locus-tag class description OJF2_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) OJF2_00020 ENOG4105C0H protease OJF2_00050 ENOG41061MV Arylsulfatase OJF2_00140 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_00190 ENOG4107VGF ig domain protein group 2 domain protein OJF2_00210 ENOG4105D9P serine threonine protein kinase OJF2_00250 ENOG4105D9P serine threonine protein kinase OJF2_00260 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) OJF2_00280 ENOG4108DMA Nad-dependent epimerase dehydratase OJF2_00290 ENOG4105DU6 RNA polymerase OJF2_00310 ENOG4105DET Rhamnulokinase OJF2_00350 ENOG41061TZ Short-chain dehydrogenase reductase Sdr OJF2_00400 ENOG4105BZU Histidine kinase OJF2_00490 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) OJF2_00520 ENOG4105C1B dTDP-glucose 4-6-dehydratase OJF2_00530 ENOG4107QQG Dehydrogenase OJF2_00580 ENOG4105ETX regulatoR OJF2_00600 ENOG4105BZU Histidine kinase OJF2_00670 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) OJF2_00780 ENOG4108YYH Nadph-dependent fmn reductase OJF2_00800 ENOG4105T0Z Conserved Protein OJF2_00820 ENOG4105D64 Mechanosensitive ion channel OJF2_00830 ENOG41082BM Transcriptional regulator, arsr family OJF2_00860 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) OJF2_00920 ENOG4105C3J Cysteine desulfurase OJF2_00980 ENOG4105NA0 Transcriptional regulator OJF2_01040 ENOG4105D9P serine threonine protein kinase OJF2_01090 ENOG4105D9P serine threonine protein kinase OJF2_01170 ENOG4106FGB Beta-lactamase OJF2_01180 ENOG4107WEA mandelate racemase muconate lactonizing OJF2_01190 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate OJF2_01200 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein OJF2_01240 ENOG4105C1P efflux transporter, rnd family, mfp subunit OJF2_01400 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) OJF2_01410 ENOG4107YTP response regulator receiver protein OJF2_01420 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) OJF2_01560 ENOG4108V5V Serine Threonine protein kinase OJF2_01570 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) OJF2_01600 ENOG4105ESV Glycosyl transferase, family 4 OJF2_01610 ENOG4107YJ4 chain length determinant protein OJF2_01660 ENOG4105C0K Gdp-mannose 4,6-dehydratase OJF2_01700 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) OJF2_01720 ENOG4108KQ5 Integrase catalytic subunit OJF2_01730 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain OJF2_01830 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) OJF2_01910 ENOG410645S MarR family Transcriptional regulator OJF2_01990 ENOG4105MP9 class II Aldolase OJF2_02010 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) OJF2_02020 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) OJF2_02030 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) OJF2_02040 ENOG4105QAX Iron-sulfur OJF2_02090 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) OJF2_02220 ENOG4105VT3 DNA binding domain protein, excisionase family OJF2_02310 ENOG410624X efflux transporter, rnd family, mfp subunit OJF2_02380 ENOG41061MV Arylsulfatase OJF2_02430 ENOG4105D9P serine threonine protein kinase OJF2_02450 ENOG4105CBS Chea signal transduction histidine kinase OJF2_02460 ENOG4105BZU Histidine kinase OJF2_02470 ENOG4105C8Q Methyl-accepting chemotaxis OJF2_02480 ENOG4108V3W Chemotaxis protein, CheW OJF2_02540 ENOG4105NTD Inherit from COG: Hydrolase OJF2_02560 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) OJF2_02600 ENOG4105C6Y Udp-glucose 6-dehydrogenase OJF2_02710 ENOG4105C0D helicase OJF2_02720 ENOG4107VUZ OJF2_02740 ENOG4107P5I polyketide synthase OJF2_02800 ENOG4105VPX protein, conserved in bacteria OJF2_02860 ENOG4105D9P serine threonine protein kinase OJF2_02950 ENOG4105BZ8 glutamate synthase OJF2_02990 ENOG4105C7S Dehydrogenase OJF2_03030 ENOG4105EMU Dehydrogenase OJF2_03060 ENOG4108TGP Thioesterase superfamily protein OJF2_03070 ENOG4107QSA Oxaloacetate decarboxylase OJF2_03080 ENOG4107QX3 carboxylase OJF2_03110 ENOG4108ZVT methylmalonyl-coA epimerase OJF2_03140 ENOG4105E33 succinate dehydrogenase OJF2_03170 ENOG4108V5V Serine Threonine protein kinase OJF2_03230 ENOG4108MR6 WD40-like Beta Propeller Repeat OJF2_03280 ENOG4108JUA Transcriptional regulator OJF2_03290 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein OJF2_03300 ENOG4108I5D sulfate abc transporter OJF2_03320 ENOG4108IJ6 ABC transporter OJF2_03360 ENOG4105C26 Dehydrogenase OJF2_03370 ENOG4105CPC Aldo Keto reductase OJF2_03410 ENOG4105CD5 CoA-binding domain protein OJF2_03420 ENOG4105DU6 RNA polymerase OJF2_03450 ENOG4105GTG Isochorismatase OJF2_03530 ENOG4108VX5 3-methyladenine DNA glycosylase OJF2_03540 ENOG4105D9P serine threonine protein kinase OJF2_03580 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein OJF2_03590 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer OJF2_03610 ENOG4108V3W Chemotaxis protein, CheW OJF2_03620 ENOG4108KTQ Methyltransferase OJF2_03640 ENOG4105CBS Chea signal transduction histidine kinase OJF2_03660 ENOG4105DSF transport protein OJF2_03670 ENOG4105D9P serine threonine protein kinase OJF2_03740 ENOG4108UK5 Transposase OJF2_03860 ENOG4105K6V RNA polymerase OJF2_03900 ENOG4105K64 Glycosyl transferase, family 2 OJF2_03940 ENOG4108MJI response regulator OJF2_03950 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) OJF2_04060 ENOG4105T16 Transcriptional regulator (AraC family) OJF2_04210 ENOG4105NAF rna polymerase sigma factor OJF2_04220 ENOG4108PBA serine threonine protein kinase OJF2_04250 ENOG4105E18 UPF0276 protein OJF2_04280 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family OJF2_04290 ENOG4105CAQ asparagine synthetase OJF2_04300 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) OJF2_04360 ENOG4105EXC Acyl-transferase OJF2_04380 ENOG4105DDI hemolysin-type calcium-binding region OJF2_04440 ENOG4105DWV Homoserine O-trans-acetylase OJF2_04470 ENOG4107QHQ amino acid OJF2_04530 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) OJF2_04550 ENOG4105FFC UPF0187 protein OJF2_04560 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) OJF2_04580 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) OJF2_04650 ENOG4105EMN RNA polymerase sigma factor OJF2_04700 ENOG4105CSV Glutaminase OJF2_04730 ENOG4105DHU Bile acid OJF2_04760 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) OJF2_04770 ENOG4107T8Q Glycosyl transferase (Group 1 OJF2_04780 ENOG4108KMV Glycosyl transferase (Group 1 OJF2_04790 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein OJF2_04830 ENOG4105D9P serine threonine protein kinase OJF2_04870 ENOG4105DU6 RNA polymerase OJF2_04880 ENOG4105EIE fructose-bisphosphate aldolase OJF2_04920 ENOG4105WH1 Two component transcriptional regulator luxr family OJF2_04950 ENOG4105WH1 Two component transcriptional regulator luxr family OJF2_05080 ENOG4105D2M Aldolase OJF2_05100 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase OJF2_05110 ENOG4105C2X Arabinose 5-phosphate isomerase OJF2_05150 ENOG4108KDT Molybdate metabolism regulator OJF2_05290 ENOG4107QPV Serine Threonine protein kinase OJF2_05300 ENOG4105D9P serine threonine protein kinase OJF2_05380 ENOG4107TVC Glycosyl transferase, family 2 OJF2_05410 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) OJF2_05420 ENOG4105CPK Glycosyl transferase (Group 1 OJF2_05440 ENOG4105FB9 CRISPR-associated protein OJF2_05480 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) OJF2_05490 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) OJF2_05800 ENOG4108F3G Type I restriction-modification system, R subunit OJF2_05950 ENOG4105DU6 RNA polymerase OJF2_05980 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_06080 ENOG4105NPQ Pfam:DUF403 OJF2_06100 ENOG4105X54 addiction module antidote protein OJF2_06120 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP OJF2_06160 ENOG4105BZU Histidine kinase OJF2_06220 ENOG4107QPV Serine Threonine protein kinase OJF2_06230 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) OJF2_06370 ENOG4105EMN RNA polymerase sigma factor OJF2_06390 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) OJF2_06410 ENOG4105CTM Glycoside hydrolase family 5 OJF2_06430 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) OJF2_06450 ENOG4105D9P serine threonine protein kinase OJF2_06470 ENOG4107S1E Beta-lactamase OJF2_06530 ENOG4105K59 histidine triad (HIT) protein OJF2_06540 ENOG4108ZT0 50S ribosomal protein l17 OJF2_06550 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) OJF2_06560 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) OJF2_06570 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) OJF2_06580 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits OJF2_06590 ENOG41067V7 50S ribosomal protein L36 OJF2_06660 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) OJF2_06670 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) OJF2_06680 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) OJF2_06690 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) OJF2_06700 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) OJF2_06710 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) OJF2_06720 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) OJF2_06730 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) OJF2_06740 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits OJF2_06750 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) OJF2_06760 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) OJF2_06770 ENOG41084D8 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal OJF2_06780 ENOG41087TA 50s ribosomal protein l29 OJF2_06790 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) OJF2_06800 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) OJF2_06810 ENOG4108063 its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) OJF2_06820 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) OJF2_06830 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity OJF2_06840 ENOG410855W One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) OJF2_06850 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) OJF2_06860 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) OJF2_06870 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) OJF2_07010 ENOG4107QPV Serine Threonine protein kinase OJF2_07020 ENOG4108R1E Serine threonine protein phosphatase 1 OJF2_07080 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) OJF2_07120 ENOG4105D9P serine threonine protein kinase OJF2_07140 ENOG4105D9P serine threonine protein kinase OJF2_07160 ENOG4105KVH Transcriptional regulator OJF2_07180 ENOG4108XFH Transcriptional regulator OJF2_07190 ENOG4105DQ4 alcohol dehydrogenase OJF2_07230 ENOG4105CPC Aldo Keto reductase OJF2_07300 ENOG4105D9P serine threonine protein kinase OJF2_07440 ENOG4105BZU Histidine kinase OJF2_07530 ENOG4105CGS Alpha-glucosidase OJF2_07590 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 OJF2_07660 ENOG4105D9P serine threonine protein kinase OJF2_07670 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_07680 ENOG4105DYC esterase OJF2_07730 ENOG4108R86 Transcriptional regulator OJF2_07750 ENOG4105CJ1 ABC, transporter OJF2_07760 ENOG4107QWP ABC-2 type transporter OJF2_07770 ENOG4107QWP ABC-2 type transporter OJF2_07810 ENOG4105D9P serine threonine protein kinase OJF2_07900 ENOG4105MHT Transcriptional regulator, ARSR family OJF2_07920 ENOG4107QPV Serine Threonine protein kinase OJF2_07960 ENOG41083PU Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) OJF2_07970 ENOG4105CHR reductase OJF2_07980 ENOG4107ZT5 Thiol disulfide interchange protein OJF2_08150 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) OJF2_08160 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase OJF2_08260 ENOG410838F Glycosyl transferase family 2 OJF2_08390 ENOG4107R3E Citrate transporter OJF2_08400 ENOG4105C2C drug resistance transporter, Bcr CflA OJF2_08420 ENOG4105BZU Histidine kinase OJF2_08430 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_08500 ENOG4105DU6 RNA polymerase OJF2_08550 ENOG4105DTD Dehydrogenase OJF2_08590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_08640 ENOG4108DT4 serine threonine protein kinase OJF2_08650 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase OJF2_08710 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) OJF2_08720 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) OJF2_08750 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase OJF2_08810 ENOG4107EF8 Glycosyl transferase (Group 1 OJF2_08880 ENOG4105FJR Lmbe family OJF2_08920 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) OJF2_08990 ENOG4105DU6 RNA polymerase OJF2_09030 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) OJF2_09090 ENOG4105CSA Coproporphyrinogen iii oxidase OJF2_09110 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) OJF2_09170 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family OJF2_09180 ENOG4105CIG ABC transporter OJF2_09240 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) OJF2_09260 ENOG4105CKD glutathione-regulated potassium-efflux system protein OJF2_09340 ENOG4105DU6 RNA polymerase OJF2_09360 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) OJF2_09370 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) OJF2_09380 ENOG4108VZM 50s ribosomal protein L10 OJF2_09390 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) OJF2_09400 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) OJF2_09410 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) OJF2_09440 ENOG41084ED 50S ribosomal protein L33 OJF2_09450 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) OJF2_09530 ENOG4105BZU Histidine kinase OJF2_09540 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) OJF2_09550 ENOG4105C8Q Methyl-accepting chemotaxis OJF2_09580 ENOG4105CBS Chea signal transduction histidine kinase OJF2_09710 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) OJF2_09720 ENOG4105CKK Glycosyl transferase, family 2 OJF2_09850 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) OJF2_09930 ENOG4108ZF3 Phosphatase OJF2_09940 ENOG4105C34 Pseudouridine synthase OJF2_10020 ENOG4105D9P serine threonine protein kinase OJF2_10050 ENOG4106UW1 Major Facilitator superfamily OJF2_10060 ENOG4108KP7 hydrolase OJF2_10080 ENOG4108IJ9 (ABC) transporter OJF2_10110 ENOG4105ENT Efflux transporter rnd family, mfp subunit OJF2_10160 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) OJF2_10200 ENOG4108HMN Caspase domain OJF2_10210 ENOG4108HMN Caspase domain OJF2_10290 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_10300 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_10320 ENOG4105BZU Histidine kinase OJF2_10450 ENOG4105ECY inositol monophosphatase OJF2_10480 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family OJF2_10560 ENOG4105XB6 Toxin coregulated pilin OJF2_10620 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) OJF2_10650 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_10740 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_10790 ENOG4105GRZ Ycii-related protein OJF2_10860 ENOG4105D07 Signal peptide peptidase, SppA OJF2_10920 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) OJF2_10930 ENOG4107FW0 short-chain dehydrogenase reductase OJF2_10950 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) OJF2_10960 ENOG4107RBB ABC transporter, permease OJF2_11000 ENOG4105BZU Histidine kinase OJF2_11050 ENOG4105KHC sulfurtransferase OJF2_11080 ENOG4105EGD dinuclear metal center protein, YbgI family OJF2_11090 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 OJF2_11110 ENOG4105ENT Efflux transporter rnd family, mfp subunit OJF2_11160 ENOG4105C9U ATP-dependent DNA helicase RecQ OJF2_11190 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) OJF2_11210 ENOG4105D9R oxidoreductase OJF2_11240 ENOG4105D9P serine threonine protein kinase OJF2_11320 ENOG4108KDT Molybdate metabolism regulator OJF2_11340 ENOG4105DEG Vwa containing coxe family protein OJF2_11360 ENOG4105KKX ATPase associated with various cellular activities aaa_5 OJF2_11370 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) OJF2_11380 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) OJF2_11390 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor OJF2_11400 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor OJF2_11410 ENOG4105D7Q type ii secretion system OJF2_11440 ENOG4105DMT epimerase dehydratase OJF2_11450 ENOG4105E6M Sulphatase-modifying factor protein OJF2_11460 ENOG4105CPC Aldo Keto reductase OJF2_11500 ENOG4105EGE secreted protein OJF2_11520 ENOG4105C1V Peptidase, M16 OJF2_11530 ENOG4105C1V Peptidase, M16 OJF2_11540 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) OJF2_11600 ENOG4105CEY Amp-dependent synthetase and ligase OJF2_11610 ENOG4108RE9 Phosphodiesterase OJF2_11620 ENOG4105CAQ asparagine synthetase OJF2_11670 ENOG4105C28 cystathionine OJF2_11690 ENOG4105D63 family UPF0324 OJF2_11710 ENOG4105CE1 Ferrous iron transport protein b OJF2_11750 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) OJF2_11850 ENOG4108RVA ribokinase OJF2_11860 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) OJF2_11880 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) OJF2_11890 ENOG4105CJT Mannose-1-phosphate guanylyltransferase OJF2_11930 ENOG4105D9P serine threonine protein kinase OJF2_11950 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) OJF2_11960 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) OJF2_11970 ENOG4105E08 Glycoside hydrolase, family 9 OJF2_12020 ENOG4105DJ4 phosphatidylserine decarboxylase OJF2_12050 ENOG4105EWI Short-chain dehydrogenase reductase Sdr OJF2_12080 ENOG4105DYC esterase OJF2_12100 ENOG4108XHQ (2Fe-2S)-binding domain protein OJF2_12110 ENOG4105C7W Xanthine dehydrogenase OJF2_12120 ENOG4108HR6 Dehydrogenase OJF2_12220 ENOG4105GRZ Ycii-related protein OJF2_12230 ENOG4105GRZ Ycii-related protein OJF2_12250 ENOG4105CP2 von willebrand factor, type a OJF2_12260 ENOG4105CHP RNA polymerase OJF2_12270 ENOG4105DIJ Phosphoethanolamine transferase OJF2_12350 ENOG41085EF Carbon storage regulator OJF2_12370 ENOG4108YZA Nitrogen regulatory protein pii OJF2_12410 ENOG4107X8Y Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity) OJF2_12420 ENOG4108SET Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) OJF2_12430 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) OJF2_12450 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH OJF2_12470 ENOG4108W2Y isochorismatase OJF2_12520 ENOG4105D9P serine threonine protein kinase OJF2_12560 ENOG4105P4J Allophanate hydrolase, subunit 1 OJF2_12670 ENOG4105KG3 cytidine deaminase OJF2_12680 ENOG4107QJE Chromosome Partitioning Protein OJF2_12710 ENOG4105DGU Histone deacetylase OJF2_12730 ENOG4107R7Y intracellular protease Pfpi family OJF2_12740 ENOG41084AE Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) OJF2_12780 ENOG4105CHR reductase OJF2_12790 ENOG4105D9P serine threonine protein kinase OJF2_12840 ENOG4105ESV Glycosyl transferase, family 4 OJF2_12860 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) OJF2_12880 ENOG4105C0H protease OJF2_12900 ENOG4105CJ1 ABC, transporter OJF2_12920 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) OJF2_12970 ENOG4105DPZ Two component transcriptional regulator (Winged helix family OJF2_12980 ENOG4105E5G Alpha beta hydrolase fold OJF2_12990 ENOG4105CRQ synthase (Component I) OJF2_13000 ENOG4107RGC Glycosyl transferase, family 2 OJF2_13020 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate OJF2_13030 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) OJF2_13050 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) OJF2_13120 ENOG4108K4B hydrolase OJF2_13220 ENOG4105CBG Sulfatase OJF2_13280 ENOG4105EPH radical SAM domain protein OJF2_13300 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) OJF2_13310 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) OJF2_13370 ENOG4105EMN RNA polymerase sigma factor OJF2_13390 ENOG4105CEY Amp-dependent synthetase and ligase OJF2_13490 ENOG4105D9P serine threonine protein kinase OJF2_13500 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) OJF2_13510 ENOG4107R7I amino acid OJF2_13530 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) OJF2_13540 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) OJF2_13550 ENOG41084BS 50S ribosomal protein L35 OJF2_13600 ENOG4105DI5 UPF0365 protein OJF2_13640 ENOG4108DN8 FAD dependent oxidoreductase OJF2_13660 ENOG4105DR4 Methyltransferase OJF2_13680 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) OJF2_13690 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) OJF2_13740 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_13810 ENOG4105C8S subunit m OJF2_13820 ENOG4105D65 subunit l OJF2_13850 ENOG4105CGZ zinc metallopeptidase OJF2_13860 ENOG4105C0H protease OJF2_13870 ENOG4106H78 methyltransferase OJF2_13880 ENOG4105DM4 PTS System OJF2_13940 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_14330 ENOG4105FDR Membrane OJF2_14340 ENOG4105FDR Membrane OJF2_14350 ENOG4105FDR Membrane OJF2_14360 ENOG4105F7P transcriptional regulator AsnC family OJF2_14390 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving OJF2_14560 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) OJF2_14590 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) OJF2_14630 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) OJF2_14760 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) OJF2_14770 ENOG4105CTQ phosphohexokinase OJF2_14790 ENOG4105D9P serine threonine protein kinase OJF2_14800 ENOG4105ECP epimerase OJF2_14810 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) OJF2_14920 ENOG4108PBA serine threonine protein kinase OJF2_15000 ENOG4105FA0 parb-like partition protein OJF2_15030 ENOG4105E66 phosphoriboisomerase A OJF2_15040 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) OJF2_15050 ENOG4105K4P CoA-binding domain protein OJF2_15090 ENOG4108RJ9 Glycosyl transferase, family 2 OJF2_15130 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) OJF2_15180 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_15190 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) OJF2_15200 ENOG4105C0H protease OJF2_15250 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) OJF2_15260 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase OJF2_15270 ENOG4105CHM Aminotransferase OJF2_15280 ENOG4105CDY transcriptional regulatory protein OJF2_15300 ENOG4105J3Z Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) OJF2_15320 ENOG41082KD Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) OJF2_15330 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) OJF2_15330 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) OJF2_15340 ENOG4105CHV Transcription elongation factor NusA OJF2_15350 ENOG4105F8V Hydrolase, tatD family OJF2_15370 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) OJF2_15390 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) OJF2_15400 ENOG4105DKQ ROK family OJF2_15500 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving OJF2_15520 ENOG4105D4A Cell wall formation (By similarity) OJF2_15550 ENOG4105D7N magnesium and cobalt transport protein CorA OJF2_15590 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) OJF2_15600 ENOG4108JPW Aminotransferase OJF2_15620 ENOG4105E39 Enoyl-CoA hydratase OJF2_15690 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) OJF2_15700 ENOG4105E8R UPF0173 metal-dependent hydrolase OJF2_15750 ENOG410600T transposase OJF2_15790 ENOG4108KQJ Type 11 methyltransferase OJF2_15800 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) OJF2_15810 ENOG4108DT4 serine threonine protein kinase OJF2_15840 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) OJF2_15850 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) OJF2_15890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit OJF2_15910 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase OJF2_15940 ENOG4105EYF MMPL domain protein OJF2_15960 ENOG4108QEV ribosomal RNA large subunit methyltransferase N OJF2_15970 ENOG4105C0H protease OJF2_15980 ENOG4105CHM Aminotransferase OJF2_16000 ENOG4105CTP PilT protein domain protein OJF2_16030 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) OJF2_16040 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) OJF2_16190 ENOG4105DR9 pseudouridine synthase OJF2_16200 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) OJF2_16210 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_16220 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_16260 ENOG4107RA9 decarboxylase OJF2_16280 ENOG4107QRG dna polymerase iii OJF2_16290 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) OJF2_16300 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) OJF2_16370 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) OJF2_16400 ENOG4106KS4 Sulfatase OJF2_16450 ENOG4105C34 Pseudouridine synthase OJF2_16470 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) OJF2_16480 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase OJF2_16490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OJF2_16510 ENOG4105BZU Histidine kinase OJF2_16530 ENOG4105CBS Chea signal transduction histidine kinase OJF2_16540 ENOG4105C8Q Methyl-accepting chemotaxis OJF2_16550 ENOG4108V3W Chemotaxis protein, CheW OJF2_16560 ENOG4105BZU Histidine kinase OJF2_16570 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) OJF2_16580 ENOG4105CQB FAD linked oxidase domain protein OJF2_16600 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) OJF2_16670 ENOG4105C59 p-type ATPase OJF2_16730 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) OJF2_16740 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) OJF2_16760 ENOG4105CKK Glycosyl transferase, family 2 OJF2_16780 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) OJF2_16800 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP OJF2_16810 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) OJF2_16830 ENOG4108UTW Plays a role in the regulation of phosphate uptake OJF2_16850 ENOG4105D9P serine threonine protein kinase OJF2_16860 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) OJF2_16890 ENOG4105C0B DNA polymerase III (alpha subunit) OJF2_17060 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) OJF2_17070 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) OJF2_17110 ENOG4105VN1 Heat shock protein OJF2_17160 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) OJF2_17170 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters OJF2_17190 ENOG4107RKG DJ-1/PfpI family OJF2_17200 ENOG4105C93 Xylose Isomerase OJF2_17240 ENOG4105CIB oxidoreductase Domain protein OJF2_17270 ENOG4105MRR Transcriptional regulator (By similarity) OJF2_17310 ENOG4105CS6 Rhs element vgr protein OJF2_17320 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) OJF2_17330 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit OJF2_17450 ENOG4105EMN RNA polymerase sigma factor OJF2_17480 ENOG4108ZF3 Phosphatase OJF2_17530 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) OJF2_17540 ENOG4108Z4U Ferredoxin OJF2_17560 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 OJF2_17590 ENOG4105S1Z Stage IV sporulation protein B OJF2_17610 ENOG4105WH1 Two component transcriptional regulator luxr family OJF2_17620 ENOG4105BZU Histidine kinase OJF2_17640 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase OJF2_17660 ENOG4105BZU Histidine kinase OJF2_17760 ENOG4105DSF transport protein OJF2_17770 ENOG4108VCA G U mismatch-specific DNA glycosylase OJF2_17790 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) OJF2_17810 ENOG4106H78 methyltransferase OJF2_17820 ENOG4105DJ0 Poly(A) Polymerase OJF2_17830 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) OJF2_17880 ENOG4105CFP Peptidase U32 OJF2_17930 ENOG410845M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes (By similarity) OJF2_17940 ENOG4105D6E homoserine dehydrogenase OJF2_17950 ENOG4105E3H phosphoglycerate mutase OJF2_17990 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) OJF2_18000 ENOG4108SDH ABC, transporter OJF2_18010 ENOG4108IUW ABC transporter OJF2_18020 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) OJF2_18040 ENOG4108R1E Serine threonine protein phosphatase 1 OJF2_18060 ENOG4105CA0 peroxidase OJF2_18090 ENOG4108Z0R Transferase OJF2_18110 ENOG4107SGM protein serine threonine phosphatase OJF2_18160 ENOG4105CK5 oxidoreductase OJF2_18170 ENOG4105CE4 GlcNAc 6-P deacetylase OJF2_18180 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) OJF2_18190 ENOG4108UW8 fha domain-containing protein OJF2_18220 ENOG4105CNA YD repeat protein OJF2_18250 ENOG4105CS6 Rhs element vgr protein OJF2_18270 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family OJF2_18310 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E OJF2_18400 ENOG4105DG6 mannose-6-phosphate isomerase OJF2_18410 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_18440 ENOG4105C3G gtp-binding protein OJF2_18480 ENOG4105CN1 protease OJF2_18570 ENOG4105CPC Aldo Keto reductase OJF2_18630 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) OJF2_18640 ENOG4108HMQ sugar kinase OJF2_18660 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) OJF2_18670 ENOG4106F60 Histidine kinase OJF2_18720 ENOG4105CRE cytochrome C OJF2_18760 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) OJF2_18790 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) OJF2_18800 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) OJF2_18810 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) OJF2_18820 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) OJF2_18830 ENOG41066YJ Beta-lactamase OJF2_18840 ENOG4105CHJ isochorismatase hydrolase OJF2_18850 ENOG4108ZM9 phosphoglycerate mutase OJF2_18890 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) OJF2_18930 ENOG4105CAQ asparagine synthetase OJF2_18980 ENOG4105CPC Aldo Keto reductase OJF2_18990 ENOG4105CN1 protease OJF2_19080 ENOG4105DJY efflux transporter, rnd family, mfp subunit OJF2_19080 ENOG4105DJY efflux transporter, rnd family, mfp subunit OJF2_19090 ENOG4105BZS acriflavin resistance protein OJF2_19110 ENOG4108YXG UPF0502 protein OJF2_19160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OJF2_19180 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_19190 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_19220 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain OJF2_19230 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) OJF2_19250 ENOG4108373 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_19260 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_19290 ENOG4105EEQ Na H antiporter OJF2_19320 ENOG4105BZU Histidine kinase OJF2_19340 ENOG4105EPC oxidoreductase OJF2_19390 ENOG4105CPP Dehydrogenase, E1 component OJF2_19400 ENOG4107RUY (E1 component), alpha subunit OJF2_19410 ENOG4105C7S Dehydrogenase OJF2_19440 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) OJF2_19560 ENOG4105BZS acriflavin resistance protein OJF2_19580 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction OJF2_19600 ENOG41085CY Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) OJF2_19610 ENOG4105CTJ Metal Dependent Phosphohydrolase OJF2_19620 ENOG4105C9A Phoh family OJF2_19630 ENOG4105KNE Phosphatidate cytidylyltransferase OJF2_19640 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) OJF2_19650 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis OJF2_19690 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain OJF2_19720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) OJF2_19740 ENOG4105C0H protease OJF2_19760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_19770 ENOG4105C0H protease OJF2_19820 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) OJF2_19890 ENOG4108JJB ABC transporter OJF2_19960 ENOG4108IJ9 (ABC) transporter OJF2_20000 ENOG4105C5X domain protein OJF2_20020 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) OJF2_20130 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) OJF2_20170 ENOG4105D9P serine threonine protein kinase OJF2_20220 ENOG4108KAZ Involved in phosphonate degradation (By similarity) OJF2_20230 ENOG41080HI glycine oxidase OJF2_20240 ENOG4108JA2 transcriptioN-repair coupling factor OJF2_20260 ENOG4105EMN RNA polymerase sigma factor OJF2_20270 ENOG4105DE4 1-phosphofructokinase OJF2_20300 ENOG4105CJ1 ABC, transporter OJF2_20320 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_20420 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) OJF2_20460 ENOG4105CNN ABC, transporter OJF2_20470 ENOG4105C2J ABC transporter OJF2_20480 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator OJF2_20500 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) OJF2_20620 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) OJF2_20650 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_20660 ENOG4105DTN riboflavin biosynthesis protein ribF OJF2_20730 ENOG4105CW7 secretion protein, HlyD family OJF2_20740 ENOG41067SE Tetr family transcriptional regulator OJF2_20760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase OJF2_20800 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_20830 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family OJF2_20840 ENOG4105CIG ABC transporter OJF2_20860 ENOG4105D9R oxidoreductase OJF2_20930 ENOG4108VPT UPF0234 protein OJF2_20960 ENOG4105C22 threonyL-tRNA synthetase OJF2_20970 ENOG4105EA8 2-Nitropropane dioxygenase OJF2_20980 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) OJF2_21020 ENOG4107QPV Serine Threonine protein kinase OJF2_21040 ENOG4107S52 alpha-2-macroglobulin domain protein OJF2_21050 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase OJF2_21060 ENOG4105D9P serine threonine protein kinase OJF2_21160 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 OJF2_21190 ENOG4107ZTW SNARE associated Golgi OJF2_21210 ENOG4105SFS phosphoesterase RecJ domain protein OJF2_21220 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) OJF2_21230 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) OJF2_21290 ENOG4105BZU Histidine kinase OJF2_21300 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) OJF2_21320 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) OJF2_21330 ENOG41084AE Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) OJF2_21340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OJF2_21370 ENOG4105CTQ phosphohexokinase OJF2_21380 ENOG4105DC1 bifunctional purine biosynthesis protein purh OJF2_21430 ENOG4108ZAF Molybdopterin OJF2_21440 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) OJF2_21470 ENOG4105DTQ mandelate racemase muconate lactonizing OJF2_21480 ENOG4105QTX Pfam:UPF0153 OJF2_21580 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) OJF2_21650 ENOG4105C5H ABC transporter OJF2_21690 ENOG4108IPT Naphthoate synthase OJF2_21700 ENOG4107RE7 phosphate butyryltransferase OJF2_21710 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase OJF2_21750 ENOG4108IJ8 ABC transporter OJF2_21760 ENOG4105E90 ABC transporter OJF2_21770 ENOG4105EAA nucleoside OJF2_21860 ENOG410811H Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) OJF2_21940 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) OJF2_21950 ENOG4105C1Q protoporphyrinogen oxidase OJF2_21980 ENOG4105BZU Histidine kinase OJF2_22050 ENOG41065RQ ADP-ribosylation crystallin J1 OJF2_22080 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) OJF2_22110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family OJF2_22140 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) OJF2_22170 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) OJF2_22250 ENOG4105D48 metallophosphoesterase OJF2_22260 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) OJF2_22350 ENOG4105EY8 ABC transporter OJF2_22410 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) OJF2_22420 ENOG41083AB Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) OJF2_22440 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) OJF2_22470 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain OJF2_22480 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_22490 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain OJF2_22500 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_22530 ENOG4108IEH NADH dehydrogenase subunit g OJF2_22540 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) OJF2_22550 ENOG41081XG NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_22560 ENOG4105DF2 NADH dehydrogenase subunit j OJF2_22570 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_22580 ENOG4105D65 subunit l OJF2_22590 ENOG4105C8S subunit m OJF2_22600 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) OJF2_22890 ENOG4105EMN RNA polymerase sigma factor OJF2_22910 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) OJF2_22920 ENOG4105CPC Aldo Keto reductase OJF2_22940 ENOG4105QUH Domain of unknown function (DUF2088) OJF2_23050 ENOG4105CKD glutathione-regulated potassium-efflux system protein OJF2_23060 ENOG4105CRK lysyL-tRNA synthetase OJF2_23070 ENOG4107VCI FtsX-like permease family OJF2_23080 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) OJF2_23090 ENOG4105CM2 brancheD-chain amino acid aminotransferase OJF2_23110 ENOG4108YZ4 nudix hydrolase OJF2_23170 ENOG4105DCG PHP domain protein OJF2_23270 ENOG4105DTQ mandelate racemase muconate lactonizing OJF2_23280 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) OJF2_23390 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit OJF2_23440 ENOG4105D9P serine threonine protein kinase OJF2_23640 ENOG4107QP8 phosphohexose isomerase OJF2_23690 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) OJF2_23700 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase OJF2_23710 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) OJF2_23730 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation OJF2_23770 ENOG4105EJG cellulose synthase OJF2_23790 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) OJF2_23810 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) OJF2_23880 ENOG4108IAJ Nad-dependent epimerase dehydratase OJF2_23930 ENOG4105CK5 oxidoreductase OJF2_24000 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) OJF2_24060 ENOG4105BZU Histidine kinase OJF2_24150 ENOG41076QQ Glycosyl transferase, family 2 OJF2_24180 ENOG4105C8M UPF0272 protein OJF2_24230 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_24280 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) OJF2_24290 ENOG4108RWN rrna methyltransferase OJF2_24310 ENOG4107SGM protein serine threonine phosphatase OJF2_24350 ENOG4105C0D helicase OJF2_24360 ENOG4105CK5 oxidoreductase OJF2_24370 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) OJF2_24390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase OJF2_24400 ENOG4107YV3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) OJF2_24420 ENOG4108UJU UPF0301 protein OJF2_24450 ENOG41066A3 ATP guanido phosphotransferase OJF2_24470 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) OJF2_24520 ENOG4105D49 3-dehydroquinate synthase OJF2_24580 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_24620 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) OJF2_24640 ENOG4105D06 uba thif-type nad fad binding protein OJF2_24660 ENOG4107R8N Glycosyl transferase, family 2 OJF2_24670 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase OJF2_24680 ENOG4105BZA Phosphoglycerate kinase OJF2_24700 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) OJF2_24720 ENOG4105I9Z UPF0264 protein OJF2_24770 ENOG4105D65 subunit l OJF2_24780 ENOG4105EVH UPF0753 protein OJF2_25060 ENOG4105CWX Alpha-1,2-mannosidase OJF2_25080 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) OJF2_25090 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) OJF2_25130 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) OJF2_25140 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) OJF2_25150 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) OJF2_25160 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) OJF2_25170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) OJF2_25230 ENOG4105DTQ mandelate racemase muconate lactonizing OJF2_25250 ENOG4105E0X reductase OJF2_25280 ENOG4105C9Q fumarate hydratase class II OJF2_25300 ENOG4107QRT dEAD DEAH box helicase OJF2_25310 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) OJF2_25340 ENOG4105D9P serine threonine protein kinase OJF2_25360 ENOG4105FJR Lmbe family OJF2_25380 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein OJF2_25470 ENOG4105D22 carbon starvation protein OJF2_25480 ENOG4105CUB amino acid OJF2_25520 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) OJF2_25550 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase OJF2_25560 ENOG4108NUU Transcriptional regulator OJF2_25640 ENOG4108QXE glycerophosphoryl diester phosphodiesterase OJF2_25650 ENOG4105BZU Histidine kinase OJF2_25740 ENOG4105EQI Metal Dependent Phosphohydrolase OJF2_25830 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) OJF2_25870 ENOG4105BZU Histidine kinase OJF2_25920 ENOG4105CZH peptidase OJF2_25940 ENOG4105SKN orotidine 5''-phosphate decarboxylase OJF2_25970 ENOG4108SJC Membrane OJF2_26000 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) OJF2_26070 ENOG41082XA Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) OJF2_26080 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) OJF2_26090 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) OJF2_26100 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) OJF2_26110 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) OJF2_26120 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) OJF2_26140 ENOG4107WJT it plays a direct role in the translocation of protons across the membrane (By similarity) OJF2_26200 ENOG4105VFU Rna-binding protein OJF2_26210 ENOG41083MR nifu domain-containing protein OJF2_26220 ENOG4105CSA Coproporphyrinogen iii oxidase OJF2_26250 ENOG4107R7I amino acid OJF2_26290 ENOG4105CP2 von willebrand factor, type a OJF2_26310 ENOG4105EEI dihydropteroate synthase OJF2_26340 ENOG41081EM Involved in DNA repair and RecF pathway recombination (By similarity) OJF2_26410 ENOG4105CJW magnesium transporter OJF2_26430 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) OJF2_26550 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_26600 ENOG4105D29 Helix-turn-helix type 11 domain protein OJF2_26630 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) OJF2_26650 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_26660 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) OJF2_26680 ENOG4105D9P serine threonine protein kinase OJF2_26730 ENOG4105D9P serine threonine protein kinase OJF2_26750 ENOG4105VE1 Phosphatidylcholine synthase OJF2_26770 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) OJF2_26800 ENOG4105D9P serine threonine protein kinase OJF2_26810 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) OJF2_26820 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) OJF2_26830 ENOG4105CUT histidyl-tRNA synthetase OJF2_26840 ENOG4105CUT histidyl-tRNA synthetase OJF2_26850 ENOG4105GFR rna polymerase sigma factor OJF2_26870 ENOG4105CPQ Dehydrogenase OJF2_26940 ENOG4105NWF RbsD or FucU transport OJF2_26960 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) OJF2_26970 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins OJF2_26990 ENOG41072GX Peptidase M22 Glycoprotease OJF2_27000 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) OJF2_27050 ENOG4107UWA esterase OJF2_27060 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) OJF2_27100 ENOG4105CDU Replicative dna helicase OJF2_27110 ENOG4105K9Q Binds to the 23S rRNA (By similarity) OJF2_27120 ENOG4108UUM single-stranded DNA-binding protein OJF2_27140 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) OJF2_27150 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) OJF2_27220 ENOG4105CZX twitching motility protein OJF2_27280 ENOG4108UW8 fha domain-containing protein OJF2_27310 ENOG4105C0H protease OJF2_27340 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase OJF2_27420 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) OJF2_27440 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) OJF2_27540 ENOG4105C6Y Udp-glucose 6-dehydrogenase OJF2_27550 ENOG4105CKK Glycosyl transferase, family 2 OJF2_27560 ENOG4107QPH glycogen) synthase OJF2_27630 ENOG4105ENT Efflux transporter rnd family, mfp subunit OJF2_27720 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) OJF2_27740 ENOG4105VN1 Heat shock protein OJF2_27770 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein OJF2_27780 ENOG4105E0C molybdate abc transporter OJF2_27790 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) OJF2_27800 ENOG4105D9P serine threonine protein kinase OJF2_27890 ENOG4105DSQ Nitric oxide reductase OJF2_27910 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) OJF2_27920 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) OJF2_27930 ENOG4105ETX regulatoR OJF2_28010 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_28020 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) OJF2_28030 ENOG4105K64 Glycosyl transferase, family 2 OJF2_28140 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_28180 ENOG4105BZU Histidine kinase OJF2_28230 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_28400 ENOG4107QMS site-determining protein OJF2_28560 ENOG4107QYG anthranilate phosphoribosyltransferase OJF2_28570 ENOG4105C0H protease OJF2_28620 ENOG4105VFU Rna-binding protein OJF2_28650 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) OJF2_28700 ENOG4107GFK fumarate OJF2_28730 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) OJF2_28740 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) OJF2_28750 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) OJF2_28770 ENOG4105C2M dna polymerase I OJF2_28860 ENOG4105C9K Endothelin-converting enzyme 1 OJF2_28920 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) OJF2_28960 ENOG4107RAN Peptidase, M16 OJF2_28990 ENOG4105CI2 imidazolone-5-propionate hydrolase OJF2_29090 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) OJF2_29120 ENOG4105C37 (CBS) domain OJF2_29130 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) OJF2_29140 ENOG4107QR9 Iron-sulfur cluster binding protein OJF2_29150 ENOG41080R8 Conserved Protein OJF2_29190 ENOG4108V5V Serine Threonine protein kinase OJF2_29220 ENOG4105CJ2 (LipO)protein OJF2_29260 ENOG4105EPC oxidoreductase OJF2_29380 ENOG4105E08 Glycoside hydrolase, family 9 OJF2_29400 ENOG4105DKQ ROK family OJF2_29430 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) OJF2_29440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase OJF2_29460 ENOG4107WAU Protein tyrosine phosphatase OJF2_29480 ENOG4105CY3 ABC transporter, permease OJF2_29490 ENOG4108IJ6 ABC transporter OJF2_29510 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_29570 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) OJF2_29590 ENOG4106PBJ Serine threonine-protein kinase Pkn6 OJF2_29600 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) OJF2_29680 ENOG41073TP transcriptional regulator OJF2_29720 ENOG4107VXM glycerophosphoryl diester phosphodiesterase OJF2_29770 ENOG4105K8R UPF0145 protein OJF2_29910 ENOG4108DT4 serine threonine protein kinase OJF2_29980 ENOG4108I5G Major Facilitator superfamily OJF2_30000 ENOG4105ETX regulatoR OJF2_30010 ENOG4105GR3 Histidine kinase OJF2_30050 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase OJF2_30070 ENOG4105CKK Glycosyl transferase, family 2 OJF2_30110 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) OJF2_30120 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) OJF2_30140 ENOG4107T0X DNA ligase OJF2_30170 ENOG4105D9P serine threonine protein kinase OJF2_30210 ENOG4105CV8 reductase OJF2_30220 ENOG4105C0X amino acid OJF2_30240 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) OJF2_30270 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) OJF2_30280 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) OJF2_30290 ENOG4105EX0 alpha-galactosidase OJF2_30320 ENOG4105CQB FAD linked oxidase domain protein OJF2_30430 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) OJF2_30490 ENOG4105NUP lyase containing HEAT-repeat OJF2_30500 ENOG4105E6M Sulphatase-modifying factor protein OJF2_30540 ENOG4107S1Q Phosphatase OJF2_30590 ENOG4105CBG Sulfatase OJF2_30610 ENOG410756H nucleotidyltransferase OJF2_30640 ENOG4105BZU Histidine kinase OJF2_30650 ENOG4105BZU Histidine kinase OJF2_30670 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase OJF2_30680 ENOG4105FUA antagonist OJF2_30690 ENOG4107MMM Anti-sigma-factor antagonist OJF2_30700 ENOG4105BZU Histidine kinase OJF2_30710 ENOG4105BZU Histidine kinase OJF2_30790 ENOG4105WMR Protein CrcB homolog OJF2_30800 ENOG4105KJJ Uncharacterized ACR, COG1993 OJF2_30810 ENOG4108N5B 2-phosphosulfolactate phosphatase OJF2_30820 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) OJF2_30930 ENOG4108RPX mosc domain containing protein OJF2_30960 ENOG4105D9P serine threonine protein kinase OJF2_30990 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) OJF2_31060 ENOG4105DU6 RNA polymerase OJF2_31070 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) OJF2_31080 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) OJF2_31170 ENOG4105CHM Aminotransferase OJF2_31300 ENOG4107R6D beta-lactam binding protein AmpH OJF2_31310 ENOG4107QVM von Willebrand factor, type A OJF2_31350 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_31370 ENOG4107TVC Glycosyl transferase, family 2 OJF2_31430 ENOG4105CBG Sulfatase OJF2_31540 ENOG4107QRT dEAD DEAH box helicase OJF2_31610 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_31790 ENOG4108VAU general secretion pathway protein G OJF2_31800 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) OJF2_31820 ENOG4105CMQ Chloride channel OJF2_31870 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) OJF2_31880 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) OJF2_31890 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) OJF2_31930 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) OJF2_31940 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) OJF2_31950 ENOG4105D9P serine threonine protein kinase OJF2_32010 ENOG4105CPC Aldo Keto reductase OJF2_32040 ENOG4105D9P serine threonine protein kinase OJF2_32100 ENOG4105CAQ asparagine synthetase OJF2_32210 ENOG4105CY0 Metallo-Beta-Lactamase OJF2_32220 ENOG41061TZ Short-chain dehydrogenase reductase Sdr OJF2_32340 ENOG4105CY3 ABC transporter, permease OJF2_32390 ENOG4105BZU Histidine kinase OJF2_32400 ENOG4105EMN RNA polymerase sigma factor OJF2_32430 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) OJF2_32440 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_32450 ENOG4105CYC Transferase OJF2_32460 ENOG4105C7K acetolactate synthase OJF2_32490 ENOG4105EU0 Major facilitator Superfamily OJF2_32520 ENOG4105VQD rieske 2fe-2S domain-containing protein OJF2_32530 ENOG4107VFM Dehydrogenase OJF2_32580 ENOG4105BZU Histidine kinase OJF2_32590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_32630 ENOG4105NXH GreA GreB family elongation factor OJF2_32670 ENOG4108594 Permease of the drug metabolite transporter OJF2_32700 ENOG4105ENH Sulfatase OJF2_32790 ENOG4105IBP Cyclic peptide transporter OJF2_32810 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_32820 ENOG4105WD1 Membrane OJF2_32830 ENOG4107R7I amino acid OJF2_32890 ENOG4105XJC Two component transcriptional regulator (Winged helix family OJF2_32900 ENOG4106F60 Histidine kinase OJF2_32910 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) OJF2_32990 ENOG4107QHQ amino acid OJF2_33010 ENOG4105DDI hemolysin-type calcium-binding region OJF2_33030 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_33060 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) OJF2_33070 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) OJF2_33100 ENOG4105NBF ammecr1 domain protein OJF2_33110 ENOG4105BZU Histidine kinase OJF2_33150 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) OJF2_33160 ENOG4105CHR reductase OJF2_33170 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase OJF2_33180 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) OJF2_33210 ENOG4107RGC Glycosyl transferase, family 2 OJF2_33250 ENOG4105CYX Short-chain dehydrogenase reductase Sdr OJF2_33290 ENOG4105WEF catalase OJF2_33310 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) OJF2_33350 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) OJF2_33390 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) OJF2_33400 ENOG4105FE9 pseudouridine synthase OJF2_33430 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) OJF2_33440 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) OJF2_33460 ENOG4105CQS hydrogenase expression formation protein HypD OJF2_33540 ENOG4108SU4 UPF0309 protein OJF2_33550 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr OJF2_33570 ENOG4105BZU Histidine kinase OJF2_33580 ENOG4107Z5C methylesterase OJF2_33590 ENOG4105BZU Histidine kinase OJF2_33600 ENOG4105BZU Histidine kinase OJF2_33640 ENOG4105D9P serine threonine protein kinase OJF2_33690 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_33740 ENOG41061MV Arylsulfatase OJF2_33750 ENOG4105D64 Mechanosensitive ion channel OJF2_33820 ENOG4107SJ9 decarboxylase OJF2_33830 ENOG4107QWG 2-Nitropropane dioxygenase OJF2_33840 ENOG4105C9B Cysteine desulfurase OJF2_33860 ENOG4105CSM endonuclease III OJF2_33920 ENOG4105D9P serine threonine protein kinase OJF2_33950 ENOG4106I9T OJF2_34010 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_34020 ENOG4107TPY serine threonine protein kinase OJF2_34100 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) OJF2_34110 ENOG4106N3A copper homeostasis protein cutc OJF2_34130 ENOG4105D9P serine threonine protein kinase OJF2_34230 ENOG4107RA9 decarboxylase OJF2_34270 ENOG4108V1U phospholipid-binding protein OJF2_34330 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) OJF2_34380 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) OJF2_34390 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) OJF2_34740 ENOG4105C0A alcohol dehydrogenase OJF2_34760 ENOG4105BZU Histidine kinase OJF2_34770 ENOG4107SGM protein serine threonine phosphatase OJF2_34790 ENOG4108IXY short-chain dehydrogenase reductase OJF2_34870 ENOG4105CJ1 ABC, transporter OJF2_34890 ENOG4105CIG ABC transporter OJF2_34910 ENOG4108R99 pseudouridine synthase OJF2_34950 ENOG4105BZ1 (ABC) transporter OJF2_34980 ENOG4105XEA Tetr family transcriptional regulator OJF2_35050 ENOG4105BZU Histidine kinase OJF2_35070 ENOG4105BZU Histidine kinase OJF2_35130 ENOG4105D9P serine threonine protein kinase OJF2_35170 ENOG4105C7B Threonine dehydratase OJF2_35190 ENOG4107VGF ig domain protein group 2 domain protein OJF2_35220 ENOG4108PBA serine threonine protein kinase OJF2_35230 ENOG4108Z9K Osmotically inducible protein OJF2_35390 ENOG410901P UPF0249 protein OJF2_35430 ENOG4107YB1 Trehalose corynomycolyl transferase OJF2_35460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) OJF2_35540 ENOG4105D9P serine threonine protein kinase OJF2_35630 ENOG4105K64 Glycosyl transferase, family 2 OJF2_35670 ENOG4105CN1 protease OJF2_35720 ENOG4108KQ5 Integrase catalytic subunit OJF2_35970 ENOG4105DFS Conserved Protein OJF2_36070 ENOG4105EAH synthase OJF2_36090 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_36100 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) OJF2_36120 ENOG4105C6E dna polymerase iii OJF2_36130 ENOG4105JZI cytochrome P450 OJF2_36180 ENOG4105CSM endonuclease III OJF2_36250 ENOG4105KPY Small multidrug resistance protein OJF2_36360 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) OJF2_36380 ENOG4105KK4 UPF0060 membrane protein OJF2_36400 ENOG4105D9P serine threonine protein kinase OJF2_36410 ENOG4108MMM RNA Polymerase OJF2_36480 ENOG4105JQN Transcriptional regulator OJF2_36540 ENOG4108UK5 Transposase OJF2_36560 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system OJF2_36710 ENOG4105C26 Dehydrogenase OJF2_36720 ENOG4105WDY DNA (cytosine-5-)-methyltransferase OJF2_36740 ENOG4107RGD Major Facilitator superfamily OJF2_36790 ENOG4108V0P LemA family OJF2_36830 ENOG4105CTU Proline racemase OJF2_36840 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) OJF2_36920 ENOG4105DJB Major Facilitator Superfamily OJF2_36940 ENOG4105CK5 oxidoreductase OJF2_37010 ENOG4105CHU acetyl-coa acetyltransferase OJF2_37030 ENOG4105CHR reductase OJF2_37050 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class OJF2_37060 ENOG4107QPV Serine Threonine protein kinase OJF2_37070 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_37080 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase OJF2_37090 ENOG4107QX3 carboxylase OJF2_37110 ENOG4105DJT lAO AO transport system ATPase OJF2_37160 ENOG4105T16 Transcriptional regulator (AraC family) OJF2_37180 ENOG4108NQD OJF2_37200 ENOG4105CHR reductase OJF2_37220 ENOG4106J7G oxidoreductase OJF2_37240 ENOG4105CNN ABC, transporter OJF2_37250 ENOG4105C2J ABC transporter OJF2_37260 ENOG4105CNN ABC, transporter OJF2_37370 ENOG4105D9P serine threonine protein kinase OJF2_37400 ENOG4107RE3 peptidase, S41 OJF2_37420 ENOG4105BZU Histidine kinase OJF2_37610 ENOG4105D9P serine threonine protein kinase OJF2_37620 ENOG4105D9P serine threonine protein kinase OJF2_37800 ENOG4105CGD Nad-dependent epimerase dehydratase OJF2_37830 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein OJF2_37850 ENOG4105D9P serine threonine protein kinase OJF2_37920 ENOG4105D5T phosphonate abc transporter OJF2_38030 ENOG4106D4I domain protein OJF2_38040 ENOG4105DZW Dipeptidase OJF2_38050 ENOG4107VRP DNA repair exonuclease OJF2_38060 ENOG4105D9P serine threonine protein kinase OJF2_38130 ENOG4105BZU Histidine kinase OJF2_38150 ENOG4105BZU Histidine kinase OJF2_38220 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) OJF2_38240 ENOG4105DCI Phosphohydrolase OJF2_38260 ENOG4107QI1 Mate efflux family protein OJF2_38280 ENOG4107QPV Serine Threonine protein kinase OJF2_38290 ENOG4105DK0 Indole-3-glycerol phosphate synthase OJF2_38390 ENOG4107TPS domain protein OJF2_38400 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) OJF2_38410 ENOG4108SHN Glycosyl transferase, family 2 OJF2_38470 ENOG4105CKK Glycosyl transferase, family 2 OJF2_38580 ENOG4105C0D helicase OJF2_38590 ENOG4105JD4 ATPase yjob OJF2_38600 ENOG4107STF Involved in phosphonate degradation (By similarity) OJF2_38640 ENOG4105CV8 reductase OJF2_38690 ENOG4105CJW magnesium transporter OJF2_38700 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) OJF2_38710 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) OJF2_38740 ENOG4107EPN Domain of unknown function (DUF1508) OJF2_38800 ENOG4105DQE DNA ligase OJF2_38850 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) OJF2_38860 ENOG4105GYT Protein of unknown function (DUF1009) OJF2_38930 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) OJF2_39000 ENOG4108UT2 hemolysin iii OJF2_39050 ENOG4105EJQ L-serine dehydratase OJF2_39180 ENOG4105ERH Fumarylacetoacetate hydrolase OJF2_39320 ENOG4105CN1 protease OJF2_39460 ENOG4108KQ5 Integrase catalytic subunit OJF2_39510 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein OJF2_39560 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) OJF2_39570 ENOG4105CHM Aminotransferase OJF2_39580 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) OJF2_39650 ENOG4105D9P serine threonine protein kinase OJF2_39670 ENOG4105EMN RNA polymerase sigma factor OJF2_39720 ENOG4108V5V Serine Threonine protein kinase OJF2_39840 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) OJF2_39850 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) OJF2_39890 ENOG4107QQG Dehydrogenase OJF2_39990 ENOG4105YAJ CopG Arc MetJ OJF2_40050 ENOG4105BZU Histidine kinase OJF2_40060 ENOG4107Z5C methylesterase OJF2_40070 ENOG4105BZU Histidine kinase OJF2_40080 ENOG4105BZU Histidine kinase OJF2_40100 ENOG4105D9P serine threonine protein kinase OJF2_40180 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein OJF2_40220 ENOG4105WH9 RNA polymerase OJF2_40230 ENOG4105D9P serine threonine protein kinase OJF2_40340 ENOG4105E5H Transposase OJF2_40380 ENOG4105CI2 imidazolone-5-propionate hydrolase OJF2_40410 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein OJF2_40510 ENOG4105D9P serine threonine protein kinase OJF2_40580 ENOG4105DFS Conserved Protein OJF2_40610 ENOG4105M8K biopolymer transport protein OJF2_40620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OJF2_40680 ENOG4105CVK Glutamate decarboxylase OJF2_40730 ENOG4105BZU Histidine kinase OJF2_40790 ENOG4107QX3 carboxylase OJF2_40840 ENOG4105CEY Amp-dependent synthetase and ligase OJF2_40960 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) OJF2_41030 ENOG4105EMN RNA polymerase sigma factor OJF2_41050 ENOG4105DQ4 alcohol dehydrogenase OJF2_41060 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein OJF2_41130 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) OJF2_41150 ENOG4105D0M Protease HtpX homolog OJF2_41240 ENOG4105C7Z Conserved Protein OJF2_41270 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) OJF2_41280 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) OJF2_41300 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) OJF2_41340 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin OJF2_41690 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase OJF2_41820 ENOG4105EYH Exonuclease OJF2_41940 ENOG4108IJF Heavy metal efflux pump, CzcA OJF2_42020 ENOG4105D9P serine threonine protein kinase OJF2_42050 ENOG4107ZT5 Thiol disulfide interchange protein OJF2_42100 ENOG4107RBS Methyltransferase OJF2_42160 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) OJF2_42230 ENOG4105CSR polyphosphate kinase 2 OJF2_42240 ENOG4105YAJ CopG Arc MetJ OJF2_42250 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) OJF2_42270 ENOG4105CHR reductase OJF2_42310 ENOG4105D9P serine threonine protein kinase OJF2_42330 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for OJF2_42380 ENOG4105E02 MotA TolQ exbB proton channel OJF2_42390 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) OJF2_42400 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) OJF2_42440 ENOG4105BZU Histidine kinase OJF2_42450 ENOG4108MGY Histidine kinase OJF2_42590 ENOG4105ECP epimerase OJF2_42720 ENOG4105MHT Transcriptional regulator, ARSR family OJF2_42740 ENOG4107TK4 histidinol-phosphate phosphatase OJF2_42810 ENOG4105UKP Protein of unknown function (DUF1778) OJF2_42880 ENOG4105T16 Transcriptional regulator (AraC family) OJF2_42890 ENOG4105F0Z galactose-1-phosphate uridylyltransferase OJF2_42900 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) OJF2_42920 ENOG4105CMR udp-glucose 4-epimerase OJF2_43010 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) OJF2_43030 ENOG4105CN7 Flagellar biosynthetic protein FliP OJF2_43040 ENOG4105VS8 Flagellar biosynthetic protein fliq OJF2_43070 ENOG4105C26 Dehydrogenase OJF2_43080 ENOG4105CPC Aldo Keto reductase OJF2_43090 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) OJF2_43110 ENOG4105D9P serine threonine protein kinase OJF2_43150 ENOG4105D7B Flagellar biosynthesis protein flha OJF2_43160 ENOG4105FZW flagellar biosynthesis regulator FlhF OJF2_43190 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_43230 ENOG4105C0D helicase OJF2_43250 ENOG4105BZU Histidine kinase OJF2_43280 ENOG4108VAU general secretion pathway protein G OJF2_43330 ENOG4105EUJ GTP cyclohydrolase i OJF2_43360 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) OJF2_43470 ENOG4105C5H ABC transporter OJF2_43490 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) OJF2_43530 ENOG4105E0X reductase OJF2_43550 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_43630 ENOG4105CBG Sulfatase OJF2_43710 ENOG4108Z1Z gCN5-related N-acetyltransferase OJF2_43780 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein OJF2_43790 ENOG4107VGR Catalase OJF2_43820 ENOG4107S5I aldo keto reductase OJF2_43830 ENOG4105CIH Imidazole acetol-phosphate transaminase OJF2_43880 ENOG4105CBG Sulfatase OJF2_43900 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) OJF2_43960 ENOG4105HEE Binding Domain protein OJF2_43970 ENOG4105CK5 oxidoreductase OJF2_44000 ENOG4105D9P serine threonine protein kinase OJF2_44040 ENOG4107T8Q Glycosyl transferase (Group 1 OJF2_44050 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) OJF2_44070 ENOG4105GVR general secretion pathway protein D OJF2_44130 ENOG4105D7Q type ii secretion system OJF2_44140 ENOG4106855 Competence protein OJF2_44180 ENOG4107QHF type ii secretion system protein e OJF2_44190 ENOG4105CYX Short-chain dehydrogenase reductase Sdr OJF2_44220 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) OJF2_44260 ENOG4107FQX Alpha-acetolactate decarboxylase OJF2_44290 ENOG4108KPJ rna polymerase sigma factor OJF2_44310 ENOG4108Z66 YbaK ebsC protein OJF2_44320 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_44400 ENOG4107R1I NAD-dependent malic enzyme OJF2_44410 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) OJF2_44440 ENOG4108KQ5 Integrase catalytic subunit OJF2_44450 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) OJF2_44560 ENOG4105CDY transcriptional regulatory protein OJF2_44600 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) OJF2_44610 ENOG4105EMN RNA polymerase sigma factor OJF2_44620 ENOG4105EPC oxidoreductase OJF2_44640 ENOG4105ECY inositol monophosphatase OJF2_44680 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) OJF2_44720 ENOG4107TRN Xylose isomerase domain protein TIM barrel OJF2_44740 ENOG4108Z9Z response to DNA damage stimulus OJF2_44780 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_44800 ENOG4105CPQ Dehydrogenase OJF2_44810 ENOG4105BZP glycoside hydrolase 15-related OJF2_44820 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) OJF2_44890 ENOG4105VFU Rna-binding protein OJF2_44910 ENOG4107U9T Pfam:Ribonuclease_BN OJF2_44930 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) OJF2_44940 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) OJF2_44950 ENOG4105DU6 RNA polymerase OJF2_44960 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs OJF2_45000 ENOG4105EMN RNA polymerase sigma factor OJF2_45160 ENOG4105BZU Histidine kinase OJF2_45170 ENOG4105D74 hydrolase OJF2_45190 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) OJF2_45300 ENOG4105EMN RNA polymerase sigma factor OJF2_45420 ENOG4105CNG UPF0061 protein OJF2_45470 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) OJF2_45520 ENOG4105DA5 (ABC) transporter OJF2_45560 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) OJF2_45690 ENOG4108JJA ABC, transporter OJF2_45730 ENOG4105D9P serine threonine protein kinase OJF2_45750 ENOG4105C3K feS assembly ATPase SufC OJF2_45760 ENOG4105DIW FeS assembly protein SUFB OJF2_45770 ENOG4105JRK feS assembly protein SufD OJF2_45780 ENOG4105KHC sulfurtransferase OJF2_45860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_45870 ENOG4108V1T peptidylprolyl cis-trans isomerase OJF2_45930 ENOG4108ZCF integral membrane protein OJF2_45940 ENOG4105CJ2 (LipO)protein OJF2_45980 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) OJF2_45990 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) OJF2_46010 ENOG4107TE5 Lipid kinase OJF2_46060 ENOG4105C7Z Conserved Protein OJF2_46100 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) OJF2_46160 ENOG410631K Membrane OJF2_46170 ENOG4105F6U Short-chain dehydrogenase reductase Sdr OJF2_46210 ENOG4105DEG Vwa containing coxe family protein OJF2_46230 ENOG4105KKX ATPase associated with various cellular activities aaa_5 OJF2_46260 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein OJF2_46310 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase OJF2_46360 ENOG4105D52 delta-aminolevulinic acid dehydratase OJF2_46370 ENOG4105C03 ribonuclease OJF2_46390 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) OJF2_46400 ENOG41080Z8 PHOSPHOCARRIER protein OJF2_46410 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN OJF2_46430 ENOG4105DAA L-lactate OJF2_46580 ENOG4105EGS Mechanosensitive ion channel OJF2_46600 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) OJF2_46610 ENOG4105M0T TPR Repeat-Containing Protein OJF2_46620 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase OJF2_46630 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase OJF2_46650 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) OJF2_46680 ENOG4105C0H protease OJF2_46700 ENOG4105C26 Dehydrogenase OJF2_46720 ENOG4105M3Z response regulator OJF2_46730 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control OJF2_46790 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) OJF2_46830 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_46980 ENOG4105JXH GntR family transcriptional regulator OJF2_47010 ENOG4108PBA serine threonine protein kinase OJF2_47040 ENOG4105C25 Primosomal protein n' OJF2_47050 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) OJF2_47060 ENOG4105CHR reductase OJF2_47070 ENOG4105C31 Tryptophanyl-tRNA synthetase OJF2_47110 ENOG4105D9P serine threonine protein kinase OJF2_47120 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) OJF2_47190 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) OJF2_47240 ENOG4105DCF alanine dehydrogenase OJF2_47260 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) OJF2_47310 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_47330 ENOG4107FW0 short-chain dehydrogenase reductase OJF2_47340 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) OJF2_47360 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) OJF2_47400 ENOG4107R39 (ABC) transporter OJF2_47410 ENOG4107R34 abc transporter permease protein OJF2_47460 ENOG4105E5J UV damage endonuclease OJF2_47480 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) OJF2_47550 ENOG4105DRR Transcriptional regulator, GntR family OJF2_47560 ENOG4105DKW ABC transporter OJF2_47620 ENOG4105ETX regulatoR OJF2_47630 ENOG4105GR3 Histidine kinase OJF2_47660 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase OJF2_47670 ENOG4105CH7 arginosuccinase OJF2_47680 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) OJF2_47700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_47770 ENOG4107TPY serine threonine protein kinase OJF2_47800 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) OJF2_47830 ENOG4105CFH Aspartokinase OJF2_47850 ENOG4105CDH Citrulline--aspartate ligase OJF2_47870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) OJF2_47880 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) OJF2_47890 ENOG4105VIE preprotein translocase, subunit YajC OJF2_47900 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) OJF2_47970 ENOG4105ENT Efflux transporter rnd family, mfp subunit OJF2_48020 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) OJF2_48030 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) OJF2_48050 ENOG4105CHR reductase OJF2_48120 ENOG4105E6M Sulphatase-modifying factor protein OJF2_48130 ENOG4105EHZ conserved protein UCP016719 OJF2_48200 ENOG4105D9P serine threonine protein kinase OJF2_48230 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) OJF2_48240 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) OJF2_48250 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) OJF2_48300 ENOG4105EFX secretion protein, HlyD family OJF2_48310 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) OJF2_48390 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) OJF2_48490 ENOG4105DU6 RNA polymerase OJF2_48510 ENOG4107QN2 dihydrolipoyl dehydrogenase OJF2_48520 ENOG4105C7S Dehydrogenase OJF2_48530 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 OJF2_48560 ENOG4105CXB phosphoribosylaminoimidazole synthetase OJF2_48580 ENOG4108IYU L-aspartate oxidase OJF2_48600 ENOG4107TVP HD domain protein OJF2_48610 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) OJF2_48670 ENOG4105CEV competence damage-inducible protein OJF2_48710 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) OJF2_48730 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB OJF2_48830 ENOG4105CIG ABC transporter OJF2_48920 ENOG4105ETX regulatoR OJF2_48930 ENOG4105BZU Histidine kinase OJF2_48950 ENOG4108JQ1 Dehydrogenase OJF2_49020 ENOG41082AN stage II sporulation protein OJF2_49040 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) OJF2_49080 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) OJF2_49140 ENOG4105CBG Sulfatase OJF2_49150 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) OJF2_49200 ENOG4108UPT UPF0178 protein OJF2_49230 ENOG4105CJ1 ABC, transporter OJF2_49320 ENOG4105DVW rieske (2Fe-2S) OJF2_49340 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase OJF2_49380 ENOG4105CJ1 ABC, transporter OJF2_49420 ENOG4105BZU Histidine kinase OJF2_49430 ENOG4105BZU Histidine kinase OJF2_49480 ENOG4107UVV polysaccharide deacetylase OJF2_49510 ENOG4105EY8 ABC transporter OJF2_49530 ENOG4105K64 Glycosyl transferase, family 2 OJF2_49590 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_49650 ENOG4108Z6B deaminase OJF2_49670 ENOG4105D3Q Sugar transferase OJF2_49680 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) OJF2_49690 ENOG4107TTA Xylose isomerase domain protein TIM barrel OJF2_49730 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) OJF2_49740 ENOG4108JQ1 Dehydrogenase OJF2_49770 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) OJF2_49800 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) OJF2_49870 ENOG4105DBV ornithine carbamoyltransferase OJF2_49880 ENOG4105C8Y Acetylornithine aminotransferase OJF2_49890 ENOG4105CAS nag kinase OJF2_49930 ENOG4107QM5 aconitate hydratase OJF2_49940 ENOG4105E63 Pfam:DUF178 OJF2_49950 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) OJF2_49980 ENOG4105D9P serine threonine protein kinase OJF2_49990 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) OJF2_50000 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) OJF2_50010 ENOG41082DI 50s ribosomal protein l31 OJF2_50180 ENOG4105KZX Pterin carbinolamine dehydratase OJF2_50220 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) OJF2_50240 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase OJF2_50290 ENOG4105CNU cell division protein FtsK OJF2_50610 ENOG4105E0Y RtcB Protein OJF2_51030 ENOG4108N0N Phage Terminase Large Subunit OJF2_51070 ENOG4107QYX exodeoxyribonuclease v alpha OJF2_51130 ENOG4105CFI type iii restriction protein res subunit OJF2_51700 ENOG4105FA0 parb-like partition protein OJF2_51880 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) OJF2_51980 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) OJF2_51990 ENOG4105FB2 class II Aldolase OJF2_52030 ENOG4108EKI Dehydrogenase OJF2_52050 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) OJF2_52060 ENOG4105KNY Microcompartments protein OJF2_52070 ENOG4105KNY Microcompartments protein OJF2_52080 ENOG4105KNY Microcompartments protein OJF2_52090 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) OJF2_52190 ENOG4105CW7 secretion protein, HlyD family OJF2_52200 ENOG4105C0R drug resistance transporter emrb qaca subfamily OJF2_52210 ENOG4105BZU Histidine kinase OJF2_52220 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) OJF2_52230 ENOG41090R7 Ferric uptake OJF2_52240 ENOG4108R1E Serine threonine protein phosphatase 1 OJF2_52250 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) OJF2_52260 ENOG4108KQJ Type 11 methyltransferase OJF2_52300 ENOG4108JYK Dehydrogenase OJF2_52310 ENOG4105CPP Dehydrogenase, E1 component OJF2_52330 ENOG4107QN2 dihydrolipoyl dehydrogenase OJF2_52370 ENOG4107QQG Dehydrogenase OJF2_52390 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) OJF2_52410 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ OJF2_52420 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) OJF2_52430 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) OJF2_52440 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) OJF2_52450 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) OJF2_52480 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_52490 ENOG4105C9M aspartyl-trna synthetase OJF2_52530 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) OJF2_52540 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) OJF2_52550 ENOG4108HMX isocitrate dehydrogenase (NADP) OJF2_52560 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) OJF2_52590 ENOG4105C3J Cysteine desulfurase OJF2_52600 ENOG4108YX9 iron--sulfur cluster insertion protein erpA OJF2_52640 ENOG4105T2N Domain of unknown function (DUF2382) OJF2_52670 ENOG4105K5M 30s ribosomal protein S16 OJF2_52680 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) OJF2_52690 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) OJF2_52720 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) OJF2_52730 ENOG4105CQB FAD linked oxidase domain protein OJF2_52750 ENOG4105EU8 FAD linked oxidase domain protein OJF2_52760 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) OJF2_52780 ENOG4107QP3 malate synthase g OJF2_52790 ENOG4107R11 Transcriptional regulator OJF2_52800 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase OJF2_52880 ENOG4108TWJ NADH dehydrogenase subunit 5 OJF2_52890 ENOG4105EVH UPF0753 protein OJF2_52930 ENOG4105D9R oxidoreductase OJF2_52980 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein OJF2_53020 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) OJF2_53030 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) OJF2_53040 ENOG4105D9N nucleoside OJF2_53220 ENOG4105BZU Histidine kinase OJF2_53230 ENOG4105C1P efflux transporter, rnd family, mfp subunit OJF2_53280 ENOG4105EKQ RNA-directed DNA polymerase OJF2_53290 ENOG4105EKQ RNA-directed DNA polymerase OJF2_53320 ENOG4105CMM transposase OJF2_53470 ENOG4107QHF type ii secretion system protein e OJF2_53550 ENOG4105EMN RNA polymerase sigma factor OJF2_53570 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_53620 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_53720 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) OJF2_53760 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) OJF2_53770 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) OJF2_53780 ENOG4105BZU Histidine kinase OJF2_53820 ENOG4105GRZ Ycii-related protein OJF2_53830 ENOG4105CHP RNA polymerase OJF2_53850 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) OJF2_53860 ENOG4105E2X shikimate dehydrogenase OJF2_53870 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) OJF2_53900 ENOG4108RPX mosc domain containing protein OJF2_53930 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) OJF2_53940 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase OJF2_53950 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) OJF2_53970 ENOG4105C3R Methionine synthase OJF2_54030 ENOG4105D1H recombination factor protein RarA OJF2_54090 ENOG4105C5H ABC transporter OJF2_54100 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) OJF2_54240 ENOG4105DUX Transporter OJF2_54250 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein OJF2_54260 ENOG4108IUW ABC transporter OJF2_54300 ENOG4105CKU formyltetrahydrofolate synthetase OJF2_54360 ENOG4108Z7G MaoC domain protein dehydratase OJF2_54370 ENOG4108NEV two component transcriptional regulator, LytTR family OJF2_54480 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_54540 ENOG4108R6B Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) OJF2_54550 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) OJF2_54560 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) OJF2_54570 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) OJF2_54580 ENOG4105C5H ABC transporter OJF2_54610 ENOG4105I82 acetyl xylan esterase OJF2_54640 ENOG41082BM Transcriptional regulator, arsr family OJF2_54650 ENOG4108URH decarboxylase OJF2_54660 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein OJF2_54680 ENOG4108YZN class I peptide chain release factor OJF2_54690 ENOG4105PWN phosphate abc transporter OJF2_54700 ENOG4105C8U phosphate abc transporter OJF2_54710 ENOG4105E2Z phosphate ABC transporter (Permease OJF2_54720 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) OJF2_54740 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_54760 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) OJF2_54810 ENOG4108V1T peptidylprolyl cis-trans isomerase OJF2_54890 ENOG4105D9P serine threonine protein kinase OJF2_54900 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) OJF2_54960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_55000 ENOG4105SG9 biopolymer transport protein, ExbD OJF2_55010 ENOG4105DQR SNARE associated Golgi OJF2_55070 ENOG4107R1I NAD-dependent malic enzyme OJF2_55100 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase OJF2_55110 ENOG4105EMN RNA polymerase sigma factor OJF2_55210 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) OJF2_55220 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) OJF2_55230 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) OJF2_55240 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) OJF2_55260 ENOG4107RGC Glycosyl transferase, family 2 OJF2_55280 ENOG4105DVT helicase OJF2_55290 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) OJF2_55300 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) OJF2_55310 ENOG4105C8N cysteinyl-tRNA synthetase OJF2_55320 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) OJF2_55330 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) OJF2_55340 ENOG4105CPC Aldo Keto reductase OJF2_55350 ENOG4105CPC Aldo Keto reductase OJF2_55390 ENOG4105C0P Mg chelatase subunit ChlI OJF2_55460 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) OJF2_55500 ENOG4105BZU Histidine kinase OJF2_55510 ENOG4105DR4 Methyltransferase OJF2_55550 ENOG4108Z03 MAF-like protein OJF2_55560 ENOG4108MXK alkaline phosphatase isozyme conversion OJF2_55650 ENOG4105CIG ABC transporter OJF2_55670 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit OJF2_55680 ENOG4107QIZ NADH dehydrogenase OJF2_55730 ENOG4107TIF Phenazine biosynthesis protein, PhzF family OJF2_55760 ENOG4107RAN Peptidase, M16 OJF2_55800 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) OJF2_55820 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase OJF2_55840 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) OJF2_55850 ENOG4105BZW Glycerate kinase OJF2_55860 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) OJF2_55870 ENOG4108097 ATP-binding protein OJF2_55890 ENOG4105CBX hi0933 family OJF2_55920 ENOG4107RRE RNA-directed DNA polymerase OJF2_55950 ENOG4105CEY Amp-dependent synthetase and ligase OJF2_55960 ENOG4105D9P serine threonine protein kinase OJF2_55980 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii OJF2_56000 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I OJF2_56030 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) OJF2_56050 ENOG4105DDI hemolysin-type calcium-binding region OJF2_56240 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator OJF2_56260 ENOG4105C0R drug resistance transporter emrb qaca subfamily OJF2_56300 ENOG4105BZU Histidine kinase OJF2_56310 ENOG4105CCT upf0313 protein OJF2_56380 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) OJF2_56390 ENOG4105C2J ABC transporter OJF2_56400 ENOG4105CNN ABC, transporter OJF2_56420 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) OJF2_56430 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) OJF2_56460 ENOG4107Y6J Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) OJF2_56470 ENOG4105EBR Carboxylesterase OJF2_56480 ENOG4105EMU Dehydrogenase OJF2_56500 ENOG4105DVY radical SAM domain protein OJF2_56550 ENOG4107RRE RNA-directed DNA polymerase OJF2_56560 ENOG4105D9P serine threonine protein kinase OJF2_56580 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase OJF2_56590 ENOG4105C5R Aminotransferase OJF2_56600 ENOG4108JQ1 Dehydrogenase OJF2_56610 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) OJF2_56620 ENOG4105KT7 mgtC SapB transporter OJF2_56630 ENOG4105C26 Dehydrogenase OJF2_56710 ENOG410902C phosphohistidine phosphatase, SixA OJF2_56750 ENOG4107QKG PfaD family OJF2_56760 ENOG4108JA1 polyketide synthase OJF2_56780 ENOG4105E2T synthase III OJF2_56790 ENOG4108J2P Alpha beta hydrolase fold OJF2_56800 ENOG410680H amp-dependent synthetase and ligase OJF2_56810 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase OJF2_56830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family OJF2_56840 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) OJF2_56850 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) OJF2_56860 ENOG4105C98 muts2 protein OJF2_56890 ENOG4107YK1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) OJF2_56900 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) OJF2_56920 ENOG4105E0R Deoxyhypusine synthase OJF2_56930 ENOG4108JEJ Pyruvoyl-dependent arginine decarboxylase OJF2_57030 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 OJF2_57050 ENOG4105BZ1 (ABC) transporter OJF2_57060 ENOG41061TZ Short-chain dehydrogenase reductase Sdr OJF2_57070 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin OJF2_57080 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) OJF2_57120 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) OJF2_57140 ENOG4105D7W serine acetyltransferase OJF2_57170 ENOG4105CHR reductase OJF2_57230 ENOG4105C01 Dihydroxy-acid dehydratase OJF2_57280 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) OJF2_57290 ENOG4105CPQ Dehydrogenase OJF2_57370 ENOG4105CEP NADH dehydrogenase OJF2_57380 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) OJF2_57390 ENOG4105C6V Glycerol-3-phosphate dehydrogenase OJF2_57450 ENOG4105ETE Transcriptional regulator (LacI family OJF2_57460 ENOG4108HKT sucrose-6-phosphate hydrolase OJF2_57480 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) OJF2_57520 ENOG4105CPC Aldo Keto reductase OJF2_57530 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_57540 ENOG4105BZU Histidine kinase OJF2_57550 ENOG410841Q phosphoesterase PA-phosphatase related protein OJF2_57580 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) OJF2_57710 ENOG41061TZ Short-chain dehydrogenase reductase Sdr OJF2_57760 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) OJF2_57780 ENOG4105C0H protease OJF2_57810 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) OJF2_57820 ENOG4105K46 50S ribosomal protein l27 OJF2_57830 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control OJF2_57850 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) OJF2_57870 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding OJF2_57890 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_57950 ENOG4105FE1 phytoene synthase OJF2_57960 ENOG4105FE1 phytoene synthase OJF2_58000 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) OJF2_58010 ENOG4108V06 Glutathione peroxidase OJF2_58070 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_58080 ENOG4105Y49 secretion protein, HlyD family OJF2_58130 ENOG4105DU6 RNA polymerase OJF2_58140 ENOG4105EMN RNA polymerase sigma factor OJF2_58150 ENOG4105D9P serine threonine protein kinase OJF2_58180 ENOG4105CNT hydrolase family 2 OJF2_58240 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving OJF2_58260 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) OJF2_58270 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) OJF2_58280 ENOG4105CG5 Glycosyl transferase (Group 1 OJF2_58290 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) OJF2_58330 ENOG4105C5T Phosphoribosyl pyrophosphate synthase OJF2_58350 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB OJF2_58380 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) OJF2_58390 ENOG4105C8T Leucyl-tRNA synthetase OJF2_58420 ENOG4106R49 Methyltransferase OJF2_58480 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha OJF2_58490 ENOG4105CMV Succinyl-CoA synthetase subunit beta OJF2_58530 ENOG4105CD3 dihydroorotase OJF2_58540 ENOG4105CXT aspartate transcarbamylase OJF2_58550 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) OJF2_58690 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 OJF2_58700 ENOG4105BZU Histidine kinase OJF2_58760 ENOG4107RUZ Sss sodium solute transporter superfamily OJF2_58790 ENOG4105E2K Glycosyl transferase (Group 1 OJF2_58810 ENOG4107VPB domain protein OJF2_58850 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) OJF2_58860 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) OJF2_58870 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) OJF2_58880 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) OJF2_58890 ENOG4105BZU Histidine kinase OJF2_58980 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) OJF2_58990 ENOG4105DZP Membrane-associated zinc metalloprotease OJF2_59030 ENOG4106633 50S ribosomal protein l28 OJF2_59040 ENOG41084CW 50S ribosomal protein L32 OJF2_59090 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) OJF2_59110 ENOG4107QHF type ii secretion system protein e OJF2_59140 ENOG4105XA0 heptosyltransferase ii OJF2_59150 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) OJF2_59250 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A OJF2_59260 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) OJF2_59280 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) OJF2_59290 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) OJF2_59320 ENOG4108V06 Glutathione peroxidase OJF2_59330 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase OJF2_59340 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain OJF2_59400 ENOG4105BZU Histidine kinase OJF2_59410 ENOG4105C3M thioredoxin reductase OJF2_59420 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) OJF2_59430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OJF2_59440 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) OJF2_59450 ENOG4105CH2 amidohydrolase OJF2_59520 ENOG4105CPK Glycosyl transferase (Group 1 OJF2_59620 ENOG4107QNG Phosphoribosylglycinamide synthetase OJF2_59740 ENOG4105D9P serine threonine protein kinase OJF2_59760 ENOG4105DZ0 fad dependent oxidoreductase OJF2_59810 ENOG4105E0F Histidine kinase OJF2_59820 ENOG4105E3W Two component transcriptional regulator (Winged helix family OJF2_59840 ENOG4105CKK Glycosyl transferase, family 2 OJF2_59850 ENOG4105EDW glycosyl transferase, family 39 OJF2_59920 ENOG4105CIK Amidinotransferase OJF2_59940 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) OJF2_59960 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_59980 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_60010 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase OJF2_60020 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) OJF2_60070 ENOG4108YYQ gCN5-related N-acetyltransferase OJF2_60080 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) OJF2_60090 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) OJF2_60100 ENOG4108Z40 Transcriptional regulator OJF2_60120 ENOG4105ENT Efflux transporter rnd family, mfp subunit OJF2_60180 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) OJF2_60240 ENOG4105C59 p-type ATPase OJF2_60310 ENOG4105C0H protease OJF2_60320 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) OJF2_60340 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) OJF2_60350 ENOG4108UJD 30S ribosomal protein S9 OJF2_60400 ENOG4105C9B Cysteine desulfurase OJF2_60410 ENOG4107YH3 SUF system FeS assembly protein, NifU family OJF2_60440 ENOG4105CIH Imidazole acetol-phosphate transaminase OJF2_60450 ENOG4105ECC imidazole-glycerol-phosphate dehydratase OJF2_60480 ENOG4105CUB amino acid OJF2_60510 ENOG4105BZ8 glutamate synthase OJF2_60520 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein OJF2_60540 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) OJF2_60550 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving OJF2_60590 ENOG4108P4C Formaldehyde-activating enzyme OJF2_60600 ENOG4108N1H methylenetetrahydrofolate dehydrogenase (NADP( OJF2_60630 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein OJF2_60660 ENOG4105CPC Aldo Keto reductase OJF2_60690 ENOG4105C3M thioredoxin reductase OJF2_60820 ENOG4105BZU Histidine kinase OJF2_60950 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) OJF2_60960 ENOG4105CJ1 ABC, transporter OJF2_60980 ENOG4105F0I Aminotransferase OJF2_61010 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) OJF2_61060 ENOG4107QPV Serine Threonine protein kinase OJF2_61070 ENOG4107JTW chlorite dismutase OJF2_61080 ENOG4108UHJ MAF-like protein OJF2_61090 ENOG4105DPZ Two component transcriptional regulator (Winged helix family OJF2_61140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) OJF2_61170 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_61200 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) OJF2_61210 ENOG4108JEZ rRNA small subunit methyltransferase G OJF2_61220 ENOG4105EPU Molybdenum cofactor synthesis domain protein OJF2_61240 ENOG4108UN4 phage SPO1 DNA polymerase-related protein OJF2_61250 ENOG4105BZU Histidine kinase OJF2_61290 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) OJF2_61310 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) OJF2_61360 ENOG4108WBT adenosyltransferase OJF2_61400 ENOG4108J2R molybdopterin oxidoreductase OJF2_61490 ENOG4105KTU Transcriptional regulator, arsr family OJF2_61520 ENOG4105D82 Glutamate dehydrogenase OJF2_61590 ENOG4105NPE arsR family transcriptional regulator OJF2_61660 ENOG4108VAU general secretion pathway protein G OJF2_61710 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) OJF2_61770 ENOG4105CHR reductase OJF2_61920 ENOG4105EMN RNA polymerase sigma factor OJF2_61940 ENOG4105CGD Nad-dependent epimerase dehydratase OJF2_61960 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) OJF2_61980 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) OJF2_62020 ENOG4105CBG Sulfatase OJF2_62120 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase OJF2_62160 ENOG4108UXN response regulator OJF2_62180 ENOG4105BZU Histidine kinase OJF2_62190 ENOG4105D9P serine threonine protein kinase OJF2_62200 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) OJF2_62210 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) OJF2_62230 ENOG4105NTK Transcriptional repressor Mpra OJF2_62270 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) OJF2_62280 ENOG4105C34 Pseudouridine synthase OJF2_62340 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) OJF2_62370 ENOG4108UYE Lactoylglutathione lyase OJF2_62430 ENOG4108IUZ ABC transporter OJF2_62440 ENOG4105C3F Signal peptidase i OJF2_62460 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) OJF2_62520 ENOG4105DND Transcriptional regulator OJF2_62530 ENOG4105D3R alkyl hydroperoxide reductase OJF2_62540 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) OJF2_62550 ENOG4105ETE Transcriptional regulator (LacI family OJF2_62560 ENOG4105C93 Xylose Isomerase OJF2_62570 ENOG41061MV Arylsulfatase OJF2_62580 ENOG4105D9P serine threonine protein kinase OJF2_62610 ENOG4105BZU Histidine kinase OJF2_62700 ENOG4105DKP glycosyl transferase, family 9 OJF2_62720 ENOG4105D9P serine threonine protein kinase OJF2_62770 ENOG4105D9P serine threonine protein kinase OJF2_62850 ENOG4105EPC oxidoreductase OJF2_62920 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) OJF2_62930 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) OJF2_62960 ENOG410857H Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) OJF2_62970 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) OJF2_63050 ENOG4105BZ1 (ABC) transporter OJF2_63140 ENOG4105C01 Dihydroxy-acid dehydratase OJF2_63160 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) OJF2_63180 ENOG4107RIQ Sulfate adenylate transferase OJF2_63320 ENOG4107TVC Glycosyl transferase, family 2 OJF2_63390 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) OJF2_63400 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) OJF2_63420 ENOG4105BZU Histidine kinase OJF2_63440 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) OJF2_63490 ENOG4105ETX regulatoR OJF2_63500 ENOG4105GR3 Histidine kinase OJF2_63520 ENOG4105DU6 RNA polymerase OJF2_63540 ENOG4105F0N pyrophosphate phospho-hydrolase OJF2_63570 ENOG4105CYN Serine protein kinase OJF2_63580 ENOG4106AKX UPF0229 protein OJF2_63600 ENOG4105ED1 spovr family OJF2_63670 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) OJF2_63680 ENOG4105CZX twitching motility protein OJF2_63690 ENOG4107QHF type ii secretion system protein e OJF2_63730 ENOG41085BB Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) OJF2_63740 ENOG4108RQS Two component transcriptional regulator (Winged helix family OJF2_63750 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase OJF2_63780 ENOG4105CAG UPF0210 protein OJF2_63830 ENOG4108JEH abc transporter atp-binding protein OJF2_63840 ENOG4105DRP amino acid AbC transporter OJF2_63870 ENOG4105D9P serine threonine protein kinase OJF2_63880 ENOG4105C54 Major Facilitator superfamily OJF2_63940 ENOG4105DFA alanine racemase domain protein OJF2_63950 ENOG4105VZ9 UPF0235 protein OJF2_63960 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase OJF2_64090 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) OJF2_64110 ENOG4105CPD ethanolamine ammonia-lyase OJF2_64130 ENOG4107FQ9 ethanolamine ammonia-lyase OJF2_64210 ENOG4105CE9 30S ribosomal protein S2 OJF2_64220 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) OJF2_64230 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) OJF2_64240 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) OJF2_64280 ENOG4107QQG Dehydrogenase OJF2_64300 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) OJF2_64330 ENOG4107R8N Glycosyl transferase, family 2 OJF2_64360 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) OJF2_64400 ENOG4105K64 Glycosyl transferase, family 2 OJF2_64480 ENOG4105D9R oxidoreductase OJF2_64550 ENOG4105K64 Glycosyl transferase, family 2 OJF2_64560 ENOG4105D3Q Sugar transferase OJF2_64660 ENOG4108V0P LemA family OJF2_64670 ENOG4105CQ7 ATP-dependent helicase OJF2_64690 ENOG4105D9P serine threonine protein kinase OJF2_64700 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) OJF2_64750 ENOG4105D9P serine threonine protein kinase OJF2_64800 ENOG4105DKQ ROK family OJF2_64810 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) OJF2_64900 ENOG4105BZ1 (ABC) transporter OJF2_64920 ENOG4105CPC Aldo Keto reductase OJF2_64970 ENOG41090A4 Pterin carbinolamine dehydratase OJF2_64980 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) OJF2_65010 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) OJF2_65020 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) OJF2_65070 ENOG4105C75 arginyL-tRNA synthetase OJF2_65120 ENOG4108UW5 maltose o-acetyltransferase OJF2_65350 ENOG4105CFG Acts as a chaperone (By similarity) OJF2_65360 ENOG4105CFG Acts as a chaperone (By similarity) OJF2_65410 ENOG4105EPW hflc protein OJF2_65420 ENOG4107RIZ hflk protein OJF2_65540 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_65580 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_65600 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) OJF2_65620 ENOG4105KBH arsR family transcriptional regulator OJF2_65630 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) OJF2_65640 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) OJF2_65660 ENOG4105D9P serine threonine protein kinase OJF2_65670 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) OJF2_65690 ENOG4105EUK rtx toxin RtxA OJF2_65720 ENOG4107RGD Major Facilitator superfamily OJF2_65750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OJF2_65760 ENOG4105BZU Histidine kinase OJF2_65770 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_65780 ENOG4105BZU Histidine kinase OJF2_65830 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) OJF2_65850 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_65860 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) OJF2_65870 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) OJF2_65880 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) OJF2_65940 ENOG4105DZG Dehydrogenase OJF2_66010 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) OJF2_66050 ENOG4105CHR reductase OJF2_66100 ENOG4105CQB FAD linked oxidase domain protein OJF2_66110 ENOG4105DIA mandelate racemase muconate lactonizing OJF2_66130 ENOG4108YYQ gCN5-related N-acetyltransferase OJF2_66150 ENOG4108KPJ rna polymerase sigma factor OJF2_66170 ENOG4105SYT Methylenetetrahydrofolate reductase OJF2_66180 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) OJF2_66220 ENOG4105C6T cysteine synthase OJF2_66230 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) OJF2_66300 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) OJF2_66320 ENOG4107TS3 membrane protein, TerC OJF2_66350 ENOG4105BZU Histidine kinase OJF2_66370 ENOG4105BZU Histidine kinase OJF2_66540 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) OJF2_66660 ENOG4105C0H protease OJF2_66670 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) OJF2_66750 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) OJF2_66760 ENOG4107RJ1 sodium solute OJF2_66770 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate OJF2_66780 ENOG4105RD7 BadF BadG BcrA BcrD OJF2_66900 ENOG4108IJF Heavy metal efflux pump, CzcA OJF2_66930 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate OJF2_66940 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) OJF2_66970 ENOG4105MA4 psp1 domain protein OJF2_66990 ENOG41067HS methyltransferase OJF2_67060 ENOG4105CKK Glycosyl transferase, family 2 OJF2_67100 ENOG4108IUX (ABC) transporter OJF2_67140 ENOG4105MVF Transcriptional regulator OJF2_67150 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system OJF2_67160 ENOG4105CTQ phosphohexokinase OJF2_67210 ENOG4105DFH Transport of potassium into the cell (By similarity) OJF2_67240 ENOG4107YHX fad dependent oxidoreductase OJF2_67250 ENOG4105W5Z OJF2_67400 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) OJF2_67410 ENOG4105C11 sulfate adenylyltransferase), subunit 2 OJF2_67430 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) OJF2_67460 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) OJF2_67560 ENOG4105CTX dehydratase OJF2_67570 ENOG4107QHF type ii secretion system protein e OJF2_67580 ENOG4105CZX twitching motility protein OJF2_67590 ENOG4107QHF type ii secretion system protein e OJF2_67600 ENOG4105D7Q type ii secretion system OJF2_67670 ENOG4106855 Competence protein OJF2_67710 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) OJF2_67730 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) OJF2_67740 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) OJF2_67830 ENOG4105BZU Histidine kinase OJF2_67920 ENOG4105C5I Dehydrogenase OJF2_67970 ENOG4105DDQ anthranilate synthase OJF2_67980 ENOG4105CVM Molybdenum cofactor synthesis domain protein OJF2_67990 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) OJF2_68030 ENOG4105DFS Conserved Protein OJF2_68040 ENOG4105C1P efflux transporter, rnd family, mfp subunit OJF2_68080 ENOG4105DEN Luciferase family OJF2_68120 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) OJF2_68170 ENOG4105EMN RNA polymerase sigma factor OJF2_68200 ENOG4105DUM transcriptional regulator, lysR family OJF2_68230 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) OJF2_68260 ENOG4105D9P serine threonine protein kinase OJF2_68300 ENOG4105C6W 4-alpha-glucanotransferase (EC 2.4.1.25) OJF2_68330 ENOG4107S9D Alpha beta hydrolase OJF2_68340 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) OJF2_68350 ENOG4108WBH protein TIM barrel OJF2_68390 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) OJF2_68420 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) OJF2_68430 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) OJF2_68460 ENOG41080SX Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) OJF2_68470 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase OJF2_68520 ENOG4105VT3 DNA binding domain protein, excisionase family OJF2_68540 ENOG4105CH2 amidohydrolase OJF2_68580 ENOG4105C8Q Methyl-accepting chemotaxis OJF2_68590 ENOG4105CBS Chea signal transduction histidine kinase OJF2_68600 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase OJF2_68630 ENOG4105E6M Sulphatase-modifying factor protein OJF2_68680 ENOG4105CIG ABC transporter OJF2_68690 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) OJF2_68700 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) OJF2_68740 ENOG4108HKT sucrose-6-phosphate hydrolase OJF2_68750 ENOG4107QNK )-transporter OJF2_68760 ENOG4108RVA ribokinase OJF2_68780 ENOG4107TE5 Lipid kinase OJF2_68790 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_68860 ENOG4105CK2 sodium dicarboxylate symporter OJF2_68890 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) OJF2_68920 ENOG41080R2 UPF0102 protein OJF2_69010 ENOG4105DC7 peptidase M24 OJF2_69030 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase OJF2_69120 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OJF2_69200 ENOG4105C59 p-type ATPase OJF2_69240 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) OJF2_69320 ENOG4105CPK Glycosyl transferase (Group 1 OJF2_69370 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit OJF2_69380 ENOG4105CFG Acts as a chaperone (By similarity) OJF2_69410 ENOG4105CQC Prephenate dehydratase OJF2_69480 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) OJF2_69500 ENOG4105DSF transport protein OJF2_69580 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) OJF2_69590 ENOG4105EPD Oligopeptide transporter, Opt family OJF2_69600 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) OJF2_69610 ENOG4105CVJ phosphoglycerate mutase OJF2_69620 ENOG4105CNU cell division protein FtsK OJF2_69630 ENOG41063B5 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) OJF2_69640 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) OJF2_69650 ENOG4105DSJ YicC domain protein OJF2_69670 ENOG4105CP7 Triose-phosphate isomerase OJF2_69680 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase OJF2_69740 ENOG4105D9R oxidoreductase OJF2_69830 ENOG4107QZ7 Cellulose synthase catalytic subunit OJF2_69870 ENOG4105CN1 protease OJF2_69990 ENOG4105CUX Signal transduction histidine kinase OJF2_70090 ENOG4105BZU Histidine kinase OJF2_70100 ENOG4105BZ1 (ABC) transporter OJF2_70110 ENOG4105BZ1 (ABC) transporter OJF2_70120 ENOG4105DJB Major Facilitator Superfamily OJF2_70130 ENOG4105CXK mandelate racemase muconate lactonizing OJF2_70220 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) OJF2_70240 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) OJF2_70280 ENOG4108RWI nicotinamidase OJF2_70300 ENOG4107SGM protein serine threonine phosphatase OJF2_70310 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein OJF2_70530 ENOG4105D9P serine threonine protein kinase OJF2_70590 ENOG4105E0F Histidine kinase OJF2_70600 ENOG4105E3W Two component transcriptional regulator (Winged helix family OJF2_70640 ENOG4105D9P serine threonine protein kinase OJF2_70660 ENOG4105D9P serine threonine protein kinase OJF2_70710 ENOG4105M7K Involved in the transcription termination process (By similarity) OJF2_70720 ENOG4105DB7 PHP domain protein OJF2_70760 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_70820 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OJF2_70840 ENOG4105EM7 Selenocysteine-specific translation elongation factor OJF2_70850 ENOG4105DZ1 carboxypeptidase OJF2_70870 ENOG4105CHR reductase OJF2_70920 ENOG4105D9P serine threonine protein kinase OJF2_70970 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein OJF2_70990 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) OJF2_71030 ENOG4105M7V 2'-5' rna ligase OJF2_71040 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) OJF2_71060 ENOG4108DT4 serine threonine protein kinase OJF2_71100 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase OJF2_71110 ENOG4105C8V SAICAR synthetase OJF2_71150 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) OJF2_71180 ENOG4105ETE Transcriptional regulator (LacI family OJF2_71190 ENOG4105DSG hydrolase family 43 OJF2_71300 ENOG4105C1P efflux transporter, rnd family, mfp subunit OJF2_71380 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit OJF2_71390 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding OJF2_71400 ENOG4105C7W Xanthine dehydrogenase OJF2_71440 ENOG4107JEE Short-chain dehydrogenase reductase Sdr OJF2_71450 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) OJF2_71490 ENOG4107WAU Protein tyrosine phosphatase OJF2_71500 ENOG4105E2X shikimate dehydrogenase OJF2_71550 ENOG4105G47 Methyltransferase, type 11 OJF2_71600 ENOG4105K64 Glycosyl transferase, family 2 OJF2_71870 ENOG4105C2C drug resistance transporter, Bcr CflA OJF2_71910 ENOG4105EMN RNA polymerase sigma factor OJF2_71940 ENOG4108IND Tetr family transcriptional regulator OJF2_71970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase OJF2_72010 ENOG4105FQP Beta-lactamase OJF2_72040 ENOG4105DU6 RNA polymerase OJF2_72050 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) OJF2_72060 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) OJF2_72070 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) OJF2_72110 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) OJF2_72120 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) OJF2_72200 ENOG410600T transposase OJF2_72290 ENOG4105CMM transposase OJF2_72350 ENOG4105CTD carboxy-peptidase OJF2_72740 ENOG4108UT2 hemolysin iii OJF2_72820 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) OJF2_72890 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_72920 ENOG4105K4I Scp-like extracellular OJF2_72950 ENOG4105D9P serine threonine protein kinase OJF2_73000 ENOG4105KHC sulfurtransferase OJF2_73010 ENOG4105D9P serine threonine protein kinase OJF2_73050 ENOG4105CZX twitching motility protein OJF2_73210 ENOG4108HKT sucrose-6-phosphate hydrolase OJF2_73220 ENOG4105DKG l-rhamnose isomerase OJF2_73250 ENOG4105BZU Histidine kinase OJF2_73260 ENOG4105BZU Histidine kinase OJF2_73290 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_73310 ENOG4105D9P serine threonine protein kinase OJF2_73370 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein OJF2_73410 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) OJF2_73450 ENOG4105CQM Urea amidohydrolase subunit alpha OJF2_73460 ENOG4105KI2 Urea amidohydrolase subunit beta OJF2_73470 ENOG4108YZ9 Urea amidohydrolase subunit gamma OJF2_73510 ENOG4105DHF Membrane OJF2_73530 ENOG4105CSA Coproporphyrinogen iii oxidase OJF2_73680 ENOG4105EMN RNA polymerase sigma factor OJF2_73730 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr OJF2_73830 ENOG4105VN1 Heat shock protein OJF2_73840 ENOG4105VN1 Heat shock protein OJF2_73980 ENOG4105C9U ATP-dependent DNA helicase RecQ OJF2_74020 ENOG4105E6M Sulphatase-modifying factor protein OJF2_74060 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) OJF2_74130 ENOG4105CIH Imidazole acetol-phosphate transaminase OJF2_74210 ENOG4105D8X mechanosensitive ion channel OJF2_74380 ENOG4105EXU Membrane OJF2_74400 ENOG4105BZU Histidine kinase OJF2_74620 ENOG4105C08 Histidine kinase OJF2_74630 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) OJF2_74650 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) OJF2_74670 ENOG4108ZXC Two component transcriptional regulator, luxr family OJF2_74680 ENOG4105ES5 Histidine kinase OJF2_74700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_74780 ENOG4105C0R drug resistance transporter emrb qaca subfamily OJF2_74790 ENOG4105CW7 secretion protein, HlyD family OJF2_74820 ENOG4105E2V Glycosyltransferase 36 OJF2_74850 ENOG4105C0H protease OJF2_74880 ENOG4108QBV Monogalactosyldiacylglycerol synthase OJF2_74930 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) OJF2_74950 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A OJF2_74980 ENOG4105F0F Oxalate decarboxylase OJF2_75120 ENOG4108KN0 Choline kinase OJF2_75150 ENOG4105E6M Sulphatase-modifying factor protein OJF2_75430 ENOG4107QR8 Thioredoxin OJF2_75450 ENOG4105DJV ribulose-phosphate 3-epimerase OJF2_75580 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) OJF2_75690 ENOG4105C0I Conserved Protein OJF2_75700 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase OJF2_75850 ENOG4105CQR helicase OJF2_75910 ENOG4105EB2 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) OJF2_75940 ENOG4105CJ3 phosphate transporter OJF2_76000 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic OJF2_76100 ENOG41089UC methyltransferase, type 11 OJF2_76140 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) OJF2_76150 ENOG4108R6K riboflavin synthase, subunit alpha OJF2_76190 ENOG4107QN2 dihydrolipoyl dehydrogenase OJF2_76250 ENOG4105BZU Histidine kinase OJF2_76310 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) OJF2_76350 ENOG4105C0H protease OJF2_76400 ENOG4105CPC Aldo Keto reductase OJF2_76410 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) OJF2_76430 ENOG4108ZFD Antibiotic biosynthesis monooxygenase OJF2_76440 ENOG4107QUY Guanine deaminase OJF2_76460 ENOG4105C7W Xanthine dehydrogenase OJF2_76490 ENOG4105CHR reductase OJF2_76600 ENOG4105DGI Alkaline phosphatase OJF2_76710 ENOG4105EMN RNA polymerase sigma factor OJF2_76750 ENOG410827H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) OJF2_76790 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) OJF2_76900 ENOG4105D9P serine threonine protein kinase OJF2_76940 ENOG4105DU6 RNA polymerase OJF2_77040 ENOG4105BZU Histidine kinase OJF2_77170 ENOG4107BJW polysaccharide deacetylase OJF2_77190 ENOG4105DIN metallophosphoesterase OJF2_77200 ENOG4105EMN RNA polymerase sigma factor OJF2_77210 ENOG4105D9P serine threonine protein kinase OJF2_77300 ENOG4105ENH Sulfatase OJF2_77350 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone OJF2_77360 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) OJF2_77410 ENOG4107FQX Alpha-acetolactate decarboxylase OJF2_77430 ENOG4105C7K acetolactate synthase OJF2_77480 ENOG4105C0R drug resistance transporter emrb qaca subfamily OJF2_77490 ENOG4105CW7 secretion protein, HlyD family OJF2_77550 ENOG4105CIG ABC transporter OJF2_77590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) OJF2_77660 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) OJF2_77680 ENOG4108PBA serine threonine protein kinase OJF2_77780 ENOG4105C0D helicase OJF2_77790 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) OJF2_77810 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) OJF2_77830 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) OJF2_77950 ENOG4105D9P serine threonine protein kinase OJF2_78240 ENOG4105C0H protease OJF2_78250 ENOG4107QJE Chromosome Partitioning Protein OJF2_78290 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) OJF2_78310 ENOG4105D3Q Sugar transferase OJF2_78330 ENOG4105EY8 ABC transporter OJF2_78350 ENOG4107TYG Oxidoreductase domain-containing protein OJF2_78370 ENOG4105CEY Amp-dependent synthetase and ligase OJF2_78390 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase OJF2_78410 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase OJF2_78430 ENOG4107T8Q Glycosyl transferase (Group 1 OJF2_78520 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) OJF2_78530 ENOG4107QK4 glycoside hydrolase, family 3 domain protein OJF2_78600 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) OJF2_78630 ENOG4105K6V RNA polymerase OJF2_78660 ENOG4105NA0 Transcriptional regulator OJF2_78690 ENOG4105E2V Glycosyltransferase 36 OJF2_78710 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) OJF2_78720 ENOG4105W8H transhydrogenase (subunit alpha OJF2_78730 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) OJF2_78740 ENOG4105C08 Histidine kinase OJF2_78760 ENOG4105EHU Circadian clock protein KaiC OJF2_78870 ENOG4105CF7 AraC family transcriptional regulator OJF2_78910 ENOG4105CPC Aldo Keto reductase OJF2_78980 ENOG4108DT4 serine threonine protein kinase OJF2_79010 ENOG4107SFQ iron-sulfur binding OJF2_79100 ENOG4105CCU oxidase (Subunit III) OJF2_79130 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OJF2_79200 ENOG4107QJE Chromosome Partitioning Protein OJF2_79320 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) OJF2_79370 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OJF2_79480 ENOG4105BZU Histidine kinase