locus-tag	class	description
D6B99_00035	COG1007	ATP synthesis coupled electron transport
D6B99_00040	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6B99_00045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D6B99_00050	COG0713	ATP synthesis coupled electron transport
D6B99_00055	COG0839	Belongs to the complex I subunit 6 family
D6B99_00060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6B99_00065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D6B99_00070	COG1034	ATP synthesis coupled electron transport
D6B99_00080	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D6B99_00095	COG0649	NAD binding
D6B99_00105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6B99_00110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6B99_00115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D6B99_00120	COG0215	cysteine-tRNA ligase activity
D6B99_00125	COG3511	phospholipase C
D6B99_00140	COG2217	Heavy metal translocating P-type atpase
D6B99_00150	COG0686	Belongs to the AlaDH PNT family
D6B99_00180	COG0768	penicillin binding
D6B99_00185	COG0772	Belongs to the SEDS family
D6B99_00190	COG0598	Magnesium transport protein CorA
D6B99_00195	COG1760	l-serine dehydratase
D6B99_00205	COG0436	Aminotransferase
D6B99_00210	COG0509	glycine decarboxylation via glycine cleavage system
D6B99_00215	COG0335	large ribosomal subunit rRNA binding
D6B99_00225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D6B99_00240	COG2235	arginine
D6B99_00280	COG3335	DDE superfamily endonuclease
D6B99_00295	COG1199	ATP-dependent helicase activity
D6B99_00295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D6B99_00305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D6B99_00330	COG0084	hydrolase, TatD family'
D6B99_00335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D6B99_00345	COG1011	Hydrolase
D6B99_00355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D6B99_00360	COG1612	heme a metabolic process
D6B99_00365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D6B99_00380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D6B99_00385	COG1131	(ABC) transporter
D6B99_00390	COG1956	GAF domain-containing protein
D6B99_00395	COG3279	Response regulator of the LytR AlgR family
D6B99_00400	COG3275	phosphorelay sensor kinase activity
D6B99_00405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D6B99_00410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D6B99_00425	COG1418	mRNA catabolic process
D6B99_00440	COG3959	Transketolase, thiamine diphosphate binding domain
D6B99_00445	COG0233	cytoplasmic translational termination
D6B99_00450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D6B99_00455	COG0126	phosphoglycerate kinase activity
D6B99_00460	COG1764	response to oxidative stress
D6B99_00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6B99_00475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6B99_00485	COG1214	PFAM Peptidase M22, glycoprotease
D6B99_00490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D6B99_00500	COG0437	4 iron, 4 sulfur cluster binding
D6B99_00525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D6B99_00530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D6B99_00535	COG0109	protoheme IX farnesyltransferase activity
D6B99_00540	COG1845	cytochrome c oxidase, subunit III
D6B99_00545	COG1845	cytochrome c oxidase, subunit III
D6B99_00555	COG1999	signal sequence binding
D6B99_00560	COG2322	membrane
D6B99_00570	COG4206	TonB-dependent receptor
D6B99_00570	COG1629	transport
D6B99_00585	COG3275	phosphorelay sensor kinase activity
D6B99_00595	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_00600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D6B99_00605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D6B99_00610	COG1162	GTPase activity
D6B99_00630	COG1138	Cytochrome C-type biogenesis protein
D6B99_00645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6B99_00650	COG2304	oxidoreductase activity
D6B99_00660	COG4771	TonB-dependent receptor
D6B99_00670	COG1522	sequence-specific DNA binding
D6B99_00685	COG3335	DDE superfamily endonuclease
D6B99_00700	COG4680	protein conserved in bacteria
D6B99_00710	COG0805	protein transport
D6B99_00715	COG0604	alcohol dehydrogenase
D6B99_00720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D6B99_00740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D6B99_00760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_00770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D6B99_00785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D6B99_00790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D6B99_00805	COG0724	RNA recognition motif
D6B99_00810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6B99_00815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D6B99_00825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D6B99_00825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D6B99_00830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D6B99_00845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D6B99_00880	COG0824	Thioesterase
D6B99_00905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D6B99_00910	COG0433	COG0433 Predicted ATPase
D6B99_00920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D6B99_00945	COG0321	lipoyl(octanoyl) transferase activity
D6B99_00950	COG4771	TonB-dependent receptor
D6B99_00955	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D6B99_00960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D6B99_00965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D6B99_00970	COG0006	proline dipeptidase activity
D6B99_00985	COG1183	phosphatidylcholine synthase activity
D6B99_00995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D6B99_01005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D6B99_01015	COG0328	RNA-DNA hybrid ribonuclease activity
D6B99_01045	COG0288	reversible hydration of carbon dioxide
D6B99_01050	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_01080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D6B99_01085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6B99_01105	COG0336	Belongs to the RNA methyltransferase TrmD family
D6B99_01115	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D6B99_01180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D6B99_01190	COG0101	tRNA pseudouridine synthase activity
D6B99_01220	COG3345	alpha-galactosidase
D6B99_01225	COG0357	Ribosomal RNA small subunit methyltransferase G
D6B99_01235	COG0504	CTP synthase activity
D6B99_01240	COG1960	acyl-CoA dehydrogenase activity
D6B99_01265	COG1368	sulfuric ester hydrolase activity
D6B99_01335	COG4771	TonB-dependent receptor
D6B99_01415	COG0464	growth
D6B99_01420	COG1404	Belongs to the peptidase S8 family
D6B99_01445	COG1132	(ABC) transporter
D6B99_01460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D6B99_01465	COG0165	Argininosuccinate lyase
D6B99_01470	COG3265	gluconokinase activity
D6B99_01475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6B99_01480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D6B99_01500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D6B99_01505	COG0137	argininosuccinate synthase activity
D6B99_01520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D6B99_01535	COG2226	methyltransferase
D6B99_01540	COG0714	Associated with various cellular activities
D6B99_01560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D6B99_01575	COG0860	N-Acetylmuramoyl-L-alanine amidase
D6B99_01580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D6B99_01585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D6B99_01590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D6B99_01620	COG1940	carbohydrate kinase activity
D6B99_01625	COG0738	Major facilitator superfamily
D6B99_01630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D6B99_01635	COG3023	N-Acetylmuramoyl-L-alanine amidase
D6B99_01640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6B99_01650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D6B99_01660	COG3119	arylsulfatase activity
D6B99_01675	COG1649	PFAM Uncharacterised BCR, COG1649
D6B99_01690	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D6B99_01690	COG0662	Cupin 2, conserved barrel domain protein
D6B99_01695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6B99_01700	COG3119	arylsulfatase activity
D6B99_01705	COG3119	arylsulfatase activity
D6B99_01710	COG1024	Enoyl-CoA hydratase
D6B99_01720	COG0372	Belongs to the citrate synthase family
D6B99_01725	COG2079	MmgE PrpD family protein
D6B99_01735	COG1960	acyl-CoA dehydrogenase activity
D6B99_01760	COG1629	transport
D6B99_01770	COG4206	TonB-dependent receptor
D6B99_01770	COG1629	transport
D6B99_01805	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_01810	COG5520	Belongs to the glycosyl hydrolase 30 family
D6B99_01850	COG3335	DDE superfamily endonuclease
D6B99_01865	COG2963	transposase activity
D6B99_01875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D6B99_01885	COG1086	Polysaccharide biosynthesis protein
D6B99_01895	COG0251	oxidation-reduction process
D6B99_01905	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
D6B99_01945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D6B99_01970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6B99_01975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D6B99_01980	COG0149	triose-phosphate isomerase activity
D6B99_01985	COG0322	excinuclease ABC activity
D6B99_02010	COG1331	Highly conserved protein containing a thioredoxin domain
D6B99_02015	COG1660	Displays ATPase and GTPase activities
D6B99_02020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D6B99_02025	COG0511	ligase activity, forming carbon-carbon bonds
D6B99_02030	COG0439	Biotin carboxylase
D6B99_02035	COG2732	(Barnase) inhibitor
D6B99_02045	COG1454	alcohol dehydrogenase
D6B99_02055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D6B99_02085	COG1917	Cupin 2, conserved barrel domain protein
D6B99_02085	COG2207	Transcriptional regulator
D6B99_02100	COG1132	(ABC) transporter
D6B99_02105	COG1132	(ABC) transporter
D6B99_02120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D6B99_02130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D6B99_02145	COG3250	beta-galactosidase activity
D6B99_02155	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D6B99_02175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D6B99_02180	COG2910	NAD(P)H-binding
D6B99_02205	COG1194	a g-specific adenine glycosylase
D6B99_02215	COG4555	ABC transporter
D6B99_02225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D6B99_02235	COG0542	response to heat
D6B99_02245	COG2211	Major facilitator Superfamily
D6B99_02250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D6B99_02255	COG0297	glycogen (starch) synthase activity
D6B99_02265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D6B99_02270	COG0196	riboflavin kinase activity
D6B99_02275	COG1132	(ABC) transporter
D6B99_02280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D6B99_02320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D6B99_02325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D6B99_02335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D6B99_02340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D6B99_02350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D6B99_02370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D6B99_02395	COG0481	GTPase activity
D6B99_02405	COG1349	DNA-binding transcription factor activity
D6B99_02410	COG0300	oxidoreductase activity
D6B99_02415	COG1609	Transcriptional regulator
D6B99_02415	COG2207	Transcriptional regulator
D6B99_02425	COG3177	Filamentation induced by cAMP protein fic
D6B99_02460	COG1741	Belongs to the pirin family
D6B99_02465	COG2130	NADP-dependent
D6B99_02475	COG4221	oxidoreductase activity
D6B99_02490	COG2814	Major facilitator Superfamily
D6B99_02495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D6B99_02500	COG0799	negative regulation of ribosome biogenesis
D6B99_02510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6B99_02515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_02520	COG1047	Peptidyl-prolyl cis-trans
D6B99_02525	COG0564	pseudouridine synthase activity
D6B99_02530	COG4771	TonB-dependent receptor
D6B99_02570	COG1765	OsmC-like protein
D6B99_02590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D6B99_02600	COG0488	(ABC) transporter
D6B99_02610	COG0157	Belongs to the NadC ModD family
D6B99_02615	COG0023	Translation Initiation Factor
D6B99_02625	COG1473	amidohydrolase
D6B99_02630	COG0281	malic enzyme
D6B99_02630	COG0280	phosphate acetyltransferase
D6B99_02635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D6B99_02640	COG0492	ferredoxin-NADP+ reductase activity
D6B99_02645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D6B99_02650	COG3335	DDE superfamily endonuclease
D6B99_02660	COG0513	Belongs to the DEAD box helicase family
D6B99_02675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D6B99_02730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D6B99_02730	COG0519	Catalyzes the synthesis of GMP from XMP
D6B99_02740	COG0268	Binds directly to 16S ribosomal RNA
D6B99_02750	COG0567	Dehydrogenase, E1 component
D6B99_02755	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6B99_02770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D6B99_02780	COG1862	Preprotein translocase
D6B99_02805	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D6B99_02805	COG1796	DNA polymerase
D6B99_02810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D6B99_02815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D6B99_02820	COG0363	glucosamine-6-phosphate deaminase activity
D6B99_02830	COG1053	succinate dehydrogenase
D6B99_02835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D6B99_02845	COG4974	Belongs to the 'phage' integrase family
D6B99_02850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D6B99_02860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D6B99_02880	COG0545	Peptidyl-prolyl cis-trans isomerase
D6B99_02900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D6B99_02915	COG0514	ATP-dependent DNA helicase (RecQ)
D6B99_02920	COG0004	ammonium transporteR
D6B99_02925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D6B99_02940	COG1803	Methylglyoxal synthase
D6B99_02965	COG0183	Belongs to the thiolase family
D6B99_02970	COG3264	Mechanosensitive ion channel
D6B99_02970	COG1196	nuclear chromosome segregation
D6B99_02975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D6B99_02990	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D6B99_02995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D6B99_03030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D6B99_03060	COG4221	oxidoreductase activity
D6B99_03065	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_03070	COG3250	beta-galactosidase activity
D6B99_03080	COG1609	Transcriptional regulator
D6B99_03085	COG1904	glucuronate isomerase
D6B99_03095	COG2731	YhcH YjgK YiaL family protein
D6B99_03100	COG0800	Aldolase
D6B99_03105	COG2271	Major facilitator Superfamily
D6B99_03110	COG2755	lipolytic protein G-D-S-L family
D6B99_03110	COG0657	acetylesterase activity
D6B99_03115	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_03120	COG1312	Catalyzes the dehydration of D-mannonate
D6B99_03125	COG2095	MarC family integral membrane protein
D6B99_03135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D6B99_03140	COG0259	pyridoxamine-phosphate oxidase activity
D6B99_03155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D6B99_03160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D6B99_03165	COG1185	polyribonucleotide nucleotidyltransferase activity
D6B99_03205	COG0557	exoribonuclease II activity
D6B99_03210	COG1663	tetraacyldisaccharide 4'-kinase activity
D6B99_03215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D6B99_03230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D6B99_03235	COG1393	Belongs to the ArsC family
D6B99_03245	COG0424	maF-like protein
D6B99_03270	COG1132	(ABC) transporter
D6B99_03285	COG1666	GTP binding
D6B99_03305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D6B99_03320	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D6B99_03330	COG0179	Fumarylacetoacetate (FAA) hydrolase
D6B99_03335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D6B99_03345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D6B99_03355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D6B99_03370	COG3275	phosphorelay sensor kinase activity
D6B99_03375	COG3279	Response regulator of the LytR AlgR family
D6B99_03395	COG0783	Belongs to the Dps family
D6B99_03410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_03415	COG0436	Aminotransferase
D6B99_03425	COG0778	Nitroreductase
D6B99_03430	COG1271	oxidase subunit
D6B99_03445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D6B99_03485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6B99_03490	COG2815	serine threonine protein kinase
D6B99_03490	COG0515	serine threonine protein kinase
D6B99_03495	COG1181	Belongs to the D-alanine--D-alanine ligase family
D6B99_03500	COG0708	Exodeoxyribonuclease III
D6B99_03510	COG0776	regulation of translation
D6B99_03520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D6B99_03525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D6B99_03530	COG1418	mRNA catabolic process
D6B99_03550	COG0012	GTP binding
D6B99_03560	COG0700	Nucleoside recognition
D6B99_03585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D6B99_03590	COG1609	Transcriptional regulator
D6B99_03605	COG2166	iron-sulfur cluster assembly
D6B99_03610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D6B99_03615	COG0719	Fe-S assembly protein
D6B99_03620	COG0396	ATPase activity
D6B99_03625	COG0719	Fe-S assembly protein
D6B99_03630	COG0316	Belongs to the HesB IscA family
D6B99_03650	COG2321	neutral zinc metallopeptidase
D6B99_03655	COG4221	oxidoreductase activity
D6B99_03670	COG0205	6-phosphofructokinase activity
D6B99_03685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D6B99_03690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D6B99_03695	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D6B99_03700	COG1132	(ABC) transporter
D6B99_03705	COG0363	glucosamine-6-phosphate deaminase activity
D6B99_03710	COG0519	Catalyzes the synthesis of GMP from XMP
D6B99_03715	COG1584	GPR1 FUN34 yaaH family protein
D6B99_03725	COG0488	(ABC) transporter
D6B99_03735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D6B99_03740	COG2153	protein acetylation
D6B99_03770	COG0583	DNA-binding transcription factor activity
D6B99_03775	COG2855	membrane
D6B99_03785	COG2986	histidine ammonia-lyase
D6B99_03820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D6B99_03845	COG0717	Belongs to the dCTP deaminase family
D6B99_03860	COG2154	pterin-4-alpha-carbinolamine dehydratase
D6B99_03865	COG0589	response to stress
D6B99_03875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D6B99_03880	COG0038	chloride channel
D6B99_03910	COG0702	epimerase
D6B99_03915	COG1629	transport
D6B99_03920	COG5520	Belongs to the glycosyl hydrolase 30 family
D6B99_03925	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_03945	COG1595	DNA-templated transcription, initiation
D6B99_03955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D6B99_03955	COG0321	lipoyl(octanoyl) transferase activity
D6B99_03970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D6B99_03985	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6B99_03990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D6B99_04005	COG0440	acetolactate synthase activity
D6B99_04010	COG0028	Belongs to the TPP enzyme family
D6B99_04020	COG2226	methyltransferase
D6B99_04025	COG0473	3-isopropylmalate dehydrogenase activity
D6B99_04030	COG1119	ATPase activity
D6B99_04035	COG4106	trans-aconitate 2-methyltransferase activity
D6B99_04040	COG0066	3-isopropylmalate dehydratase activity
D6B99_04045	COG4106	trans-aconitate 2-methyltransferase activity
D6B99_04050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D6B99_04055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D6B99_04065	COG0069	glutamate synthase activity
D6B99_04070	COG0028	Belongs to the TPP enzyme family
D6B99_04075	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D6B99_04085	COG0527	aspartate kinase activity
D6B99_04090	COG1131	(ABC) transporter
D6B99_04100	COG0494	nUDIX hydrolase
D6B99_04110	COG0531	amino acid
D6B99_04120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D6B99_04125	COG2204	response regulator
D6B99_04140	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D6B99_04145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D6B99_04165	COG0248	Ppx GppA phosphatase
D6B99_04170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D6B99_04175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D6B99_04175	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D6B99_04180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D6B99_04185	COG2171	N-acyltransferase activity
D6B99_04200	COG0306	phosphate transporter
D6B99_04205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D6B99_04210	COG3958	Transketolase
D6B99_04215	COG1595	DNA-templated transcription, initiation
D6B99_04235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D6B99_04245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D6B99_04250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D6B99_04255	COG1739	Uncharacterized protein family UPF0029
D6B99_04260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D6B99_04260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D6B99_04270	COG1381	Involved in DNA repair and RecF pathway recombination
D6B99_04295	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D6B99_04300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D6B99_04355	COG0527	aspartate kinase activity
D6B99_04365	COG2239	Acts as a magnesium transporter
D6B99_04370	COG3335	DDE superfamily endonuclease
D6B99_04385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D6B99_04390	COG0573	inorganic phosphate transmembrane transporter activity
D6B99_04395	COG0581	inorganic phosphate transmembrane transporter activity
D6B99_04400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D6B99_04415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D6B99_04420	COG0813	purine-nucleoside phosphorylase activity
D6B99_04430	COG2890	protein-(glutamine-N5) methyltransferase activity
D6B99_04445	COG4166	transmembrane transport
D6B99_04465	COG0517	IMP dehydrogenase activity
D6B99_04465	COG0516	GMP reductase activity
D6B99_04475	COG3177	Filamentation induced by cAMP protein fic
D6B99_04500	COG0579	oxidoreductase
D6B99_04520	COG0756	dUTP diphosphatase activity
D6B99_04525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D6B99_04530	COG0167	dihydroorotate dehydrogenase activity
D6B99_04545	COG1983	PspC domain protein
D6B99_04550	COG1695	Transcriptional regulator
D6B99_04560	COG0124	histidyl-tRNA synthetase
D6B99_04570	COG0247	lactate metabolic process
D6B99_04575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D6B99_04585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D6B99_04595	COG1435	thymidine kinase activity
D6B99_04610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D6B99_04635	COG2003	Belongs to the UPF0758 family
D6B99_04640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D6B99_04645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D6B99_04680	COG0360	Binds together with S18 to 16S ribosomal RNA
D6B99_04685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D6B99_04690	COG0359	binds to the 23S rRNA
D6B99_04715	COG0793	Belongs to the peptidase S41A family
D6B99_04730	COG1674	ftsk spoiiie
D6B99_04740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D6B99_04745	COG3275	phosphorelay sensor kinase activity
D6B99_04750	COG3279	Response regulator of the LytR AlgR family
D6B99_04765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6B99_04785	COG3344	reverse transcriptase
D6B99_04795	COG0436	Aminotransferase
D6B99_04800	COG0287	Prephenate dehydrogenase
D6B99_04805	COG0513	Belongs to the DEAD box helicase family
D6B99_04810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D6B99_04820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D6B99_04825	COG1830	Aldolase
D6B99_04835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D6B99_04840	COG0590	tRNA wobble adenosine to inosine editing
D6B99_04845	COG3590	peptidase
D6B99_04860	COG0531	amino acid
D6B99_04865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D6B99_04870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D6B99_04880	COG1252	NADH dehydrogenase
D6B99_04905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D6B99_04910	COG1160	GTP binding
D6B99_04915	COG0671	phosphoesterase, PA-phosphatase related
D6B99_04920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D6B99_04930	COG0494	nUDIX hydrolase
D6B99_04945	COG3328	transposase activity
D6B99_04950	COG4804	nuclease activity
D6B99_04960	COG0706	membrane insertase activity
D6B99_04975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D6B99_04990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D6B99_05000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D6B99_05005	COG0531	amino acid
D6B99_05010	COG1301	dicarboxylic acid transport
D6B99_05015	COG0586	Pfam SNARE associated Golgi protein
D6B99_05020	COG0180	Tryptophanyl-tRNA synthetase
D6B99_05025	COG1428	Deoxynucleoside kinase
D6B99_05035	COG4948	Mandelate Racemase Muconate Lactonizing
D6B99_05040	COG1609	Transcriptional regulator
D6B99_05045	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D6B99_05050	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_05055	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D6B99_05070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D6B99_05070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D6B99_05095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D6B99_05100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D6B99_05105	COG0825	malonyl-CoA metabolic process
D6B99_05135	COG2207	Transcriptional regulator
D6B99_05135	COG1917	Cupin 2, conserved barrel domain protein
D6B99_05175	COG0671	phosphoesterase, PA-phosphatase related
D6B99_05200	COG5002	protein histidine kinase activity
D6B99_05225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D6B99_05230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D6B99_05240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D6B99_05255	COG0544	peptidyl-prolyl cis-trans isomerase activity
D6B99_05270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D6B99_05275	COG0254	rRNA binding
D6B99_05285	COG1566	PFAM secretion protein HlyD family protein
D6B99_05300	COG0038	chloride channel
D6B99_05305	COG2255	four-way junction helicase activity
D6B99_05310	COG0667	Aldo Keto reductase
D6B99_05315	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D6B99_05315	COG0662	Cupin 2, conserved barrel domain protein
D6B99_05320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D6B99_05330	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D6B99_05335	COG4771	TonB-dependent receptor
D6B99_05340	COG0561	phosphatase activity
D6B99_05350	COG4124	Belongs to the glycosyl hydrolase 26 family
D6B99_05365	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
D6B99_05370	COG2942	2-epimerase
D6B99_05380	COG3345	alpha-galactosidase
D6B99_05385	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_05400	COG2272	Belongs to the type-B carboxylesterase lipase family
D6B99_05410	COG3940	Belongs to the glycosyl hydrolase 43 family
D6B99_05425	COG4771	TonB-dependent receptor
D6B99_05450	COG3250	beta-galactosidase activity
D6B99_05455	COG0450	alkyl hydroperoxide reductase
D6B99_05470	COG1959	2 iron, 2 sulfur cluster binding
D6B99_05475	COG3278	Belongs to the heme-copper respiratory oxidase family
D6B99_05480	COG2010	Cytochrome c
D6B99_05495	COG2346	COG2346, Truncated hemoglobins
D6B99_05505	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D6B99_05510	COG3189	MarR family transcriptional regulator
D6B99_05520	COG0107	imidazoleglycerol-phosphate synthase activity
D6B99_05525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D6B99_05525	COG0140	phosphoribosyl-ATP diphosphatase activity
D6B99_05530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_05535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D6B99_05540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D6B99_05545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D6B99_05550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D6B99_05555	COG0131	Imidazoleglycerol-phosphate dehydratase
D6B99_05555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D6B99_05560	COG0443	Heat shock 70 kDa protein
D6B99_05575	COG4221	oxidoreductase activity
D6B99_05580	COG1127	ABC transporter
D6B99_05585	COG0019	diaminopimelate decarboxylase activity
D6B99_05600	COG3340	Belongs to the peptidase S51 family
D6B99_05610	COG1702	phosphate starvation-inducible protein PhoH
D6B99_05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D6B99_05660	COG1446	asparaginase
D6B99_05665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D6B99_05670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D6B99_05675	COG4974	Belongs to the 'phage' integrase family
D6B99_05700	COG3177	Filamentation induced by cAMP protein fic
D6B99_05710	COG0667	Aldo Keto reductase
D6B99_05720	COG0791	NLP P60 protein
D6B99_05735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D6B99_05740	COG2205	protein histidine kinase activity
D6B99_05745	COG0745	RESPONSE REGULATOR receiver
D6B99_05750	COG3158	transport of potassium into the cell
D6B99_05785	COG0552	protein localization to endoplasmic reticulum
D6B99_05790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D6B99_05800	COG3250	beta-galactosidase activity
D6B99_05805	COG0859	PFAM glycosyl transferase family 9
D6B99_05815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D6B99_05825	COG2989	Protein conserved in bacteria
D6B99_05835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D6B99_05870	COG0564	pseudouridine synthase activity
D6B99_05875	COG1187	pseudouridine synthase activity
D6B99_05880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D6B99_05890	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D6B99_05905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D6B99_05910	COG3655	Transcriptional regulator
D6B99_05945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6B99_05955	COG0489	protein tyrosine kinase activity
D6B99_05965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D6B99_06020	COG0010	Belongs to the arginase family
D6B99_06040	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D6B99_06045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D6B99_06065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D6B99_06070	COG1490	D-aminoacyl-tRNA deacylase activity
D6B99_06075	COG1694	Mazg nucleotide pyrophosphohydrolase
D6B99_06085	COG1199	ATP-dependent helicase activity
D6B99_06085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D6B99_06095	COG0525	valine-tRNA ligase activity
D6B99_06105	COG0545	Peptidyl-prolyl cis-trans isomerase
D6B99_06110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D6B99_06115	COG1501	Belongs to the glycosyl hydrolase 31 family
D6B99_06120	COG3409	Peptidoglycan-binding domain 1 protein
D6B99_06120	COG0793	Belongs to the peptidase S41A family
D6B99_06140	COG1012	belongs to the aldehyde dehydrogenase family
D6B99_06175	COG0058	SHG alpha-glucan phosphorylase activity
D6B99_06180	COG1530	ribonuclease E activity
D6B99_06190	COG0776	regulation of translation
D6B99_06225	COG0612	Peptidase, M16
D6B99_06230	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D6B99_06235	COG1774	PSP1 C-terminal conserved region
D6B99_06240	COG0470	DNA polymerase III
D6B99_06250	COG0386	Belongs to the glutathione peroxidase family
D6B99_06255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D6B99_06255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D6B99_06260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6B99_06275	COG1607	acyl-coa hydrolase
D6B99_06280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D6B99_06285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D6B99_06295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D6B99_06305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D6B99_06310	COG0159	tryptophan synthase activity
D6B99_06320	COG0133	tryptophan synthase activity
D6B99_06330	COG0135	phosphoribosylanthranilate isomerase activity
D6B99_06335	COG0134	indole-3-glycerol-phosphate synthase activity
D6B99_06345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D6B99_06360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D6B99_06365	COG5434	Belongs to the glycosyl hydrolase 28 family
D6B99_06370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D6B99_06375	COG3781	membrane
D6B99_06400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D6B99_06430	COG3590	peptidase
D6B99_06445	COG0492	ferredoxin-NADP+ reductase activity
D6B99_06470	COG1609	Transcriptional regulator
D6B99_06475	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_06485	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D6B99_06500	COG1629	transport
D6B99_06505	COG1501	Belongs to the glycosyl hydrolase 31 family
D6B99_06515	COG2205	protein histidine kinase activity
D6B99_06515	COG0745	RESPONSE REGULATOR receiver
D6B99_06515	COG3292	Two component regulator propeller
D6B99_06520	COG2755	lipolytic protein G-D-S-L family
D6B99_06520	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D6B99_06525	COG3250	beta-galactosidase activity
D6B99_06530	COG1609	Transcriptional regulator
D6B99_06545	COG2755	lipolytic protein G-D-S-L family
D6B99_06570	COG1629	transport
D6B99_06575	COG3292	Two component regulator propeller
D6B99_06575	COG2205	protein histidine kinase activity
D6B99_06575	COG0745	RESPONSE REGULATOR receiver
D6B99_06580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D6B99_06590	COG2755	lipolytic protein G-D-S-L family
D6B99_06590	COG0657	acetylesterase activity
D6B99_06600	COG0657	acetylesterase activity
D6B99_06600	COG2755	lipolytic protein G-D-S-L family
D6B99_06630	COG1309	transcriptional regulator
D6B99_06700	COG0702	epimerase
D6B99_06705	COG4206	TonB-dependent receptor
D6B99_06705	COG1629	transport
D6B99_06745	COG1629	transport
D6B99_06755	COG2814	Major facilitator Superfamily
D6B99_06770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6B99_06775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_06795	COG4771	TonB-dependent receptor
D6B99_06815	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_06820	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_06830	COG1733	regulation of RNA biosynthetic process
D6B99_06840	COG2378	regulation of single-species biofilm formation
D6B99_06845	COG1902	pentaerythritol trinitrate reductase activity
D6B99_06855	COG3384	dioxygenase
D6B99_06860	COG2353	YceI-like domain
D6B99_06865	COG1733	regulation of RNA biosynthetic process
D6B99_06875	COG1733	regulation of RNA biosynthetic process
D6B99_06880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D6B99_06890	COG0583	DNA-binding transcription factor activity
D6B99_06900	COG0488	(ABC) transporter
D6B99_06930	COG4974	Belongs to the 'phage' integrase family
D6B99_06935	COG0517	IMP dehydrogenase activity
D6B99_06950	COG0071	Belongs to the small heat shock protein (HSP20) family
D6B99_06955	COG0587	DNA-directed DNA polymerase activity
D6B99_06985	COG2433	Pfam Transposase IS66
D6B99_07000	COG4974	Belongs to the 'phage' integrase family
D6B99_07040	COG2205	protein histidine kinase activity
D6B99_07040	COG0784	Response regulator, receiver
D6B99_07080	COG4974	Belongs to the 'phage' integrase family
D6B99_07115	COG4771	TonB-dependent receptor
D6B99_07155	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D6B99_07330	COG0612	Peptidase, M16
D6B99_07340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_07345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D6B99_07360	COG1131	(ABC) transporter
D6B99_07365	COG0702	epimerase
D6B99_07370	COG1629	transport
D6B99_07395	COG0702	epimerase
D6B99_07400	COG1629	transport
D6B99_07450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D6B99_07450	COG0574	Belongs to the PEP-utilizing enzyme family
D6B99_07465	COG0574	Belongs to the PEP-utilizing enzyme family
D6B99_07465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D6B99_07470	COG0612	Peptidase, M16
D6B99_07490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D6B99_07495	COG1522	sequence-specific DNA binding
D6B99_07500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_07505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_07510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_07520	COG1629	transport
D6B99_07550	COG4771	TonB-dependent receptor
D6B99_07600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D6B99_07620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D6B99_07645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D6B99_07650	COG3345	alpha-galactosidase
D6B99_07655	COG3250	beta-galactosidase activity
D6B99_07665	COG3537	Alpha-1,2-mannosidase
D6B99_07670	COG3537	Alpha-1,2-mannosidase
D6B99_07710	COG1629	transport
D6B99_07715	COG0702	epimerase
D6B99_07720	COG4771	TonB-dependent receptor
D6B99_07735	COG0702	epimerase
D6B99_07750	COG0738	Major facilitator superfamily
D6B99_07760	COG1501	Belongs to the glycosyl hydrolase 31 family
D6B99_07765	COG3940	Belongs to the glycosyl hydrolase 43 family
D6B99_07780	COG2755	lipolytic protein G-D-S-L family
D6B99_07780	COG0657	acetylesterase activity
D6B99_07790	COG3408	Glycogen debranching enzyme
D6B99_07800	COG3250	beta-galactosidase activity
D6B99_07805	COG0442	prolyl-tRNA aminoacylation
D6B99_07825	COG0284	orotidine-5'-phosphate decarboxylase activity
D6B99_07835	COG2267	carboxylic ester hydrolase activity
D6B99_07845	COG2133	pyrroloquinoline quinone binding
D6B99_07855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D6B99_07865	COG0194	GDP metabolic process
D6B99_07870	COG2234	aminopeptidase activity
D6B99_07920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D6B99_07925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D6B99_07935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D6B99_07940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D6B99_07945	COG0702	epimerase
D6B99_07960	COG2249	NAD(P)H dehydrogenase (quinone) activity
D6B99_08030	COG0531	amino acid
D6B99_08055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D6B99_08060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D6B99_08070	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6B99_08075	COG1546	Belongs to the CinA family
D6B99_08075	COG1058	Belongs to the CinA family
D6B99_08080	COG2814	Major facilitator Superfamily
D6B99_08085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D6B99_08090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D6B99_08115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D6B99_08130	COG1196	nuclear chromosome segregation
D6B99_08135	COG0484	heat shock protein binding
D6B99_08140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D6B99_08150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6B99_08155	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D6B99_08160	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D6B99_08180	COG1132	(ABC) transporter
D6B99_08200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D6B99_08205	COG0488	(ABC) transporter
D6B99_08215	COG3119	arylsulfatase activity
D6B99_08230	COG0702	epimerase
D6B99_08235	COG4771	TonB-dependent receptor
D6B99_08275	COG4628	conserved protein (DUF2132)
D6B99_08285	COG2361	Protein of unknown function DUF86
D6B99_08310	COG1289	transmembrane transporter activity
D6B99_08315	COG0193	aminoacyl-tRNA hydrolase activity
D6B99_08325	COG0629	single-stranded DNA binding
D6B99_08330	COG1216	Glycosyl transferase, family 2
D6B99_08340	COG0628	permease
D6B99_08345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D6B99_08355	COG2045	Belongs to the ComB family
D6B99_08370	COG5002	protein histidine kinase activity
D6B99_08385	COG3237	CsbD-like
D6B99_08405	COG2814	Major facilitator Superfamily
D6B99_08410	COG2160	L-arabinose isomerase activity
D6B99_08420	COG1069	ribulokinase activity
D6B99_08425	COG1595	DNA-templated transcription, initiation
D6B99_08435	COG4771	TonB-dependent receptor
D6B99_08470	COG3347	Dehydrogenase
D6B99_08470	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_08475	COG4952	isomerase
D6B99_08500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D6B99_08505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D6B99_08535	COG3940	Belongs to the glycosyl hydrolase 43 family
D6B99_08540	COG2207	Transcriptional regulator
D6B99_08540	COG0662	Cupin 2, conserved barrel domain protein
D6B99_08545	COG3250	beta-galactosidase activity
D6B99_08555	COG3408	Glycogen debranching enzyme
D6B99_08575	COG3420	alginic acid biosynthetic process
D6B99_08600	COG3408	Glycogen debranching enzyme
D6B99_08605	COG3250	beta-galactosidase activity
D6B99_08630	COG4771	TonB-dependent receptor
D6B99_08655	COG0702	epimerase
D6B99_08660	COG4771	TonB-dependent receptor
D6B99_08670	COG3250	beta-galactosidase activity
D6B99_08690	COG3250	beta-galactosidase activity
D6B99_08700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D6B99_08700	COG1648	precorrin-2 dehydrogenase activity
D6B99_08705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D6B99_08730	COG0243	molybdopterin cofactor binding
D6B99_08735	COG1773	rubredoxin
D6B99_08750	COG0303	'Molybdopterin
D6B99_08775	COG0314	molybdopterin synthase activity
D6B99_08780	COG0521	Mo-molybdopterin cofactor biosynthetic process
D6B99_08780	COG0315	cyclic pyranopterin monophosphate synthase activity
D6B99_08805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D6B99_08830	COG1959	2 iron, 2 sulfur cluster binding
D6B99_08835	COG0604	alcohol dehydrogenase
D6B99_08860	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D6B99_08870	COG0352	thiamine-phosphate diphosphorylase activity
D6B99_08870	COG0351	phosphomethylpyrimidine kinase
D6B99_08870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D6B99_08875	COG0352	thiamine-phosphate diphosphorylase activity
D6B99_08880	COG2022	thiamine diphosphate biosynthetic process
D6B99_08885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D6B99_08895	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
D6B99_08915	COG3537	Alpha-1,2-mannosidase
D6B99_08935	COG0702	epimerase
D6B99_08940	COG4206	TonB-dependent receptor
D6B99_08940	COG1629	transport
D6B99_08970	COG1629	transport
D6B99_08975	COG1609	Transcriptional regulator
D6B99_08980	COG0667	Aldo Keto reductase
D6B99_08985	COG1917	Cupin 2, conserved barrel domain protein
D6B99_08985	COG4977	sequence-specific DNA binding
D6B99_08990	COG0300	oxidoreductase activity
D6B99_08995	COG1501	Belongs to the glycosyl hydrolase 31 family
D6B99_09010	COG2814	Major facilitator Superfamily
D6B99_09025	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D6B99_09030	COG4948	Mandelate Racemase Muconate Lactonizing
D6B99_09045	COG1940	carbohydrate kinase activity
D6B99_09070	COG4771	TonB-dependent receptor
D6B99_09075	COG1609	Transcriptional regulator
D6B99_09080	COG1609	Transcriptional regulator
D6B99_09090	COG3177	Filamentation induced by cAMP protein fic
D6B99_09100	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_09105	COG3321	synthase
D6B99_09105	COG0604	alcohol dehydrogenase
D6B99_09110	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_09115	COG0604	alcohol dehydrogenase
D6B99_09125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D6B99_09135	COG0531	amino acid
D6B99_09140	COG3938	Belongs to the proline racemase family
D6B99_09145	COG1012	belongs to the aldehyde dehydrogenase family
D6B99_09150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D6B99_09165	COG3345	alpha-galactosidase
D6B99_09210	COG0702	epimerase
D6B99_09215	COG4206	TonB-dependent receptor
D6B99_09215	COG1629	transport
D6B99_09235	COG3661	Belongs to the glycosyl hydrolase 67 family
D6B99_09240	COG1501	Belongs to the glycosyl hydrolase 31 family
D6B99_09245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D6B99_09260	COG0702	epimerase
D6B99_09265	COG1629	transport
D6B99_09290	COG2205	protein histidine kinase activity
D6B99_09290	COG0745	RESPONSE REGULATOR receiver
D6B99_09290	COG3292	Two component regulator propeller
D6B99_09295	COG3292	Two component regulator propeller
D6B99_09295	COG0745	RESPONSE REGULATOR receiver
D6B99_09295	COG2205	protein histidine kinase activity
D6B99_09300	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D6B99_09305	COG1629	transport
D6B99_09305	COG4206	TonB-dependent receptor
D6B99_09320	COG3119	arylsulfatase activity
D6B99_09420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D6B99_09470	COG0438	transferase activity, transferring glycosyl groups
D6B99_09480	COG0594	ribonuclease P activity
D6B99_09485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D6B99_09500	COG1809	phosphosulfolactate synthase activity
D6B99_09505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D6B99_09515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D6B99_09520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D6B99_09525	COG0156	8-amino-7-oxononanoate synthase activity
D6B99_09550	COG0148	phosphopyruvate hydratase activity
D6B99_09610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D6B99_09625	COG1064	alcohol dehydrogenase
D6B99_09635	COG0415	Belongs to the DNA photolyase family
D6B99_09660	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D6B99_09675	COG1233	COG1233 Phytoene dehydrogenase and related
D6B99_09695	COG4206	TonB-dependent receptor
D6B99_09700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D6B99_09705	COG0540	Belongs to the ATCase OTCase family
D6B99_09710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D6B99_09730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D6B99_09755	COG0191	fructose-bisphosphate aldolase activity
D6B99_09765	COG0601	transmembrane transport
D6B99_09800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D6B99_09815	COG5002	protein histidine kinase activity
D6B99_09820	COG0745	RESPONSE REGULATOR receiver
D6B99_09835	COG2181	nitrate reductase activity
D6B99_09835	COG0247	lactate metabolic process
D6B99_09840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D6B99_09860	COG0297	glycogen (starch) synthase activity
D6B99_09865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D6B99_09870	COG2721	sulfolactate sulfo-lyase activity
D6B99_09875	COG0246	Mannitol dehydrogenase
D6B99_09880	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D6B99_09900	COG0702	epimerase
D6B99_09905	COG1629	transport
D6B99_09910	COG0702	epimerase
D6B99_09915	COG4771	TonB-dependent receptor
D6B99_09935	COG4677	pectinesterase activity
D6B99_09945	COG4677	pectinesterase activity
D6B99_09950	COG2755	lipolytic protein G-D-S-L family
D6B99_09955	COG2755	lipolytic protein G-D-S-L family
D6B99_09980	COG2211	Major facilitator Superfamily
D6B99_09990	COG0514	ATP-dependent DNA helicase (RecQ)
D6B99_10005	COG4804	nuclease activity
D6B99_10015	COG0138	bifunctional purine biosynthesis protein purh
D6B99_10030	COG0049	tRNA binding
D6B99_10035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D6B99_10040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D6B99_10055	COG3258	Cytochrome c
D6B99_10085	COG0022	dehydrogenase e1 component
D6B99_10085	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6B99_10100	COG1506	peptidase
D6B99_10100	COG0823	Involved in the tonB-independent uptake of proteins
D6B99_10115	COG0528	UMP kinase activity
D6B99_10140	COG0070	glutamate synthase
D6B99_10140	COG0069	glutamate synthase activity
D6B99_10140	COG0067	glutamate synthase
D6B99_10145	COG0473	3-isopropylmalate dehydrogenase activity
D6B99_10160	COG0612	Peptidase, M16
D6B99_10165	COG3335	DDE superfamily endonuclease
D6B99_10185	COG0513	Belongs to the DEAD box helicase family
D6B99_10190	COG1640	4-alpha-glucanotransferase
D6B99_10205	COG0626	cystathionine gamma-synthase activity
D6B99_10240	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D6B99_10270	COG1363	Peptidase, m42
D6B99_10310	COG2226	methyltransferase
D6B99_10335	COG0037	tRNA processing
D6B99_10345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D6B99_10370	COG1054	Belongs to the UPF0176 family
D6B99_10375	COG0038	chloride channel
D6B99_10380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D6B99_10385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D6B99_10390	COG1166	arginine decarboxylase activity
D6B99_10395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D6B99_10425	COG0539	negative regulation of cytoplasmic translation
D6B99_10425	COG2183	response to ionizing radiation
D6B99_10445	COG1629	transport
D6B99_10455	COG3292	Two component regulator propeller
D6B99_10455	COG2205	protein histidine kinase activity
D6B99_10455	COG0745	RESPONSE REGULATOR receiver
D6B99_10460	COG3292	Two component regulator propeller
D6B99_10460	COG2205	protein histidine kinase activity
D6B99_10460	COG0745	RESPONSE REGULATOR receiver
D6B99_10485	COG0662	Cupin 2, conserved barrel domain protein
D6B99_10485	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D6B99_10490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D6B99_10495	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D6B99_10540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D6B99_10545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D6B99_10555	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D6B99_10605	COG3661	Belongs to the glycosyl hydrolase 67 family
D6B99_10615	COG1082	Xylose isomerase domain protein TIM barrel
D6B99_10620	COG3507	Belongs to the glycosyl hydrolase 43 family
D6B99_10625	COG1501	Belongs to the glycosyl hydrolase 31 family
D6B99_10635	COG1501	Belongs to the glycosyl hydrolase 31 family
D6B99_10645	COG5520	Belongs to the glycosyl hydrolase 30 family
D6B99_10660	COG1629	transport
D6B99_10700	COG2382	esterase
D6B99_10700	COG3693	PFAM glycoside hydrolase, family 10
D6B99_10705	COG3693	PFAM glycoside hydrolase, family 10
D6B99_10705	COG2382	esterase
D6B99_10710	COG3693	PFAM glycoside hydrolase, family 10
D6B99_10710	COG3507	Belongs to the glycosyl hydrolase 43 family
D6B99_10710	COG2382	esterase
D6B99_10715	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D6B99_10725	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_10730	COG3507	Belongs to the glycosyl hydrolase 43 family
D6B99_10735	COG3507	Belongs to the glycosyl hydrolase 43 family
D6B99_10755	COG1629	transport
D6B99_10765	COG1629	transport
D6B99_10780	COG2814	Major facilitator Superfamily
D6B99_10780	COG0477	Major facilitator Superfamily
D6B99_10790	COG1070	Carbohydrate kinase
D6B99_10810	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_10840	COG1193	negative regulation of DNA recombination
D6B99_10845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D6B99_10885	COG2226	methyltransferase
D6B99_10890	COG0438	transferase activity, transferring glycosyl groups
D6B99_10895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D6B99_10900	COG1216	Glycosyl transferase, family 2
D6B99_10905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D6B99_10905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D6B99_10915	COG1280	lysine exporter protein (LysE YggA)
D6B99_10930	COG3550	peptidyl-serine autophosphorylation
D6B99_10935	COG3550	peptidyl-serine autophosphorylation
D6B99_10950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D6B99_10955	COG2264	protein methyltransferase activity
D6B99_10975	COG0484	heat shock protein binding
D6B99_10980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D6B99_10985	COG0492	ferredoxin-NADP+ reductase activity
D6B99_10995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D6B99_11020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D6B99_11025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D6B99_11030	COG0307	riboflavin synthase, alpha
D6B99_11040	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_11045	COG1538	Outer membrane efflux protein
D6B99_11055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D6B99_11080	COG4771	TonB-dependent receptor
D6B99_11100	COG1253	flavin adenine dinucleotide binding
D6B99_11110	COG0517	IMP dehydrogenase activity
D6B99_11110	COG0617	tRNA 3'-terminal CCA addition
D6B99_11110	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D6B99_11140	COG2733	membrane
D6B99_11155	COG0702	epimerase
D6B99_11180	COG0640	Transcriptional regulator
D6B99_11205	COG2814	Major facilitator Superfamily
D6B99_11220	COG1309	transcriptional regulator
D6B99_11225	COG3956	TIGRFAM MazG family protein
D6B99_11230	COG5000	phosphorelay sensor kinase activity
D6B99_11235	COG2967	ApaG domain
D6B99_11245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D6B99_11255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D6B99_11275	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D6B99_11290	COG0242	peptide deformylase activity
D6B99_11295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D6B99_11300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D6B99_11305	COG0156	8-amino-7-oxononanoate synthase activity
D6B99_11315	COG0673	inositol 2-dehydrogenase activity
D6B99_11325	COG0018	arginyl-trna synthetase
D6B99_11405	COG3408	Glycogen debranching enzyme
D6B99_11430	COG1172	Belongs to the binding-protein-dependent transport system permease family
D6B99_11435	COG1129	ABC transporter
D6B99_11450	COG3958	Transketolase
D6B99_11455	COG3959	Transketolase, thiamine diphosphate binding domain
D6B99_11465	COG1349	DNA-binding transcription factor activity
D6B99_11475	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_11480	COG0667	Aldo Keto reductase
D6B99_11500	COG1959	2 iron, 2 sulfur cluster binding
D6B99_11505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D6B99_11525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D6B99_11530	COG1192	Involved in chromosome partitioning
D6B99_11535	COG1475	DNA binding
D6B99_11545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D6B99_11550	COG0277	FAD linked oxidase domain protein
D6B99_11565	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D6B99_11620	COG3392	D12 class N6 adenine-specific DNA methyltransferase
D6B99_11725	COG0740	serine-type endopeptidase activity
D6B99_11840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D6B99_11875	COG0640	Transcriptional regulator
D6B99_11895	COG4145	pantothenate transmembrane transporter activity
D6B99_11935	COG3250	beta-galactosidase activity
D6B99_11975	COG0702	epimerase
D6B99_11980	COG4771	TonB-dependent receptor
D6B99_11990	COG1629	transport
D6B99_12000	COG3250	beta-galactosidase activity
D6B99_12005	COG3292	Two component regulator propeller
D6B99_12005	COG3292	Two component regulator propeller
D6B99_12005	COG2205	protein histidine kinase activity
D6B99_12005	COG0745	RESPONSE REGULATOR receiver
D6B99_12005	COG2205	protein histidine kinase activity
D6B99_12005	COG0745	RESPONSE REGULATOR receiver
D6B99_12025	COG3275	phosphorelay sensor kinase activity
D6B99_12030	COG3279	Response regulator of the LytR AlgR family
D6B99_12050	COG4115	mRNA cleavage
D6B99_12065	COG2204	response regulator
D6B99_12080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D6B99_12090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D6B99_12100	COG2205	protein histidine kinase activity
D6B99_12155	COG4771	TonB-dependent receptor
D6B99_12170	COG0702	epimerase
D6B99_12175	COG4771	TonB-dependent receptor
D6B99_12185	COG3250	beta-galactosidase activity
D6B99_12200	COG3250	beta-galactosidase activity
D6B99_12205	COG3401	FG-GAP repeat protein
D6B99_12215	COG2755	lipolytic protein G-D-S-L family
D6B99_12240	COG3119	arylsulfatase activity
D6B99_12245	COG2755	lipolytic protein G-D-S-L family
D6B99_12250	COG0561	phosphatase activity
D6B99_12255	COG4771	TonB-dependent receptor
D6B99_12270	COG4948	Mandelate Racemase Muconate Lactonizing
D6B99_12280	COG4948	Mandelate Racemase Muconate Lactonizing
D6B99_12295	COG3335	DDE superfamily endonuclease
D6B99_12315	COG1629	transport
D6B99_12370	COG2353	YceI-like domain
D6B99_12390	COG1902	pentaerythritol trinitrate reductase activity
D6B99_12400	COG1917	Cupin 2, conserved barrel domain protein
D6B99_12400	COG4977	sequence-specific DNA binding
D6B99_12405	COG0604	alcohol dehydrogenase
D6B99_12405	COG3321	synthase
D6B99_12445	COG0662	Cupin 2, conserved barrel domain protein
D6B99_12445	COG2207	Transcriptional regulator
D6B99_12485	COG2264	protein methyltransferase activity
D6B99_12510	COG2270	Major facilitator Superfamily
D6B99_12515	COG1968	undecaprenyl-diphosphatase activity
D6B99_12520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D6B99_12540	COG1472	Belongs to the glycosyl hydrolase 3 family
D6B99_12545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D6B99_12555	COG3254	rhamnose metabolic process
D6B99_12565	COG3344	reverse transcriptase
D6B99_12575	COG5487	UPF0391 membrane protein
D6B99_12585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D6B99_12585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D6B99_12590	COG0412	Dienelactone hydrolase
D6B99_12600	COG0667	Aldo Keto reductase
D6B99_12605	COG1902	pentaerythritol trinitrate reductase activity
D6B99_12610	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6B99_12615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D6B99_12650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D6B99_12655	COG0702	epimerase
D6B99_12660	COG4771	TonB-dependent receptor
D6B99_12665	COG2186	Transcriptional regulator
D6B99_12670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D6B99_12675	COG1473	amidohydrolase
D6B99_12690	COG3047	cAMP biosynthetic process
D6B99_12690	COG2885	chlorophyll binding
D6B99_12695	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D6B99_12715	COG0482	sulfurtransferase activity
D6B99_12720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D6B99_12730	COG1611	Belongs to the LOG family
D6B99_12735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6B99_12740	COG4152	abc transporter atp-binding protein
D6B99_12755	COG0798	PFAM Bile acid sodium symporter
D6B99_12765	COG2217	Heavy metal translocating P-type atpase
D6B99_12800	COG0505	Belongs to the CarA family
D6B99_12850	COG1518	maintenance of DNA repeat elements
D6B99_12855	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D6B99_12875	COG0667	Aldo Keto reductase
D6B99_12880	COG1064	alcohol dehydrogenase
D6B99_12895	COG1335	isochorismatase
D6B99_12920	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6B99_12930	COG3250	beta-galactosidase activity
D6B99_12950	COG5492	domain, Protein
D6B99_12975	COG1629	transport
D6B99_12980	COG0702	epimerase
D6B99_12985	COG4206	TonB-dependent receptor
D6B99_12985	COG1629	transport
D6B99_12995	COG0745	RESPONSE REGULATOR receiver
D6B99_12995	COG3292	Two component regulator propeller
D6B99_12995	COG2205	protein histidine kinase activity
D6B99_13000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D6B99_13010	COG2721	sulfolactate sulfo-lyase activity
D6B99_13025	COG0179	Fumarylacetoacetate (FAA) hydrolase
D6B99_13030	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_13040	COG3254	rhamnose metabolic process
D6B99_13050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D6B99_13050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D6B99_13075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D6B99_13085	COG0681	Belongs to the peptidase S26 family
D6B99_13095	COG0538	isocitrate dehydrogenase activity
D6B99_13105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D6B99_13135	COG4771	TonB-dependent receptor
D6B99_13150	COG0045	succinate-CoA ligase (ADP-forming) activity
D6B99_13155	COG3537	Alpha-1,2-mannosidase
D6B99_13160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D6B99_13205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D6B99_13210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_13225	COG4654	Cytochrome c, class I
D6B99_13235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D6B99_13250	COG0071	Belongs to the small heat shock protein (HSP20) family
D6B99_13255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6B99_13265	COG0653	protein targeting
D6B99_13270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D6B99_13275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D6B99_13280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D6B99_13310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D6B99_13325	COG1621	beta-fructofuranosidase activity
D6B99_13330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D6B99_13335	COG2151	metal-sulfur cluster biosynthetic enzyme
D6B99_13360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D6B99_13370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D6B99_13395	COG0848	biopolymer transport protein
D6B99_13400	COG0811	peptide transport
D6B99_13430	COG0702	epimerase
D6B99_13435	COG4771	TonB-dependent receptor
D6B99_13450	COG0702	epimerase
D6B99_13455	COG1629	transport
D6B99_13465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D6B99_13470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D6B99_13475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D6B99_13480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D6B99_13485	COG0356	it plays a direct role in the translocation of protons across the membrane
D6B99_13500	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D6B99_13515	COG1253	flavin adenine dinucleotide binding
D6B99_13525	COG2177	Part of the ABC transporter FtsEX involved in
D6B99_13530	COG0495	leucyl-tRNA aminoacylation
D6B99_13545	COG0228	four-way junction DNA binding
D6B99_13550	COG0156	8-amino-7-oxononanoate synthase activity
D6B99_13580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D6B99_13590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D6B99_13600	COG1215	transferase activity, transferring glycosyl groups
D6B99_13610	COG1216	Glycosyl transferase, family 2
D6B99_13615	COG0531	amino acid
D6B99_13625	COG0405	Gamma-glutamyltransferase
D6B99_13635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6B99_13640	COG0450	alkyl hydroperoxide reductase
D6B99_13650	COG0203	ribosomal protein L17
D6B99_13655	COG0202	RNA polymerase activity
D6B99_13660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D6B99_13665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D6B99_13670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D6B99_13675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D6B99_13680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D6B99_13700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6B99_13700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6B99_13720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D6B99_13725	COG0423	glycine-tRNA ligase activity
D6B99_13735	COG1704	LemA family
D6B99_13750	COG0730	response to heat
D6B99_13760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D6B99_13765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D6B99_13765	COG1648	precorrin-2 dehydrogenase activity
D6B99_13775	COG0175	sulfate reduction
D6B99_13780	COG0175	sulfate reduction
D6B99_13790	COG1942	4-Oxalocrotonate Tautomerase
D6B99_13800	COG3279	Response regulator of the LytR AlgR family
D6B99_13805	COG2972	Histidine kinase
D6B99_13810	COG0556	nucleotide-excision repair
D6B99_13815	COG0632	four-way junction helicase activity
D6B99_13845	COG1136	(ABC) transporter
D6B99_13855	COG4948	Mandelate Racemase Muconate Lactonizing
D6B99_13860	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D6B99_13865	COG2086	electron transfer activity
D6B99_13905	COG1131	(ABC) transporter
D6B99_13915	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D6B99_13940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6B99_13945	COG0646	methionine synthase
D6B99_13945	COG1410	methionine synthase
D6B99_13950	COG0646	methionine synthase
D6B99_13950	COG1410	methionine synthase
D6B99_13955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D6B99_13970	COG0210	DNA helicase
D6B99_14010	COG2195	Cleaves the N-terminal amino acid of tripeptides
D6B99_14040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D6B99_14045	COG0105	UTP biosynthetic process
D6B99_14050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D6B99_14060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D6B99_14070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D6B99_14075	COG1104	cysteine desulfurase activity
D6B99_14080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D6B99_14090	COG0463	Glycosyl transferase, family 2
D6B99_14095	COG0436	Aminotransferase
D6B99_14100	COG3457	Alanine racemase
D6B99_14110	COG0416	fatty acid biosynthetic process
D6B99_14125	COG2204	response regulator
D6B99_14130	COG0542	response to heat
D6B99_14145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D6B99_14150	COG1104	cysteine desulfurase activity
D6B99_14165	COG3158	transport of potassium into the cell
D6B99_14175	COG0047	phosphoribosylformylglycinamidine synthase activity
D6B99_14190	COG3119	arylsulfatase activity
D6B99_14195	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6B99_14210	COG1629	transport
D6B99_14215	COG0702	epimerase
D6B99_14230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D6B99_14245	COG3537	Alpha-1,2-mannosidase
D6B99_14285	COG1629	transport
D6B99_14290	COG2205	protein histidine kinase activity
D6B99_14300	COG3537	Alpha-1,2-mannosidase
D6B99_14315	COG4206	TonB-dependent receptor
D6B99_14315	COG1629	transport
D6B99_14355	COG0210	DNA helicase
D6B99_14370	COG1619	proteins homologs of microcin C7 resistance protein MccF
D6B99_14385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D6B99_14400	COG2706	6-phosphogluconolactonase activity
D6B99_14410	COG0069	glutamate synthase activity
D6B99_14420	COG0339	signal peptide processing
D6B99_14440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D6B99_14445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D6B99_14455	COG1629	transport
D6B99_14455	COG4206	TonB-dependent receptor
D6B99_14460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D6B99_14470	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D6B99_14480	COG4585	Histidine kinase
D6B99_14520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D6B99_14525	COG5492	domain, Protein
D6B99_14530	COG1078	dGTPase activity
D6B99_14535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D6B99_14540	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D6B99_14540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D6B99_14565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D6B99_14575	COG1045	serine acetyltransferase
D6B99_14585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D6B99_14585	COG0512	Glutamine amidotransferase of anthranilate synthase
D6B99_14600	COG0514	ATP-dependent DNA helicase (RecQ)
D6B99_14615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D6B99_14620	COG3239	Fatty acid desaturase
D6B99_14625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D6B99_14630	COG0154	amidase activity
D6B99_14715	COG0577	efflux transmembrane transporter activity
D6B99_14720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D6B99_14730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D6B99_14735	COG0602	queuosine metabolic process
D6B99_14740	COG3511	phospholipase C
D6B99_14750	COG1528	Iron-storage protein
D6B99_14755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D6B99_14760	COG0052	Belongs to the universal ribosomal protein uS2 family
D6B99_14765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D6B99_14770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D6B99_14775	COG1678	Uncharacterized ACR, COG1678
D6B99_14780	COG1187	pseudouridine synthase activity
D6B99_14835	COG0702	epimerase
D6B99_14840	COG1629	transport
D6B99_14850	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D6B99_14860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D6B99_14865	COG0460	homoserine dehydrogenase
D6B99_14865	COG0527	aspartate kinase activity
D6B99_14870	COG0083	homoserine kinase activity
D6B99_14880	COG1216	Glycosyl transferase, family 2
D6B99_14880	COG0463	Glycosyl transferase, family 2
D6B99_14885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D6B99_14890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D6B99_14895	COG1981	membrane
D6B99_14940	COG1610	YqeY-like protein
D6B99_14960	COG2885	chlorophyll binding
D6B99_14970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D6B99_14975	COG0460	homoserine dehydrogenase
D6B99_14980	COG0085	RNA polymerase activity
D6B99_15010	COG0811	peptide transport
D6B99_15015	COG3153	acetyltransferase
D6B99_15015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D6B99_15020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D6B99_15025	COG0616	signal peptide processing
D6B99_15045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D6B99_15060	COG1322	Protein conserved in bacteria
D6B99_15090	COG0563	adenylate kinase activity
D6B99_15105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D6B99_15110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D6B99_15150	COG0366	Alpha amylase catalytic
D6B99_15155	COG0366	Alpha amylase catalytic
D6B99_15170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D6B99_15175	COG1629	transport
D6B99_15175	COG4206	TonB-dependent receptor
D6B99_15180	COG1609	Transcriptional regulator
D6B99_15190	COG0300	oxidoreductase activity
D6B99_15195	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D6B99_15205	COG2001	Belongs to the MraZ family
D6B99_15210	COG0275	rRNA processing
D6B99_15220	COG0768	penicillin binding
D6B99_15225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D6B99_15230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D6B99_15235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D6B99_15240	COG0772	Belongs to the SEDS family
D6B99_15245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D6B99_15250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D6B99_15265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D6B99_15275	COG4651	solute:proton antiporter activity
D6B99_15275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D6B99_15300	COG1215	transferase activity, transferring glycosyl groups
D6B99_15310	COG0745	RESPONSE REGULATOR receiver
D6B99_15315	COG2205	protein histidine kinase activity
D6B99_15315	COG3437	response regulator, receiver
D6B99_15315	COG4999	Histidine kinase
D6B99_15315	COG3850	Histidine kinase
D6B99_15320	COG0745	RESPONSE REGULATOR receiver
D6B99_15335	COG5002	protein histidine kinase activity
D6B99_15345	COG2204	response regulator
D6B99_15350	COG2205	protein histidine kinase activity
D6B99_15350	COG4999	Histidine kinase
D6B99_15350	COG3850	Histidine kinase
D6B99_15350	COG3437	response regulator, receiver
D6B99_15375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D6B99_15380	COG0750	zinc metalloprotease
D6B99_15395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D6B99_15410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D6B99_15415	COG0004	ammonium transporteR
D6B99_15420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D6B99_15435	COG5492	domain, Protein
D6B99_15445	COG1136	(ABC) transporter
D6B99_15450	COG2096	Adenosyltransferase
D6B99_15455	COG1136	(ABC) transporter
D6B99_15460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D6B99_15465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D6B99_15520	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_15525	COG1028	Short-chain dehydrogenase reductase Sdr
D6B99_15530	COG4977	sequence-specific DNA binding
D6B99_15555	COG2132	Multicopper oxidase
D6B99_15570	COG4206	TonB-dependent receptor
D6B99_15580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D6B99_15585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D6B99_15600	COG1305	Transglutaminase-like
D6B99_15605	COG0714	Associated with various cellular activities
D6B99_15625	COG0457	Tetratricopeptide repeat
D6B99_15630	COG2081	HI0933 family
D6B99_15645	COG0200	Binds to the 23S rRNA
D6B99_15650	COG1841	ribosomal large subunit assembly
D6B99_15655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D6B99_15660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D6B99_15665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D6B99_15670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D6B99_15675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D6B99_15680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D6B99_15685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D6B99_15690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D6B99_15695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D6B99_15700	COG0255	Belongs to the universal ribosomal protein uL29 family
D6B99_15705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D6B99_15710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D6B99_15720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D6B99_15725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D6B99_15730	COG0089	rRNA binding
D6B99_15735	COG0088	Forms part of the polypeptide exit tunnel
D6B99_15740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D6B99_15745	COG0051	transcription antitermination factor activity, RNA binding
D6B99_15755	COG3250	beta-galactosidase activity
D6B99_15775	COG3459	Glycosyltransferase 36 associated
D6B99_15780	COG0006	proline dipeptidase activity
D6B99_15785	COG1137	ATPase activity
D6B99_15805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D6B99_15830	COG0738	Major facilitator superfamily
D6B99_15835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D6B99_15840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D6B99_15845	COG0195	Participates in both transcription termination and antitermination
D6B99_15850	COG0779	Required for maturation of 30S ribosomal subunits
D6B99_15855	COG3119	arylsulfatase activity
D6B99_15865	COG0017	Asparaginyl-tRNA synthetase
D6B99_15895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D6B99_15905	COG0659	secondary active sulfate transmembrane transporter activity
D6B99_15910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D6B99_15920	COG0497	DNA recombination
D6B99_15930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D6B99_15935	COG1970	mechanosensitive ion channel activity
D6B99_15940	COG2326	polyphosphate kinase activity
D6B99_15950	COG0009	L-threonylcarbamoyladenylate synthase
D6B99_15965	COG1428	Deoxynucleoside kinase
D6B99_15975	COG0726	polysaccharide deacetylase
D6B99_16000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D6B99_16015	COG3876	Protein conserved in bacteria
D6B99_16020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D6B99_16025	COG1607	acyl-coa hydrolase
D6B99_16035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D6B99_16040	COG0081	regulation of translation
D6B99_16045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D6B99_16050	COG0222	ribosome binding
D6B99_16055	COG3142	Participates in the control of copper homeostasis
D6B99_16085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D6B99_16090	COG0463	Glycosyl transferase, family 2
D6B99_16095	COG2176	DNA-directed DNA polymerase activity
D6B99_16100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D6B99_16120	COG0702	epimerase
D6B99_16125	COG4771	TonB-dependent receptor
D6B99_16145	COG1501	Belongs to the glycosyl hydrolase 31 family
D6B99_16155	COG1609	Transcriptional regulator
D6B99_16160	COG1373	ATPase (AAA superfamily
D6B99_16225	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D6B99_16235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6B99_16330	COG0562	UDP-galactopyranose mutase
D6B99_16400	COG4372	Transposase
D6B99_16465	COG1629	transport
D6B99_16465	COG4206	TonB-dependent receptor
D6B99_16555	COG4589	Belongs to the CDS family
D6B99_16560	COG0688	phosphatidylethanolamine metabolic process
D6B99_16565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D6B99_16580	COG1063	alcohol dehydrogenase
D6B99_16585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D6B99_16605	COG0579	oxidoreductase
D6B99_16645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D6B99_16650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D6B99_16655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D6B99_16670	COG1215	transferase activity, transferring glycosyl groups
D6B99_16690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D6B99_16700	COG0592	DNA-directed DNA polymerase activity
D6B99_16710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D6B99_16715	COG0326	Molecular chaperone. Has ATPase activity
D6B99_16735	COG2315	Protein conserved in bacteria
D6B99_16740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D6B99_16745	COG0788	formyltetrahydrofolate deformylase activity
D6B99_16765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D6B99_16770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D6B99_16775	COG0571	ribonuclease III activity
D6B99_16780	COG0726	polysaccharide deacetylase
D6B99_16795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D6B99_16800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D6B99_16805	COG1234	tRNA 3'-trailer cleavage
D6B99_16840	COG0302	gtp cyclohydrolase
D6B99_16845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D6B99_16850	COG0358	DNA primase activity
D6B99_16855	COG2363	Small membrane protein
D6B99_16860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D6B99_16865	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6B99_16870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D6B99_16880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D6B99_16935	COG1022	Amp-dependent synthetase and ligase
D6B99_16945	COG0151	Belongs to the GarS family
D6B99_16975	COG1597	lipid kinase activity
D6B99_16985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D6B99_16995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D6B99_17000	COG0445	tRNA wobble uridine modification
D6B99_17010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D6B99_17015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6B99_17035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D6B99_17065	COG1629	transport
D6B99_17065	COG4206	TonB-dependent receptor
D6B99_17085	COG2884	Cell division ATP-binding protein ftsE
D6B99_17090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D6B99_17095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D6B99_17100	COG0113	porphobilinogen synthase activity
D6B99_17105	COG0408	coproporphyrinogen oxidase activity
D6B99_17120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D6B99_17130	COG0181	hydroxymethylbilane synthase activity
D6B99_17135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D6B99_17140	COG1940	carbohydrate kinase activity
D6B99_17145	COG4771	TonB-dependent receptor
D6B99_17165	COG0343	queuine tRNA-ribosyltransferase activity
D6B99_17175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D6B99_17180	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D6B99_17190	COG2353	YceI-like domain
D6B99_17205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D6B99_17220	COG3011	Protein conserved in bacteria
D6B99_17235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D6B99_17240	COG2361	Protein of unknown function DUF86