locus-tag	class	description
AF_0004	COG4604	ABC transporter, ATP-binding protein
AF_0006	COG5012	cobalamin binding
AF_0009	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
AF_0011	COG5012	cobalamin binding
AF_0017	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_0018	COG0183	Belongs to the thiolase family
AF_0021	COG3290	protein histidine kinase activity
AF_0023	COG2414	aldehyde ferredoxin oxidoreductase
AF_0027	COG4274	PFAM GYD family protein
AF_0033	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AF_0034	COG0183	Belongs to the thiolase family
AF_0036	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AF_0037	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AF_0038	COG0438	transferase activity, transferring glycosyl groups
AF_0039	COG1216	Glycosyl transferase, family 2
AF_0043	COG0438	transferase activity, transferring glycosyl groups
AF_0044	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AF_0050	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AF_0051	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AF_0061	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AF_0062	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AF_0074	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AF_0074	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AF_0076	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AF_0080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AF_0086	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AF_0088	COG1116	anion transmembrane transporter activity
AF_0088	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AF_0089	COG0318	PFAM AMP-dependent synthetase and ligase
AF_0092	COG3842	ATPase activity
AF_0093	COG4149	molybdate abc transporter
AF_0094	COG0725	ABC transporter, periplasmic molybdate-binding protein
AF_0106	COG0540	Belongs to the ATCase OTCase family
AF_0107	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AF_0108	COG1830	Aldolase
AF_0110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AF_0112	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AF_0115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AF_0140	COG2226	methyltransferase
AF_0154	COG0672	)-iron permease
AF_0157	COG0437	4 iron, 4 sulfur cluster binding
AF_0164	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AF_0166	COG1141	Ferredoxin
AF_0167	COG0426	domain, Protein
AF_0171	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AF_0176	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AF_0185	COG0822	iron-sulfur transferase activity
AF_0186	COG1104	cysteine desulfurase activity
AF_0188	COG0425	Belongs to the sulfur carrier protein TusA family
AF_0191	COG2217	Heavy metal translocating P-type atpase
AF_0192	COG2217	Heavy metal translocating P-type atpase
AF_0196	COG0318	PFAM AMP-dependent synthetase and ligase
AF_0197	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_0198	COG2030	dehydratase
AF_0198	COG1012	belongs to the aldehyde dehydrogenase family
AF_0200	COG1022	Amp-dependent synthetase and ligase
AF_0205	COG2264	protein methyltransferase activity
AF_0208	COG0642	Histidine kinase
AF_0209	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AF_0211	COG2239	Acts as a magnesium transporter
AF_0212	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AF_0216	COG2264	protein methyltransferase activity
AF_0217	COG0569	domain protein
AF_0217	COG0475	glutathione-regulated potassium exporter activity
AF_0219	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AF_0220	COG0439	Biotin carboxylase
AF_0221	COG0410	ABC transporter
AF_0222	COG0411	ABC transporter
AF_0224	COG0559	Belongs to the binding-protein-dependent transport system permease family
AF_0227	COG1605	Chorismate mutase
AF_0227	COG0077	Prephenate dehydratase
AF_0228	COG0710	3-dehydroquinate dehydratase activity
AF_0229	COG1465	3-dehydroquinate synthase
AF_0230	COG1830	Aldolase
AF_0231	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AF_0234	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AF_0235	COG0501	Belongs to the peptidase M48B family
AF_0239	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AF_0240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AF_0242	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AF_0246	COG1918	ferrous iron import across plasma membrane
AF_0246	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AF_0252	COG0504	CTP synthase activity
AF_0253	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AF_0253	COG0519	Catalyzes the synthesis of GMP from XMP
AF_0254	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_0262	COG0318	PFAM AMP-dependent synthetase and ligase
AF_0263	COG1213	nucleotidyl transferase
AF_0263	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AF_0270	COG0450	alkyl hydroperoxide reductase
AF_0274	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AF_0276	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AF_0280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AF_0283	COG0183	Belongs to the thiolase family
AF_0285	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_0287	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AF_0288	COG0529	Catalyzes the synthesis of activated sulfate
AF_0302	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AF_0321	COG1442	glycosyl transferase family 8
AF_0321	COG1216	Glycosyl transferase, family 2
AF_0324	COG1088	dTDP-glucose 4,6-dehydratase activity
AF_0327	COG0438	transferase activity, transferring glycosyl groups
AF_0328	COG1216	Glycosyl transferase, family 2
AF_0339	COG1454	alcohol dehydrogenase
AF_0344	COG2033	superoxide reductase activity
AF_0346	COG2217	Heavy metal translocating P-type atpase
AF_0355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AF_0356	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AF_0358	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AF_0364	COG1067	ATP-dependent peptidase activity
AF_0364	COG0470	DNA polymerase III
AF_0366	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_0367	COG2271	Major facilitator Superfamily
AF_0370	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AF_0371	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
AF_0372	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AF_0374	COG0647	UMP catabolic process
AF_0386	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AF_0388	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AF_0390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AF_0393	COG1131	(ABC) transporter
AF_0394	COG0277	FAD linked oxidase domain protein
AF_0395	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_0400	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_0409	COG0436	Aminotransferase
AF_0410	COG4191	Histidine kinase
AF_0411	COG0215	cysteine-tRNA ligase activity
AF_0419	COG0434	BtpA family
AF_0422	COG1648	precorrin-2 dehydrogenase activity
AF_0422	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AF_0423	COG2221	Nitrite and sulphite reductase 4Fe-4S
AF_0424	COG2221	Nitrite and sulphite reductase 4Fe-4S
AF_0428	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AF_0431	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AF_0433	COG1720	tRNA m6t6A37 methyltransferase activity
AF_0434	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_0435	COG1024	Enoyl-CoA hydratase
AF_0436	COG1960	acyl-CoA dehydrogenase activity
AF_0438	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AF_0440	COG0720	synthase
AF_0441	COG0602	queuosine metabolic process
AF_0442	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AF_0448	COG5002	protein histidine kinase activity
AF_0449	COG2201	protein-glutamate methylesterase activity
AF_0450	COG3290	protein histidine kinase activity
AF_0452	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AF_0455	COG1902	pentaerythritol trinitrate reductase activity
AF_0455	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_0458	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AF_0459	COG2409	Drug exporters of the RND superfamily
AF_0465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AF_0468	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF_0469	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AF_0469	COG0674	pyruvate-flavodoxin oxidoreductase activity
AF_0473	COG2217	Heavy metal translocating P-type atpase
AF_0474	COG1522	sequence-specific DNA binding
AF_0475	COG0798	PFAM Bile acid sodium symporter
AF_0477	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_0478	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AF_0481	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AF_0482	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AF_0484	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AF_0484	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AF_0492	COG1185	polyribonucleotide nucleotidyltransferase activity
AF_0493	COG1185	polyribonucleotide nucleotidyltransferase activity
AF_0494	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AF_0497	COG0417	DNA replication proofreading
AF_0506	COG0247	lactate metabolic process
AF_0506	COG2181	nitrate reductase activity
AF_0508	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AF_0509	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AF_0512	COG2226	methyltransferase
AF_0522	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AF_0527	COG1185	polyribonucleotide nucleotidyltransferase activity
AF_0528	COG0543	2 iron, 2 sulfur cluster binding
AF_0530	COG0187	DNA topoisomerase II activity
AF_0531	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AF_0535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AF_0538	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AF_0544	COG0247	lactate metabolic process
AF_0547	COG0247	lactate metabolic process
AF_0550	COG0402	S-adenosylhomocysteine deaminase activity
AF_0551	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AF_0552	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AF_0553	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AF_0556	COG0425	Belongs to the sulfur carrier protein TusA family
AF_0557	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_0559	COG0482	sulfurtransferase activity
AF_0564	COG1104	cysteine desulfurase activity
AF_0565	COG0822	iron-sulfur transferase activity
AF_0568	COG0318	PFAM AMP-dependent synthetase and ligase
AF_0570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AF_0575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_0580	COG0708	Exodeoxyribonuclease III
AF_0581	COG0463	Glycosyl transferase, family 2
AF_0588	COG0343	queuine tRNA-ribosyltransferase activity
AF_0589	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AF_0590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AF_0592	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AF_0596	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AF_0617	COG0297	glycogen (starch) synthase activity
AF_0621	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AF_0623	COG1793	dna ligase
AF_0628	COG0473	3-isopropylmalate dehydrogenase activity
AF_0629	COG0066	3-isopropylmalate dehydratase activity
AF_0632	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AF_0633	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AF_0639	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AF_0640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AF_0640	COG1116	anion transmembrane transporter activity
AF_0646	COG0010	Belongs to the arginase family
AF_0647	COG0538	isocitrate dehydrogenase activity
AF_0654	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_0655	COG0312	modulator of DNA gyrase
AF_0660	COG1694	Mazg nucleotide pyrophosphohydrolase
AF_0662	COG3976	FMN-binding domain protein
AF_0662	COG1053	succinate dehydrogenase
AF_0662	COG0431	NADPH-dependent FMN reductase
AF_0663	COG1233	COG1233 Phytoene dehydrogenase and related
AF_0665	COG2815	serine threonine protein kinase
AF_0665	COG0515	serine threonine protein kinase
AF_0670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AF_0671	COG1960	acyl-CoA dehydrogenase activity
AF_0672	COG0318	PFAM AMP-dependent synthetase and ligase
AF_0676	COG0563	adenylate kinase activity
AF_0677	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_0679	COG3335	DDE superfamily endonuclease
AF_0681	COG1053	succinate dehydrogenase
AF_0685	COG1024	Enoyl-CoA hydratase
AF_0687	COG0318	PFAM AMP-dependent synthetase and ligase
AF_0691	COG2871	sodium ion transport
AF_0696	COG2894	cell division
AF_0702	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
AF_0707	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AF_0710	COG0574	Belongs to the PEP-utilizing enzyme family
AF_0710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AF_0713	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AF_0728	COG0310	cobalt ion transport
AF_0731	COG1122	ATPase activity
AF_0733	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AF_0737	COG2104	thiamine diphosphate biosynthetic process
AF_0741	COG0432	Pfam Uncharacterised protein family UPF0047
AF_0743	COG0864	Transcriptional regulator
AF_0745	COG0167	dihydroorotate dehydrogenase activity
AF_0747	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AF_0750	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF_0755	COG0247	lactate metabolic process
AF_0755	COG2181	nitrate reductase activity
AF_0756	COG1227	inorganic diphosphatase activity
AF_0767	COG0105	UTP biosynthetic process
AF_0770	COG5002	protein histidine kinase activity
AF_0776	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AF_0781	COG0009	L-threonylcarbamoyladenylate synthase
AF_0784	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AF_0786	COG0598	Magnesium transport protein CorA
AF_0788	COG0697	spore germination
AF_0797	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AF_0798	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AF_0800	COG0019	diaminopimelate decarboxylase activity
AF_0806	COG1620	l-lactate permease
AF_0808	COG0277	FAD linked oxidase domain protein
AF_0811	COG1139	Iron-sulfur cluster binding protein
AF_0813	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AF_0815	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
AF_0818	COG1254	Belongs to the acylphosphatase family
AF_0819	COG0107	imidazoleglycerol-phosphate synthase activity
AF_0822	COG0410	ABC transporter
AF_0823	COG0411	ABC transporter
AF_0825	COG0559	Belongs to the binding-protein-dependent transport system permease family
AF_0830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AF_0830	COG1773	rubredoxin
AF_0831	COG1592	Rubrerythrin
AF_0833	COG2033	superoxide reductase activity
AF_0838	COG0569	domain protein
AF_0840	COG0318	PFAM AMP-dependent synthetase and ligase
AF_0841	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AF_0845	COG1960	acyl-CoA dehydrogenase activity
AF_0847	COG0517	IMP dehydrogenase activity
AF_0847	COG1125	glycine betaine transport
AF_0848	COG0517	IMP dehydrogenase activity
AF_0852	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AF_0855	COG0039	L-malate dehydrogenase activity
AF_0865	COG0596	Alpha beta hydrolase
AF_0868	COG0277	FAD linked oxidase domain protein
AF_0869	COG0393	Putative heavy-metal-binding
AF_0871	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AF_0873	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AF_0876	COG4085	toxin activity
AF_0876	COG1525	nuclease
AF_0876	COG0737	Belongs to the 5'-nucleotidase family
AF_0880	COG1773	rubredoxin
AF_0882	COG0252	asparaginase activity
AF_0886	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AF_0893	COG3290	protein histidine kinase activity
AF_0904	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AF_0907	COG2271	Major facilitator Superfamily
AF_0909	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AF_0910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AF_0914	COG0023	Translation Initiation Factor
AF_0916	COG0423	glycine-tRNA ligase activity
AF_0920	COG0017	Asparaginyl-tRNA synthetase
AF_0928	COG0546	phosphoglycolate phosphatase activity
AF_0929	COG0284	orotidine-5'-phosphate decarboxylase activity
AF_0930	COG0303	'Molybdopterin
AF_0931	COG0303	'Molybdopterin
AF_0933	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AF_0935	COG0460	homoserine dehydrogenase
AF_0937	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AF_0938	COG0051	transcription antitermination factor activity, RNA binding
AF_0939	COG1234	tRNA 3'-trailer cleavage
AF_0942	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AF_0943	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AF_0949	COG0174	glutamine synthetase
AF_0950	COG0437	4 iron, 4 sulfur cluster binding
AF_0951	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AF_0952	COG0067	glutamate synthase
AF_0953	COG0069	glutamate synthase activity
AF_0953	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AF_0957	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AF_0959	COG1137	ATPase activity
AF_0963	COG1024	Enoyl-CoA hydratase
AF_0969	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AF_0972	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AF_0973	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AF_0974	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AF_0975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_0976	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_0977	COG0004	ammonium transporteR
AF_0980	COG1174	glycine betaine transport
AF_0981	COG0517	IMP dehydrogenase activity
AF_0981	COG1125	glycine betaine transport
AF_0984	COG4555	ABC transporter
AF_0985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AF_0985	COG0131	Imidazoleglycerol-phosphate dehydratase
AF_0986	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AF_0994	COG1418	mRNA catabolic process
AF_0997	COG0402	S-adenosylhomocysteine deaminase activity
AF_1005	COG0842	Transport permease protein
AF_1006	COG1131	(ABC) transporter
AF_1009	COG1378	Sugar-specific transcriptional regulator TrmB
AF_1014	COG0129	dihydroxy-acid dehydratase activity
AF_1017	COG0577	efflux transmembrane transporter activity
AF_1018	COG1136	(ABC) transporter
AF_1021	COG1131	(ABC) transporter
AF_1023	COG0644	oxidoreductase
AF_1024	COG1110	DNA topoisomerase II activity
AF_1025	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_1026	COG1960	acyl-CoA dehydrogenase activity
AF_1028	COG0183	Belongs to the thiolase family
AF_1029	COG0318	PFAM AMP-dependent synthetase and ligase
AF_1030	COG0433	COG0433 Predicted ATPase
AF_1034	COG3290	protein histidine kinase activity
AF_1034	COG0840	transmembrane signaling receptor activity
AF_1038	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AF_1039	COG1776	CheC inhibitor of MCP methylation
AF_1040	COG0643	Histidine kinase
AF_1040	COG2198	Histidine kinase
AF_1041	COG2201	protein-glutamate methylesterase activity
AF_1042	COG2201	protein-glutamate methylesterase activity
AF_1044	COG0835	chemotaxis
AF_1045	COG3290	protein histidine kinase activity
AF_1045	COG0840	transmembrane signaling receptor activity
AF_1063	COG2201	protein-glutamate methylesterase activity
AF_1064	COG1121	(ABC) transporter
AF_1069	COG4145	pantothenate transmembrane transporter activity
AF_1072	COG1598	PFAM Uncharacterised protein family UPF0150
AF_1112	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AF_1117	COG1185	polyribonucleotide nucleotidyltransferase activity
AF_1122	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_1128	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AF_1129	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AF_1132	COG0148	phosphopyruvate hydratase activity
AF_1133	COG0052	Belongs to the universal ribosomal protein uS2 family
AF_1139	COG1131	(ABC) transporter
AF_1142	COG1213	nucleotidyl transferase
AF_1145	COG0427	acetyl-CoA hydrolase
AF_1146	COG0126	phosphoglycerate kinase activity
AF_1147	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AF_1148	COG1522	sequence-specific DNA binding
AF_1149	COG1201	RNA secondary structure unwinding
AF_1157	COG0151	Belongs to the GarS family
AF_1159	COG1269	ATP hydrolysis coupled proton transport
AF_1164	COG1527	subunit (C
AF_1166	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AF_1167	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AF_1168	COG1394	ATPase activity, coupled to movement of substances
AF_1169	COG1268	BioY protein
AF_1170	COG1122	ATPase activity
AF_1175	COG1960	acyl-CoA dehydrogenase activity
AF_1177	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_1184	COG4191	Histidine kinase
AF_1186	COG0516	GMP reductase activity
AF_1186	COG0517	IMP dehydrogenase activity
AF_1190	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_1191	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AF_1192	COG0045	succinate-CoA ligase (ADP-forming) activity
AF_1192	COG1042	CoA-binding domain protein
AF_1192	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AF_1195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AF_1196	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AF_1197	COG0183	Belongs to the thiolase family
AF_1199	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AF_1202	COG0437	4 iron, 4 sulfur cluster binding
AF_1206	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_1207	COG1028	Short-chain dehydrogenase reductase Sdr
AF_1210	COG3246	L-lysine catabolic process to acetate
AF_1211	COG1042	CoA-binding domain protein
AF_1211	COG0045	succinate-CoA ligase (ADP-forming) activity
AF_1211	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AF_1212	COG0857	belongs to the CobB CobQ family
AF_1215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AF_1216	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AF_1219	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AF_1224	COG1418	mRNA catabolic process
AF_1229	COG2409	Drug exporters of the RND superfamily
AF_1232	COG1378	Sugar-specific transcriptional regulator TrmB
AF_1240	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AF_1241	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AF_1242	COG0181	hydroxymethylbilane synthase activity
AF_1243	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AF_1245	COG0475	glutathione-regulated potassium exporter activity
AF_1247	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AF_1248	COG1811	Na channel or pump
AF_1255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AF_1256	COG2201	protein-glutamate methylesterase activity
AF_1257	COG0116	Belongs to the methyltransferase superfamily
AF_1259	COG1125	glycine betaine transport
AF_1259	COG0517	IMP dehydrogenase activity
AF_1260	COG0047	phosphoribosylformylglycinamidine synthase activity
AF_1261	COG0318	PFAM AMP-dependent synthetase and ligase
AF_1262	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_1262	COG1902	pentaerythritol trinitrate reductase activity
AF_1265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AF_1271	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AF_1272	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AF_1273	COG0505	Belongs to the CarA family
AF_1274	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AF_1275	COG1691	(AIR) carboxylase
AF_1277	COG0505	Belongs to the CarA family
AF_1280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AF_1281	COG0693	protein deglycase activity
AF_1285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_1287	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_1291	COG0183	Belongs to the thiolase family
AF_1293	COG1960	acyl-CoA dehydrogenase activity
AF_1297	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_1300	COG1131	(ABC) transporter
AF_1304	COG0149	triose-phosphate isomerase activity
AF_1305	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
AF_1308	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AF_1309	COG0170	dolichyl monophosphate biosynthetic process
AF_1311	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AF_1315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AF_1316	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AF_1320	COG0519	Catalyzes the synthesis of GMP from XMP
AF_1320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AF_1321	COG0037	tRNA processing
AF_1326	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AF_1328	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AF_1336	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AF_1338	COG1492	cobalamin metabolic process
AF_1339	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AF_1340	COG0372	Belongs to the citrate synthase family
AF_1343	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_1344	COG0805	protein transport
AF_1349	COG1773	rubredoxin
AF_1350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_1352	COG3335	DDE superfamily endonuclease
AF_1354	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AF_1354	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AF_1356	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AF_1357	COG0573	inorganic phosphate transmembrane transporter activity
AF_1358	COG0581	inorganic phosphate transmembrane transporter activity
AF_1359	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AF_1360	COG0704	Plays a role in the regulation of phosphate uptake
AF_1364	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AF_1366	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AF_1367	COG0375	protein maturation
AF_1370	COG0409	Hydrogenase expression formation protein
AF_1372	COG3259	Nickel-dependent hydrogenase
AF_1373	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AF_1378	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AF_1381	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AF_1384	COG2201	protein-glutamate methylesterase activity
AF_1398	COG1657	PFAM Prenyltransferase squalene oxidase
AF_1401	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AF_1402	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AF_1409	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AF_1417	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AF_1420	COG0330	HflC and HflK could
AF_1421	COG1615	UPF0182 protein
AF_1422	COG1794	racemase activity, acting on amino acids and derivatives
AF_1423	COG1078	dGTPase activity
AF_1425	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AF_1426	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AF_1433	COG1628	Protein of unknown function DUF99
AF_1435	COG0430	RNA-3'-phosphate cyclase activity
AF_1440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AF_1442	COG1980	fructose-bisphosphate aldolase activity
AF_1443	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AF_1448	COG1522	sequence-specific DNA binding
AF_1452	COG5002	protein histidine kinase activity
AF_1453	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AF_1453	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AF_1463	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AF_1469	COG1136	(ABC) transporter
AF_1470	COG1136	(ABC) transporter
AF_1470	COG0577	efflux transmembrane transporter activity
AF_1473	COG0784	Response regulator, receiver
AF_1475	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AF_1476	COG0346	lactoylglutathione lyase activity
AF_1484	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AF_1485	COG0343	queuine tRNA-ribosyltransferase activity
AF_1486	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
AF_1488	COG1051	belongs to the nudix hydrolase family
AF_1488	COG1056	cytidyltransferase-related domain
AF_1490	COG0081	regulation of translation
AF_1491	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AF_1510	COG0318	PFAM AMP-dependent synthetase and ligase
AF_1512	COG0805	protein transport
AF_1516	COG1489	DNA binding
AF_1520	COG0426	domain, Protein
AF_1522	COG1444	tRNA N-acetyltransferase activity
AF_1537	COG2267	carboxylic ester hydrolase activity
AF_1538	COG2031	fatty acid transporter
AF_1539	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AF_1542	COG1695	Transcriptional regulator
AF_1546	COG0668	transmembrane transport
AF_1551	COG0142	geranyltranstransferase activity
AF_1553	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AF_1554	COG0492	ferredoxin-NADP+ reductase activity
AF_1556	COG0482	sulfurtransferase activity
AF_1558	COG1196	nuclear chromosome segregation
AF_1580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AF_1587	COG1850	ribulose-bisphosphate carboxylase activity
AF_1595	COG0037	tRNA processing
AF_1600	COG0133	tryptophan synthase activity
AF_1601	COG0135	phosphoribosylanthranilate isomerase activity
AF_1602	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AF_1602	COG0512	Glutamine amidotransferase of anthranilate synthase
AF_1603	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AF_1604	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AF_1606	COG1177	transmembrane transport
AF_1607	COG1176	ABC-type spermidine putrescine transport system, permease component I
AF_1608	COG3842	ATPase activity
AF_1610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AF_1612	COG1113	amino acid transport
AF_1615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AF_1618	COG2855	membrane
AF_1619	COG2855	membrane
AF_1621	COG2855	membrane
AF_1622	COG1522	sequence-specific DNA binding
AF_1623	COG0436	Aminotransferase
AF_1624	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AF_1630	COG1945	arginine decarboxylase activity
AF_1638	COG1850	ribulose-bisphosphate carboxylase activity
AF_1639	COG5002	protein histidine kinase activity
AF_1640	COG1592	Rubrerythrin
AF_1641	COG1024	Enoyl-CoA hydratase
AF_1642	COG0124	histidyl-tRNA synthetase
AF_1643	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AF_1645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AF_1652	COG1404	Belongs to the peptidase S8 family
AF_1653	COG1404	Belongs to the peptidase S8 family
AF_1671	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AF_1674	COG0371	Dehydrogenase
AF_1676	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AF_1677	COG0585	pseudouridine synthase activity
AF_1692	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AF_1693	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AF_1695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AF_1698	COG1881	PFAM PEBP family protein
AF_1701	COG0674	pyruvate-flavodoxin oxidoreductase activity
AF_1702	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF_1704	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AF_1706	COG2267	carboxylic ester hydrolase activity
AF_1708	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AF_1710	COG0732	type I restriction modification DNA specificity domain
AF_1717	COG2427	Protein of unknown function (DUF1641)
AF_1719	COG0440	acetolactate synthase activity
AF_1720	COG0028	Belongs to the TPP enzyme family
AF_1726	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AF_1727	COG0281	malic enzyme
AF_1728	COG0297	glycogen (starch) synthase activity
AF_1730	COG0101	tRNA pseudouridine synthase activity
AF_1737	COG1331	Highly conserved protein containing a thioredoxin domain
AF_1741	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AF_1744	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AF_1746	COG0004	ammonium transporteR
AF_1747	COG0347	Belongs to the P(II) protein family
AF_1748	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_1749	COG0004	ammonium transporteR
AF_1751	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AF_1752	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AF_1755	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AF_1761	COG0066	3-isopropylmalate dehydratase activity
AF_1764	COG2131	deaminase
AF_1765	COG0084	hydrolase, TatD family'
AF_1767	COG0747	negative chemotaxis
AF_1768	COG0601	transmembrane transport
AF_1770	COG0444	Belongs to the ABC transporter superfamily
AF_1771	COG4608	Belongs to the ABC transporter superfamily
AF_1772	COG0318	PFAM AMP-dependent synthetase and ligase
AF_1773	COG0247	lactate metabolic process
AF_1773	COG2181	nitrate reductase activity
AF_1774	COG0531	amino acid
AF_1777	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AF_1778	COG2088	sporulation resulting in formation of a cellular spore
AF_1779	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AF_1780	COG0028	Belongs to the TPP enzyme family
AF_1783	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AF_1787	COG1426	Protein conserved in bacteria
AF_1788	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AF_1795	COG1363	Peptidase, m42
AF_1798	COG0306	phosphate transporter
AF_1801	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AF_1811	COG0138	bifunctional purine biosynthesis protein purh
AF_1813	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_1817	COG1309	transcriptional regulator
AF_1819	COG1136	(ABC) transporter
AF_1825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AF_1826	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AF_1827	COG1007	ATP synthesis coupled electron transport
AF_1829	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AF_1839	COG0157	Belongs to the NadC ModD family
AF_1840	COG0024	Methionine aminopeptidase
AF_1841	COG1122	ATPase activity
AF_1843	COG0310	cobalt ion transport
AF_1849	COG1151	hydroxylamine reductase activity
AF_1854	COG0427	acetyl-CoA hydrolase
AF_1855	COG0318	PFAM AMP-dependent synthetase and ligase
AF_1858	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_1876	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AF_1884	COG1131	(ABC) transporter
AF_1886	COG0085	RNA polymerase activity
AF_1891	COG0195	Participates in both transcription termination and antitermination
AF_1894	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AF_1896	COG0655	NAD(P)H dehydrogenase (quinone) activity
AF_1898	COG2201	protein-glutamate methylesterase activity
AF_1899	COG0358	DNA primase activity
AF_1903	COG0200	Binds to the 23S rRNA
AF_1905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AF_1906	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AF_1909	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AF_1910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AF_1912	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AF_1914	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AF_1915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AF_1916	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AF_1918	COG0255	Belongs to the universal ribosomal protein uL29 family
AF_1919	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AF_1920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AF_1921	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AF_1922	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AF_1923	COG0089	rRNA binding
AF_1925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AF_1930	COG1229	Formylmethanofuran dehydrogenase subunit A
AF_1932	COG0318	PFAM AMP-dependent synthetase and ligase
AF_1935	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AF_1940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AF_1941	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AF_1950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AF_1950	COG0140	phosphoribosyl-ATP diphosphatase activity
AF_1951	COG4956	integral membrane protein (PIN domain superfamily)
AF_1954	COG0154	amidase activity
AF_1955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AF_1959	COG1924	4 iron, 4 sulfur cluster binding
AF_1960	COG0194	GDP metabolic process
AF_1963	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AF_1968	COG1940	carbohydrate kinase activity
AF_1969	COG2078	PFAM AMMECR1 domain protein
AF_1971	COG0071	Belongs to the small heat shock protein (HSP20) family
AF_1973	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AF_1974	COG0113	porphobilinogen synthase activity
AF_1975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AF_1976	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_1980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AF_1981	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AF_1982	COG1121	(ABC) transporter
AF_1983	COG0803	Belongs to the bacterial solute-binding protein 9 family
AF_1985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AF_1989	COG1047	Peptidyl-prolyl cis-trans
AF_1995	COG0733	neurotransmitter:sodium symporter activity
AF_1998	COG0247	lactate metabolic process
AF_1998	COG2181	nitrate reductase activity
AF_2000	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AF_2002	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AF_2005	COG0746	molybdenum cofactor guanylyltransferase activity
AF_2006	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AF_2007	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AF_2007	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AF_2009	COG0535	radical SAM domain protein
AF_2013	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AF_2015	COG0028	Belongs to the TPP enzyme family
AF_2017	COG1024	Enoyl-CoA hydratase
AF_2017	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_2019	COG1454	alcohol dehydrogenase
AF_2032	COG5002	protein histidine kinase activity
AF_2033	COG0318	PFAM AMP-dependent synthetase and ligase
AF_2034	COG0006	proline dipeptidase activity
AF_2035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AF_2036	COG0109	protoheme IX farnesyltransferase activity
AF_2037	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AF_2042	COG0528	UMP kinase activity
AF_2044	COG1183	phosphatidylcholine synthase activity
AF_2045	COG0688	phosphatidylethanolamine metabolic process
AF_2047	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AF_2050	COG0432	Pfam Uncharacterised protein family UPF0047
AF_2051	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AF_2052	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF_2053	COG0674	pyruvate-flavodoxin oxidoreductase activity
AF_2054	COG1144	Oxidoreductase
AF_2056	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AF_2057	COG1960	acyl-CoA dehydrogenase activity
AF_2062	COG0552	protein localization to endoplasmic reticulum
AF_2071	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AF_2073	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AF_2074	COG0352	thiamine-phosphate diphosphorylase activity
AF_2075	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AF_2084	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AF_2085	COG0511	ligase activity, forming carbon-carbon bonds
AF_2085	COG5016	pyruvate
AF_2089	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AF_2098	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_2100	COG0028	Belongs to the TPP enzyme family
AF_2109	COG3290	protein histidine kinase activity
AF_2111	COG2095	MarC family integral membrane protein
AF_2116	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AF_2127	COG0583	DNA-binding transcription factor activity
AF_2128	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AF_2129	COG0436	Aminotransferase
AF_2136	COG0640	Transcriptional regulator
AF_2137	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AF_2138	COG0560	Phosphoserine phosphatase
AF_2138	COG3830	Belongs to the UPF0237 family
AF_2139	COG3335	DDE superfamily endonuclease
AF_2146	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AF_2148	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_2150	COG0315	cyclic pyranopterin monophosphate synthase activity
AF_2151	COG1335	isochorismatase
AF_2155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AF_2157	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AF_2178	COG0116	Belongs to the methyltransferase superfamily
AF_2178	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AF_2179	COG0314	molybdopterin synthase activity
AF_2184	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AF_2185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AF_2186	COG0045	succinate-CoA ligase (ADP-forming) activity
AF_2192	COG1138	Cytochrome C-type biogenesis protein
AF_2194	COG2264	protein methyltransferase activity
AF_2195	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AF_2196	COG1891	lyase activity
AF_2199	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AF_2200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AF_2207	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AF_2208	COG0352	thiamine-phosphate diphosphorylase activity
AF_2208	COG0351	phosphomethylpyrimidine kinase
AF_2208	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AF_2216	COG0511	ligase activity, forming carbon-carbon bonds
AF_2216	COG5016	pyruvate
AF_2218	COG0346	lactoylglutathione lyase activity
AF_2224	COG0525	valine-tRNA ligase activity
AF_2226	COG0301	tRNA thio-modification
AF_2226	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF_2229	COG1797	cobyrinic acid a,c-diamide synthase activity
AF_2232	COG0735	belongs to the Fur family
AF_2233	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AF_2237	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AF_2242	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AF_2243	COG0183	Belongs to the thiolase family
AF_2244	COG1960	acyl-CoA dehydrogenase activity
AF_2249	COG2201	protein-glutamate methylesterase activity
AF_2251	COG1058	Belongs to the CinA family
AF_2251	COG1546	Belongs to the CinA family
AF_2252	COG0137	argininosuccinate synthase activity
AF_2253	COG1763	Mo-molybdopterin cofactor biosynthetic process
AF_2254	COG0513	Belongs to the DEAD box helicase family
AF_2255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AF_2256	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AF_2256	COG0778	Nitroreductase
AF_2257	COG1181	Belongs to the D-alanine--D-alanine ligase family
AF_2258	COG2814	Major facilitator Superfamily
AF_2264	COG2050	protein possibly involved in aromatic compounds catabolism
AF_2265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AF_2266	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_2267	COG0778	Nitroreductase
AF_2269	COG0489	protein tyrosine kinase activity
AF_2273	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_2277	COG1573	uracil-dna glycosylase
AF_2281	COG2414	aldehyde ferredoxin oxidoreductase
AF_2283	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AF_2284	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AF_2285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AF_2286	COG0142	geranyltranstransferase activity
AF_2288	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AF_2289	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AF_2290	COG0123	including yeast histone deacetylase and acetoin utilization protein
AF_2299	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AF_2299	COG1213	nucleotidyl transferase
AF_2301	COG1945	arginine decarboxylase activity
AF_2303	COG0189	ligase activity
AF_2310	COG1355	regulation of microtubule-based process
AF_2313	COG2030	dehydratase
AF_2313	COG1012	belongs to the aldehyde dehydrogenase family
AF_2314	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AF_2315	COG1051	belongs to the nudix hydrolase family
AF_2315	COG1056	cytidyltransferase-related domain
AF_2316	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AF_2322	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AF_2327	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AF_2328	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AF_2329	COG0154	amidase activity
AF_2334	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AF_2350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AF_2363	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AF_2365	COG0719	Fe-S assembly protein
AF_2366	COG0436	Aminotransferase
AF_2367	COG0456	acetyltransferase
AF_2368	COG0318	PFAM AMP-dependent synthetase and ligase
AF_2372	COG0483	inositol monophosphate 1-phosphatase activity
AF_2373	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AF_2380	COG0489	protein tyrosine kinase activity
AF_2382	COG0489	protein tyrosine kinase activity
AF_2388	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AF_2399	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AF_2406	COG1205	dead DEAH box helicase
AF_2406	COG1111	helicase
AF_2407	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_2409	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AF_2412	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AF_2419	COG0784	Response regulator, receiver
AF_2420	COG5002	protein histidine kinase activity
AF_2421	COG0495	leucyl-tRNA aminoacylation
AF_2425	COG0714	Associated with various cellular activities
AF_2429	COG1024	Enoyl-CoA hydratase
AF_2431	COG1945	arginine decarboxylase activity
AF_2434	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AF_2435	COG1518	maintenance of DNA repeat elements