locus-tag	class	description
HMPREF9154_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HMPREF9154_0002	COG0592	DNA-directed DNA polymerase activity
HMPREF9154_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF9154_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HMPREF9154_0010	COG0187	DNA topoisomerase II activity
HMPREF9154_0011	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9154_0013	COG2814	Major facilitator Superfamily
HMPREF9154_0014	COG0640	Transcriptional regulator
HMPREF9154_0018	COG0747	negative chemotaxis
HMPREF9154_0019	COG0601	transmembrane transport
HMPREF9154_0020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_0023	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9154_0024	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9154_0025	COG1121	(ABC) transporter
HMPREF9154_0026	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF9154_0040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HMPREF9154_0041	COG0205	6-phosphofructokinase activity
HMPREF9154_0046	COG1131	(ABC) transporter
HMPREF9154_0052	COG1131	(ABC) transporter
HMPREF9154_0053	COG1309	transcriptional regulator
HMPREF9154_0061	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HMPREF9154_0061	COG0316	Belongs to the HesB IscA family
HMPREF9154_0065	COG0561	phosphatase activity
HMPREF9154_0072	COG2814	Major facilitator Superfamily
HMPREF9154_0073	COG0640	Transcriptional regulator
HMPREF9154_0078	COG3739	integral membrane protein
HMPREF9154_0079	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HMPREF9154_0081	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HMPREF9154_0103	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMPREF9154_0108	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HMPREF9154_0109	COG1116	anion transmembrane transporter activity
HMPREF9154_0114	COG1120	ATPase activity
HMPREF9154_0115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_0117	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_0122	COG1309	transcriptional regulator
HMPREF9154_0124	COG0667	Aldo Keto reductase
HMPREF9154_0128	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_0130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMPREF9154_0131	COG2197	response regulator
HMPREF9154_0144	COG3718	enzyme involved in inositol metabolism
HMPREF9154_0145	COG3962	Belongs to the TPP enzyme family
HMPREF9154_0155	COG1175	transmembrane transport
HMPREF9154_0156	COG0395	ABC-type sugar transport system, permease component
HMPREF9154_0161	COG0456	acetyltransferase
HMPREF9154_0164	COG1902	pentaerythritol trinitrate reductase activity
HMPREF9154_0168	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_0169	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_0172	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_0173	COG1879	ABC-type sugar transport system periplasmic component
HMPREF9154_0174	COG1609	Transcriptional regulator
HMPREF9154_0186	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_0191	COG3022	response to hydroperoxide
HMPREF9154_0194	COG0438	transferase activity, transferring glycosyl groups
HMPREF9154_0195	COG1132	(ABC) transporter
HMPREF9154_0198	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMPREF9154_0200	COG5002	protein histidine kinase activity
HMPREF9154_0201	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_0210	COG3266	domain, Protein
HMPREF9154_0216	COG1674	ftsk spoiiie
HMPREF9154_0226	COG1136	(ABC) transporter
HMPREF9154_0227	COG1131	(ABC) transporter
HMPREF9154_0230	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_0232	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HMPREF9154_0246	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_0250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HMPREF9154_0253	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF9154_0255	COG1309	transcriptional regulator
HMPREF9154_0257	COG2375	cellular response to nickel ion
HMPREF9154_0257	COG1132	(ABC) transporter
HMPREF9154_0258	COG1122	ATPase activity
HMPREF9154_0260	COG1129	ABC transporter
HMPREF9154_0262	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF9154_0263	COG1937	Protein conserved in bacteria
HMPREF9154_0267	COG0477	Major facilitator Superfamily
HMPREF9154_0271	COG2197	response regulator
HMPREF9154_0272	COG4585	Histidine kinase
HMPREF9154_0273	COG1131	(ABC) transporter
HMPREF9154_0283	COG1294	oxidase, subunit
HMPREF9154_0284	COG1271	oxidase subunit
HMPREF9154_0295	COG0300	oxidoreductase activity
HMPREF9154_0301	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMPREF9154_0303	COG1027	Aspartate ammonia-lyase
HMPREF9154_0304	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HMPREF9154_0305	COG1940	carbohydrate kinase activity
HMPREF9154_0307	COG1175	transmembrane transport
HMPREF9154_0308	COG0395	ABC-type sugar transport system, permease component
HMPREF9154_0309	COG1940	carbohydrate kinase activity
HMPREF9154_0315	COG0366	Alpha amylase catalytic
HMPREF9154_0321	COG2205	protein histidine kinase activity
HMPREF9154_0327	COG0022	dehydrogenase e1 component
HMPREF9154_0328	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9154_0329	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF9154_0332	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HMPREF9154_0337	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMPREF9154_0338	COG0561	phosphatase activity
HMPREF9154_0353	COG0494	nUDIX hydrolase
HMPREF9154_0363	COG2197	response regulator
HMPREF9154_0364	COG1136	(ABC) transporter
HMPREF9154_0364	COG0577	efflux transmembrane transporter activity
HMPREF9154_0365	COG1136	(ABC) transporter
HMPREF9154_0365	COG0577	efflux transmembrane transporter activity
HMPREF9154_0378	COG2226	methyltransferase
HMPREF9154_0386	COG2197	response regulator
HMPREF9154_0390	COG1205	dead DEAH box helicase
HMPREF9154_0390	COG1111	helicase
HMPREF9154_0395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HMPREF9154_0395	COG1648	precorrin-2 dehydrogenase activity
HMPREF9154_0408	COG1132	(ABC) transporter
HMPREF9154_0415	COG0406	alpha-ribazole phosphatase activity
HMPREF9154_0417	COG1595	DNA-templated transcription, initiation
HMPREF9154_0418	COG1252	NADH dehydrogenase
HMPREF9154_0421	COG0302	gtp cyclohydrolase
HMPREF9154_0422	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMPREF9154_0430	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HMPREF9154_0433	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9154_0434	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF9154_0436	COG1082	Xylose isomerase domain protein TIM barrel
HMPREF9154_0441	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF9154_0443	COG0406	alpha-ribazole phosphatase activity
HMPREF9154_0445	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_0448	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF9154_0451	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HMPREF9154_0454	COG1401	restriction endodeoxyribonuclease activity
HMPREF9154_0457	COG0406	alpha-ribazole phosphatase activity
HMPREF9154_0457	COG0494	nUDIX hydrolase
HMPREF9154_0458	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HMPREF9154_0459	COG0456	acetyltransferase
HMPREF9154_0460	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_0465	COG1490	D-aminoacyl-tRNA deacylase activity
HMPREF9154_0467	COG3485	protocatechuate 3,4-dioxygenase
HMPREF9154_0468	COG0354	folic acid binding
HMPREF9154_0472	COG2326	polyphosphate kinase activity
HMPREF9154_0475	COG0583	DNA-binding transcription factor activity
HMPREF9154_0481	COG1217	gtp-binding protein TYPA
HMPREF9154_0485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF9154_0486	COG1461	Dihydroxyacetone kinase
HMPREF9154_0487	COG2376	Dihydroxyacetone kinase
HMPREF9154_0488	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMPREF9154_0491	COG3189	MarR family transcriptional regulator
HMPREF9154_0497	COG0151	Belongs to the GarS family
HMPREF9154_0498	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF9154_0503	COG1668	transmembrane transport
HMPREF9154_0504	COG4152	abc transporter atp-binding protein
HMPREF9154_0505	COG2197	response regulator
HMPREF9154_0506	COG4585	Histidine kinase
HMPREF9154_0507	COG0577	efflux transmembrane transporter activity
HMPREF9154_0507	COG1136	(ABC) transporter
HMPREF9154_0509	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HMPREF9154_0512	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF9154_0513	COG0047	phosphoribosylformylglycinamidine synthase activity
HMPREF9154_0515	COG1051	belongs to the nudix hydrolase family
HMPREF9154_0517	COG0427	acetyl-CoA hydrolase
HMPREF9154_0520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF9154_0521	COG4115	mRNA cleavage
HMPREF9154_0522	COG2161	toxin-antitoxin pair type II binding
HMPREF9154_0525	COG4585	Histidine kinase
HMPREF9154_0527	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMPREF9154_0530	COG1331	Highly conserved protein containing a thioredoxin domain
HMPREF9154_0532	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_0533	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMPREF9154_0540	COG2814	Major facilitator Superfamily
HMPREF9154_0541	COG1309	transcriptional regulator
HMPREF9154_0546	COG0785	Cytochrome C biogenesis protein
HMPREF9154_0546	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF9154_0548	COG5002	protein histidine kinase activity
HMPREF9154_0550	COG0133	tryptophan synthase activity
HMPREF9154_0551	COG2233	PERMEase
HMPREF9154_0556	COG0084	hydrolase, TatD family'
HMPREF9154_0557	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HMPREF9154_0558	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HMPREF9154_0561	COG1136	(ABC) transporter
HMPREF9154_0561	COG0577	efflux transmembrane transporter activity
HMPREF9154_0564	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9154_0567	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMPREF9154_0568	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF9154_0571	COG0577	efflux transmembrane transporter activity
HMPREF9154_0571	COG1136	(ABC) transporter
HMPREF9154_0572	COG1136	(ABC) transporter
HMPREF9154_0572	COG0577	efflux transmembrane transporter activity
HMPREF9154_0574	COG1131	(ABC) transporter
HMPREF9154_0577	COG2094	Belongs to the DNA glycosylase MPG family
HMPREF9154_0579	COG0583	DNA-binding transcription factor activity
HMPREF9154_0583	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HMPREF9154_0584	COG0193	aminoacyl-tRNA hydrolase activity
HMPREF9154_0590	COG2304	oxidoreductase activity
HMPREF9154_0592	COG0148	phosphopyruvate hydratase activity
HMPREF9154_0597	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HMPREF9154_0597	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HMPREF9154_0598	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF9154_0600	COG3831	ATPase activity
HMPREF9154_0605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9154_0607	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF9154_0608	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMPREF9154_0609	COG2188	Transcriptional regulator
HMPREF9154_0611	COG0095	Lipoate-protein ligase
HMPREF9154_0614	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_0615	COG4191	Histidine kinase
HMPREF9154_0619	COG0765	amino acid transport
HMPREF9154_0625	COG1468	defense response to virus
HMPREF9154_0625	COG1518	maintenance of DNA repeat elements
HMPREF9154_0631	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF9154_0632	COG3591	Belongs to the peptidase S1B family
HMPREF9154_0643	COG1349	DNA-binding transcription factor activity
HMPREF9154_0644	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9154_0645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9154_0646	COG0022	dehydrogenase e1 component
HMPREF9154_0648	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_0653	COG2376	Dihydroxyacetone kinase
HMPREF9154_0654	COG1063	alcohol dehydrogenase
HMPREF9154_0657	COG1113	amino acid transport
HMPREF9154_0658	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HMPREF9154_0660	COG1472	Belongs to the glycosyl hydrolase 3 family
HMPREF9154_0662	COG0657	acetylesterase activity
HMPREF9154_0662	COG2755	lipolytic protein G-D-S-L family
HMPREF9154_0663	COG0823	Involved in the tonB-independent uptake of proteins
HMPREF9154_0663	COG1506	peptidase
HMPREF9154_0663	COG4946	Tricorn protease homolog
HMPREF9154_0675	COG0038	chloride channel
HMPREF9154_0676	COG0588	phosphoglycerate mutase activity
HMPREF9154_0677	COG0726	polysaccharide deacetylase
HMPREF9154_0678	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF9154_0679	COG5002	protein histidine kinase activity
HMPREF9154_0680	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_0681	COG1329	Transcriptional regulator
HMPREF9154_0683	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HMPREF9154_0688	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9154_0694	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HMPREF9154_0696	COG1132	(ABC) transporter
HMPREF9154_0696	COG2375	cellular response to nickel ion
HMPREF9154_0698	COG0789	Transcriptional regulator
HMPREF9154_0699	COG0698	ribose 5-phosphate isomerase
HMPREF9154_0701	COG0215	cysteine-tRNA ligase activity
HMPREF9154_0704	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_0705	COG2205	protein histidine kinase activity
HMPREF9154_0706	COG2132	Multicopper oxidase
HMPREF9154_0712	COG2226	methyltransferase
HMPREF9154_0714	COG3541	Predicted nucleotidyltransferase
HMPREF9154_0718	COG0626	cystathionine gamma-synthase activity
HMPREF9154_0719	COG3842	ATPase activity
HMPREF9154_0722	COG0275	rRNA processing
HMPREF9154_0727	COG0454	-acetyltransferase
HMPREF9154_0731	COG3142	Participates in the control of copper homeostasis
HMPREF9154_0732	COG0494	nUDIX hydrolase
HMPREF9154_0734	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF9154_0735	COG1278	Cold shock
HMPREF9154_0737	COG2252	PERMEase
HMPREF9154_0743	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HMPREF9154_0745	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HMPREF9154_0748	COG1321	iron dependent repressor
HMPREF9154_0749	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF9154_0751	COG0674	pyruvate-flavodoxin oxidoreductase activity
HMPREF9154_0751	COG1013	pyruvate-flavodoxin oxidoreductase activity
HMPREF9154_0751	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HMPREF9154_0751	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HMPREF9154_0755	COG0517	IMP dehydrogenase activity
HMPREF9154_0755	COG1125	glycine betaine transport
HMPREF9154_0757	COG1174	glycine betaine transport
HMPREF9154_0759	COG0477	Major facilitator Superfamily
HMPREF9154_0761	COG0156	8-amino-7-oxononanoate synthase activity
HMPREF9154_0763	COG0604	alcohol dehydrogenase
HMPREF9154_0768	COG3048	D-serine ammonia-lyase activity
HMPREF9154_0773	COG1304	FMN binding
HMPREF9154_0777	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_0778	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_0779	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMPREF9154_0780	COG1120	ATPase activity
HMPREF9154_0788	COG1140	nitrate reductase beta subunit
HMPREF9154_0794	COG0315	cyclic pyranopterin monophosphate synthase activity
HMPREF9154_0795	COG0746	molybdenum cofactor guanylyltransferase activity
HMPREF9154_0797	COG1609	Transcriptional regulator
HMPREF9154_0801	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_0812	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_0813	COG1120	ATPase activity
HMPREF9154_0821	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HMPREF9154_0823	COG0314	molybdopterin synthase activity
HMPREF9154_0838	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HMPREF9154_0840	COG2986	histidine ammonia-lyase
HMPREF9154_0842	COG0366	Alpha amylase catalytic
HMPREF9154_0848	COG1131	(ABC) transporter
HMPREF9154_0852	COG1846	Transcriptional regulator
HMPREF9154_0855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMPREF9154_0856	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HMPREF9154_0860	COG4721	ABC-type cobalt transport system, permease component
HMPREF9154_0861	COG3845	ABC transporter
HMPREF9154_0870	COG2190	(PTS) system
HMPREF9154_0870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9154_0870	COG1263	PTS System
HMPREF9154_0871	COG1404	Belongs to the peptidase S8 family
HMPREF9154_0873	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF9154_0873	COG0574	Belongs to the PEP-utilizing enzyme family
HMPREF9154_0874	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF9154_0874	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMPREF9154_0874	COG0351	phosphomethylpyrimidine kinase
HMPREF9154_0875	COG0351	phosphomethylpyrimidine kinase
HMPREF9154_0879	COG1404	Belongs to the peptidase S8 family
HMPREF9154_0888	COG0514	ATP-dependent DNA helicase (RecQ)
HMPREF9154_0889	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HMPREF9154_0890	COG0542	response to heat
HMPREF9154_0896	COG5012	cobalamin binding
HMPREF9154_0899	COG1113	amino acid transport
HMPREF9154_0900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9154_0901	COG0534	Mate efflux family protein
HMPREF9154_0906	COG0714	Associated with various cellular activities
HMPREF9154_0911	COG0515	serine threonine protein kinase
HMPREF9154_0911	COG2815	serine threonine protein kinase
HMPREF9154_0914	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMPREF9154_0915	COG1704	LemA family
HMPREF9154_0919	COG0191	fructose-bisphosphate aldolase activity
HMPREF9154_0921	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_0925	COG1070	Carbohydrate kinase
HMPREF9154_0931	COG1045	serine acetyltransferase
HMPREF9154_0932	COG4770	biotin carboxylase activity
HMPREF9154_0941	COG0424	maF-like protein
HMPREF9154_0943	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HMPREF9154_0949	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF9154_0951	COG1316	TRANSCRIPTIONal
HMPREF9154_0962	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9154_0963	COG2835	tetraacyldisaccharide 4'-kinase activity
HMPREF9154_0965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HMPREF9154_0973	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HMPREF9154_0974	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HMPREF9154_0975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HMPREF9154_0976	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMPREF9154_0977	COG0714	Associated with various cellular activities
HMPREF9154_0980	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HMPREF9154_0981	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HMPREF9154_0984	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF9154_0987	COG0156	8-amino-7-oxononanoate synthase activity
HMPREF9154_0988	COG1063	alcohol dehydrogenase
HMPREF9154_0990	COG0259	pyridoxamine-phosphate oxidase activity
HMPREF9154_0994	COG1739	Uncharacterized protein family UPF0029
HMPREF9154_1000	COG1053	succinate dehydrogenase
HMPREF9154_1002	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HMPREF9154_1006	COG0431	NADPH-dependent FMN reductase
HMPREF9154_1009	COG0246	Mannitol dehydrogenase
HMPREF9154_1012	COG0189	ligase activity
HMPREF9154_1014	COG1073	alpha beta
HMPREF9154_1019	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_1020	COG3321	synthase
HMPREF9154_1024	COG2070	2-Nitropropane dioxygenase
HMPREF9154_1024	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF9154_1025	COG1024	Enoyl-CoA hydratase
HMPREF9154_1027	COG4221	oxidoreductase activity
HMPREF9154_1027	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_1027	COG0300	oxidoreductase activity
HMPREF9154_1027	COG3321	synthase
HMPREF9154_1031	COG0604	alcohol dehydrogenase
HMPREF9154_1031	COG3321	synthase
HMPREF9154_1032	COG3425	synthase
HMPREF9154_1033	COG1024	Enoyl-CoA hydratase
HMPREF9154_1035	COG1131	(ABC) transporter
HMPREF9154_1044	COG0252	asparaginase activity
HMPREF9154_1051	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HMPREF9154_1055	COG1160	GTP binding
HMPREF9154_1057	COG0322	excinuclease ABC activity
HMPREF9154_1061	COG1268	BioY protein
HMPREF9154_1062	COG1122	ATPase activity
HMPREF9154_1064	COG1660	Displays ATPase and GTPase activities
HMPREF9154_1065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HMPREF9154_1067	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HMPREF9154_1068	COG0126	phosphoglycerate kinase activity
HMPREF9154_1069	COG0149	triose-phosphate isomerase activity
HMPREF9154_1070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPREF9154_1075	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF9154_1083	COG0396	ATPase activity
HMPREF9154_1084	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMPREF9154_1085	COG0822	iron-sulfur transferase activity
HMPREF9154_1087	COG2267	carboxylic ester hydrolase activity
HMPREF9154_1091	COG0488	(ABC) transporter
HMPREF9154_1092	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9154_1096	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_1098	COG1119	ATPase activity
HMPREF9154_1099	COG0114	fumarate hydratase activity
HMPREF9154_1106	COG0242	peptide deformylase activity
HMPREF9154_1107	COG4974	Belongs to the 'phage' integrase family
HMPREF9154_1108	COG1196	nuclear chromosome segregation
HMPREF9154_1108	COG0739	heme binding
HMPREF9154_1108	COG0741	lytic transglycosylase activity
HMPREF9154_1109	COG0052	Belongs to the universal ribosomal protein uS2 family
HMPREF9154_1110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMPREF9154_1111	COG0528	UMP kinase activity
HMPREF9154_1112	COG0233	cytoplasmic translational termination
HMPREF9154_1113	COG0575	Belongs to the CDS family
HMPREF9154_1114	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HMPREF9154_1115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMPREF9154_1116	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HMPREF9154_1117	COG0750	zinc metalloprotease
HMPREF9154_1120	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HMPREF9154_1121	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HMPREF9154_1122	COG1492	cobalamin metabolic process
HMPREF9154_1125	COG1253	flavin adenine dinucleotide binding
HMPREF9154_1127	COG1744	ABC transporter substrate-binding protein PnrA-like
HMPREF9154_1128	COG3845	ABC transporter
HMPREF9154_1129	COG4603	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_1130	COG1079	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_1132	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HMPREF9154_1133	COG0328	RNA-DNA hybrid ribonuclease activity
HMPREF9154_1135	COG0823	Involved in the tonB-independent uptake of proteins
HMPREF9154_1135	COG1506	peptidase
HMPREF9154_1135	COG4946	Tricorn protease homolog
HMPREF9154_1136	COG1131	(ABC) transporter
HMPREF9154_1138	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF9154_1141	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9154_1144	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF9154_1146	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HMPREF9154_1151	COG0714	Associated with various cellular activities
HMPREF9154_1153	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HMPREF9154_1160	COG1342	Belongs to the UPF0251 family
HMPREF9154_1162	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HMPREF9154_1165	COG0616	signal peptide processing
HMPREF9154_1173	COG2171	N-acyltransferase activity
HMPREF9154_1174	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF9154_1178	COG0297	glycogen (starch) synthase activity
HMPREF9154_1179	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF9154_1182	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF9154_1183	COG1595	DNA-templated transcription, initiation
HMPREF9154_1185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMPREF9154_1192	COG0006	proline dipeptidase activity
HMPREF9154_1194	COG0557	exoribonuclease II activity
HMPREF9154_1209	COG0174	glutamine synthetase
HMPREF9154_1211	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HMPREF9154_1213	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF9154_1214	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMPREF9154_1215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF9154_1216	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9154_1218	COG1349	DNA-binding transcription factor activity
HMPREF9154_1219	COG1063	alcohol dehydrogenase
HMPREF9154_1222	COG2409	Drug exporters of the RND superfamily
HMPREF9154_1223	COG0174	glutamine synthetase
HMPREF9154_1224	COG1131	(ABC) transporter
HMPREF9154_1226	COG1476	TRANSCRIPTIONal
HMPREF9154_1227	COG1309	transcriptional regulator
HMPREF9154_1236	COG2188	Transcriptional regulator
HMPREF9154_1237	COG0488	(ABC) transporter
HMPREF9154_1239	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HMPREF9154_1240	COG0321	lipoyl(octanoyl) transferase activity
HMPREF9154_1243	COG0310	cobalt ion transport
HMPREF9154_1255	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HMPREF9154_1256	COG1797	cobyrinic acid a,c-diamide synthase activity
HMPREF9154_1257	COG1648	precorrin-2 dehydrogenase activity
HMPREF9154_1257	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HMPREF9154_1260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HMPREF9154_1261	COG0456	acetyltransferase
HMPREF9154_1262	COG0442	prolyl-tRNA aminoacylation
HMPREF9154_1264	COG0779	Required for maturation of 30S ribosomal subunits
HMPREF9154_1265	COG0195	Participates in both transcription termination and antitermination
HMPREF9154_1268	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMPREF9154_1269	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMPREF9154_1270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMPREF9154_1271	COG2186	Transcriptional regulator
HMPREF9154_1272	COG4139	cobalamin transport
HMPREF9154_1275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HMPREF9154_1276	COG4106	trans-aconitate 2-methyltransferase activity
HMPREF9154_1277	COG1620	l-lactate permease
HMPREF9154_1278	COG0247	lactate metabolic process
HMPREF9154_1279	COG1139	Iron-sulfur cluster binding protein
HMPREF9154_1280	COG1556	Lactate utilization protein
HMPREF9154_1282	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMPREF9154_1283	COG1185	polyribonucleotide nucleotidyltransferase activity
HMPREF9154_1284	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HMPREF9154_1285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMPREF9154_1287	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF9154_1290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMPREF9154_1291	COG1124	(ABC) transporter
HMPREF9154_1292	COG4172	Belongs to the ABC transporter superfamily
HMPREF9154_1293	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_1294	COG0601	transmembrane transport
HMPREF9154_1296	COG0003	Pfam Anion-transporting ATPase
HMPREF9154_1298	COG0003	Pfam Anion-transporting ATPase
HMPREF9154_1299	COG1846	Transcriptional regulator
HMPREF9154_1301	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HMPREF9154_1302	COG0571	ribonuclease III activity
HMPREF9154_1303	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HMPREF9154_1305	COG1196	nuclear chromosome segregation
HMPREF9154_1308	COG0640	Transcriptional regulator
HMPREF9154_1310	COG2197	response regulator
HMPREF9154_1312	COG4585	Histidine kinase
HMPREF9154_1315	COG0616	signal peptide processing
HMPREF9154_1317	COG0228	four-way junction DNA binding
HMPREF9154_1318	COG1837	Belongs to the UPF0109 family
HMPREF9154_1319	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMPREF9154_1320	COG0336	Belongs to the RNA methyltransferase TrmD family
HMPREF9154_1322	COG1053	succinate dehydrogenase
HMPREF9154_1323	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HMPREF9154_1324	COG0335	large ribosomal subunit rRNA binding
HMPREF9154_1326	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMPREF9154_1328	COG0792	nuclease activity
HMPREF9154_1334	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HMPREF9154_1336	COG0440	acetolactate synthase activity
HMPREF9154_1337	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HMPREF9154_1338	COG0477	Major facilitator Superfamily
HMPREF9154_1339	COG1061	Type III restriction enzyme res subunit
HMPREF9154_1342	COG0473	3-isopropylmalate dehydrogenase activity
HMPREF9154_1343	COG0179	Fumarylacetoacetate (FAA) hydrolase
HMPREF9154_1348	COG2197	response regulator
HMPREF9154_1350	COG1131	(ABC) transporter
HMPREF9154_1353	COG1414	Transcriptional regulator
HMPREF9154_1354	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMPREF9154_1355	COG0066	3-isopropylmalate dehydratase activity
HMPREF9154_1358	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_1359	COG1120	ATPase activity
HMPREF9154_1362	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF9154_1364	COG3585	molybdate ion transport
HMPREF9154_1366	COG1674	ftsk spoiiie
HMPREF9154_1367	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF9154_1372	COG2137	regulation of response to DNA damage stimulus
HMPREF9154_1373	COG1418	mRNA catabolic process
HMPREF9154_1374	COG2017	converts alpha-aldose to the beta-anomer
HMPREF9154_1375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF9154_1377	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMPREF9154_1378	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HMPREF9154_1379	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF9154_1385	COG0747	negative chemotaxis
HMPREF9154_1387	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_1390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPREF9154_1391	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF9154_1392	COG1162	GTPase activity
HMPREF9154_1393	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HMPREF9154_1395	COG1595	DNA-templated transcription, initiation
HMPREF9154_1399	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF9154_1400	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9154_1400	COG0567	Dehydrogenase, E1 component
HMPREF9154_1405	COG0460	homoserine dehydrogenase
HMPREF9154_1406	COG0083	homoserine kinase activity
HMPREF9154_1408	COG0254	rRNA binding
HMPREF9154_1409	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMPREF9154_1410	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF9154_1412	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF9154_1415	COG0356	it plays a direct role in the translocation of protons across the membrane
HMPREF9154_1416	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF9154_1417	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HMPREF9154_1418	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF9154_1419	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMPREF9154_1420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMPREF9154_1421	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HMPREF9154_1422	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HMPREF9154_1425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMPREF9154_1426	COG0596	Alpha beta hydrolase
HMPREF9154_1436	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF9154_1437	COG1381	Involved in DNA repair and RecF pathway recombination
HMPREF9154_1439	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9154_1440	COG1120	ATPase activity
HMPREF9154_1441	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF9154_1444	COG1175	transmembrane transport
HMPREF9154_1447	COG1940	carbohydrate kinase activity
HMPREF9154_1448	COG0339	signal peptide processing
HMPREF9154_1452	COG1136	(ABC) transporter
HMPREF9154_1453	COG3851	Histidine kinase
HMPREF9154_1454	COG2197	response regulator
HMPREF9154_1455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HMPREF9154_1456	COG1131	(ABC) transporter
HMPREF9154_1458	COG4585	Histidine kinase
HMPREF9154_1459	COG2197	response regulator
HMPREF9154_1462	COG0406	alpha-ribazole phosphatase activity
HMPREF9154_1479	COG0714	Associated with various cellular activities
HMPREF9154_1481	COG2304	oxidoreductase activity
HMPREF9154_1482	COG2304	oxidoreductase activity
HMPREF9154_1486	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_1487	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMPREF9154_1490	COG1653	transport
HMPREF9154_1491	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HMPREF9154_1493	COG0205	6-phosphofructokinase activity
HMPREF9154_1497	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF9154_1498	COG2884	Cell division ATP-binding protein ftsE
HMPREF9154_1501	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMPREF9154_1504	COG0366	Alpha amylase catalytic
HMPREF9154_1505	COG1678	Uncharacterized ACR, COG1678
HMPREF9154_1506	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_1507	COG5002	protein histidine kinase activity
HMPREF9154_1508	COG5401	PFAM Sporulation and spore germination
HMPREF9154_1510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMPREF9154_1511	COG0653	protein targeting
HMPREF9154_1515	COG0613	PHP domain protein
HMPREF9154_1516	COG0180	Tryptophanyl-tRNA synthetase
HMPREF9154_1517	COG0513	Belongs to the DEAD box helicase family
HMPREF9154_1520	COG1278	Cold shock
HMPREF9154_1524	COG0187	DNA topoisomerase II activity
HMPREF9154_1527	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9154_1532	COG1435	thymidine kinase activity
HMPREF9154_1536	COG0756	dUTP diphosphatase activity
HMPREF9154_1540	COG0569	domain protein
HMPREF9154_1541	COG0531	amino acid
HMPREF9154_1542	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF9154_1543	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HMPREF9154_1545	COG0686	Belongs to the AlaDH PNT family
HMPREF9154_1546	COG1113	amino acid transport
HMPREF9154_1548	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF9154_1551	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF9154_1559	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMPREF9154_1565	COG1716	ATPase activity
HMPREF9154_1569	COG1295	ribonuclease BN
HMPREF9154_1573	COG0009	L-threonylcarbamoyladenylate synthase
HMPREF9154_1575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF9154_1579	COG1937	Protein conserved in bacteria
HMPREF9154_1581	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF9154_1582	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HMPREF9154_1585	COG3030	protein affecting phage T7 exclusion by the F plasmid
HMPREF9154_1586	COG1216	Glycosyl transferase, family 2
HMPREF9154_1587	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HMPREF9154_1588	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMPREF9154_1588	COG2813	Specifically methylates the guanine in position
HMPREF9154_1589	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMPREF9154_1591	COG2212	antiporter activity
HMPREF9154_1592	COG1863	multisubunit Na H antiporter MnhE subunit
HMPREF9154_1593	COG0651	ATP synthesis coupled electron transport
HMPREF9154_1594	COG1006	Multisubunit Na H antiporter MnhC subunit
HMPREF9154_1595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HMPREF9154_1595	COG2111	Na H antiporter
HMPREF9154_1596	COG1376	ErfK ybiS ycfS ynhG family protein
HMPREF9154_1599	COG0702	epimerase
HMPREF9154_1601	COG1160	GTP binding
HMPREF9154_1602	COG0488	(ABC) transporter
HMPREF9154_1604	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HMPREF9154_1608	COG0646	methionine synthase
HMPREF9154_1608	COG1410	methionine synthase
HMPREF9154_1614	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF9154_1616	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMPREF9154_1618	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMPREF9154_1619	COG1758	RNA polymerase activity
HMPREF9154_1620	COG0194	GDP metabolic process
HMPREF9154_1622	COG0284	orotidine-5'-phosphate decarboxylase activity
HMPREF9154_1623	COG0167	dihydroorotate dehydrogenase activity
HMPREF9154_1624	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HMPREF9154_1625	COG0505	Belongs to the CarA family
HMPREF9154_1626	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF9154_1627	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMPREF9154_1628	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMPREF9154_1629	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMPREF9154_1630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMPREF9154_1631	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF9154_1632	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMPREF9154_1633	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMPREF9154_1634	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMPREF9154_1638	COG2814	Major facilitator Superfamily
HMPREF9154_1640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HMPREF9154_1641	COG0124	histidyl-tRNA synthetase
HMPREF9154_1643	COG1196	nuclear chromosome segregation
HMPREF9154_1645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMPREF9154_1647	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF9154_1648	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPREF9154_1649	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPREF9154_1650	COG1862	Preprotein translocase
HMPREF9154_1651	COG2255	four-way junction helicase activity
HMPREF9154_1652	COG0632	four-way junction helicase activity
HMPREF9154_1653	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HMPREF9154_1654	COG0217	transcriptional regulatory protein
HMPREF9154_1655	COG0456	acetyltransferase
HMPREF9154_1659	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HMPREF9154_1660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMPREF9154_1661	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HMPREF9154_1662	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMPREF9154_1663	COG0131	Imidazoleglycerol-phosphate dehydratase
HMPREF9154_1664	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMPREF9154_1665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HMPREF9154_1668	COG0587	DNA-directed DNA polymerase activity
HMPREF9154_1670	COG2197	response regulator
HMPREF9154_1671	COG0577	efflux transmembrane transporter activity
HMPREF9154_1671	COG1136	(ABC) transporter
HMPREF9154_1674	COG3842	ATPase activity
HMPREF9154_1677	COG1653	transport
HMPREF9154_1678	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_1680	COG0159	tryptophan synthase activity
HMPREF9154_1681	COG0133	tryptophan synthase activity
HMPREF9154_1682	COG0134	indole-3-glycerol-phosphate synthase activity
HMPREF9154_1683	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF9154_1684	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HMPREF9154_1687	COG1690	Belongs to the RtcB family
HMPREF9154_1689	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF9154_1690	COG0154	amidase activity
HMPREF9154_1691	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF9154_1696	COG4585	Histidine kinase
HMPREF9154_1697	COG2197	response regulator
HMPREF9154_1702	COG0482	sulfurtransferase activity
HMPREF9154_1706	COG0366	Alpha amylase catalytic
HMPREF9154_1707	COG3281	Trehalose synthase
HMPREF9154_1708	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMPREF9154_1715	COG1408	metallophosphoesterase
HMPREF9154_1716	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HMPREF9154_1717	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMPREF9154_1719	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMPREF9154_1723	COG1609	Transcriptional regulator
HMPREF9154_1727	COG0343	queuine tRNA-ribosyltransferase activity
HMPREF9154_1730	COG0484	heat shock protein binding
HMPREF9154_1731	COG1420	regulation of RNA biosynthetic process
HMPREF9154_1733	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF9154_1736	COG1131	(ABC) transporter
HMPREF9154_1738	COG4221	oxidoreductase activity
HMPREF9154_1743	COG2318	DinB family
HMPREF9154_1746	COG1175	transmembrane transport
HMPREF9154_1749	COG0481	GTPase activity
HMPREF9154_1750	COG0268	Binds directly to 16S ribosomal RNA
HMPREF9154_1751	COG4868	Belongs to the UPF0371 family
HMPREF9154_1757	COG3851	Histidine kinase
HMPREF9154_1758	COG2197	response regulator
HMPREF9154_1759	COG0277	FAD linked oxidase domain protein
HMPREF9154_1768	COG0640	Transcriptional regulator
HMPREF9154_1769	COG2814	Major facilitator Superfamily
HMPREF9154_1774	COG1131	(ABC) transporter
HMPREF9154_1779	COG1760	l-serine dehydratase
HMPREF9154_1780	COG2855	membrane
HMPREF9154_1781	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HMPREF9154_1783	COG0456	acetyltransferase
HMPREF9154_1783	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF9154_1797	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HMPREF9154_1798	COG0113	porphobilinogen synthase activity
HMPREF9154_1799	COG0181	hydroxymethylbilane synthase activity
HMPREF9154_1800	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HMPREF9154_1801	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HMPREF9154_1802	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HMPREF9154_1803	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HMPREF9154_1804	COG3253	May function as heme-dependent peroxidase
HMPREF9154_1804	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HMPREF9154_1809	COG0656	L-ascorbic acid biosynthetic process
HMPREF9154_1814	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF9154_1818	COG0799	negative regulation of ribosome biogenesis
HMPREF9154_1819	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF9154_1821	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMPREF9154_1822	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMPREF9154_1823	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMPREF9154_1824	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HMPREF9154_1825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HMPREF9154_1827	COG1530	ribonuclease E activity
HMPREF9154_1827	COG1530	ribonuclease E activity
HMPREF9154_1830	COG0285	dihydrofolate synthase activity
HMPREF9154_1833	COG0525	valine-tRNA ligase activity
HMPREF9154_1834	COG4946	Tricorn protease homolog
HMPREF9154_1834	COG0793	Belongs to the peptidase S41A family
HMPREF9154_1835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HMPREF9154_1836	COG0740	serine-type endopeptidase activity
HMPREF9154_1837	COG0740	serine-type endopeptidase activity
HMPREF9154_1839	COG0544	peptidyl-prolyl cis-trans isomerase activity
HMPREF9154_1840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF9154_1844	COG1950	PFAM Membrane protein of
HMPREF9154_1848	COG0586	Pfam SNARE associated Golgi protein
HMPREF9154_1849	COG1349	DNA-binding transcription factor activity
HMPREF9154_1850	COG0698	ribose 5-phosphate isomerase
HMPREF9154_1852	COG0647	UMP catabolic process
HMPREF9154_1853	COG1070	Carbohydrate kinase
HMPREF9154_1854	COG0371	Dehydrogenase
HMPREF9154_1861	COG0701	Predicted permease
HMPREF9154_1867	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF9154_1868	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMPREF9154_1870	COG0540	Belongs to the ATCase OTCase family
HMPREF9154_1871	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF9154_1873	COG0477	Major facilitator Superfamily
HMPREF9154_1876	COG1201	RNA secondary structure unwinding
HMPREF9154_1879	COG0583	DNA-binding transcription factor activity
HMPREF9154_1881	COG1022	Amp-dependent synthetase and ligase
HMPREF9154_1883	COG0277	FAD linked oxidase domain protein
HMPREF9154_1891	COG2197	response regulator
HMPREF9154_1892	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMPREF9154_1896	COG0556	nucleotide-excision repair
HMPREF9154_1897	COG0237	dephospho-CoA kinase activity
HMPREF9154_1901	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HMPREF9154_1902	COG0509	glycine decarboxylation via glycine cleavage system
HMPREF9154_1903	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMPREF9154_1903	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMPREF9154_1904	COG0539	negative regulation of cytoplasmic translation
HMPREF9154_1907	COG2050	protein possibly involved in aromatic compounds catabolism
HMPREF9154_1910	COG0469	pyruvate kinase activity
HMPREF9154_1912	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMPREF9154_1916	COG1799	cell septum assembly
HMPREF9154_1919	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HMPREF9154_1920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMPREF9154_1921	COG0772	Belongs to the SEDS family
HMPREF9154_1922	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMPREF9154_1923	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF9154_1924	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF9154_1925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMPREF9154_1928	COG0275	rRNA processing
HMPREF9154_1929	COG2001	Belongs to the MraZ family
HMPREF9154_1930	COG0714	Associated with various cellular activities
HMPREF9154_1936	COG1615	UPF0182 protein
HMPREF9154_1938	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HMPREF9154_1946	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF9154_1948	COG1946	Acyl-CoA thioesterase
HMPREF9154_1949	COG1643	Atp-dependent helicase
HMPREF9154_1953	COG0129	dihydroxy-acid dehydratase activity
HMPREF9154_1955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HMPREF9154_1956	COG1333	cytochrome c biogenesis protein
HMPREF9154_1959	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HMPREF9154_1962	COG0710	3-dehydroquinate dehydratase activity
HMPREF9154_1963	COG1309	transcriptional regulator
HMPREF9154_1964	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF9154_1966	COG0028	Belongs to the TPP enzyme family
HMPREF9154_1968	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF9154_1970	COG0477	Major facilitator Superfamily
HMPREF9154_1971	COG1053	succinate dehydrogenase
HMPREF9154_1986	COG2337	Toxic component of a toxin-antitoxin (TA) module
HMPREF9154_1987	COG3609	addiction module antidote protein, CC2985 family
HMPREF9154_1988	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF9154_1989	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF9154_1991	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMPREF9154_1992	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF9154_1993	COG0107	imidazoleglycerol-phosphate synthase activity
HMPREF9154_1994	COG4581	dead DEAH box helicase
HMPREF9154_1996	COG0805	protein transport
HMPREF9154_1997	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMPREF9154_2001	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF9154_2004	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMPREF9154_2009	COG0494	nUDIX hydrolase
HMPREF9154_2013	COG1335	isochorismatase
HMPREF9154_2014	COG0497	DNA recombination
HMPREF9154_2015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMPREF9154_2018	COG0647	UMP catabolic process
HMPREF9154_2023	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMPREF9154_2026	COG0165	Argininosuccinate lyase
HMPREF9154_2028	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HMPREF9154_2029	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HMPREF9154_2030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HMPREF9154_2031	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HMPREF9154_2032	COG0495	leucyl-tRNA aminoacylation
HMPREF9154_2034	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMPREF9154_2036	COG0072	phenylalanine-tRNA ligase activity
HMPREF9154_2036	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF9154_2037	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMPREF9154_2040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMPREF9154_2041	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HMPREF9154_2042	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMPREF9154_2044	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2045	COG1120	ATPase activity
HMPREF9154_2049	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HMPREF9154_2050	COG0140	phosphoribosyl-ATP diphosphatase activity
HMPREF9154_2051	COG0215	cysteine-tRNA ligase activity
HMPREF9154_2053	COG0667	Aldo Keto reductase
HMPREF9154_2056	COG0477	Major facilitator Superfamily
HMPREF9154_2059	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HMPREF9154_2059	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HMPREF9154_2060	COG3973	AAA domain
HMPREF9154_2062	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9154_2063	COG0142	geranyltranstransferase activity
HMPREF9154_2066	COG1120	ATPase activity
HMPREF9154_2067	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2068	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2069	COG4592	Periplasmic binding protein
HMPREF9154_2071	COG0515	serine threonine protein kinase
HMPREF9154_2071	COG2815	serine threonine protein kinase
HMPREF9154_2075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HMPREF9154_2076	COG2197	response regulator
HMPREF9154_2081	COG0088	Forms part of the polypeptide exit tunnel
HMPREF9154_2083	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMPREF9154_2092	COG0010	Belongs to the arginase family
HMPREF9154_2096	COG4988	ABC transporter
HMPREF9154_2097	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HMPREF9154_2102	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9154_2104	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9154_2106	COG0039	L-malate dehydrogenase activity
HMPREF9154_2108	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMPREF9154_2109	COG0138	bifunctional purine biosynthesis protein purh
HMPREF9154_2111	COG0535	radical SAM domain protein
HMPREF9154_2117	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMPREF9154_2119	COG2197	response regulator
HMPREF9154_2120	COG2205	protein histidine kinase activity
HMPREF9154_2123	COG1983	PspC domain protein
HMPREF9154_2127	COG1129	ABC transporter
HMPREF9154_2128	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HMPREF9154_2130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HMPREF9154_2130	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9154_2134	COG3226	Transcriptional regulator
HMPREF9154_2136	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9154_2138	COG1120	ATPase activity
HMPREF9154_2139	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2144	COG0516	GMP reductase activity
HMPREF9154_2146	COG2860	membrane
HMPREF9154_2147	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF9154_2149	COG1486	melibiose metabolic process
HMPREF9154_2152	COG0459	protein refolding
HMPREF9154_2153	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMPREF9154_2158	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_2159	COG0601	transmembrane transport
HMPREF9154_2161	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMPREF9154_2163	COG0456	acetyltransferase
HMPREF9154_2163	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF9154_2164	COG0802	atpase or kinase
HMPREF9154_2173	COG0736	holo-[acyl-carrier-protein] synthase activity
HMPREF9154_2174	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HMPREF9154_2175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HMPREF9154_2175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMPREF9154_2176	COG1072	(Pantothenic acid kinase))
HMPREF9154_2177	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9154_2178	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HMPREF9154_2179	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMPREF9154_2181	COG2169	Transcriptional regulator
HMPREF9154_2181	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMPREF9154_2184	COG3304	Inner membrane component domain
HMPREF9154_2185	COG1120	ATPase activity
HMPREF9154_2186	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2188	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HMPREF9154_2189	COG0101	tRNA pseudouridine synthase activity
HMPREF9154_2194	COG0601	transmembrane transport
HMPREF9154_2195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_2196	COG0444	Belongs to the ABC transporter superfamily
HMPREF9154_2219	COG1674	ftsk spoiiie
HMPREF9154_2224	COG0203	ribosomal protein L17
HMPREF9154_2225	COG0202	RNA polymerase activity
HMPREF9154_2226	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMPREF9154_2227	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMPREF9154_2228	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMPREF9154_2229	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HMPREF9154_2230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMPREF9154_2234	COG0024	Methionine aminopeptidase
HMPREF9154_2235	COG0563	adenylate kinase activity
HMPREF9154_2236	COG0201	protein transport
HMPREF9154_2237	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HMPREF9154_2239	COG1841	ribosomal large subunit assembly
HMPREF9154_2240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMPREF9154_2241	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMPREF9154_2242	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HMPREF9154_2243	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMPREF9154_2244	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMPREF9154_2245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMPREF9154_2246	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HMPREF9154_2247	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMPREF9154_2252	COG3883	PFAM NLP P60 protein
HMPREF9154_2252	COG0791	NLP P60 protein
HMPREF9154_2262	COG1528	Iron-storage protein
HMPREF9154_2265	COG0784	Response regulator, receiver
HMPREF9154_2265	COG2205	protein histidine kinase activity
HMPREF9154_2265	COG2198	Histidine kinase
HMPREF9154_2267	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMPREF9154_2268	COG0255	Belongs to the universal ribosomal protein uL29 family
HMPREF9154_2269	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMPREF9154_2270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HMPREF9154_2271	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HMPREF9154_2272	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMPREF9154_2273	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMPREF9154_2274	COG0089	rRNA binding
HMPREF9154_2275	COG0088	Forms part of the polypeptide exit tunnel
HMPREF9154_2276	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMPREF9154_2277	COG0051	transcription antitermination factor activity, RNA binding
HMPREF9154_2280	COG1136	(ABC) transporter
HMPREF9154_2282	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF9154_2284	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF9154_2286	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMPREF9154_2287	COG0698	ribose 5-phosphate isomerase
HMPREF9154_2289	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMPREF9154_2290	COG0049	tRNA binding
HMPREF9154_2291	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMPREF9154_2292	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMPREF9154_2293	COG0085	RNA polymerase activity
HMPREF9154_2295	COG0222	ribosome binding
HMPREF9154_2296	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMPREF9154_2297	COG1132	(ABC) transporter
HMPREF9154_2302	COG2378	regulation of single-species biofilm formation
HMPREF9154_2305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF9154_2306	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF9154_2307	COG0254	rRNA binding
HMPREF9154_2310	COG0081	regulation of translation
HMPREF9154_2311	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMPREF9154_2312	COG0250	Participates in transcription elongation, termination and antitermination
HMPREF9154_2315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HMPREF9154_2317	COG2030	dehydratase
HMPREF9154_2318	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF9154_2324	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HMPREF9154_2325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9154_2325	COG3711	transcriptional antiterminator
HMPREF9154_2328	COG3732	PTS system glucitol sorbitol-specific
HMPREF9154_2330	COG0371	Dehydrogenase
HMPREF9154_2333	COG1131	(ABC) transporter
HMPREF9154_2339	COG0737	Belongs to the 5'-nucleotidase family
HMPREF9154_2341	COG2197	response regulator
HMPREF9154_2342	COG4585	Histidine kinase
HMPREF9154_2347	COG4585	Histidine kinase
HMPREF9154_2353	COG0577	efflux transmembrane transporter activity
HMPREF9154_2353	COG1136	(ABC) transporter
HMPREF9154_2357	COG0359	binds to the 23S rRNA
HMPREF9154_2358	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMPREF9154_2360	COG0360	Binds together with S18 to 16S ribosomal RNA
HMPREF9154_2363	COG1136	(ABC) transporter
HMPREF9154_2363	COG0577	efflux transmembrane transporter activity
HMPREF9154_2365	COG0778	Nitroreductase
HMPREF9154_2369	COG1022	Amp-dependent synthetase and ligase
HMPREF9154_2371	COG0789	Transcriptional regulator
HMPREF9154_2372	COG2190	(PTS) system
HMPREF9154_2372	COG2211	Major facilitator Superfamily
HMPREF9154_2373	COG0813	purine-nucleoside phosphorylase activity
HMPREF9154_2376	COG1666	GTP binding
HMPREF9154_2377	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HMPREF9154_2377	COG4106	trans-aconitate 2-methyltransferase activity
HMPREF9154_2379	COG2354	Protein conserved in bacteria
HMPREF9154_2380	COG0708	Exodeoxyribonuclease III
HMPREF9154_2382	COG0674	pyruvate-flavodoxin oxidoreductase activity
HMPREF9154_2382	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HMPREF9154_2383	COG1013	pyruvate-flavodoxin oxidoreductase activity
HMPREF9154_2388	COG0714	Associated with various cellular activities
HMPREF9154_2389	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HMPREF9154_2395	COG0142	geranyltranstransferase activity
HMPREF9154_2396	COG1007	ATP synthesis coupled electron transport
HMPREF9154_2399	COG0713	ATP synthesis coupled electron transport
HMPREF9154_2400	COG0839	Belongs to the complex I subunit 6 family
HMPREF9154_2401	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF9154_2402	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HMPREF9154_2403	COG1034	ATP synthesis coupled electron transport
HMPREF9154_2404	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HMPREF9154_2406	COG0649	NAD binding
HMPREF9154_2407	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF9154_2408	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF9154_2411	COG1169	isochorismate synthase
HMPREF9154_2415	COG4133	protoheme IX ABC transporter activity
HMPREF9154_2417	COG2226	methyltransferase
HMPREF9154_2419	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HMPREF9154_2420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HMPREF9154_2422	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HMPREF9154_2423	COG4948	Mandelate Racemase Muconate Lactonizing
HMPREF9154_2427	COG1461	Dihydroxyacetone kinase
HMPREF9154_2429	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF9154_2433	COG1132	(ABC) transporter
HMPREF9154_2433	COG2375	cellular response to nickel ion
HMPREF9154_2434	COG1132	(ABC) transporter
HMPREF9154_2435	COG4166	transmembrane transport
HMPREF9154_2447	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMPREF9154_2448	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF9154_2459	COG0604	alcohol dehydrogenase
HMPREF9154_2459	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_2459	COG3321	synthase
HMPREF9154_2460	COG1733	regulation of RNA biosynthetic process
HMPREF9154_2461	COG2197	response regulator
HMPREF9154_2462	COG4585	Histidine kinase
HMPREF9154_2463	COG1131	(ABC) transporter
HMPREF9154_2466	COG0667	Aldo Keto reductase
HMPREF9154_2471	COG2409	Drug exporters of the RND superfamily
HMPREF9154_2483	COG4585	Histidine kinase
HMPREF9154_2484	COG2197	response regulator
HMPREF9154_2486	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMPREF9154_2487	COG1136	(ABC) transporter
HMPREF9154_2488	COG1136	(ABC) transporter
HMPREF9154_2488	COG0577	efflux transmembrane transporter activity
HMPREF9154_2492	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HMPREF9154_2493	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMPREF9154_2497	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMPREF9154_2501	COG2056	Na+-H+ antiporter family
HMPREF9154_2502	COG0076	glutamate decarboxylase activity
HMPREF9154_2510	COG0840	transmembrane signaling receptor activity
HMPREF9154_2514	COG2814	Major facilitator Superfamily
HMPREF9154_2518	COG0454	-acetyltransferase
HMPREF9154_2518	COG0456	acetyltransferase
HMPREF9154_2520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPREF9154_2521	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF9154_2522	COG3830	Belongs to the UPF0237 family
HMPREF9154_2522	COG0560	Phosphoserine phosphatase
HMPREF9154_2527	COG1473	amidohydrolase
HMPREF9154_2529	COG1464	Belongs to the NlpA lipoprotein family
HMPREF9154_2530	COG2011	ABC-type metal ion transport system permease component
HMPREF9154_2531	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF9154_2541	COG0166	Belongs to the GPI family
HMPREF9154_2552	COG2838	Isocitrate dehydrogenase
HMPREF9154_2553	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HMPREF9154_2556	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF9154_2557	COG3833	ABC-type maltose transport systems, permease component
HMPREF9154_2558	COG1175	transmembrane transport
HMPREF9154_2561	COG0366	Alpha amylase catalytic
HMPREF9154_2562	COG0789	Transcriptional regulator
HMPREF9154_2563	COG0484	heat shock protein binding
HMPREF9154_2564	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMPREF9154_2596	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMPREF9154_2600	COG1970	mechanosensitive ion channel activity
HMPREF9154_2607	COG3226	Transcriptional regulator
HMPREF9154_2610	COG0281	malic enzyme
HMPREF9154_2615	COG0477	Major facilitator Superfamily
HMPREF9154_2617	COG0174	glutamine synthetase
HMPREF9154_2627	COG1234	tRNA 3'-trailer cleavage
HMPREF9154_2636	COG1309	transcriptional regulator
HMPREF9154_2637	COG0477	Major facilitator Superfamily
HMPREF9154_2646	COG4691	Plasmid stability protein
HMPREF9154_2648	COG4115	mRNA cleavage
HMPREF9154_2649	COG2161	toxin-antitoxin pair type II binding
HMPREF9154_2650	COG3226	Transcriptional regulator
HMPREF9154_2653	COG1733	regulation of RNA biosynthetic process
HMPREF9154_2660	COG0456	acetyltransferase
HMPREF9154_2665	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HMPREF9154_2666	COG1396	sequence-specific DNA binding
HMPREF9154_2671	COG0012	GTP binding
HMPREF9154_2672	COG1362	aminopeptidase activity
HMPREF9154_2673	COG1322	Protein conserved in bacteria
HMPREF9154_2674	COG0813	purine-nucleoside phosphorylase activity
HMPREF9154_2680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HMPREF9154_2683	COG1570	exodeoxyribonuclease VII activity
HMPREF9154_2684	COG1722	exodeoxyribonuclease VII activity
HMPREF9154_2688	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF9154_2690	COG1774	PSP1 C-terminal conserved region
HMPREF9154_2694	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF9154_2696	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMPREF9154_2701	COG1754	DNA topoisomerase type I activity
HMPREF9154_2701	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF9154_2711	COG1940	carbohydrate kinase activity
HMPREF9154_2712	COG1968	undecaprenyl-diphosphatase activity
HMPREF9154_2713	COG0385	Bile acid
HMPREF9154_2715	COG1621	beta-fructofuranosidase activity
HMPREF9154_2716	COG1136	(ABC) transporter
HMPREF9154_2719	COG0018	arginyl-trna synthetase
HMPREF9154_2720	COG0656	L-ascorbic acid biosynthetic process
HMPREF9154_2721	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMPREF9154_2723	COG1216	Glycosyl transferase, family 2
HMPREF9154_2730	COG1716	ATPase activity
HMPREF9154_2734	COG0768	penicillin binding
HMPREF9154_2735	COG0515	serine threonine protein kinase
HMPREF9154_2740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9154_2741	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF9154_2751	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMPREF9154_2752	COG1468	defense response to virus
HMPREF9154_2752	COG1518	maintenance of DNA repeat elements
HMPREF9154_2767	COG3263	regulation of cellular component size
HMPREF9154_2774	COG0438	transferase activity, transferring glycosyl groups
HMPREF9154_2775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_2781	COG2027	D-alanyl-D-alanine carboxypeptidase
HMPREF9154_2782	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HMPREF9154_2792	COG1136	(ABC) transporter
HMPREF9154_2792	COG0577	efflux transmembrane transporter activity
HMPREF9154_2796	COG1609	Transcriptional regulator
HMPREF9154_2799	COG2211	Major facilitator Superfamily
HMPREF9154_2800	COG1252	NADH dehydrogenase
HMPREF9154_2802	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HMPREF9154_2803	COG1116	anion transmembrane transporter activity
HMPREF9154_2805	COG1131	(ABC) transporter
HMPREF9154_2808	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_2809	COG2205	protein histidine kinase activity
HMPREF9154_2810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF9154_2814	COG3433	isochorismatase activity
HMPREF9154_2814	COG2226	methyltransferase
HMPREF9154_2814	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HMPREF9154_2816	COG0318	PFAM AMP-dependent synthetase and ligase
HMPREF9154_2827	COG1129	ABC transporter
HMPREF9154_2830	COG1021	2,3-dihydroxybenzoate-AMP ligase
HMPREF9154_2831	COG1021	2,3-dihydroxybenzoate-AMP ligase
HMPREF9154_2832	COG2814	Major facilitator Superfamily
HMPREF9154_2834	COG1129	ABC transporter
HMPREF9154_2836	COG1132	(ABC) transporter
HMPREF9154_2836	COG2375	cellular response to nickel ion
HMPREF9154_2844	COG1132	(ABC) transporter
HMPREF9154_2847	COG0717	Belongs to the dCTP deaminase family
HMPREF9154_2853	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_2854	COG0601	transmembrane transport
HMPREF9154_2861	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMPREF9154_2864	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_2869	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF9154_2872	COG1120	ATPase activity
HMPREF9154_2873	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2878	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2879	COG1120	ATPase activity
HMPREF9154_2882	COG0433	COG0433 Predicted ATPase
HMPREF9154_2885	COG2197	response regulator
HMPREF9154_2886	COG4585	Histidine kinase
HMPREF9154_2887	COG1131	(ABC) transporter
HMPREF9154_2892	COG1132	(ABC) transporter
HMPREF9154_2894	COG1120	ATPase activity
HMPREF9154_2895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2896	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2897	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMPREF9154_2902	COG0732	type I restriction modification DNA specificity domain
HMPREF9154_2903	COG1715	Restriction endonuclease
HMPREF9154_2905	COG3311	Transcriptional regulator
HMPREF9154_2912	COG5564	TIM-barrel signal transduction protein
HMPREF9154_2914	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF9154_2915	COG3655	Transcriptional regulator
HMPREF9154_2917	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HMPREF9154_2920	COG1429	ligase activity, forming nitrogen-metal bonds
HMPREF9154_2921	COG1120	ATPase activity
HMPREF9154_2922	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_2936	COG1175	transmembrane transport
HMPREF9154_2940	COG1621	beta-fructofuranosidase activity
HMPREF9154_2943	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMPREF9154_2945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HMPREF9154_2946	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF9154_2950	COG1316	TRANSCRIPTIONal
HMPREF9154_2957	COG0137	argininosuccinate synthase activity
HMPREF9154_2960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HMPREF9154_2962	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_2967	COG1129	ABC transporter
HMPREF9154_2968	COG0667	Aldo Keto reductase
HMPREF9154_2969	COG0789	Transcriptional regulator
HMPREF9154_2974	COG4917	ethanolamine utilization protein
HMPREF9154_2985	COG4869	propanediol catabolic process
HMPREF9154_2988	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HMPREF9154_2991	COG0039	L-malate dehydrogenase activity
HMPREF9154_3008	COG1215	transferase activity, transferring glycosyl groups
HMPREF9154_3036	COG1674	ftsk spoiiie
HMPREF9154_3046	COG0442	prolyl-tRNA aminoacylation
HMPREF9154_3048	COG0574	Belongs to the PEP-utilizing enzyme family
HMPREF9154_3048	COG3848	Pyruvate phosphate dikinase
HMPREF9154_3053	COG3588	fructose-bisphosphate aldolase
HMPREF9154_3065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HMPREF9154_3067	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HMPREF9154_3068	COG1696	Membrane protein involved in D-alanine export
HMPREF9154_3070	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMPREF9154_3074	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9154_3076	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMPREF9154_3079	COG0733	neurotransmitter:sodium symporter activity
HMPREF9154_3081	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF9154_3082	COG1408	metallophosphoesterase
HMPREF9154_3085	COG3012	SEC-C Motif Domain Protein
HMPREF9154_3098	COG3883	PFAM NLP P60 protein
HMPREF9154_3098	COG0791	NLP P60 protein
HMPREF9154_3102	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF9154_3106	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF9154_3107	COG0653	protein targeting
HMPREF9154_3109	COG0521	Mo-molybdopterin cofactor biosynthetic process
HMPREF9154_3109	COG0315	cyclic pyranopterin monophosphate synthase activity
HMPREF9154_3118	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HMPREF9154_3121	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF9154_3123	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF9154_3138	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF9154_3144	COG2856	Zn peptidase
HMPREF9154_3150	COG0768	penicillin binding
HMPREF9154_3152	COG3527	Alpha-acetolactate decarboxylase
HMPREF9154_3156	COG1120	ATPase activity
HMPREF9154_3157	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_3158	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_3160	COG0783	Belongs to the Dps family
HMPREF9154_3161	COG2267	carboxylic ester hydrolase activity
HMPREF9154_3167	COG1321	iron dependent repressor
HMPREF9154_3169	COG1971	Probably functions as a manganese efflux pump
HMPREF9154_3171	COG1024	Enoyl-CoA hydratase
HMPREF9154_3172	COG1505	serine-type exopeptidase activity
HMPREF9154_3177	COG0492	ferredoxin-NADP+ reductase activity
HMPREF9154_3181	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF9154_3188	COG0357	Ribosomal RNA small subunit methyltransferase G
HMPREF9154_3190	COG0706	membrane insertase activity
HMPREF9154_3191	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HMPREF9154_3192	COG0594	ribonuclease P activity
HMPREF9154_3193	COG0230	Belongs to the bacterial ribosomal protein bL34 family