locus-tag	class	description
Arch_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Arch_0002	COG0592	DNA-directed DNA polymerase activity
Arch_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Arch_0005	COG0187	DNA topoisomerase II activity
Arch_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Arch_0014	COG1846	Transcriptional regulator
Arch_0014	COG1940	carbohydrate kinase activity
Arch_0015	COG0786	glutamate:sodium symporter activity
Arch_0019	COG1620	l-lactate permease
Arch_0020	COG0247	lactate metabolic process
Arch_0021	COG1139	Iron-sulfur cluster binding protein
Arch_0022	COG1556	Lactate utilization protein
Arch_0028	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Arch_0035	COG1609	Transcriptional regulator
Arch_0039	COG2814	Major facilitator Superfamily
Arch_0041	COG1082	Xylose isomerase domain protein TIM barrel
Arch_0042	COG0673	inositol 2-dehydrogenase activity
Arch_0043	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Arch_0045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Arch_0047	COG3718	enzyme involved in inositol metabolism
Arch_0048	COG3962	Belongs to the TPP enzyme family
Arch_0051	COG1940	carbohydrate kinase activity
Arch_0053	COG0601	transmembrane transport
Arch_0054	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Arch_0056	COG1940	carbohydrate kinase activity
Arch_0060	COG0584	glycerophosphoryl diester phosphodiesterase
Arch_0067	COG1088	dTDP-glucose 4,6-dehydratase activity
Arch_0076	COG0463	Glycosyl transferase, family 2
Arch_0080	COG1216	Glycosyl transferase, family 2
Arch_0080	COG1442	glycosyl transferase family 8
Arch_0081	COG3475	LICD family
Arch_0082	COG0697	spore germination
Arch_0083	COG4750	Nucleotidyl transferase
Arch_0084	COG0438	transferase activity, transferring glycosyl groups
Arch_0089	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Arch_0094	COG0697	spore germination
Arch_0097	COG0705	Rhomboid family
Arch_0099	COG3764	Sortase (surface protein transpeptidase)
Arch_0101	COG3547	Transposase (IS116 IS110 IS902 family)
Arch_0103	COG0768	penicillin binding
Arch_0106	COG1716	ATPase activity
Arch_0107	COG0842	Transport permease protein
Arch_0107	COG1716	ATPase activity
Arch_0107	COG1131	(ABC) transporter
Arch_0108	COG2860	membrane
Arch_0110	COG0328	RNA-DNA hybrid ribonuclease activity
Arch_0113	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Arch_0114	COG1854	S-ribosylhomocysteine lyase activity
Arch_0116	COG1780	Probably involved in ribonucleotide reductase function
Arch_0117	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Arch_0125	COG0765	amino acid transport
Arch_0127	COG1643	Atp-dependent helicase
Arch_0130	COG2188	Transcriptional regulator
Arch_0136	COG0586	Pfam SNARE associated Golgi protein
Arch_0137	COG1950	PFAM Membrane protein of
Arch_0140	COG0710	3-dehydroquinate dehydratase activity
Arch_0141	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Arch_0142	COG0803	Belongs to the bacterial solute-binding protein 9 family
Arch_0143	COG1121	(ABC) transporter
Arch_0144	COG1321	iron dependent repressor
Arch_0144	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Arch_0145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Arch_0146	COG1321	iron dependent repressor
Arch_0147	COG0717	Belongs to the dCTP deaminase family
Arch_0148	COG2111	Na H antiporter
Arch_0148	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Arch_0153	COG1320	monovalent cation:proton antiporter activity
Arch_0155	COG1840	ABC-type Fe3 transport system, periplasmic component
Arch_0157	COG3842	ATPase activity
Arch_0159	COG0395	ABC-type sugar transport system, permease component
Arch_0160	COG4209	transmembrane transport
Arch_0161	COG1653	transport
Arch_0163	COG2814	Major facilitator Superfamily
Arch_0166	COG0662	Cupin 2, conserved barrel domain protein
Arch_0167	COG1505	serine-type exopeptidase activity
Arch_0168	COG0443	Heat shock 70 kDa protein
Arch_0169	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Arch_0170	COG0484	heat shock protein binding
Arch_0171	COG0789	Transcriptional regulator
Arch_0172	COG0494	nUDIX hydrolase
Arch_0175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Arch_0178	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Arch_0181	COG1113	amino acid transport
Arch_0182	COG1260	myo-inositol-1-phosphate synthase
Arch_0185	COG0300	oxidoreductase activity
Arch_0187	COG0494	nUDIX hydrolase
Arch_0192	COG0191	fructose-bisphosphate aldolase activity
Arch_0195	COG1175	transmembrane transport
Arch_0200	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Arch_0201	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Arch_0202	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Arch_0211	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Arch_0218	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Arch_0219	COG0306	phosphate transporter
Arch_0221	COG1115	amino acid carrier protein
Arch_0224	COG4044	May play a role in the intracellular transport of hydrophobic ligands
Arch_0225	COG0354	folic acid binding
Arch_0226	COG1490	D-aminoacyl-tRNA deacylase activity
Arch_0227	COG0542	response to heat
Arch_0232	COG3547	Transposase (IS116 IS110 IS902 family)
Arch_0238	COG2056	Na+-H+ antiporter family
Arch_0240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Arch_0240	COG0574	Belongs to the PEP-utilizing enzyme family
Arch_0241	COG2755	lipolytic protein G-D-S-L family
Arch_0241	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Arch_0246	COG0791	NLP P60 protein
Arch_0247	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Arch_0248	COG2027	D-alanyl-D-alanine carboxypeptidase
Arch_0250	COG0037	tRNA processing
Arch_0251	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Arch_0252	COG0302	gtp cyclohydrolase
Arch_0254	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Arch_0259	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Arch_0260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Arch_0261	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Arch_0262	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Arch_0263	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Arch_0265	COG0247	lactate metabolic process
Arch_0266	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
Arch_0267	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Arch_0269	COG1194	a g-specific adenine glycosylase
Arch_0271	COG0477	Major facilitator Superfamily
Arch_0272	COG0477	Major facilitator Superfamily
Arch_0273	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Arch_0276	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Arch_0277	COG0569	domain protein
Arch_0278	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Arch_0281	COG0406	alpha-ribazole phosphatase activity
Arch_0285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Arch_0287	COG4948	Mandelate Racemase Muconate Lactonizing
Arch_0288	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Arch_0289	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Arch_0291	COG2226	methyltransferase
Arch_0292	COG0644	oxidoreductase
Arch_0294	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Arch_0295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Arch_0296	COG0649	NAD binding
Arch_0298	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Arch_0299	COG1034	ATP synthesis coupled electron transport
Arch_0300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Arch_0303	COG0713	ATP synthesis coupled electron transport
Arch_0306	COG1007	ATP synthesis coupled electron transport
Arch_0308	COG0653	protein targeting
Arch_0309	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Arch_0311	COG4691	Plasmid stability protein
Arch_0319	COG0419	ATPase involved in DNA repair
Arch_0320	COG0420	3'-5' exonuclease activity
Arch_0326	COG1162	GTPase activity
Arch_0327	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Arch_0331	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Arch_0332	COG0363	glucosamine-6-phosphate deaminase activity
Arch_0333	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Arch_0334	COG1595	DNA-templated transcription, initiation
Arch_0346	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arch_0346	COG0567	Dehydrogenase, E1 component
Arch_0347	COG1253	flavin adenine dinucleotide binding
Arch_0349	COG0739	heme binding
Arch_0350	COG0584	glycerophosphoryl diester phosphodiesterase
Arch_0351	COG0018	arginyl-trna synthetase
Arch_0355	COG0254	rRNA binding
Arch_0356	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Arch_0358	COG0009	L-threonylcarbamoyladenylate synthase
Arch_0359	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Arch_0361	COG0356	it plays a direct role in the translocation of protons across the membrane
Arch_0362	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Arch_0363	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Arch_0364	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Arch_0365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Arch_0366	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Arch_0367	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Arch_0368	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Arch_0370	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Arch_0377	COG0366	Alpha amylase catalytic
Arch_0381	COG3833	ABC-type maltose transport systems, permease component
Arch_0382	COG0431	NADPH-dependent FMN reductase
Arch_0383	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Arch_0384	COG3281	Trehalose synthase
Arch_0386	COG0366	Alpha amylase catalytic
Arch_0388	COG0058	SHG alpha-glucan phosphorylase activity
Arch_0389	COG0180	Tryptophanyl-tRNA synthetase
Arch_0396	COG3480	Lon protease (S16) C-terminal proteolytic domain
Arch_0398	COG1615	UPF0182 protein
Arch_0400	COG1131	(ABC) transporter
Arch_0401	COG1725	Transcriptional regulator
Arch_0409	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Arch_0415	COG2197	response regulator
Arch_0417	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Arch_0419	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Arch_0420	COG0154	amidase activity
Arch_0421	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Arch_0424	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Arch_0427	COG2985	domain, Protein
Arch_0427	COG0569	domain protein
Arch_0428	COG1027	Aspartate ammonia-lyase
Arch_0430	COG1882	Formate acetyltransferase
Arch_0433	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Arch_0435	COG1609	Transcriptional regulator
Arch_0436	COG1904	glucuronate isomerase
Arch_0437	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Arch_0438	COG0800	Aldolase
Arch_0439	COG1312	Catalyzes the dehydration of D-mannonate
Arch_0444	COG0577	efflux transmembrane transporter activity
Arch_0444	COG1136	(ABC) transporter
Arch_0450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Arch_0467	COG4115	mRNA cleavage
Arch_0468	COG1946	Acyl-CoA thioesterase
Arch_0472	COG2116	formate transmembrane transporter activity
Arch_0474	COG3590	peptidase
Arch_0476	COG1045	serine acetyltransferase
Arch_0478	COG1739	Uncharacterized protein family UPF0029
Arch_0482	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Arch_0483	COG1121	(ABC) transporter
Arch_0486	COG1966	Carbon starvation protein
Arch_0491	COG1428	Deoxynucleoside kinase
Arch_0493	COG0521	Mo-molybdopterin cofactor biosynthetic process
Arch_0494	COG1653	transport
Arch_0496	COG0395	ABC-type sugar transport system, permease component
Arch_0513	COG3409	Peptidoglycan-binding domain 1 protein
Arch_0517	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Arch_0521	COG4626	Terminase
Arch_0521	COG1802	Transcriptional regulator
Arch_0523	COG4695	Portal protein
Arch_0526	COG2197	response regulator
Arch_0529	COG2197	response regulator
Arch_0536	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Arch_0537	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Arch_0539	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Arch_0540	COG0544	peptidyl-prolyl cis-trans isomerase activity
Arch_0541	COG0740	serine-type endopeptidase activity
Arch_0542	COG0740	serine-type endopeptidase activity
Arch_0543	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Arch_0544	COG1609	Transcriptional regulator
Arch_0545	COG2271	Major facilitator Superfamily
Arch_0546	COG0483	inositol monophosphate 1-phosphatase activity
Arch_0547	COG1022	Amp-dependent synthetase and ligase
Arch_0551	COG1132	(ABC) transporter
Arch_0552	COG1132	(ABC) transporter
Arch_0553	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Arch_0554	COG0285	dihydrofolate synthase activity
Arch_0555	COG0105	UTP biosynthetic process
Arch_0556	COG1461	Dihydroxyacetone kinase
Arch_0567	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Arch_0569	COG1837	Belongs to the UPF0109 family
Arch_0570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Arch_0571	COG0336	Belongs to the RNA methyltransferase TrmD family
Arch_0572	COG0335	large ribosomal subunit rRNA binding
Arch_0573	COG0681	Belongs to the peptidase S26 family
Arch_0574	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Arch_0576	COG0792	nuclease activity
Arch_0577	COG0606	chelatase, subunit chli
Arch_0579	COG4974	Belongs to the 'phage' integrase family
Arch_0580	COG1404	Belongs to the peptidase S8 family
Arch_0583	COG0052	Belongs to the universal ribosomal protein uS2 family
Arch_0584	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Arch_0586	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Arch_0587	COG0644	oxidoreductase
Arch_0589	COG1113	amino acid transport
Arch_0599	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Arch_0601	COG0233	cytoplasmic translational termination
Arch_0603	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Arch_0605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Arch_0606	COG0750	zinc metalloprotease
Arch_0607	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Arch_0609	COG0442	prolyl-tRNA aminoacylation
Arch_0611	COG0779	Required for maturation of 30S ribosomal subunits
Arch_0614	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Arch_0615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Arch_0616	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Arch_0625	COG0577	efflux transmembrane transporter activity
Arch_0625	COG1136	(ABC) transporter
Arch_0627	COG1122	ATPase activity
Arch_0630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Arch_0631	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Arch_0633	COG1185	polyribonucleotide nucleotidyltransferase activity
Arch_0637	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Arch_0638	COG3842	ATPase activity
Arch_0640	COG1840	ABC-type Fe3 transport system, periplasmic component
Arch_0642	COG5002	protein histidine kinase activity
Arch_0643	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Arch_0644	COG1674	ftsk spoiiie
Arch_0646	COG1546	Belongs to the CinA family
Arch_0646	COG1058	Belongs to the CinA family
Arch_0647	COG1396	sequence-specific DNA binding
Arch_0650	COG2137	regulation of response to DNA damage stimulus
Arch_0651	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Arch_0652	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Arch_0653	COG1064	alcohol dehydrogenase
Arch_0654	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Arch_0656	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Arch_0658	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Arch_0659	COG0318	PFAM AMP-dependent synthetase and ligase
Arch_0663	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Arch_0665	COG2001	Belongs to the MraZ family
Arch_0666	COG0275	rRNA processing
Arch_0668	COG0768	penicillin binding
Arch_0669	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Arch_0671	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Arch_0672	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Arch_0675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Arch_0677	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Arch_0679	COG1799	cell septum assembly
Arch_0682	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Arch_0688	COG0735	belongs to the Fur family
Arch_0689	COG1321	iron dependent repressor
Arch_0689	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Arch_0690	COG1121	(ABC) transporter
Arch_0692	COG0423	glycine-tRNA ligase activity
Arch_0697	COG1879	ABC-type sugar transport system periplasmic component
Arch_0698	COG1129	ABC transporter
Arch_0699	COG4211	Belongs to the binding-protein-dependent transport system permease family
Arch_0701	COG0358	DNA primase activity
Arch_0714	COG0009	L-threonylcarbamoyladenylate synthase
Arch_0718	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Arch_0723	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Arch_0725	COG3022	response to hydroperoxide
Arch_0728	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Arch_0729	COG0174	glutamine synthetase
Arch_0730	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Arch_0732	COG0174	glutamine synthetase
Arch_0735	COG0508	dehydrogenase complex catalyzes the overall conversion of
Arch_0736	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Arch_0738	COG1120	ATPase activity
Arch_0739	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Arch_0741	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Arch_0742	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Arch_0744	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Arch_0752	COG0205	6-phosphofructokinase activity
Arch_0753	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Arch_0754	COG2815	serine threonine protein kinase
Arch_0754	COG0515	serine threonine protein kinase
Arch_0755	COG1388	LysM domain
Arch_0760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Arch_0761	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Arch_0763	COG0187	DNA topoisomerase II activity
Arch_0766	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Arch_0769	COG1435	thymidine kinase activity
Arch_0776	COG0569	domain protein
Arch_0782	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Arch_0785	COG2963	transposase activity
Arch_0789	COG1136	(ABC) transporter
Arch_0791	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Arch_0792	COG2963	transposase activity
Arch_0796	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Arch_0804	COG0730	response to heat
Arch_0809	COG0803	Belongs to the bacterial solute-binding protein 9 family
Arch_0810	COG1121	(ABC) transporter
Arch_0811	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Arch_0812	COG1760	l-serine dehydratase
Arch_0813	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Arch_0816	COG0438	transferase activity, transferring glycosyl groups
Arch_0819	COG0494	nUDIX hydrolase
Arch_0820	COG0217	transcriptional regulatory protein
Arch_0821	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Arch_0822	COG0632	four-way junction helicase activity
Arch_0823	COG2255	four-way junction helicase activity
Arch_0825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Arch_0826	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Arch_0827	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Arch_0828	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Arch_0830	COG1196	nuclear chromosome segregation
Arch_0832	COG0124	histidyl-tRNA synthetase
Arch_0834	COG1160	GTP binding
Arch_0837	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Arch_0839	COG2409	Drug exporters of the RND superfamily
Arch_0841	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Arch_0842	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Arch_0843	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Arch_0847	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Arch_0850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Arch_0851	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Arch_0852	COG0194	GDP metabolic process
Arch_0853	COG0194	GDP metabolic process
Arch_0854	COG1758	RNA polymerase activity
Arch_0856	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Arch_0858	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Arch_0860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Arch_0861	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Arch_0862	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Arch_0873	COG1160	GTP binding
Arch_0874	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Arch_0876	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Arch_0879	COG4974	Belongs to the 'phage' integrase family
Arch_0881	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Arch_0882	COG0149	triose-phosphate isomerase activity
Arch_0883	COG0126	phosphoglycerate kinase activity
Arch_0884	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Arch_0885	COG1481	regulation of sporulation
Arch_0887	COG1660	Displays ATPase and GTPase activities
Arch_0891	COG0861	Integral membrane protein TerC family
Arch_0892	COG0556	nucleotide-excision repair
Arch_0893	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Arch_0893	COG0237	dephospho-CoA kinase activity
Arch_0894	COG0539	negative regulation of cytoplasmic translation
Arch_0899	COG0469	pyruvate kinase activity
Arch_0900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Arch_0902	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Arch_0904	COG4122	O-methyltransferase activity
Arch_0905	COG1222	aaa ATPase
Arch_0909	COG1968	undecaprenyl-diphosphatase activity
Arch_0910	COG0667	Aldo Keto reductase
Arch_0913	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Arch_0914	COG0222	ribosome binding
Arch_0921	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Arch_0926	COG1119	ATPase activity
Arch_0927	COG0297	glycogen (starch) synthase activity
Arch_0929	COG0488	(ABC) transporter
Arch_0931	COG2151	metal-sulfur cluster biosynthetic enzyme
Arch_0932	COG0822	iron-sulfur transferase activity
Arch_0933	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Arch_0934	COG0396	ATPase activity
Arch_0936	COG0719	Fe-S assembly protein
Arch_0940	COG0728	peptidoglycan biosynthetic process
Arch_0948	COG0647	UMP catabolic process
Arch_0950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Arch_0951	COG3949	Membrane
Arch_0952	COG0778	Nitroreductase
Arch_0954	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Arch_0955	COG0300	oxidoreductase activity
Arch_0957	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Arch_0960	COG4608	Belongs to the ABC transporter superfamily
Arch_0961	COG0444	Belongs to the ABC transporter superfamily
Arch_0964	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Arch_0965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Arch_0966	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Arch_0971	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Arch_0972	COG1381	Involved in DNA repair and RecF pathway recombination
Arch_0973	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Arch_0975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Arch_0977	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Arch_0978	COG0484	heat shock protein binding
Arch_0979	COG1420	regulation of RNA biosynthetic process
Arch_0987	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Arch_0988	COG0481	GTPase activity
Arch_0992	COG0268	Binds directly to 16S ribosomal RNA
Arch_0993	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Arch_0994	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Arch_0997	COG1596	polysaccharide export
Arch_0997	COG1555	photosystem II stabilization
Arch_0998	COG0433	COG0433 Predicted ATPase
Arch_1000	COG0495	leucyl-tRNA aminoacylation
Arch_1005	COG0813	purine-nucleoside phosphorylase activity
Arch_1006	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Arch_1007	COG2011	ABC-type metal ion transport system permease component
Arch_1010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Arch_1012	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Arch_1013	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Arch_1014	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Arch_1018	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Arch_1018	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Arch_1019	COG0540	Belongs to the ATCase OTCase family
Arch_1020	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Arch_1022	COG0167	dihydroorotate dehydrogenase activity
Arch_1023	COG0543	2 iron, 2 sulfur cluster binding
Arch_1025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Arch_1028	COG1757	Na H antiporter
Arch_1029	COG0254	rRNA binding
Arch_1031	COG0477	Major facilitator Superfamily
Arch_1033	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Arch_1034	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Arch_1036	COG0659	secondary active sulfate transmembrane transporter activity
Arch_1041	COG3547	Transposase (IS116 IS110 IS902 family)
Arch_1052	COG0732	type I restriction modification DNA specificity domain
Arch_1059	COG2226	methyltransferase
Arch_1063	COG0406	alpha-ribazole phosphatase activity
Arch_1064	COG0799	negative regulation of ribosome biogenesis
Arch_1066	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Arch_1067	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Arch_1069	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Arch_1070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Arch_1071	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Arch_1072	COG1530	ribonuclease E activity
Arch_1073	COG1271	oxidase subunit
Arch_1074	COG1294	oxidase, subunit
Arch_1075	COG4988	ABC transporter
Arch_1076	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Arch_1079	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Arch_1080	COG0571	ribonuclease III activity
Arch_1083	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Arch_1084	COG0742	ribosomal rna small subunit methyltransferase
Arch_1085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Arch_1086	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Arch_1092	COG1181	Belongs to the D-alanine--D-alanine ligase family
Arch_1093	COG0204	Acyl-transferase
Arch_1094	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Arch_1096	COG0438	transferase activity, transferring glycosyl groups
Arch_1100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Arch_1109	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Arch_1110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Arch_1111	COG3177	Filamentation induced by cAMP protein fic
Arch_1113	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Arch_1115	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Arch_1120	COG2985	domain, Protein
Arch_1120	COG0569	domain protein
Arch_1121	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Arch_1122	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Arch_1122	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Arch_1122	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Arch_1123	COG2376	Dihydroxyacetone kinase
Arch_1127	COG3842	ATPase activity
Arch_1128	COG1840	ABC-type Fe3 transport system, periplasmic component
Arch_1129	COG2271	Major facilitator Superfamily
Arch_1131	COG2205	protein histidine kinase activity
Arch_1140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Arch_1141	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Arch_1142	COG1418	mRNA catabolic process
Arch_1143	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Arch_1144	COG1121	(ABC) transporter
Arch_1150	COG1131	(ABC) transporter
Arch_1153	COG0765	amino acid transport
Arch_1154	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Arch_1156	COG1114	Component of the transport system for branched-chain amino acids
Arch_1157	COG1114	Component of the transport system for branched-chain amino acids
Arch_1158	COG1114	Component of the transport system for branched-chain amino acids
Arch_1159	COG0519	Catalyzes the synthesis of GMP from XMP
Arch_1160	COG1285	pathogenesis
Arch_1164	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Arch_1171	COG1252	NADH dehydrogenase
Arch_1175	COG0165	Argininosuccinate lyase
Arch_1177	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Arch_1183	COG1129	ABC transporter
Arch_1187	COG0789	Transcriptional regulator
Arch_1195	COG2963	transposase activity
Arch_1217	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Arch_1218	COG0739	heme binding
Arch_1219	COG2177	Part of the ABC transporter FtsEX involved in
Arch_1220	COG2884	Cell division ATP-binding protein ftsE
Arch_1221	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Arch_1232	COG2354	Protein conserved in bacteria
Arch_1234	COG0513	Belongs to the DEAD box helicase family
Arch_1235	COG2095	MarC family integral membrane protein
Arch_1237	COG0006	proline dipeptidase activity
Arch_1242	COG0805	protein transport
Arch_1243	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Arch_1246	COG0315	cyclic pyranopterin monophosphate synthase activity
Arch_1251	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Arch_1255	COG0437	4 iron, 4 sulfur cluster binding
Arch_1256	COG0243	molybdopterin cofactor binding
Arch_1257	COG1309	transcriptional regulator
Arch_1263	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Arch_1275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Arch_1276	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Arch_1278	COG0351	phosphomethylpyrimidine kinase
Arch_1278	COG0352	thiamine-phosphate diphosphorylase activity
Arch_1278	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Arch_1281	COG0110	maltose O-acetyltransferase activity
Arch_1286	COG3012	SEC-C Motif Domain Protein
Arch_1287	COG0039	L-malate dehydrogenase activity
Arch_1289	COG0166	Belongs to the GPI family
Arch_1291	COG0205	6-phosphofructokinase activity
Arch_1292	COG3250	beta-galactosidase activity
Arch_1296	COG0045	succinate-CoA ligase (ADP-forming) activity
Arch_1297	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Arch_1297	COG2755	lipolytic protein G-D-S-L family
Arch_1300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Arch_1307	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Arch_1307	COG0519	Catalyzes the synthesis of GMP from XMP
Arch_1310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Arch_1315	COG0280	phosphate acetyltransferase
Arch_1315	COG0857	belongs to the CobB CobQ family
Arch_1316	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Arch_1319	COG0114	fumarate hydratase activity
Arch_1320	COG0516	GMP reductase activity
Arch_1322	COG3634	alkyl hydroperoxide reductase activity
Arch_1323	COG0450	alkyl hydroperoxide reductase
Arch_1327	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Arch_1329	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Arch_1330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Arch_1331	COG1053	succinate dehydrogenase
Arch_1336	COG0802	atpase or kinase
Arch_1337	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Arch_1338	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Arch_1339	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Arch_1340	COG1072	(Pantothenic acid kinase))
Arch_1342	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Arch_1343	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Arch_1344	COG0101	tRNA pseudouridine synthase activity
Arch_1347	COG0203	ribosomal protein L17
Arch_1348	COG0202	RNA polymerase activity
Arch_1350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Arch_1351	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Arch_1352	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Arch_1354	COG0644	oxidoreductase
Arch_1358	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Arch_1359	COG2271	Major facilitator Superfamily
Arch_1361	COG0318	PFAM AMP-dependent synthetase and ligase
Arch_1363	COG1960	acyl-CoA dehydrogenase activity
Arch_1366	COG0024	Methionine aminopeptidase
Arch_1367	COG0563	adenylate kinase activity
Arch_1368	COG0201	protein transport
Arch_1369	COG0200	Binds to the 23S rRNA
Arch_1370	COG1841	ribosomal large subunit assembly
Arch_1371	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Arch_1373	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Arch_1374	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Arch_1375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Arch_1376	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Arch_1377	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Arch_1378	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Arch_1379	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Arch_1382	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Arch_1383	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Arch_1384	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Arch_1385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Arch_1386	COG0089	rRNA binding
Arch_1387	COG0088	Forms part of the polypeptide exit tunnel
Arch_1388	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Arch_1389	COG0051	transcription antitermination factor activity, RNA binding
Arch_1390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Arch_1391	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Arch_1392	COG0049	tRNA binding
Arch_1393	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Arch_1395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Arch_1396	COG0085	RNA polymerase activity
Arch_1397	COG0222	ribosome binding
Arch_1398	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Arch_1399	COG0572	uridine kinase
Arch_1400	COG0081	regulation of translation
Arch_1401	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Arch_1404	COG0436	Aminotransferase
Arch_1406	COG3547	Transposase (IS116 IS110 IS902 family)
Arch_1408	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Arch_1411	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Arch_1412	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Arch_1413	COG1666	GTP binding
Arch_1415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Arch_1418	COG5002	protein histidine kinase activity
Arch_1419	COG0745	RESPONSE REGULATOR receiver
Arch_1426	COG1316	TRANSCRIPTIONal
Arch_1427	COG1316	TRANSCRIPTIONal
Arch_1428	COG0642	Histidine kinase
Arch_1429	COG0745	RESPONSE REGULATOR receiver
Arch_1432	COG0424	maF-like protein
Arch_1439	COG1132	(ABC) transporter
Arch_1440	COG1132	(ABC) transporter
Arch_1445	COG0321	lipoyl(octanoyl) transferase activity
Arch_1446	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Arch_1447	COG0318	PFAM AMP-dependent synthetase and ligase
Arch_1448	COG1362	aminopeptidase activity
Arch_1453	COG0039	L-malate dehydrogenase activity
Arch_1454	COG3971	2-oxopent-4-enoate hydratase activity
Arch_1457	COG2195	Cleaves the N-terminal amino acid of tripeptides
Arch_1459	COG3711	transcriptional antiterminator
Arch_1460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Arch_1461	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Arch_1462	COG0431	NADPH-dependent FMN reductase
Arch_1466	COG0783	Belongs to the Dps family
Arch_1469	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Arch_1470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Arch_1471	COG1333	cytochrome c biogenesis protein
Arch_1472	COG0785	Cytochrome C biogenesis protein
Arch_1474	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Arch_1476	COG0698	ribose 5-phosphate isomerase
Arch_1477	COG0235	Class ii aldolase
Arch_1480	COG3663	DNA glycosylase
Arch_1485	COG0733	neurotransmitter:sodium symporter activity
Arch_1486	COG1131	(ABC) transporter
Arch_1487	COG3119	arylsulfatase activity
Arch_1489	COG2814	Major facilitator Superfamily
Arch_1490	COG0641	radical SAM
Arch_1494	COG0012	GTP binding
Arch_1495	COG1322	Protein conserved in bacteria
Arch_1499	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Arch_1501	COG1722	exodeoxyribonuclease VII activity
Arch_1502	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Arch_1502	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Arch_1503	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Arch_1505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Arch_1506	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Arch_1509	COG1131	(ABC) transporter
Arch_1516	COG0148	phosphopyruvate hydratase activity
Arch_1518	COG0193	aminoacyl-tRNA hydrolase activity
Arch_1519	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Arch_1521	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Arch_1522	COG1309	transcriptional regulator
Arch_1523	COG4152	abc transporter atp-binding protein
Arch_1524	COG1668	transmembrane transport
Arch_1549	COG0740	serine-type endopeptidase activity
Arch_1550	COG4695	Portal protein
Arch_1551	COG0640	Transcriptional regulator
Arch_1553	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Arch_1569	COG2963	transposase activity
Arch_1575	COG1122	ATPase activity
Arch_1586	COG0488	(ABC) transporter
Arch_1587	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Arch_1589	COG1263	PTS System
Arch_1589	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Arch_1591	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Arch_1593	COG0084	hydrolase, TatD family'
Arch_1594	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Arch_1595	COG1335	isochorismatase
Arch_1596	COG5646	InterPro IPR014922
Arch_1597	COG2409	Drug exporters of the RND superfamily
Arch_1601	COG1131	(ABC) transporter
Arch_1603	COG4585	Histidine kinase
Arch_1604	COG2197	response regulator
Arch_1605	COG2813	Specifically methylates the guanine in position
Arch_1610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Arch_1612	COG1970	mechanosensitive ion channel activity
Arch_1617	COG0791	NLP P60 protein
Arch_1617	COG1388	LysM domain
Arch_1617	COG3103	Sh3 type 3 domain protein
Arch_1619	COG2252	PERMEase
Arch_1620	COG1482	cell wall glycoprotein biosynthetic process
Arch_1622	COG1278	Cold shock
Arch_1624	COG1842	Phage shock protein A
Arch_1626	COG0745	RESPONSE REGULATOR receiver
Arch_1627	COG2205	protein histidine kinase activity
Arch_1631	COG0459	protein refolding
Arch_1634	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Arch_1636	COG0156	8-amino-7-oxononanoate synthase activity
Arch_1637	COG1063	alcohol dehydrogenase
Arch_1638	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Arch_1640	COG1115	amino acid carrier protein
Arch_1643	COG3842	ATPase activity
Arch_1645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Arch_1649	COG2963	transposase activity
Arch_1655	COG2233	PERMEase
Arch_1658	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Arch_1659	COG0215	cysteine-tRNA ligase activity
Arch_1661	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Arch_1662	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Arch_1663	COG1329	Transcriptional regulator
Arch_1664	COG0745	RESPONSE REGULATOR receiver
Arch_1667	COG0588	phosphoglycerate mutase activity
Arch_1670	COG0446	pyridine nucleotide-disulphide oxidoreductase
Arch_1675	COG0640	Transcriptional regulator
Arch_1679	COG1192	Involved in chromosome partitioning
Arch_1693	COG0741	lytic transglycosylase activity
Arch_1693	COG1196	nuclear chromosome segregation
Arch_1693	COG0739	heme binding
Arch_1703	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Arch_1704	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Arch_1704	COG1754	DNA topoisomerase type I activity
Arch_1705	COG2890	protein-(glutamine-N5) methyltransferase activity
Arch_1708	COG1111	helicase
Arch_1708	COG1205	dead DEAH box helicase
Arch_1719	COG0596	Alpha beta hydrolase
Arch_1722	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Arch_1727	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Arch_1729	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Arch_1731	COG0738	Major facilitator superfamily
Arch_1739	COG4868	Belongs to the UPF0371 family
Arch_1744	COG0590	tRNA wobble adenosine to inosine editing
Arch_1745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Arch_1748	COG0463	Glycosyl transferase, family 2
Arch_1752	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Arch_1753	COG0561	phosphatase activity
Arch_1768	COG0477	Major facilitator Superfamily
Arch_1771	COG0471	metal ion transport
Arch_1772	COG0366	Alpha amylase catalytic
Arch_1772	COG1470	cell adhesion involved in biofilm formation
Arch_1774	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Arch_1775	COG1492	cobalamin metabolic process
Arch_1776	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Arch_1781	COG2963	transposase activity
Arch_1783	COG1643	Atp-dependent helicase
Arch_1786	COG0343	queuine tRNA-ribosyltransferase activity
Arch_1790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Arch_1790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Arch_1794	COG0305	Participates in initiation and elongation during chromosome replication
Arch_1799	COG0359	binds to the 23S rRNA
Arch_1800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Arch_1802	COG0360	Binds together with S18 to 16S ribosomal RNA
Arch_1803	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Arch_1804	COG0628	permease
Arch_1806	COG0617	tRNA 3'-terminal CCA addition
Arch_1812	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Arch_1814	COG1192	Involved in chromosome partitioning
Arch_1815	COG0357	Ribosomal RNA small subunit methyltransferase G
Arch_1816	COG3547	Transposase (IS116 IS110 IS902 family)
Arch_1817	COG1847	R3H domain protein
Arch_1818	COG0706	membrane insertase activity
Arch_1819	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Arch_1820	COG0594	ribonuclease P activity
Arch_1821	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Arch_R0043	COG0488	(ABC) transporter