locus-tag	class	description
Asulf_00006	COG1487	ribonuclease activity
Asulf_00011	COG0069	glutamate synthase activity
Asulf_00012	COG0067	glutamate synthase
Asulf_00013	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Asulf_00014	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Asulf_00014	COG0493	'glutamate synthase
Asulf_00016	COG1509	lysine 2,3-aminomutase activity
Asulf_00017	COG1960	acyl-CoA dehydrogenase activity
Asulf_00027	COG0438	transferase activity, transferring glycosyl groups
Asulf_00031	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Asulf_00036	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Asulf_00037	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Asulf_00039	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Asulf_00040	COG0438	transferase activity, transferring glycosyl groups
Asulf_00042	COG1215	transferase activity, transferring glycosyl groups
Asulf_00043	COG0438	transferase activity, transferring glycosyl groups
Asulf_00047	COG2194	sulfuric ester hydrolase activity
Asulf_00048	COG0673	inositol 2-dehydrogenase activity
Asulf_00050	COG1028	Short-chain dehydrogenase reductase Sdr
Asulf_00058	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Asulf_00059	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Asulf_00067	COG0552	protein localization to endoplasmic reticulum
Asulf_00077	COG2255	four-way junction helicase activity
Asulf_00078	COG1024	Enoyl-CoA hydratase
Asulf_00079	COG1233	COG1233 Phytoene dehydrogenase and related
Asulf_00080	COG5002	protein histidine kinase activity
Asulf_00082	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Asulf_00087	COG0539	negative regulation of cytoplasmic translation
Asulf_00094	COG1136	(ABC) transporter
Asulf_00099	COG1444	tRNA N-acetyltransferase activity
Asulf_00102	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Asulf_00103	COG1102	Psort location Cytoplasmic, score
Asulf_00106	COG0200	Binds to the 23S rRNA
Asulf_00108	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Asulf_00112	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Asulf_00113	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Asulf_00115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Asulf_00117	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Asulf_00118	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Asulf_00119	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Asulf_00121	COG0255	Belongs to the universal ribosomal protein uL29 family
Asulf_00122	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Asulf_00123	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Asulf_00124	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Asulf_00125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Asulf_00126	COG0089	rRNA binding
Asulf_00127	COG0088	Forms part of the polypeptide exit tunnel
Asulf_00128	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Asulf_00130	COG0505	Belongs to the CarA family
Asulf_00133	COG0785	Cytochrome C biogenesis protein
Asulf_00137	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Asulf_00138	COG1250	3-hydroxyacyl-CoA dehydrogenase
Asulf_00144	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Asulf_00150	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Asulf_00152	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Asulf_00154	COG1078	dGTPase activity
Asulf_00155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Asulf_00156	COG0084	hydrolase, TatD family'
Asulf_00162	COG0284	orotidine-5'-phosphate decarboxylase activity
Asulf_00165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Asulf_00166	COG1363	Peptidase, m42
Asulf_00169	COG0647	UMP catabolic process
Asulf_00175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Asulf_00176	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Asulf_00177	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Asulf_00180	COG2414	aldehyde ferredoxin oxidoreductase
Asulf_00181	COG5002	protein histidine kinase activity
Asulf_00186	COG1113	amino acid transport
Asulf_00188	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Asulf_00188	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Asulf_00195	COG0039	L-malate dehydrogenase activity
Asulf_00196	COG1940	carbohydrate kinase activity
Asulf_00199	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Asulf_00201	COG0174	glutamine synthetase
Asulf_00202	COG0163	prenyltransferase activity
Asulf_00205	COG1321	iron dependent repressor
Asulf_00207	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Asulf_00211	COG2210	Belongs to the sulfur carrier protein TusA family
Asulf_00213	COG1252	NADH dehydrogenase
Asulf_00215	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Asulf_00216	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Asulf_00218	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Asulf_00220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Asulf_00222	COG0688	phosphatidylethanolamine metabolic process
Asulf_00231	COG3842	ATPase activity
Asulf_00232	COG0410	ABC transporter
Asulf_00235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Asulf_00238	COG2078	PFAM AMMECR1 domain protein
Asulf_00239	COG3118	belongs to the thioredoxin family
Asulf_00240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Asulf_00242	COG0585	pseudouridine synthase activity
Asulf_00251	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Asulf_00253	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Asulf_00257	COG0409	Hydrogenase expression formation protein
Asulf_00259	COG1592	Rubrerythrin
Asulf_00259	COG1773	rubredoxin
Asulf_00262	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Asulf_00262	COG0517	IMP dehydrogenase activity
Asulf_00269	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Asulf_00270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Asulf_00274	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Asulf_00275	COG0045	succinate-CoA ligase (ADP-forming) activity
Asulf_00282	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Asulf_00283	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Asulf_00286	COG1227	inorganic diphosphatase activity
Asulf_00287	COG1683	Conserved Protein
Asulf_00295	COG2217	Heavy metal translocating P-type atpase
Asulf_00297	COG2226	methyltransferase
Asulf_00304	COG0640	Transcriptional regulator
Asulf_00305	COG2217	Heavy metal translocating P-type atpase
Asulf_00309	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Asulf_00311	COG0137	argininosuccinate synthase activity
Asulf_00315	COG1013	pyruvate-flavodoxin oxidoreductase activity
Asulf_00316	COG0674	pyruvate-flavodoxin oxidoreductase activity
Asulf_00316	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Asulf_00319	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Asulf_00320	COG0483	inositol monophosphate 1-phosphatase activity
Asulf_00321	COG1013	pyruvate-flavodoxin oxidoreductase activity
Asulf_00326	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Asulf_00327	COG0215	cysteine-tRNA ligase activity
Asulf_00329	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Asulf_00331	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Asulf_00332	COG0560	Phosphoserine phosphatase
Asulf_00332	COG3830	Belongs to the UPF0237 family
Asulf_00334	COG0358	DNA primase activity
Asulf_00340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Asulf_00349	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Asulf_00350	COG0402	S-adenosylhomocysteine deaminase activity
Asulf_00353	COG2855	membrane
Asulf_00355	COG2855	membrane
Asulf_00358	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Asulf_00361	COG1355	regulation of microtubule-based process
Asulf_00363	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Asulf_00368	COG0419	ATPase involved in DNA repair
Asulf_00371	COG0433	COG0433 Predicted ATPase
Asulf_00372	COG1136	(ABC) transporter
Asulf_00372	COG0577	efflux transmembrane transporter activity
Asulf_00373	COG1136	(ABC) transporter
Asulf_00377	COG0543	2 iron, 2 sulfur cluster binding
Asulf_00378	COG0167	dihydroorotate dehydrogenase activity
Asulf_00383	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Asulf_00383	COG0493	'glutamate synthase
Asulf_00384	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Asulf_00386	COG4608	Belongs to the ABC transporter superfamily
Asulf_00387	COG0444	Belongs to the ABC transporter superfamily
Asulf_00389	COG0601	transmembrane transport
Asulf_00390	COG0747	negative chemotaxis
Asulf_00400	COG0730	response to heat
Asulf_00405	COG0489	protein tyrosine kinase activity
Asulf_00412	COG0538	isocitrate dehydrogenase activity
Asulf_00413	COG1606	tRNA processing
Asulf_00415	COG1691	(AIR) carboxylase
Asulf_00416	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Asulf_00417	COG0505	Belongs to the CarA family
Asulf_00419	COG2345	Transcriptional regulator
Asulf_00424	COG0281	malic enzyme
Asulf_00426	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Asulf_00429	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Asulf_00430	COG0581	inorganic phosphate transmembrane transporter activity
Asulf_00431	COG0573	inorganic phosphate transmembrane transporter activity
Asulf_00435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Asulf_00438	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Asulf_00441	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Asulf_00441	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Asulf_00447	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Asulf_00449	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Asulf_00451	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Asulf_00456	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Asulf_00458	COG0531	amino acid
Asulf_00461	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Asulf_00464	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Asulf_00470	COG0129	dihydroxy-acid dehydratase activity
Asulf_00471	COG1378	Sugar-specific transcriptional regulator TrmB
Asulf_00473	COG2409	Drug exporters of the RND superfamily
Asulf_00473	COG1033	growth of symbiont in host cell
Asulf_00477	COG0183	Belongs to the thiolase family
Asulf_00479	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Asulf_00480	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Asulf_00483	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Asulf_00487	COG1131	(ABC) transporter
Asulf_00492	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Asulf_00493	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Asulf_00498	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Asulf_00500	COG0142	geranyltranstransferase activity
Asulf_00502	COG1324	tolerance protein
Asulf_00506	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Asulf_00510	COG0511	ligase activity, forming carbon-carbon bonds
Asulf_00513	COG0346	lactoylglutathione lyase activity
Asulf_00517	COG0574	Belongs to the PEP-utilizing enzyme family
Asulf_00517	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Asulf_00520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Asulf_00523	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Asulf_00524	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Asulf_00533	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Asulf_00534	COG0142	geranyltranstransferase activity
Asulf_00540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Asulf_00544	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Asulf_00557	COG1469	GTP cyclohydrolase I activity
Asulf_00559	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Asulf_00560	COG0113	porphobilinogen synthase activity
Asulf_00561	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Asulf_00562	COG0181	hydroxymethylbilane synthase activity
Asulf_00563	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Asulf_00563	COG1648	precorrin-2 dehydrogenase activity
Asulf_00565	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Asulf_00566	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Asulf_00569	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Asulf_00577	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Asulf_00579	COG2119	membrane
Asulf_00589	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Asulf_00591	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Asulf_00594	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Asulf_00600	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
Asulf_00604	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Asulf_00606	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Asulf_00609	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Asulf_00610	COG1648	precorrin-2 dehydrogenase activity
Asulf_00610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Asulf_00616	COG0084	hydrolase, TatD family'
Asulf_00619	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Asulf_00624	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Asulf_00626	COG0475	glutathione-regulated potassium exporter activity
Asulf_00628	COG0200	Binds to the 23S rRNA
Asulf_00630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Asulf_00633	COG0148	phosphopyruvate hydratase activity
Asulf_00634	COG0052	Belongs to the universal ribosomal protein uS2 family
Asulf_00636	COG1620	l-lactate permease
Asulf_00637	COG1620	l-lactate permease
Asulf_00639	COG0277	FAD linked oxidase domain protein
Asulf_00643	COG1139	Iron-sulfur cluster binding protein
Asulf_00646	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Asulf_00648	COG0512	Glutamine amidotransferase of anthranilate synthase
Asulf_00648	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Asulf_00650	COG0133	tryptophan synthase activity
Asulf_00651	COG0159	tryptophan synthase activity
Asulf_00653	COG0124	histidyl-tRNA synthetase
Asulf_00654	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Asulf_00655	COG2855	membrane
Asulf_00656	COG0589	response to stress
Asulf_00658	COG0671	phosphoesterase, PA-phosphatase related
Asulf_00670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Asulf_00672	COG3118	belongs to the thioredoxin family
Asulf_00674	COG1245	4Fe-4S binding domain
Asulf_00674	COG2878	Part of a membrane complex involved in electron transport
Asulf_00678	COG0525	valine-tRNA ligase activity
Asulf_00686	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Asulf_00687	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Asulf_00692	COG0110	maltose O-acetyltransferase activity
Asulf_00693	COG1234	tRNA 3'-trailer cleavage
Asulf_00694	COG0051	transcription antitermination factor activity, RNA binding
Asulf_00695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Asulf_00696	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Asulf_00697	COG0049	tRNA binding
Asulf_00699	COG0195	Participates in both transcription termination and antitermination
Asulf_00701	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Asulf_00702	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Asulf_00703	COG0085	RNA polymerase activity
Asulf_00704	COG0085	RNA polymerase activity
Asulf_00704	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Asulf_00709	COG0009	L-threonylcarbamoyladenylate synthase
Asulf_00712	COG0563	adenylate kinase activity
Asulf_00716	COG0697	spore germination
Asulf_00717	COG0352	thiamine-phosphate diphosphorylase activity
Asulf_00730	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Asulf_00733	COG1891	lyase activity
Asulf_00734	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Asulf_00735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Asulf_00736	COG0131	Imidazoleglycerol-phosphate dehydratase
Asulf_00737	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Asulf_00738	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Asulf_00743	COG1185	polyribonucleotide nucleotidyltransferase activity
Asulf_00748	COG1185	polyribonucleotide nucleotidyltransferase activity
Asulf_00749	COG0784	Response regulator, receiver
Asulf_00750	COG5002	protein histidine kinase activity
Asulf_00752	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Asulf_00755	COG0477	Major facilitator Superfamily
Asulf_00756	COG2814	Major facilitator Superfamily
Asulf_00759	COG0778	Nitroreductase
Asulf_00760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Asulf_00761	COG0430	RNA-3'-phosphate cyclase activity
Asulf_00763	COG0446	pyridine nucleotide-disulphide oxidoreductase
Asulf_00767	COG1196	nuclear chromosome segregation
Asulf_00769	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Asulf_00771	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Asulf_00771	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Asulf_00772	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Asulf_00774	COG0432	Pfam Uncharacterised protein family UPF0047
Asulf_00776	COG0138	bifunctional purine biosynthesis protein purh
Asulf_00778	COG1960	acyl-CoA dehydrogenase activity
Asulf_00784	COG1584	GPR1 FUN34 yaaH family protein
Asulf_00785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Asulf_00790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Asulf_00794	COG0519	Catalyzes the synthesis of GMP from XMP
Asulf_00794	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Asulf_00795	COG0504	CTP synthase activity
Asulf_00797	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Asulf_00798	COG0343	queuine tRNA-ribosyltransferase activity
Asulf_00805	COG1111	helicase
Asulf_00805	COG1205	dead DEAH box helicase
Asulf_00806	COG0446	pyridine nucleotide-disulphide oxidoreductase
Asulf_00808	COG0303	'Molybdopterin
Asulf_00809	COG0303	'Molybdopterin
Asulf_00811	COG0351	phosphomethylpyrimidine kinase
Asulf_00811	COG0352	thiamine-phosphate diphosphorylase activity
Asulf_00812	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Asulf_00816	COG0438	transferase activity, transferring glycosyl groups
Asulf_00818	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Asulf_00822	COG0076	glutamate decarboxylase activity
Asulf_00823	COG0390	transport system, permease component
Asulf_00824	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Asulf_00825	COG1695	Transcriptional regulator
Asulf_00827	COG0534	Mate efflux family protein
Asulf_00834	COG2050	protein possibly involved in aromatic compounds catabolism
Asulf_00848	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Asulf_00856	COG0116	Belongs to the methyltransferase superfamily
Asulf_00858	COG0519	Catalyzes the synthesis of GMP from XMP
Asulf_00859	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Asulf_00859	COG1213	nucleotidyl transferase
Asulf_00861	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Asulf_00864	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Asulf_00867	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Asulf_00867	COG0045	succinate-CoA ligase (ADP-forming) activity
Asulf_00867	COG1042	CoA-binding domain protein
Asulf_00870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Asulf_00873	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Asulf_00873	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Asulf_00879	COG1013	pyruvate-flavodoxin oxidoreductase activity
Asulf_00880	COG0674	pyruvate-flavodoxin oxidoreductase activity
Asulf_00885	COG1053	succinate dehydrogenase
Asulf_00893	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Asulf_00902	COG0126	phosphoglycerate kinase activity
Asulf_00907	COG0517	IMP dehydrogenase activity
Asulf_00907	COG0516	GMP reductase activity
Asulf_00908	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Asulf_00910	COG1615	UPF0182 protein
Asulf_00912	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Asulf_00915	COG2221	Nitrite and sulphite reductase 4Fe-4S
Asulf_00916	COG2221	Nitrite and sulphite reductase 4Fe-4S
Asulf_00917	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Asulf_00921	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Asulf_00925	COG0444	Belongs to the ABC transporter superfamily
Asulf_00928	COG0601	transmembrane transport
Asulf_00929	COG0747	negative chemotaxis
Asulf_00932	COG2226	methyltransferase
Asulf_00933	COG0347	Belongs to the P(II) protein family
Asulf_00934	COG0004	ammonium transporteR
Asulf_00937	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Asulf_00940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Asulf_00941	COG1830	Aldolase
Asulf_00973	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Asulf_00973	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Asulf_00974	COG0517	IMP dehydrogenase activity
Asulf_00974	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Asulf_00975	COG0077	Prephenate dehydratase
Asulf_00975	COG1605	Chorismate mutase
Asulf_00977	COG1465	3-dehydroquinate synthase
Asulf_00978	COG1830	Aldolase
Asulf_00979	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Asulf_00980	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Asulf_00988	COG0436	Aminotransferase
Asulf_00990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Asulf_00995	COG1573	uracil-dna glycosylase
Asulf_00999	COG0252	asparaginase activity
Asulf_01001	COG2264	protein methyltransferase activity
Asulf_01003	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Asulf_01009	COG1185	polyribonucleotide nucleotidyltransferase activity
Asulf_01010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Asulf_01010	COG0140	phosphoribosyl-ATP diphosphatase activity
Asulf_01013	COG0314	molybdopterin synthase activity
Asulf_01016	COG0109	protoheme IX farnesyltransferase activity
Asulf_01018	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Asulf_01025	COG4191	Histidine kinase
Asulf_01027	COG2855	membrane
Asulf_01031	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Asulf_01032	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Asulf_01034	COG0531	amino acid
Asulf_01035	COG0668	transmembrane transport
Asulf_01041	COG0714	Associated with various cellular activities
Asulf_01047	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Asulf_01048	COG1227	inorganic diphosphatase activity
Asulf_01050	COG0306	phosphate transporter
Asulf_01052	COG1126	abc transporter atp-binding protein
Asulf_01056	COG1335	isochorismatase
Asulf_01057	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Asulf_01062	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Asulf_01063	COG0587	DNA-directed DNA polymerase activity
Asulf_01067	COG0528	UMP kinase activity
Asulf_01068	COG0495	leucyl-tRNA aminoacylation
Asulf_01069	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Asulf_01070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Asulf_01076	COG3259	Nickel-dependent hydrogenase
Asulf_01079	COG2048	Heterodisulfide reductase, subunit B
Asulf_01082	COG0589	response to stress
Asulf_01087	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Asulf_01088	COG0149	triose-phosphate isomerase activity
Asulf_01089	COG0473	3-isopropylmalate dehydrogenase activity
Asulf_01090	COG0066	3-isopropylmalate dehydratase activity
Asulf_01091	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Asulf_01092	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Asulf_01094	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Asulf_01103	COG1216	Glycosyl transferase, family 2
Asulf_01106	COG0297	glycogen (starch) synthase activity
Asulf_01106	COG0438	transferase activity, transferring glycosyl groups
Asulf_01109	COG0471	metal ion transport
Asulf_01111	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Asulf_01117	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Asulf_01122	COG3290	protein histidine kinase activity
Asulf_01123	COG0183	Belongs to the thiolase family
Asulf_01124	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Asulf_01125	COG4145	pantothenate transmembrane transporter activity
Asulf_01126	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Asulf_01128	COG1047	Peptidyl-prolyl cis-trans
Asulf_01129	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Asulf_01131	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Asulf_01132	COG0154	amidase activity
Asulf_01133	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Asulf_01135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Asulf_01138	COG1231	oxidoreductase activity
Asulf_01150	COG3794	PFAM blue (type 1) copper domain protein
Asulf_01154	COG0561	phosphatase activity
Asulf_01155	COG1960	acyl-CoA dehydrogenase activity
Asulf_01156	COG0318	PFAM AMP-dependent synthetase and ligase
Asulf_01164	COG1598	PFAM Uncharacterised protein family UPF0150
Asulf_01170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Asulf_01177	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Asulf_01188	COG1250	3-hydroxyacyl-CoA dehydrogenase
Asulf_01189	COG1024	Enoyl-CoA hydratase
Asulf_01190	COG1960	acyl-CoA dehydrogenase activity
Asulf_01194	COG0655	NAD(P)H dehydrogenase (quinone) activity
Asulf_01197	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Asulf_01198	COG1250	3-hydroxyacyl-CoA dehydrogenase
Asulf_01199	COG1522	sequence-specific DNA binding
Asulf_01200	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Asulf_01203	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Asulf_01207	COG4145	pantothenate transmembrane transporter activity
Asulf_01211	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Asulf_01212	COG1201	RNA secondary structure unwinding
Asulf_01218	COG2033	superoxide reductase activity
Asulf_01219	COG2201	protein-glutamate methylesterase activity
Asulf_01231	COG1151	hydroxylamine reductase activity
Asulf_01240	COG4608	Belongs to the ABC transporter superfamily
Asulf_01241	COG0444	Belongs to the ABC transporter superfamily
Asulf_01243	COG0601	transmembrane transport
Asulf_01244	COG0747	negative chemotaxis
Asulf_01246	COG1518	maintenance of DNA repeat elements
Asulf_01247	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Asulf_01249	COG1203	CRISPR-associated helicase, Cas3
Asulf_01259	COG0426	domain, Protein
Asulf_01261	COG1960	acyl-CoA dehydrogenase activity
Asulf_01262	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Asulf_01265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Asulf_01267	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Asulf_01271	COG2201	protein-glutamate methylesterase activity
Asulf_01279	COG1268	BioY protein
Asulf_01280	COG4172	Belongs to the ABC transporter superfamily
Asulf_01284	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Asulf_01291	COG0107	imidazoleglycerol-phosphate synthase activity
Asulf_01292	COG1254	Belongs to the acylphosphatase family
Asulf_01295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Asulf_01314	COG1846	Transcriptional regulator
Asulf_01345	COG1401	restriction endodeoxyribonuclease activity
Asulf_01351	COG0546	phosphoglycolate phosphatase activity
Asulf_01354	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Asulf_01360	COG0514	ATP-dependent DNA helicase (RecQ)
Asulf_01363	COG4637	Psort location Cytoplasmic, score
Asulf_01364	COG3335	DDE superfamily endonuclease
Asulf_01374	COG0827	DNA restriction-modification system
Asulf_01378	COG1598	PFAM Uncharacterised protein family UPF0150
Asulf_01382	COG1525	nuclease
Asulf_01420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Asulf_01421	COG1960	acyl-CoA dehydrogenase activity
Asulf_01425	COG0719	Fe-S assembly protein
Asulf_01425	COG1372	Participates in initiation and elongation during chromosome replication
Asulf_01430	COG1960	acyl-CoA dehydrogenase activity
Asulf_01431	COG0183	Belongs to the thiolase family
Asulf_01433	COG1250	3-hydroxyacyl-CoA dehydrogenase
Asulf_01439	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Asulf_01471	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Asulf_01476	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Asulf_01477	COG0315	cyclic pyranopterin monophosphate synthase activity
Asulf_01478	COG0277	FAD linked oxidase domain protein
Asulf_01479	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Asulf_01546	COG0037	tRNA processing
Asulf_01551	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Asulf_01552	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Asulf_01553	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Asulf_01553	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Asulf_01556	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Asulf_01557	COG0492	ferredoxin-NADP+ reductase activity
Asulf_01560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Asulf_01561	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Asulf_01561	COG0778	Nitroreductase
Asulf_01562	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Asulf_01563	COG3118	belongs to the thioredoxin family
Asulf_01564	COG0301	tRNA thio-modification
Asulf_01565	COG1773	rubredoxin
Asulf_01565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Asulf_01567	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Asulf_01568	COG1793	dna ligase
Asulf_01569	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Asulf_01571	COG0010	Belongs to the arginase family
Asulf_01572	COG1592	Rubrerythrin
Asulf_01574	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Asulf_01575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Asulf_01578	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Asulf_01579	COG2340	Cysteine-rich secretory protein family
Asulf_01582	COG0006	proline dipeptidase activity
Asulf_01584	COG0747	negative chemotaxis
Asulf_01585	COG0601	transmembrane transport
Asulf_01587	COG0444	Belongs to the ABC transporter superfamily
Asulf_01588	COG4608	Belongs to the ABC transporter superfamily
Asulf_01590	COG0017	Asparaginyl-tRNA synthetase
Asulf_01591	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Asulf_01600	COG1229	Formylmethanofuran dehydrogenase subunit A
Asulf_01603	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Asulf_01604	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Asulf_01605	COG0183	Belongs to the thiolase family
Asulf_01607	COG1960	acyl-CoA dehydrogenase activity
Asulf_01608	COG1250	3-hydroxyacyl-CoA dehydrogenase
Asulf_01615	COG2442	InterPro IPR007367
Asulf_01624	COG0442	prolyl-tRNA aminoacylation
Asulf_01627	COG1945	arginine decarboxylase activity
Asulf_01628	COG0531	amino acid
Asulf_01629	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Asulf_01631	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Asulf_01633	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Asulf_01636	COG1793	dna ligase
Asulf_01639	COG2181	nitrate reductase activity
Asulf_01639	COG0247	lactate metabolic process
Asulf_01641	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Asulf_01644	COG0583	DNA-binding transcription factor activity
Asulf_01652	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Asulf_01653	COG1993	acr, cog1993
Asulf_01654	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Asulf_01657	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Asulf_01660	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Asulf_01661	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Asulf_01662	COG1763	Mo-molybdopterin cofactor biosynthetic process
Asulf_01664	COG0460	homoserine dehydrogenase
Asulf_01666	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Asulf_01669	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Asulf_01670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Asulf_01671	COG3290	protein histidine kinase activity
Asulf_01672	COG5002	protein histidine kinase activity
Asulf_01673	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Asulf_01675	COG0318	PFAM AMP-dependent synthetase and ligase
Asulf_01680	COG5002	protein histidine kinase activity
Asulf_01682	COG2890	protein-(glutamine-N5) methyltransferase activity
Asulf_01683	COG0864	Transcriptional regulator
Asulf_01686	COG1522	sequence-specific DNA binding
Asulf_01687	COG1794	racemase activity, acting on amino acids and derivatives
Asulf_01688	COG2181	nitrate reductase activity
Asulf_01688	COG0247	lactate metabolic process
Asulf_01689	COG0028	Belongs to the TPP enzyme family
Asulf_01690	COG0440	acetolactate synthase activity
Asulf_01692	COG0470	DNA polymerase III
Asulf_01692	COG1067	ATP-dependent peptidase activity
Asulf_01693	COG0312	modulator of DNA gyrase
Asulf_01697	COG0463	Glycosyl transferase, family 2
Asulf_01699	COG0463	Glycosyl transferase, family 2
Asulf_01711	COG5002	protein histidine kinase activity
Asulf_01713	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Asulf_01717	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Asulf_01717	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Asulf_01725	COG0805	protein transport
Asulf_01726	COG0569	domain protein
Asulf_01730	COG1024	Enoyl-CoA hydratase
Asulf_01743	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Asulf_01744	COG0649	NAD binding
Asulf_01745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Asulf_01748	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Asulf_01749	COG0651	ATP synthesis coupled electron transport
Asulf_01754	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Asulf_01755	COG0247	lactate metabolic process
Asulf_01755	COG2181	nitrate reductase activity
Asulf_01759	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Asulf_01763	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Asulf_01764	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Asulf_01766	COG5002	protein histidine kinase activity
Asulf_01767	COG0019	diaminopimelate decarboxylase activity
Asulf_01768	COG0436	Aminotransferase
Asulf_01769	COG0372	Belongs to the citrate synthase family
Asulf_01772	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Asulf_01773	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Asulf_01774	COG0047	phosphoribosylformylglycinamidine synthase activity
Asulf_01775	COG0730	response to heat
Asulf_01784	COG0559	Belongs to the binding-protein-dependent transport system permease family
Asulf_01790	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Asulf_01791	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Asulf_01799	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Asulf_01800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Asulf_01801	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Asulf_01803	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Asulf_01804	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Asulf_01807	COG0651	ATP synthesis coupled electron transport
Asulf_01811	COG1007	ATP synthesis coupled electron transport
Asulf_01816	COG0446	pyridine nucleotide-disulphide oxidoreductase
Asulf_01820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Asulf_01820	COG1017	nitric oxide dioxygenase activity
Asulf_01823	COG0516	GMP reductase activity
Asulf_01823	COG0517	IMP dehydrogenase activity
Asulf_01834	COG1138	Cytochrome C-type biogenesis protein
Asulf_01835	COG2339	peptidase activity
Asulf_01836	COG4399	Belongs to the UPF0754 family
Asulf_01840	COG0247	lactate metabolic process
Asulf_01840	COG2181	nitrate reductase activity
Asulf_01844	COG0517	IMP dehydrogenase activity
Asulf_01844	COG1994	Peptidase M50
Asulf_01849	COG0180	Tryptophanyl-tRNA synthetase
Asulf_01851	COG1615	UPF0182 protein
Asulf_01855	COG0805	protein transport
Asulf_01856	COG2414	aldehyde ferredoxin oxidoreductase
Asulf_01861	COG0410	ABC transporter
Asulf_01865	COG2201	protein-glutamate methylesterase activity
Asulf_01871	COG2373	Large extracellular alpha-helical protein
Asulf_01872	COG1404	Belongs to the peptidase S8 family
Asulf_01873	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Asulf_01877	COG1122	ATPase activity
Asulf_01880	COG0310	cobalt ion transport
Asulf_01881	COG0436	Aminotransferase
Asulf_01883	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Asulf_01884	COG0101	tRNA pseudouridine synthase activity
Asulf_01890	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Asulf_01894	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Asulf_01896	COG0066	3-isopropylmalate dehydratase activity
Asulf_01899	COG0443	Heat shock 70 kDa protein
Asulf_01903	COG2814	Major facilitator Superfamily
Asulf_01905	COG2095	MarC family integral membrane protein
Asulf_01907	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Asulf_01910	COG1131	(ABC) transporter
Asulf_01926	COG0529	Catalyzes the synthesis of activated sulfate
Asulf_01938	COG0318	PFAM AMP-dependent synthetase and ligase
Asulf_01939	COG0187	DNA topoisomerase II activity
Asulf_01940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Asulf_01941	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Asulf_01956	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Asulf_01957	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Asulf_01961	COG0003	Pfam Anion-transporting ATPase
Asulf_01964	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Asulf_01966	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Asulf_01967	COG1234	tRNA 3'-trailer cleavage
Asulf_01971	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Asulf_01973	COG0330	HflC and HflK could
Asulf_01974	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Asulf_01977	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Asulf_01978	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Asulf_01979	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Asulf_01980	COG1850	ribulose-bisphosphate carboxylase activity
Asulf_01981	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Asulf_01982	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Asulf_01991	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Asulf_01993	COG1522	sequence-specific DNA binding
Asulf_01994	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Asulf_01996	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Asulf_01997	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Asulf_01999	COG1183	phosphatidylcholine synthase activity
Asulf_02005	COG1811	Na channel or pump
Asulf_02006	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Asulf_02013	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Asulf_02016	COG0371	Dehydrogenase
Asulf_02017	COG0501	Belongs to the peptidase M48B family
Asulf_02021	COG0154	amidase activity
Asulf_02032	COG0427	acetyl-CoA hydrolase
Asulf_02043	COG1522	sequence-specific DNA binding
Asulf_02044	COG4948	Mandelate Racemase Muconate Lactonizing
Asulf_02054	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Asulf_02060	COG0081	regulation of translation
Asulf_02063	COG0439	Biotin carboxylase
Asulf_02068	COG1378	Sugar-specific transcriptional regulator TrmB
Asulf_02069	COG1088	dTDP-glucose 4,6-dehydratase activity
Asulf_02071	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Asulf_02072	COG1331	Highly conserved protein containing a thioredoxin domain
Asulf_02074	COG0004	ammonium transporteR
Asulf_02075	COG0347	Belongs to the P(II) protein family
Asulf_02076	COG0004	ammonium transporteR
Asulf_02081	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Asulf_02083	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Asulf_02084	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Asulf_02090	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Asulf_02094	COG0708	Exodeoxyribonuclease III
Asulf_02100	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Asulf_02103	COG0521	Mo-molybdopterin cofactor biosynthetic process
Asulf_02107	COG2264	protein methyltransferase activity
Asulf_02110	COG1233	COG1233 Phytoene dehydrogenase and related
Asulf_02116	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Asulf_02117	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Asulf_02118	COG0535	radical SAM domain protein
Asulf_02121	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Asulf_02123	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Asulf_02130	COG2414	aldehyde ferredoxin oxidoreductase
Asulf_02131	COG0778	Nitroreductase
Asulf_02133	COG1418	mRNA catabolic process
Asulf_02134	COG0446	pyridine nucleotide-disulphide oxidoreductase
Asulf_02136	COG0446	pyridine nucleotide-disulphide oxidoreductase
Asulf_02139	COG0247	lactate metabolic process
Asulf_02147	COG1121	(ABC) transporter
Asulf_02148	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Asulf_02149	COG0151	Belongs to the GarS family
Asulf_02150	COG0446	pyridine nucleotide-disulphide oxidoreductase
Asulf_02150	COG1902	pentaerythritol trinitrate reductase activity
Asulf_02156	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Asulf_02157	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Asulf_02157	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Asulf_02161	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Asulf_02162	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Asulf_02166	COG1201	RNA secondary structure unwinding
Asulf_02167	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Asulf_02176	COG2201	protein-glutamate methylesterase activity
Asulf_02178	COG0517	IMP dehydrogenase activity
Asulf_02178	COG0516	GMP reductase activity
Asulf_02179	COG0517	IMP dehydrogenase activity
Asulf_02182	COG2414	aldehyde ferredoxin oxidoreductase
Asulf_02187	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Asulf_02189	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Asulf_02192	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Asulf_02193	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Asulf_02203	COG0489	protein tyrosine kinase activity
Asulf_02204	COG1342	Belongs to the UPF0251 family
Asulf_02212	COG5002	protein histidine kinase activity
Asulf_02214	COG0084	hydrolase, TatD family'
Asulf_02216	COG0045	succinate-CoA ligase (ADP-forming) activity
Asulf_02217	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Asulf_02218	COG1053	succinate dehydrogenase
Asulf_02222	COG0569	domain protein
Asulf_02222	COG2985	domain, Protein
Asulf_02228	COG1185	polyribonucleotide nucleotidyltransferase activity
Asulf_02229	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Asulf_02232	COG1773	rubredoxin
Asulf_02235	COG1492	cobalamin metabolic process
Asulf_02239	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Asulf_02240	COG1122	ATPase activity
Asulf_02245	COG2264	protein methyltransferase activity
Asulf_02247	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Asulf_02248	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Asulf_02253	COG1110	DNA topoisomerase II activity
Asulf_02259	COG0105	UTP biosynthetic process
Asulf_02260	COG3266	domain, Protein
Asulf_02260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Asulf_02262	COG2226	methyltransferase
Asulf_02264	COG0857	belongs to the CobB CobQ family
Asulf_02270	COG0746	molybdenum cofactor guanylyltransferase activity
Asulf_02271	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Asulf_02276	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Asulf_02277	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Asulf_02284	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Asulf_02285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Asulf_02291	COG0437	4 iron, 4 sulfur cluster binding
Asulf_02292	COG2920	part of a sulfur-relay system
Asulf_02300	COG1980	fructose-bisphosphate aldolase activity