987 - hypothetical protein gene gene-HME7025_01792 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01792 HME7025_01793 HME7025_01793 HME7025_01793 2037017 2037361 - hypothetical protein gene gene-HME7025_01793 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01793 HME7025_01794 HME7025_01794 HME7025_01794 2037471 2038814 + Inositol 2-dehydrogenase NAD%3B Oxidoreductase.%3B Catalyzes the NAD(+)-dependent oxidation of scyllo- inositol to 2%2C4%2C6/3%2C5-pentahydroxycyclohexanone (scyllo-inosose)%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: kva:Kvar_3231 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_01794 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01794 HME7025_01795 HME7025_01795 HME7025_01795 2038819 2039940 + Heparan-alpha-glucosaminide N-acetyltransferase Acyltransferase%3B Alternative initiation%3B Disease mutation%3B Disulfide bond%3B Glycoprotein%3B Lysosome%3B Membrane%3B Mucopolysaccharidosis%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate%2C converting it into a substrate for luminal alpha-N-acetyl glucosaminidase%3B KEGG: hsa:138050 heparan-alpha-glucosaminide N-acetyltransferase gene gene-HME7025_01795 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01795 HME7025_01796 HME7025_01796 nagB nagB 2039952 2040716 + Glucosamine-6-phosphate deaminase Carbohydrate metabolism%3B Hydrolase.%3B Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion%3B Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily%3B KEGG: shg:Sph21_0371 glucosamine-6-phosphate deaminase gene gene-HME7025_01796 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01796 HME7025_01797 HME7025_01797 HME7025_01797 2040716 2041909 + N-acetylglucosamine-6-phosphate deacetylase Carbohydrate metabolism%3B Hydrolase%3B Metal-binding.%3B Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: nso:NIASO_12625 N-acetylglucosamine-6-phosphate deacetylase gene gene-HME7025_01797 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01797 HME7025_01798 HME7025_01798 HME7025_01798 2041904 2042620 - hypothetical protein gene gene-HME7025_01798 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01798 HME7025_01799 HME7025_01799 HME7025_01799 2042636 2043661 - hypothetical protein gene gene-HME7025_01799 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01799 HME7025_01800 HME7025_01800 HME7025_01800 2043682 2044986 - Glucose/galactose transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Intake of glucose and galactose%3B Belongs to the major facilitator superfamily. FHS transporter (TC 2. A. 1. 7) family gene gene-HME7025_01800 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01800 HME7025_01801 HME7025_01801 HME7025_01801 2045437 2048004 + Pesticin receptor Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Receptor for the bacteriocin pesticin and for the siderophore yersiniabactin%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_01801 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01801 HME7025_01802 HME7025_01802 HME7025_01802 2048079 2049233 - hypothetical protein gene gene-HME7025_01802 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01802 HME7025_01803 HME7025_01803 HME7025_01803 2049236 2051608 - Vitamin B12 transporter BtuB Calcium%3B Cell outer membrane%3B Ion transport%3B Membrane%3B Metal-binding%3B Porin%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB%3B Belongs to the TonB-dependent receptor family. BtuB (TC 1. B. 14. 3. 1) subfamily gene gene-HME7025_01803 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01803 HME7025_01804 HME7025_01804 HME7025_01804 2051672 2052049 - hypothetical protein gene gene-HME7025_01804 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01804 HME7025_01805 HME7025_01805 HME7025_01805 2052098 2053321 - hypothetical protein gene gene-HME7025_01805 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01805 HME7025_01806 HME7025_01806 HME7025_01806 2053331 2053930 - CRP-like cAMP-activated global transcriptional regulator Activator%3B cAMP%3B cAMP-binding%3B DNA-binding%3B Nucleotide-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Virulence.%3B Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites%2C causing DNA- bending%2C to regulate transcription. cAMP improves binding to specific DNA sequences%2C probably by altering protein conformation. Activates expression of whiB1%3B Contains 1 cyclic nucleotide-binding domain%3B Contains 1 HTH crp-type DNA-binding domain gene gene-HME7025_01806 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01806 HME7025_01807 HME7025_01807 nirK nirK 2054067 2054651 + Nitrite reductase (NO-forming) KEGG: bps:BPSS1452 nitrite reductase (NO-forming) gene gene-HME7025_01807 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01807 HME7025_01808 HME7025_01808 nosZ nosZ 2054675 2056654 + Nitrous-oxide reductase Calcium%3B Copper%3B Metal-binding%3B Oxidoreductase%3B Periplasm%3B Plasmid%3B Signal.%3B Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide. Belongs to the NosZ family%3B In the C-terminal sectio%3B belongs to the cytochrome c oxidase subunit 2 family%3B KEGG: fco:FCOL_10605 nitrous-oxide reductase gene gene-HME7025_01808 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01808 HME7025_01809 HME7025_01809 HME7025_01809 2056670 2057275 + uncharacterized protein Signal.%3B Contains 1 FAS1 domain gene gene-HME7025_01809 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01809 HME7025_01810 HME7025_01810 HME7025_01810 2057291 2058289 + hypothetical protein gene gene-HME7025_01810 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01810 HME7025_01811 HME7025_01811 HME7025_01811 2058286 2059533 + hypothetical protein gene gene-HME7025_01811 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01811 HME7025_01812 HME7025_01812 HME7025_01812 2059530 2060228 + Spermidine/putrescine import ATP-binding protein PotA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene-HME7025_01812 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01812 HME7025_01813 HME7025_01813 HME7025_01813 2060235 2061002 + hypothetical protein gene gene-HME7025_01813 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01813 HME7025_01814 HME7025_01814 HME7025_01814 2061005 2061439 + hypothetical protein gene gene-HME7025_01814 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01814 HME7025_01815 HME7025_01815 HME7025_01815 2061599 2061790 + hypothetical protein gene gene-HME7025_01815 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01815 HME7025_01816 HME7025_01816 HME7025_01816 2061817 2065032 - Blue-light-activated protein ATP-binding%3B Chromophore%3B Flavoprotein%3B FMN%3B Kinase%3B Nucleotide-binding%3B Phosphoprotein%3B Photoreceptor protein%3B Receptor%3B Sensory transduction%3B Transferase%3B Virulence.%3B Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light%3B Contains 1 histidine kinase domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 1 response regulatory domain gene gene-HME7025_01816 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01816 HME7025_01817 HME7025_01817 HME7025_01817 2065166 2065714 - hypothetical protein gene gene-HME7025_01817 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01817 HME7025_01818 HME7025_01818 HME7025_01818 2065785 2065889 - hypothetical protein gene gene-HME7025_01818 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01818 HME7025_01819 HME7025_01819 HME7025_01819 2066261 2066818 - hypothetical protein gene gene-HME7025_01819 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01819 HME7025_01820 HME7025_01820 HME7025_01820 2066951 2068126 - hypothetical protein gene gene-HME7025_01820 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01820 HME7025_01821 HME7025_01821 HME7025_01821 2068744 2071641 + Nitrogen fixation regulatory protein ATP-binding%3B FAD%3B Flavoprotein%3B Kinase%3B Nitrogen fixation%3B Nucleotide-binding%3B Phosphoprotein%3B Repeat%3B Transcription%3B Transcription regulation%3B Transferase%3B Two-component regulatory system.%3B Required for the inhibition of NifA activity in response to oxygen and low level of fixed nitrogen. Contains 1 histidine kinase domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 2 PAS (PER-ARNT-SIM) domains%3B KEGG: ava:Ava_3004 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene-HME7025_01821 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01821 HME7025_01822 HME7025_01822 HME7025_01822 2071990 2072063 - tRNA-Arg tRNA gene-HME7025_01822 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01822 HME7025_01823 HME7025_01823 paaG paaG 2072150 2072929 - 2-(1%2C2-epoxy-1%2C2-dihydrophenyl)acetyl-CoA isomerase Fatty acid metabolism%3B Lipid metabolism%3B Lyase.%3B Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA%2C and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crotonyl-CoA. Inactive towards (R)-3-hydroxybutyryl-CoA%3B Belongs to the enoyl-CoA hydratase/isomerase family%3B KEGG: rpm:RSPPHO_02292 2-(1%2C2-epoxy-1%2C2-dihydrophenyl)acetyl-CoA isomerase gene gene-HME7025_01823 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01823 HME7025_01824 HME7025_01824 HME7025_01824 2073007 2073372 - hypothetical protein gene gene-HME7025_01824 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01824 HME7025_01825 HME7025_01825 HME7025_01825 2073514 2074953 - RNA polymerase sigma-54 factor Arginine metabolism%3B DNA-binding%3B DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Sigma factor%3B Transcription%3B Transcription regulation%3B Transferase.%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC). Belongs to the sigma-54 factor family gene gene-HME7025_01825 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01825 HME7025_01826 HME7025_01826 narS narS 2075104 2076534 + Asparagine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: eol:Emtol_1342 asparaginyl-tRNA synthetase gene gene-HME7025_01826 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01826 HME7025_01827 HME7025_01827 HME7025_01827 2076536 2076913 + Undecaprenol kinase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Kinase%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Nucleotide-binding%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Recycling of diacylglycerol produced during the turnover of membrane phospholipid%3B Belongs to the bacterial diacylglycerol kinase family%3B KEGG: bli:BL03672 undecaprenol kinase gene gene-HME7025_01827 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01827 HME7025_01828 HME7025_01828 HME7025_01828 2076929 2077585 + hypothetical protein gene gene-HME7025_01828 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01828 HME7025_01829 HME7025_01829 murA murA 2077595 2078902 + UDP-N-acetylglucosamine 1-carboxyvinyltransferase Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Peptidoglycan synthesis%3B Pyruvate%3B Transferase.%3B Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine%3B Belongs to the EPSP synthase family. MurA subfamily%3B KEGG: dfe:Dfer_4252 UDP-N-acetylglucosamine 1-carboxyvinyltransferase gene gene-HME7025_01829 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01829 HME7025_01830 HME7025_01830 HME7025_01830 2078906 2080276 + putative multidrug resistance protein NorM Antiport%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Multidrug efflux pump%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene-HME7025_01830 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01830 HME7025_01831 HME7025_01831 neu1 neu1 2080433 2081593 - Exo-alpha-sialidase Cell wall%3B Glycosidase%3B Hydrolase%3B Peptidoglycan-anchor%3B Repeat%3B Secreted%3B Signal.%3B Belongs to the glycosyl hydrolase 33 family%3B Contains 4 BNR repeats%3B KEGG: hhy:Halhy_6270 sialidase-1 gene gene-HME7025_01831 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01831 HME7025_01832 HME7025_01832 HME7025_01832 2081817 2082170 + Large-conductance mechanosensitive channel Cell inner membrane%3B Cell membrane%3B Ion channel%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell%3B Belongs to the MscL family gene gene-HME7025_01832 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01832 HME7025_01833 HME7025_01833 sthA sthA 2082172 2083578 - NAD(P)(+) transhydrogenase (Si-specific) Cytoplasm%3B Disulfide bond%3B FAD%3B Flavoprotein%3B Glycolysis%3B NAD%3B Oxidoreductase%3B Redox-active center.%3B Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: pae:PA2991 NAD(P) transhydrogenase gene gene-HME7025_01833 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01833 HME7025_01834 HME7025_01834 HME7025_01834 2083626 2085191 - Dihydrolipoyllysine-residue succinyltransferase Acyltransferase%3B Lipoyl%3B Transferase%3B Tricarboxylic acid cycle.%3B The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: hin:HI1661 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) gene gene-HME7025_01834 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01834 HME7025_01835 HME7025_01835 ogdH ogdH 2085214 2087943 - Oxoglutarate dehydrogenase (succinyl-transferring) Glycolysis%3B Oxidoreductase%3B Thiamine pyrophosphate.%3B The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the alpha-ketoglutarate dehydrogenase family%3B KEGG: bbd:Belba_1340 2-oxoglutarate dehydrogenase E1 component gene gene-HME7025_01835 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01835 HME7025_01836 HME7025_01836 HME7025_01836 2088190 2089125 - hypothetical protein gene gene-HME7025_01836 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01836 HME7025_01837 HME7025_01837 HME7025_01837 2089135 2090079 - hypothetical protein gene gene-HME7025_01837 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01837 HME7025_01838 HME7025_01838 HME7025_01838 2090165 2091991 + Chaperone protein htpG ATP-binding%3B Chaperone%3B Cytoplasm%3B Nucleotide-binding%3B Stress response.%3B Molecular chaperone. Has ATPase activity%3B Belongs to the heat shock protein 90 family gene gene-HME7025_01838 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01838 HME7025_01839 HME7025_01839 HME7025_01839 2092066 2092671 - hypothetical protein gene gene-HME7025_01839 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01839 HME7025_01840 HME7025_01840 HME7025_01840 2092769 2094313 - hypothetical protein gene gene-HME7025_01840 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01840 HME7025_01841 HME7025_01841 tilS tilS 2094366 2095700 + tRNA(Ile)-lysidine synthetase ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B tRNA processing.%3B Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU%2C in an ATP-dependent manner. Cytidine is converted to lysidine%2C thus changing the amino acid specificity of the tRNA from methionine to isoleucine%3B Belongs to the tRNA(Ile)-lysidine synthase family%3B KEGG: cmr:Cycma_2392 tRNA(Ile)-lysidine synthase gene gene-HME7025_01841 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01841 HME7025_01842 HME7025_01842 HME7025_01842 2095808 2096584 - Chloride peroxidase Acetoin catabolism%3B Acyltransferase%3B Lipoyl%3B Transferase.%3B Contains 1 lipoyl-binding domain%3B KEGG: ppuu:PputUW4_03310 non-heme chloroperoxidase gene gene-HME7025_01842 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01842 HME7025_01843 HME7025_01843 HME7025_01843 2096656 2097627 - hypothetical protein gene gene-HME7025_01843 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01843 HME7025_01844 HME7025_01844 HME7025_01844 2097617 2097949 - Transcriptional repressor SdpR Cytoplasm%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation.%3B Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation%3B Contains 1 HTH arsR-type DNA-binding domain gene gene-HME7025_01844 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01844 HME7025_01845 HME7025_01845 HME7025_01845 2098284 2098538 - hypothetical protein gene gene-HME7025_01845 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01845 HME7025_01846 HME7025_01846 thiE thiE 2098542 2099168 - Thiamine phosphate synthase Magnesium%3B Metal-binding%3B Thiamine biosynthesis%3B Transferase.%3B Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)%3B Belongs to the thiamine-phosphate synthase family%3B KEGG: rsi:Runsl_3247 thiamine-phosphate pyrophosphorylase gene gene-HME7025_01846 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01846 HME7025_01847 HME7025_01847 HME7025_01847 2099165 2100220 - Putative hydrogenase expression/formation protein Belongs to the HypE family gene gene-HME7025_01847 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01847 HME7025_01848 HME7025_01848 HME7025_01848 2100220 2100942 - hypothetical protein gene gene-HME7025_01848 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01848 HME7025_01849 HME7025_01849 HME7025_01849 2101251 2102159 - hypothetical protein gene gene-HME7025_01849 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01849 HME7025_01850 HME7025_01850 HME7025_01850 2102184 2102510 - hypothetical protein gene gene-HME7025_01850 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01850 HME7025_01851 HME7025_01851 HME7025_01851 2102558 2103448 - hypothetical protein gene gene-HME7025_01851 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01851 HME7025_01852 HME7025_01852 HME7025_01852 2103488 2105131 - Lipid A export ATP-binding/permease protein MsbA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Lipid transport%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily. Lipid exporter (TC 3. A. 1. 106) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene-HME7025_01852 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01852 HME7025_01853 HME7025_01853 HME7025_01853 2105249 2105401 - hypothetical protein gene gene-HME7025_01853 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01853 HME7025_01854 HME7025_01854 impA impA 2105409 2106209 - Inositol-phosphate phosphatase Hydrolase%3B Magnesium%3B Metal-binding.%3B Belongs to the inositol monophosphatase family%3B KEGG: bbd:Belba_1181 myo-inositol-1(or 4)-monophosphatase gene gene-HME7025_01854 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01854 HME7025_01855 HME7025_01855 ctpA ctpA 2106209 2108338 - C-terminal processing peptidase Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Protease%3B Serine protease%3B Signal.%3B Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses (By similarity)%3B Belongs to the peptidase S41A family%3B Contains 1 PDZ (DHR) domain%3B KEGG: srd:SD10_03380 carboxyl-terminal processing protease gene gene-HME7025_01855 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01855 HME7025_01856 HME7025_01856 HME7025_01856 2108357 2109133 - Peptidylprolyl isomerase Isomerase%3B Rotamase%3B Secreted%3B Signal%3B Virulence.%3B May be an essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: psd:DSC_10905 peptidylprolyl isomerase gene gene-HME7025_01856 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01856 HME7025_01857 HME7025_01857 atpA atpA 2109374 2110954 + H(+)-transporting two-sector ATPase ATP synthesis%3B ATP-binding%3B CF(1)%3B Hydrogen ion transport%3B Hydrolase%3B Ion transport%3B Membrane%3B Nucleotide-binding%3B Thylakoid%3B Transport.%3B Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: sat:SYN_00546 F-type H+-transporting ATPase subunit alpha gene gene-HME7025_01857 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01857 HME7025_01858 HME7025_01858 HME7025_01858 2110969 2111850 + ATP synthase gamma chain ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(1)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transport.%3B Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex%3B Belongs to the ATPase gamma chain family gene gene-HME7025_01858 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01858 HME7025_01859 HME7025_01859 HME7025_01859 2111855 2112679 + hypothetical protein gene gene-HME7025_01859 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01859 HME7025_01860 HME7025_01860 HME7025_01860 2112740 2114011 + GTPase HflX Cytoplasm%3B GTP-binding%3B Magnesium%3B Metal-binding%3B Nucleotide-binding.%3B GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family%3B Contains 1 Hflx-type G (guanine nucleotide-binding) domain gene gene-HME7025_01860 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01860 HME7025_01861 HME7025_01861 HME7025_01861 2114081 2114932 - hypothetical protein gene gene-HME7025_01861 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01861 HME7025_01862 HME7025_01862 HME7025_01862 2115047 2116084 - hypothetical protein gene gene-HME7025_01862 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01862 HME7025_01863 HME7025_01863 copB copB 2116342 2118714 - Cu(2+)-exporting ATPase ATP-binding%3B Cell membrane%3B Copper%3B Copper transport%3B Hydrolase%3B Ion transport%3B Magnesium%3B Membrane%3B Metal-binding%3B Nucleotide-binding%3B Phosphoprotein%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Involved in copper efflux. Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B KEGG: fjo:Fjoh_3074 Cu2+-exporting ATPase gene gene-HME7025_01863 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01863 HME7025_01864 HME7025_01864 HME7025_01864 2119762 2119836 - tRNA-Arg tRNA gene-HME7025_01864 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01864 HME7025_01865 HME7025_01865 HME7025_01865 2119966 2121576 + hypothetical protein gene gene-HME7025_01865 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01865 HME7025_01866 HME7025_01866 HME7025_01866 2121684 2122523 + hypothetical protein gene gene-HME7025_01866 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01866 HME7025_01867 HME7025_01867 HME7025_01867 2122717 2126871 - Alpha-agarase Calcium%3B Carbohydrate metabolism%3B Glycosidase%3B Hydrolase%3B Metal-binding%3B Polysaccharide degradation%3B Signal.%3B Alpha-agarase. Hydrolyzes agarose%2C agarohexaose%2C neoagarohexaose and porphyran. Hydrolysis of porphyran by this enzyme improves its antioxidant activity. Does not hydrolyze kappa-carrageenan%2C iota-carrageenen or lambda-carrageenan%3B Belongs to the glycosyl hydrolase 96 family%3B Contains 1 CBM6 (carbohydrate binding type-6) domain gene gene-HME7025_01867 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01867 HME7025_01868 HME7025_01868 HME7025_01868 2127113 2131099 - Alpha-agarase Calcium%3B Carbohydrate metabolism%3B Glycosidase%3B Hydrolase%3B Metal-binding%3B Polysaccharide degradation%3B Signal.%3B Alpha-agarase. Hydrolyzes agarose%2C agarohexaose%2C neoagarohexaose and porphyran. Hydrolysis of porphyran by this enzyme improves its antioxidant activity. Does not hydrolyze kappa-carrageenan%2C iota-carrageenen or lambda-carrageenan%3B Belongs to the glycosyl hydrolase 96 family%3B Contains 1 CBM6 (carbohydrate binding type-6) domain gene gene-HME7025_01868 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01868 HME7025_01869 HME7025_01869 HME7025_01869 2131383 2189852 - Mucin-22 Membrane%3B Polymorphism%3B Repeat%3B Signal%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_01869 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01869 HME7025_01870 HME7025_01870 HME7025_01870 2190031 2191236 - hypothetical protein gene gene-HME7025_01870 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01870 HME7025_01871 HME7025_01871 oxcT oxcT 2191801 2193177 - 3-oxoacid CoA-transferase Mitochondrion%3B Polymorphism%3B Transferase%3B Transit peptide.%3B Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)%3B Belongs to the 3-oxoacid CoA-transferase family%3B KEGG: cne:CNL05860 3-oxoacid CoA-transferase gene gene-HME7025_01871 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01871 HME7025_01872 HME7025_01872 HME7025_01872 2193501 2194826 + putative transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Probable amino-acid or metabolite transport protein. Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene-HME7025_01872 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01872 HME7025_01873 HME7025_01873 HME7025_01873 2194842 2196197 + Glutamate--ammonia ligase ATP-binding%3B Ligase%3B Nucleotide-binding.%3B Belongs to the glutamine synthetase family%3B KEGG: srd:SD10_27970 glutamine synthetase gene gene-HME7025_01873 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01873 HME7025_01874 HME7025_01874 HME7025_01874 2196219 2197364 + Alcohol dehydrogenase Cytoplasm%3B Magnesium%3B Methanol utilization%3B NAD%3B Oxidoreductase%3B Zinc.%3B Catalyzes the oxidation of methanol to yield formaldehyde. It possesses a NADH-dependent formaldehyde reductase activity and can not use NADP%3B Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: ddf:DEFDS_0763 alcohol dehydrogenase gene gene-HME7025_01874 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01874 HME7025_01875 HME7025_01875 HME7025_01875 2197368 2198081 + Putative glutamine amidotransferase-like protein YvdE Glutamine amidotransferase%3B Transferase.%3B Contains 1 glutamine amidotransferase type-1 domain gene gene-HME7025_01875 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01875 HME7025_01876 HME7025_01876 aldA aldA 2198084 2199451 + Lactaldehyde dehydrogenase NAD%3B Oxidoreductase.%3B Acts on lactaldehyde as well as other aldehydes. Belongs to the aldehyde dehydrogenase family%3B KEGG: eco:b1415 lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase gene gene-HME7025_01876 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01876 HME7025_01877 HME7025_01877 HME7025_01877 2199570 2201495 + hypothetical protein gene gene-HME7025_01877 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01877 HME7025_01878 HME7025_01878 yahK yahK 2201676 2202719 + NADP-dependent alcohol dehydrogenase Metal-binding%3B NADP%3B Oxidoreductase%3B Phosphoprotein%3B Zinc.%3B NADP-dependent alcohol dehydrogenase with a broad substrate specificity. Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: sgn:SGRA_1245 uncharacterized zinc-type alcohol dehydrogenase-like protein%3B Oxidoreductases gene gene-HME7025_01878 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01878 HME7025_01879 HME7025_01879 HME7025_01879 2202811 2203890 + hypothetical protein gene gene-HME7025_01879 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01879 HME7025_01880 HME7025_01880 HME7025_01880 2203887 2205146 + putative ABC transporter permease Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the ABC-4 integral membrane protein family gene gene-HME7025_01880 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01880 HME7025_01881 HME7025_01881 lolD lolD 2205148 2205828 + Lipoprotein-releasing system ATP-binding protein LolD ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain%3B KEGG: nko:Niako_1906 lipoprotein-releasing system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene-HME7025_01881 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01881 HME7025_01882 HME7025_01882 HME7025_01882 2205829 2206878 - O-acetyltransferase WecH Acyltransferase%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. Catalyzes the acetylation of both cyclic ECA (ECA(CYC)) and phosphoglyceride-linked ECA (ECA(PG))%3B Belongs to the acyltransferase 3 family gene gene-HME7025_01882 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01882 HME7025_01883 HME7025_01883 HME7025_01883 2206865 2208994 - Isoquinoline 1-oxidoreductase Oxidoreductase.%3B KEGG: dfe:Dfer_3445 isoquinoline 1-oxidoreductase%2C beta subunit gene gene-HME7025_01883 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01883 HME7025_01884 HME7025_01884 xdhA xdhA 2208997 2209482 - Xanthine dehydrogenase 2Fe-2S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase.%3B Specific towards N-containing N-heterocyclic substrates%2C including isoquinoline%2C isoquinolin-5-ol%2C phthalazine and quinazoline. Contains 1 2Fe-2S ferredoxin-type domain%3B KEGG: hcs:FF32_14400 xanthine dehydrogenase small subunit gene gene-HME7025_01884 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01884 HME7025_01885 HME7025_01885 HME7025_01885 2209514 2212558 - hypothetical protein gene gene-HME7025_01885 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01885 HME7025_01886 HME7025_01886 HME7025_01886 2212603 2213859 - Inositol 2-dehydrogenase NAD%3B Oxidoreductase.%3B Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: yal:AT01_2642 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_01886 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01886 HME7025_01887 HME7025_01887 HME7025_01887 2214152 2214703 - hypothetical protein gene gene-HME7025_01887 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01887 HME7025_01888 HME7025_01888 HME7025_01888 2214700 2216061 - Lactate utilization protein 4Fe-4S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Repeat%3B Transport.%3B Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate%3B Belongs to the LutB/YkgF family%3B Contains 2 4Fe-4S ferredoxin-type domains gene gene-HME7025_01888 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01888 HME7025_01889 HME7025_01889 HME7025_01889 2216054 2216770 - Lactate utilization protein Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source%3B Belongs to the LutA/YkgE family gene gene-HME7025_01889 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01889 HME7025_01890 HME7025_01890 HME7025_01890 2216761 2218152 - hypothetical protein gene gene-HME7025_01890 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01890 HME7025_01891 HME7025_01891 rhaA rhaA 2218155 2219426 - putative sugar isomerase Isomerase%3B Manganese%3B Metal-binding.%3B Belongs to the rhamnose isomerase family%3B KEGG: rsi:Runsl_1174 L-rhamnose isomerase / sugar isomerase gene gene-HME7025_01891 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01891 HME7025_01892 HME7025_01892 HME7025_01892 2219442 2221565 - putative oxidoreductase YuxG Oxidoreductase.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: ret:RHE_PE00291 null%3B Oxidoreductases gene gene-HME7025_01892 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01892 HME7025_01893 HME7025_01893 HME7025_01893 2221641 2222975 - Hippurate hydrolase Hydrolase.%3B Belongs to the peptidase M20 family%3B KEGG: rpi:Rpic_2778 hippurate hydrolase gene gene-HME7025_01893 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01893 HME7025_01894 HME7025_01894 HME7025_01894 2223107 2224030 - hypothetical protein gene gene-HME7025_01894 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01894 HME7025_01895 HME7025_01895 HME7025_01895 2224162 2225418 + putative AAA domain-containing protein YrvN ATP-binding%3B Nucleotide-binding.%3B Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily gene gene-HME7025_01895 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01895 HME7025_01896 HME7025_01896 thiN thiN 2225415 2226074 - Thiamine diphosphokinase KEGG: dfe:Dfer_4449 thiamine pyrophosphokinase gene gene-HME7025_01896 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01896 HME7025_01897 HME7025_01897 moaC moaC 2226076 2226549 - Cyclic pyranopterin phosphate synthase Cytoplasm%3B GTP-binding%3B Magnesium%3B Metal-binding%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B Transferase.%3B Together with MoaA%2C is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)%3B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor%3B In the N-terminal sectio%3B belongs to the MoaC family%3B In the C-terminal sectio%3B belongs to the MobA family%3B KEGG: caa:Caka_0334 cyclic pyranopterin phosphate synthase gene gene-HME7025_01897 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01897 HME7025_01898 HME7025_01898 moeA moeA 2226637 2227794 + Molybdopterin molybdotransferase Magnesium%3B Metal-binding%3B Molybdenum%3B Molybdenum cofactor biosynthesis%3B Transferase.%3B Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP%3B Belongs to the MoeA family%3B KEGG: cace:CACET_c04490 molybdopterin molybdotransferase gene gene-HME7025_01898 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01898 HME7025_01899 HME7025_01899 catB catB 2227797 2228819 + Muconate cycloisomerase Cell wall biogenesis/degradation%3B Isomerase%3B Magnesium%3B Metal-binding.%3B Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L- Glu and may play a role in the metabolism of the murein peptide%2C of which L-Ala-D-Glu is a component. Is also able to catalyze the epimerization of L-Ala-D-Asp%2C L-Ala-L-Glu%2C L-Ala-L-Ser%2C L-Ala-L- Pro%2C L-Ala-L-L-Val%2C L-Ala-L-Thr%2C L-Ala-L-Leu%2C L-Ala-L-Ile and L- Gly-L-Glu (in vitro)%3B Belongs to the mandelate racemase/muconate lactonizing enzyme family%3B KEGG: sfo:Z042_01320 muconate cycloisomerase gene gene-HME7025_01899 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01899 HME7025_01900 HME7025_01900 bioF bioF 2228812 2229819 + 8-amino-7-oxononanoate synthase KEGG: csk:ES15_2664 8-amino-7-oxononanoate synthase gene gene-HME7025_01900 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01900 HME7025_01901 HME7025_01901 umpA umpA 2229834 2230664 - Prolipoprotein diacylglyceryl transferase Cell inner membrane%3B Cell membrane%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins%3B Belongs to the Lgt family%3B KEGG: hya:HY04AAS1_1235 phosphatidylglycerol:prolipoprotein diacylglycerol transferase%3B Transferases gene gene-HME7025_01901 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01901 HME7025_01902 HME7025_01902 HME7025_01902 2230741 2230884 - hypothetical protein gene gene-HME7025_01902 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01902 HME7025_01903 HME7025_01903 HME7025_01903 2231089 2232261 + hypothetical protein gene gene-HME7025_01903 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01903 HME7025_01904 HME7025_01904 HME7025_01904 2232274 2232897 + hypothetical protein gene gene-HME7025_01904 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01904 HME7025_01905 HME7025_01905 HME7025_01905 2233035 2233868 + hypothetical protein gene gene-HME7025_01905 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01905 HME7025_01906 HME7025_01906 HME7025_01906 2233873 2234862 + uncharacterized protein gene gene-HME7025_01906 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01906 HME7025_01907 HME7025_01907 HME7025_01907 2234862 2235899 + uncharacterized protein KEGG: sdq:SDSE167_0818 glucosyltransferase%3B Hexosyltransferases gene gene-HME7025_01907 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01907 HME7025_01908 HME7025_01908 HME7025_01908 2235975 2239028 + Quinoprotein glucose dehydrogenase (PQQ%2C quinone) KEGG: rba:RB1988 quinoprotein glucose dehydrogenase gene gene-HME7025_01908 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01908 HME7025_01909 HME7025_01909 HME7025_01909 2239031 2239960 + Hydroxypyruvate isomerase Isomerase.%3B Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization of D-fructose to D-glucose or that of D-xylulose to D-xylose. Also does not catalyze racemization of serine%2C alanine%2C glycerate or lactate%3B Belongs to the hyi family%3B KEGG: nso:NIASO_13050 hydroxypyruvate isomerase gene gene-HME7025_01909 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01909 HME7025_01910 HME7025_01910 HME7025_01910 2240024 2240311 + Transcriptional repressor SdpR Cytoplasm%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation.%3B Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation%3B Contains 1 HTH arsR-type DNA-binding domain gene gene-HME7025_01910 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01910 HME7025_01911 HME7025_01911 HME7025_01911 2240369 2240926 + hypothetical protein gene gene-HME7025_01911 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01911 HME7025_01912 HME7025_01912 HME7025_01912 2240923 2242188 - hypothetical protein gene gene-HME7025_01912 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01912 HME7025_01913 HME7025_01913 HME7025_01913 2242169 2242966 - hypothetical protein gene gene-HME7025_01913 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01913 HME7025_01914 HME7025_01914 HME7025_01914 2242953 2243777 - Molybdenum cofactor sulfurase Molybdenum cofactor biosynthesis%3B Phosphoprotein%3B Pyridoxal phosphate%3B Transferase.%3B Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily%3B Contains 1 MOSC domain gene gene-HME7025_01914 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01914 HME7025_01915 HME7025_01915 HME7025_01915 2243896 2245215 + hypothetical protein gene gene-HME7025_01915 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01915 HME7025_01916 HME7025_01916 HME7025_01916 2245186 2246997 - ABC transporter B family member ATP-binding%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Vacuole.%3B Probably involved in redistribution of internalized aluminum. May mediate vacuolar sequestration of a metal complex%3B Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3. A. 1. 201) subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene-HME7025_01916 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01916 HME7025_01917 HME7025_01917 HME7025_01917 2247088 2248251 + N utilization substance protein B like protein Transcription%3B Transcription regulation%3B Transcription termination.%3B Involved in the transcription termination process%3B Belongs to the NusB family gene gene-HME7025_01917 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01917 HME7025_01918 HME7025_01918 HME7025_01918 2248253 2248552 + hypothetical protein gene gene-HME7025_01918 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01918 HME7025_01919 HME7025_01919 HME7025_01919 2248554 2248991 + hypothetical protein gene gene-HME7025_01919 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01919 HME7025_01920 HME7025_01920 HME7025_01920 2249008 2249298 + UPF0092 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0092 family gene gene-HME7025_01920 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01920 HME7025_01921 HME7025_01921 HME7025_01921 2249303 2250724 + Dephospho-CoA kinase ATP-binding%3B Coenzyme A biosynthesis%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A%3B Belongs to the CoaE family%3B Contains 1 DPCK (dephospho-CoA kinase) domain%3B KEGG: chy:CHY_1647 dephospho-CoA kinase gene gene-HME7025_01921 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01921 HME7025_01922 HME7025_01922 dnaX dnaX 2250765 2252561 + DNA-directed DNA polymerase ATP-binding%3B DNA replication%3B DNA-directed DNA polymerase%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. Belongs to the DnaX/STICHEL family%3B KEGG: bth:BT_1610 DNA polymerase III subunit gamma/tau gene gene-HME7025_01922 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01922 HME7025_01923 HME7025_01923 HME7025_01923 2252558 2252863 - hypothetical protein gene gene-HME7025_01923 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01923 HME7025_01924 HME7025_01924 HME7025_01924 2252844 2253182 - hypothetical protein gene gene-HME7025_01924 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01924 HME7025_01925 HME7025_01925 HME7025_01925 2253356 2253892 - hypothetical protein gene gene-HME7025_01925 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01925 HME7025_01926 HME7025_01926 HME7025_01926 2253983 2254279 + hypothetical protein gene gene-HME7025_01926 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01926 HME7025_01927 HME7025_01927 HME7025_01927 2254281 2254715 - hypothetical protein gene gene-HME7025_01927 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01927 HME7025_01928 HME7025_01928 proA proA 2254758 2256014 - Glutamate-5-semialdehyde dehydrogenase Amino-acid biosynthesis%3B Cytoplasm%3B NADP%3B Oxidoreductase%3B Proline biosynthesis.%3B Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate%3B Belongs to the gamma-glutamyl phosphate reductase family%3B KEGG: lby:Lbys_1954 glutamate-5-semialdehyde dehydrogenase gene gene-HME7025_01928 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01928 HME7025_01929 HME7025_01929 HME7025_01929 2256028 2259090 - hypothetical protein gene gene-HME7025_01929 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01929 HME7025_01930 HME7025_01930 HME7025_01930 2259139 2260179 - hypothetical protein gene gene-HME7025_01930 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01930 HME7025_01931 HME7025_01931 HME7025_01931 2260166 2260852 - UMP/CMP kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Belongs to the cytidylate kinase family. Type 1 subfamily%3B KEGG: puf:UFO1_2021 cytidylate kinase gene gene-HME7025_01931 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01931 HME7025_01932 HME7025_01932 HME7025_01932 2260845 2261567 - hypothetical protein gene gene-HME7025_01932 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01932 HME7025_01933 HME7025_01933 HME7025_01933 2261569 2262093 - hypothetical protein gene gene-HME7025_01933 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01933 HME7025_01934 HME7025_01934 HME7025_01934 2262101 2263351 - ATP-dependent Clp protease ATP-binding subunit ClpX ATP-binding%3B Chaperone%3B Metal-binding%3B Nucleotide-binding%3B Zinc%3B Zinc-finger.%3B ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP%3B Belongs to the ClpX chaperone family gene gene-HME7025_01934 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01934 HME7025_01935 HME7025_01935 clpP clpP 2263354 2264061 - Endopeptidase Clp Cytoplasm%3B Hydrolase%3B Protease%3B Serine protease.%3B Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins%3B Belongs to the peptidase S14 family%3B KEGG: chu:CHU_1706 ATP-dependent Clp protease%2C protease subunit gene gene-HME7025_01935 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01935 HME7025_01936 HME7025_01936 HME7025_01936 2264203 2265543 - Trigger factor Cell cycle%3B Cell division%3B Chaperone%3B Cytoplasm%3B Isomerase%3B Rotamase.%3B Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase%3B Belongs to the FKBP-type PPIase family. Tig subfamily%3B Contains 1 PPIase FKBP-type domain gene gene-HME7025_01936 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01936 HME7025_01937 HME7025_01937 HME7025_01937 2265611 2265695 - tRNA-Leu tRNA gene-HME7025_01937 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01937 HME7025_01938 HME7025_01938 HME7025_01938 2265999 2267690 + Sodium/iodide cotransporter Congenital hypothyroidism%3B Disease mutation%3B Glycoprotein%3B Ion transport%3B Membrane%3B Phosphoprotein%3B Polymorphism%3B Sodium%3B Sodium transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Mediates iodide uptake in the thyroid gland. Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene-HME7025_01938 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01938 HME7025_01939 HME7025_01939 ppiB ppiB 2267674 2268249 - Peptidylprolyl isomerase KEGG: pko:PKOR_01490 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) gene gene-HME7025_01939 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01939 HME7025_01940 HME7025_01940 HME7025_01940 2268297 2269508 - hypothetical protein gene gene-HME7025_01940 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01940 HME7025_01941 HME7025_01941 HME7025_01941 2269722 2270918 + putative oxidoreductase Oxidoreductase%3B Plasmid%3B Signal.%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: ret:RHE_CH03642 null%3B With NAD(+) or NADP(+) as acceptor gene gene-HME7025_01941 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01941 HME7025_01942 HME7025_01942 HME7025_01942 2270930 2272075 + Inositol 2-dehydrogenase Cytoplasm%3B Nucleus%3B Oxidoreductase%3B Signal.%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: pac:PPA0469 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_01942 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01942 HME7025_01943 HME7025_01943 HME7025_01943 2272081 2273133 + Myo-inosose-2 dehydratase KEGG: cmi:CMM_0794 inosose dehydratase gene gene-HME7025_01943 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01943 HME7025_01944 HME7025_01944 dnaG dnaG 2273378 2275342 - DNA primase DNA replication%3B DNA-binding%3B DNA-directed RNA polymerase%3B Magnesium%3B Metal-binding%3B Nucleotidyltransferase%3B Primosome%3B Transcription%3B Transferase%3B Zinc%3B Zinc-finger.%3B RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication%3B Belongs to the DnaG primase family%3B Contains 1 Toprim domain%3B KEGG: cco:CCC13826_0795 DNA primase%3B Nucleotidyltransferases gene gene-HME7025_01944 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01944 HME7025_01945 HME7025_01945 HME7025_01945 2275347 2276585 - putative transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene-HME7025_01945 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01945 HME7025_01946 HME7025_01946 HME7025_01946 2276612 2278900 - Polyphosphate kinase ATP-binding%3B Kinase%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase.%3B Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)%3B Belongs to the polyphosphate kinase family%3B KEGG: hsw:Hsw_2629 polyphosphate kinase gene gene-HME7025_01946 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01946 HME7025_01947 HME7025_01947 HME7025_01947 2278908 2279120 - hypothetical protein gene gene-HME7025_01947 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01947 HME7025_01948 HME7025_01948 gyrB gyrB 2279124 2281091 - DNA topoisomerase (ATP-hydrolyzing) ATP-binding%3B Cytoplasm%3B DNA-binding%3B Isomerase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Topoisomerase.%3B DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the type II topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: pce:PECL_6 DNA gyrase subunit B gene gene-HME7025_01948 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01948 HME7025_01949 HME7025_01949 purH purH 2281232 2282752 - Phosphoribosylaminoimidazolecarboxamide formyltransferase Hydrolase%3B Multifunctional enzyme%3B Purine biosynthesis%3B Transferase.%3B Belongs to the PurH family%3B KEGG: evi:Echvi_1469 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase gene gene-HME7025_01949 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01949 HME7025_01950 HME7025_01950 HME7025_01950 2282933 2284162 - Unsaturated chondroitin disaccharide hydrolase Carbohydrate metabolism%3B Glycosidase%3B Hydrolase%3B Polysaccharide degradation%3B Virulence.%3B Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides. Also degrades unsaturated heparin disaccharides. Releases 4-deoxy-4%2C5-didehydro D-glucuronic acid or 4-deoxy-4%2C5-didehydro L-iduronic acid from chondroitin disaccharides%2C hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans. Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such as chondroitin and hyaluronan%3B Belongs to the glycosyl hydrolase 88 family%3B KEGG: age:AA314_03425 unsaturated chondroitin disaccharide hydrolase gene gene-HME7025_01950 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01950 HME7025_01951 HME7025_01951 kduD kduD 2284197 2284952 - 2-deoxy-D-gluconate 3-dehydrogenase NADP%3B Oxidoreductase.%3B Involved in the conversion of versicolorin A to 6- demethylsterigmatocystin in the aflatoxin biosynthesis pathway%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pmr:PMI2132 2-deoxy-D-gluconate 3-dehydrogenase gene gene-HME7025_01951 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01951 HME7025_01952 HME7025_01952 HME7025_01952 2285136 2285348 + hypothetical protein gene gene-HME7025_01952 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01952 HME7025_01953 HME7025_01953 HME7025_01953 2285351 2285971 + hypothetical protein gene gene-HME7025_01953 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01953 HME7025_01954 HME7025_01954 HME7025_01954 2286002 2286847 - putative HTH-type transcriptional regulator YbfI DNA-binding%3B Repeat%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene-HME7025_01954 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01954 HME7025_01955 HME7025_01955 HME7025_01955 2286979 2287944 + hypothetical protein gene gene-HME7025_01955 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01955 HME7025_01956 HME7025_01956 HME7025_01956 2287983 2289329 - Unsaturated rhamnogalacturonyl hydrolase Cytoplasm%3B Glycosidase%3B Hydrolase.%3B Catalyzes the hydrolysis of unsaturated rhamnogalacturonan disaccharide to yield unsaturated D- galacturonic acid and L-rhamnose. It cannot act on unsaturated glucuronyl hydrolase (UGL) substrates containing unsaturated D- glucuronic acid at the non-reducing terminus%2C although the active pockets of YesR and UGL are very similar%3B Belongs to the glycosyl hydrolase 105 family%3B KEGG: ttm:Tthe_2402 unsaturated rhamnogalacturonyl hydrolase gene gene-HME7025_01956 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01956 HME7025_01957 HME7025_01957 HME7025_01957 2289340 2289444 - hypothetical protein gene gene-HME7025_01957 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01957 HME7025_01958 HME7025_01958 HME7025_01958 2289456 2292269 - hypothetical protein gene gene-HME7025_01958 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01958 HME7025_01959 HME7025_01959 iaaA iaaA 2292476 2292901 + Beta-aspartyl-peptidase KEGG: rba:RB7985 beta-aspartyl-peptidase (threonine type) gene gene-HME7025_01959 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01959 HME7025_01960 HME7025_01960 HME7025_01960 2292882 2293496 - Arsenate reductase (glutaredoxin) KEGG: zpr:ZPR_0758 arsenate reductase gene gene-HME7025_01960 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01960 HME7025_01961 HME7025_01961 HME7025_01961 2293560 2294423 - Diacylglycerol kinase (ATP) KEGG: siv:SSIL_0530 diacylglycerol kinase (ATP) gene gene-HME7025_01961 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01961 HME7025_01962 HME7025_01962 HME7025_01962 2294427 2294855 - IMP dehydrogenase CBS domain%3B Repeat.%3B Contains 2 CBS domains%3B KEGG: bma:BMAA1350 IMP dehydrogenase gene gene-HME7025_01962 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01962 HME7025_01963 HME7025_01963 HME7025_01963 2294965 2295699 - hypothetical protein gene gene-HME7025_01963 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01963 HME7025_01964 HME7025_01964 HME7025_01964 2295863 2296579 + 3-oxoacyl-[acyl-carrier-protein] reductase Antibiotic biosynthesis%3B NAD%3B Oxidoreductase.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: bpe:BP1668 3-oxoacyl-(acyl-carrier protein) reductase gene gene-HME7025_01964 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01964 HME7025_01965 HME7025_01965 HME7025_01965 2296658 2297974 + hypothetical protein gene gene-HME7025_01965 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01965 HME7025_01966 HME7025_01966 scrK scrK 2297971 2298921 + Fructokinase Kinase%3B Transferase.%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: pat:Patl_4122 fructokinase gene gene-HME7025_01966 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01966 HME7025_01967 HME7025_01967 HME7025_01967 2298928 2300859 + Amylosucrase Glycosyltransferase%3B Secreted%3B Transferase.%3B Catalyzes the synthesis of alpha-glucan from sucrose. Catalyzes%2C in addition%2C sucrose hydrolysis%2C maltose and maltotriose synthesis by successive transfers of the glucosyl moiety of sucrose onto the released glucose%2C and finally turanose and trehalulose synthesis%2C these two sucrose isomers being obtained by glucosyl transfer onto fructose (By similarity)%3B Belongs to the glycosyl hydrolase 13 family%3B KEGG: alv:Alvin_0245 amylosucrase gene gene-HME7025_01967 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01967 HME7025_01968 HME7025_01968 HME7025_01968 2300876 2301766 - hypothetical protein gene gene-HME7025_01968 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01968 HME7025_01969 HME7025_01969 HME7025_01969 2301941 2303023 + Inositol 2-dehydrogenase NAD%3B Oxidoreductase.%3B Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: ase:ACPL_2914 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_01969 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01969 HME7025_01970 HME7025_01970 apeH apeH 2303084 2305129 - Acylaminoacyl-peptidase Aminopeptidase%3B Glycoprotein%3B Hydrolase%3B Protease%3B Secreted%3B Serine protease%3B Signal%3B Virulence.%3B Extracellular dipeptidyl-peptidase which removes N- terminal dipeptides sequentially from polypeptides having unsubstituted N-termini. Contributes to pathogenicity (By similarity)%3B Belongs to the peptidase S9B family%3B KEGG: ccs:CCNA_02065 acylaminoacyl-peptidase gene gene-HME7025_01970 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01970 HME7025_01971 HME7025_01971 pepO pepO 2305187 2307220 + Endothelin-converting enzyme Alternative splicing%3B Glycoprotein%3B Golgi apparatus%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Methyltransferase%3B Multifunctional enzyme%3B Phosphoprotein%3B Polymorphism%3B Protease%3B Signal-anchor%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Zinc.%3B Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides%2C including neurotensin%2C angiotensin I%2C substance P%2C proenkephalin-derived peptides%2C and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity%3B In the N-terminal sectio%3B belongs to the methyltransferase superfamily%3B In the C-terminal sectio%3B belongs to the peptidase M13 family%3B KEGG: shg:Sph21_4637 putative endopeptidase%3B Metalloendopeptidases gene gene-HME7025_01971 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01971 HME7025_01972 HME7025_01972 HME7025_01972 2307582 2309027 - hypothetical protein gene gene-HME7025_01972 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01972 HME7025_01973 HME7025_01973 HME7025_01973 2309046 2312195 - TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_01973 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01973 HME7025_01974 HME7025_01974 HME7025_01974 2312374 2313804 - hypothetical protein gene gene-HME7025_01974 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01974 HME7025_01975 HME7025_01975 HME7025_01975 2313826 2317032 - TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_01975 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01975 HME7025_01976 HME7025_01976 HME7025_01976 2317239 2318552 - Gluconate permease Cell membrane%3B Gluconate utilization%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the GntP permease family gene gene-HME7025_01976 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01976 HME7025_01977 HME7025_01977 glgC glgC 2318722 2319588 - Glucose-1-phosphate adenylyltransferase KEGG: fae:FAES_2079 glucose-1-phosphate adenylyltransferase gene gene-HME7025_01977 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01977 HME7025_01978 HME7025_01978 galK galK 2319597 2320673 - Galactokinase ATP-binding%3B Cytoplasm%3B Isoprene biosynthesis%3B Kinase%3B Lipid biosynthesis%3B Lipid metabolism%3B Magnesium%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP)%2C a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids%3B Belongs to the GHMP kinase family. Mevalonate kinase subfamily%3B KEGG: dfe:Dfer_0465 galactokinase gene gene-HME7025_01978 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01978 HME7025_01979 HME7025_01979 HME7025_01979 2320752 2321837 + hypothetical protein gene gene-HME7025_01979 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01979 HME7025_01980 HME7025_01980 HME7025_01980 2321940 2322335 - hypothetical protein gene gene-HME7025_01980 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01980 HME7025_01981 HME7025_01981 HME7025_01981 2322335 2323648 - hypothetical protein gene gene-HME7025_01981 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01981 HME7025_01982 HME7025_01982 ppoX ppoX 2323715 2324923 - Protoporphyrinogen oxidase Antibiotic%3B Antimicrobial%3B Apoptosis%3B Cytolysis%3B Disulfide bond%3B FAD%3B Flavoprotein%3B Glycoprotein%3B Hemolysis%3B Hemostasis impairing toxin%3B Oxidoreductase%3B Platelet aggregation inhibiting toxin%3B Secreted%3B Signal%3B Toxin.%3B Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids%2C thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Unlike most snake L-amino-acid oxidases%2C this enzyme exhibits potent activity against L-Lys. Has also potent activity against L-Met%2C L-Leu%2C L-His%2C L-Lys and L-Ile. Its activity on platelet aggregation is controversial. It has potent inhibitory activity on platelet aggregation induced by ADP and the thromboxane analog U46619%2C but not by thrombin%2C mucetin%2C ristocetin and stejnulxin (PubMed:17543361)%2C but it has also been shown to induce platelet aggregation through the formation of hydrogen peroxide (PubMed:7886693). It binds to bacteria and shows antibacterial activities by generating hydrogen peroxide. Binding and antibacterial activities are higher against Gram-positive than against Gram-negative bacteria. May also have an ability to induce hemorrhage%2C hemolysis%2C edema%2C apoptosis%3B Belongs to the flavin monoamine oxidase family. FIG1 subfamily%3B KEGG: pru:PRU_2785 oxygen-dependent protoporphyrinogen oxidase gene gene-HME7025_01982 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01982 HME7025_01983 HME7025_01983 menH menH 2325010 2325771 + 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase Aromatic hydrocarbons catabolism%3B Hydrolase%3B Plasmid%3B Serine esterase.%3B Catalyzes the conversion of 2-hydroxymuconate semialdehyde to 2-hydroxypent-2%2C4-dienoate. Belongs to the DmpD/TodF/XylF esterase family%3B KEGG: rca:Rcas_1310 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase gene gene-HME7025_01983 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01983 HME7025_01984 HME7025_01984 HME7025_01984 2325747 2326442 + hypothetical protein gene gene-HME7025_01984 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01984 HME7025_01985 HME7025_01985 ppnK ppnK 2326445 2327326 + NAD(+) kinase ATP-binding%3B Cytoplasm%3B Kinase%3B NAD%3B NADP%3B Nucleotide-binding%3B Transferase.%3B Involved in the regulation of the intracellular balance of NAD and NADP%2C and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP%3B Belongs to the NAD kinase family%3B KEGG: rsi:Runsl_2223 NAD+ kinase gene gene-HME7025_01985 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01985 HME7025_01986 HME7025_01986 HME7025_01986 2327444 2330089 - DNA mismatch repair protein MutS ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Nucleotide-binding.%3B This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity%3B Belongs to the DNA mismatch repair MutS family gene gene-HME7025_01986 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01986 HME7025_01987 HME7025_01987 choD choD 2330384 2332138 + Cholesterol oxidase KEGG: pfe:PSF113_5443 cholesterol oxidase gene gene-HME7025_01987 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01987 HME7025_01988 HME7025_01988 HME7025_01988 2332138 2332776 + hypothetical protein gene gene-HME7025_01988 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01988 HME7025_01989 HME7025_01989 HME7025_01989 2332769 2333515 + Laccase domain protein YlmD Belongs to the LACC1 family gene gene-HME7025_01989 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01989 HME7025_01990 HME7025_01990 HME7025_01990 2333715 2333867 + hypothetical protein gene gene-HME7025_01990 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01990 HME7025_01991 HME7025_01991 HME7025_01991 2333924 2334790 + hypothetical protein gene gene-HME7025_01991 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01991 HME7025_01992 HME7025_01992 HME7025_01992 2334807 2336075 + hypothetical protein gene gene-HME7025_01992 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01992 HME7025_01993 HME7025_01993 HME7025_01993 2336079 2336798 + hypothetical protein gene gene-HME7025_01993 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01993 HME7025_01994 HME7025_01994 HME7025_01994 2336803 2337633 + hypothetical protein gene gene-HME7025_01994 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01994 HME7025_01995 HME7025_01995 HME7025_01995 2337635 2338798 + hypothetical protein gene gene-HME7025_01995 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01995 HME7025_01996 HME7025_01996 HME7025_01996 2338795 2340906 + hypothetical protein gene gene-HME7025_01996 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01996 HME7025_01997 HME7025_01997 HME7025_01997 2340913 2341635 - hypothetical protein gene gene-HME7025_01997 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01997 HME7025_01998 HME7025_01998 cds1 cds1 2341691 2342521 - Phosphatidate cytidylyltransferase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Nucleotidyltransferase%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the CDS family%3B KEGG: dfe:Dfer_2993 phosphatidate cytidylyltransferase gene gene-HME7025_01998 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01998 HME7025_01999 HME7025_01999 HME7025_01999 2342531 2342737 - hypothetical protein gene gene-HME7025_01999 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_01999 HME7025_02000 HME7025_02000 HME7025_02000 2342734 2343684 - hypothetical protein gene gene-HME7025_02000 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02000 HME7025_02001 HME7025_02001 HME7025_02001 2343718 2344710 + tRNA-dihydrouridine synthase B Flavoprotein%3B FMN%3B NADP%3B Oxidoreductase%3B RNA-binding%3B tRNA processing%3B tRNA-binding.%3B Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines%3B Belongs to the Dus family. DusB subfamily%3B KEGG: gfo:GFO_3332 null%3B Oxidoreductases gene gene-HME7025_02001 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02001 HME7025_02002 HME7025_02002 HME7025_02002 2344715 2345602 + hypothetical protein gene gene-HME7025_02002 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02002 HME7025_02003 HME7025_02003 HME7025_02003 2345704 2346972 + hypothetical protein gene gene-HME7025_02003 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02003 HME7025_02004 HME7025_02004 HME7025_02004 2346964 2348727 - hypothetical protein gene gene-HME7025_02004 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02004 HME7025_02005 HME7025_02005 HME7025_02005 2348805 2349503 + Beta-carotene ketolase Carotenoid biosynthesis%3B Oxidoreductase. gene gene-HME7025_02005 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02005 HME7025_02006 HME7025_02006 pyrH pyrH 2349556 2350266 + UMP kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Pyrimidine biosynthesis%3B Transferase.%3B Catalyzes the reversible phosphorylation of UMP to UDP%3B Belongs to the UMP kinase family%3B KEGG: mmy:MSC_0601 uridylate kinase gene gene-HME7025_02006 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02006 HME7025_02007 HME7025_02007 HME7025_02007 2350284 2350844 + Ribosome-recycling factor Cytoplasm%3B Protein biosynthesis.%3B Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another%3B Belongs to the RRF family gene gene-HME7025_02007 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02007 HME7025_02008 HME7025_02008 HME7025_02008 2350923 2351810 - hypothetical protein gene gene-HME7025_02008 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02008 HME7025_02009 HME7025_02009 ispB ispB 2351896 2352870 + All-trans-octaprenyl-diphosphate synthase Lipid biosynthesis%3B Lipid metabolism%3B Magnesium%3B Metal-binding%3B Transferase.%3B Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylgeranyl diphosphate (GGPP) which is a precursor of the ether-linked lipids%3B Belongs to the FPP/GGPP synthase family%3B KEGG: lby:Lbys_2917 octaprenyl-diphosphate synthase gene gene-HME7025_02009 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02009 HME7025_02010 HME7025_02010 HME7025_02010 2352966 2355584 - hypothetical protein gene gene-HME7025_02010 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02010 HME7025_02011 HME7025_02011 rimJ rimJ 2355727 2356287 + Ribosomal-protein-alanine N-acetyltransferase KEGG: ban:BA_2420 ribosomal-protein-alanine N-acetyltransferase gene gene-HME7025_02011 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02011 HME7025_02012 HME7025_02012 argF argF 2356371 2357345 + N-succinylornithine carbamoyltransferase Amino-acid biosynthesis%3B Arginine biosynthesis%3B Cytoplasm%3B Transferase.%3B Catalyzes the conversion of N-acetylornithine to N- acetylcitrulline in an alternative arginine biosynthesis pathway. The enzyme has no activity with ornithine. Belongs to the ATCase/OTCase family%3B KEGG: bvs:BARVI_08565 N-succinyl-L-ornithine transcarbamylase gene gene-HME7025_02012 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02012 HME7025_02013 HME7025_02013 argB argB 2357350 2358135 + Acetylglutamate kinase Amino-acid biosynthesis%3B Arginine biosynthesis%3B ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Belongs to the acetylglutamate kinase family%3B KEGG: shg:Sph21_1039 acetylglutamate kinase gene gene-HME7025_02013 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02013 HME7025_02014 HME7025_02014 argE argE 2358136 2359224 + Acetylornithine deacetylase KEGG: sli:Slin_0306 acetylornithine deacetylase gene gene-HME7025_02014 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02014 HME7025_02015 HME7025_02015 argH argH 2359230 2360573 + Argininosuccinate lyase Amino-acid biosynthesis%3B Arginine biosynthesis%3B Cytoplasm%3B Lyase.%3B Belongs to the lyase 1 family. Argininosuccinate lyase subfamily%3B KEGG: ppn:Palpr_1906 argininosuccinate lyase gene gene-HME7025_02015 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02015 HME7025_02016 HME7025_02016 ribE ribE 2360559 2361146 - Riboflavin synthase Repeat%3B Riboflavin biosynthesis%3B Transferase.%3B Catalyzes the dismutation of two molecules of 6%2C7- dimethyl-8-ribityllumazine%2C resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil%3B Contains 2 lumazine-binding repeats%3B KEGG: rbt:NOVO_08005 riboflavin synthase gene gene-HME7025_02016 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02016 HME7025_02017 HME7025_02017 HME7025_02017 2361196 2361804 + hypothetical protein gene gene-HME7025_02017 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02017 HME7025_02018 HME7025_02018 HME7025_02018 2361801 2362517 - hypothetical protein gene gene-HME7025_02018 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02018 HME7025_02019 HME7025_02019 HME7025_02019 2362584 2365019 - hypothetical protein gene gene-HME7025_02019 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02019 HME7025_02020 HME7025_02020 HME7025_02020 2365032 2365373 - Putative DNA-binding protein YwzG DNA-binding. gene gene-HME7025_02020 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02020 HME7025_02021 HME7025_02021 HME7025_02021 2365515 2366726 + Sensor protein ZraS ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Zinc.%3B Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium (By similarity)%3B Contains 1 histidine kinase domain%3B KEGG: gfo:GFO_3045 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene-HME7025_02021 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02021 HME7025_02022 HME7025_02022 HME7025_02022 2366723 2367649 + hypothetical protein gene gene-HME7025_02022 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02022 HME7025_02023 HME7025_02023 HME7025_02023 2367722 2368447 + Demethylmenaquinone methyltransferase Menaquinone biosynthesis%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Ubiquinone biosynthesis.%3B Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1%2C4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol (DMQH2)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family%3B KEGG: fli:Fleli_0415 demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase gene gene-HME7025_02023 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02023 HME7025_02024 HME7025_02024 HME7025_02024 2368604 2369122 + hypothetical protein gene gene-HME7025_02024 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02024 HME7025_02025 HME7025_02025 HME7025_02025 2369123 2370043 - hypothetical protein gene gene-HME7025_02025 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02025 HME7025_02026 HME7025_02026 HME7025_02026 2370045 2372420 - hypothetical protein gene gene-HME7025_02026 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02026 HME7025_02027 HME7025_02027 HME7025_02027 2372617 2372823 + hypothetical protein gene gene-HME7025_02027 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02027 HME7025_02028 HME7025_02028 HME7025_02028 2372834 2374735 + Glucosamine-6-phosphate deaminase In the N-terminal sectio%3B belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily%3B KEGG: rsi:Runsl_1585 glucosamine-6-phosphate deaminase gene gene-HME7025_02028 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02028 HME7025_02029 HME7025_02029 glcD glcD 2374746 2377670 - (S)-2-hydroxy-acid oxidase FAD%3B Flavoprotein%3B Oxidoreductase.%3B Belongs to the FAD-binding oxidoreductase/transferase type 4 family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: sno:Snov_3891 glycolate oxidase gene gene-HME7025_02029 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02029 HME7025_02030 HME7025_02030 HME7025_02030 2377686 2378351 - hypothetical protein gene gene-HME7025_02030 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02030 HME7025_02031 HME7025_02031 HME7025_02031 2378358 2379368 - Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Glycosyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Lipopolysaccharide biosynthesis%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides%3B Belongs to the glycosyltransferase 2 family%3B KEGG: eca:ECA3145 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase gene gene-HME7025_02031 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02031 HME7025_02032 HME7025_02032 HME7025_02032 2379316 2380908 - hypothetical protein gene gene-HME7025_02032 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02032 HME7025_02033 HME7025_02033 nrdA nrdA 2381000 2383447 - Ribonucleoside-diphosphate reductase Allosteric enzyme%3B ATP-binding%3B Cytoplasm%3B Disulfide bond%3B DNA replication%3B Nucleotide-binding%3B Oxidoreductase.%3B Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. Ribonucleotide reductase (RNR) complex function is essential for efficient organellar DNA degradation in pollen. Involved in chloroplast division%3B Belongs to the ribonucleoside diphosphate reductase large chain family%3B Contains 1 ATP-cone domain%3B KEGG: lxx:Lxx17790 ribonucleoside-diphosphate reductase alpha chain gene gene-HME7025_02033 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02033 HME7025_02034 HME7025_02034 HME7025_02034 2383967 2384212 + 50S ribosomal protein L31 type Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L31P family. Type B subfamily gene gene-HME7025_02034 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02034 HME7025_02035 HME7025_02035 HME7025_02035 2384333 2385427 + Glucose-1-phosphate thymidylyltransferase KEGG: rba:RB4043 glucose-1-phosphate thymidylyltransferase gene gene-HME7025_02035 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02035 HME7025_02036 HME7025_02036 holB holB 2385455 2386588 + DNA-directed DNA polymerase ATP-binding%3B DNA replication%3B DNA-directed DNA polymerase%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Ribosomal frameshifting%3B Transferase.%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. Isoform tau: serves as a scaffold to help in the dimerization of the core complex. Isoform gamma: seems to interact with the delta subunit. to transfer the beta subunit on the DNA. Belongs to the DnaX/STICHEL family%3B KEGG: sfu:Sfum_0156 DNA polymerase III subunit delta' gene gene-HME7025_02036 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02036 HME7025_02037 HME7025_02037 hemC hemC 2386591 2387517 + Hydroxymethylbilane synthase Porphyrin biosynthesis%3B Transferase.%3B Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps%3B Belongs to the HMBS family%3B KEGG: bbd:Belba_0315 hydroxymethylbilane synthase gene gene-HME7025_02037 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02037 HME7025_02038 HME7025_02038 rfbD rfbD 2387535 2388440 + dTDP-4-dehydrorhamnose reductase Lipopolysaccharide biosynthesis%3B NADP%3B Oxidoreductase.%3B Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose%3B Belongs to the dTDP-4-dehydrorhamnose reductase family%3B KEGG: dfe:Dfer_3226 dTDP-4-dehydrorhamnose reductase gene gene-HME7025_02038 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02038 HME7025_02039 HME7025_02039 HME7025_02039 2388437 2389528 - GTPase Obg Cytoplasm%3B GTP-binding%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding.%3B An essential GTPase which binds GTP%2C GDP and possibly (p)ppGpp with moderate affinity%2C with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle%2C stress response%2C ribosome biogenesis and in those bacteria that undergo differentiation%2C in morphogenesis control%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene-HME7025_02039 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02039 HME7025_02040 HME7025_02040 HME7025_02040 2389548 2390183 - Adenylate kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide biosynthesis%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism%3B Belongs to the adenylate kinase family%3B KEGG: ote:Oter_1863 adenylate kinase gene gene-HME7025_02040 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02040 HME7025_02041 HME7025_02041 HME7025_02041 2390380 2393634 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_02041 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02041 HME7025_02042 HME7025_02042 HME7025_02042 2393668 2395443 + hypothetical protein gene gene-HME7025_02042 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02042 HME7025_02043 HME7025_02043 HME7025_02043 2395526 2396452 + uncharacterized protein Belongs to the TolB family gene gene-HME7025_02043 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02043 HME7025_02044 HME7025_02044 HME7025_02044 2396488 2397219 + Protein DrgA Flavoprotein%3B FMN%3B Herbicide resistance%3B NAD%3B NADP%3B Oxidoreductase.%3B Controls resistance to the herbicide Dinoseb and metronidazole. Involved in detoxification of Dinoseb via the reduction of the nitro group(s) and this process is accompanied by the formation of toxic superoxide anions. Belongs to the nitroreductase family%3B KEGG: gym:GYMC10_3877 null%3B Oxidoreductases gene gene-HME7025_02044 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02044 HME7025_02045 HME7025_02045 priA priA 2397220 2399721 - Primosomal protein N' ATP-binding%3B DNA replication%3B DNA-binding%3B Helicase%3B Hydrolase%3B Metal-binding%3B Nucleotide-binding%3B Primosome%3B Zinc%3B Zinc-finger.%3B Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex%2C via its helicase activity%2C and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA%3B Belongs to the helicase family. PriA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: fae:FAES_1154 primosomal protein N' (replication factor Y) (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene-HME7025_02045 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02045 HME7025_02046 HME7025_02046 HME7025_02046 2399783 2400376 - hypothetical protein gene gene-HME7025_02046 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02046 HME7025_02047 HME7025_02047 HME7025_02047 2400385 2401155 - 1-acylglycerol-3-phosphate O-acyltransferase Acyltransferase%3B Endoplasmic reticulum%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Signal%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family%3B KEGG: fli:Fleli_4029 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene-HME7025_02047 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02047 HME7025_02048 HME7025_02048 HME7025_02048 2401196 2402668 - Pyruvate kinase ATP-binding%3B Glycolysis%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Potassium%3B Pyruvate%3B Transferase.%3B Belongs to the pyruvate kinase family%3B KEGG: scd:Spica_0776 pyruvate kinase gene gene-HME7025_02048 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02048 HME7025_02049 HME7025_02049 HME7025_02049 2402767 2403030 - hypothetical protein gene gene-HME7025_02049 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02049 HME7025_02050 HME7025_02050 HME7025_02050 2403168 2404070 - hypothetical protein gene gene-HME7025_02050 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02050 HME7025_02051 HME7025_02051 HME7025_02051 2404084 2405679 - hypothetical protein gene gene-HME7025_02051 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02051 HME7025_02052 HME7025_02052 HME7025_02052 2405712 2406464 - hypothetical protein gene gene-HME7025_02052 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02052 HME7025_02053 HME7025_02053 HME7025_02053 2406505 2407617 - hypothetical protein gene gene-HME7025_02053 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02053 HME7025_02054 HME7025_02054 HME7025_02054 2407778 2408779 - hypothetical protein gene gene-HME7025_02054 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02054 HME7025_02055 HME7025_02055 hemD hemD 2408893 2409681 - Uroporphyrinogen-III synthase KEGG: phe:Phep_0382 uroporphyrinogen-III synthase gene gene-HME7025_02055 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02055 HME7025_02056 HME7025_02056 HME7025_02056 2409773 2410963 - hypothetical protein gene gene-HME7025_02056 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02056 HME7025_02057 HME7025_02057 sucD sucD 2410975 2411853 - Succinate--CoA ligase (ADP-forming) ATP-binding%3B Ligase%3B Nucleotide-binding%3B Phosphoprotein%3B Tricarboxylic acid cycle.%3B Belongs to the succinate/malate CoA ligase alpha subunit family%3B KEGG: eco:b0729 succinyl-CoA synthetase alpha subunit gene gene-HME7025_02057 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02057 HME7025_02058 HME7025_02058 HME7025_02058 2411997 2413661 + DNA repair protein RecN ATP-binding%3B DNA damage%3B DNA repair%3B Nucleotide-binding.%3B May be involved in recombinational repair of damaged DNA%3B Belongs to the RecN family gene gene-HME7025_02058 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02058 HME7025_02059 HME7025_02059 HME7025_02059 2413669 2414070 + hypothetical protein gene gene-HME7025_02059 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02059 HME7025_02060 HME7025_02060 HME7025_02060 2414045 2414683 + SCO1 protein like protein Cell membrane%3B Chaperone%3B Copper%3B Lipoprotein%3B Membrane%3B Metal-binding%3B Palmitate%3B Signal.%3B Neccessary for insertion of copper into the active site of cytochrome c oxidase. May play a role in copper homeostasis or redox signaling%3B Belongs to the SCO1/2 family%3B Contains 1 thioredoxin domain gene gene-HME7025_02060 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02060 HME7025_02061 HME7025_02061 HME7025_02061 2414684 2415115 + Nitrite reductase (NO-forming) KEGG: dji:CH75_00620 nitrite reductase (NO-forming) gene gene-HME7025_02061 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02061 HME7025_02062 HME7025_02062 HME7025_02062 2415112 2415657 - hypothetical protein gene gene-HME7025_02062 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02062 HME7025_02063 HME7025_02063 HME7025_02063 2415668 2417002 - hypothetical protein gene gene-HME7025_02063 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02063 HME7025_02064 HME7025_02064 HME7025_02064 2417095 2418183 + putative MscS family protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the MscS (TC 1. A. 23) family gene gene-HME7025_02064 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02064 HME7025_02065 HME7025_02065 leuA leuA 2418180 2419319 - 2-isopropylmalate synthase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Isoleucine biosynthesis%3B Transferase.%3B Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate%3B Belongs to the alpha-IPM synthase/homocitrate synthase family%3B KEGG: bab:bbp493 2-isopropylmalate synthase gene gene-HME7025_02065 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02065 HME7025_02066 HME7025_02066 ilvC ilvC 2419791 2420834 - Ketol-acid reductoisomerase (NADP(+)) Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Magnesium%3B Metal-binding%3B Mitochondrion%3B NADP%3B Oxidoreductase%3B Phosphoprotein%3B Transit peptide.%3B Belongs to the ketol-acid reductoisomerase family%3B KEGG: dal:Dalk_0563 ketol-acid reductoisomerase gene gene-HME7025_02066 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02066 HME7025_02067 HME7025_02067 ilvH ilvH 2420891 2421424 - Acetolactate synthase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Transferase.%3B Belongs to the acetolactate synthase small subunit family%3B Contains 1 ACT domain%3B KEGG: fps:FP0447 acetolactate synthase I/III small subunit gene gene-HME7025_02067 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02067 HME7025_02068 HME7025_02068 ilvB ilvB 2421432 2423174 - Acetolactate synthase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B FAD%3B Flavoprotein%3B Magnesium%3B Metal-binding%3B Thiamine pyrophosphate%3B Transferase.%3B Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine%2C isoleucine%2C and valine. Also involved in condensing pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate (By similarity)%3B Belongs to the TPP enzyme family%3B KEGG: cti:RALTA_A1770 acetolactate synthase I/II/III large subunit gene gene-HME7025_02068 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02068 HME7025_02069 HME7025_02069 HME7025_02069 2423264 2424940 - Dihydroxy-acid dehydratase 4Fe-4S%3B Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding.%3B Belongs to the IlvD/Edd family%3B KEGG: rta:Rta_16150 dihydroxy-acid dehydratase gene gene-HME7025_02069 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02069 HME7025_02070 HME7025_02070 HME7025_02070 2425060 2426823 - ATP-binding cassette sub-family B member Alternative splicing%3B ATP-binding%3B Lysosome%3B Membrane%3B Nucleotide-binding%3B Peptide transport%3B Polymorphism%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged%2C aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored%3B Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3. A. 1. 209) subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene-HME7025_02070 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02070 HME7025_02071 HME7025_02071 HME7025_02071 2426901 2428100 - L-2-hydroxyglutarate dehydrogenase Acetylation%3B FAD%3B Flavoprotein%3B Mitochondrion%3B Oxidoreductase%3B Transit peptide.%3B Belongs to the L2HGDH family%3B KEGG: cfo:105249825 2-hydroxyglutarate dehydrogenase gene gene-HME7025_02071 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02071 HME7025_02072 HME7025_02072 anmK anmK 2428344 2429540 + Anhydro-N-acetylmuramic acid kinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the specific phosphorylation of 1%2C6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1%2C6-anhydro ring%2C generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling%3B Belongs to the anhydro-N-acetylmuramic acid kinase family%3B KEGG: phe:Phep_4141 anhydro-N-acetylmuramic acid kinase gene gene-HME7025_02072 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02072 HME7025_02073 HME7025_02073 rluC rluC 2429549 2430265 + 23S rRNA pseudouridine(955/2504/2580) synthase Isomerase%3B rRNA processing%3B tRNA processing.%3B Responsible for synthesis of pseudouridine from uracil- 746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: phe:Phep_2521 23S rRNA pseudouridine955/2504/2580 synthase gene gene-HME7025_02073 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02073 HME7025_02074 HME7025_02074 HME7025_02074 2430278 2430352 + tRNA-Arg tRNA gene-HME7025_02074 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02074 HME7025_02075 HME7025_02075 HME7025_02075 2430456 2431982 - hypothetical protein gene gene-HME7025_02075 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02075 HME7025_02076 HME7025_02076 HME7025_02076 2431988 2432332 - hypothetical protein gene gene-HME7025_02076 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02076 HME7025_02077 HME7025_02077 HME7025_02077 2432434 2433957 - Site-specific DNA-methyltransferase (cytosine-N(4)-specific) KEGG: nos:Nos7107_0781 site-specific DNA-methyltransferase (cytosine-N4-specific) gene gene-HME7025_02077 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02077 HME7025_02078 HME7025_02078 HME7025_02078 2434180 2434836 - hypothetical protein gene gene-HME7025_02078 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02078 HME7025_02079 HME7025_02079 HME7025_02079 2435096 2435824 - hypothetical protein gene gene-HME7025_02079 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02079 HME7025_02080 HME7025_02080 HME7025_02080 2436532 2437149 + hypothetical protein gene gene-HME7025_02080 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02080 HME7025_02081 HME7025_02081 HME7025_02081 2437289 2437435 - hypothetical protein gene gene-HME7025_02081 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02081 HME7025_02082 HME7025_02082 HME7025_02082 2437582 2437995 + hypothetical protein gene gene-HME7025_02082 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02082 HME7025_02083 HME7025_02083 zntA zntA 2438014 2440047 - Cadmium-exporting ATPase ATP-binding%3B Cell membrane%3B Hydrolase%3B Ion transport%3B Magnesium%3B Membrane%3B Metal-binding%3B Nucleotide-binding%3B Phosphoprotein%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Zinc%3B Zinc transport.%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 1 HMA domain%3B KEGG: wvi:Weevi_0055 Cd2+/Zn2+-exporting ATPase gene gene-HME7025_02083 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02083 HME7025_02084 HME7025_02084 HME7025_02084 2440044 2440247 - hypothetical protein gene gene-HME7025_02084 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02084 HME7025_02085 HME7025_02085 HME7025_02085 2440359 2441600 - Cation efflux system protein CzcB Cadmium resistance%3B Cobalt%3B Plasmid%3B Transport%3B Zinc.%3B CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene-HME7025_02085 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02085 HME7025_02086 HME7025_02086 HME7025_02086 2441602 2445999 - Multidrug resistance protein MdtB Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtB subfamily gene gene-HME7025_02086 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02086 HME7025_02087 HME7025_02087 HME7025_02087 2446664 2447224 - hypothetical protein gene gene-HME7025_02087 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02087 HME7025_02088 HME7025_02088 HME7025_02088 2447289 2449544 - Laccase Apoplast%3B Copper%3B Glycoprotein%3B Lignin degradation%3B Metal-binding%3B Oxidoreductase%3B Repeat%3B Secreted%3B Signal.%3B Lignin degradation and detoxification of lignin-derived products%3B Belongs to the multicopper oxidase family%3B Contains 3 plastocyanin-like domains%3B KEGG: obr:102705117 laccase gene gene-HME7025_02088 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02088 HME7025_02089 HME7025_02089 HME7025_02089 2449547 2450260 - Cu(2+)-exporting ATPase KEGG: gfo:GFO_1184 Cu2+-exporting ATPase gene gene-HME7025_02089 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02089 HME7025_02090 HME7025_02090 HME7025_02090 2450330 2450743 - hypothetical protein gene gene-HME7025_02090 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02090 HME7025_02091 HME7025_02091 HME7025_02091 2450877 2451437 - hypothetical protein gene gene-HME7025_02091 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02091 HME7025_02092 HME7025_02092 HME7025_02092 2451437 2452036 - hypothetical protein gene gene-HME7025_02092 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02092 HME7025_02093 HME7025_02093 HME7025_02093 2452124 2452507 - hypothetical protein gene gene-HME7025_02093 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02093 HME7025_02094 HME7025_02094 HME7025_02094 2453385 2453885 - hypothetical protein gene gene-HME7025_02094 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02094 HME7025_02095 HME7025_02095 HME7025_02095 2453898 2454215 - Transcriptional repressor SdpR Cytoplasm%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation.%3B Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation%3B Contains 1 HTH arsR-type DNA-binding domain gene gene-HME7025_02095 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02095 HME7025_02096 HME7025_02096 HME7025_02096 2454612 2455298 - hypothetical protein gene gene-HME7025_02096 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02096 HME7025_02097 HME7025_02097 HME7025_02097 2456349 2458976 + hypothetical protein gene gene-HME7025_02097 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02097 HME7025_02098 HME7025_02098 HME7025_02098 2459061 2459912 - hypothetical protein gene gene-HME7025_02098 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02098 HME7025_02099 HME7025_02099 algL algL 2460078 2462099 + Mannuronate-specific alginate lyase KEGG: mro:MROS_1361 poly(beta-D-mannuronate) lyase gene gene-HME7025_02099 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02099 HME7025_02100 HME7025_02100 HME7025_02100 2462113 2462604 + hypothetical protein gene gene-HME7025_02100 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02100 HME7025_02101 HME7025_02101 HME7025_02101 2462608 2463897 - Cephalosporin-C deacetylase Carbohydrate metabolism%3B Hydrolase%3B Polysaccharide degradation%3B Serine esterase%3B Signal%3B Xylan degradation.%3B Involved in degradation of plant cell wall polysaccharides. Has acetyl esterase activity towards a broad range of substrates including xylose-tetraacetate%2C 4-O- methylumbelliferyl acetate%2C glucose-pentaacetate%2C cephalosporin C%2C and acetylated xylo-oligosaccharides smaller than xylo-heptaose. Displays no detectable activity on polymeric acetylated xylan%3B Belongs to the carbohydrate esterase 7 family%3B KEGG: mlo:mlr6993 cephalosporin-C deacetylase gene gene-HME7025_02101 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02101 HME7025_02102 HME7025_02102 ape3 ape3 2463955 2465511 - Aminopeptidase Y Carboxypeptidase%3B Endoplasmic reticulum%3B Glycoprotein%3B Golgi apparatus%3B Hydrolase%3B Lysosome%3B Metal-binding%3B Metalloprotease%3B Protease%3B Secreted%3B Signal%3B Zinc%3B Zymogen.%3B Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity)%3B Belongs to the peptidase M28 family%3B KEGG: sen:SACE_5205 aminopeptidase Y gene gene-HME7025_02102 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02102 HME7025_02103 HME7025_02103 HME7025_02103 2465618 2466127 - hypothetical protein gene gene-HME7025_02103 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02103 HME7025_02104 HME7025_02104 HME7025_02104 2466357 2467124 + 3-oxoacyl-[acyl-carrier-protein] reductase Cytoplasm%3B NAD%3B Oxidoreductase.%3B Dehydrogenase that mediates the formation of 2%2C5- dihydroxybenzoic acid (2%2C5-DHBA)%2C a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2%2C thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pae:PA4089 3-oxoacyl-(acyl-carrier protein) reductase gene gene-HME7025_02104 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02104 HME7025_02105 HME7025_02105 HME7025_02105 2467185 2469446 - Ribonucleoside-diphosphate reductase KEGG: vba:IMCC26134_02945 ribonucleoside-diphosphate reductase alpha chain gene gene-HME7025_02105 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02105 HME7025_02106 HME7025_02106 HME7025_02106 2469448 2470407 - putative iron-sulfur cluster repair protein Cytoplasm%3B Iron%3B Metal-binding.%3B Di-iron-containing protein involved in the repair of iron-sulfur clusters%3B Belongs to the RIC family gene gene-HME7025_02106 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02106 HME7025_02107 HME7025_02107 HME7025_02107 2470567 2471004 + hypothetical protein gene gene-HME7025_02107 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02107 HME7025_02108 HME7025_02108 HME7025_02108 2471086 2471448 + hypothetical protein gene gene-HME7025_02108 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02108 HME7025_02109 HME7025_02109 HME7025_02109 2471531 2472877 + hypothetical protein gene gene-HME7025_02109 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02109 HME7025_02110 HME7025_02110 HME7025_02110 2472946 2473788 - hypothetical protein gene gene-HME7025_02110 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02110 HME7025_02111 HME7025_02111 HME7025_02111 2473795 2476539 - hypothetical protein gene gene-HME7025_02111 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02111 HME7025_02112 HME7025_02112 HME7025_02112 2476696 2479029 - hypothetical protein gene gene-HME7025_02112 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02112 HME7025_02113 HME7025_02113 rhmA rhmA 2479078 2479911 - 2-keto-3-deoxy-L-rhamnonate aldolase Lyase%3B Magnesium%3B Metal-binding.%3B Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde%3B Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily%3B KEGG: cama:F384_12025 2-dehydro-3-deoxy-L-rhamnonate aldolase gene gene-HME7025_02113 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02113 HME7025_02114 HME7025_02114 HME7025_02114 2479990 2480664 - SCO1 protein like protein Cell membrane%3B Chaperone%3B Copper%3B Lipoprotein%3B Membrane%3B Metal-binding%3B Palmitate%3B Signal.%3B Neccessary for insertion of copper into the active site of cytochrome c oxidase. May play a role in copper homeostasis or redox signaling%3B Belongs to the SCO1/2 family%3B Contains 1 thioredoxin domain gene gene-HME7025_02114 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02114 HME7025_02115 HME7025_02115 HME7025_02115 2480606 2481187 - hypothetical protein gene gene-HME7025_02115 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02115 HME7025_02116 HME7025_02116 HME7025_02116 2481144 2481890 - hypothetical protein gene gene-HME7025_02116 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02116 HME7025_02117 HME7025_02117 HME7025_02117 2482121 2484487 - hypothetical protein gene gene-HME7025_02117 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02117 HME7025_02118 HME7025_02118 ggcX ggcX 2484522 2485868 - Peptidyl-glutamate 4-carboxylase Acetylation%3B Disulfide bond%3B Endoplasmic reticulum%3B Lyase%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B KEGG: asn:102383382 vitamin K-dependent gamma-carboxylase gene gene-HME7025_02118 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02118 HME7025_02119 HME7025_02119 HME7025_02119 2485855 2486982 - Iron-regulated protein Cell inner membrane%3B Cell membrane%3B Iron%3B Membrane%3B Signal%3B Transmembrane. gene gene-HME7025_02119 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02119 HME7025_02120 HME7025_02120 HME7025_02120 2487043 2488215 - hypothetical protein gene gene-HME7025_02120 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02120 HME7025_02121 HME7025_02121 HME7025_02121 2488918 2492052 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_02121 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02121 HME7025_02122 HME7025_02122 HME7025_02122 2492075 2493925 + hypothetical protein gene gene-HME7025_02122 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02122 HME7025_02123 HME7025_02123 HME7025_02123 2494175 2497342 + hypothetical protein gene gene-HME7025_02123 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02123 HME7025_02124 HME7025_02124 HME7025_02124 2497339 2498637 + hypothetical protein gene gene-HME7025_02124 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02124 HME7025_02125 HME7025_02125 HME7025_02125 2498627 2499496 + hypothetical protein gene gene-HME7025_02125 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02125 HME7025_02126 HME7025_02126 glmS glmS 2499760 2501595 + Glutamine--fructose-6-phosphate transaminase (isomerizing) Aminotransferase%3B Cytoplasm%3B Glutamine amidotransferase%3B Repeat%3B Transferase.%3B Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source%3B Contains 1 glutamine amidotransferase type-2 domain%3B Contains 2 SIS domains%3B KEGG: alv:Alvin_0239 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) gene gene-HME7025_02126 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02126 HME7025_02127 HME7025_02127 HME7025_02127 2501898 2504351 + Glutaminase Glycoprotein%3B Hydrolase%3B Secreted%3B Signal.%3B Glutaminase catalyzes the hydrolysis of glutamine to glutamic acid and plays a key role in nitrogen metabolism. Catalyzes the hydrolysis not only of L-glutamine but also of D- glutamine%3B Belongs to the fungal glutaminase gtaA family gene gene-HME7025_02127 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02127 HME7025_02128 HME7025_02128 HME7025_02128 2504357 2505376 + L-galactonate-5-dehydrogenase Metal-binding%3B NAD%3B Oxidoreductase%3B Zinc.%3B Catalyzes the oxidation of L-galactonate to D- tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro%2C can also use L-gulonate%3B Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: bli:BL03800 null%3B With NAD(+) or NADP(+) as acceptor gene gene-HME7025_02128 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02128 HME7025_02129 HME7025_02129 HME7025_02129 2505423 2506343 + Ribose import ATP-binding protein RbsA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Repeat%3B Sugar transport%3B Transport.%3B Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Ribose importer (TC 3. A. 1. 2. 1) family%3B Contains 2 ABC transporter domains gene gene-HME7025_02129 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02129 HME7025_02130 HME7025_02130 HME7025_02130 2506333 2507175 + uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene-HME7025_02130 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02130 HME7025_02131 HME7025_02131 HME7025_02131 2507175 2507861 + hypothetical protein gene gene-HME7025_02131 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02131 HME7025_02132 HME7025_02132 HME7025_02132 2507866 2508510 + hypothetical protein gene gene-HME7025_02132 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02132 HME7025_02133 HME7025_02133 HME7025_02133 2508488 2508811 + uncharacterized protein gene gene-HME7025_02133 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02133 HME7025_02134 HME7025_02134 HME7025_02134 2508916 2509839 - hypothetical protein gene gene-HME7025_02134 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02134 HME7025_02135 HME7025_02135 HME7025_02135 2510035 2511129 + Beta-1%2C4-mannooligosaccharide phosphorylase KEGG: tme:Tmel_1013 beta-1%2C4-mannooligosaccharide/beta-1%2C4-mannosyl-N-acetylglucosamine phosphorylase gene gene-HME7025_02135 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02135 HME7025_02136 HME7025_02136 HME7025_02136 2511132 2511530 + uncharacterized protein gene gene-HME7025_02136 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02136 HME7025_02137 HME7025_02137 HME7025_02137 2511527 2513683 + uncharacterized protein gene gene-HME7025_02137 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02137 HME7025_02138 HME7025_02138 HME7025_02138 2514069 2515724 - Glutamate carboxypeptidase II Alternative splicing%3B Carboxypeptidase%3B Dipeptidase%3B Glycoprotein%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Multifunctional enzyme%3B Polymorphism%3B Protease%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix%3B Zinc.%3B Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N- acetylaspartylglutamate%3B Belongs to the peptidase M28 family. M28B subfamily%3B KEGG: gau:GAU_0163 N-acetylated-alpha-linked acidic dipeptidase gene gene-HME7025_02138 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02138 HME7025_02139 HME7025_02139 gldC gldC 2515775 2518657 + Glycine dehydrogenase (aminomethyl-transferring) Oxidoreductase%3B Pyridoxal phosphate.%3B The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofacto%3B CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein%3B Belongs to the GcvP family%3B KEGG: orh:Ornrh_1306 glycine dehydrogenase gene gene-HME7025_02139 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02139 HME7025_02140 HME7025_02140 fadN fadN 2518816 2521221 + 3-hydroxyacyl-CoA dehydrogenase Fatty acid metabolism%3B Lipid degradation%3B Lipid metabolism%3B NAD%3B Oxidoreductase.%3B Involved in the degradation of long-chain fatty acids. Belongs to the 3-hydroxyacyl-CoA dehydrogenase family%3B KEGG: nso:NIASO_11550 3-hydroxyacyl-CoA dehydrogenase gene gene-HME7025_02140 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02140 HME7025_02141 HME7025_02141 fadA fadA 2521243 2522418 + Acetyl-CoA C-acyltransferase Acyltransferase%3B Cytoplasm%3B Fatty acid metabolism%3B Lipid degradation%3B Lipid metabolism%3B Transferase.%3B Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed%3B Belongs to the thiolase family%3B KEGG: nko:Niako_5586 acetyl-CoA acyltransferase gene gene-HME7025_02141 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02141 HME7025_02142 HME7025_02142 HME7025_02142 2522690 2523913 + Acetylornithine transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Arginine biosynthesis%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase.%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily%3B KEGG: pca:Pcar_2414 acetylornithine aminotransferase gene gene-HME7025_02142 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02142 HME7025_02143 HME7025_02143 dopA dopA 2523917 2524744 - 4%2C5-DOPA dioxygenase extradiol Cytoplasm%3B Dioxygenase%3B Metal-binding%3B Oxidoreductase%3B Zinc.%3B Opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5%2C thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. Produces mainly (S)-betalamic acid%3B Belongs to the DODA-type extradiol aromatic ring- opening dioxygenase family%3B KEGG: pop:POPTR_0004s14280g 4%2C5-DOPA dioxygenase extradiol%3B With incorporation of two atoms of oxygen gene gene-HME7025_02143 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02143 HME7025_02144 HME7025_02144 HME7025_02144 2524746 2526263 - Transcription termination factor Rho ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B RNA-binding%3B Transcription%3B Transcription regulation%3B Transcription termination.%3B Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA%2C activation of Rho's RNA-dependent ATPase activity%2C and release of the mRNA from the DNA template%3B Belongs to the Rho family gene gene-HME7025_02144 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02144 HME7025_02145 HME7025_02145 HME7025_02145 2526573 2527715 + 8-amino-7-oxononanoate synthase Acyltransferase%3B Biotin biosynthesis%3B Pyridoxal phosphate%3B Transferase.%3B Catalyzes the decarboxylative condensation of pimeloyl- [acyl-carrier protein] and L-alanine to produce 8-amino-7- oxononanoate (AON)%2C [acyl-carrier protein]%2C and carbon dioxide%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily%3B KEGG: srd:SD10_26815 8-amino-7-oxononanoate synthase gene gene-HME7025_02145 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02145 HME7025_02146 HME7025_02146 bioD bioD 2527712 2528323 + Dethiobiotin synthase ATP-binding%3B Biotin biosynthesis%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding.%3B Catalyzes a mechanistically unusual reaction%2C the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7%2C8-diaminopelargonic acid (DAPA) to form an ureido ring%3B Belongs to the dethiobiotin synthetase family%3B KEGG: cpn:CPn1042 dethiobiotin synthetase gene gene-HME7025_02146 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02146 HME7025_02147 HME7025_02147 bioA bioA 2528301 2529608 + Adenosylmethionine--8-amino-7-oxononanoate transaminase Aminotransferase%3B Biotin biosynthesis%3B Cytoplasm%3B Pyridoxal phosphate%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7%2C8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily%3B KEGG: phe:Phep_2566 adenosylmethionine---8-amino-7-oxononanoate aminotransferase gene gene-HME7025_02147 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02147 HME7025_02148 HME7025_02148 HME7025_02148 2529598 2530065 - hypothetical protein gene gene-HME7025_02148 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02148 HME7025_02149 HME7025_02149 betA betA 2530073 2531683 - Choline dehydrogenase FAD%3B Flavoprotein%3B NAD%3B Oxidoreductase.%3B Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate%3B Belongs to the GMC oxidoreductase family%3B KEGG: pae:PA3710 choline dehydrogenase gene gene-HME7025_02149 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02149 HME7025_02150 HME7025_02150 HME7025_02150 2531750 2532331 + hypothetical protein gene gene-HME7025_02150 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02150 HME7025_02151 HME7025_02151 nrdB nrdB 2532383 2533348 - Ribonucleoside-diphosphate reductase DNA replication%3B Iron%3B Metal-binding%3B Oxidoreductase.%3B Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)%3B Belongs to the ribonucleoside diphosphate reductase small chain family%3B KEGG: pcu:pc1349 ribonucleoside-diphosphate reductase beta chain gene gene-HME7025_02151 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02151 HME7025_02152 HME7025_02152 HME7025_02152 2533510 2534115 - hypothetical protein gene gene-HME7025_02152 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02152 HME7025_02153 HME7025_02153 HME7025_02153 2534202 2537057 + UvrABC system protein ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA excision%3B DNA repair%3B DNA-binding%3B Excision nuclease%3B Metal-binding%3B Nucleotide-binding%3B Repeat%3B SOS response%3B Transport%3B Zinc%3B Zinc-finger.%3B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Belongs to the ABC transporter superfamily. UvrA family%3B Contains 2 ABC transporter domains gene gene-HME7025_02153 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02153 HME7025_02154 HME7025_02154 nuoN nuoN 2537067 2538548 + NADH:ubiquinone reductase (H(+)-translocating) Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 2 family%3B KEGG: hpy:HP1273 NADH-quinone oxidoreductase subunit N gene gene-HME7025_02154 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02154 HME7025_02155 HME7025_02155 HME7025_02155 2538645 2540561 + Amidophosphoribosyltransferase KEGG: psn:Pedsa_1942 amidophosphoribosyltransferase gene gene-HME7025_02155 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02155 HME7025_02156 HME7025_02156 HME7025_02156 2540695 2543544 - hypothetical protein gene gene-HME7025_02156 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02156 HME7025_02157 HME7025_02157 HME7025_02157 2543609 2544694 + hypothetical protein gene gene-HME7025_02157 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02157 HME7025_02158 HME7025_02158 HME7025_02158 2544791 2547334 + hypothetical protein gene gene-HME7025_02158 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02158 HME7025_02159 HME7025_02159 HME7025_02159 2547344 2548438 + hypothetical protein gene gene-HME7025_02159 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02159 HME7025_02160 HME7025_02160 HME7025_02160 2548512 2551316 - Translation initiation factor IF-2 Cytoplasm%3B GTP-binding%3B Initiation factor%3B Nucleotide-binding%3B Protein biosynthesis.%3B One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene-HME7025_02160 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02160 HME7025_02161 HME7025_02161 HME7025_02161 2551358 2552605 - Transcription termination/antitermination protein NusA Cytoplasm%3B RNA-binding%3B Transcription%3B Transcription antitermination%3B Transcription regulation%3B Transcription termination.%3B Participates in both transcription termination and antitermination%3B Belongs to the NusA family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain gene gene-HME7025_02161 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02161 HME7025_02162 HME7025_02162 HME7025_02162 2552622 2553098 - Ribosome maturation factor RimP Cytoplasm%3B Ribosome biogenesis.%3B Required for maturation of 30S ribosomal subunits%3B Belongs to the RimP family gene gene-HME7025_02162 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02162 HME7025_02163 HME7025_02163 fabI fabI 2553306 2554121 + Enoyl-[acyl-carrier-protein] reductase (NADH) KEGG: bfr:BF0972 enoyl-(acyl-carrier protein) reductase I gene gene-HME7025_02163 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02163 HME7025_02164 HME7025_02164 HME7025_02164 2554185 2554697 + hypothetical protein gene gene-HME7025_02164 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02164 HME7025_02165 HME7025_02165 HME7025_02165 2554919 2556877 - Colicin I receptor Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB. Belongs to the TonB-dependent receptor family gene gene-HME7025_02165 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02165 HME7025_02166 HME7025_02166 HME7025_02166 2557268 2557834 + DNA-3-methyladenine glycosylase I DNA damage%3B DNA repair%3B Hydrolase%3B Metal-binding%3B Zinc.%3B KEGG: plu:plu0292 DNA-3-methyladenine glycosylase I gene gene-HME7025_02166 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02166 HME7025_02167 HME7025_02167 HME7025_02167 2557839 2558570 + Dolichyl-phosphate beta-D-mannosyltransferase Cytoplasm%3B Glycosyltransferase%3B Transferase.%3B Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM%3B catalytic activity in vitro is enhanced by Lnt (AC A0QZ13) (PubMed:12427759). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2%2C eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity)%3B Belongs to the glycosyltransferase 2 family%3B KEGG: osp:Odosp_2177 dolichol-phosphate mannosyltransferase gene gene-HME7025_02167 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02167 HME7025_02168 HME7025_02168 HME7025_02168 2558567 2559109 + UPF0093 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0093 family gene gene-HME7025_02168 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02168 HME7025_02169 HME7025_02169 HME7025_02169 2559106 2559567 - SsrA-binding protein Cytoplasm%3B RNA-binding.%3B Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA)%2C required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape%2C replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gen%3B the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide'%2C a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA%2C entering the A-site of stalled ribosomes%2C displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRN%3B the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation%2C which seems to be the essential function of trans- translation%3B Belongs to the SmpB family gene gene-HME7025_02169 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02169 HME7025_02170 HME7025_02170 HME7025_02170 2559627 2560208 - hypothetical protein gene gene-HME7025_02170 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02170 HME7025_02171 HME7025_02171 HME7025_02171 2560284 2560652 - hypothetical protein gene gene-HME7025_02171 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02171 HME7025_02172 HME7025_02172 HME7025_02172 2560655 2563093 - Penicillin amidase Antibiotic resistance%3B Calcium%3B Hydrolase%3B Metal-binding%3B Secreted%3B Signal%3B Zymogen.%3B Belongs to the peptidase S45 family%3B KEGG: hyd:PK28_03010 penicillin amidase gene gene-HME7025_02172 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02172 HME7025_02173 HME7025_02173 HME7025_02173 2563226 2564170 + Beta-aspartyl-peptidase Autocatalytic cleavage%3B Hydrolase%3B Periplasm%3B Protease%3B Signal.%3B Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. Requires that the glycosylated asparagine moiety is not substituted on its N- (R1) and C- (R2) terminus. Belongs to the Ntn-hydrolase family%3B KEGG: cap:CLDAP_39180 beta-aspartyl-peptidase (threonine type) gene gene-HME7025_02173 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02173 HME7025_02174 HME7025_02174 HME7025_02174 2564183 2566015 + Glycogen(starch) synthase Allosteric enzyme%3B Glycogen biosynthesis%3B Glycosyltransferase%3B Phosphoprotein%3B Transferase.%3B Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1%2C4-glucan%3B Belongs to the glycosyltransferase 3 family%3B KEGG: bfo:BRAFLDRAFT_119087 glycogen(starch) synthase gene gene-HME7025_02174 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02174 HME7025_02175 HME7025_02175 HME7025_02175 2566076 2566735 - hypothetical protein gene gene-HME7025_02175 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02175 HME7025_02176 HME7025_02176 HME7025_02176 2566732 2569437 - hypothetical protein gene gene-HME7025_02176 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02176 HME7025_02177 HME7025_02177 xylA xylA 2569442 2570770 - Xylose isomerase Carbohydrate metabolism%3B Isomerase%3B Magnesium%3B Manganese%3B Metal-binding%3B Pentose shunt%3B Xylose metabolism.%3B Belongs to the xylose isomerase family%3B KEGG: sde:Sde_2504 xylose isomerase gene gene-HME7025_02177 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02177 HME7025_02178 HME7025_02178 HME7025_02178 2570946 2573303 + Membrane alanyl aminopeptidase KEGG: chu:CHU_1442 aminopeptidase N gene gene-HME7025_02178 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02178 HME7025_02179 HME7025_02179 crtB crtB 2573380 2574210 - 15-cis-phytoene synthase KEGG: nmo:Nmlp_3029 phytoene synthase gene gene-HME7025_02179 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02179 HME7025_02180 HME7025_02180 crtP crtP 2574212 2575696 - Diapolycopene oxygenase Carotenoid biosynthesis%3B Membrane%3B NAD%3B Oxidoreductase%3B Signal%3B Transmembrane%3B Transmembrane helix.%3B Phytoene desaturase involved in the carotenoid biosynthesis pathway. Converts phytoene into 3%2C4-didehydrolycopene via the intermediary of phytofluene%2C zeta-carotene%2C neurosporene and lycopene%2C by introducing up to five double bonds into phytoene (By similarity)%3B Belongs to the carotenoid/retinoid oxidoreductase family%3B KEGG: ble:BleG1_3942 diapolycopene oxygenase gene gene-HME7025_02180 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02180 HME7025_02181 HME7025_02181 HME7025_02181 2575824 2576327 - ECF RNA polymerase sigma factor EcfG DNA-binding%3B Sigma factor%3B Stress response%3B Transcription%3B Transcription regulation.%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity). Regulates expression of hpnP under a variety of stresses%2C including high temperature%2C pH stress%2C and presence of nonionic osmolytes (PubMed:23524612)%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene-HME7025_02181 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02181 HME7025_02182 HME7025_02182 HME7025_02182 2576522 2578855 + hypothetical protein gene gene-HME7025_02182 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02182 HME7025_02183 HME7025_02183 HME7025_02183 2578856 2580262 - hypothetical protein gene gene-HME7025_02183 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02183 HME7025_02184 HME7025_02184 HME7025_02184 2580274 2581119 - hypothetical protein gene gene-HME7025_02184 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02184 HME7025_02185 HME7025_02185 HME7025_02185 2581148 2582866 - hypothetical protein gene gene-HME7025_02185 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02185 HME7025_02186 HME7025_02186 HME7025_02186 2582971 2584083 + hypothetical protein gene gene-HME7025_02186 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02186 HME7025_02187 HME7025_02187 HME7025_02187 2584084 2585166 - hypothetical protein gene gene-HME7025_02187 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02187 HME7025_02188 HME7025_02188 HME7025_02188 2585168 2586574 - putative alginate O-acetylase AlgI Acyltransferase%3B Alginate biosynthesis%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Together with AlgJ and AlgF%2C forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate increases cyst resistance to desiccation. Belongs to the membrane-bound acyltransferase family gene gene-HME7025_02188 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02188 HME7025_02189 HME7025_02189 iarS iarS 2586581 2589982 - Isoleucine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Zinc.%3B Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine%2C to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)%3B Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily%3B KEGG: scn:Solca_3313 isoleucyl-tRNA synthetase gene gene-HME7025_02189 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02189 HME7025_02190 HME7025_02190 HME7025_02190 2590157 2590738 + 5-formyltetrahydrofolate cyclo-ligase ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding.%3B Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5%2C10-methenyltetrahydrofolate (By similarity)%3B Belongs to the 5-formyltetrahydrofolate cyclo-ligase family%3B KEGG: bha:BH1417 5-formyltetrahydrofolate cyclo-ligase gene gene-HME7025_02190 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02190 HME7025_02191 HME7025_02191 HME7025_02191 2590847 2591314 + hypothetical protein gene gene-HME7025_02191 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02191 HME7025_02192 HME7025_02192 HME7025_02192 2591325 2592317 + Aspartate-semialdehyde dehydrogenase Amino-acid biosynthesis%3B Diaminopimelate biosynthesis%3B Lysine biosynthesis%3B Methionine biosynthesis%3B NADP%3B Oxidoreductase%3B Phosphoprotein%3B Threonine biosynthesis.%3B Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate%3B Belongs to the aspartate-semialdehyde dehydrogenase family%3B KEGG: lpn:lpg2302 aspartate-semialdehyde dehydrogenase gene gene-HME7025_02192 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02192 HME7025_02193 HME7025_02193 pdxJ pdxJ 2592352 2593068 + Pyridoxine 5'-phosphate synthase Cytoplasm%3B Pyridoxine biosynthesis%3B Transferase.%3B Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate%3B Belongs to the PNP synthase family%3B KEGG: xal:XALc_0013 pyridoxine 5-phosphate synthase gene gene-HME7025_02193 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02193 HME7025_02194 HME7025_02194 HME7025_02194 2593439 2594053 - hypothetical protein gene gene-HME7025_02194 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02194 HME7025_02195 HME7025_02195 HME7025_02195 2594282 2594881 + hypothetical protein gene gene-HME7025_02195 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02195 HME7025_02196 HME7025_02196 HME7025_02196 2594850 2595068 + hypothetical protein gene gene-HME7025_02196 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02196 HME7025_02197 HME7025_02197 HME7025_02197 2595122 2595772 + DNA-(apurinic or apyrimidinic site) lyase 4Fe-4S%3B DNA damage%3B DNA repair%3B DNA-binding%3B Glycosidase%3B Hydrolase%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding.%3B DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond%2C leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination%2C leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate%3B Belongs to the Nth/MutY family%3B Contains 1 HhH domain%3B KEGG: str:Sterm_3667 endonuclease III gene gene-HME7025_02197 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02197 HME7025_02198 HME7025_02198 HME7025_02198 2595769 2596341 + Nicotinamide riboside transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Required for nicotinamide riboside transport across the inner membrane%3B Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4. B. 1) family gene gene-HME7025_02198 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02198 HME7025_02199 HME7025_02199 HME7025_02199 2596498 2596881 + hypothetical protein gene gene-HME7025_02199 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02199 HME7025_02200 HME7025_02200 HME7025_02200 2596882 2597232 + hypothetical protein gene gene-HME7025_02200 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02200 HME7025_02201 HME7025_02201 HME7025_02201 2597229 2597570 + hypothetical protein gene gene-HME7025_02201 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02201 HME7025_02202 HME7025_02202 HME7025_02202 2597684 2598676 - Peptide chain release factor Cytoplasm%3B Methylation%3B Protein biosynthesis.%3B Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene-HME7025_02202 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02202 HME7025_02203 HME7025_02203 pdhD pdhD 2598839 2600233 + Dihydrolipoyl dehydrogenase Cytoplasm%3B Disulfide bond%3B FAD%3B Flavoprotein%3B Glycolysis%3B NAD%3B Oxidoreductase%3B Redox-active center.%3B The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1)%2C lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: kpk:A593_15720 dihydrolipoamide dehydrogenase gene gene-HME7025_02203 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02203 HME7025_02204 HME7025_02204 HME7025_02204 2600228 2600860 - hypothetical protein gene gene-HME7025_02204 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02204 HME7025_02205 HME7025_02205 HME7025_02205 2600864 2602186 - Inositol 2-dehydrogenase NAD%3B Oxidoreductase.%3B Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI)%2C respectively%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: btra:F544_22970 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_02205 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02205 HME7025_02206 HME7025_02206 HME7025_02206 2602268 2605384 - Cation efflux system protein CzcA Cadmium resistance%3B Cell membrane%3B Cobalt%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Zinc.%3B Has a low cation transport activity for cobalt%2C it is essential for the expression of cobalt%2C zinc%2C and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC). Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene-HME7025_02206 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02206 HME7025_02207 HME7025_02207 HME7025_02207 2605397 2606653 - hypothetical protein gene gene-HME7025_02207 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02207 HME7025_02208 HME7025_02208 HME7025_02208 2606671 2607753 - Cobalt-zinc-cadmium resistance protein CzcB Cadmium resistance%3B Cell inner membrane%3B Cell membrane%3B Cobalt%3B Coiled coil%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Zinc.%3B CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene-HME7025_02208 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02208 HME7025_02209 HME7025_02209 HME7025_02209 2607756 2609012 - hypothetical protein gene gene-HME7025_02209 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02209 HME7025_02210 HME7025_02210 arlS arlS 2609112 2610479 - Histidine kinase ATP-binding%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Virulence.%3B Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion%2C autolysis%2C multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: swa:A284_06565 two-component system%2C OmpR family%2C sensor histidine kinase ArlS gene gene-HME7025_02210 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02210 HME7025_02211 HME7025_02211 HME7025_02211 2610469 2611170 - Transcriptional regulatory protein TcrA Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system.%3B Member of the three-protein two-component system HK1/HK2/TcrA%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene-HME7025_02211 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02211 HME7025_02212 HME7025_02212 HME7025_02212 2611208 2611813 - Protease synthase and sporulation protein PAI Sporulation.%3B Involved in the reduction of extracellular and cell- associated protease levels%2C as well as in the reduced levels of alpha-amylase%2C levansucrase%2C alkaline phosphatase and sporulation inhibition%2C when present in high copy number. Belongs to the PaiB family gene gene-HME7025_02212 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02212 HME7025_02213 HME7025_02213 HME7025_02213 2611915 2612002 - tRNA-Ser tRNA gene-HME7025_02213 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02213 HME7025_02214 HME7025_02214 HME7025_02214 2612325 2614415 + Assimilatory sulfite reductase (ferredoxin) 4Fe-4S%3B Electron transport%3B Heme%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Nitrate assimilation%3B Oxidoreductase%3B Transport.%3B Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B KEGG: cpi:Cpin_6617 sulfite reductase (ferredoxin) gene gene-HME7025_02214 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02214 HME7025_02215 HME7025_02215 HME7025_02215 2614417 2615214 + Uroporphyrinogen-III C-methyltransferase Cobalamin biosynthesis%3B Lyase%3B Methyltransferase%3B Multifunctional enzyme%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Porphyrin biosynthesis%3B S-adenosyl-L-methionine%3B Transferase.%3B Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: cbal:M667_04590 uroporphyrin-III C-methyltransferase gene gene-HME7025_02215 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02215 HME7025_02216 HME7025_02216 HME7025_02216 2615204 2615593 + 2-iminobutanoate/2-iminopropanoate deaminase KEGG: opr:Ocepr_0503 2-iminobutanoate/2-iminopropanoate deaminase gene gene-HME7025_02216 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02216 HME7025_02217 HME7025_02217 HME7025_02217 2615687 2616670 - D-glycero-beta-D-manno-heptose-7-phosphate kinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1%2C7-bisphosphate%3B Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate%2C yielding ADP-D-glycero-beta-D-manno- heptose%3B In the N-terminal sectio%3B belongs to the carbohydrate kinase PfkB family%3B In the C-terminal sectio%3B belongs to the cytidylyltransferase family%3B KEGG: ssz:SCc_595 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase gene gene-HME7025_02217 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02217 HME7025_02218 HME7025_02218 moaA moaA 2616673 2617569 - Cyclic pyranopterin phosphate synthase 4Fe-4S%3B GTP-binding%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B S-adenosyl-L-methionine.%3B Catalyzes%2C together with MoaC%2C the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)%3B Belongs to the radical SAM superfamily. MoaA family%3B KEGG: tli:Tlie_0988 cyclic pyranopterin phosphate synthase gene gene-HME7025_02218 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02218 HME7025_02219 HME7025_02219 HME7025_02219 2617620 2617979 + hypothetical protein gene gene-HME7025_02219 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02219 HME7025_02220 HME7025_02220 HME7025_02220 2618024 2619916 + NADH:ubiquinone reductase (H(+)-translocating) Chloroplast%3B Membrane%3B NAD%3B NADP%3B Oxidoreductase%3B Plastid%3B Plastoquinone%3B Quinone%3B Thylakoid%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B NDH shuttles electrons from NAD(P)H:plastoquinone%2C via FMN and iron-sulfur (Fe-S) centers%2C to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I subunit 5 family%3B KEGG: bge:BC1002_0967 NADH-quinone oxidoreductase subunit L gene gene-HME7025_02220 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02220 HME7025_02221 HME7025_02221 nuoM nuoM 2619939 2621597 + NADH:ubiquinone reductase (H(+)-translocating) Membrane%3B NAD%3B NADP%3B Oxidoreductase%3B Plastoquinone%3B Quinone%3B Thylakoid%3B Transmembrane%3B Transmembrane helix.%3B NDH-1 shuttles electrons from NAD(P)H%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 4 family%3B KEGG: eol:Emtol_3460 NADH-quinone oxidoreductase subunit M gene gene-HME7025_02221 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02221 HME7025_02222 HME7025_02222 HME7025_02222 2621608 2621967 + hypothetical protein gene gene-HME7025_02222 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02222 HME7025_02223 HME7025_02223 HME7025_02223 2621996 2622892 + Hydroxypyruvate isomerase Isomerase.%3B Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)%3B Belongs to the hyi family%3B KEGG: gps:C427_3054 hydroxypyruvate isomerase gene gene-HME7025_02223 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02223 HME7025_02224 HME7025_02224 HME7025_02224 2623048 2626278 + hypothetical protein gene gene-HME7025_02224 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02224 HME7025_02225 HME7025_02225 HME7025_02225 2626374 2627147 - Very-long-chain 3-oxoacyl-CoA reductase-like protein Endoplasmic reticulum%3B Membrane%3B NADP%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix.%3B Probable reductase%2C but unlike KCR1%2C has no beta- ketoacyl-coenzyme A reductase activity%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family gene gene-HME7025_02225 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02225 HME7025_02226 HME7025_02226 HME7025_02226 2627214 2628908 - Tetratricopeptide repeat protein Coiled coil%3B Ion transport%3B Phosphoprotein%3B Potassium%3B Potassium transport%3B Repeat%3B TPR repeat%3B Transport.%3B Involved in promoting potassiumm ion uptake%3B Contains 12 TPR repeats gene gene-HME7025_02226 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02226 HME7025_02227 HME7025_02227 HME7025_02227 2629069 2630049 - hypothetical protein gene gene-HME7025_02227 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02227 HME7025_02228 HME7025_02228 HME7025_02228 2630003 2630245 - hypothetical protein gene gene-HME7025_02228 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02228 HME7025_02229 HME7025_02229 HME7025_02229 2630327 2631148 - hypothetical protein gene gene-HME7025_02229 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02229 HME7025_02230 HME7025_02230 HME7025_02230 2631193 2631708 - hypothetical protein gene gene-HME7025_02230 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02230 HME7025_02231 HME7025_02231 HME7025_02231 2631733 2632338 - hypothetical protein gene gene-HME7025_02231 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02231 HME7025_02232 HME7025_02232 HME7025_02232 2632412 2633248 - Biopolymer transport protein ExbB Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene-HME7025_02232 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02232 HME7025_02233 HME7025_02233 HME7025_02233 2633603 2633932 + hypothetical protein gene gene-HME7025_02233 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02233 HME7025_02234 HME7025_02234 HME7025_02234 2633910 2635079 - hypothetical protein gene gene-HME7025_02234 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02234 HME7025_02235 HME7025_02235 HME7025_02235 2635069 2635863 - hypothetical protein gene gene-HME7025_02235 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02235 HME7025_02236 HME7025_02236 HME7025_02236 2635860 2636570 - Dolichyl-phosphate beta-D-mannosyltransferase KEGG: pan:PODANSg446 dolichol-phosphate mannosyltransferase gene gene-HME7025_02236 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02236 HME7025_02237 HME7025_02237 ldcA ldcA 2636691 2637587 + Muramoyltetrapeptide carboxypeptidase Carboxypeptidase%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Hydrolase%3B Peptidoglycan synthesis%3B Protease%3B Serine protease.%3B Releases the terminal D-alanine residue from the cytoplasmic disaccharide-tetrapeptide GlcNAc-MurNAc-L-Ala-gamma-D- Glu-meso-Dap-D-Ala%2C which is a murein turnover product. Probably also act on free tetrapetide. May be involved in murein recycling. Belongs to the peptidase S66 family%3B KEGG: ara:Arad_3308 muramoyltetrapeptide carboxypeptidase gene gene-HME7025_02237 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02237 HME7025_02238 HME7025_02238 HME7025_02238 2637628 2639166 + uncharacterized protein Belongs to the Mg-chelatase subunits D/I family. ComM subfamily gene gene-HME7025_02238 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02238 HME7025_02239 HME7025_02239 HME7025_02239 2639193 2640206 + hypothetical protein gene gene-HME7025_02239 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02239 HME7025_02240 HME7025_02240 HME7025_02240 2640306 2641796 + Bacterial leucyl aminopeptidase Carboxypeptidase%3B Endoplasmic reticulum%3B Glycoprotein%3B Golgi apparatus%3B Hydrolase%3B Lysosome%3B Metal-binding%3B Metalloprotease%3B Protease%3B Secreted%3B Signal%3B Zinc%3B Zymogen.%3B Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity)%3B Belongs to the peptidase M28 family%3B KEGG: acan:ACA1_264610 bacterial leucyl aminopeptidase gene gene-HME7025_02240 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02240 HME7025_02241 HME7025_02241 HME7025_02241 2641856 2643142 + Cell division protein FtsZ Cell cycle%3B Cell division%3B Cytoplasm%3B GTP-binding%3B Nucleotide-binding%3B Septation.%3B Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity%3B Belongs to the FtsZ family gene gene-HME7025_02241 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02241 HME7025_02242 HME7025_02242 HME7025_02242 2643139 2643897 - Copper homeostasis protein CutC Copper%3B Cytoplasm.%3B Involved in copper homeostasis%3B Belongs to the CutC family gene gene-HME7025_02242 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02242 HME7025_02243 HME7025_02243 HME7025_02243 2644078 2644299 + hypothetical protein gene gene-HME7025_02243 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02243 HME7025_02244 HME7025_02244 glpA glpA 2644296 2645879 - Glycerol-3-phosphate dehydrogenase Cytoplasm%3B FAD%3B Flavoprotein%3B Glycerol metabolism%3B Oxidoreductase.%3B Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: aje:HCAG_01207 glycerol-3-phosphate dehydrogenase gene gene-HME7025_02244 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02244 HME7025_02245 HME7025_02245 HME7025_02245 2646069 2646746 + hypothetical protein gene gene-HME7025_02245 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02245 HME7025_02246 HME7025_02246 ribH ribH 2646819 2647295 + 6%2C7-dimethyl-8-ribityllumazine synthase Riboflavin biosynthesis%3B Transferase.%3B Catalyzes the formation of 6%2C7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3%2C4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin%3B Belongs to the DMRL synthase family%3B KEGG: phe:Phep_0527 6%2C7-dimethyl-8-ribityllumazine synthase gene gene-HME7025_02246 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02246 HME7025_02247 HME7025_02247 lysC lysC 2647314 2648636 + Aspartate kinase Alternative initiation%3B Amino-acid biosynthesis%3B ATP-binding%3B Diaminopimelate biosynthesis%3B Kinase%3B Lysine biosynthesis%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate%2C which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine%2C isoleucine and methionine%3B Belongs to the aspartokinase family%3B Contains 1 ACT domain%3B KEGG: dfe:Dfer_3817 aspartate kinase gene gene-HME7025_02247 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02247 HME7025_02248 HME7025_02248 sarS sarS 2648646 2649917 + Serine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine%2C to form the misacylated tRNA L-seryl-tRNA(Sec)%2C which will be further converted into selenocysteinyl-tRNA(Sec)%3B Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily%3B KEGG: ped:ING2D1G_1392 seryl-tRNA synthetase gene gene-HME7025_02248 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02248 HME7025_02249 HME7025_02249 HME7025_02249 2649910 2650617 - Transcriptional regulatory protein AfsQ1 Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system.%3B Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene-HME7025_02249 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02249 HME7025_02250 HME7025_02250 HME7025_02250 2650629 2652488 - Histidine kinase ATP-binding%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system.%3B Member of the two-component regulatory system RprX/RprY. May activate RprY by phosphorylation. Contains 1 histidine kinase domain%3B KEGG: dfe:Dfer_4094 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR gene gene-HME7025_02250 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02250 HME7025_02251 HME7025_02251 HME7025_02251 2652662 2653465 + hypothetical protein gene gene-HME7025_02251 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02251 HME7025_02252 HME7025_02252 ruvB ruvB 2653723 2654748 - DNA helicase ATP-binding%3B DNA damage%3B DNA recombination%3B DNA repair%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B SOS response.%3B RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing%3B Belongs to the RuvB family%3B KEGG: cmr:Cycma_2104 holliday junction DNA helicase RuvB gene gene-HME7025_02252 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02252 HME7025_02253 HME7025_02253 HME7025_02253 2654912 2655613 + Glycerol uptake facilitator protein Cell membrane%3B Glycerol metabolism%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity)%3B Belongs to the MIP/aquaporin (TC 1. A. 8) family gene gene-HME7025_02253 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02253 HME7025_02254 HME7025_02254 glpK glpK 2655623 2657113 + Glycerol kinase Alternative splicing%3B ATP-binding%3B Cytoplasm%3B Glycerol metabolism%3B Kinase%3B Nucleotide-binding%3B Plant defense%3B Transferase.%3B Key enzyme in the regulation of glycerol uptake and metabolism. Required for resistance to nonhost Pseudomonas bacteria and to the pathogenic fungus B. cinerea%3B Belongs to the FGGY kinase family%3B KEGG: tcc:TCM_027288 glycerol kinase gene gene-HME7025_02254 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02254 HME7025_02255 HME7025_02255 HME7025_02255 2657110 2657232 - hypothetical protein gene gene-HME7025_02255 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02255 HME7025_02256 HME7025_02256 speA speA 2657243 2658724 - Arginine decarboxylase KEGG: lby:Lbys_0626 arginine decarboxylase gene gene-HME7025_02256 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02256 HME7025_02257 HME7025_02257 HME7025_02257 2658794 2660197 + UDP-N-acetylmuramate--L-alanine ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Peptidoglycan synthesis.%3B Cell wall formation%3B Belongs to the MurCDEF family%3B KEGG: cpi:Cpin_2341 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase%3B Acid--amino-acid ligases (peptide synthases) gene gene-HME7025_02257 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02257 HME7025_02258 HME7025_02258 HME7025_02258 2660183 2661457 - hypothetical protein gene gene-HME7025_02258 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02258 HME7025_02259 HME7025_02259 HME7025_02259 2661677 2663344 + Sulfate-transporting ATPase ATP-binding%3B Cytoplasm%3B Nucleotide-binding%3B Protein biosynthesis%3B Repeat%3B RNA-binding%3B rRNA-binding%3B Translation regulation%3B tRNA-binding.%3B A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains%3B KEGG: afe:Lferr_0037 sulfate-transporting ATPase gene gene-HME7025_02259 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02259 HME7025_02260 HME7025_02260 HME7025_02260 2663344 2663715 + hypothetical protein gene gene-HME7025_02260 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02260 HME7025_02261 HME7025_02261 HME7025_02261 2663746 2664705 + uncharacterized protein ATP-binding%3B Nucleotide-binding.%3B Belongs to the MoxR family%3B KEGG: ead:OV14_a0309 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene-HME7025_02261 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02261 HME7025_02262 HME7025_02262 HME7025_02262 2664747 2666972 + Rhamnogalacturonan acetylesterase RhgT Hydrolase.%3B May play a role in the degradation of type I rhamnogalacturonan derived from plant cell walls. This enzyme has a broad substrate specificity%2C and shows strong preference for glucose pentaacetate%2C beta-naphthylacetate%2C and p-nitrophenyl acetate (pNPA). Also active toward acetylated xylan%3B Belongs to the 'GDSL' lipolytic enzyme family gene gene-HME7025_02262 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02262 HME7025_02263 HME7025_02263 HME7025_02263 2666983 2667441 + hypothetical protein gene gene-HME7025_02263 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02263 HME7025_02264 HME7025_02264 HME7025_02264 2667442 2667879 - hypothetical protein gene gene-HME7025_02264 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02264 HME7025_02265 HME7025_02265 HME7025_02265 2668326 2669087 + hypothetical protein gene gene-HME7025_02265 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02265 HME7025_02266 HME7025_02266 HME7025_02266 2669087 2672410 + hypothetical protein gene gene-HME7025_02266 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02266 HME7025_02267 HME7025_02267 HME7025_02267 2672489 2674099 + hypothetical protein gene gene-HME7025_02267 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02267 HME7025_02268 HME7025_02268 gpsA gpsA 2674138 2675163 + Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Cytoplasm%3B Lipid biosynthesis%3B Lipid metabolism%3B NAD%3B Oxidoreductase%3B Phospholipid biosynthesis%3B Phospholipid metabolism.%3B Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: coc:Coch_0393 glycerol-3-phosphate dehydrogenase (NAD(P)+) gene gene-HME7025_02268 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02268 HME7025_02269 HME7025_02269 HME7025_02269 2675164 2675556 - putative HIT-like protein Contains 1 HIT domain gene gene-HME7025_02269 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02269 HME7025_02270 HME7025_02270 HME7025_02270 2675558 2677519 - putative potassium transport system protein kup Cell membrane%3B Ion transport%3B Membrane%3B Potassium%3B Potassium transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Transport of potassium into the cell%3B Belongs to the HAK/KUP transporter (TC 2. A. 72) family gene gene-HME7025_02270 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02270 HME7025_02271 HME7025_02271 HME7025_02271 2677855 2678715 - Carboxymethylenebutenolidase KEGG: sno:Snov_0615 carboxymethylenebutenolidase gene gene-HME7025_02271 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02271 HME7025_02272 HME7025_02272 HME7025_02272 2678764 2680137 - hypothetical protein gene gene-HME7025_02272 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02272 HME7025_02273 HME7025_02273 HME7025_02273 2680134 2680829 - DNA helicase KEGG: ccl:Clocl_2931 ATP-dependent DNA helicase RecG gene gene-HME7025_02273 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02273 HME7025_02274 HME7025_02274 cysH cysH 2680930 2681649 + Phosphoadenylyl-sulfate reductase (thioredoxin) Cytoplasm%3B Oxidoreductase.%3B Reduction of activated sulfate into sulfite%3B Belongs to the PAPS reductase family. CysH subfamily%3B KEGG: rga:RGR602_CH01055 phosphoadenosine phosphosulfate reductase gene gene-HME7025_02274 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02274 HME7025_02275 HME7025_02275 cysD cysD 2681665 2682585 + Sulfate adenylyltransferase ATP-binding%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B Belongs to the PAPS reductase family. CysD subfamily%3B KEGG: fty:CH70_1025 sulfate adenylyltransferase subunit 2 gene gene-HME7025_02275 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02275 HME7025_02276 HME7025_02276 HME7025_02276 2682604 2683854 + Sulfate adenylyltransferase ATP-binding%3B GTP-binding%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase.%3B May be the GTPase%2C regulating ATP sulfurylase activity%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain%3B KEGG: msd:MYSTI_04481 bifunctional enzyme CysN/CysC gene gene-HME7025_02276 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02276 HME7025_02277 HME7025_02277 crtZ crtZ 2683857 2684288 - Beta-carotene 3-hydroxylase Carotenoid biosynthesis%3B Oxidoreductase.%3B Catalyzes the hydroxylation reaction from beta-carotene to zeaxanthin. Belongs to the sterol desaturase family%3B KEGG: rsi:Runsl_1382 beta-carotene 3-hydroxylase gene gene-HME7025_02277 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02277 HME7025_02278 HME7025_02278 HME7025_02278 2684421 2687045 + Leucine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Coiled coil%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine%2C to avoid such errors%2C it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner%3B Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily%3B KEGG: bapf:BUMPF009_CDS00155 leucyl-tRNA synthetase gene gene-HME7025_02278 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02278 HME7025_02279 HME7025_02279 HME7025_02279 2687046 2688083 + hypothetical protein gene gene-HME7025_02279 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02279 HME7025_02280 HME7025_02280 HME7025_02280 2688031 2689887 + Putative ABC transporter ATP-binding protein exp8 ATP-binding%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B KEGG: mmt:Metme_4047 ATP-binding cassette%2C subfamily B%2C bacterial MsbA%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene-HME7025_02280 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02280 HME7025_02281 HME7025_02281 HME7025_02281 2689892 2690317 + hypothetical protein gene gene-HME7025_02281 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02281 HME7025_02282 HME7025_02282 HME7025_02282 2690314 2691759 - hypothetical protein gene gene-HME7025_02282 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02282 HME7025_02283 HME7025_02283 HME7025_02283 2691993 2692104 - 5S ribosomal RNA rRNA gene-HME7025_02283 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02283 HME7025_02284 HME7025_02284 HME7025_02284 2692173 2695002 - 23S ribosomal RNA rRNA gene-HME7025_02284 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02284 HME7025_02285 HME7025_02285 HME7025_02285 2695319 2695395 - tRNA-Ala tRNA gene-HME7025_02285 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02285 HME7025_02286 HME7025_02286 HME7025_02286 2695463 2695539 - tRNA-Ile tRNA gene-HME7025_02286 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02286 HME7025_02287 HME7025_02287 HME7025_02287 2695669 2697174 - 16S ribosomal RNA rRNA gene-HME7025_02287 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02287 HME7025_02288 HME7025_02288 HME7025_02288 2697639 2697848 + hypothetical protein gene gene-HME7025_02288 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02288 HME7025_02289 HME7025_02289 HME7025_02289 2698042 2698740 + hypothetical protein gene gene-HME7025_02289 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02289 HME7025_02290 HME7025_02290 HME7025_02290 2698817 2699179 + hypothetical protein gene gene-HME7025_02290 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02290 HME7025_02291 HME7025_02291 HME7025_02291 2699356 2700081 + 23S rRNA pseudouridine(1911/1915/1917) synthase Isomerase%3B tRNA processing.%3B Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: plm:Plim_2721 23S rRNA pseudouridine1911/1915/1917 synthase gene gene-HME7025_02291 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02291 HME7025_02292 HME7025_02292 HME7025_02292 2700083 2700490 - Putative HTH-type transcriptional regulator DNA-binding.%3B Contains 1 HTH rrf2-type DNA-binding domain gene gene-HME7025_02292 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02292 HME7025_02293 HME7025_02293 HME7025_02293 2700627 2701094 - 30S ribosomal protein S7 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B tRNA-binding.%3B One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center%2C probably blocks exit of the E-site tRNA%3B Belongs to the ribosomal protein S7P family gene gene-HME7025_02293 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02293 HME7025_02294 HME7025_02294 HME7025_02294 2701167 2701571 - 30S ribosomal protein S12%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity)%3B Belongs to the ribosomal protein S12P family gene gene-HME7025_02294 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02294 HME7025_02295 HME7025_02295 uxuA uxuA 2701711 2702901 - Mannonate dehydratase Iron%3B Lyase%3B Manganese.%3B Catalyzes the dehydration of D-mannonate%3B Belongs to the mannonate dehydratase family%3B KEGG: kpa:KPNJ1_01749 mannonate dehydratase gene gene-HME7025_02295 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02295 HME7025_02296 HME7025_02296 HME7025_02296 2703338 2704864 - hypothetical protein gene gene-HME7025_02296 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02296 HME7025_02297 HME7025_02297 recQ recQ 2704955 2706877 + DNA helicase ATP-binding%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B SOS response.%3B Involved in the RecF recombination pathwa%3B its gene expression is under the regulation of the SOS system. It is a DNA helicase%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 HRDC domain%3B KEGG: pko:PKOR_21765 ATP-dependent DNA helicase RecQ gene gene-HME7025_02297 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02297 HME7025_02298 HME7025_02298 HME7025_02298 2706838 2709333 - Endopeptidase La ATP-binding%3B Cytoplasm%3B Hydrolase%3B Nucleotide-binding%3B Protease%3B Serine protease%3B Stress response.%3B ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Binds to DNA in a double-stranded%2C site-specific manner%3B Belongs to the peptidase S16 family%3B Contains 1 Lon domain%3B KEGG: wvi:Weevi_1707 ATP-dependent Lon protease gene gene-HME7025_02298 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02298 HME7025_02299 HME7025_02299 HME7025_02299 2709423 2709926 - hypothetical protein gene gene-HME7025_02299 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02299 HME7025_02300 HME7025_02300 rseP rseP 2709930 2711321 - Putative zinc metalloprotease Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Zinc.%3B Belongs to the peptidase M50B family%3B Contains 1 PDZ (DHR) domain%3B KEGG: shg:Sph21_2920 regulator of sigma E protease%3B Metalloendopeptidases gene gene-HME7025_02300 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02300 HME7025_02301 HME7025_02301 HME7025_02301 2711338 2712510 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase Isoprene biosynthesis%3B Metal-binding%3B NADP%3B Oxidoreductase.%3B Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)%3B Belongs to the DXR family%3B KEGG: xtn:FD63_12285 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene gene-HME7025_02301 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02301 HME7025_02302 HME7025_02302 HME7025_02302 2712504 2713127 - hypothetical protein gene gene-HME7025_02302 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02302 HME7025_02303 HME7025_02303 ggpS ggpS 2713176 2714153 - Dimethylallyltranstransferase Carotenoid biosynthesis%3B Chlorophyll biosynthesis%3B Cyanelle%3B Isoprene biosynthesis%3B Magnesium%3B Metal-binding%3B Photosynthesis%3B Plastid%3B Transferase.%3B Catalyzes the condensation of farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) to yield geranylgeranyl diphosphate (GGPP) needed for biosynthesis of carotenoids and diterpenes%3B Belongs to the FPP/GGPP synthase family%3B KEGG: pit:PIN17_0225 geranylgeranyl diphosphate synthase%2C type II gene gene-HME7025_02303 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02303 HME7025_02304 HME7025_02304 HME7025_02304 2714157 2715371 - NADH:ubiquinone reductase (H(+)-translocating) Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 49 kDa subunit family%3B KEGG: rsi:Runsl_1417 NADH-quinone oxidoreductase subunit D gene gene-HME7025_02304 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02304 HME7025_02305 HME7025_02305 HME7025_02305 2715478 2715729 + 50S ribosomal protein L33 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L33P family gene gene-HME7025_02305 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02305 HME7025_02306 HME7025_02306 HME7025_02306 2715748 2715900 + hypothetical protein gene gene-HME7025_02306 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02306 HME7025_02307 HME7025_02307 HME7025_02307 2716002 2716979 + Signal recognition particle receptor FtsY Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B GTP-binding%3B Membrane%3B Nucleotide-binding%3B Receptor.%3B Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane%2C the hydrolysis of GTP by both Ffh and FtsY%2C and the dissociation of the SRP-FtsY complex into the individual components%3B Belongs to the GTP-binding SRP family. FtsY subfamily gene gene-HME7025_02307 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02307 HME7025_02308 HME7025_02308 qarS qarS 2717029 2718696 - Glutamine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: dal:Dalk_3446 glutaminyl-tRNA synthetase gene gene-HME7025_02308 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02308 HME7025_02309 HME7025_02309 HME7025_02309 2718948 2721422 + hypothetical protein gene gene-HME7025_02309 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02309 HME7025_02310 HME7025_02310 HME7025_02310 2721477 2722526 + hypothetical protein gene gene-HME7025_02310 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02310 HME7025_02311 HME7025_02311 HME7025_02311 2722506 2723828 - GTPase Der GTP-binding%3B Nucleotide-binding%3B Repeat%3B Ribosome biogenesis.%3B GTPase that plays an essential role in the late steps of ribosome biogenesis%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngA (Der) GTPase family%3B Contains 2 EngA-type G (guanine nucleotide-binding) domains%3B Contains 1 KH-like domain gene gene-HME7025_02311 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02311 HME7025_02312 HME7025_02312 HME7025_02312 2723839 2724741 - GTPase Era Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B GTP-binding%3B Membrane%3B Nucleotide-binding%3B Ribosome biogenesis%3B RNA-binding%3B rRNA-binding.%3B An essential GTPase that binds both GDP and GTP%2C with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Era GTPase family%3B Contains 1 Era-type G (guanine nucleotide-binding) domain%3B Contains 1 KH type-2 domain gene gene-HME7025_02312 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02312 HME7025_02313 HME7025_02313 HME7025_02313 2724838 2724913 + tRNA-Met tRNA gene-HME7025_02313 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02313 HME7025_02314 HME7025_02314 HME7025_02314 2725521 2725835 + hypothetical protein gene gene-HME7025_02314 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02314 HME7025_02315 HME7025_02315 HME7025_02315 2725881 2726750 - putative 24.6 kDa protein in ccpA 3'region Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B May be involved in some transport function. Belongs to the MotB family%3B Contains 1 OmpA-like domain gene gene-HME7025_02315 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02315 HME7025_02316 HME7025_02316 HME7025_02316 2726883 2728673 - putative acyl-CoA dehydrogenase FAD%3B Fatty acid metabolism%3B Flavoprotein%3B Lipid degradation%3B Lipid metabolism%3B Oxidoreductase.%3B Involved in the degradation of long-chain fatty acids. Belongs to the acyl-CoA dehydrogenase family%3B KEGG: chy:CHY_1607 null%3B With other acceptors gene gene-HME7025_02316 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02316 HME7025_02317 HME7025_02317 HME7025_02317 2728735 2729193 - hypothetical protein gene gene-HME7025_02317 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02317 HME7025_02318 HME7025_02318 HME7025_02318 2729298 2729858 - hypothetical protein gene gene-HME7025_02318 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02318 HME7025_02319 HME7025_02319 HME7025_02319 2729839 2730069 - ATP synthase epsilon chain ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(1)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transport.%3B Produces ATP from ADP in the presence of a proton gradient across the membrane%3B Belongs to the ATPase epsilon chain family gene gene-HME7025_02319 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02319 HME7025_02320 HME7025_02320 atpD atpD 2730079 2731596 - H(+)-transporting two-sector ATPase ATP synthesis%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B CF(1)%3B Hydrogen ion transport%3B Hydrolase%3B Ion transport%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: sli:Slin_5125 F-type H+-transporting ATPase subunit beta gene gene-HME7025_02320 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02320 HME7025_02321 HME7025_02321 HME7025_02321 2731814 2734018 + hypothetical protein gene gene-HME7025_02321 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02321 HME7025_02322 HME7025_02322 HME7025_02322 2734146 2734508 + 30S ribosomal protein S10 Ribonucleoprotein%3B Ribosomal protein.%3B Involved in the binding of tRNA to the ribosomes%3B Belongs to the ribosomal protein S10P family gene gene-HME7025_02322 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02322 HME7025_02323 HME7025_02323 HME7025_02323 2734642 2735418 - putative glycosyltransferase Glycosyltransferase%3B Transferase.%3B Belongs to the glycosyltransferase 2 family%3B KEGG: ppr:PBPRB0456 biofilm PGA synthesis N-glycosyltransferase PgaC%3B Glycosyltransferases gene gene-HME7025_02323 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02323 HME7025_02324 HME7025_02324 HME7025_02324 2735632 2735787 + 50S ribosomal protein L34 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L34P family gene gene-HME7025_02324 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02324 HME7025_02325 HME7025_02325 rnpA rnpA 2735827 2736252 + Ribonuclease P KEGG: afd:Alfi_1337 ribonuclease P protein component gene gene-HME7025_02325 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02325 HME7025_02326 HME7025_02326 HME7025_02326 2736233 2737903 + C-terminal processing peptidase Hydrolase%3B Protease%3B Secreted%3B Serine protease%3B Signal.%3B Involved in protection of the bacterium from thermal and osmotic stresses%3B Belongs to the peptidase S41A family%3B Contains 1 PDZ (DHR) domain%3B KEGG: fli:Fleli_3667 carboxyl-terminal processing protease gene gene-HME7025_02326 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02326 HME7025_02327 HME7025_02327 HME7025_02327 2737905 2738600 + tRNA N6-adenosine threonylcarbamoyltransferase Acyltransferase%3B Cytoplasm%3B Iron%3B Metal-binding%3B Transferase%3B tRNA processing.%3B Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction%3B Belongs to the KAE1 / TsaD family gene gene-HME7025_02327 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02327 HME7025_02328 HME7025_02328 HME7025_02328 2738600 2739109 + hypothetical protein gene gene-HME7025_02328 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02328 HME7025_02329 HME7025_02329 HME7025_02329 2739227 2742406 - Histone-lysine N-methyltransferase%2C H3 lysine-79 specific Chromatin regulator%3B DNA damage%3B DNA repair%3B Methyltransferase%3B Nucleus%3B Repeat%3B S-adenosyl-L-methionine%3B Transcription%3B Transcription regulation%3B Transferase.%3B Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing%2C correct growth and development%2C and for resistance to DNA damage induced by UV LIGHT%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family%3B Contains 1 DOT1 domain gene gene-HME7025_02329 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02329 HME7025_02330 HME7025_02330 HME7025_02330 2742412 2742633 + hypothetical protein gene gene-HME7025_02330 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02330 HME7025_02331 HME7025_02331 HME7025_02331 2742651 2743541 + uncharacterized protein Kinase%3B Transferase.%3B Belongs to the fructosamine kinase family%3B KEGG: gfo:GFO_0278 null%3B Phosphotransferases with an alcohol group as acceptor gene gene-HME7025_02331 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02331 HME7025_02332 HME7025_02332 ispH ispH 2743538 2744854 - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3Fe-4S%3B Chloroplast%3B Iron%3B Iron-sulfur%3B Isoprene biosynthesis%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Plastid%3B Transit peptide.%3B Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is essential for chloroplast development%3B Belongs to the IspH family%3B KEGG: sru:SRU_1880 4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene gene-HME7025_02332 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02332 HME7025_02333 HME7025_02333 HME7025_02333 2745065 2745679 + hypothetical protein gene gene-HME7025_02333 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02333 HME7025_02334 HME7025_02334 HME7025_02334 2745696 2746061 + hypothetical protein gene gene-HME7025_02334 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02334 HME7025_02335 HME7025_02335 xthA xthA 2746066 2746827 + Exodeoxyribonuclease III DNA damage%3B DNA repair%3B Lyase%3B Magnesium%3B Metal-binding%3B Nucleus.%3B Belongs to the DNA repair enzymes AP/ExoA family%3B KEGG: pae:PA5332 exodeoxyribonuclease III gene gene-HME7025_02335 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02335 HME7025_02336 HME7025_02336 HME7025_02336 2746835 2747137 + NADH:ubiquinone reductase (H(+)-translocating) 2Fe-2S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Transport.%3B Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Belongs to the 2Fe2S Shethna-type ferredoxin family%3B KEGG: deh:cbdb_A846 NADH-quinone oxidoreductase subunit F gene gene-HME7025_02336 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02336 HME7025_02337 HME7025_02337 HME7025_02337 2747146 2747769 + hypothetical protein gene gene-HME7025_02337 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02337 HME7025_02338 HME7025_02338 HME7025_02338 2747748 2748455 - Putative HAD-hydrolase YfnB Hydrolase.%3B Belongs to the HAD-like hydrolase superfamily. YjjG family gene gene-HME7025_02338 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02338 HME7025_02339 HME7025_02339 HME7025_02339 2748509 2749318 + DNA-directed DNA polymerase Cytoplasm%3B DNA replication%3B DNA-directed DNA polymerase%3B Exonuclease%3B Hydrolase%3B Nuclease%3B Nucleotidyltransferase%3B Transferase.%3B Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity%3B Belongs to the DNA polymerase type-C family. PolC subfamily%3B Contains 1 exonuclease domain%3B KEGG: lby:Lbys_2788 DNA polymerase III subunit epsilon gene gene-HME7025_02339 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02339 HME7025_02340 HME7025_02340 HME7025_02340 2749424 2749753 + NADH:ubiquinone reductase (H(+)-translocating) Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 4L family%3B KEGG: pko:PKOR_03655 NADH-quinone oxidoreductase subunit K gene gene-HME7025_02340 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02340 HME7025_02341 HME7025_02341 HME7025_02341 2749784 2751664 + NADH:ubiquinone reductase (H(+)-translocating) Electron transport%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone.%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I subunit 5 family%3B KEGG: dfe:Dfer_3898 NADH-quinone oxidoreductase subunit L gene gene-HME7025_02341 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02341 HME7025_02342 HME7025_02342 HME7025_02342 2751687 2753135 + NADH:ubiquinone reductase (H(+)-translocating) Electron transport%3B Membrane%3B Mitochondrion%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone.%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)%3B Belongs to the complex I subunit 4 family%3B KEGG: das:Daes_1299 NADH-quinone oxidoreductase subunit M gene gene-HME7025_02342 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02342 HME7025_02343 HME7025_02343 HME7025_02343 2753172 2754569 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 2 family%3B KEGG: sli:Slin_5946 NADH-quinone oxidoreductase subunit N gene gene-HME7025_02343 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02343 HME7025_02344 HME7025_02344 HME7025_02344 2754582 2755076 + hypothetical protein gene gene-HME7025_02344 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02344 HME7025_02345 HME7025_02345 HME7025_02345 2755274 2755447 + hypothetical protein gene gene-HME7025_02345 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02345 HME7025_02346 HME7025_02346 HME7025_02346 2755511 2756134 + hypothetical protein gene gene-HME7025_02346 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02346 HME7025_02347 HME7025_02347 HME7025_02347 2756094 2759435 + hypothetical protein gene gene-HME7025_02347 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02347 HME7025_02348 HME7025_02348 HME7025_02348 2759537 2760718 + hypothetical protein gene gene-HME7025_02348 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02348 HME7025_02349 HME7025_02349 HME7025_02349 2760787 2762055 + DNA-directed RNA polymerase Plasmid.%3B Belongs to the peptidase M16 family%3B KEGG: shn:Shewana3_3939 DNA-directed RNA polymerase gene gene-HME7025_02349 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02349 HME7025_02350 HME7025_02350 HME7025_02350 2762052 2762960 - Adenosine kinase Kinase%3B Transferase.%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: cch:Cag_1382 adenosine kinase gene gene-HME7025_02350 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02350 HME7025_02351 HME7025_02351 HME7025_02351 2762971 2764149 - hypothetical protein gene gene-HME7025_02351 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02351 HME7025_02352 HME7025_02352 carS carS 2764320 2765813 + Cysteine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Zinc.%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: har:HEAR1286 cysteinyl-tRNA synthetase gene gene-HME7025_02352 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02352 HME7025_02353 HME7025_02353 HME7025_02353 2765818 2766558 + hypothetical protein gene gene-HME7025_02353 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02353 HME7025_02354 HME7025_02354 HME7025_02354 2766560 2767423 + RHOMBOID-like protein 12%2C mitochondrial Hydrolase%3B Membrane%3B Mitochondrion%3B Protease%3B Transit peptide%3B Transmembrane%3B Transmembrane helix.%3B Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis. Unable to cleave either of the yeast Pcp1 substrates in yeast cells%3B Belongs to the peptidase S54 family gene gene-HME7025_02354 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02354 HME7025_02355 HME7025_02355 HME7025_02355 2767491 2769443 + 1-deoxy-D-xylulose-5-phosphate synthase Isoprene biosynthesis%3B Magnesium%3B Metal-binding%3B Thiamine biosynthesis%3B Thiamine pyrophosphate%3B Transferase.%3B Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%3B Belongs to the transketolase family. DXPS subfamily%3B KEGG: sht:KO02_00875 1-deoxy-D-xylulose-5-phosphate synthase gene gene-HME7025_02355 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02355 HME7025_02356 HME7025_02356 HME7025_02356 2769558 2771366 + Elongation factor Cytoplasm%3B Elongation factor%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis.%3B Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene-HME7025_02356 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02356 HME7025_02357 HME7025_02357 HME7025_02357 2771399 2773471 - ComE operon protein Cell membrane%3B Competence%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding. To H. influenzae REC2%2C N. gonorrhoeae ComA and E. coli YcaI gene gene-HME7025_02357 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02357 HME7025_02358 HME7025_02358 nadD nadD 2773490 2774062 - Nicotinate-nucleotide adenylyltransferase ATP-binding%3B NAD%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Pyridine nucleotide biosynthesis%3B Transferase.%3B Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)%3B Belongs to the NadD family%3B KEGG: doi:FH5T_09880 nicotinate-nucleotide adenylyltransferase gene gene-HME7025_02358 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02358 HME7025_02359 HME7025_02359 HME7025_02359 2774066 2774632 - Guanylate kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Essential for recycling GMP and indirectly%2C cGMP%3B Belongs to the guanylate kinase family%3B Contains 1 guanylate kinase-like domain%3B KEGG: bth:BT_2009 guanylate kinase gene gene-HME7025_02359 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02359 HME7025_02360 HME7025_02360 HME7025_02360 2774653 2774925 - hypothetical protein gene gene-HME7025_02360 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02360 HME7025_02361 HME7025_02361 HME7025_02361 2774979 2775593 - ECF RNA polymerase sigma factor EcfG DNA-binding%3B Sigma factor%3B Stress response%3B Transcription%3B Transcription regulation.%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity). Regulates expression of hpnP under a variety of stresses%2C including high temperature%2C pH stress%2C and presence of nonionic osmolytes (PubMed:23524612)%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene-HME7025_02361 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02361 HME7025_02362 HME7025_02362 HME7025_02362 2775685 2776194 - hypothetical protein gene gene-HME7025_02362 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02362 HME7025_02363 HME7025_02363 HME7025_02363 2776196 2777035 - hypothetical protein gene gene-HME7025_02363 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02363 HME7025_02364 HME7025_02364 HME7025_02364 2777053 2778078 - MreB-like protein Belongs to the FtsA/MreB family gene gene-HME7025_02364 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02364 HME7025_02365 HME7025_02365 HME7025_02365 2778394 2779320 + putative HTH-type transcriptional regulator DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene-HME7025_02365 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02365 HME7025_02366 HME7025_02366 rluB rluB 2779401 2781365 - 23S rRNA pseudouridine(2605) synthase Isomerase%3B RNA-binding%3B rRNA processing.%3B Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: nda:Ndas_0976 23S rRNA pseudouridine2605 synthase gene gene-HME7025_02366 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02366 HME7025_02367 HME7025_02367 HME7025_02367 2781503 2783527 + Outer membrane lipoprotein Omp16 Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal.%3B Belongs to the OmpA family. Pal subfamily%3B Contains 1 OmpA-like domain gene gene-HME7025_02367 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02367 HME7025_02368 HME7025_02368 HME7025_02368 2783529 2784869 + Dihydroorotase Hydrolase%3B Metal-binding%3B Pyrimidine biosynthesis%3B Zinc.%3B Belongs to the DHOase family. Type 2 subfamily%3B KEGG: cpi:Cpin_7096 dihydroorotase gene gene-HME7025_02368 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02368 HME7025_02369 HME7025_02369 HME7025_02369 2784866 2785540 - hypothetical protein gene gene-HME7025_02369 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02369 HME7025_02370 HME7025_02370 rnhB rnhB 2785621 2786208 + Ribonuclease H Cytoplasm%3B Endonuclease%3B Hydrolase%3B Manganese%3B Metal-binding%3B Nuclease.%3B Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase HII family%3B KEGG: acd:AOLE_13575 ribonuclease HII gene gene-HME7025_02370 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02370 HME7025_02371 HME7025_02371 aprX aprX 2786245 2790222 + Pyrolysin Glycoprotein%3B Hydrolase%3B Protease%3B Repeat%3B Serine protease%3B Signal%3B Zymogen.%3B Belongs to the peptidase S8 family%3B Contains 2 peptidase S8 domains%3B KEGG: tte:TTE0824 serine protease AprX%3B Serine endopeptidases gene gene-HME7025_02371 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02371 HME7025_02372 HME7025_02372 HME7025_02372 2790219 2791211 - Alcohol dehydrogenase Cytoplasm%3B NADP%3B Oxidoreductase.%3B Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA%3B Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily%3B KEGG: par:Psyc_0011 alcohol dehydrogenase gene gene-HME7025_02372 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02372 HME7025_02373 HME7025_02373 HME7025_02373 2791217 2791954 - hypothetical protein gene gene-HME7025_02373 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02373 HME7025_02374 HME7025_02374 HME7025_02374 2791960 2792898 - GDP-L-fucose synthase Acetylation%3B Isomerase%3B Multifunctional enzyme%3B NADP%3B Oxidoreductase.%3B Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose%2C involving an epimerase and a reductase reaction. Not involved in the synthesis of GDP-L- galactose from GDP-D-manose%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily%3B KEGG: pstt:CH92_06070 GDP-L-fucose synthase gene gene-HME7025_02374 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02374 HME7025_02375 HME7025_02375 HME7025_02375 2793019 2793957 + hypothetical protein gene gene-HME7025_02375 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02375 HME7025_02376 HME7025_02376 HME7025_02376 2793957 2794310 + hypothetical protein gene gene-HME7025_02376 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02376 HME7025_02377 HME7025_02377 cynT cynT 2794355 2795884 + Carbonate dehydratase Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH%3B Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain%3B KEGG: aci:ACIAD3384 carbonic anhydrase gene gene-HME7025_02377 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02377 HME7025_02378 HME7025_02378 HME7025_02378 2795887 2796528 + Carbonate dehydratase Lyase%3B Metal-binding%3B Zinc.%3B Belongs to the beta-class carbonic anhydrase family%3B KEGG: ctm:Cabther_A0899 carbonic anhydrase gene gene-HME7025_02378 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02378 HME7025_02379 HME7025_02379 darS darS 2796523 2798283 - Aspartate--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis.%3B Catalyzes the attachment of glutamate to tRNA(Asp) in a two-step reaction: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: esi:Exig_2086 aspartyl-tRNA synthetase gene gene-HME7025_02379 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02379 HME7025_02380 HME7025_02380 crtI crtI 2798383 2799858 + All-trans-zeta-carotene desaturase Carotenoid biosynthesis%3B Chlorophyll biosynthesis%3B Oxidoreductase%3B Photosynthesis.%3B Catalyzes the introduction of C-3%2C4 double bonds into 1- hydroxyneurosporene (1-HO-Neu) to yield demethylspheroidene (DMS)%3B Belongs to the carotenoid/retinoid oxidoreductase family%3B KEGG: tsa:AciPR4_3646 phytoene desaturase gene gene-HME7025_02380 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02380 HME7025_02381 HME7025_02381 HME7025_02381 2799881 2800354 + hypothetical protein gene gene-HME7025_02381 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02381 HME7025_02382 HME7025_02382 kdsD kdsD 2800357 2801349 - Arabinose-5-phosphate isomerase Carbohydrate metabolism%3B CBS domain%3B Isomerase%3B Metal-binding%3B Repeat%3B Zinc.%3B Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P)%3B Belongs to the SIS family. GutQ/KpsF subfamily%3B Contains 2 CBS domains%3B Contains 1 SIS domain%3B KEGG: cmr:Cycma_2796 arabinose-5-phosphate isomerase gene gene-HME7025_02382 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02382 HME7025_02383 HME7025_02383 HME7025_02383 2801414 2803735 + DNA helicase ATP-binding%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding.%3B DNA helicase%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: plt:Plut_1667 ATP-dependent DNA helicase RecQ gene gene-HME7025_02383 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02383 HME7025_02384 HME7025_02384 purD purD 2803744 2805030 + Phosphoribosylamine--glycine ligase ATP-binding%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide-binding%3B Purine biosynthesis.%3B Belongs to the GARS family%3B Contains 1 ATP-grasp domain%3B KEGG: plu:plu0494 phosphoribosylamine--glycine ligase gene gene-HME7025_02384 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02384 HME7025_02385 HME7025_02385 HME7025_02385 2805055 2806458 + Stage 0 sporulation protein YaaT Cytoplasm%3B Sporulation.%3B Essential for the phosphorelay during initiation of sporulation. May control the level of phosphorylated spo0A through spo0E activity during sporulation%3B Contains 1 PSP1 C-terminal domain gene gene-HME7025_02385 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02385 HME7025_02386 HME7025_02386 HME7025_02386 2806433 2806918 + hypothetical protein gene gene-HME7025_02386 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02386 HME7025_02387 HME7025_02387 HME7025_02387 2806923 2807405 + HTH-type transcriptional regulator LrpC DNA-binding%3B Transcription%3B Transcription regulation.%3B Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition. Contains 1 HTH asnC-type DNA-binding domain gene gene-HME7025_02387 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02387 HME7025_02388 HME7025_02388 HME7025_02388 2807478 2808575 + uncharacterized protein Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene-HME7025_02388 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02388 HME7025_02389 HME7025_02389 HME7025_02389 2808583 2809629 + hypothetical protein gene gene-HME7025_02389 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02389 HME7025_02390 HME7025_02390 HME7025_02390 2809638 2812742 + Multidrug resistance protein MdtC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtC subfamily gene gene-HME7025_02390 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02390 HME7025_02391 HME7025_02391 ribD ribD 2812735 2813763 + Diaminohydroxyphosphoribosylaminopyrimidine deaminase Hydrolase%3B Metal-binding%3B Multifunctional enzyme%3B NADP%3B Oxidoreductase%3B Riboflavin biosynthesis%3B Zinc.%3B Converts 2%2C5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2%2C4(1h%2C3h)- pyrimidinedione 5'-phosphate. In the N-terminal sectio%3B belongs to the cytidine and deoxycytidylate deaminase family%3B In the C-terminal sectio%3B belongs to the HTP reductase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: hmr:Hipma_1438 diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase gene gene-HME7025_02391 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02391 HME7025_02392 HME7025_02392 HME7025_02392 2813755 2815077 - Divalent metal cation transporter MntH Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B H(+)-stimulated%2C divalent metal cation uptake system%3B Belongs to the NRAMP family gene gene-HME7025_02392 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02392 HME7025_02393 HME7025_02393 HME7025_02393 2815207 2815869 + Diphtheria toxin repressor Cytoplasm%3B DNA-binding%3B Iron%3B Repressor%3B Transcription%3B Transcription regulation.%3B Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess (By similarity)%3B Contains 1 HTH dtxR-type DNA-binding domain gene gene-HME7025_02393 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02393 HME7025_02394 HME7025_02394 HME7025_02394 2815891 2818797 - Non-specific serine/threonine protein kinase ATP-binding%3B Chromatin regulator%3B Coiled coil%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Nucleus%3B Phosphoprotein%3B Transcription%3B Transcription regulation.%3B DNA helicase and probable main scaffold component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation%2C DNA replication and probably DNA repair%3B Belongs to the SNF2/RAD54 helicase family%3B Contains 1 DBINO domain%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: rrs:RoseRS_3980 non-specific serine/threonine protein kinase gene gene-HME7025_02394 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02394 HME7025_02395 HME7025_02395 prmA prmA 2818940 2819767 - Ribosomal protein L11 methyltransferase Cytoplasm%3B Methyltransferase%3B Transferase.%3B Methylates ribosomal protein L11%3B Belongs to the methyltransferase superfamily. PrmA family%3B KEGG: evi:Echvi_1197 ribosomal protein L11 methyltransferase%3B Methyltransferases gene gene-HME7025_02395 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02395 HME7025_02396 HME7025_02396 HME7025_02396 2819774 2820721 - hypothetical protein gene gene-HME7025_02396 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02396 HME7025_02397 HME7025_02397 HME7025_02397 2820730 2821530 - N-acetylmuramoyl-L-alanine amidase Cell wall%3B Cell wall biogenesis/degradation%3B Competence%3B Hydrolase%3B Metal-binding%3B Repeat%3B Secreted%3B Sporulation%3B Zinc.%3B Autolysins are involved in some important biological processes such as cell separation%2C cell-wall turnover%2C competence for genetic transformation%2C formation of the flagella - in particular of its basal body - and sporulation. CwlC is able to hydrolyze type A cell walls such as B. subtilis. Its main function is to lyze the mother cell wall peptidoglycan%2C playing a role during sporulation%3B Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family%3B Contains 1 SPOR domain%3B KEGG: buh:BUAMB_549 N-acetylmuramoyl-L-alanine amidase gene gene-HME7025_02397 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02397 HME7025_02398 HME7025_02398 HME7025_02398 2821693 2824410 + hypothetical protein gene gene-HME7025_02398 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02398 HME7025_02399 HME7025_02399 msrA msrA 2824407 2825066 - Peptide-methionine (S)-S-oxide reductase Oxidoreductase.%3B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)%3B Belongs to the MsrA Met sulfoxide reductase family%3B KEGG: nii:Nit79A3_0601 peptide-methionine (S)-S-oxide reductase gene gene-HME7025_02399 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02399 HME7025_02400 HME7025_02400 HME7025_02400 2825165 2825764 + hypothetical protein gene gene-HME7025_02400 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02400 HME7025_02401 HME7025_02401 HME7025_02401 2825761 2827689 - putative polysaccharide biosynthesis protein EpsC Cell membrane%3B Exopolysaccharide synthesis%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Involved in biofilm formation%3B Belongs to the polysaccharide synthase family gene gene-HME7025_02401 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02401 HME7025_02402 HME7025_02402 HME7025_02402 2827793 2828494 - uncharacterized protein gene gene-HME7025_02402 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02402 HME7025_02403 HME7025_02403 thiL thiL 2828496 2829521 - Thiamine-phosphate kinase ATP-binding%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Thiamine biosynthesis%3B Transferase.%3B Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP)%2C the active form of vitamin B1%3B Belongs to the thiamine-monophosphate kinase family%3B KEGG: bvs:BARVI_04050 thiamine-monophosphate kinase gene gene-HME7025_02403 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02403 HME7025_02404 HME7025_02404 HME7025_02404 2829569 2830051 - hypothetical protein gene gene-HME7025_02404 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02404 HME7025_02405 HME7025_02405 HME7025_02405 2830150 2830389 + hypothetical protein gene gene-HME7025_02405 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02405 HME7025_02406 HME7025_02406 HME7025_02406 2830394 2831254 + hypothetical protein gene gene-HME7025_02406 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02406 HME7025_02407 HME7025_02407 HME7025_02407 2831348 2832769 + hypothetical protein gene gene-HME7025_02407 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02407 HME7025_02408 HME7025_02408 carA carA 2832825 2833925 - Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Amino-acid biosynthesis%3B Arginine biosynthesis%3B ATP-binding%3B Glutamine amidotransferase%3B Ligase%3B Nucleotide-binding%3B Pyrimidine biosynthesis.%3B Belongs to the CarA family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: calt:Cal6303_1530 carbamoyl-phosphate synthase small subunit gene gene-HME7025_02408 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02408 HME7025_02409 HME7025_02409 HME7025_02409 2834015 2834632 - 50S ribosomal protein L17 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L17P family gene gene-HME7025_02409 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02409 HME7025_02410 HME7025_02410 rpoA rpoA 2834723 2835712 - DNA-directed RNA polymerase DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Transcription%3B Transferase.%3B DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase alpha chain family%3B KEGG: cmr:Cycma_2616 DNA-directed RNA polymerase subunit alpha gene gene-HME7025_02410 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02410 HME7025_02411 HME7025_02411 HME7025_02411 2835784 2836389 - 30S ribosomal protein S4 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit%3B With S5 and S12 plays an important role in translational accuracy%3B Belongs to the ribosomal protein S4P family%3B Contains 1 S4 RNA-binding domain gene gene-HME7025_02411 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02411 HME7025_02412 HME7025_02412 HME7025_02412 2836493 2836888 - 30S ribosomal protein S11 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Located on the platform of the 30S subunit%2C it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome%3B Belongs to the ribosomal protein S11P family gene gene-HME7025_02412 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02412 HME7025_02413 HME7025_02413 HME7025_02413 2836934 2837311 - Cyanelle 30S ribosomal protein S13 Cyanelle%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Located at the top of the head of the 30S subunit%2C it contacts several helices of the 16S rRNA%3B Belongs to the ribosomal protein S13P family gene gene-HME7025_02413 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02413 HME7025_02414 HME7025_02414 HME7025_02414 2837355 2837471 - 50S ribosomal protein L36 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L36P family gene gene-HME7025_02414 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02414 HME7025_02415 HME7025_02415 HME7025_02415 2837500 2837718 - Translation initiation factor IF-1 Cytoplasm%3B Initiation factor%3B Protein biosynthesis%3B RNA-binding%3B rRNA-binding.%3B One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection%2C yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1%2C IF-2 and IF-3 are released leaving the mature 70S translation initation complex%3B Belongs to the IF-1 family%3B Contains 1 S1-like domain gene gene-HME7025_02415 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02415 HME7025_02416 HME7025_02416 HME7025_02416 2837728 2838534 - Methionyl aminopeptidase Aminopeptidase%3B Hydrolase%3B Metal-binding%3B Protease.%3B Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-%2C Cys%2C Gly%2C Pro%2C Ser%2C Thr%2C or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed%3B Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily%3B KEGG: ilo:IL0846 methionyl aminopeptidase gene gene-HME7025_02416 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02416 HME7025_02417 HME7025_02417 HME7025_02417 2838536 2839855 - Protein translocase subunit SecY Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7%2C and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently%3B Belongs to the SecY/SEC61-alpha family gene gene-HME7025_02417 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02417 HME7025_02418 HME7025_02418 HME7025_02418 2839873 2840319 - 50S ribosomal protein L15 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds to the 23S rRNA%3B Belongs to the ribosomal protein L15P family gene gene-HME7025_02418 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02418 HME7025_02419 HME7025_02419 HME7025_02419 2840365 2840544 - 50S ribosomal protein L30 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L30P family gene gene-HME7025_02419 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02419 HME7025_02420 HME7025_02420 HME7025_02420 2840580 2841098 - 30S ribosomal protein Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B With S4 and S12 plays an important role in translational accuracy%3B Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body%3B Belongs to the ribosomal protein S5P family%3B Contains 1 S5 DRBM domain gene gene-HME7025_02420 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02420 HME7025_02421 HME7025_02421 HME7025_02421 2841107 2841454 - 50S ribosomal protein L18 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance%3B Belongs to the ribosomal protein L18P family gene gene-HME7025_02421 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02421 HME7025_02422 HME7025_02422 HME7025_02422 2841500 2842057 - 50S ribosomal protein L6 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B This protein binds to the 23S rRNA%2C and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk%2C and near the tRNA binding site of the peptidyltransferase center%3B Belongs to the ribosomal protein L6P family gene gene-HME7025_02422 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02422 HME7025_02423 HME7025_02423 HME7025_02423 2842119 2842514 - 30S ribosomal protein S8 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit%3B Belongs to the ribosomal protein S8P family gene gene-HME7025_02423 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02423 HME7025_02424 HME7025_02424 HME7025_02424 2842591 2842860 - 30S ribosomal protein S14 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds 16S rRNA%2C required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site%3B Belongs to the ribosomal protein S14P family gene gene-HME7025_02424 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02424 HME7025_02425 HME7025_02425 HME7025_02425 2842900 2843484 - 50S ribosomal protein L5 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B tRNA-binding.%3B This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b)%2C connecting the 2 subunit%3B this bridge is implicated in subunit movement. Contacts the P site tRN%3B the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs%3B Belongs to the ribosomal protein L5P family gene gene-HME7025_02425 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02425 HME7025_02426 HME7025_02426 HME7025_02426 2843499 2843834 - 50S ribosomal protein L24 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B One of two assembly initiator proteins%2C it binds directly to the 5'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit%3B Belongs to the ribosomal protein L24P family gene gene-HME7025_02426 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02426 HME7025_02427 HME7025_02427 HME7025_02427 2843876 2844244 - 50S ribosomal protein L14 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome%3B Belongs to the ribosomal protein L14P family gene gene-HME7025_02427 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02427 HME7025_02428 HME7025_02428 HME7025_02428 2844291 2844548 - 30S ribosomal protein S17 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B One of the primary rRNA binding proteins%2C it binds specifically to the 5'-end of 16S ribosomal RNA%3B Belongs to the ribosomal protein S17P family gene gene-HME7025_02428 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02428 HME7025_02429 HME7025_02429 HME7025_02429 2844618 2844809 - 50S ribosomal protein L29 Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L29P family gene gene-HME7025_02429 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02429 HME7025_02430 HME7025_02430 HME7025_02430 2844849 2845268 - 50S ribosomal protein L16%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein.%3B Belongs to the ribosomal protein L16P family gene gene-HME7025_02430 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02430 HME7025_02431 HME7025_02431 HME7025_02431 2845312 2846139 - 30S ribosomal protein S3 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome%2C positioning it for translation%3B Belongs to the ribosomal protein S3P family%3B Contains 1 KH type-2 domain gene gene-HME7025_02431 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02431 HME7025_02432 HME7025_02432 HME7025_02432 2846163 2846540 - 50S ribosomal protein L22 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B This protein binds specifically to 23S rRN%3B its binding is stimulated by other ribosomal proteins%2C e. g. L4%2C L17%2C and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)%3B The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit%2C while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome%3B Belongs to the ribosomal protein L22P family gene gene-HME7025_02432 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02432 HME7025_02433 HME7025_02433 HME7025_02433 2846580 2846858 - 30S ribosomal protein S19%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA%3B Belongs to the ribosomal protein S19P family gene gene-HME7025_02433 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02433 HME7025_02434 HME7025_02434 HME7025_02434 2846862 2847689 - 50S ribosomal protein L2 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome%2C for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activit%3B this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome%3B Belongs to the ribosomal protein L2P family gene gene-HME7025_02434 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02434 HME7025_02435 HME7025_02435 HME7025_02435 2847737 2848024 - 50S ribosomal protein L23%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B Binds to 23S rRNA%3B Belongs to the ribosomal protein L23P family gene gene-HME7025_02435 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02435 HME7025_02436 HME7025_02436 HME7025_02436 2848062 2848691 - 50S ribosomal protein L4 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B One of the primary rRNA binding proteins%2C this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome%3B Forms part of the polypeptide exit tunnel%3B Belongs to the ribosomal protein L4P family gene gene-HME7025_02436 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02436 HME7025_02437 HME7025_02437 HME7025_02437 2848734 2849351 - 50S ribosomal protein L3 Methylation%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding.%3B One of the primary rRNA binding proteins%2C it binds directly near the 3'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B Belongs to the ribosomal protein L3P family gene gene-HME7025_02437 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02437 HME7025_02438 HME7025_02438 fbaA fbaA 2849881 2850963 + Fructose-bisphosphate aldolase Glycolysis%3B Lyase%3B Metal-binding%3B Zinc.%3B Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1%2C6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis%3B Belongs to the class II fructose-bisphosphate aldolase family%3B KEGG: bak:BAKON_454 fructose-bisphosphate aldolase%2C class II gene gene-HME7025_02438 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02438 HME7025_02439 HME7025_02439 HME7025_02439 2851179 2851781 - hypothetical protein gene gene-HME7025_02439 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02439 HME7025_02440 HME7025_02440 met8 met8 2852062 2852646 - Precorrin-2 dehydrogenase Cobalamin biosynthesis%3B Lyase%3B Methyltransferase%3B Multifunctional enzyme%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Porphyrin biosynthesis%3B S-adenosyl-L-methionine%3B Transferase.%3B Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: bbl:BLBBGE_281 precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase gene gene-HME7025_02440 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02440 HME7025_02441 HME7025_02441 rlmN rlmN 2852656 2853717 - 23S rRNA (adenine(2503)-C(2))-methyltransferase 4Fe-4S%3B Cytoplasm%3B Disulfide bond%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing.%3B Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity%3B Belongs to the radical SAM superfamily. RlmN family%3B KEGG: sags:SaSA20_0446 23S rRNA (adenine2503-C2)-methyltransferase gene gene-HME7025_02441 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02441 HME7025_02442 HME7025_02442 HME7025_02442 2853719 2854171 - uncharacterized protein gene gene-HME7025_02442 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02442 HME7025_02443 HME7025_02443 HME7025_02443 2854176 2855708 - Indole-3-acetic acid-amido synthetase GH3.3 Ligase.%3B Catalyzes the synthesis of indole-3-acetic acid (IAA)- amino acid conjugates%2C providing a mechanism for the plant to cope with the presence of excess auxin. Strongly reactive with Glu%2C Gln%2C Trp%2C Asp%2C Ala%2C Leu%2C Phe%2C Gly%2C Tyr%2C Met%2C Ile and Val. Little or no product formation with His%2C Ser%2C Thr%2C Arg%2C Lys%2C or Cys. Also active on pyruvic and butyric acid analogs of IAA%2C PAA and the synthetic auxin naphthaleneacetic acid (NAA). The two chlorinated synthetic auxin herbicides 2%2C4-D and 3%2C6-dichloro-o-anisic acid (dicamba) cannot be used as substrates%3B Belongs to the IAA-amido conjugating enzyme family gene gene-HME7025_02443 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02443 HME7025_02444 HME7025_02444 HME7025_02444 2855708 2856559 - Glycerophosphodiester phosphodiesterase Hydrolase%3B Lipid metabolism%3B Membrane%3B Mitochondrion%3B Transmembrane%3B Transmembrane helix.%3B Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C- type degradation mechanism%3B Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Contains 1 GP-PDE domain%3B KEGG: pms:KNP414_03803 glycerophosphoryl diester phosphodiesterase gene gene-HME7025_02444 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02444 HME7025_02445 HME7025_02445 HME7025_02445 2856604 2856945 - hypothetical protein gene gene-HME7025_02445 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02445 HME7025_02446 HME7025_02446 HME7025_02446 2857046 2857918 + uncharacterized protein To M. avium MAV169%3B KEGG: mtuh:I917_10510 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene-HME7025_02446 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02446 HME7025_02447 HME7025_02447 HME7025_02447 2857918 2858778 + hypothetical protein gene gene-HME7025_02447 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02447 HME7025_02448 HME7025_02448 HME7025_02448 2858775 2859767 + hypothetical protein gene gene-HME7025_02448 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02448 HME7025_02449 HME7025_02449 ispE ispE 2859769 2860575 + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase ATP-binding%3B Isoprene biosynthesis%3B Kinase%3B Nucleotide-binding%3B Transferase.%3B Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol%3B Belongs to the GHMP kinase family. IspE subfamily%3B KEGG: bhl:Bache_2195 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase gene gene-HME7025_02449 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02449 HME7025_02450 HME7025_02450 HME7025_02450 2860572 2861702 - hypothetical protein gene gene-HME7025_02450 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02450 HME7025_02451 HME7025_02451 HME7025_02451 2861695 2866023 - Cation efflux system protein CzcA Cadmium resistance%3B Cell membrane%3B Cobalt%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Zinc.%3B Has a low cation transport activity for cobalt%2C it is essential for the expression of cobalt%2C zinc%2C and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC). Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene-HME7025_02451 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02451 HME7025_02452 HME7025_02452 HME7025_02452 2866068 2866451 - hypothetical protein gene gene-HME7025_02452 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02452 HME7025_02453 HME7025_02453 HME7025_02453 2866566 2867183 + hypothetical protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the DedA family gene gene-HME7025_02453 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02453 HME7025_02454 HME7025_02454 HME7025_02454 2867183 2867647 + NADH:ubiquinone reductase (H(+)-translocating) Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 3 family%3B KEGG: scl:sce9058 NADH-quinone oxidoreductase subunit A gene gene-HME7025_02454 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02454 HME7025_02455 HME7025_02455 HME7025_02455 2867650 2868786 - hypothetical protein gene gene-HME7025_02455 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02455 HME7025_02456 HME7025_02456 HME7025_02456 2868894 2870456 + Putative cysteine ligase BshC Coiled coil%3B Ligase.%3B Belongs to the BshC family gene gene-HME7025_02456 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02456 HME7025_02457 HME7025_02457 HME7025_02457 2870449 2871483 + uncharacterized protein Contains 1 rhodanese domain%3B KEGG: hav:AT03_10070 tRNA 2-selenouridine synthase%3B Selenotransferases gene gene-HME7025_02457 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02457 HME7025_02458 HME7025_02458 cysE cysE 2871490 2872293 + Serine O-acetyltransferase Acyltransferase%3B Amino-acid biosynthesis%3B Cysteine biosynthesis%3B Cytoplasm%3B Repeat%3B Transferase.%3B Belongs to the transferase hexapeptide repeat family%3B KEGG: chu:CHU_0685 serine O-acetyltransferase gene gene-HME7025_02458 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02458 HME7025_02459 HME7025_02459 cysK cysK 2872295 2873170 + Cysteine synthase Amino-acid biosynthesis%3B Cysteine biosynthesis%3B Cytoplasm%3B Lyase%3B Pyridoxal phosphate%3B Transferase.%3B Involved in maintaining Cys homeostasis through the desulfuration of L-cysteine. Modulates the generation of the signaling molecule sulfide in plant cytosol. Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) and is therefore not an enzymatically true OASTL protein%3B Belongs to the cysteine synthase/cystathionine beta- synthase family%3B KEGG: hoh:Hoch_4175 cysteine synthase A gene gene-HME7025_02459 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02459 HME7025_02460 HME7025_02460 HME7025_02460 2873156 2873731 - hypothetical protein gene gene-HME7025_02460 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02460 HME7025_02461 HME7025_02461 HME7025_02461 2873833 2874039 - hypothetical protein gene gene-HME7025_02461 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02461 HME7025_02462 HME7025_02462 HME7025_02462 2874245 2875543 - hypothetical protein gene gene-HME7025_02462 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02462 HME7025_02463 HME7025_02463 HME7025_02463 2875555 2878560 - N-acetylglucosamine-6-phosphate deacetylase KEGG: rba:RB977 N-acetylglucosamine-6-phosphate deacetylase gene gene-HME7025_02463 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02463 HME7025_02464 HME7025_02464 HME7025_02464 2878625 2880010 - hypothetical protein gene gene-HME7025_02464 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02464 HME7025_02465 HME7025_02465 HME7025_02465 2880257 2881996 + hypothetical protein gene gene-HME7025_02465 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02465 HME7025_02466 HME7025_02466 HME7025_02466 2881999 2882409 - hypothetical protein gene gene-HME7025_02466 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02466 HME7025_02467 HME7025_02467 HME7025_02467 2882451 2885003 + hypothetical protein gene gene-HME7025_02467 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02467 HME7025_02468 HME7025_02468 HME7025_02468 2884993 2887011 + hypothetical protein gene gene-HME7025_02468 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02468 HME7025_02469 HME7025_02469 axy8 axy8 2887256 2889673 - Alpha-L-fucosidase Apoplast%3B Glycoprotein%3B Glycosidase%3B Hydrolase%3B Secreted%3B Signal.%3B Hydrolyzes alpha-1%2C2-linked fucose. Also active on fucosylated xyloglucan oligosaccharides. No activity with 3- fucosyllactose%2C p-nitrophenyl-alpha-I-fucopyranoside%2C lacto-N- fucopentaose II%2C lacto-N-fucopentaose III or alpha 1%2C6-fucosylated chitopentaose. Involved in apoplastic xyloglucan metabolism%3B Belongs to the glycosyl hydrolase 95 family%3B KEGG: pod:PODO_14820 alpha-L-fucosidase 2 gene gene-HME7025_02469 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02469 HME7025_02470 HME7025_02470 iolI iolI 2889682 2890662 - 2-keto-myo-inositol isomerase KEGG: rba:RB9367 2-keto-myo-inositol isomerase gene gene-HME7025_02470 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02470 HME7025_02471 HME7025_02471 HME7025_02471 2890810 2890882 - tRNA-Phe tRNA gene-HME7025_02471 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02471 HME7025_02472 HME7025_02472 HME7025_02472 2891022 2891753 + Iron-chelate-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Nucleotide-binding%3B Transport.%3B Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: eco:b4287 iron complex transport system ATP-binding protein gene gene-HME7025_02472 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02472 HME7025_02473 HME7025_02473 metB metB 2891879 2893006 + Cystathionine gamma-synthase Amino-acid biosynthesis%3B Cysteine biosynthesis%3B Cytoplasm%3B Lyase%3B Pyridoxal phosphate.%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: psd:DSC_03380 cystathionine gamma-synthase gene gene-HME7025_02473 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02473 HME7025_02474 HME7025_02474 HME7025_02474 2893090 2894499 + hypothetical protein gene gene-HME7025_02474 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02474 HME7025_02475 HME7025_02475 HME7025_02475 2894502 2895290 - hypothetical protein gene gene-HME7025_02475 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02475 HME7025_02476 HME7025_02476 HME7025_02476 2895443 2896813 - putative alginate O-acetylase AlgI Acyltransferase%3B Alginate biosynthesis%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix.%3B Together with AlgJ and AlgF%2C forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate increases cyst resistance to desiccation. Belongs to the membrane-bound acyltransferase family gene gene-HME7025_02476 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02476 HME7025_02477 HME7025_02477 HME7025_02477 2896815 2898002 - Biotin biosynthesis cytochrome P450 Biotin biosynthesis%3B Disulfide bond%3B Heme%3B Iron%3B Metal-binding%3B Monooxygenase%3B Oxidoreductase.%3B Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid%3B Belongs to the cytochrome P450 family%3B KEGG: gvi:gll1942 null%3B Acting on paired donors%2C with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2) gene gene-HME7025_02477 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02477 HME7025_02478 HME7025_02478 HME7025_02478 2897981 2898211 - hypothetical protein gene gene-HME7025_02478 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02478 HME7025_02479 HME7025_02479 HME7025_02479 2898440 2899912 + hypothetical protein gene gene-HME7025_02479 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02479 HME7025_02480 HME7025_02480 HME7025_02480 2899914 2900801 - UDP-glucose 4-epimerase NAD%3B Plasmid.%3B Putative nucleotide sugar epimerase/dehydrogenase. Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: bmx:BMS_3154 UDP-glucose 4-epimerase gene gene-HME7025_02480 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02480 HME7025_02481 HME7025_02481 HME7025_02481 2900798 2901979 - hypothetical protein gene gene-HME7025_02481 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02481 HME7025_02482 HME7025_02482 HME7025_02482 2901984 2903624 - hypothetical protein gene gene-HME7025_02482 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02482 HME7025_02483 HME7025_02483 HME7025_02483 2903629 2904744 - UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) Cell wall biogenesis/degradation%3B Isomerase%3B Lipopolysaccharide biosynthesis.%3B Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the epimerization of UDP-2%2C3-diacetamido- 2%2C3-dideoxy-alpha-D-glucuronic acid (UDP-alpha-D-GlcNAc3NAcA) to UDP-2%2C3-diacetamido-2%2C3-dideoxy-alpha-D-mannuronic acid (UDP- alpha-D-ManNAc3NAcA). Exhibits high specificity towards the substrate as UDP-alpha-D-GlcNAc%2C UDP-alpha-D-GlcNAcA (UDP-2- acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D- GlcNAc3NAc (UDP-2%2C3-diacetamido-2%2C3-dideoxy-alpha-D-glucose) cannot act as substrates%3B Belongs to the UDP-N-acetylglucosamine 2-epimerase family%3B KEGG: tmb:Thimo_1019 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) gene gene-HME7025_02483 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02483 HME7025_02484 HME7025_02484 HME7025_02484 2904719 2906839 - putative oxidoreductase YrbE Oxidoreductase.%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: sat:SYN_02682 null%3B With NAD(+) or NADP(+) as acceptor gene gene-HME7025_02484 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02484 HME7025_02485 HME7025_02485 asnB asnB 2906926 2908827 - Asparagine synthase (glutamine-hydrolyzing) Amino-acid biosynthesis%3B Asparagine biosynthesis%3B ATP-binding%3B Glutamine amidotransferase%3B Ligase%3B Nucleotide-binding.%3B Belongs to the asparagine synthetase family%3B Contains 1 asparagine synthetase domain%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: bsd:BLASA_0342 asparagine synthase (glutamine-hydrolysing) gene gene-HME7025_02485 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02485 HME7025_02486 HME7025_02486 mgtA mgtA 2908830 2909948 - putative glycosyltransferase Glycosyltransferase%3B Transferase.%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: apn:Asphe3_11220 phosphatidylinositol alpha 1%2C6-mannosyltransferase%3B Hexosyltransferases gene gene-HME7025_02486 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02486 HME7025_02487 HME7025_02487 HME7025_02487 2909949 2911826 - Asparagine synthase (glutamine-hydrolyzing) Amino-acid biosynthesis%3B Asparagine biosynthesis%3B ATP-binding%3B Glutamine amidotransferase%3B Ligase%3B Nucleotide-binding.%3B Main asparagine synthetase in vegetative cells. Belongs to the asparagine synthetase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: bmk:DM80_2572 asparagine synthase (glutamine-hydrolysing) gene gene-HME7025_02487 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02487 HME7025_02488 HME7025_02488 HME7025_02488 2911845 2913206 - hypothetical protein gene gene-HME7025_02488 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02488 HME7025_02489 HME7025_02489 bioC bioC 2913254 2914159 - Malonyl-[acyl-carrier protein] O-methyltransferase KEGG: vpa:VP1115 malonyl-CoA O-methyltransferase gene gene-HME7025_02489 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02489 HME7025_02490 HME7025_02490 tagF tagF 2914388 2915512 - CDP-glycerol glycerophosphotransferase Glycosyltransferase%3B Transferase.%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: cjer:H730_08190 CDP-glycerol glycerophosphotransferase gene gene-HME7025_02490 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02490 HME7025_02491 HME7025_02491 HME7025_02491 2915513 2916973 - hypothetical protein gene gene-HME7025_02491 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02491 HME7025_02492 HME7025_02492 HME7025_02492 2917131 2917874 - hypothetical protein gene gene-HME7025_02492 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02492 HME7025_02493 HME7025_02493 HME7025_02493 2917891 2918445 - Putative acetyltransferase Acyltransferase%3B Repeat%3B Signal%3B Transferase.%3B Putative acetyltransferase that is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP). Belongs to the transferase hexapeptide repeat family%3B KEGG: afm:AFUA_3G03380 null%3B Transferring groups other than amino-acyl groups gene gene-HME7025_02493 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02493 HME7025_02494 HME7025_02494 HME7025_02494 2918457 2919854 - hypothetical protein gene gene-HME7025_02494 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02494 HME7025_02495 HME7025_02495 HME7025_02495 2919889 2921082 - hypothetical protein gene gene-HME7025_02495 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02495 HME7025_02496 HME7025_02496 HME7025_02496 2921092 2921895 - Imidazole glycerol phosphate synthase subunit HisF Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Lyase.%3B IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit%3B Belongs to the HisA/HisF family%3B KEGG: lpm:LP6_0754 cyclase%3B Oxo-acid-lyases gene gene-HME7025_02496 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02496 HME7025_02497 HME7025_02497 HME7025_02497 2921907 2922524 - Imidazole glycerol phosphate synthase subunit HisH Amino-acid biosynthesis%3B Cytoplasm%3B Glutamine amidotransferase%3B Histidine biosynthesis%3B Transferase.%3B IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: cut:CUTER_07145 glutamine amidotransferase%3B Pentosyltransferases gene gene-HME7025_02497 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02497 HME7025_02498 HME7025_02498 pseI pseI 2922540 2923166 - Pseudaminic acid synthase Metal-binding%3B Transferase.%3B Catalyzes the fifth step in the biosynthesis of pseudaminic acid%2C a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2%2C4-diacetamido-2%2C4%2C6-trideoxy-beta-l-altropyranose%2C forming pseudaminic acid (By similarity)%3B Belongs to the pseudaminic acid synthase family%3B Contains 1 AFP-like domain%3B KEGG: jeo:JMA_28170 pseudaminic acid synthase gene gene-HME7025_02498 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02498 HME7025_02499 HME7025_02499 neuB neuB 2923223 2923579 - N-acetylneuraminate synthase Metal-binding%3B Transferase.%3B Catalyzes the fifth step in the biosynthesis of pseudaminic acid%2C a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2%2C4-diacetamido-2%2C4%2C6-trideoxy-beta-l-altropyranose%2C forming pseudaminic acid%3B Belongs to the pseudaminic acid synthase family%3B Contains 1 AFP-like domain%3B KEGG: ilo:IL0519 N-acetylneuraminate synthase gene gene-HME7025_02499 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02499 HME7025_02500 HME7025_02500 HME7025_02500 2923587 2924447 - Methionyl-tRNA formyltransferase Protein biosynthesis%3B Transferase.%3B Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP%3B Belongs to the Fmt family%3B KEGG: jde:Jden_1313 methionyl-tRNA formyltransferase gene gene-HME7025_02500 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02500 HME7025_02501 HME7025_02501 HME7025_02501 2924444 2925004 - hypothetical protein gene gene-HME7025_02501 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02501 HME7025_02502 HME7025_02502 HME7025_02502 2925020 2925805 - Putative imidazole glycerol phosphate synthase subunit hisF2 Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Lyase.%3B IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)%3B Belongs to the HisA/HisF family%3B KEGG: pmt:PMT0100 cyclase%3B Oxo-acid-lyases gene gene-HME7025_02502 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02502 HME7025_02503 HME7025_02503 HME7025_02503 2925805 2926422 - Imidazole glycerol phosphate synthase subunit HisH Amino-acid biosynthesis%3B Cytoplasm%3B Glutamine amidotransferase%3B Histidine biosynthesis%3B Transferase.%3B IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: cff:CFF8240_1352 glutamine amidotransferase%3B Pentosyltransferases gene gene-HME7025_02503 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02503 HME7025_02504 HME7025_02504 HME7025_02504 2926423 2927610 - uncharacterized protein gene gene-HME7025_02504 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02504 HME7025_02505 HME7025_02505 HME7025_02505 2927635 2928942 - Glutamate-1-semialdehyde 2%2C1-aminomutase Chlorophyll biosynthesis%3B Chloroplast%3B Isomerase%3B Plastid%3B Porphyrin biosynthesis%3B Pyridoxal phosphate%3B Transit peptide.%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily%3B KEGG: bfg:BF638R_3764 glutamate-1-semialdehyde 2%2C1-aminomutase gene gene-HME7025_02505 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02505 HME7025_02506 HME7025_02506 HME7025_02506 2928942 2929682 - uncharacterized protein gene gene-HME7025_02506 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02506 HME7025_02507 HME7025_02507 HME7025_02507 2929676 2930524 - hypothetical protein gene gene-HME7025_02507 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02507 HME7025_02508 HME7025_02508 HME7025_02508 2930521 2931069 - Ribosomal-protein-alanine N-acetyltransferase KEGG: lin:lin1806 ribosomal-protein-alanine N-acetyltransferase gene gene-HME7025_02508 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02508 HME7025_02509 HME7025_02509 HME7025_02509 2931062 2932264 - GDP-perosamine synthase Aminotransferase%3B Pyridoxal phosphate%3B Transferase.%3B Catalyzes the second step in the biosynthesis of pseudaminic acid%2C a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2%2C6-dideoxy-beta-L-arabino-4- hexulose as substrate producing UDP-4-amino-4%2C6-dideoxy-beta-L- AltNAc%3B Belongs to the DegT/DnrJ/EryC1 family%3B KEGG: vma:VAB18032_13760 perosamine synthetase gene gene-HME7025_02509 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02509 HME7025_02510 HME7025_02510 wbpP wbpP 2932265 2933278 - UDP-N-acetylglucosamine 4-epimerase Isomerase%3B Lipopolysaccharide biosynthesis.%3B Epimerizes UDP-galactose to UDP-glucose%3B Belongs to the polysaccharide synthase family%3B KEGG: dti:Desti_1226 UDP-N-acetylglucosamine 4-epimerase gene gene-HME7025_02510 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02510 HME7025_02511 HME7025_02511 HME7025_02511 2933299 2934357 - UDP-glucuronate 4-epimerase Capsule biogenesis/degradation%3B Exopolysaccharide synthesis%3B Lyase%3B NAD.%3B Required for the biosynthesis of type 1 capsular polysaccharide. Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: pmb:A9601_13971 UDP-glucuronate 4-epimerase gene gene-HME7025_02511 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02511 HME7025_02512 HME7025_02512 wbpO wbpO 2934377 2935654 - Vi polysaccharide biosynthesis protein VipA/TviB NAD%3B Oxidoreductase.%3B Belongs to the UDP-glucose/GDP-mannose dehydrogenase family%3B KEGG: par:Psyc_0650 UDP-N-acetyl-D-galactosamine dehydrogenase%3B With NAD(+) or NADP(+) as acceptor gene gene-HME7025_02512 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02512 HME7025_02513 HME7025_02513 HME7025_02513 2935661 2936200 - hypothetical protein gene gene-HME7025_02513 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02513 HME7025_02514 HME7025_02514 HME7025_02514 2936393 2936953 + Exopolysaccharide production protein PSS Exopolysaccharide synthesis%3B Nodulation.%3B Belongs to the bacterial sugar transferase family gene gene-HME7025_02514 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02514 HME7025_02515 HME7025_02515 recJ recJ 2937183 2938913 + Single-stranded-DNA-specific exonuclease RecJ Coiled coil%3B DNA-binding%3B Exonuclease%3B Hydrolase%3B Nuclease.%3B Putative single-stranded-DNA-specific exonuclease (By similarity). RecA thread formation during DNA double-strand break repair requires RecJ or AadAB%3B Belongs to the RecJ family%3B Contains 1 OB DNA-binding domain%3B KEGG: trs:Terro_1876 single-stranded-DNA-specific exonuclease%3B Acting on ester bonds gene gene-HME7025_02515 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02515 HME7025_02516 HME7025_02516 HME7025_02516 2939281 2939706 + hypothetical protein gene gene-HME7025_02516 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02516 HME7025_02517 HME7025_02517 HME7025_02517 2939898 2942321 - Non-specific serine/threonine protein kinase KEGG: nml:Namu_2474 serine/threonine protein kinase%2C bacterial gene gene-HME7025_02517 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02517 HME7025_02518 HME7025_02518 HME7025_02518 2942425 2943081 - hypothetical protein gene gene-HME7025_02518 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02518 HME7025_02519 HME7025_02519 HME7025_02519 2943185 2945356 - hypothetical protein gene gene-HME7025_02519 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02519 HME7025_02520 HME7025_02520 HME7025_02520 2945366 2946823 - hypothetical protein gene gene-HME7025_02520 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02520 HME7025_02521 HME7025_02521 HME7025_02521 2946828 2949158 - hypothetical protein gene gene-HME7025_02521 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02521 HME7025_02522 HME7025_02522 HME7025_02522 2949158 2950594 - hypothetical protein gene gene-HME7025_02522 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02522 HME7025_02523 HME7025_02523 HME7025_02523 2950627 2953488 - hypothetical protein gene gene-HME7025_02523 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02523 HME7025_02524 HME7025_02524 HME7025_02524 2953528 2955030 - hypothetical protein gene gene-HME7025_02524 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02524 HME7025_02525 HME7025_02525 HME7025_02525 2955041 2958079 - TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_02525 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02525 HME7025_02526 HME7025_02526 HME7025_02526 2958184 2958303 + hypothetical protein gene gene-HME7025_02526 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02526 HME7025_02527 HME7025_02527 HME7025_02527 2958388 2958504 + hypothetical protein gene gene-HME7025_02527 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02527 HME7025_02528 HME7025_02528 HME7025_02528 2958501 2958791 + hypothetical protein gene gene-HME7025_02528 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02528 HME7025_02529 HME7025_02529 HME7025_02529 2958800 2959384 + Non-specific serine/threonine protein kinase KEGG: gba:J421_2130 serine/threonine protein kinase%2C bacterial gene gene-HME7025_02529 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02529 HME7025_02530 HME7025_02530 HME7025_02530 2959505 2960224 + Quercetin 2%2C3-dioxygenase Copper%3B Dioxygenase%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Zinc.%3B Has quercetin 2%2C3-dioxygenase activity in vitro. Its physiological role is unknow%3B however%2C may provide a mechanism that would avoid inhibition of key cellular proteins%2C such as DNA gyrase%2C by quercetin (By similarity)%3B Belongs to the pirin family gene gene-HME7025_02530 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02530 HME7025_02531 HME7025_02531 HME7025_02531 2960260 2960790 + UPF0312 protein Belongs to the UPF0312 family gene gene-HME7025_02531 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02531 HME7025_02532 HME7025_02532 HME7025_02532 2960815 2961135 + hypothetical protein gene gene-HME7025_02532 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02532 HME7025_02533 HME7025_02533 HME7025_02533 2961149 2961529 - hypothetical protein gene gene-HME7025_02533 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02533 HME7025_02534 HME7025_02534 HME7025_02534 2961537 2962424 - putative NTE family protein Belongs to the NTE family%3B Contains 1 patatin domain gene gene-HME7025_02534 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02534 HME7025_02535 HME7025_02535 HME7025_02535 2962545 2962913 + hypothetical protein gene gene-HME7025_02535 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02535 HME7025_02536 HME7025_02536 HME7025_02536 2962921 2964708 - hypothetical protein gene gene-HME7025_02536 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02536 HME7025_02537 HME7025_02537 HME7025_02537 2964840 2965574 - Cytokinin riboside 5'-monophosphate phosphoribohydrolase Cytokinin biosynthesis%3B Hydrolase%3B Plasmid.%3B Catalyzes the hydrolytic removal of ribose 5'- monophosphate from nitrogen N6-modified adenosines%2C the final step of bioactive cytokinin synthesis%3B Belongs to the LOG family gene gene-HME7025_02537 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02537 HME7025_02538 HME7025_02538 HME7025_02538 2965794 2968223 + hypothetical protein gene gene-HME7025_02538 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02538 HME7025_02539 HME7025_02539 HME7025_02539 2968256 2969104 - hypothetical protein gene gene-HME7025_02539 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02539 HME7025_02540 HME7025_02540 HME7025_02540 2969117 2970820 - Quinoprotein glucose dehydrogenase (PQQ%2C quinone) Antibiotic biosynthesis%3B FAD%3B Flavoprotein%3B Oxidoreductase.%3B Glucosaminyl-6'-oxidase involved in the biosynthetic pathway of lividomycin by mediating FAD-dependent dehydrogenation of 6'''-hydroxyparomomycin to paromomycin%3B Belongs to the GMC oxidoreductase family%3B KEGG: sus:Acid_2289 quinoprotein glucose dehydrogenase gene gene-HME7025_02540 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02540 HME7025_02541 HME7025_02541 HME7025_02541 2970824 2971330 - hypothetical protein gene gene-HME7025_02541 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02541 HME7025_02542 HME7025_02542 HME7025_02542 2971431 2972312 - hypothetical protein gene gene-HME7025_02542 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02542 HME7025_02543 HME7025_02543 sgsH sgsH 2972480 2974003 + N-sulfoglucosamine sulfohydrolase Calcium%3B Glycoprotein%3B Hydrolase%3B Metal-binding%3B Secreted%3B Signal.%3B Belongs to the sulfatase family%3B KEGG: gag:Glaag_1823 N-sulfoglucosamine sulfohydrolase gene gene-HME7025_02543 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02543 HME7025_02544 HME7025_02544 HME7025_02544 2974689 2975885 + hypothetical protein gene gene-HME7025_02544 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02544 HME7025_02545 HME7025_02545 lacZ lacZ 2975964 2977775 + Beta-galactosidase Carbohydrate metabolism%3B Cell inner membrane%3B Cell membrane%3B Glycosidase%3B Hydrolase%3B Lipoprotein%3B Membrane%3B Palmitate%3B Polysaccharide degradation%3B Signal.%3B Catalyzes the hydrolysis of terminal non-reducing beta- D-galactose residues in beta-D-galactosides in xyloglucan degradation%2C converting 'L' units to 'X' units%3B Belongs to the glycosyl hydrolase 2 family%3B KEGG: rba:RB3405 beta-galactosidase gene gene-HME7025_02545 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02545 HME7025_02546 HME7025_02546 HME7025_02546 2977838 2978344 + hypothetical protein gene gene-HME7025_02546 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02546 HME7025_02547 HME7025_02547 HME7025_02547 2978345 2979328 - Alkylglycerol monooxygenase Iron%3B Membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the sterol desaturase family. TMEM195 subfamily%3B KEGG: api:100159128 alkylglycerol monooxygenase gene gene-HME7025_02547 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02547 HME7025_02548 HME7025_02548 HME7025_02548 2979383 2980093 - Glucosamine-6-phosphate deaminase Carbohydrate metabolism%3B Hydrolase.%3B Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion%3B Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily%3B KEGG: gka:GK2276 glucosamine-6-phosphate deaminase gene gene-HME7025_02548 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02548 HME7025_02549 HME7025_02549 HME7025_02549 2980117 2981403 - hypothetical protein gene gene-HME7025_02549 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02549 HME7025_02550 HME7025_02550 HME7025_02550 2981525 2982556 + hypothetical protein gene gene-HME7025_02550 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02550 HME7025_02551 HME7025_02551 HME7025_02551 2982559 2982954 - hypothetical protein gene gene-HME7025_02551 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02551 HME7025_02552 HME7025_02552 HME7025_02552 2982958 2983842 - Pirin-like protein Belongs to the pirin family gene gene-HME7025_02552 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02552 HME7025_02553 HME7025_02553 HME7025_02553 2983903 2984115 + hypothetical protein gene gene-HME7025_02553 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02553 HME7025_02554 HME7025_02554 HME7025_02554 2984189 2987449 + TonB-dependent receptor SusC Carbohydrate metabolism%3B Cell outer membrane%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation%3B Belongs to the TonB-dependent receptor family gene gene-HME7025_02554 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02554 HME7025_02555 HME7025_02555 HME7025_02555 2987514 2989283 + hypothetical protein gene gene-HME7025_02555 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02555 HME7025_02556 HME7025_02556 HME7025_02556 2989612 2990508 + hypothetical protein gene gene-HME7025_02556 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02556 HME7025_02557 HME7025_02557 HME7025_02557 2990821 2992503 + hypothetical protein gene gene-HME7025_02557 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02557 HME7025_02558 HME7025_02558 HME7025_02558 2992514 2993821 - putative transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the major facilitator superfamily gene gene-HME7025_02558 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02558 HME7025_02559 HME7025_02559 HME7025_02559 2993831 2994286 - hypothetical protein gene gene-HME7025_02559 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02559 HME7025_02560 HME7025_02560 HME7025_02560 2994298 2995143 - Putative arsenite methyltransferase Arsenical resistance%3B Plasmid%3B S-adenosyl-L-methionine%3B Transferase.%3B Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals%3B Belongs to the methyltransferase superfamily gene gene-HME7025_02560 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02560 HME7025_02561 HME7025_02561 HME7025_02561 2995197 2995619 - hypothetical protein gene gene-HME7025_02561 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02561 HME7025_02562 HME7025_02562 HME7025_02562 2995686 2996210 + hypothetical protein gene gene-HME7025_02562 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02562 HME7025_02563 HME7025_02563 HME7025_02563 2996285 2997172 + hypothetical protein gene gene-HME7025_02563 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02563 HME7025_02564 HME7025_02564 HME7025_02564 2997186 2998721 + hypothetical protein gene gene-HME7025_02564 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02564 HME7025_02565 HME7025_02565 HME7025_02565 2998810 3001221 - hypothetical protein gene gene-HME7025_02565 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02565 HME7025_02566 HME7025_02566 HME7025_02566 3001306 3003825 - Calcium-transporting ATPase ATP-binding%3B Calcium%3B Calcium transport%3B Golgi apparatus%3B Hydrolase%3B Ion transport%3B Magnesium%3B Membrane%3B Metal-binding%3B Nucleotide-binding%3B Phosphoprotein%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IIA subfamily%3B KEGG: samy:DB32_007374 Ca2+-transporting ATPase gene gene-HME7025_02566 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02566 HME7025_02567 HME7025_02567 HME7025_02567 3003822 3003929 - hypothetical protein gene gene-HME7025_02567 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02567 HME7025_02568 HME7025_02568 HME7025_02568 3004012 3004503 + hypothetical protein gene gene-HME7025_02568 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02568 HME7025_02569 HME7025_02569 ubiG ubiG 3004566 3005408 + 2-polyprenyl-6-hydroxyphenol methylase KEGG: ppu:PP_3629 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase gene gene-HME7025_02569 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02569 HME7025_02570 HME7025_02570 HME7025_02570 3005409 3006692 - putative galactarate transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Uptake of D-galactarate%3B Belongs to the major facilitator superfamily. Phthalate permease family gene gene-HME7025_02570 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02570 HME7025_02571 HME7025_02571 HME7025_02571 3006692 3007450 - Gluconate 5-dehydrogenase Lipid metabolism%3B NAD%3B Oxidoreductase%3B Steroid metabolism.%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: rle:RL2835 gluconate 5-dehydrogenase gene gene-HME7025_02571 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02571 HME7025_02572 HME7025_02572 HME7025_02572 3007465 3008646 - Mannonate dehydratase Iron%3B Lyase%3B Manganese.%3B Catalyzes the dehydration of D-mannonate%3B Belongs to the mannonate dehydratase family%3B KEGG: ttu:TERTU_0111 mannonate dehydratase gene gene-HME7025_02572 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02572 HME7025_02573 HME7025_02573 HME7025_02573 3008868 3010022 + HTH-type transcriptional regulator DegA Activator%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation.%3B Involved in the control of degradation of B. subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease. Contains 1 HTH lacI-type DNA-binding domain gene gene-HME7025_02573 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02573 HME7025_02574 HME7025_02574 HME7025_02574 3010019 3010897 - Endo-1%2C4-beta-xylanase KEGG: rba:RB3550 endo-1%2C4-beta-xylanase gene gene-HME7025_02574 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02574 HME7025_02575 HME7025_02575 HME7025_02575 3010905 3011906 - hypothetical protein gene gene-HME7025_02575 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02575 HME7025_02576 HME7025_02576 HME7025_02576 3011990 3012784 - Superoxide dismutase Acetylation%3B Manganese%3B Metal-binding%3B Mitochondrion%3B Nitration%3B Oxidoreductase%3B Transit peptide.%3B Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family%3B KEGG: hhy:Halhy_3829 superoxide dismutase%2C Fe-Mn family gene gene-HME7025_02576 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02576 HME7025_02577 HME7025_02577 HME7025_02577 3012926 3014089 - putative chromate transport protein Cell membrane%3B Chromate resistance%3B Membrane%3B Plasmid%3B Stress response%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B May function in the active transport of chromate into the cell under sulfur-deficient conditions. Belongs to the chromate ion transporter (CHR) (TC 2. A. 51) family gene gene-HME7025_02577 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02577 HME7025_02578 HME7025_02578 HME7025_02578 3014096 3014518 - hypothetical protein gene gene-HME7025_02578 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02578 HME7025_02579 HME7025_02579 HME7025_02579 3014600 3015859 - UPF0324 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix.%3B Belongs to the UPF0324 family gene gene-HME7025_02579 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02579 HME7025_02580 HME7025_02580 bglX bglX 3015930 3016898 + Beta-glucosidase KEGG: bvs:BARVI_10635 beta-glucosidase gene gene-HME7025_02580 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02580 HME7025_02581 HME7025_02581 HME7025_02581 3016909 3017310 + hypothetical protein gene gene-HME7025_02581 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02581 HME7025_02582 HME7025_02582 HME7025_02582 3017307 3017771 - Carbonate dehydratase Acyltransferase%3B Transferase.%3B Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers L-threonine%2C L-serine and L-methionine. It can also use O-acetyl-L-serine%2C L-tryptophan%2C L- isoleucine%2C L-valine%2C L-homoserine%2C 7-aminocephalosporanic acid%2C thiamine pyrophosphate and thiamine%3B Contains 1 N-acetyltransferase domain%3B KEGG: aza:AZKH_0511 carbonic anhydrase gene gene-HME7025_02582 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02582 HME7025_02583 HME7025_02583 HME7025_02583 3017771 3018217 - hypothetical protein gene gene-HME7025_02583 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02583 HME7025_02584 HME7025_02584 HME7025_02584 3018334 3019398 + hypothetical protein gene gene-HME7025_02584 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02584 HME7025_02585 HME7025_02585 HME7025_02585 3019513 3021003 + hypothetical protein gene gene-HME7025_02585 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02585 HME7025_02586 HME7025_02586 HME7025_02586 3021175 3021810 + hypothetical protein gene gene-HME7025_02586 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02586 HME7025_02587 HME7025_02587 HME7025_02587 3021829 3024687 + Nitrite reductase (NO-forming) KEGG: put:PT7_1499 nitrite reductase (NO-forming) gene gene-HME7025_02587 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02587 HME7025_02588 HME7025_02588 HME7025_02588 3024695 3025876 + hypothetical protein gene gene-HME7025_02588 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02588 HME7025_02589 HME7025_02589 HME7025_02589 3025890 3026297 - 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase Acyltransferase%3B Transferase.%3B Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: nko:Niako_0365 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase gene gene-HME7025_02589 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02589 HME7025_02590 HME7025_02590 HME7025_02590 3026303 3028396 - Quinoprotein glucose dehydrogenase (PQQ%2C quinone) Calcium%3B Cell membrane%3B Disulfide bond%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B PQQ%3B Pyrrolidone carboxylic acid%3B Signal.%3B Catalyzes the oxidation of primary alcohols except for methanol that is not a substrate%3B Belongs to the bacterial PQQ dehydrogenase family%3B Contains 1 cytochrome c domain%3B KEGG: sli:Slin_1132 quinoprotein glucose dehydrogenase gene gene-HME7025_02590 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02590 HME7025_02591 HME7025_02591 HME7025_02591 3028777 3029103 + hypothetical protein gene gene-HME7025_02591 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02591 HME7025_02592 HME7025_02592 HME7025_02592 3029093 3030391 + DNA (cytosine-5-)-methyltransferase Methyltransferase%3B Restriction system%3B S-adenosyl-L-methionine%3B Transferase.%3B This methylase recognizes the double-stranded sequence GATC%2C causes specific methylation on C-4 on both strands and protects the DNA from cleavage by the Sau3AI endonuclease. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family%3B Contains 1 SAM-dependent MTase C5-type domain%3B KEGG: fps:FP0736 DNA (cytosine-5)-methyltransferase 1 gene gene-HME7025_02592 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02592 HME7025_02593 HME7025_02593 HME7025_02593 3030363 3031748 + Type-2 restriction enzyme Sau3AI Endonuclease%3B Hydrolase%3B Magnesium%3B Nuclease%3B Restriction system. gene gene-HME7025_02593 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02593 HME7025_02594 HME7025_02594 HME7025_02594 3032033 3032563 + hypothetical protein gene gene-HME7025_02594 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02594 HME7025_02595 HME7025_02595 HME7025_02595 3032760 3035519 + Nitrite reductase (NO-forming) KEGG: oce:GU3_12660 nitrite reductase (NO-forming) gene gene-HME7025_02595 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02595 HME7025_02596 HME7025_02596 HME7025_02596 3035594 3036007 - hypothetical protein gene gene-HME7025_02596 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02596 HME7025_02597 HME7025_02597 HME7025_02597 3036131 3039751 - Alpha-L-rhamnosidase KEGG: eol:Emtol_2273 alpha-L-rhamnosidase gene gene-HME7025_02597 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02597 HME7025_02598 HME7025_02598 dpkA dpkA 3040312 3041340 + 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) Cytoplasm%3B NAD%3B Oxidoreductase.%3B Catalyzes the reduction of 2%2C3-diketo-L-gulonate in the presence of NADH%2C to form 3-keto-L-gulonate%3B Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily%3B KEGG: psyr:N018_10045 delta1-piperideine-2-carboxylate reductase gene gene-HME7025_02598 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02598 HME7025_02599 HME7025_02599 HME7025_02599 3041422 3042537 - hypothetical protein gene gene-HME7025_02599 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02599 HME7025_02600 HME7025_02600 HME7025_02600 3042548 3043732 - Histidinol-phosphate transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Histidine biosynthesis%3B Pyridoxal phosphate%3B Transferase.%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily%3B KEGG: dfe:Dfer_2627 histidinol-phosphate aminotransferase gene gene-HME7025_02600 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02600 HME7025_02601 HME7025_02601 HME7025_02601 3043872 3043976 + hypothetical protein gene gene-HME7025_02601 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02601 HME7025_02602 HME7025_02602 HME7025_02602 3044382 3045965 - hypothetical protein gene gene-HME7025_02602 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02602 HME7025_02603 HME7025_02603 HME7025_02603 3045955 3046326 - hypothetical protein gene gene-HME7025_02603 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02603 HME7025_02604 HME7025_02604 HME7025_02604 3046500 3047876 - Inositol 2-dehydrogenase Oxidoreductase.%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: bge:BC1002_2041 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_02604 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02604 HME7025_02605 HME7025_02605 HME7025_02605 3047873 3049033 - hypothetical protein gene gene-HME7025_02605 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02605 HME7025_02606 HME7025_02606 HME7025_02606 3049194 3049607 - Peroxiredoxin OsmC Acetylation%3B Antioxidant%3B Cytoplasm%3B Oxidoreductase%3B Peroxidase.%3B Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide%3B Belongs to the OsmC/Ohr family gene gene-HME7025_02606 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02606 HME7025_02607 HME7025_02607 HME7025_02607 3049752 3050054 - hypothetical protein gene gene-HME7025_02607 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02607 HME7025_02608 HME7025_02608 HME7025_02608 3050111 3051796 - hypothetical protein gene gene-HME7025_02608 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02608 HME7025_02609 HME7025_02609 HME7025_02609 3051853 3052311 - hypothetical protein gene gene-HME7025_02609 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02609 HME7025_02610 HME7025_02610 HME7025_02610 3052308 3052871 - hypothetical protein gene gene-HME7025_02610 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02610 HME7025_02611 HME7025_02611 HME7025_02611 3052949 3053668 - 8-oxo-dGTP diphosphatase KEGG: nko:Niako_5885 8-oxo-dGTP diphosphatase gene gene-HME7025_02611 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02611 HME7025_02612 HME7025_02612 HME7025_02612 3053866 3055476 + Acetylcholinesterase Alternative splicing%3B Cell junction%3B Cell membrane%3B Disulfide bond%3B Glycoprotein%3B GPI-anchor%3B Hydrolase%3B Lipoprotein%3B Membrane%3B Neurotransmitter degradation%3B Secreted%3B Serine esterase%3B Signal%3B Synapse.%3B Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Belongs to the type-B carboxylesterase/lipase family%3B KEGG: eol:Emtol_3172 para-nitrobenzyl esterase%3B Carboxylic ester hydrolases gene gene-HME7025_02612 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02612 HME7025_02613 HME7025_02613 phzF phzF 3055602 3056387 + Trans-2%2C3-dihydro-3-hydroxyanthranilate isomerase Isomerase.%3B Belongs to the PhzF family%3B KEGG: syn:slr1019 trans-2%2C3-dihydro-3-hydroxyanthranilate isomerase gene gene-HME7025_02613 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02613 HME7025_02614 HME7025_02614 HME7025_02614 3056444 3057304 - hypothetical protein gene gene-HME7025_02614 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02614 HME7025_02615 HME7025_02615 HME7025_02615 3057423 3057959 - hypothetical protein gene gene-HME7025_02615 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02615 HME7025_02616 HME7025_02616 HME7025_02616 3057974 3058900 - hypothetical protein gene gene-HME7025_02616 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02616 HME7025_02617 HME7025_02617 HME7025_02617 3059013 3059597 - Potassium channel Ion channel%3B Ion transport%3B Membrane%3B Potassium%3B Potassium channel%3B Potassium transport%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Potassium channel%3B Belongs to the TMEM175 family gene gene-HME7025_02617 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02617 HME7025_02618 HME7025_02618 HME7025_02618 3059635 3060510 - hypothetical protein gene gene-HME7025_02618 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02618 HME7025_02619 HME7025_02619 HME7025_02619 3060714 3061916 + Multidrug resistance protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Multidrug resistance pump that participates in a low energy shock adaptive response. Belongs to the major facilitator superfamily gene gene-HME7025_02619 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02619 HME7025_02620 HME7025_02620 HME7025_02620 3061943 3062623 - hypothetical protein gene gene-HME7025_02620 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02620 HME7025_02621 HME7025_02621 HME7025_02621 3062730 3064379 + putative ABC transporter ATP-binding protein ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport.%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene-HME7025_02621 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02621 HME7025_02622 HME7025_02622 HME7025_02622 3064381 3065694 + hypothetical protein gene gene-HME7025_02622 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02622 HME7025_02623 HME7025_02623 HME7025_02623 3065684 3067069 + hypothetical protein gene gene-HME7025_02623 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02623 HME7025_02624 HME7025_02624 HME7025_02624 3067119 3067325 - putative HTH-type transcriptional regulator YozG DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH cro/C1-type DNA-binding domain gene gene-HME7025_02624 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02624 HME7025_02625 HME7025_02625 HME7025_02625 3067328 3067840 - hypothetical protein gene gene-HME7025_02625 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02625 HME7025_02626 HME7025_02626 HME7025_02626 3067957 3068190 - hypothetical protein gene gene-HME7025_02626 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02626 HME7025_02627 HME7025_02627 HME7025_02627 3068248 3070422 + Vitamin B12 transporter BtuB Cell outer membrane%3B Ion transport%3B Membrane%3B Porin%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport.%3B Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB%3B Belongs to the TonB-dependent receptor family. BtuB (TC 1. B. 14. 3. 1) subfamily gene gene-HME7025_02627 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02627 HME7025_02628 HME7025_02628 HME7025_02628 3070428 3071549 - hypothetical protein gene gene-HME7025_02628 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02628 HME7025_02629 HME7025_02629 HME7025_02629 3071546 3071842 - uncharacterized protein Contains 1 ABM domain gene gene-HME7025_02629 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02629 HME7025_02630 HME7025_02630 HME7025_02630 3071861 3072439 - hypothetical protein gene gene-HME7025_02630 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02630 HME7025_02631 HME7025_02631 HME7025_02631 3072476 3072826 - hypothetical protein gene gene-HME7025_02631 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02631 HME7025_02632 HME7025_02632 HME7025_02632 3072947 3073354 + hypothetical protein gene gene-HME7025_02632 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02632 HME7025_02633 HME7025_02633 HME7025_02633 3073409 3074059 + hypothetical protein gene gene-HME7025_02633 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02633 HME7025_02634 HME7025_02634 HME7025_02634 3074127 3075122 - hypothetical protein gene gene-HME7025_02634 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02634 HME7025_02635 HME7025_02635 HME7025_02635 3075187 3076608 - Adenosine deaminase KEGG: salu:DC74_1368 adenosine deaminase gene gene-HME7025_02635 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02635 HME7025_02636 HME7025_02636 HME7025_02636 3076725 3077123 + hypothetical protein gene gene-HME7025_02636 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02636 HME7025_02637 HME7025_02637 HME7025_02637 3077120 3077755 - hypothetical protein gene gene-HME7025_02637 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02637 HME7025_02638 HME7025_02638 HME7025_02638 3077938 3079050 + N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D Signal.%3B To K. pneumoniae RomA%3B KEGG: gsl:Gasu_61510 N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D gene gene-HME7025_02638 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02638 HME7025_02639 HME7025_02639 HME7025_02639 3079232 3080479 + hypothetical protein gene gene-HME7025_02639 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02639 HME7025_02640 HME7025_02640 HME7025_02640 3080550 3081542 - hypothetical protein gene gene-HME7025_02640 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02640 HME7025_02641 HME7025_02641 HME7025_02641 3081547 3082677 - Carbohydrate acetyl esterase/feruloyl esterase Carbohydrate metabolism%3B Hydrolase%3B Multifunctional enzyme%3B Polysaccharide degradation%3B Signal%3B Xylan degradation.%3B Involved in degradation of plant cell wall polysaccharides. Bifunctional esterase that possesses both acetyl esterase and ferulic acid esterase activities. Has deacetylase activity towards acetylated xylo-oligosaccharides smaller than xylo-heptaose%2C as well as from glucose-pentaacetate. Is also able to release ferulic acid from methylferulate%2C and from the more natural substrates wheat bran%2C corn fiber%2C and XOS(FA%2CAc)%2C a corn fiber-derived substrate enriched in O-acetyl and ferulic acid esters%3B In the N-terminal sectio%3B belongs to the carbohydrate esterase 6 family gene gene-HME7025_02641 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02641 HME7025_02642 HME7025_02642 HME7025_02642 3082892 3084922 + Beta-glucosidase Carbohydrate metabolism%3B Glycosidase%3B Hydrolase%3B Multifunctional enzyme%3B Periplasm%3B Polysaccharide degradation%3B Signal%3B Xylan degradation.%3B Exhibits both beta-glucosidase and beta-xylosidase activities. Belongs to the glycosyl hydrolase 3 family%3B KEGG: eol:Emtol_2121 beta-glucosidase gene gene-HME7025_02642 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02642 HME7025_02643 HME7025_02643 HME7025_02643 3085018 3085656 + uncharacterized protein gene gene-HME7025_02643 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02643 HME7025_02644 HME7025_02644 HME7025_02644 3085660 3086586 - putative HTH-type transcriptional regulator YijO DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene-HME7025_02644 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02644 HME7025_02645 HME7025_02645 HME7025_02645 3086680 3087447 + hypothetical protein gene gene-HME7025_02645 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02645 HME7025_02646 HME7025_02646 HME7025_02646 3087500 3088261 + hypothetical protein gene gene-HME7025_02646 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02646 HME7025_02647 HME7025_02647 HME7025_02647 3088258 3089226 - AB hydrolase superfamily protein Cytoplasm%3B Hydrolase%3B Nucleus.%3B Belongs to the AB hydrolase superfamily%3B KEGG: cbw:RR42_m4101 acetyl esterase%3B Carboxylic ester hydrolases gene gene-HME7025_02647 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02647 HME7025_02648 HME7025_02648 HME7025_02648 3089299 3091533 - Isoquinoline 1-oxidoreductase Oxidoreductase.%3B KEGG: eol:Emtol_0260 isoquinoline 1-oxidoreductase%2C beta subunit gene gene-HME7025_02648 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02648 HME7025_02649 HME7025_02649 HME7025_02649 3091535 3091996 - Isoquinoline 1-oxidoreductase 2Fe-2S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase.%3B Specific towards N-containing N-heterocyclic substrates%2C including isoquinoline%2C isoquinolin-5-ol%2C phthalazine and quinazoline. Contains 1 2Fe-2S ferredoxin-type domain%3B KEGG: sli:Slin_6243 isoquinoline 1-oxidoreductase%2C alpha subunit gene gene-HME7025_02649 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02649 HME7025_02650 HME7025_02650 HME7025_02650 3092073 3092921 - 2%2C5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) NADP%3B Oxidoreductase.%3B Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis%3B Belongs to the aldo/keto reductase family%3B KEGG: rah:Rahaq_0977 2%2C5-diketo-D-gluconate reductase A gene gene-HME7025_02650 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02650 HME7025_02651 HME7025_02651 HME7025_02651 3092931 3093845 - hypothetical protein gene gene-HME7025_02651 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02651 HME7025_02652 HME7025_02652 HME7025_02652 3094013 3094465 + hypothetical protein gene gene-HME7025_02652 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02652 HME7025_02653 HME7025_02653 HME7025_02653 3094629 3096863 + Isoquinoline 1-oxidoreductase Oxidoreductase.%3B KEGG: tmo:TMO_b0195 isoquinoline 1-oxidoreductase%2C beta subunit gene gene-HME7025_02653 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02653 HME7025_02654 HME7025_02654 HME7025_02654 3096957 3097589 - hypothetical protein gene gene-HME7025_02654 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02654 HME7025_02655 HME7025_02655 HME7025_02655 3097699 3097995 + putative HTH-type transcriptional regulator YdeP DNA-binding%3B Transcription%3B Transcription regulation.%3B Contains 1 HTH hxlR-type DNA-binding domain gene gene-HME7025_02655 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02655 HME7025_02656 HME7025_02656 HME7025_02656 3098062 3099636 + Fumonisin B1 esterase Hydrolase.%3B Involved in degradation of fumonisin B1. Catalyzes the hydrolysis of fumonisin B1 (FB1) to aminopentol (HFB1)%3B Belongs to the type-B carboxylesterase/lipase family%3B KEGG: bja:bll4001 para-nitrobenzyl esterase%3B Carboxylic ester hydrolases gene gene-HME7025_02656 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02656 HME7025_02657 HME7025_02657 HME7025_02657 3099834 3100091 + hypothetical protein gene gene-HME7025_02657 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02657 HME7025_02658 HME7025_02658 HME7025_02658 3100098 3101303 + hypothetical protein gene gene-HME7025_02658 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02658 HME7025_02659 HME7025_02659 HME7025_02659 3101317 3101751 + hypothetical protein gene gene-HME7025_02659 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02659 HME7025_02660 HME7025_02660 HME7025_02660 3101816 3102175 + hypothetical protein gene gene-HME7025_02660 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02660 HME7025_02661 HME7025_02661 HME7025_02661 3102175 3102930 + hypothetical protein gene gene-HME7025_02661 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02661 HME7025_02662 HME7025_02662 HME7025_02662 3102923 3104419 - Plipastatin synthase subunit Antibiotic biosynthesis%3B Multifunctional enzyme%3B Phosphopantetheine%3B Phosphoprotein%3B Repeat%3B Transferase.%3B This protein is a multifunctional enzyme%2C able to activate and polymerize the amino acids Pro%2C Gln and Tyr as part of the biosynthesis of the lipopeptide antibiotic plipastatin. The Tyr residue is further epimerized to the D-isomer form. The activation sites for these amino acids consist of individual domains%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B Contains 3 acyl carrier domains%3B KEGG: isc:IscW_ISCW014871 malonyl-CoA/methylmalonyl-CoA synthetase%3B Acid--thiol ligases gene gene-HME7025_02662 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02662 HME7025_02663 HME7025_02663 HME7025_02663 3104541 3105392 - hypothetical protein gene gene-HME7025_02663 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02663 HME7025_02664 HME7025_02664 HME7025_02664 3105392 3106363 - hypothetical protein gene gene-HME7025_02664 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02664 HME7025_02665 HME7025_02665 HME7025_02665 3106377 3106541 - hypothetical protein gene gene-HME7025_02665 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02665 HME7025_02666 HME7025_02666 HME7025_02666 3106632 3107543 + putative RuBisCO transcriptional regulator DNA-binding%3B Transcription%3B Transcription regulation.%3B Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene-HME7025_02666 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02666 HME7025_02667 HME7025_02667 HME7025_02667 3107867 3108742 + Endo-1%2C4-beta-xylanase/feruloyl esterase Carbohydrate metabolism%3B Glycosidase%3B Hydrolase%3B Multifunctional enzyme%3B Polysaccharide degradation%3B Signal%3B Xylan degradation.%3B Involved in degradation of plant cell wall polysaccharides. Has endo-xylanase activity towards substrates such as oat spelt xylan (OSX)%2C acetylated xylo-oligosaccharides and acetylated xylan%2C producing primarily xylobios%3B can not hydrolyze xylobiose to xylose. Also has feruloyl esterase activity%2C releasing ferulic acid from methylferulate%2C and from the more natural substrates wheat bran%2C corn fiber%2C and XOS(FA%2CAc)%2C a corn fiber-derived substrate enriched in O-acetyl and ferulic acid esters. Exhibits negligible acetyl esterase activity on sugar acetates. Acts synergistically with Xyl3A to increase the release of xylose from xylan. Does not possess endoglucanase or mannanase activities since it is not able to hydrolyze carboxymethyl cellulose and locust bean gum%3B In the N-terminal sectio%3B belongs to the glycosyl hydrolase 10 (cellulase F) family%3B Contains 1 GH10 (glycosyl hydrolase family 10) domain gene gene-HME7025_02667 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02667 HME7025_02668 HME7025_02668 HME7025_02668 3108930 3110330 - Inositol 2-dehydrogenase NAD%3B Oxidoreductase.%3B Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI)%2C respectively%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: wic:J056_003487 myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase gene gene-HME7025_02668 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02668 HME7025_02669 HME7025_02669 HME7025_02669 3110352 3111308 - uncharacterized protein Belongs to the TolB family gene gene-HME7025_02669 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02669 HME7025_02670 HME7025_02670 HME7025_02670 3111449 3112174 + 8-oxo-dGTP diphosphatase KEGG: scu:SCE1572_14140 8-oxo-dGTP diphosphatase gene gene-HME7025_02670 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02670 HME7025_02671 HME7025_02671 HME7025_02671 3112539 3113690 + uncharacterized protein gene gene-HME7025_02671 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02671 HME7025_02672 HME7025_02672 HME7025_02672 3113723 3114871 + uncharacterized protein gene gene-HME7025_02672 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02672 HME7025_02673 HME7025_02673 HME7025_02673 3114944 3115246 - hypothetical protein gene gene-HME7025_02673 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02673 HME7025_02674 HME7025_02674 HME7025_02674 3115370 3116287 + hypothetical protein gene gene-HME7025_02674 http://www.ncbi.nlm.nih.gov/gene/?term=HME7025_02674