locus-tag	class	description
E0W69_000005	COG0772	Belongs to the SEDS family
E0W69_000010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E0W69_000015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0W69_000030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E0W69_000035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E0W69_000040	COG0081	regulation of translation
E0W69_000045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E0W69_000050	COG0222	ribosome binding
E0W69_000055	COG1609	Transcriptional regulator
E0W69_000065	COG1940	carbohydrate kinase activity
E0W69_000075	COG1629	transport
E0W69_000075	COG4206	TonB-dependent receptor
E0W69_000105	COG1629	transport
E0W69_000105	COG4206	TonB-dependent receptor
E0W69_000135	COG3537	Alpha-1,2-mannosidase
E0W69_000150	COG3537	Alpha-1,2-mannosidase
E0W69_000155	COG3537	Alpha-1,2-mannosidase
E0W69_000165	COG1902	pentaerythritol trinitrate reductase activity
E0W69_000170	COG3279	Response regulator of the LytR AlgR family
E0W69_000180	COG0745	RESPONSE REGULATOR receiver
E0W69_000180	COG2972	Histidine kinase
E0W69_000215	COG0308	aminopeptidase N
E0W69_000220	COG5487	UPF0391 membrane protein
E0W69_000235	COG0038	chloride channel
E0W69_000245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E0W69_000270	COG0427	acetyl-CoA hydrolase
E0W69_000280	COG0776	regulation of translation
E0W69_000290	COG1530	ribonuclease E activity
E0W69_000315	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E0W69_000330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E0W69_000335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E0W69_000340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E0W69_000345	COG0612	Peptidase, M16
E0W69_000355	COG0756	dUTP diphosphatase activity
E0W69_000390	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_000400	COG0300	oxidoreductase activity
E0W69_000405	COG1309	transcriptional regulator
E0W69_000415	COG1132	(ABC) transporter
E0W69_000425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E0W69_000430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E0W69_000445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E0W69_000490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0W69_000545	COG0783	Belongs to the Dps family
E0W69_000565	COG1435	thymidine kinase activity
E0W69_000590	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E0W69_000595	COG1408	metallophosphoesterase
E0W69_000600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E0W69_000605	COG1192	Involved in chromosome partitioning
E0W69_000610	COG1475	DNA binding
E0W69_000620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E0W69_000625	COG0277	FAD linked oxidase domain protein
E0W69_000650	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E0W69_000680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E0W69_000705	COG4221	oxidoreductase activity
E0W69_000725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E0W69_000735	COG0740	serine-type endopeptidase activity
E0W69_000745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E0W69_000765	COG0590	tRNA wobble adenosine to inosine editing
E0W69_000775	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
E0W69_000785	COG0612	Peptidase, M16
E0W69_000805	COG0438	transferase activity, transferring glycosyl groups
E0W69_000810	COG0194	GDP metabolic process
E0W69_000830	COG0504	CTP synthase activity
E0W69_000855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0W69_000860	COG2176	DNA-directed DNA polymerase activity
E0W69_000865	COG0463	Glycosyl transferase, family 2
E0W69_000870	COG2211	Major facilitator Superfamily
E0W69_000890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E0W69_000930	COG0069	glutamate synthase activity
E0W69_000930	COG0067	glutamate synthase
E0W69_000930	COG0070	glutamate synthase
E0W69_000945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E0W69_000950	COG1215	transferase activity, transferring glycosyl groups
E0W69_000960	COG5002	protein histidine kinase activity
E0W69_000975	COG4206	TonB-dependent receptor
E0W69_000975	COG1629	transport
E0W69_000995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
E0W69_001005	COG4412	M6 family metalloprotease domain protein
E0W69_001005	COG3291	Pkd domain containing protein
E0W69_001030	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_001055	COG0515	serine threonine protein kinase
E0W69_001055	COG2815	serine threonine protein kinase
E0W69_001060	COG1181	Belongs to the D-alanine--D-alanine ligase family
E0W69_001065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0W69_001090	COG4206	TonB-dependent receptor
E0W69_001090	COG1629	transport
E0W69_001110	COG1228	amidohydrolase
E0W69_001120	COG0823	Involved in the tonB-independent uptake of proteins
E0W69_001120	COG1506	peptidase
E0W69_001125	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E0W69_001125	COG3264	Mechanosensitive ion channel
E0W69_001130	COG0217	transcriptional regulatory protein
E0W69_001135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E0W69_001145	COG0523	cobalamin synthesis protein
E0W69_001150	COG1301	dicarboxylic acid transport
E0W69_001155	COG0456	acetyltransferase
E0W69_001155	COG1846	Transcriptional regulator
E0W69_001160	COG1846	Transcriptional regulator
E0W69_001160	COG0456	acetyltransferase
E0W69_001175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_001180	COG4232	protein-disulfide reductase activity
E0W69_001195	COG3158	transport of potassium into the cell
E0W69_001215	COG0583	DNA-binding transcription factor activity
E0W69_001220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E0W69_001225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E0W69_001245	COG2003	Belongs to the UPF0758 family
E0W69_001290	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
E0W69_001405	COG4206	TonB-dependent receptor
E0W69_001405	COG1629	transport
E0W69_001455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E0W69_001460	COG2224	Isocitrate lyase
E0W69_001465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E0W69_001475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E0W69_001495	COG0443	Heat shock 70 kDa protein
E0W69_001510	COG0667	Aldo Keto reductase
E0W69_001530	COG0360	Binds together with S18 to 16S ribosomal RNA
E0W69_001535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E0W69_001540	COG0359	binds to the 23S rRNA
E0W69_001555	COG0366	Alpha amylase catalytic
E0W69_001580	COG2602	Beta-lactamase
E0W69_001580	COG4219	Peptidase M56
E0W69_001590	COG0673	inositol 2-dehydrogenase activity
E0W69_001640	COG2312	Erythromycin esterase
E0W69_001645	COG2855	membrane
E0W69_001650	COG0583	DNA-binding transcription factor activity
E0W69_001670	COG3655	Transcriptional regulator
E0W69_001695	COG0745	RESPONSE REGULATOR receiver
E0W69_001700	COG1368	sulfuric ester hydrolase activity
E0W69_001715	COG4619	ABC transporter
E0W69_001720	COG0390	transport system, permease component
E0W69_001730	COG0488	(ABC) transporter
E0W69_001735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E0W69_001745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E0W69_001750	COG3958	Transketolase
E0W69_001770	COG0107	imidazoleglycerol-phosphate synthase activity
E0W69_001775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E0W69_001775	COG0140	phosphoribosyl-ATP diphosphatase activity
E0W69_001780	COG1064	alcohol dehydrogenase
E0W69_001805	COG1381	Involved in DNA repair and RecF pathway recombination
E0W69_001810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0W69_001825	COG2181	nitrate reductase activity
E0W69_001825	COG0247	lactate metabolic process
E0W69_001830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E0W69_001830	COG0517	IMP dehydrogenase activity
E0W69_001865	COG0456	acetyltransferase
E0W69_001875	COG0557	exoribonuclease II activity
E0W69_001880	COG1663	tetraacyldisaccharide 4'-kinase activity
E0W69_001885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E0W69_001900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E0W69_001910	COG1393	Belongs to the ArsC family
E0W69_001920	COG0626	cystathionine gamma-synthase activity
E0W69_001925	COG0367	asparagine synthase
E0W69_001955	COG1253	flavin adenine dinucleotide binding
E0W69_001960	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E0W69_001990	COG0492	ferredoxin-NADP+ reductase activity
E0W69_001995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E0W69_002000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E0W69_002015	COG1570	exodeoxyribonuclease VII activity
E0W69_002025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E0W69_002065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E0W69_002090	COG1546	Belongs to the CinA family
E0W69_002090	COG1058	Belongs to the CinA family
E0W69_002095	COG2027	D-alanyl-D-alanine carboxypeptidase
E0W69_002115	COG2207	Transcriptional regulator
E0W69_002135	COG1733	regulation of RNA biosynthetic process
E0W69_002140	COG0596	Alpha beta hydrolase
E0W69_002155	COG0531	amino acid
E0W69_002160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E0W69_002160	COG1519	Transferase
E0W69_002165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E0W69_002170	COG2204	response regulator
E0W69_002200	COG0629	single-stranded DNA binding
E0W69_002210	COG0482	sulfurtransferase activity
E0W69_002220	COG0708	Exodeoxyribonuclease III
E0W69_002230	COG0776	regulation of translation
E0W69_002260	COG0009	L-threonylcarbamoyladenylate synthase
E0W69_002265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E0W69_002285	COG0460	homoserine dehydrogenase
E0W69_002285	COG0527	aspartate kinase activity
E0W69_002290	COG0083	homoserine kinase activity
E0W69_002295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E0W69_002300	COG4555	ABC transporter
E0W69_002330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E0W69_002340	COG0436	Aminotransferase
E0W69_002355	COG0531	amino acid
E0W69_002360	COG0012	GTP binding
E0W69_002365	COG1368	sulfuric ester hydrolase activity
E0W69_002370	COG0492	ferredoxin-NADP+ reductase activity
E0W69_002390	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E0W69_002415	COG0481	GTPase activity
E0W69_002420	COG2755	lipolytic protein G-D-S-L family
E0W69_002420	COG0657	acetylesterase activity
E0W69_002445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0W69_002455	COG0228	four-way junction DNA binding
E0W69_002460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E0W69_002470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E0W69_002485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0W69_002490	COG0825	malonyl-CoA metabolic process
E0W69_002500	COG2003	Belongs to the UPF0758 family
E0W69_002535	COG4206	TonB-dependent receptor
E0W69_002535	COG1629	transport
E0W69_002600	COG2003	Belongs to the UPF0758 family
E0W69_002615	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E0W69_002620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E0W69_002650	COG3275	phosphorelay sensor kinase activity
E0W69_002655	COG3279	Response regulator of the LytR AlgR family
E0W69_002690	COG4206	TonB-dependent receptor
E0W69_002690	COG1629	transport
E0W69_002745	COG2274	protein secretion by the type I secretion system
E0W69_002795	COG4771	TonB-dependent receptor
E0W69_002820	COG1309	transcriptional regulator
E0W69_002825	COG2322	membrane
E0W69_002870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0W69_002885	COG0288	reversible hydration of carbon dioxide
E0W69_002890	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_002925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E0W69_002935	COG0335	large ribosomal subunit rRNA binding
E0W69_002940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E0W69_002945	COG0154	amidase activity
E0W69_002955	COG0514	ATP-dependent DNA helicase (RecQ)
E0W69_002960	COG1131	(ABC) transporter
E0W69_002975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E0W69_003000	COG1104	cysteine desulfurase activity
E0W69_003010	COG1770	oligopeptidase
E0W69_003020	COG0564	pseudouridine synthase activity
E0W69_003025	COG1187	pseudouridine synthase activity
E0W69_003030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E0W69_003035	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_003050	COG1702	phosphate starvation-inducible protein PhoH
E0W69_003080	COG1629	transport
E0W69_003080	COG4206	TonB-dependent receptor
E0W69_003085	COG0561	phosphatase activity
E0W69_003090	COG5520	Belongs to the glycosyl hydrolase 30 family
E0W69_003100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E0W69_003115	COG0544	peptidyl-prolyl cis-trans isomerase activity
E0W69_003135	COG2177	Part of the ABC transporter FtsEX involved in
E0W69_003140	COG0495	leucyl-tRNA aminoacylation
E0W69_003160	COG0739	heme binding
E0W69_003175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_003185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E0W69_003200	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
E0W69_003220	COG1609	Transcriptional regulator
E0W69_003235	COG0402	S-adenosylhomocysteine deaminase activity
E0W69_003250	COG0596	Alpha beta hydrolase
E0W69_003260	COG0628	permease
E0W69_003265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E0W69_003280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E0W69_003285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E0W69_003295	COG0156	8-amino-7-oxononanoate synthase activity
E0W69_003305	COG4948	Mandelate Racemase Muconate Lactonizing
E0W69_003320	COG0527	aspartate kinase activity
E0W69_003340	COG0187	DNA topoisomerase II activity
E0W69_003350	COG0531	amino acid
E0W69_003355	COG4303	Ethanolamine ammonia lyase large subunit
E0W69_003360	COG4302	ethanolamine ammonia-lyase activity
E0W69_003370	COG3511	phospholipase C
E0W69_003410	COG0617	tRNA 3'-terminal CCA addition
E0W69_003420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E0W69_003425	COG2186	Transcriptional regulator
E0W69_003445	COG0148	phosphopyruvate hydratase activity
E0W69_003470	COG3275	phosphorelay sensor kinase activity
E0W69_003500	COG1694	Mazg nucleotide pyrophosphohydrolase
E0W69_003505	COG1490	D-aminoacyl-tRNA deacylase activity
E0W69_003510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E0W69_003520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E0W69_003525	COG0668	transmembrane transport
E0W69_003535	COG1695	Transcriptional regulator
E0W69_003545	COG3279	Response regulator of the LytR AlgR family
E0W69_003575	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E0W69_003575	COG3264	Mechanosensitive ion channel
E0W69_003580	COG2226	methyltransferase
E0W69_003585	COG0714	Associated with various cellular activities
E0W69_003605	COG1196	nuclear chromosome segregation
E0W69_003615	COG4771	TonB-dependent receptor
E0W69_003650	COG4297	protein containing double-stranded beta helix domain
E0W69_003655	COG1666	GTP binding
E0W69_003675	COG0424	maF-like protein
E0W69_003700	COG4948	Mandelate Racemase Muconate Lactonizing
E0W69_003710	COG1085	galactose-1-phosphate uridylyltransferase
E0W69_003715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E0W69_003730	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E0W69_003735	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_003760	COG2135	peptidase activity
E0W69_003765	COG0058	SHG alpha-glucan phosphorylase activity
E0W69_003775	COG1914	H( )-stimulated, divalent metal cation uptake system
E0W69_003785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E0W69_003790	COG1349	DNA-binding transcription factor activity
E0W69_003795	COG1629	transport
E0W69_003795	COG4206	TonB-dependent receptor
E0W69_003810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E0W69_003815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E0W69_003820	COG1166	arginine decarboxylase activity
E0W69_003825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0W69_003830	COG0037	tRNA processing
E0W69_003835	COG0724	RNA recognition motif
E0W69_003840	COG1278	Cold shock
E0W69_003850	COG0706	membrane insertase activity
E0W69_003875	COG1803	Methylglyoxal synthase
E0W69_003885	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E0W69_003895	COG1640	4-alpha-glucanotransferase
E0W69_003910	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_003915	COG1733	regulation of RNA biosynthetic process
E0W69_003920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_003925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_003935	COG1629	transport
E0W69_003935	COG4206	TonB-dependent receptor
E0W69_003945	COG1342	Belongs to the UPF0251 family
E0W69_003950	COG0612	Peptidase, M16
E0W69_003965	COG1917	Cupin 2, conserved barrel domain protein
E0W69_003965	COG4977	sequence-specific DNA binding
E0W69_003970	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_003990	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_003995	COG1484	DNA-dependent DNA replication
E0W69_004000	COG2390	Transcriptional regulator
E0W69_004000	COG4584	PFAM Integrase catalytic
E0W69_004015	COG2247	cell wall binding repeat
E0W69_004015	COG0860	N-Acetylmuramoyl-L-alanine amidase
E0W69_004020	COG0738	Major facilitator superfamily
E0W69_004025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E0W69_004030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E0W69_004040	COG1917	Cupin 2, conserved barrel domain protein
E0W69_004040	COG2207	Transcriptional regulator
E0W69_004045	COG4716	Myosin-crossreactive antigen
E0W69_004055	COG0667	Aldo Keto reductase
E0W69_004100	COG4106	trans-aconitate 2-methyltransferase activity
E0W69_004105	COG1764	response to oxidative stress
E0W69_004115	COG0778	Nitroreductase
E0W69_004120	COG1846	Transcriptional regulator
E0W69_004145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E0W69_004165	COG0488	(ABC) transporter
E0W69_004170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E0W69_004185	COG4145	pantothenate transmembrane transporter activity
E0W69_004205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E0W69_004210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E0W69_004215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E0W69_004245	COG0018	arginyl-trna synthetase
E0W69_004250	COG1428	Deoxynucleoside kinase
E0W69_004255	COG0180	Tryptophanyl-tRNA synthetase
E0W69_004270	COG0442	prolyl-tRNA aminoacylation
E0W69_004285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E0W69_004290	COG0297	glycogen (starch) synthase activity
E0W69_004295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E0W69_004320	COG2195	Cleaves the N-terminal amino acid of tripeptides
E0W69_004325	COG1012	belongs to the aldehyde dehydrogenase family
E0W69_004355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E0W69_004360	COG1902	pentaerythritol trinitrate reductase activity
E0W69_004370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E0W69_004390	COG1335	isochorismatase
E0W69_004405	COG1733	regulation of RNA biosynthetic process
E0W69_004420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E0W69_004430	COG1780	Probably involved in ribonucleotide reductase function
E0W69_004435	COG0552	protein localization to endoplasmic reticulum
E0W69_004440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E0W69_004445	COG1051	belongs to the nudix hydrolase family
E0W69_004450	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E0W69_004455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E0W69_004465	COG0167	dihydroorotate dehydrogenase activity
E0W69_004470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0W69_004480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0W69_004505	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_004510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E0W69_004530	COG2239	Acts as a magnesium transporter
E0W69_004535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E0W69_004545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E0W69_004550	COG0131	Imidazoleglycerol-phosphate dehydratase
E0W69_004560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E0W69_004570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E0W69_004570	COG0512	Glutamine amidotransferase of anthranilate synthase
E0W69_004575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E0W69_004585	COG0134	indole-3-glycerol-phosphate synthase activity
E0W69_004605	COG0133	tryptophan synthase activity
E0W69_004610	COG0159	tryptophan synthase activity
E0W69_004615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E0W69_004620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E0W69_004625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0W69_004630	COG1301	dicarboxylic acid transport
E0W69_004635	COG0586	Pfam SNARE associated Golgi protein
E0W69_004640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E0W69_004650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0W69_004695	COG0438	transferase activity, transferring glycosyl groups
E0W69_004700	COG0110	maltose O-acetyltransferase activity
E0W69_004705	COG0463	Glycosyl transferase, family 2
E0W69_004710	COG0463	Glycosyl transferase, family 2
E0W69_004710	COG1216	Glycosyl transferase, family 2
E0W69_004720	COG0297	glycogen (starch) synthase activity
E0W69_004735	COG0739	heme binding
E0W69_004740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0W69_004755	COG0431	NADPH-dependent FMN reductase
E0W69_004760	COG0316	Belongs to the HesB IscA family
E0W69_004765	COG0719	Fe-S assembly protein
E0W69_004770	COG0396	ATPase activity
E0W69_004775	COG0719	Fe-S assembly protein
E0W69_004780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E0W69_004785	COG2166	iron-sulfur cluster assembly
E0W69_004790	COG2151	metal-sulfur cluster biosynthetic enzyme
E0W69_004810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E0W69_004815	COG0297	glycogen (starch) synthase activity
E0W69_004820	COG1940	carbohydrate kinase activity
E0W69_004825	COG0420	3'-5' exonuclease activity
E0W69_004830	COG0419	ATPase involved in DNA repair
E0W69_004835	COG0514	ATP-dependent DNA helicase (RecQ)
E0W69_004845	COG1950	PFAM Membrane protein of
E0W69_004855	COG0612	Peptidase, M16
E0W69_004875	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E0W69_004880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E0W69_004900	COG0025	NhaP-type Na H and K H
E0W69_004940	COG2003	Belongs to the UPF0758 family
E0W69_004980	COG1247	-acetyltransferase
E0W69_004990	COG0798	PFAM Bile acid sodium symporter
E0W69_005005	COG4974	Belongs to the 'phage' integrase family
E0W69_005055	COG2003	Belongs to the UPF0758 family
E0W69_005090	COG2274	protein secretion by the type I secretion system
E0W69_005160	COG1629	transport
E0W69_005160	COG4206	TonB-dependent receptor
E0W69_005170	COG2003	Belongs to the UPF0758 family
E0W69_005225	COG1136	(ABC) transporter
E0W69_005225	COG0577	efflux transmembrane transporter activity
E0W69_005230	COG1136	(ABC) transporter
E0W69_005240	COG3275	phosphorelay sensor kinase activity
E0W69_005245	COG3279	Response regulator of the LytR AlgR family
E0W69_005280	COG3275	phosphorelay sensor kinase activity
E0W69_005285	COG3279	Response regulator of the LytR AlgR family
E0W69_005295	COG2801	Transposase and inactivated derivatives
E0W69_005310	COG2801	Transposase and inactivated derivatives
E0W69_005340	COG4206	TonB-dependent receptor
E0W69_005340	COG1629	transport
E0W69_005360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0W69_005365	COG1793	dna ligase
E0W69_005365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E0W69_005370	COG1793	dna ligase
E0W69_005400	COG2755	lipolytic protein G-D-S-L family
E0W69_005405	COG3119	arylsulfatase activity
E0W69_005415	COG4206	TonB-dependent receptor
E0W69_005415	COG1629	transport
E0W69_005420	COG3119	arylsulfatase activity
E0W69_005430	COG0583	DNA-binding transcription factor activity
E0W69_005440	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E0W69_005470	COG0659	secondary active sulfate transmembrane transporter activity
E0W69_005490	COG2207	Transcriptional regulator
E0W69_005490	COG1917	Cupin 2, conserved barrel domain protein
E0W69_005495	COG2197	response regulator
E0W69_005520	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E0W69_005525	COG0352	thiamine-phosphate diphosphorylase activity
E0W69_005530	COG0352	thiamine-phosphate diphosphorylase activity
E0W69_005530	COG0351	phosphomethylpyrimidine kinase
E0W69_005540	COG2194	sulfuric ester hydrolase activity
E0W69_005545	COG0671	phosphoesterase, PA-phosphatase related
E0W69_005555	COG2814	Major facilitator Superfamily
E0W69_005565	COG0277	FAD linked oxidase domain protein
E0W69_005570	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_005575	COG1917	Cupin 2, conserved barrel domain protein
E0W69_005575	COG4977	sequence-specific DNA binding
E0W69_005590	COG3279	Response regulator of the LytR AlgR family
E0W69_005595	COG3275	phosphorelay sensor kinase activity
E0W69_005605	COG2197	response regulator
E0W69_005610	COG0110	maltose O-acetyltransferase activity
E0W69_005630	COG0671	phosphoesterase, PA-phosphatase related
E0W69_005655	COG5002	protein histidine kinase activity
E0W69_005665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0W69_005670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E0W69_005675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E0W69_005700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E0W69_005705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E0W69_005715	COG0489	protein tyrosine kinase activity
E0W69_005720	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E0W69_005725	COG0191	fructose-bisphosphate aldolase activity
E0W69_005745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E0W69_005750	COG3279	Response regulator of the LytR AlgR family
E0W69_005755	COG3275	phosphorelay sensor kinase activity
E0W69_005765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E0W69_005770	COG1674	ftsk spoiiie
E0W69_005775	COG1607	acyl-coa hydrolase
E0W69_005785	COG2249	NAD(P)H dehydrogenase (quinone) activity
E0W69_005800	COG0443	Heat shock 70 kDa protein
E0W69_005805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_005810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E0W69_005860	COG1017	nitric oxide dioxygenase activity
E0W69_005860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0W69_005870	COG3250	beta-galactosidase activity
E0W69_005890	COG0284	orotidine-5'-phosphate decarboxylase activity
E0W69_005905	COG2723	6-phospho-beta-galactosidase activity
E0W69_005920	COG1446	asparaginase
E0W69_005935	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E0W69_005975	COG2814	Major facilitator Superfamily
E0W69_005985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E0W69_005995	COG4977	sequence-specific DNA binding
E0W69_006070	COG0745	RESPONSE REGULATOR receiver
E0W69_006090	COG0326	Molecular chaperone. Has ATPase activity
E0W69_006115	COG0436	Aminotransferase
E0W69_006120	COG0463	Glycosyl transferase, family 2
E0W69_006130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E0W69_006140	COG4974	Belongs to the 'phage' integrase family
E0W69_006190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_006200	COG4804	nuclease activity
E0W69_006210	COG0517	IMP dehydrogenase activity
E0W69_006215	COG0596	Alpha beta hydrolase
E0W69_006245	COG3279	Response regulator of the LytR AlgR family
E0W69_006255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0W69_006275	COG3401	FG-GAP repeat protein
E0W69_006300	COG1629	transport
E0W69_006300	COG4206	TonB-dependent receptor
E0W69_006325	COG4206	TonB-dependent receptor
E0W69_006325	COG1629	transport
E0W69_006335	COG1506	peptidase
E0W69_006335	COG4946	Tricorn protease homolog
E0W69_006335	COG0823	Involved in the tonB-independent uptake of proteins
E0W69_006340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_006395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E0W69_006405	COG1595	DNA-templated transcription, initiation
E0W69_006445	COG2390	Transcriptional regulator
E0W69_006445	COG4584	PFAM Integrase catalytic
E0W69_006450	COG1484	DNA-dependent DNA replication
E0W69_006470	COG1764	response to oxidative stress
E0W69_006480	COG3040	lipid binding
E0W69_006490	COG1733	regulation of RNA biosynthetic process
E0W69_006515	COG2267	carboxylic ester hydrolase activity
E0W69_006520	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_006530	COG0300	oxidoreductase activity
E0W69_006540	COG0154	amidase activity
E0W69_006560	COG0640	Transcriptional regulator
E0W69_006610	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_006615	COG4977	sequence-specific DNA binding
E0W69_006615	COG1917	Cupin 2, conserved barrel domain protein
E0W69_006620	COG4221	oxidoreductase activity
E0W69_006625	COG1733	regulation of RNA biosynthetic process
E0W69_006640	COG0667	Aldo Keto reductase
E0W69_006645	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_006685	COG1073	alpha beta
E0W69_006690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_006715	COG5002	protein histidine kinase activity
E0W69_006720	COG2205	protein histidine kinase activity
E0W69_006730	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E0W69_006745	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E0W69_006760	COG2204	response regulator
E0W69_006770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0W69_006780	COG2011	ABC-type metal ion transport system permease component
E0W69_006790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E0W69_006795	COG0523	cobalamin synthesis protein
E0W69_006825	COG2733	membrane
E0W69_006830	COG1741	Belongs to the pirin family
E0W69_006845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E0W69_006850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E0W69_006860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E0W69_006880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E0W69_006885	COG0303	'Molybdopterin
E0W69_006890	COG0315	cyclic pyranopterin monophosphate synthase activity
E0W69_006895	COG0746	molybdenum cofactor guanylyltransferase activity
E0W69_006915	COG2207	Transcriptional regulator
E0W69_006950	COG3537	Alpha-1,2-mannosidase
E0W69_006955	COG0702	epimerase
E0W69_006965	COG0667	Aldo Keto reductase
E0W69_006970	COG1064	alcohol dehydrogenase
E0W69_006990	COG0656	L-ascorbic acid biosynthetic process
E0W69_006995	COG1064	alcohol dehydrogenase
E0W69_007000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0W69_007040	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_007055	COG0604	alcohol dehydrogenase
E0W69_007065	COG0300	oxidoreductase activity
E0W69_007085	COG0477	Major facilitator Superfamily
E0W69_007100	COG2814	Major facilitator Superfamily
E0W69_007105	COG2140	Oxalate decarboxylase
E0W69_007130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0W69_007135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0W69_007165	COG3275	phosphorelay sensor kinase activity
E0W69_007170	COG3279	Response regulator of the LytR AlgR family
E0W69_007185	COG4221	oxidoreductase activity
E0W69_007190	COG2814	Major facilitator Superfamily
E0W69_007205	COG0488	(ABC) transporter
E0W69_007215	COG0157	Belongs to the NadC ModD family
E0W69_007220	COG0023	Translation Initiation Factor
E0W69_007235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E0W69_007240	COG0105	UTP biosynthetic process
E0W69_007245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E0W69_007250	COG0545	Peptidyl-prolyl cis-trans isomerase
E0W69_007255	COG0459	protein refolding
E0W69_007260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E0W69_007270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0W69_007275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_007280	COG1199	ATP-dependent helicase activity
E0W69_007280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0W69_007290	COG0525	valine-tRNA ligase activity
E0W69_007300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0W69_007305	COG1950	PFAM Membrane protein of
E0W69_007310	COG0527	aspartate kinase activity
E0W69_007320	COG1131	(ABC) transporter
E0W69_007345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E0W69_007350	COG3961	Belongs to the TPP enzyme family
E0W69_007370	COG4974	Belongs to the 'phage' integrase family
E0W69_007385	COG3385	transposase activity
E0W69_007415	COG1309	transcriptional regulator
E0W69_007425	COG1733	regulation of RNA biosynthetic process
E0W69_007430	COG2814	Major facilitator Superfamily
E0W69_007445	COG1538	Outer membrane efflux protein
E0W69_007450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0W69_007455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0W69_007465	COG0667	Aldo Keto reductase
E0W69_007470	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_007475	COG2003	Belongs to the UPF0758 family
E0W69_007480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E0W69_007490	COG1204	response to ionizing radiation
E0W69_007505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E0W69_007560	COG1595	DNA-templated transcription, initiation
E0W69_007570	COG4206	TonB-dependent receptor
E0W69_007570	COG1629	transport
E0W69_007740	COG2801	Transposase and inactivated derivatives
E0W69_007770	COG0667	Aldo Keto reductase
E0W69_007800	COG0604	alcohol dehydrogenase
E0W69_007815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_007830	COG4206	TonB-dependent receptor
E0W69_007830	COG1629	transport
E0W69_007870	COG1629	transport
E0W69_007870	COG4206	TonB-dependent receptor
E0W69_007875	COG5002	protein histidine kinase activity
E0W69_007880	COG3437	response regulator, receiver
E0W69_007890	COG3275	phosphorelay sensor kinase activity
E0W69_007895	COG3279	Response regulator of the LytR AlgR family
E0W69_007905	COG3279	Response regulator of the LytR AlgR family
E0W69_007915	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E0W69_007920	COG2801	Transposase and inactivated derivatives
E0W69_007935	COG1904	glucuronate isomerase
E0W69_007950	COG1063	alcohol dehydrogenase
E0W69_007965	COG3250	beta-galactosidase activity
E0W69_007985	COG0673	inositol 2-dehydrogenase activity
E0W69_008000	COG3458	cephalosporin-C deacetylase activity
E0W69_008010	COG3250	beta-galactosidase activity
E0W69_008060	COG4206	TonB-dependent receptor
E0W69_008060	COG1629	transport
E0W69_008070	COG3250	beta-galactosidase activity
E0W69_008100	COG1070	Carbohydrate kinase
E0W69_008105	COG4952	isomerase
E0W69_008110	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_008110	COG3347	Dehydrogenase
E0W69_008135	COG0693	protein deglycase activity
E0W69_008140	COG0656	L-ascorbic acid biosynthetic process
E0W69_008145	COG0300	oxidoreductase activity
E0W69_008175	COG0305	Participates in initiation and elongation during chromosome replication
E0W69_008190	COG1012	belongs to the aldehyde dehydrogenase family
E0W69_008200	COG3384	dioxygenase
E0W69_008220	COG0606	chelatase, subunit chli
E0W69_008245	COG3507	Belongs to the glycosyl hydrolase 43 family
E0W69_008265	COG1082	Xylose isomerase domain protein TIM barrel
E0W69_008280	COG4206	TonB-dependent receptor
E0W69_008280	COG1629	transport
E0W69_008295	COG2160	L-arabinose isomerase activity
E0W69_008315	COG3477	response to acidic pH
E0W69_008340	COG0386	Belongs to the glutathione peroxidase family
E0W69_008345	COG1271	oxidase subunit
E0W69_008375	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_008405	COG1629	transport
E0W69_008405	COG4206	TonB-dependent receptor
E0W69_008460	COG1216	Glycosyl transferase, family 2
E0W69_008515	COG2003	Belongs to the UPF0758 family
E0W69_008575	COG4974	Belongs to the 'phage' integrase family
E0W69_008605	COG0583	DNA-binding transcription factor activity
E0W69_008615	COG2030	dehydratase
E0W69_008620	COG0427	acetyl-CoA hydrolase
E0W69_008635	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_008640	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_008650	COG0546	phosphoglycolate phosphatase activity
E0W69_008655	COG1484	DNA-dependent DNA replication
E0W69_008660	COG4584	PFAM Integrase catalytic
E0W69_008660	COG2390	Transcriptional regulator
E0W69_008685	COG2003	Belongs to the UPF0758 family
E0W69_008740	COG2274	protein secretion by the type I secretion system
E0W69_008750	COG4584	PFAM Integrase catalytic
E0W69_008750	COG2390	Transcriptional regulator
E0W69_008755	COG1484	DNA-dependent DNA replication
E0W69_008790	COG4804	nuclease activity
E0W69_008815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_008830	COG1629	transport
E0W69_008830	COG4206	TonB-dependent receptor
E0W69_008860	COG2003	Belongs to the UPF0758 family
E0W69_008915	COG4974	Belongs to the 'phage' integrase family
E0W69_008965	COG2003	Belongs to the UPF0758 family
E0W69_009005	COG2274	protein secretion by the type I secretion system
E0W69_009060	COG1794	racemase activity, acting on amino acids and derivatives
E0W69_009075	COG2755	lipolytic protein G-D-S-L family
E0W69_009080	COG3401	FG-GAP repeat protein
E0W69_009090	COG2755	lipolytic protein G-D-S-L family
E0W69_009130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
E0W69_009135	COG0246	Mannitol dehydrogenase
E0W69_009140	COG2721	sulfolactate sulfo-lyase activity
E0W69_009145	COG1904	glucuronate isomerase
E0W69_009160	COG2271	Major facilitator Superfamily
E0W69_009165	COG1312	Catalyzes the dehydration of D-mannonate
E0W69_009265	COG1061	Type III restriction enzyme res subunit
E0W69_009280	COG0305	Participates in initiation and elongation during chromosome replication
E0W69_009555	COG2003	Belongs to the UPF0758 family
E0W69_009560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E0W69_009570	COG1431	PFAM Stem cell self-renewal protein Piwi
E0W69_009580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E0W69_009630	COG1595	DNA-templated transcription, initiation
E0W69_009640	COG1629	transport
E0W69_009640	COG4206	TonB-dependent receptor
E0W69_009655	COG4977	sequence-specific DNA binding
E0W69_009655	COG1917	Cupin 2, conserved barrel domain protein
E0W69_009785	COG1917	Cupin 2, conserved barrel domain protein
E0W69_009785	COG4977	sequence-specific DNA binding
E0W69_009795	COG1917	Cupin 2, conserved barrel domain protein
E0W69_009795	COG4977	sequence-specific DNA binding
E0W69_009800	COG4221	oxidoreductase activity
E0W69_009850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0W69_009860	COG1538	Outer membrane efflux protein
E0W69_009880	COG1733	regulation of RNA biosynthetic process
E0W69_009905	COG3708	Transcriptional regulator
E0W69_009905	COG2207	Transcriptional regulator
E0W69_009925	COG2814	Major facilitator Superfamily
E0W69_009935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E0W69_009955	COG1104	cysteine desulfurase activity
E0W69_009960	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_010025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E0W69_010045	COG1132	(ABC) transporter
E0W69_010055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E0W69_010060	COG0823	Involved in the tonB-independent uptake of proteins
E0W69_010060	COG1506	peptidase
E0W69_010065	COG2195	Cleaves the N-terminal amino acid of tripeptides
E0W69_010070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E0W69_010075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E0W69_010085	COG0450	alkyl hydroperoxide reductase
E0W69_010090	COG0588	phosphoglycerate mutase activity
E0W69_010105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E0W69_010110	COG2211	Major facilitator Superfamily
E0W69_010135	COG1247	-acetyltransferase
E0W69_010145	COG0519	Catalyzes the synthesis of GMP from XMP
E0W69_010160	COG4206	TonB-dependent receptor
E0W69_010160	COG1629	transport
E0W69_010170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_010195	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
E0W69_010200	COG1091	dTDP-4-dehydrorhamnose reductase activity
E0W69_010225	COG0560	Phosphoserine phosphatase
E0W69_010230	COG0583	DNA-binding transcription factor activity
E0W69_010235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_010255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_010280	COG0028	Belongs to the TPP enzyme family
E0W69_010285	COG3527	Alpha-acetolactate decarboxylase
E0W69_010290	COG0247	lactate metabolic process
E0W69_010295	COG1139	Iron-sulfur cluster binding protein
E0W69_010305	COG0702	epimerase
E0W69_010310	COG4221	oxidoreductase activity
E0W69_010325	COG0306	phosphate transporter
E0W69_010350	COG0463	Glycosyl transferase, family 2
E0W69_010350	COG1216	Glycosyl transferase, family 2
E0W69_010370	COG0045	succinate-CoA ligase (ADP-forming) activity
E0W69_010380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E0W69_010385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E0W69_010390	COG2989	Protein conserved in bacteria
E0W69_010395	COG1064	alcohol dehydrogenase
E0W69_010400	COG0859	PFAM glycosyl transferase family 9
E0W69_010425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0W69_010430	COG1104	cysteine desulfurase activity
E0W69_010440	COG0653	protein targeting
E0W69_010445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E0W69_010450	COG0564	pseudouridine synthase activity
E0W69_010480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0W69_010505	COG0025	NhaP-type Na H and K H
E0W69_010520	COG0539	negative regulation of cytoplasmic translation
E0W69_010525	COG2721	sulfolactate sulfo-lyase activity
E0W69_010535	COG3618	amidohydrolase
E0W69_010540	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0W69_010545	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_010550	COG3254	rhamnose metabolic process
E0W69_010555	COG0738	Major facilitator superfamily
E0W69_010565	COG1136	(ABC) transporter
E0W69_010575	COG1136	(ABC) transporter
E0W69_010575	COG0577	efflux transmembrane transporter activity
E0W69_010580	COG0577	efflux transmembrane transporter activity
E0W69_010595	COG0577	efflux transmembrane transporter activity
E0W69_010605	COG0577	efflux transmembrane transporter activity
E0W69_010605	COG1136	(ABC) transporter
E0W69_010615	COG1136	(ABC) transporter
E0W69_010620	COG1136	(ABC) transporter
E0W69_010620	COG0577	efflux transmembrane transporter activity
E0W69_010625	COG0577	efflux transmembrane transporter activity
E0W69_010630	COG0577	efflux transmembrane transporter activity
E0W69_010650	COG3852	Histidine kinase
E0W69_010665	COG1629	transport
E0W69_010665	COG4206	TonB-dependent receptor
E0W69_010670	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E0W69_010690	COG3250	beta-galactosidase activity
E0W69_010720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E0W69_010735	COG0583	DNA-binding transcription factor activity
E0W69_010770	COG4948	Mandelate Racemase Muconate Lactonizing
E0W69_010790	COG4206	TonB-dependent receptor
E0W69_010790	COG1629	transport
E0W69_010815	COG4206	TonB-dependent receptor
E0W69_010815	COG1629	transport
E0W69_010835	COG3250	beta-galactosidase activity
E0W69_010850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0W69_010860	COG0531	amino acid
E0W69_010865	COG3938	Belongs to the proline racemase family
E0W69_010875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0W69_010880	COG2207	Transcriptional regulator
E0W69_010885	COG0604	alcohol dehydrogenase
E0W69_010890	COG0300	oxidoreductase activity
E0W69_010930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0W69_010935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E0W69_010940	COG0019	diaminopimelate decarboxylase activity
E0W69_010990	COG0038	chloride channel
E0W69_011015	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0W69_011025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E0W69_011030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E0W69_011040	COG2226	methyltransferase
E0W69_011045	COG0066	3-isopropylmalate dehydratase activity
E0W69_011050	COG1119	ATPase activity
E0W69_011055	COG0473	3-isopropylmalate dehydrogenase activity
E0W69_011060	COG0129	dihydroxy-acid dehydratase activity
E0W69_011065	COG0028	Belongs to the TPP enzyme family
E0W69_011070	COG0440	acetolactate synthase activity
E0W69_011075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E0W69_011085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0W69_011090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E0W69_011100	COG0438	transferase activity, transferring glycosyl groups
E0W69_011130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E0W69_011135	COG1215	transferase activity, transferring glycosyl groups
E0W69_011150	COG1216	Glycosyl transferase, family 2
E0W69_011160	COG1216	Glycosyl transferase, family 2
E0W69_011160	COG1442	glycosyl transferase family 8
E0W69_011180	COG0028	Belongs to the TPP enzyme family
E0W69_011195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E0W69_011210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E0W69_011225	COG2255	four-way junction helicase activity
E0W69_011230	COG0295	cytidine deaminase activity
E0W69_011240	COG0071	Belongs to the small heat shock protein (HSP20) family
E0W69_011245	COG1074	ATP-dependent DNA helicase activity
E0W69_011250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E0W69_011275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E0W69_011280	COG3590	peptidase
E0W69_011335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0W69_011355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0W69_011365	COG4221	oxidoreductase activity
E0W69_011370	COG1322	Protein conserved in bacteria
E0W69_011390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E0W69_011395	COG1053	succinate dehydrogenase
E0W69_011410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0W69_011440	COG0681	Belongs to the peptidase S26 family
E0W69_011445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E0W69_011445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E0W69_011450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0W69_011465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E0W69_011475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E0W69_011480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E0W69_011485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E0W69_011495	COG0287	Prephenate dehydrogenase
E0W69_011505	COG1605	Chorismate mutase
E0W69_011505	COG0077	Prephenate dehydratase
E0W69_011510	COG0300	oxidoreductase activity
E0W69_011515	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E0W69_011525	COG0281	malic enzyme
E0W69_011525	COG0280	phosphate acetyltransferase
E0W69_011550	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0W69_011560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E0W69_011570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E0W69_011585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0W69_011595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0W69_011630	COG0542	response to heat
E0W69_011635	COG0205	6-phosphofructokinase activity
E0W69_011640	COG0469	pyruvate kinase activity
E0W69_011650	COG1959	2 iron, 2 sulfur cluster binding
E0W69_011655	COG0025	NhaP-type Na H and K H
E0W69_011665	COG3537	Alpha-1,2-mannosidase
E0W69_011670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E0W69_011675	COG0004	ammonium transporteR
E0W69_011695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E0W69_011700	COG0737	Belongs to the 5'-nucleotidase family
E0W69_011725	COG0562	UDP-galactopyranose mutase
E0W69_011780	COG1215	transferase activity, transferring glycosyl groups
E0W69_011790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E0W69_011820	COG0534	Mate efflux family protein
E0W69_011825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E0W69_011830	COG2050	protein possibly involved in aromatic compounds catabolism
E0W69_011840	COG5487	UPF0391 membrane protein
E0W69_011845	COG0415	Belongs to the DNA photolyase family
E0W69_011860	COG1185	polyribonucleotide nucleotidyltransferase activity
E0W69_011890	COG2321	neutral zinc metallopeptidase
E0W69_011900	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E0W69_011905	COG4974	Belongs to the 'phage' integrase family
E0W69_011910	COG1968	undecaprenyl-diphosphatase activity
E0W69_011915	COG2270	Major facilitator Superfamily
E0W69_011920	COG0254	rRNA binding
E0W69_011925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0W69_011985	COG0318	PFAM AMP-dependent synthetase and ligase
E0W69_011995	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E0W69_012000	COG5492	domain, Protein
E0W69_012015	COG1252	NADH dehydrogenase
E0W69_012045	COG0738	Major facilitator superfamily
E0W69_012050	COG0700	Nucleoside recognition
E0W69_012055	COG0705	Rhomboid family
E0W69_012060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0W69_012070	COG1999	signal sequence binding
E0W69_012075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0W69_012080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0W69_012095	COG2197	response regulator
E0W69_012115	COG3842	ATPase activity
E0W69_012120	COG0791	NLP P60 protein
E0W69_012125	COG0516	GMP reductase activity
E0W69_012125	COG0517	IMP dehydrogenase activity
E0W69_012130	COG0758	DNA mediated transformation
E0W69_012155	COG1160	GTP binding
E0W69_012160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E0W69_012175	COG0022	dehydrogenase e1 component
E0W69_012175	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0W69_012180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0W69_012195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E0W69_012225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E0W69_012230	COG1522	sequence-specific DNA binding
E0W69_012240	COG0346	lactoylglutathione lyase activity
E0W69_012260	COG2312	Erythromycin esterase
E0W69_012275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E0W69_012285	COG1024	Enoyl-CoA hydratase
E0W69_012285	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0W69_012290	COG0183	Belongs to the thiolase family
E0W69_012295	COG1960	acyl-CoA dehydrogenase activity
E0W69_012300	COG2086	electron transfer activity
E0W69_012305	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E0W69_012310	COG1022	Amp-dependent synthetase and ligase
E0W69_012360	COG1012	belongs to the aldehyde dehydrogenase family
E0W69_012385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0W69_012400	COG4452	Inner membrane protein CreD
E0W69_012410	COG2095	MarC family integral membrane protein
E0W69_012420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E0W69_012430	COG1309	transcriptional regulator
E0W69_012435	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_012440	COG2814	Major facilitator Superfamily
E0W69_012445	COG1309	transcriptional regulator
E0W69_012505	COG0346	lactoylglutathione lyase activity
E0W69_012520	COG4206	TonB-dependent receptor
E0W69_012525	COG2176	DNA-directed DNA polymerase activity
E0W69_012540	COG1733	regulation of RNA biosynthetic process
E0W69_012550	COG1064	alcohol dehydrogenase
E0W69_012570	COG0246	Mannitol dehydrogenase
E0W69_012575	COG4095	Psort location CytoplasmicMembrane, score
E0W69_012580	COG0339	signal peptide processing
E0W69_012600	COG1418	mRNA catabolic process
E0W69_012605	COG0126	phosphoglycerate kinase activity
E0W69_012610	COG3239	Fatty acid desaturase
E0W69_012615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E0W69_012635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E0W69_012645	COG0196	riboflavin kinase activity
E0W69_012650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E0W69_012665	COG1609	Transcriptional regulator
E0W69_012670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0W69_012675	COG1082	Xylose isomerase domain protein TIM barrel
E0W69_012730	COG0101	tRNA pseudouridine synthase activity
E0W69_012740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E0W69_012745	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E0W69_012755	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E0W69_012760	COG0336	Belongs to the RNA methyltransferase TrmD family
E0W69_012765	COG1629	transport
E0W69_012765	COG4206	TonB-dependent receptor
E0W69_012770	COG0561	phosphatase activity
E0W69_012785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E0W69_012810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E0W69_012820	COG1132	(ABC) transporter
E0W69_012825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E0W69_012830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E0W69_012835	COG0149	triose-phosphate isomerase activity
E0W69_012870	COG0322	excinuclease ABC activity
E0W69_012880	COG1472	Belongs to the glycosyl hydrolase 3 family
E0W69_012890	COG2814	Major facilitator Superfamily
E0W69_012905	COG0791	NLP P60 protein
E0W69_012905	COG1388	LysM domain
E0W69_012920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0W69_012925	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E0W69_012935	COG0248	Ppx GppA phosphatase
E0W69_012940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E0W69_012950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E0W69_012960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E0W69_012965	COG1231	oxidoreductase activity
E0W69_012975	COG0724	RNA recognition motif
E0W69_012980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
E0W69_012990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E0W69_013010	COG0667	Aldo Keto reductase
E0W69_013015	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E0W69_013025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E0W69_013035	COG1187	pseudouridine synthase activity
E0W69_013040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E0W69_013045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E0W69_013050	COG0052	Belongs to the universal ribosomal protein uS2 family
E0W69_013055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E0W69_013085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E0W69_013100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0W69_013110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E0W69_013140	COG1629	transport
E0W69_013140	COG4206	TonB-dependent receptor
E0W69_013160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E0W69_013170	COG0113	porphobilinogen synthase activity
E0W69_013175	COG0408	coproporphyrinogen oxidase activity
E0W69_013180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E0W69_013190	COG0181	hydroxymethylbilane synthase activity
E0W69_013195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E0W69_013220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0W69_013225	COG4948	Mandelate Racemase Muconate Lactonizing
E0W69_013240	COG4774	siderophore transport
E0W69_013255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E0W69_013285	COG0358	DNA primase activity
E0W69_013295	COG1595	DNA-templated transcription, initiation
E0W69_013305	COG2363	Small membrane protein
E0W69_013310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E0W69_013325	COG1090	epimerase
E0W69_013350	COG0561	phosphatase activity
E0W69_013355	COG1629	transport
E0W69_013355	COG4206	TonB-dependent receptor
E0W69_013380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E0W69_013390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E0W69_013400	COG1234	tRNA 3'-trailer cleavage
E0W69_013410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E0W69_013415	COG1305	Transglutaminase-like
E0W69_013425	COG2308	Evidence 4 Homologs of previously reported genes of
E0W69_013430	COG1309	transcriptional regulator
E0W69_013435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0W69_013435	COG3153	acetyltransferase
E0W69_013440	COG3956	TIGRFAM MazG family protein
E0W69_013445	COG5000	phosphorelay sensor kinase activity
E0W69_013450	COG4260	virion core protein, lumpy skin disease virus
E0W69_013480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E0W69_013485	COG1228	amidohydrolase
E0W69_013490	COG0792	nuclease activity
E0W69_013495	COG1482	cell wall glycoprotein biosynthetic process
E0W69_013505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E0W69_013510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E0W69_013555	COG0602	queuosine metabolic process
E0W69_013560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E0W69_013570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E0W69_013575	COG1136	(ABC) transporter
E0W69_013575	COG0577	efflux transmembrane transporter activity
E0W69_013595	COG0582	viral genome integration into host DNA
E0W69_013615	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E0W69_013615	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E0W69_013620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E0W69_013625	COG3177	Filamentation induced by cAMP protein fic
E0W69_013650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E0W69_013785	COG4584	PFAM Integrase catalytic
E0W69_013785	COG2390	Transcriptional regulator
E0W69_013790	COG1484	DNA-dependent DNA replication
E0W69_013810	COG4206	TonB-dependent receptor
E0W69_013810	COG1629	transport
E0W69_013815	COG4372	Transposase
E0W69_013855	COG0531	amino acid
E0W69_013865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0W69_013870	COG0166	Belongs to the GPI family
E0W69_013895	COG1418	mRNA catabolic process
E0W69_013920	COG1522	sequence-specific DNA binding
E0W69_013930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E0W69_013930	COG0116	Belongs to the methyltransferase superfamily
E0W69_013950	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
E0W69_013955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0W69_013980	COG1629	transport
E0W69_013980	COG4206	TonB-dependent receptor
E0W69_013985	COG1940	carbohydrate kinase activity
E0W69_013995	COG0363	glucosamine-6-phosphate deaminase activity
E0W69_014005	COG1253	flavin adenine dinucleotide binding
E0W69_014025	COG2003	Belongs to the UPF0758 family
E0W69_014035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E0W69_014040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E0W69_014045	COG0193	aminoacyl-tRNA hydrolase activity
E0W69_014050	COG1289	transmembrane transporter activity
E0W69_014065	COG0316	Belongs to the HesB IscA family
E0W69_014075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E0W69_014080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E0W69_014090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E0W69_014095	COG0505	Belongs to the CarA family
E0W69_014130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E0W69_014140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E0W69_014145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0W69_014150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E0W69_014155	COG0195	Participates in both transcription termination and antitermination
E0W69_014155	COG2251	uridine kinase activity
E0W69_014160	COG0779	Required for maturation of 30S ribosomal subunits
E0W69_014170	COG1011	Hydrolase
E0W69_014210	COG0791	NLP P60 protein
E0W69_014220	COG0357	Ribosomal RNA small subunit methyltransferase G
E0W69_014225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E0W69_014230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E0W69_014245	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E0W69_014245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0W69_014250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0W69_014255	COG1078	dGTPase activity
E0W69_014260	COG2204	response regulator
E0W69_014275	COG0416	fatty acid biosynthetic process
E0W69_014285	COG0285	dihydrofolate synthase activity
E0W69_014295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0W69_014300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E0W69_014315	COG0860	N-Acetylmuramoyl-L-alanine amidase
E0W69_014330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E0W69_014345	COG2706	6-phosphogluconolactonase activity
E0W69_014350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E0W69_014365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E0W69_014370	COG1660	Displays ATPase and GTPase activities
E0W69_014375	COG1331	Highly conserved protein containing a thioredoxin domain
E0W69_014385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E0W69_014390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E0W69_014395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E0W69_014400	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E0W69_014405	COG0356	it plays a direct role in the translocation of protons across the membrane
E0W69_014415	COG0730	response to heat
E0W69_014425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_014440	COG1629	transport
E0W69_014440	COG4206	TonB-dependent receptor
E0W69_014460	COG4206	TonB-dependent receptor
E0W69_014460	COG1629	transport
E0W69_014470	COG1595	DNA-templated transcription, initiation
E0W69_014480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E0W69_014505	COG3511	phospholipase C
E0W69_014545	COG4206	TonB-dependent receptor
E0W69_014545	COG1629	transport
E0W69_014585	COG3250	beta-galactosidase activity
E0W69_014590	COG4124	Belongs to the glycosyl hydrolase 26 family
E0W69_014595	COG3345	alpha-galactosidase
E0W69_014610	COG2942	2-epimerase
E0W69_014615	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
E0W69_014620	COG2211	Major facilitator Superfamily
E0W69_014635	COG1629	transport
E0W69_014635	COG4206	TonB-dependent receptor
E0W69_014650	COG4206	TonB-dependent receptor
E0W69_014650	COG1629	transport
E0W69_014655	COG0584	glycerophosphoryl diester phosphodiesterase
E0W69_014675	COG0084	hydrolase, TatD family'
E0W69_014715	COG0667	Aldo Keto reductase
E0W69_014725	COG0673	inositol 2-dehydrogenase activity
E0W69_014765	COG0326	Molecular chaperone. Has ATPase activity
E0W69_014775	COG0351	phosphomethylpyrimidine kinase
E0W69_014805	COG0714	Associated with various cellular activities
E0W69_014810	COG1305	Transglutaminase-like
E0W69_014830	COG0583	DNA-binding transcription factor activity
E0W69_014855	COG0025	NhaP-type Na H and K H
E0W69_014885	COG0714	Associated with various cellular activities
E0W69_014895	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E0W69_014905	COG3104	oligopeptide transport
E0W69_014910	COG0151	Belongs to the GarS family
E0W69_014920	COG1077	Cell shape determining protein MreB Mrl
E0W69_014935	COG0768	penicillin binding
E0W69_014940	COG0772	Belongs to the SEDS family
E0W69_014945	COG0563	adenylate kinase activity
E0W69_014965	COG0497	DNA recombination
E0W69_014980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0W69_015005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E0W69_015015	COG0612	Peptidase, M16
E0W69_015035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0W69_015050	COG3655	Transcriptional regulator
E0W69_015065	COG0085	RNA polymerase activity
E0W69_015075	COG0531	amino acid
E0W69_015100	COG0321	lipoyl(octanoyl) transferase activity
E0W69_015105	COG0564	pseudouridine synthase activity
E0W69_015120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E0W69_015130	COG0300	oxidoreductase activity
E0W69_015145	COG4206	TonB-dependent receptor
E0W69_015195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E0W69_015200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0W69_015210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E0W69_015215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0W69_015225	COG2363	Small membrane protein
E0W69_015230	COG1619	proteins homologs of microcin C7 resistance protein MccF
E0W69_015235	COG1619	proteins homologs of microcin C7 resistance protein MccF
E0W69_015240	COG1960	acyl-CoA dehydrogenase activity
E0W69_015245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0W69_015245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0W69_015255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E0W69_015260	COG0251	oxidation-reduction process
E0W69_015270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0W69_015280	COG4771	TonB-dependent receptor
E0W69_015305	COG0793	Belongs to the peptidase S41A family
E0W69_015310	COG1607	acyl-coa hydrolase
E0W69_015325	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_015345	COG0300	oxidoreductase activity
E0W69_015350	COG2207	Transcriptional regulator
E0W69_015350	COG0662	Cupin 2, conserved barrel domain protein
E0W69_015370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E0W69_015375	COG2315	Protein conserved in bacteria
E0W69_015395	COG0460	homoserine dehydrogenase
E0W69_015400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0W69_015405	COG2885	chlorophyll binding
E0W69_015425	COG1610	YqeY-like protein
E0W69_015440	COG4206	TonB-dependent receptor
E0W69_015445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E0W69_015460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E0W69_015460	COG0321	lipoyl(octanoyl) transferase activity
E0W69_015480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0W69_015490	COG0656	L-ascorbic acid biosynthetic process
E0W69_015495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E0W69_015510	COG0571	ribonuclease III activity
E0W69_015515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0W69_015520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0W69_015525	COG2153	protein acetylation
E0W69_015540	COG4206	TonB-dependent receptor
E0W69_015540	COG1629	transport
E0W69_015555	COG3387	PFAM Glycoside hydrolase 15-related
E0W69_015560	COG0519	Catalyzes the synthesis of GMP from XMP
E0W69_015560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E0W69_015565	COG0268	Binds directly to 16S ribosomal RNA
E0W69_015570	COG0567	Dehydrogenase, E1 component
E0W69_015575	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0W69_015580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0W69_015590	COG1862	Preprotein translocase
E0W69_015595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E0W69_015600	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E0W69_015600	COG0662	Cupin 2, conserved barrel domain protein
E0W69_015620	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E0W69_015625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E0W69_015630	COG1136	(ABC) transporter
E0W69_015640	COG0028	Belongs to the TPP enzyme family
E0W69_015650	COG2354	Protein conserved in bacteria
E0W69_015665	COG1063	alcohol dehydrogenase
E0W69_015670	COG0439	Biotin carboxylase
E0W69_015675	COG0511	ligase activity, forming carbon-carbon bonds
E0W69_015680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E0W69_015700	COG1796	DNA polymerase
E0W69_015700	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E0W69_015710	COG0477	Major facilitator Superfamily
E0W69_015715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E0W69_015735	COG3781	membrane
E0W69_015740	COG5002	protein histidine kinase activity
E0W69_015745	COG0745	RESPONSE REGULATOR receiver
E0W69_015785	COG2837	iron assimilation
E0W69_015800	COG1764	response to oxidative stress
E0W69_015805	COG0025	NhaP-type Na H and K H
E0W69_015830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0W69_015835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E0W69_015840	COG0688	phosphatidylethanolamine metabolic process
E0W69_015845	COG4589	Belongs to the CDS family
E0W69_015890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E0W69_015900	COG1335	isochorismatase
E0W69_015915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E0W69_015915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0W69_015925	COG2204	response regulator
E0W69_016005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E0W69_016010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E0W69_016020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E0W69_016040	COG1733	regulation of RNA biosynthetic process
E0W69_016045	COG2814	Major facilitator Superfamily
E0W69_016065	COG1794	racemase activity, acting on amino acids and derivatives
E0W69_016080	COG2070	2-Nitropropane dioxygenase
E0W69_016090	COG0339	signal peptide processing
E0W69_016095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0W69_016130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E0W69_016160	COG0628	permease
E0W69_016165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E0W69_016170	COG0632	four-way junction helicase activity
E0W69_016245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E0W69_016265	COG1047	Peptidyl-prolyl cis-trans
E0W69_016270	COG3876	Protein conserved in bacteria
E0W69_016290	COG0492	ferredoxin-NADP+ reductase activity
E0W69_016295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E0W69_016300	COG0484	heat shock protein binding
E0W69_016310	COG4948	Mandelate Racemase Muconate Lactonizing
E0W69_016315	COG1070	Carbohydrate kinase
E0W69_016325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0W69_016335	COG0616	signal peptide processing
E0W69_016345	COG1428	Deoxynucleoside kinase
E0W69_016365	COG1162	GTPase activity
E0W69_016370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E0W69_016375	COG1970	mechanosensitive ion channel activity
E0W69_016390	COG0233	cytoplasmic translational termination
E0W69_016395	COG3959	Transketolase, thiamine diphosphate binding domain
E0W69_016415	COG0556	nucleotide-excision repair
E0W69_016460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E0W69_016470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E0W69_016530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E0W69_016535	COG0598	Magnesium transport protein CorA
E0W69_016540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0W69_016545	COG0584	glycerophosphoryl diester phosphodiesterase
E0W69_016560	COG1595	DNA-templated transcription, initiation
E0W69_016590	COG0686	Belongs to the AlaDH PNT family
E0W69_016600	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E0W69_016605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E0W69_016620	COG0805	protein transport
E0W69_016635	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E0W69_016645	COG0529	Catalyzes the synthesis of activated sulfate
E0W69_016660	COG1131	(ABC) transporter
E0W69_016675	COG3177	Filamentation induced by cAMP protein fic
E0W69_016680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E0W69_016700	COG4771	TonB-dependent receptor
E0W69_016730	COG1960	acyl-CoA dehydrogenase activity
E0W69_016755	COG1629	transport
E0W69_016755	COG4206	TonB-dependent receptor
E0W69_016765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_016770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_016775	COG3738	Protein conserved in bacteria
E0W69_016780	COG2076	Multidrug Resistance protein
E0W69_016795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E0W69_016805	COG0667	Aldo Keto reductase
E0W69_016810	COG2610	gluconate transmembrane transporter activity
E0W69_016835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E0W69_016840	COG0017	Asparaginyl-tRNA synthetase
E0W69_016855	COG0494	nUDIX hydrolase
E0W69_016910	COG1129	ABC transporter
E0W69_016915	COG0667	Aldo Keto reductase
E0W69_016940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E0W69_016975	COG0423	glycine-tRNA ligase activity
E0W69_016980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0W69_016985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0W69_016985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0W69_017015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0W69_017025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0W69_017030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0W69_017035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E0W69_017065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E0W69_017090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E0W69_017100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E0W69_017155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E0W69_017160	COG1247	-acetyltransferase
E0W69_017180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_017185	COG3279	Response regulator of the LytR AlgR family
E0W69_017190	COG3275	phosphorelay sensor kinase activity
E0W69_017200	COG0724	RNA recognition motif
E0W69_017205	COG0475	glutathione-regulated potassium exporter activity
E0W69_017205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0W69_017215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E0W69_017225	COG0071	Belongs to the small heat shock protein (HSP20) family
E0W69_017230	COG0693	protein deglycase activity
E0W69_017230	COG0753	catalase activity
E0W69_017265	COG2003	Belongs to the UPF0758 family
E0W69_017340	COG4206	TonB-dependent receptor
E0W69_017340	COG1629	transport
E0W69_017365	COG4804	nuclease activity
E0W69_017390	COG0307	riboflavin synthase, alpha
E0W69_017395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E0W69_017410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0W69_017420	COG3011	Protein conserved in bacteria
E0W69_017435	COG0215	cysteine-tRNA ligase activity
E0W69_017440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E0W69_017445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E0W69_017465	COG2884	Cell division ATP-binding protein ftsE
E0W69_017470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E0W69_017505	COG0445	tRNA wobble uridine modification
E0W69_017510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E0W69_017520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E0W69_017530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E0W69_017535	COG2146	nitrite reductase [NAD(P)H] activity
E0W69_017540	COG0592	DNA-directed DNA polymerase activity
E0W69_017555	COG4206	TonB-dependent receptor
E0W69_017555	COG1629	transport
E0W69_017575	COG4206	TonB-dependent receptor
E0W69_017575	COG1629	transport
E0W69_017585	COG4206	TonB-dependent receptor
E0W69_017585	COG1629	transport
E0W69_017600	COG3340	Belongs to the peptidase S51 family
E0W69_017610	COG3279	Response regulator of the LytR AlgR family
E0W69_017615	COG0745	RESPONSE REGULATOR receiver
E0W69_017615	COG2972	Histidine kinase
E0W69_017630	COG1554	hydrolase, family 65, central catalytic
E0W69_017635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0W69_017640	COG0366	Alpha amylase catalytic
E0W69_017650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E0W69_017655	COG4206	TonB-dependent receptor
E0W69_017655	COG1629	transport
E0W69_017665	COG1082	Xylose isomerase domain protein TIM barrel
E0W69_017680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E0W69_017690	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E0W69_017695	COG0384	phenazine biosynthesis protein PhzF
E0W69_017700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E0W69_017715	COG0302	gtp cyclohydrolase
E0W69_017725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E0W69_017740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E0W69_017745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E0W69_017750	COG0363	glucosamine-6-phosphate deaminase activity
E0W69_017755	COG0116	Belongs to the methyltransferase superfamily
E0W69_017755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E0W69_017785	COG2264	protein methyltransferase activity
E0W69_017805	COG1760	l-serine dehydratase
E0W69_017840	COG2860	membrane
E0W69_017845	COG0579	oxidoreductase
E0W69_017850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E0W69_017855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E0W69_017860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E0W69_017865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E0W69_017870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E0W69_017875	COG0202	RNA polymerase activity
E0W69_017880	COG0203	ribosomal protein L17
E0W69_017895	COG1132	(ABC) transporter
E0W69_017905	COG1183	phosphatidylcholine synthase activity
E0W69_017910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E0W69_017925	COG1136	(ABC) transporter
E0W69_017930	COG2096	Adenosyltransferase
E0W69_017950	COG0437	4 iron, 4 sulfur cluster binding
E0W69_017975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E0W69_017980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0W69_017985	COG0109	protoheme IX farnesyltransferase activity
E0W69_017990	COG1845	cytochrome c oxidase, subunit III
E0W69_018025	COG0673	inositol 2-dehydrogenase activity
E0W69_018050	COG1349	DNA-binding transcription factor activity
E0W69_018055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E0W69_018060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E0W69_018065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E0W69_018075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E0W69_018080	COG1522	sequence-specific DNA binding
E0W69_018090	COG1138	Cytochrome C-type biogenesis protein
E0W69_018120	COG4206	TonB-dependent receptor
E0W69_018120	COG1629	transport
E0W69_018145	COG1597	lipid kinase activity
E0W69_018160	COG4654	Cytochrome c, class I
E0W69_018165	COG0436	Aminotransferase
E0W69_018180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0W69_018215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E0W69_018220	COG1247	-acetyltransferase
E0W69_018235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E0W69_018270	COG0438	transferase activity, transferring glycosyl groups
E0W69_018280	COG1216	Glycosyl transferase, family 2
E0W69_018280	COG0438	transferase activity, transferring glycosyl groups
E0W69_018295	COG1132	(ABC) transporter
E0W69_018325	COG0405	Gamma-glutamyltransferase
E0W69_018340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_018345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E0W69_018345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0W69_018355	COG1830	Aldolase
E0W69_018360	COG3250	beta-galactosidase activity
E0W69_018365	COG0051	transcription antitermination factor activity, RNA binding
E0W69_018370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E0W69_018375	COG0088	Forms part of the polypeptide exit tunnel
E0W69_018380	COG0089	rRNA binding
E0W69_018385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E0W69_018390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E0W69_018395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E0W69_018400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E0W69_018405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E0W69_018410	COG0255	Belongs to the universal ribosomal protein uL29 family
E0W69_018415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E0W69_018420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E0W69_018425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E0W69_018430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E0W69_018435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E0W69_018440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E0W69_018445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E0W69_018450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E0W69_018455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E0W69_018460	COG1841	ribosomal large subunit assembly
E0W69_018465	COG0200	Binds to the 23S rRNA
E0W69_018480	COG2081	HI0933 family
E0W69_018500	COG1940	carbohydrate kinase activity
E0W69_018505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E0W69_018510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E0W69_018520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E0W69_018525	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_018530	COG1137	ATPase activity
E0W69_018535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E0W69_018565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E0W69_018570	COG2234	aminopeptidase activity
E0W69_018575	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E0W69_018575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0W69_018590	COG3142	Participates in the control of copper homeostasis
E0W69_018595	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E0W69_018595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E0W69_018610	COG3265	gluconokinase activity
E0W69_018625	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E0W69_018630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0W69_018630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0W69_018635	COG0788	formyltetrahydrofolate deformylase activity
E0W69_018655	COG1040	competence protein
E0W69_018665	COG0386	Belongs to the glutathione peroxidase family
E0W69_018670	COG0470	DNA polymerase III
E0W69_018675	COG1774	PSP1 C-terminal conserved region
E0W69_018690	COG3275	phosphorelay sensor kinase activity
E0W69_018695	COG3279	Response regulator of the LytR AlgR family
E0W69_018700	COG3384	dioxygenase
E0W69_018730	COG4974	Belongs to the 'phage' integrase family
E0W69_018735	COG0083	homoserine kinase activity
E0W69_018740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0W69_018750	COG1131	(ABC) transporter
E0W69_018775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0W69_018785	COG0799	negative regulation of ribosome biogenesis
E0W69_018790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0W69_018805	COG0668	transmembrane transport
E0W69_018810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E0W69_018825	COG1528	Iron-storage protein
E0W69_018830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E0W69_018835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_018850	COG0009	L-threonylcarbamoyladenylate synthase
E0W69_018855	COG0069	glutamate synthase activity
E0W69_018875	COG0509	glycine decarboxylation via glycine cleavage system
E0W69_018880	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
E0W69_018900	COG4206	TonB-dependent receptor
E0W69_018900	COG1629	transport
E0W69_018935	COG1704	LemA family
E0W69_018940	COG0450	alkyl hydroperoxide reductase
E0W69_018945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0W69_018960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E0W69_018965	COG3590	peptidase
E0W69_018975	COG0528	UMP kinase activity
E0W69_018980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E0W69_018985	COG1595	DNA-templated transcription, initiation
E0W69_018990	COG1472	Belongs to the glycosyl hydrolase 3 family
E0W69_019000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E0W69_019025	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E0W69_019040	COG1194	a g-specific adenine glycosylase
E0W69_019050	COG0542	response to heat
E0W69_019055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E0W69_019100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E0W69_019135	COG3279	Response regulator of the LytR AlgR family
E0W69_019140	COG3275	phosphorelay sensor kinase activity
E0W69_019145	COG1136	(ABC) transporter
E0W69_019155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0W69_019170	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
E0W69_019190	COG1538	Outer membrane efflux protein
E0W69_019195	COG1028	Short-chain dehydrogenase reductase Sdr
E0W69_019200	COG1501	Belongs to the glycosyl hydrolase 31 family
E0W69_019230	COG1629	transport
E0W69_019230	COG4206	TonB-dependent receptor
E0W69_019240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E0W69_019265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E0W69_019275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E0W69_019290	COG3541	Predicted nucleotidyltransferase
E0W69_019335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E0W69_019360	COG1649	PFAM Uncharacterised BCR, COG1649
E0W69_019390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0W69_019420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E0W69_019445	COG1678	Uncharacterized ACR, COG1678
E0W69_019480	COG0343	queuine tRNA-ribosyltransferase activity
E0W69_019485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E0W69_019495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E0W69_019520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0W69_019530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E0W69_019540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E0W69_019560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E0W69_019565	COG0433	COG0433 Predicted ATPase
E0W69_019570	COG0673	inositol 2-dehydrogenase activity
E0W69_019575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E0W69_019590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E0W69_019610	COG0811	peptide transport
E0W69_019615	COG0848	biopolymer transport protein
E0W69_019620	COG0629	single-stranded DNA binding
E0W69_019640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0W69_019645	COG4152	abc transporter atp-binding protein
E0W69_019650	COG1668	transmembrane transport
E0W69_019660	COG1335	isochorismatase
E0W69_019665	COG1193	negative regulation of DNA recombination
E0W69_019675	COG1252	NADH dehydrogenase
E0W69_019685	COG0477	Major facilitator Superfamily
E0W69_019700	COG4206	TonB-dependent receptor
E0W69_019700	COG1629	transport
E0W69_019710	COG1739	Uncharacterized protein family UPF0029
E0W69_019715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0W69_019715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0W69_019720	COG2890	protein-(glutamine-N5) methyltransferase activity
E0W69_019725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0W69_019745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0W69_019760	COG0793	Belongs to the peptidase S41A family
E0W69_019795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E0W69_019810	COG0594	ribonuclease P activity
E0W69_019815	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E0W69_019835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E0W69_019840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E0W69_019850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0W69_019855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0W69_019860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E0W69_019865	COG0049	tRNA binding
E0W69_019870	COG2333	competence protein COMEC
E0W69_019870	COG0658	competence protein
E0W69_019875	COG0138	bifunctional purine biosynthesis protein purh
E0W69_019885	COG0671	phosphoesterase, PA-phosphatase related
E0W69_019895	COG2132	Multicopper oxidase
E0W69_019910	COG2217	Heavy metal translocating P-type atpase
E0W69_019925	COG4656	Part of a membrane complex involved in electron transport
E0W69_019940	COG2814	Major facilitator Superfamily
E0W69_019950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E0W69_019955	COG0540	Belongs to the ATCase OTCase family
E0W69_019960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E0W69_019970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E0W69_019980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E0W69_020015	COG0730	response to heat
E0W69_020020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E0W69_020020	COG1648	precorrin-2 dehydrogenase activity
E0W69_020035	COG0175	sulfate reduction
E0W69_020040	COG0175	sulfate reduction
E0W69_020050	COG3275	phosphorelay sensor kinase activity
E0W69_020055	COG3279	Response regulator of the LytR AlgR family
E0W69_020060	COG1956	GAF domain-containing protein
E0W69_020080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E0W69_020080	COG0392	lysyltransferase activity
E0W69_020100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E0W69_020115	COG0006	proline dipeptidase activity
E0W69_020135	COG0242	peptide deformylase activity
E0W69_020170	COG2814	Major facilitator Superfamily
E0W69_020180	COG0328	RNA-DNA hybrid ribonuclease activity
E0W69_020185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E0W69_020190	COG2001	Belongs to the MraZ family
E0W69_020195	COG0275	rRNA processing
E0W69_020210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E0W69_020215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0W69_020220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E0W69_020280	COG1192	Involved in chromosome partitioning