locus-tag	class	description
SK1NUM_00070	COG1122	ATPase activity
SK1NUM_00100	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SK1NUM_00130	COG0205	6-phosphofructokinase activity
SK1NUM_00170	COG0667	Aldo Keto reductase
SK1NUM_00190	COG1131	(ABC) transporter
SK1NUM_00210	COG2197	response regulator
SK1NUM_00280	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SK1NUM_00310	COG1429	ligase activity, forming nitrogen-metal bonds
SK1NUM_00320	COG1120	ATPase activity
SK1NUM_00330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_00410	COG1028	Short-chain dehydrogenase reductase Sdr
SK1NUM_00420	COG0604	alcohol dehydrogenase
SK1NUM_00440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SK1NUM_00450	COG1940	carbohydrate kinase activity
SK1NUM_00460	COG1063	alcohol dehydrogenase
SK1NUM_00490	COG0596	Alpha beta hydrolase
SK1NUM_00610	COG1131	(ABC) transporter
SK1NUM_00640	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_00780	COG3321	synthase
SK1NUM_00780	COG0604	alcohol dehydrogenase
SK1NUM_00810	COG0604	alcohol dehydrogenase
SK1NUM_00810	COG3321	synthase
SK1NUM_00890	COG1132	(ABC) transporter
SK1NUM_00900	COG1770	oligopeptidase
SK1NUM_00910	COG0577	efflux transmembrane transporter activity
SK1NUM_00910	COG1136	(ABC) transporter
SK1NUM_00930	COG2197	response regulator
SK1NUM_00950	COG1088	dTDP-glucose 4,6-dehydratase activity
SK1NUM_00960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SK1NUM_00970	COG0318	PFAM AMP-dependent synthetase and ligase
SK1NUM_01000	COG2814	Major facilitator Superfamily
SK1NUM_01010	COG0640	Transcriptional regulator
SK1NUM_01030	COG1309	transcriptional regulator
SK1NUM_01080	COG1122	ATPase activity
SK1NUM_01090	COG1132	(ABC) transporter
SK1NUM_01090	COG2375	cellular response to nickel ion
SK1NUM_01120	COG1309	transcriptional regulator
SK1NUM_01170	COG0346	lactoylglutathione lyase activity
SK1NUM_01330	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_01400	COG2197	response regulator
SK1NUM_01480	COG2376	Dihydroxyacetone kinase
SK1NUM_01490	COG1063	alcohol dehydrogenase
SK1NUM_01520	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
SK1NUM_01530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SK1NUM_01630	COG1116	anion transmembrane transporter activity
SK1NUM_01660	COG0477	Major facilitator Superfamily
SK1NUM_01690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SK1NUM_01700	COG0596	Alpha beta hydrolase
SK1NUM_01710	COG3311	Transcriptional regulator
SK1NUM_01730	COG0667	Aldo Keto reductase
SK1NUM_01750	COG1621	beta-fructofuranosidase activity
SK1NUM_01760	COG3001	Fructosamine kinase
SK1NUM_02010	COG2161	toxin-antitoxin pair type II binding
SK1NUM_02020	COG2026	Addiction module toxin, RelE StbE family
SK1NUM_02180	COG0574	Belongs to the PEP-utilizing enzyme family
SK1NUM_02180	COG3848	Pyruvate phosphate dikinase
SK1NUM_02190	COG1309	transcriptional regulator
SK1NUM_02230	COG1131	(ABC) transporter
SK1NUM_02250	COG2197	response regulator
SK1NUM_02280	COG4558	Periplasmic binding protein
SK1NUM_02290	COG1120	ATPase activity
SK1NUM_02300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_02320	COG4221	oxidoreductase activity
SK1NUM_02330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SK1NUM_02360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SK1NUM_02380	COG4585	Histidine kinase
SK1NUM_02390	COG2197	response regulator
SK1NUM_02410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SK1NUM_02460	COG0673	inositol 2-dehydrogenase activity
SK1NUM_02470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SK1NUM_02500	COG2197	response regulator
SK1NUM_02550	COG4585	Histidine kinase
SK1NUM_02600	COG2188	Transcriptional regulator
SK1NUM_02610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SK1NUM_02620	COG3718	enzyme involved in inositol metabolism
SK1NUM_02630	COG3962	Belongs to the TPP enzyme family
SK1NUM_02670	COG1131	(ABC) transporter
SK1NUM_02730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SK1NUM_02810	COG1175	transmembrane transport
SK1NUM_02820	COG0395	ABC-type sugar transport system, permease component
SK1NUM_02910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SK1NUM_02990	COG2184	nucleotidyltransferase activity
SK1NUM_03000	COG1215	transferase activity, transferring glycosyl groups
SK1NUM_03120	COG1902	pentaerythritol trinitrate reductase activity
SK1NUM_03210	COG1487	ribonuclease activity
SK1NUM_03260	COG0438	transferase activity, transferring glycosyl groups
SK1NUM_03270	COG1132	(ABC) transporter
SK1NUM_03290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SK1NUM_03300	COG5002	protein histidine kinase activity
SK1NUM_03360	COG3266	domain, Protein
SK1NUM_03420	COG1674	ftsk spoiiie
SK1NUM_03540	COG1172	Belongs to the binding-protein-dependent transport system permease family
SK1NUM_03550	COG1129	ABC transporter
SK1NUM_03590	COG1082	Xylose isomerase domain protein TIM barrel
SK1NUM_03600	COG0673	inositol 2-dehydrogenase activity
SK1NUM_03620	COG0673	inositol 2-dehydrogenase activity
SK1NUM_03680	COG0305	Participates in initiation and elongation during chromosome replication
SK1NUM_03700	COG1937	Protein conserved in bacteria
SK1NUM_03730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SK1NUM_03800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SK1NUM_03810	COG4988	ABC transporter
SK1NUM_03820	COG1294	oxidase, subunit
SK1NUM_03830	COG1271	oxidase subunit
SK1NUM_03870	COG1028	Short-chain dehydrogenase reductase Sdr
SK1NUM_03890	COG3328	transposase activity
SK1NUM_03910	COG1944	ATP diphosphatase activity
SK1NUM_03950	COG1132	(ABC) transporter
SK1NUM_04030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SK1NUM_04050	COG1027	Aspartate ammonia-lyase
SK1NUM_04080	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SK1NUM_04090	COG1940	carbohydrate kinase activity
SK1NUM_04120	COG1175	transmembrane transport
SK1NUM_04140	COG1940	carbohydrate kinase activity
SK1NUM_04190	COG0366	Alpha amylase catalytic
SK1NUM_04230	COG2205	protein histidine kinase activity
SK1NUM_04270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SK1NUM_04290	COG0022	dehydrogenase e1 component
SK1NUM_04300	COG0508	dehydrogenase complex catalyzes the overall conversion of
SK1NUM_04320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SK1NUM_04340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SK1NUM_04370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SK1NUM_04380	COG0561	phosphatase activity
SK1NUM_04430	COG0494	nUDIX hydrolase
SK1NUM_04500	COG1205	dead DEAH box helicase
SK1NUM_04500	COG1111	helicase
SK1NUM_04540	COG2890	protein-(glutamine-N5) methyltransferase activity
SK1NUM_04640	COG5564	TIM-barrel signal transduction protein
SK1NUM_04660	COG0406	alpha-ribazole phosphatase activity
SK1NUM_04680	COG1595	DNA-templated transcription, initiation
SK1NUM_04690	COG1252	NADH dehydrogenase
SK1NUM_04710	COG0302	gtp cyclohydrolase
SK1NUM_04730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SK1NUM_04800	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SK1NUM_04820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SK1NUM_04840	COG1082	Xylose isomerase domain protein TIM barrel
SK1NUM_04880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SK1NUM_04910	COG0406	alpha-ribazole phosphatase activity
SK1NUM_04930	COG4221	oxidoreductase activity
SK1NUM_04970	COG3550	peptidyl-serine autophosphorylation
SK1NUM_04990	COG1131	(ABC) transporter
SK1NUM_05000	COG4585	Histidine kinase
SK1NUM_05010	COG2197	response regulator
SK1NUM_05060	COG0577	efflux transmembrane transporter activity
SK1NUM_05060	COG1136	(ABC) transporter
SK1NUM_05060	COG0577	efflux transmembrane transporter activity
SK1NUM_05060	COG1136	(ABC) transporter
SK1NUM_05110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SK1NUM_05200	COG0395	ABC-type sugar transport system, permease component
SK1NUM_05210	COG1175	transmembrane transport
SK1NUM_05230	COG1940	carbohydrate kinase activity
SK1NUM_05240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SK1NUM_05260	COG0494	nUDIX hydrolase
SK1NUM_05260	COG0406	alpha-ribazole phosphatase activity
SK1NUM_05270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SK1NUM_05280	COG0456	acetyltransferase
SK1NUM_05290	COG0745	RESPONSE REGULATOR receiver
SK1NUM_05320	COG0025	NhaP-type Na H and K H
SK1NUM_05330	COG3104	oligopeptide transport
SK1NUM_05370	COG1966	Carbon starvation protein
SK1NUM_05380	COG1490	D-aminoacyl-tRNA deacylase activity
SK1NUM_05400	COG3485	protocatechuate 3,4-dioxygenase
SK1NUM_05410	COG0354	folic acid binding
SK1NUM_05420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SK1NUM_05430	COG2326	polyphosphate kinase activity
SK1NUM_05450	COG0583	DNA-binding transcription factor activity
SK1NUM_05520	COG1217	gtp-binding protein TYPA
SK1NUM_05560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SK1NUM_05570	COG1461	Dihydroxyacetone kinase
SK1NUM_05580	COG2376	Dihydroxyacetone kinase
SK1NUM_05590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SK1NUM_05670	COG3311	Transcriptional regulator
SK1NUM_05690	COG0151	Belongs to the GarS family
SK1NUM_05710	COG0577	efflux transmembrane transporter activity
SK1NUM_05710	COG1136	(ABC) transporter
SK1NUM_05770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SK1NUM_05810	COG4152	abc transporter atp-binding protein
SK1NUM_05820	COG2197	response regulator
SK1NUM_05830	COG4585	Histidine kinase
SK1NUM_05860	COG1175	transmembrane transport
SK1NUM_05870	COG0395	ABC-type sugar transport system, permease component
SK1NUM_05920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SK1NUM_05940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SK1NUM_05950	COG0047	phosphoribosylformylglycinamidine synthase activity
SK1NUM_05980	COG0857	belongs to the CobB CobQ family
SK1NUM_05980	COG0280	phosphate acetyltransferase
SK1NUM_06020	COG1454	alcohol dehydrogenase
SK1NUM_06020	COG1012	belongs to the aldehyde dehydrogenase family
SK1NUM_06070	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SK1NUM_06110	COG0427	acetyl-CoA hydrolase
SK1NUM_06150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SK1NUM_06170	COG1331	Highly conserved protein containing a thioredoxin domain
SK1NUM_06190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SK1NUM_06200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SK1NUM_06310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SK1NUM_06320	COG0484	heat shock protein binding
SK1NUM_06330	COG0789	Transcriptional regulator
SK1NUM_06340	COG0366	Alpha amylase catalytic
SK1NUM_06370	COG1175	transmembrane transport
SK1NUM_06380	COG3833	ABC-type maltose transport systems, permease component
SK1NUM_06410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SK1NUM_06420	COG0477	Major facilitator Superfamily
SK1NUM_06440	COG2838	Isocitrate dehydrogenase
SK1NUM_06470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SK1NUM_06550	COG0166	Belongs to the GPI family
SK1NUM_06630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SK1NUM_06640	COG2011	ABC-type metal ion transport system permease component
SK1NUM_06650	COG1464	Belongs to the NlpA lipoprotein family
SK1NUM_06670	COG1473	amidohydrolase
SK1NUM_06700	COG0560	Phosphoserine phosphatase
SK1NUM_06700	COG3830	Belongs to the UPF0237 family
SK1NUM_06710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SK1NUM_06720	COG2813	Specifically methylates the guanine in position
SK1NUM_06750	COG0840	transmembrane signaling receptor activity
SK1NUM_06780	COG0515	serine threonine protein kinase
SK1NUM_06870	COG4977	sequence-specific DNA binding
SK1NUM_06910	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_06920	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_06930	COG2814	Major facilitator Superfamily
SK1NUM_06940	COG3654	unkown
SK1NUM_06970	COG2197	response regulator
SK1NUM_07000	COG3059	membrane
SK1NUM_07030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SK1NUM_07060	COG1070	Carbohydrate kinase
SK1NUM_07080	COG1487	ribonuclease activity
SK1NUM_07120	COG2197	response regulator
SK1NUM_07140	COG1131	(ABC) transporter
SK1NUM_07160	COG0477	Major facilitator Superfamily
SK1NUM_07180	COG0076	glutamate decarboxylase activity
SK1NUM_07190	COG2056	Na+-H+ antiporter family
SK1NUM_07260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SK1NUM_07270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SK1NUM_07280	COG2197	response regulator
SK1NUM_07290	COG4585	Histidine kinase
SK1NUM_07340	COG1122	ATPase activity
SK1NUM_07370	COG1309	transcriptional regulator
SK1NUM_07380	COG2409	Drug exporters of the RND superfamily
SK1NUM_07400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SK1NUM_07410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SK1NUM_07430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SK1NUM_07480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SK1NUM_07500	COG1461	Dihydroxyacetone kinase
SK1NUM_07520	COG0318	PFAM AMP-dependent synthetase and ligase
SK1NUM_07530	COG1575	Belongs to the MenA family. Type 1 subfamily
SK1NUM_07540	COG4948	Mandelate Racemase Muconate Lactonizing
SK1NUM_07550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SK1NUM_07570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SK1NUM_07580	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SK1NUM_07590	COG0488	(ABC) transporter
SK1NUM_07620	COG2226	methyltransferase
SK1NUM_07640	COG1116	anion transmembrane transporter activity
SK1NUM_07680	COG1169	isochorismate synthase
SK1NUM_07710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SK1NUM_07720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SK1NUM_07730	COG0649	NAD binding
SK1NUM_07750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SK1NUM_07760	COG1034	ATP synthesis coupled electron transport
SK1NUM_07770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SK1NUM_07780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SK1NUM_07790	COG0839	Belongs to the complex I subunit 6 family
SK1NUM_07800	COG0713	ATP synthesis coupled electron transport
SK1NUM_07830	COG1007	ATP synthesis coupled electron transport
SK1NUM_07840	COG0142	geranyltranstransferase activity
SK1NUM_07860	COG0254	rRNA binding
SK1NUM_07870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SK1NUM_07880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SK1NUM_07890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SK1NUM_08010	COG1013	pyruvate-flavodoxin oxidoreductase activity
SK1NUM_08020	COG0674	pyruvate-flavodoxin oxidoreductase activity
SK1NUM_08020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SK1NUM_08050	COG0708	Exodeoxyribonuclease III
SK1NUM_08060	COG2354	Protein conserved in bacteria
SK1NUM_08070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SK1NUM_08070	COG4106	trans-aconitate 2-methyltransferase activity
SK1NUM_08080	COG2188	Transcriptional regulator
SK1NUM_08100	COG3214	Protein conserved in bacteria
SK1NUM_08110	COG1666	GTP binding
SK1NUM_08120	COG2190	(PTS) system
SK1NUM_08120	COG2211	Major facilitator Superfamily
SK1NUM_08130	COG0789	Transcriptional regulator
SK1NUM_08150	COG1022	Amp-dependent synthetase and ligase
SK1NUM_08160	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SK1NUM_08190	COG0778	Nitroreductase
SK1NUM_08210	COG0577	efflux transmembrane transporter activity
SK1NUM_08210	COG1136	(ABC) transporter
SK1NUM_08240	COG0360	Binds together with S18 to 16S ribosomal RNA
SK1NUM_08250	COG0629	single-stranded DNA binding
SK1NUM_08260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SK1NUM_08270	COG0359	binds to the 23S rRNA
SK1NUM_08290	COG0737	Belongs to the 5'-nucleotidase family
SK1NUM_08350	COG0371	Dehydrogenase
SK1NUM_08370	COG3732	PTS system glucitol sorbitol-specific
SK1NUM_08380	COG3730	PTS system glucitol sorbitol-specific
SK1NUM_08410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SK1NUM_08450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SK1NUM_08460	COG2030	dehydratase
SK1NUM_08480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SK1NUM_08500	COG0250	Participates in transcription elongation, termination and antitermination
SK1NUM_08510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SK1NUM_08520	COG0081	regulation of translation
SK1NUM_08530	COG1132	(ABC) transporter
SK1NUM_08540	COG1132	(ABC) transporter
SK1NUM_08550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SK1NUM_08560	COG0222	ribosome binding
SK1NUM_08600	COG0085	RNA polymerase activity
SK1NUM_08610	COG0085	RNA polymerase activity
SK1NUM_08620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SK1NUM_08630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SK1NUM_08640	COG0049	tRNA binding
SK1NUM_08650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SK1NUM_08670	COG0698	ribose 5-phosphate isomerase
SK1NUM_08680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SK1NUM_08700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SK1NUM_08720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SK1NUM_08730	COG1126	abc transporter atp-binding protein
SK1NUM_08740	COG0765	amino acid transport
SK1NUM_08750	COG0765	amino acid transport
SK1NUM_08810	COG1846	Transcriptional regulator
SK1NUM_08820	COG0604	alcohol dehydrogenase
SK1NUM_08840	COG1136	(ABC) transporter
SK1NUM_08860	COG2197	response regulator
SK1NUM_08870	COG0051	transcription antitermination factor activity, RNA binding
SK1NUM_08880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SK1NUM_08890	COG0088	Forms part of the polypeptide exit tunnel
SK1NUM_08900	COG0089	rRNA binding
SK1NUM_08910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SK1NUM_08920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SK1NUM_08930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SK1NUM_08940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SK1NUM_08950	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SK1NUM_08960	COG0255	Belongs to the universal ribosomal protein uL29 family
SK1NUM_08970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SK1NUM_08980	COG1528	Iron-storage protein
SK1NUM_09000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SK1NUM_09010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SK1NUM_09020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SK1NUM_09030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SK1NUM_09040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SK1NUM_09050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SK1NUM_09060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SK1NUM_09070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SK1NUM_09080	COG1841	ribosomal large subunit assembly
SK1NUM_09100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SK1NUM_09120	COG0563	adenylate kinase activity
SK1NUM_09130	COG0024	Methionine aminopeptidase
SK1NUM_09160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SK1NUM_09170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SK1NUM_09180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SK1NUM_09190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SK1NUM_09200	COG0202	RNA polymerase activity
SK1NUM_09210	COG0203	ribosomal protein L17
SK1NUM_09270	COG0656	L-ascorbic acid biosynthetic process
SK1NUM_09280	COG1028	Short-chain dehydrogenase reductase Sdr
SK1NUM_09320	COG0101	tRNA pseudouridine synthase activity
SK1NUM_09330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SK1NUM_09350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_09360	COG1120	ATPase activity
SK1NUM_09400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SK1NUM_09400	COG2169	Transcriptional regulator
SK1NUM_09410	COG2197	response regulator
SK1NUM_09430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SK1NUM_09440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SK1NUM_09450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SK1NUM_09460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SK1NUM_09470	COG1072	(Pantothenic acid kinase))
SK1NUM_09480	COG1335	isochorismatase
SK1NUM_09490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SK1NUM_09490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SK1NUM_09500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SK1NUM_09510	COG0736	holo-[acyl-carrier-protein] synthase activity
SK1NUM_09570	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_09690	COG1640	4-alpha-glucanotransferase
SK1NUM_09720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SK1NUM_09770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SK1NUM_09860	COG0667	Aldo Keto reductase
SK1NUM_09870	COG0366	Alpha amylase catalytic
SK1NUM_09900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SK1NUM_09960	COG0513	Belongs to the DEAD box helicase family
SK1NUM_09970	COG0802	atpase or kinase
SK1NUM_09980	COG0456	acetyltransferase
SK1NUM_09980	COG1214	PFAM Peptidase M22, glycoprotease
SK1NUM_10000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SK1NUM_10010	COG4166	transmembrane transport
SK1NUM_10030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SK1NUM_10070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SK1NUM_10080	COG0459	protein refolding
SK1NUM_10140	COG1486	melibiose metabolic process
SK1NUM_10190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SK1NUM_10230	COG2860	membrane
SK1NUM_10290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_10300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_10310	COG1120	ATPase activity
SK1NUM_10320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SK1NUM_10340	COG3226	Transcriptional regulator
SK1NUM_10380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SK1NUM_10380	COG0519	Catalyzes the synthesis of GMP from XMP
SK1NUM_10390	COG1983	PspC domain protein
SK1NUM_10420	COG2205	protein histidine kinase activity
SK1NUM_10430	COG2197	response regulator
SK1NUM_10450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SK1NUM_10470	COG0739	heme binding
SK1NUM_10510	COG0138	bifunctional purine biosynthesis protein purh
SK1NUM_10520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SK1NUM_10540	COG0039	L-malate dehydrogenase activity
SK1NUM_10550	COG0508	dehydrogenase complex catalyzes the overall conversion of
SK1NUM_10560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SK1NUM_10600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SK1NUM_10690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SK1NUM_10710	COG0088	Forms part of the polypeptide exit tunnel
SK1NUM_10720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SK1NUM_10750	COG0204	Acyl-transferase
SK1NUM_10770	COG2197	response regulator
SK1NUM_10780	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SK1NUM_10800	COG0515	serine threonine protein kinase
SK1NUM_10800	COG2815	serine threonine protein kinase
SK1NUM_10820	COG4592	Periplasmic binding protein
SK1NUM_10830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_10840	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_10850	COG1120	ATPase activity
SK1NUM_10870	COG0142	geranyltranstransferase activity
SK1NUM_10890	COG3973	AAA domain
SK1NUM_10900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SK1NUM_10900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SK1NUM_10920	COG0667	Aldo Keto reductase
SK1NUM_10930	COG1968	undecaprenyl-diphosphatase activity
SK1NUM_10950	COG0215	cysteine-tRNA ligase activity
SK1NUM_10960	COG0140	phosphoribosyl-ATP diphosphatase activity
SK1NUM_10970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SK1NUM_11020	COG1120	ATPase activity
SK1NUM_11050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_11070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SK1NUM_11080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SK1NUM_11090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SK1NUM_11100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SK1NUM_11110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SK1NUM_11120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SK1NUM_11120	COG0072	phenylalanine-tRNA ligase activity
SK1NUM_11130	COG0072	phenylalanine-tRNA ligase activity
SK1NUM_11130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SK1NUM_11160	COG0495	leucyl-tRNA aminoacylation
SK1NUM_11180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SK1NUM_11190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SK1NUM_11200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SK1NUM_11210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SK1NUM_11230	COG0165	Argininosuccinate lyase
SK1NUM_11260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SK1NUM_11290	COG0647	UMP catabolic process
SK1NUM_11310	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SK1NUM_11320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SK1NUM_11330	COG0497	DNA recombination
SK1NUM_11340	COG1335	isochorismatase
SK1NUM_11420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SK1NUM_11430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SK1NUM_11450	COG0545	Peptidyl-prolyl cis-trans isomerase
SK1NUM_11460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SK1NUM_11470	COG2378	regulation of single-species biofilm formation
SK1NUM_11510	COG0805	protein transport
SK1NUM_11530	COG4581	dead DEAH box helicase
SK1NUM_11540	COG0107	imidazoleglycerol-phosphate synthase activity
SK1NUM_11550	COG0537	adenosine 5'-monophosphoramidase activity
SK1NUM_11570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SK1NUM_11590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SK1NUM_11600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SK1NUM_11630	COG0129	dihydroxy-acid dehydratase activity
SK1NUM_11680	COG1643	Atp-dependent helicase
SK1NUM_11690	COG1946	Acyl-CoA thioesterase
SK1NUM_11710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SK1NUM_11740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SK1NUM_11750	COG1074	ATP-dependent DNA helicase activity
SK1NUM_11790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SK1NUM_11810	COG1615	UPF0182 protein
SK1NUM_11820	COG1615	UPF0182 protein
SK1NUM_11880	COG0714	Associated with various cellular activities
SK1NUM_11890	COG2001	Belongs to the MraZ family
SK1NUM_11910	COG0275	rRNA processing
SK1NUM_11940	COG0768	penicillin binding
SK1NUM_11950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SK1NUM_11960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SK1NUM_11970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SK1NUM_11980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SK1NUM_11990	COG0772	Belongs to the SEDS family
SK1NUM_12000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SK1NUM_12010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SK1NUM_12040	COG1799	cell septum assembly
SK1NUM_12100	COG0469	pyruvate kinase activity
SK1NUM_12120	COG2050	protein possibly involved in aromatic compounds catabolism
SK1NUM_12150	COG0539	negative regulation of cytoplasmic translation
SK1NUM_12160	COG0539	negative regulation of cytoplasmic translation
SK1NUM_12170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SK1NUM_12170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SK1NUM_12180	COG0509	glycine decarboxylation via glycine cleavage system
SK1NUM_12190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SK1NUM_12210	COG0237	dephospho-CoA kinase activity
SK1NUM_12220	COG0556	nucleotide-excision repair
SK1NUM_12250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SK1NUM_12260	COG2197	response regulator
SK1NUM_12280	COG1131	(ABC) transporter
SK1NUM_12320	COG0247	lactate metabolic process
SK1NUM_12320	COG0277	FAD linked oxidase domain protein
SK1NUM_12340	COG1022	Amp-dependent synthetase and ligase
SK1NUM_12360	COG0583	DNA-binding transcription factor activity
SK1NUM_12390	COG1201	RNA secondary structure unwinding
SK1NUM_12400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SK1NUM_12420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SK1NUM_12430	COG0540	Belongs to the ATCase OTCase family
SK1NUM_12450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SK1NUM_12460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SK1NUM_12520	COG0701	Predicted permease
SK1NUM_12560	COG0371	Dehydrogenase
SK1NUM_12570	COG1070	Carbohydrate kinase
SK1NUM_12580	COG0647	UMP catabolic process
SK1NUM_12600	COG0698	ribose 5-phosphate isomerase
SK1NUM_12610	COG1349	DNA-binding transcription factor activity
SK1NUM_12620	COG0586	Pfam SNARE associated Golgi protein
SK1NUM_12630	COG1950	PFAM Membrane protein of
SK1NUM_12650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SK1NUM_12660	COG0544	peptidyl-prolyl cis-trans isomerase activity
SK1NUM_12670	COG0628	permease
SK1NUM_12680	COG0740	serine-type endopeptidase activity
SK1NUM_12690	COG0740	serine-type endopeptidase activity
SK1NUM_12700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SK1NUM_12710	COG0793	Belongs to the peptidase S41A family
SK1NUM_12710	COG4946	Tricorn protease homolog
SK1NUM_12720	COG0525	valine-tRNA ligase activity
SK1NUM_12750	COG0285	dihydrofolate synthase activity
SK1NUM_12790	COG1530	ribonuclease E activity
SK1NUM_12790	COG1530	ribonuclease E activity
SK1NUM_12800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SK1NUM_12810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SK1NUM_12830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SK1NUM_12840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SK1NUM_12850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SK1NUM_12860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SK1NUM_12870	COG0799	negative regulation of ribosome biogenesis
SK1NUM_12950	COG0656	L-ascorbic acid biosynthetic process
SK1NUM_12980	COG3253	May function as heme-dependent peroxidase
SK1NUM_12980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SK1NUM_12990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SK1NUM_13000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SK1NUM_13010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SK1NUM_13030	COG0181	hydroxymethylbilane synthase activity
SK1NUM_13040	COG0113	porphobilinogen synthase activity
SK1NUM_13050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SK1NUM_13080	COG1846	Transcriptional regulator
SK1NUM_13090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SK1NUM_13110	COG1819	glycosyl
SK1NUM_13120	COG2855	membrane
SK1NUM_13130	COG1760	l-serine dehydratase
SK1NUM_13170	COG2814	Major facilitator Superfamily
SK1NUM_13180	COG0640	Transcriptional regulator
SK1NUM_13230	COG3773	Cell wall hydrolase
SK1NUM_13230	COG3409	Peptidoglycan-binding domain 1 protein
SK1NUM_13270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SK1NUM_13280	COG2197	response regulator
SK1NUM_13350	COG4868	Belongs to the UPF0371 family
SK1NUM_13360	COG0268	Binds directly to 16S ribosomal RNA
SK1NUM_13370	COG0481	GTPase activity
SK1NUM_13390	COG1175	transmembrane transport
SK1NUM_13430	COG2318	DinB family
SK1NUM_13450	COG4221	oxidoreductase activity
SK1NUM_13470	COG1131	(ABC) transporter
SK1NUM_13500	COG0483	inositol monophosphate 1-phosphatase activity
SK1NUM_13520	COG1420	regulation of RNA biosynthetic process
SK1NUM_13530	COG0484	heat shock protein binding
SK1NUM_13550	COG1597	lipid kinase activity
SK1NUM_13560	COG0343	queuine tRNA-ribosyltransferase activity
SK1NUM_13600	COG1609	Transcriptional regulator
SK1NUM_13610	COG0673	inositol 2-dehydrogenase activity
SK1NUM_13640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SK1NUM_13660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SK1NUM_13670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SK1NUM_13680	COG1408	metallophosphoesterase
SK1NUM_13760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SK1NUM_13780	COG0366	Alpha amylase catalytic
SK1NUM_13810	COG2326	polyphosphate kinase activity
SK1NUM_13820	COG1104	cysteine desulfurase activity
SK1NUM_13830	COG0482	sulfurtransferase activity
SK1NUM_13880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SK1NUM_13890	COG0154	amidase activity
SK1NUM_13900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SK1NUM_13910	COG3548	integral membrane protein
SK1NUM_13930	COG1690	Belongs to the RtcB family
SK1NUM_13940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SK1NUM_13950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SK1NUM_13960	COG0134	indole-3-glycerol-phosphate synthase activity
SK1NUM_13970	COG0133	tryptophan synthase activity
SK1NUM_13990	COG2197	response regulator
SK1NUM_14020	COG0587	DNA-directed DNA polymerase activity
SK1NUM_14040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SK1NUM_14050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SK1NUM_14060	COG0131	Imidazoleglycerol-phosphate dehydratase
SK1NUM_14070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SK1NUM_14080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SK1NUM_14090	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SK1NUM_14100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SK1NUM_14140	COG0456	acetyltransferase
SK1NUM_14150	COG0217	transcriptional regulatory protein
SK1NUM_14160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SK1NUM_14170	COG0632	four-way junction helicase activity
SK1NUM_14180	COG2255	four-way junction helicase activity
SK1NUM_14200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SK1NUM_14210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SK1NUM_14220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SK1NUM_14240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SK1NUM_14270	COG1196	nuclear chromosome segregation
SK1NUM_14290	COG0124	histidyl-tRNA synthetase
SK1NUM_14320	COG2837	iron assimilation
SK1NUM_14330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SK1NUM_14350	COG2814	Major facilitator Superfamily
SK1NUM_14390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SK1NUM_14400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SK1NUM_14410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SK1NUM_14420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SK1NUM_14430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SK1NUM_14440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SK1NUM_14450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SK1NUM_14460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SK1NUM_14470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SK1NUM_14480	COG0505	Belongs to the CarA family
SK1NUM_14490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SK1NUM_14500	COG0167	dihydroorotate dehydrogenase activity
SK1NUM_14510	COG0284	orotidine-5'-phosphate decarboxylase activity
SK1NUM_14530	COG0194	GDP metabolic process
SK1NUM_14540	COG1758	RNA polymerase activity
SK1NUM_14550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SK1NUM_14570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SK1NUM_14590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SK1NUM_14650	COG0646	methionine synthase
SK1NUM_14650	COG1410	methionine synthase
SK1NUM_14660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SK1NUM_14690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SK1NUM_14700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SK1NUM_14710	COG1160	GTP binding
SK1NUM_14720	COG0702	epimerase
SK1NUM_14750	COG1114	Component of the transport system for branched-chain amino acids
SK1NUM_14760	COG1376	ErfK ybiS ycfS ynhG family protein
SK1NUM_14770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SK1NUM_14770	COG2111	Na H antiporter
SK1NUM_14780	COG1006	Multisubunit Na H antiporter MnhC subunit
SK1NUM_14790	COG0651	ATP synthesis coupled electron transport
SK1NUM_14800	COG1863	multisubunit Na H antiporter MnhE subunit
SK1NUM_14810	COG2212	antiporter activity
SK1NUM_14830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SK1NUM_14840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SK1NUM_14840	COG2813	Specifically methylates the guanine in position
SK1NUM_14850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SK1NUM_14860	COG1216	Glycosyl transferase, family 2
SK1NUM_14870	COG3030	protein affecting phage T7 exclusion by the F plasmid
SK1NUM_14900	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SK1NUM_14940	COG4552	Acetyltransferase involved in intracellular survival and related
SK1NUM_14970	COG0009	L-threonylcarbamoyladenylate synthase
SK1NUM_15000	COG0205	6-phosphofructokinase activity
SK1NUM_15060	COG1716	ATPase activity
SK1NUM_15120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SK1NUM_15160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SK1NUM_15180	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SK1NUM_15190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SK1NUM_15200	COG1113	amino acid transport
SK1NUM_15210	COG0686	Belongs to the AlaDH PNT family
SK1NUM_15220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SK1NUM_15230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SK1NUM_15240	COG0531	amino acid
SK1NUM_15250	COG0569	domain protein
SK1NUM_15290	COG0756	dUTP diphosphatase activity
SK1NUM_15340	COG1435	thymidine kinase activity
SK1NUM_15390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SK1NUM_15460	COG1278	Cold shock
SK1NUM_15500	COG0513	Belongs to the DEAD box helicase family
SK1NUM_15510	COG0180	Tryptophanyl-tRNA synthetase
SK1NUM_15520	COG0613	PHP domain protein
SK1NUM_15560	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_15610	COG0653	protein targeting
SK1NUM_15620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SK1NUM_15640	COG5401	PFAM Sporulation and spore germination
SK1NUM_15650	COG5002	protein histidine kinase activity
SK1NUM_15660	COG0745	RESPONSE REGULATOR receiver
SK1NUM_15670	COG1678	Uncharacterized ACR, COG1678
SK1NUM_15720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SK1NUM_15750	COG2884	Cell division ATP-binding protein ftsE
SK1NUM_15760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SK1NUM_15800	COG0205	6-phosphofructokinase activity
SK1NUM_15820	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SK1NUM_15840	COG1653	transport
SK1NUM_15870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SK1NUM_15880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SK1NUM_15920	COG2304	oxidoreductase activity
SK1NUM_15930	COG2304	oxidoreductase activity
SK1NUM_15950	COG0714	Associated with various cellular activities
SK1NUM_16010	COG1929	Belongs to the glycerate kinase type-1 family
SK1NUM_16080	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SK1NUM_16080	COG3266	domain, Protein
SK1NUM_16080	COG4932	domain protein
SK1NUM_16120	COG0358	DNA primase activity
SK1NUM_16130	COG2197	response regulator
SK1NUM_16140	COG4585	Histidine kinase
SK1NUM_16160	COG1131	(ABC) transporter
SK1NUM_16170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SK1NUM_16200	COG0339	signal peptide processing
SK1NUM_16210	COG1940	carbohydrate kinase activity
SK1NUM_16250	COG1175	transmembrane transport
SK1NUM_16300	COG3328	transposase activity
SK1NUM_16330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SK1NUM_16360	COG1381	Involved in DNA repair and RecF pathway recombination
SK1NUM_16370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SK1NUM_16460	COG0596	Alpha beta hydrolase
SK1NUM_16470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SK1NUM_16500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SK1NUM_16510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SK1NUM_16520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SK1NUM_16530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SK1NUM_16540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SK1NUM_16550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SK1NUM_16560	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SK1NUM_16570	COG0356	it plays a direct role in the translocation of protons across the membrane
SK1NUM_16600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SK1NUM_16620	COG2890	protein-(glutamine-N5) methyltransferase activity
SK1NUM_16630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SK1NUM_16640	COG0254	rRNA binding
SK1NUM_16660	COG0083	homoserine kinase activity
SK1NUM_16670	COG0460	homoserine dehydrogenase
SK1NUM_16710	COG0508	dehydrogenase complex catalyzes the overall conversion of
SK1NUM_16710	COG0567	Dehydrogenase, E1 component
SK1NUM_16720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SK1NUM_16760	COG1595	DNA-templated transcription, initiation
SK1NUM_16780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SK1NUM_16790	COG1162	GTPase activity
SK1NUM_16800	COG0483	inositol monophosphate 1-phosphatase activity
SK1NUM_16810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SK1NUM_16820	COG4608	Belongs to the ABC transporter superfamily
SK1NUM_16840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SK1NUM_16860	COG0747	negative chemotaxis
SK1NUM_16890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SK1NUM_16910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SK1NUM_16930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SK1NUM_16940	COG2017	converts alpha-aldose to the beta-anomer
SK1NUM_16950	COG1418	mRNA catabolic process
SK1NUM_16960	COG2137	regulation of response to DNA damage stimulus
SK1NUM_17010	COG1674	ftsk spoiiie
SK1NUM_17020	COG3585	molybdate ion transport
SK1NUM_17070	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_17080	COG1120	ATPase activity
SK1NUM_17090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_17100	COG0673	inositol 2-dehydrogenase activity
SK1NUM_17120	COG0066	3-isopropylmalate dehydratase activity
SK1NUM_17130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SK1NUM_17140	COG1414	Transcriptional regulator
SK1NUM_17170	COG0179	Fumarylacetoacetate (FAA) hydrolase
SK1NUM_17220	COG0477	Major facilitator Superfamily
SK1NUM_17230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SK1NUM_17240	COG0440	acetolactate synthase activity
SK1NUM_17250	COG0028	Belongs to the TPP enzyme family
SK1NUM_17260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SK1NUM_17300	COG0792	nuclease activity
SK1NUM_17320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SK1NUM_17340	COG0335	large ribosomal subunit rRNA binding
SK1NUM_17370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SK1NUM_17380	COG1053	succinate dehydrogenase
SK1NUM_17400	COG0336	Belongs to the RNA methyltransferase TrmD family
SK1NUM_17410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SK1NUM_17420	COG1837	Belongs to the UPF0109 family
SK1NUM_17430	COG0228	four-way junction DNA binding
SK1NUM_17480	COG2723	6-phospho-beta-galactosidase activity
SK1NUM_17490	COG0395	ABC-type sugar transport system, permease component
SK1NUM_17530	COG4585	Histidine kinase
SK1NUM_17560	COG2197	response regulator
SK1NUM_17580	COG1196	nuclear chromosome segregation
SK1NUM_17600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SK1NUM_17610	COG0571	ribonuclease III activity
SK1NUM_17630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SK1NUM_17650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SK1NUM_17670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SK1NUM_17680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SK1NUM_17690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SK1NUM_17710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SK1NUM_17720	COG1185	polyribonucleotide nucleotidyltransferase activity
SK1NUM_17730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SK1NUM_17750	COG1556	Lactate utilization protein
SK1NUM_17760	COG1139	Iron-sulfur cluster binding protein
SK1NUM_17770	COG0247	lactate metabolic process
SK1NUM_17780	COG1620	l-lactate permease
SK1NUM_17790	COG4106	trans-aconitate 2-methyltransferase activity
SK1NUM_17800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SK1NUM_17830	COG4139	cobalamin transport
SK1NUM_17850	COG2186	Transcriptional regulator
SK1NUM_17860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SK1NUM_17870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SK1NUM_17880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SK1NUM_17900	COG0195	Participates in both transcription termination and antitermination
SK1NUM_17910	COG0779	Required for maturation of 30S ribosomal subunits
SK1NUM_17930	COG2197	response regulator
SK1NUM_17970	COG0442	prolyl-tRNA aminoacylation
SK1NUM_17990	COG0456	acetyltransferase
SK1NUM_18000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SK1NUM_18020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SK1NUM_18020	COG1648	precorrin-2 dehydrogenase activity
SK1NUM_18030	COG1797	cobyrinic acid a,c-diamide synthase activity
SK1NUM_18040	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SK1NUM_18070	COG2875	Belongs to the precorrin methyltransferase family
SK1NUM_18140	COG0310	cobalt ion transport
SK1NUM_18170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SK1NUM_18180	COG0321	lipoyl(octanoyl) transferase activity
SK1NUM_18190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SK1NUM_18210	COG0110	maltose O-acetyltransferase activity
SK1NUM_18220	COG0488	(ABC) transporter
SK1NUM_18270	COG2391	methyltransferase activity
SK1NUM_18280	COG0425	Belongs to the sulfur carrier protein TusA family
SK1NUM_18290	COG2188	Transcriptional regulator
SK1NUM_18300	COG4821	SIS domain
SK1NUM_18360	COG1131	(ABC) transporter
SK1NUM_18370	COG0842	Transport permease protein
SK1NUM_18380	COG1309	transcriptional regulator
SK1NUM_18390	COG0174	glutamine synthetase
SK1NUM_18400	COG2409	Drug exporters of the RND superfamily
SK1NUM_18440	COG1823	symporter activity
SK1NUM_18460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SK1NUM_18470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SK1NUM_18480	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SK1NUM_18500	COG0174	glutamine synthetase
SK1NUM_18570	COG0006	proline dipeptidase activity
SK1NUM_18640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SK1NUM_18660	COG1595	DNA-templated transcription, initiation
SK1NUM_18670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SK1NUM_18700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SK1NUM_18710	COG0297	glycogen (starch) synthase activity
SK1NUM_18760	COG2171	N-acyltransferase activity
SK1NUM_18830	COG0616	signal peptide processing
SK1NUM_18860	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SK1NUM_18880	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SK1NUM_18900	COG0714	Associated with various cellular activities
SK1NUM_18980	COG1061	Type III restriction enzyme res subunit
SK1NUM_18990	COG1061	Type III restriction enzyme res subunit
SK1NUM_19010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SK1NUM_19030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SK1NUM_19050	COG1131	(ABC) transporter
SK1NUM_19060	COG0823	Involved in the tonB-independent uptake of proteins
SK1NUM_19060	COG1506	peptidase
SK1NUM_19060	COG4946	Tricorn protease homolog
SK1NUM_19080	COG0328	RNA-DNA hybrid ribonuclease activity
SK1NUM_19090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SK1NUM_19110	COG1079	Belongs to the binding-protein-dependent transport system permease family
SK1NUM_19120	COG4603	Belongs to the binding-protein-dependent transport system permease family
SK1NUM_19130	COG3845	ABC transporter
SK1NUM_19140	COG1744	ABC transporter substrate-binding protein PnrA-like
SK1NUM_19160	COG1253	flavin adenine dinucleotide binding
SK1NUM_19200	COG1492	cobalamin metabolic process
SK1NUM_19210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SK1NUM_19220	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SK1NUM_19240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SK1NUM_19250	COG0750	zinc metalloprotease
SK1NUM_19260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SK1NUM_19270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SK1NUM_19280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SK1NUM_19290	COG0575	Belongs to the CDS family
SK1NUM_19300	COG0233	cytoplasmic translational termination
SK1NUM_19310	COG0528	UMP kinase activity
SK1NUM_19320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SK1NUM_19330	COG0052	Belongs to the universal ribosomal protein uS2 family
SK1NUM_19340	COG0739	heme binding
SK1NUM_19340	COG1196	nuclear chromosome segregation
SK1NUM_19340	COG0741	lytic transglycosylase activity
SK1NUM_19350	COG4974	Belongs to the 'phage' integrase family
SK1NUM_19360	COG0242	peptide deformylase activity
SK1NUM_19400	COG0114	fumarate hydratase activity
SK1NUM_19410	COG1119	ATPase activity
SK1NUM_19430	COG1028	Short-chain dehydrogenase reductase Sdr
SK1NUM_19440	COG2226	methyltransferase
SK1NUM_19470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SK1NUM_19480	COG0488	(ABC) transporter
SK1NUM_19520	COG2267	carboxylic ester hydrolase activity
SK1NUM_19550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SK1NUM_19560	COG0396	ATPase activity
SK1NUM_19640	COG0363	glucosamine-6-phosphate deaminase activity
SK1NUM_19680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SK1NUM_19690	COG0149	triose-phosphate isomerase activity
SK1NUM_19700	COG0126	phosphoglycerate kinase activity
SK1NUM_19710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SK1NUM_19730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SK1NUM_19740	COG1660	Displays ATPase and GTPase activities
SK1NUM_19750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SK1NUM_19760	COG1122	ATPase activity
SK1NUM_19790	COG0322	excinuclease ABC activity
SK1NUM_19840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SK1NUM_19860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SK1NUM_19890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SK1NUM_19920	COG1739	Uncharacterized protein family UPF0029
SK1NUM_19960	COG0259	pyridoxamine-phosphate oxidase activity
SK1NUM_19980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SK1NUM_20000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SK1NUM_20010	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SK1NUM_20040	COG3831	ATPase activity
SK1NUM_20050	COG0714	Associated with various cellular activities
SK1NUM_20060	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SK1NUM_20070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SK1NUM_20080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SK1NUM_20090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SK1NUM_20110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SK1NUM_20160	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SK1NUM_20170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SK1NUM_20190	COG2835	tetraacyldisaccharide 4'-kinase activity
SK1NUM_20300	COG1316	TRANSCRIPTIONal
SK1NUM_20320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SK1NUM_20360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SK1NUM_20380	COG0424	maF-like protein
SK1NUM_20440	COG4770	biotin carboxylase activity
SK1NUM_20450	COG1045	serine acetyltransferase
SK1NUM_20520	COG1609	Transcriptional regulator
SK1NUM_20530	COG1070	Carbohydrate kinase
SK1NUM_20560	COG1172	Belongs to the binding-protein-dependent transport system permease family
SK1NUM_20580	COG0191	fructose-bisphosphate aldolase activity
SK1NUM_20650	COG1704	LemA family
SK1NUM_20660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SK1NUM_20670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SK1NUM_20700	COG0515	serine threonine protein kinase
SK1NUM_20700	COG2815	serine threonine protein kinase
SK1NUM_20720	COG0631	protein serine/threonine phosphatase activity
SK1NUM_20780	COG0714	Associated with various cellular activities
SK1NUM_20820	COG2319	Wd-40 repeat
SK1NUM_20820	COG4249	Peptidase C14 caspase catalytic subunit p20
SK1NUM_20830	COG0534	Mate efflux family protein
SK1NUM_20840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SK1NUM_20850	COG1113	amino acid transport
SK1NUM_20880	COG5012	cobalamin binding
SK1NUM_20950	COG0542	response to heat
SK1NUM_20960	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SK1NUM_21000	COG1404	Belongs to the peptidase S8 family
SK1NUM_21030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SK1NUM_21030	COG0351	phosphomethylpyrimidine kinase
SK1NUM_21030	COG0352	thiamine-phosphate diphosphorylase activity
SK1NUM_21040	COG0351	phosphomethylpyrimidine kinase
SK1NUM_21050	COG0352	thiamine-phosphate diphosphorylase activity
SK1NUM_21050	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SK1NUM_21050	COG0351	phosphomethylpyrimidine kinase
SK1NUM_21070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_21080	COG1120	ATPase activity
SK1NUM_21090	COG0574	Belongs to the PEP-utilizing enzyme family
SK1NUM_21090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SK1NUM_21120	COG1404	Belongs to the peptidase S8 family
SK1NUM_21240	COG4721	ABC-type cobalt transport system, permease component
SK1NUM_21260	COG0728	peptidoglycan biosynthetic process
SK1NUM_21270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SK1NUM_21280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SK1NUM_21380	COG3942	CHAP domain
SK1NUM_21420	COG0358	DNA primase activity
SK1NUM_21520	COG1192	Involved in chromosome partitioning
SK1NUM_21530	COG4974	Belongs to the 'phage' integrase family
SK1NUM_21600	COG1309	transcriptional regulator
SK1NUM_21610	COG2986	histidine ammonia-lyase
SK1NUM_21630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SK1NUM_21760	COG0314	molybdopterin synthase activity
SK1NUM_21770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SK1NUM_21820	COG1120	ATPase activity
SK1NUM_21890	COG0746	molybdenum cofactor guanylyltransferase activity
SK1NUM_21920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SK1NUM_21960	COG1140	nitrate reductase beta subunit
SK1NUM_22010	COG0431	NADPH-dependent FMN reductase
SK1NUM_22020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SK1NUM_22030	COG1120	ATPase activity
SK1NUM_22040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SK1NUM_22050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_22060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_22070	COG3048	D-serine ammonia-lyase activity
SK1NUM_22080	COG3237	CsbD-like
SK1NUM_22090	COG1472	Belongs to the glycosyl hydrolase 3 family
SK1NUM_22100	COG3254	rhamnose metabolic process
SK1NUM_22120	COG1174	glycine betaine transport
SK1NUM_22130	COG1174	glycine betaine transport
SK1NUM_22140	COG0517	IMP dehydrogenase activity
SK1NUM_22140	COG1125	glycine betaine transport
SK1NUM_22160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SK1NUM_22170	COG1321	iron dependent repressor
SK1NUM_22200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SK1NUM_22250	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SK1NUM_22270	COG2252	PERMEase
SK1NUM_22290	COG1278	Cold shock
SK1NUM_22300	COG0363	glucosamine-6-phosphate deaminase activity
SK1NUM_22320	COG0494	nUDIX hydrolase
SK1NUM_22330	COG3142	Participates in the control of copper homeostasis
SK1NUM_22340	COG1132	(ABC) transporter
SK1NUM_22350	COG1132	(ABC) transporter
SK1NUM_22350	COG2375	cellular response to nickel ion
SK1NUM_22400	COG0275	rRNA processing
SK1NUM_22420	COG3842	ATPase activity
SK1NUM_22440	COG0626	cystathionine gamma-synthase activity
SK1NUM_22450	COG1882	Formate acetyltransferase
SK1NUM_22470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SK1NUM_22480	COG3093	addiction module antidote protein HigA
SK1NUM_22510	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SK1NUM_22530	COG4303	Ethanolamine ammonia lyase large subunit
SK1NUM_22540	COG4302	ethanolamine ammonia-lyase activity
SK1NUM_22550	COG1802	Transcriptional regulator
SK1NUM_22580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SK1NUM_22600	COG1115	amino acid carrier protein
SK1NUM_22610	COG1454	alcohol dehydrogenase
SK1NUM_22640	COG0444	Belongs to the ABC transporter superfamily
SK1NUM_22650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SK1NUM_22660	COG0601	transmembrane transport
SK1NUM_22680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SK1NUM_22710	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_22800	COG1201	RNA secondary structure unwinding
SK1NUM_22820	COG3541	Predicted nucleotidyltransferase
SK1NUM_22860	COG0215	cysteine-tRNA ligase activity
SK1NUM_22880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SK1NUM_22940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SK1NUM_22950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SK1NUM_22960	COG1329	Transcriptional regulator
SK1NUM_22970	COG0745	RESPONSE REGULATOR receiver
SK1NUM_22980	COG5002	protein histidine kinase activity
SK1NUM_22990	COG0704	Plays a role in the regulation of phosphate uptake
SK1NUM_23010	COG0726	polysaccharide deacetylase
SK1NUM_23020	COG0588	phosphoglycerate mutase activity
SK1NUM_23030	COG0038	chloride channel
SK1NUM_23160	COG1472	Belongs to the glycosyl hydrolase 3 family
SK1NUM_23300	COG1028	Short-chain dehydrogenase reductase Sdr
SK1NUM_23320	COG0022	dehydrogenase e1 component
SK1NUM_23330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SK1NUM_23340	COG0508	dehydrogenase complex catalyzes the overall conversion of
SK1NUM_23350	COG1349	DNA-binding transcription factor activity
SK1NUM_23410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SK1NUM_23450	COG1203	CRISPR-associated helicase, Cas3
SK1NUM_23470	COG1518	maintenance of DNA repeat elements
SK1NUM_23470	COG1468	defense response to virus
SK1NUM_23480	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SK1NUM_23500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SK1NUM_23550	COG4191	Histidine kinase
SK1NUM_23560	COG0745	RESPONSE REGULATOR receiver
SK1NUM_23700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SK1NUM_23710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SK1NUM_23710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SK1NUM_23760	COG0148	phosphopyruvate hydratase activity
SK1NUM_23780	COG2304	oxidoreductase activity
SK1NUM_23830	COG0193	aminoacyl-tRNA hydrolase activity
SK1NUM_23840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SK1NUM_23890	COG2094	Belongs to the DNA glycosylase MPG family
SK1NUM_23910	COG1131	(ABC) transporter
SK1NUM_23930	COG0577	efflux transmembrane transporter activity
SK1NUM_23940	COG0577	efflux transmembrane transporter activity
SK1NUM_23940	COG1136	(ABC) transporter
SK1NUM_23970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SK1NUM_23980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SK1NUM_24000	COG0519	Catalyzes the synthesis of GMP from XMP
SK1NUM_24030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SK1NUM_24040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SK1NUM_24050	COG0084	hydrolase, TatD family'
SK1NUM_24100	COG2233	PERMEase
SK1NUM_24110	COG0133	tryptophan synthase activity
SK1NUM_24130	COG0604	alcohol dehydrogenase
SK1NUM_24130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SK1NUM_24130	COG3321	synthase
SK1NUM_24130	COG4221	oxidoreductase activity
SK1NUM_24170	COG1309	transcriptional regulator
SK1NUM_24180	COG2814	Major facilitator Superfamily
SK1NUM_24200	COG1063	alcohol dehydrogenase
SK1NUM_24220	COG0667	Aldo Keto reductase
SK1NUM_24250	COG0477	Major facilitator Superfamily
SK1NUM_24290	COG2205	protein histidine kinase activity
SK1NUM_24300	COG0745	RESPONSE REGULATOR receiver
SK1NUM_24310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SK1NUM_24310	COG0785	Cytochrome C biogenesis protein
SK1NUM_24400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SK1NUM_24420	COG1090	epimerase
SK1NUM_24460	COG0747	negative chemotaxis
SK1NUM_24630	COG1970	mechanosensitive ion channel activity
SK1NUM_24660	COG0673	inositol 2-dehydrogenase activity
SK1NUM_24680	COG1175	transmembrane transport
SK1NUM_24690	COG0395	ABC-type sugar transport system, permease component
SK1NUM_24740	COG0281	malic enzyme
SK1NUM_24850	COG1309	transcriptional regulator
SK1NUM_24860	COG0477	Major facilitator Superfamily
SK1NUM_24930	COG1733	regulation of RNA biosynthetic process
SK1NUM_24980	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
SK1NUM_25020	COG0012	GTP binding
SK1NUM_25030	COG1362	aminopeptidase activity
SK1NUM_25080	COG0464	growth
SK1NUM_25120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SK1NUM_25150	COG1570	exodeoxyribonuclease VII activity
SK1NUM_25160	COG1722	exodeoxyribonuclease VII activity
SK1NUM_25190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SK1NUM_25210	COG1774	PSP1 C-terminal conserved region
SK1NUM_25230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SK1NUM_25240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SK1NUM_25260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SK1NUM_25260	COG1754	DNA topoisomerase type I activity
SK1NUM_25290	COG1940	carbohydrate kinase activity
SK1NUM_25300	COG1136	(ABC) transporter
SK1NUM_25320	COG0577	efflux transmembrane transporter activity
SK1NUM_25330	COG0018	arginyl-trna synthetase
SK1NUM_25340	COG0656	L-ascorbic acid biosynthetic process
SK1NUM_25350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SK1NUM_25420	COG1716	ATPase activity
SK1NUM_25450	COG0768	penicillin binding
SK1NUM_25460	COG0515	serine threonine protein kinase
SK1NUM_25550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SK1NUM_25580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SK1NUM_25600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_25610	COG1120	ATPase activity
SK1NUM_25750	COG2197	response regulator
SK1NUM_25780	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SK1NUM_25820	COG2184	nucleotidyltransferase activity
SK1NUM_25860	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SK1NUM_25870	COG1468	defense response to virus
SK1NUM_25870	COG1518	maintenance of DNA repeat elements
SK1NUM_25880	COG1468	defense response to virus
SK1NUM_25880	COG1518	maintenance of DNA repeat elements
SK1NUM_25980	COG3263	regulation of cellular component size
SK1NUM_26040	COG0438	transferase activity, transferring glycosyl groups
SK1NUM_26050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SK1NUM_26060	COG0037	tRNA processing
SK1NUM_26080	COG2027	D-alanyl-D-alanine carboxypeptidase
SK1NUM_26090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SK1NUM_26240	COG1252	NADH dehydrogenase
SK1NUM_26270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SK1NUM_26310	COG2259	Doxx family
SK1NUM_26350	COG0745	RESPONSE REGULATOR receiver
SK1NUM_26360	COG2205	protein histidine kinase activity
SK1NUM_26380	COG3739	integral membrane protein
SK1NUM_26390	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SK1NUM_26400	COG1132	(ABC) transporter
SK1NUM_26410	COG1132	(ABC) transporter
SK1NUM_26420	COG2375	cellular response to nickel ion
SK1NUM_26420	COG1132	(ABC) transporter
SK1NUM_26450	COG1136	(ABC) transporter
SK1NUM_26470	COG2826	transposase and inactivated derivatives, IS30 family
SK1NUM_26550	COG0717	Belongs to the dCTP deaminase family
SK1NUM_26570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SK1NUM_26610	COG1960	acyl-CoA dehydrogenase activity
SK1NUM_26620	COG3321	synthase
SK1NUM_26640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SK1NUM_26680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SK1NUM_26690	COG0156	8-amino-7-oxononanoate synthase activity
SK1NUM_26700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SK1NUM_26770	COG1012	belongs to the aldehyde dehydrogenase family
SK1NUM_26810	COG1131	(ABC) transporter
SK1NUM_26890	COG3022	response to hydroperoxide
SK1NUM_26900	COG2249	NAD(P)H dehydrogenase (quinone) activity
SK1NUM_26920	COG1131	(ABC) transporter
SK1NUM_26980	COG0789	Transcriptional regulator
SK1NUM_27040	COG0673	inositol 2-dehydrogenase activity
SK1NUM_27120	COG1120	ATPase activity
SK1NUM_27220	COG0433	COG0433 Predicted ATPase
SK1NUM_27270	COG1304	FMN binding
SK1NUM_27320	COG1113	amino acid transport
SK1NUM_27380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SK1NUM_27450	COG1674	ftsk spoiiie
SK1NUM_27530	COG0714	Associated with various cellular activities
SK1NUM_27560	COG0584	glycerophosphoryl diester phosphodiesterase
SK1NUM_27680	COG2340	Cysteine-rich secretory protein family
SK1NUM_27690	COG0745	RESPONSE REGULATOR receiver
SK1NUM_27700	COG5002	protein histidine kinase activity
SK1NUM_27710	COG0577	efflux transmembrane transporter activity
SK1NUM_27710	COG1136	(ABC) transporter
SK1NUM_27750	COG1132	(ABC) transporter
SK1NUM_27760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SK1NUM_27840	COG1401	restriction endodeoxyribonuclease activity
SK1NUM_27860	COG4804	nuclease activity
SK1NUM_27870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SK1NUM_27880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SK1NUM_27890	COG1205	dead DEAH box helicase
SK1NUM_27890	COG1111	helicase
SK1NUM_27950	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
SK1NUM_28050	COG1129	ABC transporter
SK1NUM_28120	COG0564	pseudouridine synthase activity
SK1NUM_28210	COG3321	synthase
SK1NUM_28210	COG0604	alcohol dehydrogenase
SK1NUM_28210	COG1028	Short-chain dehydrogenase reductase Sdr
SK1NUM_28220	COG0137	argininosuccinate synthase activity
SK1NUM_28240	COG1216	Glycosyl transferase, family 2
SK1NUM_28270	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SK1NUM_28290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SK1NUM_28310	COG1129	ABC transporter
SK1NUM_28350	COG4917	ethanolamine utilization protein
SK1NUM_28440	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SK1NUM_28500	COG0039	L-malate dehydrogenase activity
SK1NUM_28610	COG0442	prolyl-tRNA aminoacylation
SK1NUM_28760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SK1NUM_28770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SK1NUM_28780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SK1NUM_28790	COG1696	Membrane protein involved in D-alanine export
SK1NUM_28810	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SK1NUM_28880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SK1NUM_28910	COG0733	neurotransmitter:sodium symporter activity
SK1NUM_28940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SK1NUM_28950	COG1408	metallophosphoesterase
SK1NUM_28990	COG3012	SEC-C Motif Domain Protein
SK1NUM_29130	COG1051	belongs to the nudix hydrolase family
SK1NUM_29140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SK1NUM_29170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SK1NUM_29190	COG0653	protein targeting
SK1NUM_29220	COG0315	cyclic pyranopterin monophosphate synthase activity
SK1NUM_29220	COG0521	Mo-molybdopterin cofactor biosynthetic process
SK1NUM_29290	COG4139	cobalamin transport
SK1NUM_29300	COG1120	ATPase activity
SK1NUM_29340	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SK1NUM_29360	COG3177	Filamentation induced by cAMP protein fic
SK1NUM_29400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SK1NUM_29420	COG0457	Tetratricopeptide repeat
SK1NUM_29420	COG0705	Rhomboid family
SK1NUM_29430	COG0768	penicillin binding
SK1NUM_29500	COG1309	transcriptional regulator
SK1NUM_29520	COG2184	nucleotidyltransferase activity
SK1NUM_29600	COG1120	ATPase activity
SK1NUM_29610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SK1NUM_29630	COG0783	Belongs to the Dps family
SK1NUM_29820	COG1971	Probably functions as a manganese efflux pump
SK1NUM_29830	COG2390	Transcriptional regulator
SK1NUM_29860	COG1505	serine-type exopeptidase activity
SK1NUM_29900	COG0492	ferredoxin-NADP+ reductase activity
SK1NUM_29940	COG1181	Belongs to the D-alanine--D-alanine ligase family
SK1NUM_29960	COG1192	Involved in chromosome partitioning
SK1NUM_29970	COG0357	Ribosomal RNA small subunit methyltransferase G
SK1NUM_29990	COG0706	membrane insertase activity
SK1NUM_30000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SK1NUM_30010	COG0594	ribonuclease P activity
SK1NUM_30020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SK1NUM_30030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SK1NUM_30040	COG0592	DNA-directed DNA polymerase activity
SK1NUM_30060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SK1NUM_30090	COG0187	DNA topoisomerase II activity
SK1NUM_30100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SK1NUM_30120	COG0747	negative chemotaxis
SK1NUM_30140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SK1NUM_30170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SK1NUM_30180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SK1NUM_30190	COG1121	(ABC) transporter
SK1NUM_30200	COG0803	Belongs to the bacterial solute-binding protein 9 family
SK1NUM_30240	COG0501	Belongs to the peptidase M48B family