locus-tag	class	description
AA314_00007	COG2319	Wd-40 repeat
AA314_00007	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_00009	COG0243	molybdopterin cofactor binding
AA314_00027	COG2124	cytochrome p450
AA314_00028	COG2124	cytochrome p450
AA314_00035	COG0456	acetyltransferase
AA314_00037	COG1131	(ABC) transporter
AA314_00039	COG1131	(ABC) transporter
AA314_00040	COG1725	Transcriptional regulator
AA314_00054	COG0515	serine threonine protein kinase
AA314_00054	COG2815	serine threonine protein kinase
AA314_00062	COG1404	Belongs to the peptidase S8 family
AA314_00070	COG1902	pentaerythritol trinitrate reductase activity
AA314_00074	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AA314_00079	COG1595	DNA-templated transcription, initiation
AA314_00081	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_00081	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_00082	COG1404	Belongs to the peptidase S8 family
AA314_00084	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AA314_00085	COG0784	Response regulator, receiver
AA314_00085	COG2205	protein histidine kinase activity
AA314_00099	COG2311	Membrane
AA314_00102	COG0242	peptide deformylase activity
AA314_00113	COG1672	PFAM Archaeal ATPase
AA314_00113	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_00119	COG3852	Histidine kinase
AA314_00129	COG2319	Wd-40 repeat
AA314_00129	COG5635	Nacht domain
AA314_00132	COG0625	glutathione transferase activity
AA314_00133	COG2223	nitrite transmembrane transporter activity
AA314_00136	COG2814	Major facilitator Superfamily
AA314_00137	COG2205	protein histidine kinase activity
AA314_00166	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AA314_00167	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AA314_00168	COG0235	Class ii aldolase
AA314_00170	COG5002	protein histidine kinase activity
AA314_00173	COG0003	Pfam Anion-transporting ATPase
AA314_00174	COG0517	IMP dehydrogenase activity
AA314_00180	COG1388	LysM domain
AA314_00183	COG0784	Response regulator, receiver
AA314_00183	COG5002	protein histidine kinase activity
AA314_00187	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AA314_00193	COG0535	radical SAM domain protein
AA314_00198	COG5002	protein histidine kinase activity
AA314_00207	COG3483	tryptophan 2,3-dioxygenase activity
AA314_00211	COG2267	carboxylic ester hydrolase activity
AA314_00212	COG0506	proline dehydrogenase activity
AA314_00224	COG0604	alcohol dehydrogenase
AA314_00225	COG1739	Uncharacterized protein family UPF0029
AA314_00229	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_00230	COG4221	oxidoreductase activity
AA314_00244	COG0437	4 iron, 4 sulfur cluster binding
AA314_00246	COG0277	FAD linked oxidase domain protein
AA314_00253	COG1876	peptidase activity
AA314_00257	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_00259	COG0583	DNA-binding transcription factor activity
AA314_00260	COG3384	dioxygenase
AA314_00263	COG1763	Mo-molybdopterin cofactor biosynthetic process
AA314_00264	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA314_00266	COG1234	tRNA 3'-trailer cleavage
AA314_00271	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA314_00281	COG3268	Saccharopine dehydrogenase
AA314_00284	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_00285	COG4999	Histidine kinase
AA314_00285	COG3850	Histidine kinase
AA314_00285	COG3437	response regulator, receiver
AA314_00285	COG2205	protein histidine kinase activity
AA314_00298	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA314_00299	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA314_00301	COG1024	Enoyl-CoA hydratase
AA314_00302	COG1846	Transcriptional regulator
AA314_00303	COG2124	cytochrome p450
AA314_00307	COG0784	Response regulator, receiver
AA314_00307	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_00313	COG0714	Associated with various cellular activities
AA314_00315	COG0483	inositol monophosphate 1-phosphatase activity
AA314_00320	COG1388	LysM domain
AA314_00320	COG3584	3D domain protein
AA314_00321	COG3501	Rhs element vgr protein
AA314_00325	COG3501	Rhs element vgr protein
AA314_00330	COG0840	transmembrane signaling receptor activity
AA314_00330	COG3290	protein histidine kinase activity
AA314_00331	COG0656	L-ascorbic acid biosynthetic process
AA314_00335	COG3034	peptidoglycan biosynthetic process
AA314_00342	COG0697	spore germination
AA314_00349	COG1940	carbohydrate kinase activity
AA314_00352	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AA314_00355	COG4991	sh3 domain protein
AA314_00355	COG0515	serine threonine protein kinase
AA314_00355	COG3064	Membrane
AA314_00369	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_00386	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA314_00386	COG1845	cytochrome c oxidase, subunit III
AA314_00393	COG0437	4 iron, 4 sulfur cluster binding
AA314_00401	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AA314_00404	COG0405	Gamma-glutamyltransferase
AA314_00408	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_00409	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AA314_00410	COG2186	Transcriptional regulator
AA314_00414	COG3174	membrane
AA314_00417	COG1475	DNA binding
AA314_00418	COG1192	Involved in chromosome partitioning
AA314_00420	COG4191	Histidine kinase
AA314_00421	COG0357	Ribosomal RNA small subunit methyltransferase G
AA314_00422	COG0445	tRNA wobble uridine modification
AA314_00424	COG1879	ABC-type sugar transport system periplasmic component
AA314_00425	COG2226	methyltransferase
AA314_00430	COG0666	response to abiotic stimulus
AA314_00432	COG0612	Peptidase, M16
AA314_00433	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_00435	COG2267	carboxylic ester hydrolase activity
AA314_00437	COG0616	signal peptide processing
AA314_00448	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA314_00453	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA314_00454	COG0594	ribonuclease P activity
AA314_00455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AA314_00456	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA314_00467	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA314_00471	COG2124	cytochrome p450
AA314_00472	COG2226	methyltransferase
AA314_00473	COG4191	Histidine kinase
AA314_00486	COG1733	regulation of RNA biosynthetic process
AA314_00487	COG0702	epimerase
AA314_00490	COG2814	Major facilitator Superfamily
AA314_00492	COG2843	Capsule synthesis protein
AA314_00504	COG3209	COG3209 Rhs family protein
AA314_00506	COG0477	Major facilitator Superfamily
AA314_00507	COG0583	DNA-binding transcription factor activity
AA314_00508	COG3214	Protein conserved in bacteria
AA314_00513	COG3852	Histidine kinase
AA314_00514	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AA314_00518	COG3005	denitrification pathway
AA314_00519	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AA314_00523	COG0189	ligase activity
AA314_00528	COG0515	serine threonine protein kinase
AA314_00534	COG1562	ergosterol biosynthetic process
AA314_00535	COG0667	Aldo Keto reductase
AA314_00536	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_00538	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_00540	COG0515	serine threonine protein kinase
AA314_00554	COG0515	serine threonine protein kinase
AA314_00563	COG3387	PFAM Glycoside hydrolase 15-related
AA314_00565	COG3220	belongs to the UPF0276 family
AA314_00567	COG2319	Wd-40 repeat
AA314_00567	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_00569	COG4804	nuclease activity
AA314_00584	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AA314_00596	COG1994	Peptidase M50
AA314_00598	COG2234	aminopeptidase activity
AA314_00616	COG1690	Belongs to the RtcB family
AA314_00618	COG1819	glycosyl
AA314_00622	COG2815	serine threonine protein kinase
AA314_00622	COG0515	serine threonine protein kinase
AA314_00636	COG4771	TonB-dependent receptor
AA314_00638	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_00642	COG0515	serine threonine protein kinase
AA314_00642	COG2815	serine threonine protein kinase
AA314_00645	COG3781	membrane
AA314_00647	COG0823	Involved in the tonB-independent uptake of proteins
AA314_00647	COG1506	peptidase
AA314_00647	COG4946	Tricorn protease homolog
AA314_00654	COG0154	amidase activity
AA314_00663	COG0515	serine threonine protein kinase
AA314_00663	COG2815	serine threonine protein kinase
AA314_00667	COG1045	serine acetyltransferase
AA314_00671	COG2239	Acts as a magnesium transporter
AA314_00674	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_00676	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA314_00677	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA314_00677	COG1877	trehalose-phosphatase activity
AA314_00680	COG2124	cytochrome p450
AA314_00682	COG3387	PFAM Glycoside hydrolase 15-related
AA314_00685	COG1404	Belongs to the peptidase S8 family
AA314_00687	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_00689	COG3173	Aminoglycoside phosphotransferase
AA314_00693	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA314_00700	COG0535	radical SAM domain protein
AA314_00701	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_00701	COG4191	Histidine kinase
AA314_00704	COG0297	glycogen (starch) synthase activity
AA314_00708	COG5002	protein histidine kinase activity
AA314_00709	COG5002	protein histidine kinase activity
AA314_00711	COG0281	malic enzyme
AA314_00712	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA314_00722	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AA314_00723	COG0346	lactoylglutathione lyase activity
AA314_00726	COG4191	Histidine kinase
AA314_00726	COG0745	RESPONSE REGULATOR receiver
AA314_00726	COG2205	protein histidine kinase activity
AA314_00733	COG3540	Alkaline phosphatase
AA314_00735	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_00735	COG1672	PFAM Archaeal ATPase
AA314_00736	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA314_00757	COG0673	inositol 2-dehydrogenase activity
AA314_00759	COG4191	Histidine kinase
AA314_00762	COG5000	phosphorelay sensor kinase activity
AA314_00768	COG0596	Alpha beta hydrolase
AA314_00769	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_00775	COG4221	oxidoreductase activity
AA314_00783	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA314_00791	COG1309	transcriptional regulator
AA314_00792	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AA314_00795	COG4191	Histidine kinase
AA314_00804	COG4191	Histidine kinase
AA314_00805	COG2204	response regulator
AA314_00813	COG3228	Belongs to the MtfA family
AA314_00814	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA314_00816	COG3268	Saccharopine dehydrogenase
AA314_00820	COG0730	response to heat
AA314_00821	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA314_00824	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA314_00827	COG0435	Glutathione S-transferase
AA314_00847	COG5002	protein histidine kinase activity
AA314_00848	COG2205	protein histidine kinase activity
AA314_00848	COG5002	protein histidine kinase activity
AA314_00848	COG0784	Response regulator, receiver
AA314_00850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA314_00851	COG2271	Major facilitator Superfamily
AA314_00852	COG0596	Alpha beta hydrolase
AA314_00855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA314_00859	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_00861	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_00862	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_00865	COG2267	carboxylic ester hydrolase activity
AA314_00878	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA314_00881	COG2137	regulation of response to DNA damage stimulus
AA314_00882	COG1960	acyl-CoA dehydrogenase activity
AA314_00890	COG0840	transmembrane signaling receptor activity
AA314_00892	COG5002	protein histidine kinase activity
AA314_00892	COG0784	Response regulator, receiver
AA314_00893	COG5002	protein histidine kinase activity
AA314_00893	COG0784	Response regulator, receiver
AA314_00893	COG2205	protein histidine kinase activity
AA314_00899	COG3220	belongs to the UPF0276 family
AA314_00905	COG4191	Histidine kinase
AA314_00909	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_00910	COG0592	DNA-directed DNA polymerase activity
AA314_00912	COG2205	protein histidine kinase activity
AA314_00914	COG0515	serine threonine protein kinase
AA314_00914	COG2815	serine threonine protein kinase
AA314_00918	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA314_00919	COG3550	peptidyl-serine autophosphorylation
AA314_00921	COG3186	Phenylalanine-4-hydroxylase
AA314_00925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_00927	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_00934	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA314_00935	COG1127	ABC transporter
AA314_00939	COG2207	Transcriptional regulator
AA314_00940	COG4221	oxidoreductase activity
AA314_00945	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_00952	COG3387	PFAM Glycoside hydrolase 15-related
AA314_00953	COG4106	trans-aconitate 2-methyltransferase activity
AA314_00958	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AA314_00968	COG2205	protein histidine kinase activity
AA314_00968	COG2202	Pas domain
AA314_00969	COG0784	Response regulator, receiver
AA314_00975	COG0515	serine threonine protein kinase
AA314_00983	COG2205	protein histidine kinase activity
AA314_00983	COG2202	Pas domain
AA314_00986	COG0848	biopolymer transport protein
AA314_00991	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA314_00995	COG2181	nitrate reductase activity
AA314_00995	COG0247	lactate metabolic process
AA314_01004	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_01012	COG2204	response regulator
AA314_01013	COG0515	serine threonine protein kinase
AA314_01015	COG4638	Rieske (2fe-2S)
AA314_01017	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA314_01022	COG2205	protein histidine kinase activity
AA314_01025	COG1012	belongs to the aldehyde dehydrogenase family
AA314_01033	COG1573	uracil-dna glycosylase
AA314_01036	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_01036	COG0784	Response regulator, receiver
AA314_01039	COG0484	heat shock protein binding
AA314_01040	COG0443	Heat shock 70 kDa protein
AA314_01041	COG0515	serine threonine protein kinase
AA314_01046	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_01047	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_01048	COG2197	response regulator
AA314_01057	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_01065	COG0596	Alpha beta hydrolase
AA314_01068	COG2124	cytochrome p450
AA314_01075	COG0640	Transcriptional regulator
AA314_01079	COG1695	Transcriptional regulator
AA314_01081	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AA314_01082	COG1793	dna ligase
AA314_01111	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_01113	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA314_01119	COG1671	Belongs to the UPF0178 family
AA314_01123	COG0784	Response regulator, receiver
AA314_01123	COG4191	Histidine kinase
AA314_01125	COG0584	glycerophosphoryl diester phosphodiesterase
AA314_01126	COG0823	Involved in the tonB-independent uptake of proteins
AA314_01126	COG1506	peptidase
AA314_01126	COG4946	Tricorn protease homolog
AA314_01127	COG0235	Class ii aldolase
AA314_01128	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AA314_01129	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AA314_01130	COG4974	Belongs to the 'phage' integrase family
AA314_01131	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_01133	COG0583	DNA-binding transcription factor activity
AA314_01143	COG0753	catalase activity
AA314_01145	COG2155	Conserved Protein
AA314_01146	COG3850	Histidine kinase
AA314_01146	COG3437	response regulator, receiver
AA314_01146	COG4999	Histidine kinase
AA314_01146	COG2205	protein histidine kinase activity
AA314_01147	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA314_01159	COG0189	ligase activity
AA314_01159	COG0569	domain protein
AA314_01160	COG2204	response regulator
AA314_01165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA314_01166	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA314_01168	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA314_01169	COG4221	oxidoreductase activity
AA314_01176	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA314_01177	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA314_01178	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA314_01181	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AA314_01187	COG1846	Transcriptional regulator
AA314_01188	COG2329	Antibiotic biosynthesis monooxygenase
AA314_01193	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA314_01194	COG0515	serine threonine protein kinase
AA314_01195	COG1366	Belongs to the anti-sigma-factor antagonist family
AA314_01196	COG1366	Belongs to the anti-sigma-factor antagonist family
AA314_01197	COG2172	sigma factor antagonist activity
AA314_01201	COG3409	Peptidoglycan-binding domain 1 protein
AA314_01201	COG3773	Cell wall hydrolase
AA314_01202	COG0667	Aldo Keto reductase
AA314_01210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA314_01217	COG1515	deoxyribonuclease V activity
AA314_01218	COG0596	Alpha beta hydrolase
AA314_01224	COG0515	serine threonine protein kinase
AA314_01224	COG0457	Tetratricopeptide repeat
AA314_01226	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_01233	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA314_01233	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA314_01234	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA314_01234	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA314_01235	COG2010	Cytochrome c
AA314_01245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA314_01250	COG1595	DNA-templated transcription, initiation
AA314_01256	COG3852	Histidine kinase
AA314_01258	COG1881	PFAM PEBP family protein
AA314_01259	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AA314_01266	COG0356	it plays a direct role in the translocation of protons across the membrane
AA314_01268	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA314_01269	COG0012	GTP binding
AA314_01271	COG0372	Belongs to the citrate synthase family
AA314_01272	COG2264	protein methyltransferase activity
AA314_01278	COG1408	metallophosphoesterase
AA314_01284	COG0667	Aldo Keto reductase
AA314_01285	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_01290	COG1672	PFAM Archaeal ATPase
AA314_01290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_01295	COG0644	oxidoreductase
AA314_01300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA314_01303	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA314_01323	COG3850	Histidine kinase
AA314_01323	COG3437	response regulator, receiver
AA314_01323	COG2205	protein histidine kinase activity
AA314_01323	COG4999	Histidine kinase
AA314_01329	COG3852	Histidine kinase
AA314_01334	COG0662	Cupin 2, conserved barrel domain protein
AA314_01336	COG3844	kynureninase activity
AA314_01337	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_01338	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_01344	COG1073	alpha beta
AA314_01347	COG0166	Belongs to the GPI family
AA314_01353	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_01353	COG2319	Wd-40 repeat
AA314_01363	COG0346	lactoylglutathione lyase activity
AA314_01371	COG0386	Belongs to the glutathione peroxidase family
AA314_01374	COG4325	translation initiation factor activity
AA314_01375	COG2843	Capsule synthesis protein
AA314_01382	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_01386	COG3387	PFAM Glycoside hydrolase 15-related
AA314_01388	COG1126	abc transporter atp-binding protein
AA314_01418	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA314_01419	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA314_01420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA314_01425	COG2827	Endonuclease containing a URI domain
AA314_01426	COG4191	Histidine kinase
AA314_01430	COG0602	queuosine metabolic process
AA314_01431	COG2816	NAD+ diphosphatase activity
AA314_01433	COG1132	(ABC) transporter
AA314_01434	COG1132	(ABC) transporter
AA314_01438	COG0515	serine threonine protein kinase
AA314_01439	COG4771	TonB-dependent receptor
AA314_01443	COG0745	RESPONSE REGULATOR receiver
AA314_01444	COG0515	serine threonine protein kinase
AA314_01444	COG2815	serine threonine protein kinase
AA314_01447	COG1360	Flagellar Motor Protein
AA314_01455	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_01456	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA314_01459	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_01461	COG5002	protein histidine kinase activity
AA314_01466	COG4251	negative regulation of phosphorylation
AA314_01477	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA314_01477	COG0551	DNA topoisomerase type I activity
AA314_01479	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_01484	COG0739	heme binding
AA314_01484	COG0741	lytic transglycosylase activity
AA314_01484	COG1196	nuclear chromosome segregation
AA314_01490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA314_01493	COG0784	Response regulator, receiver
AA314_01493	COG4191	Histidine kinase
AA314_01494	COG2252	PERMEase
AA314_01495	COG1278	Cold shock
AA314_01498	COG4251	negative regulation of phosphorylation
AA314_01508	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA314_01510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_01511	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_01512	COG0515	serine threonine protein kinase
AA314_01513	COG0842	Transport permease protein
AA314_01514	COG1131	(ABC) transporter
AA314_01515	COG0488	(ABC) transporter
AA314_01522	COG1525	nuclease
AA314_01527	COG0640	Transcriptional regulator
AA314_01534	COG1125	glycine betaine transport
AA314_01534	COG0517	IMP dehydrogenase activity
AA314_01535	COG1174	glycine betaine transport
AA314_01538	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA314_01538	COG0574	Belongs to the PEP-utilizing enzyme family
AA314_01542	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA314_01543	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_01544	COG0109	protoheme IX farnesyltransferase activity
AA314_01544	COG1612	heme a metabolic process
AA314_01550	COG1012	belongs to the aldehyde dehydrogenase family
AA314_01554	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA314_01557	COG0671	phosphoesterase, PA-phosphatase related
AA314_01562	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA314_01566	COG3852	Histidine kinase
AA314_01567	COG2204	response regulator
AA314_01569	COG0110	maltose O-acetyltransferase activity
AA314_01570	COG5002	protein histidine kinase activity
AA314_01574	COG3265	gluconokinase activity
AA314_01578	COG1309	transcriptional regulator
AA314_01580	COG4191	Histidine kinase
AA314_01592	COG1192	Involved in chromosome partitioning
AA314_01598	COG1131	(ABC) transporter
AA314_01607	COG2205	protein histidine kinase activity
AA314_01610	COG5002	protein histidine kinase activity
AA314_01614	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_01617	COG1764	response to oxidative stress
AA314_01619	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_01625	COG0515	serine threonine protein kinase
AA314_01627	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AA314_01633	COG0596	Alpha beta hydrolase
AA314_01636	COG1234	tRNA 3'-trailer cleavage
AA314_01638	COG1309	transcriptional regulator
AA314_01639	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_01646	COG1278	Cold shock
AA314_01649	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AA314_01651	COG2031	fatty acid transporter
AA314_01655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA314_01656	COG0745	RESPONSE REGULATOR receiver
AA314_01657	COG5002	protein histidine kinase activity
AA314_01659	COG2197	response regulator
AA314_01661	COG2205	protein histidine kinase activity
AA314_01661	COG4999	Histidine kinase
AA314_01661	COG3437	response regulator, receiver
AA314_01661	COG3850	Histidine kinase
AA314_01665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_01668	COG2205	protein histidine kinase activity
AA314_01672	COG1132	(ABC) transporter
AA314_01674	COG0484	heat shock protein binding
AA314_01677	COG0515	serine threonine protein kinase
AA314_01696	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AA314_01699	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA314_01705	COG0644	oxidoreductase
AA314_01714	COG2130	NADP-dependent
AA314_01715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA314_01726	COG0438	transferase activity, transferring glycosyl groups
AA314_01728	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AA314_01729	COG0583	DNA-binding transcription factor activity
AA314_01730	COG0210	DNA helicase
AA314_01740	COG3227	Zinc metalloprotease (Elastase)
AA314_01744	COG1960	acyl-CoA dehydrogenase activity
AA314_01748	COG4772	TonB-dependent receptor
AA314_01750	COG4251	negative regulation of phosphorylation
AA314_01751	COG0784	Response regulator, receiver
AA314_01752	COG5002	protein histidine kinase activity
AA314_01761	COG0189	ligase activity
AA314_01761	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA314_01762	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA314_01763	COG4242	Belongs to the peptidase S51 family
AA314_01767	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_01771	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA314_01783	COG0287	Prephenate dehydrogenase
AA314_01783	COG1605	Chorismate mutase
AA314_01788	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_01792	COG2124	cytochrome p450
AA314_01797	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_01809	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA314_01810	COG1522	sequence-specific DNA binding
AA314_01827	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_01830	COG2234	aminopeptidase activity
AA314_01831	COG0242	peptide deformylase activity
AA314_01834	COG0443	Heat shock 70 kDa protein
AA314_01837	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA314_01839	COG0625	glutathione transferase activity
AA314_01841	COG0783	Belongs to the Dps family
AA314_01842	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AA314_01861	COG1309	transcriptional regulator
AA314_01862	COG1408	metallophosphoesterase
AA314_01863	COG1090	epimerase
AA314_01867	COG1562	ergosterol biosynthetic process
AA314_01869	COG1233	COG1233 Phytoene dehydrogenase and related
AA314_01880	COG3104	oligopeptide transport
AA314_01881	COG0028	Belongs to the TPP enzyme family
AA314_01885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA314_01889	COG0516	GMP reductase activity
AA314_01889	COG0517	IMP dehydrogenase activity
AA314_01892	COG3425	synthase
AA314_01893	COG3361	conserved protein (COG2071)
AA314_01895	COG0515	serine threonine protein kinase
AA314_01896	COG4191	Histidine kinase
AA314_01905	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA314_01909	COG0515	serine threonine protein kinase
AA314_01912	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA314_01916	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA314_01917	COG3002	Belongs to the UPF0753 family
AA314_01918	COG0659	secondary active sulfate transmembrane transporter activity
AA314_01919	COG1595	DNA-templated transcription, initiation
AA314_01922	COG2204	response regulator
AA314_01928	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_01930	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AA314_01931	COG0363	glucosamine-6-phosphate deaminase activity
AA314_01932	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA314_01934	COG0515	serine threonine protein kinase
AA314_01938	COG2319	Wd-40 repeat
AA314_01938	COG5635	Nacht domain
AA314_01941	COG1668	transmembrane transport
AA314_01942	COG4555	ABC transporter
AA314_01954	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_01964	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_01966	COG0420	3'-5' exonuclease activity
AA314_01983	COG1335	isochorismatase
AA314_01984	COG1522	sequence-specific DNA binding
AA314_01989	COG1309	transcriptional regulator
AA314_01990	COG0596	Alpha beta hydrolase
AA314_02004	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_02006	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AA314_02007	COG4181	ATPase activity
AA314_02010	COG2072	flavoprotein involved in K transport
AA314_02021	COG1846	Transcriptional regulator
AA314_02022	COG2085	NADP oxidoreductase coenzyme F420-dependent
AA314_02024	COG2814	Major facilitator Superfamily
AA314_02025	COG0583	DNA-binding transcription factor activity
AA314_02028	COG2198	Histidine kinase
AA314_02028	COG0643	Histidine kinase
AA314_02030	COG0745	RESPONSE REGULATOR receiver
AA314_02031	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA314_02038	COG1858	cytochrome C peroxidase
AA314_02055	COG1201	RNA secondary structure unwinding
AA314_02059	COG0395	ABC-type sugar transport system, permease component
AA314_02061	COG3842	ATPase activity
AA314_02064	COG1404	Belongs to the peptidase S8 family
AA314_02066	COG4251	negative regulation of phosphorylation
AA314_02067	COG0784	Response regulator, receiver
AA314_02068	COG2205	protein histidine kinase activity
AA314_02078	COG0601	transmembrane transport
AA314_02093	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AA314_02099	COG3706	GGDEF domain
AA314_02101	COG1360	Flagellar Motor Protein
AA314_02104	COG0419	ATPase involved in DNA repair
AA314_02114	COG0489	protein tyrosine kinase activity
AA314_02118	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA314_02123	COG0438	transferase activity, transferring glycosyl groups
AA314_02128	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA314_02131	COG0438	transferase activity, transferring glycosyl groups
AA314_02132	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA314_02137	COG2311	Membrane
AA314_02141	COG2319	Wd-40 repeat
AA314_02141	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_02144	COG0596	Alpha beta hydrolase
AA314_02145	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_02150	COG3724	N-succinylarginine dihydrolase activity
AA314_02151	COG1560	Kdo2-lipid A biosynthetic process
AA314_02154	COG1137	ATPase activity
AA314_02157	COG0438	transferase activity, transferring glycosyl groups
AA314_02158	COG2130	NADP-dependent
AA314_02160	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_02185	COG1388	LysM domain
AA314_02185	COG3942	CHAP domain
AA314_02188	COG0625	glutathione transferase activity
AA314_02193	COG0515	serine threonine protein kinase
AA314_02204	COG2304	oxidoreductase activity
AA314_02214	COG0515	serine threonine protein kinase
AA314_02220	COG0515	serine threonine protein kinase
AA314_02220	COG2815	serine threonine protein kinase
AA314_02221	COG0515	serine threonine protein kinase
AA314_02221	COG2815	serine threonine protein kinase
AA314_02223	COG5549	protein import
AA314_02223	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_02234	COG4191	Histidine kinase
AA314_02236	COG2205	protein histidine kinase activity
AA314_02238	COG5002	protein histidine kinase activity
AA314_02239	COG5002	protein histidine kinase activity
AA314_02241	COG1472	Belongs to the glycosyl hydrolase 3 family
AA314_02243	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA314_02243	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AA314_02243	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AA314_02244	COG1490	D-aminoacyl-tRNA deacylase activity
AA314_02256	COG0629	single-stranded DNA binding
AA314_02257	COG2009	succinate dehydrogenase
AA314_02258	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AA314_02259	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA314_02261	COG4191	Histidine kinase
AA314_02262	COG2204	response regulator
AA314_02263	COG0456	acetyltransferase
AA314_02264	COG1007	ATP synthesis coupled electron transport
AA314_02266	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA314_02267	COG0713	ATP synthesis coupled electron transport
AA314_02268	COG0839	Belongs to the complex I subunit 6 family
AA314_02272	COG2815	serine threonine protein kinase
AA314_02272	COG0515	serine threonine protein kinase
AA314_02273	COG0560	Phosphoserine phosphatase
AA314_02273	COG3830	Belongs to the UPF0237 family
AA314_02277	COG0071	Belongs to the small heat shock protein (HSP20) family
AA314_02279	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AA314_02280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AA314_02281	COG0504	CTP synthase activity
AA314_02283	COG1132	(ABC) transporter
AA314_02284	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AA314_02291	COG0564	pseudouridine synthase activity
AA314_02303	COG0501	Belongs to the peptidase M48B family
AA314_02306	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_02307	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_02310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA314_02313	COG0484	heat shock protein binding
AA314_02322	COG1703	isobutyryl-CoA mutase activity
AA314_02323	COG0511	ligase activity, forming carbon-carbon bonds
AA314_02323	COG5016	pyruvate
AA314_02324	COG0439	Biotin carboxylase
AA314_02326	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA314_02329	COG2267	carboxylic ester hydrolase activity
AA314_02330	COG0339	signal peptide processing
AA314_02336	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA314_02337	COG2264	protein methyltransferase activity
AA314_02341	COG0515	serine threonine protein kinase
AA314_02346	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA314_02348	COG2204	response regulator
AA314_02355	COG4191	Histidine kinase
AA314_02358	COG1714	RDD family
AA314_02360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AA314_02366	COG2264	protein methyltransferase activity
AA314_02372	COG3344	reverse transcriptase
AA314_02373	COG0612	Peptidase, M16
AA314_02376	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA314_02385	COG2124	cytochrome p450
AA314_02391	COG0300	oxidoreductase activity
AA314_02392	COG1959	2 iron, 2 sulfur cluster binding
AA314_02393	COG0719	Fe-S assembly protein
AA314_02394	COG0396	ATPase activity
AA314_02395	COG0719	Fe-S assembly protein
AA314_02397	COG0822	iron-sulfur transferase activity
AA314_02398	COG2151	metal-sulfur cluster biosynthetic enzyme
AA314_02401	COG1024	Enoyl-CoA hydratase
AA314_02406	COG0515	serine threonine protein kinase
AA314_02406	COG2815	serine threonine protein kinase
AA314_02407	COG0514	ATP-dependent DNA helicase (RecQ)
AA314_02410	COG1696	Membrane protein involved in D-alanine export
AA314_02411	COG1309	transcriptional regulator
AA314_02412	COG1136	(ABC) transporter
AA314_02412	COG0577	efflux transmembrane transporter activity
AA314_02413	COG0577	efflux transmembrane transporter activity
AA314_02413	COG1136	(ABC) transporter
AA314_02416	COG1136	(ABC) transporter
AA314_02416	COG0577	efflux transmembrane transporter activity
AA314_02420	COG2204	response regulator
AA314_02421	COG2204	response regulator
AA314_02422	COG0432	Pfam Uncharacterised protein family UPF0047
AA314_02430	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA314_02431	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_02443	COG0515	serine threonine protein kinase
AA314_02448	COG0633	Ferredoxin
AA314_02450	COG2814	Major facilitator Superfamily
AA314_02454	COG2124	cytochrome p450
AA314_02460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_02464	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_02466	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_02467	COG2124	cytochrome p450
AA314_02479	COG4251	negative regulation of phosphorylation
AA314_02487	COG4191	Histidine kinase
AA314_02492	COG0205	6-phosphofructokinase activity
AA314_02494	COG0625	glutathione transferase activity
AA314_02495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AA314_02497	COG1690	Belongs to the RtcB family
AA314_02498	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AA314_02505	COG2204	response regulator
AA314_02509	COG0667	Aldo Keto reductase
AA314_02511	COG2205	protein histidine kinase activity
AA314_02513	COG4251	negative regulation of phosphorylation
AA314_02514	COG3852	Histidine kinase
AA314_02517	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AA314_02519	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AA314_02520	COG0156	8-amino-7-oxononanoate synthase activity
AA314_02521	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AA314_02523	COG0436	Aminotransferase
AA314_02525	COG0784	Response regulator, receiver
AA314_02526	COG1297	OPT oligopeptide transporter protein
AA314_02528	COG0840	transmembrane signaling receptor activity
AA314_02530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA314_02530	COG4221	oxidoreductase activity
AA314_02530	COG0300	oxidoreductase activity
AA314_02530	COG3321	synthase
AA314_02533	COG2165	general secretion pathway protein
AA314_02537	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AA314_02538	COG3273	potassium ion transport
AA314_02538	COG0471	metal ion transport
AA314_02543	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA314_02545	COG3852	Histidine kinase
AA314_02546	COG2205	protein histidine kinase activity
AA314_02546	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_02548	COG0644	oxidoreductase
AA314_02551	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA314_02558	COG3279	Response regulator of the LytR AlgR family
AA314_02566	COG1201	RNA secondary structure unwinding
AA314_02568	COG1793	dna ligase
AA314_02572	COG0564	pseudouridine synthase activity
AA314_02575	COG1940	carbohydrate kinase activity
AA314_02583	COG3275	phosphorelay sensor kinase activity
AA314_02588	COG0297	glycogen (starch) synthase activity
AA314_02589	COG0515	serine threonine protein kinase
AA314_02589	COG2815	serine threonine protein kinase
AA314_02596	COG4651	solute:proton antiporter activity
AA314_02596	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA314_02603	COG4191	Histidine kinase
AA314_02604	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AA314_02614	COG4191	Histidine kinase
AA314_02616	COG2124	cytochrome p450
AA314_02621	COG5464	transposase or invertase
AA314_02631	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_02631	COG0784	Response regulator, receiver
AA314_02632	COG0402	S-adenosylhomocysteine deaminase activity
AA314_02634	COG2339	peptidase activity
AA314_02637	COG1073	alpha beta
AA314_02640	COG1611	Belongs to the LOG family
AA314_02642	COG1228	amidohydrolase
AA314_02650	COG0745	RESPONSE REGULATOR receiver
AA314_02651	COG5002	protein histidine kinase activity
AA314_02653	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AA314_02656	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AA314_02660	COG1716	ATPase activity
AA314_02661	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_02664	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA314_02667	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AA314_02669	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA314_02670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA314_02674	COG1741	Belongs to the pirin family
AA314_02676	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_02684	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_02687	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_02689	COG2755	lipolytic protein G-D-S-L family
AA314_02689	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA314_02691	COG2304	oxidoreductase activity
AA314_02694	COG3119	arylsulfatase activity
AA314_02696	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA314_02700	COG2267	carboxylic ester hydrolase activity
AA314_02704	COG1131	(ABC) transporter
AA314_02711	COG0405	Gamma-glutamyltransferase
AA314_02713	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA314_02714	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA314_02715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA314_02717	COG0515	serine threonine protein kinase
AA314_02734	COG2723	6-phospho-beta-galactosidase activity
AA314_02735	COG4608	Belongs to the ABC transporter superfamily
AA314_02736	COG0444	Belongs to the ABC transporter superfamily
AA314_02737	COG0601	transmembrane transport
AA314_02743	COG2124	cytochrome p450
AA314_02745	COG0183	Belongs to the thiolase family
AA314_02750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA314_02751	COG4948	Mandelate Racemase Muconate Lactonizing
AA314_02756	COG0438	transferase activity, transferring glycosyl groups
AA314_02758	COG1115	amino acid carrier protein
AA314_02763	COG2183	response to ionizing radiation
AA314_02765	COG4191	Histidine kinase
AA314_02765	COG0784	Response regulator, receiver
AA314_02767	COG0667	Aldo Keto reductase
AA314_02771	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_02777	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA314_02778	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA314_02779	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_02779	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_02786	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA314_02787	COG5002	protein histidine kinase activity
AA314_02794	COG0515	serine threonine protein kinase
AA314_02797	COG0248	Ppx GppA phosphatase
AA314_02798	COG2272	Belongs to the type-B carboxylesterase lipase family
AA314_02809	COG0515	serine threonine protein kinase
AA314_02811	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_02811	COG0784	Response regulator, receiver
AA314_02812	COG0604	alcohol dehydrogenase
AA314_02812	COG3321	synthase
AA314_02812	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_02817	COG1960	acyl-CoA dehydrogenase activity
AA314_02819	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA314_02820	COG2205	protein histidine kinase activity
AA314_02834	COG3290	protein histidine kinase activity
AA314_02835	COG0513	Belongs to the DEAD box helicase family
AA314_02839	COG1819	glycosyl
AA314_02841	COG0840	transmembrane signaling receptor activity
AA314_02847	COG0515	serine threonine protein kinase
AA314_02853	COG0564	pseudouridine synthase activity
AA314_02864	COG4566	intracellular signal transduction
AA314_02865	COG4191	Histidine kinase
AA314_02868	COG1215	transferase activity, transferring glycosyl groups
AA314_02872	COG0495	leucyl-tRNA aminoacylation
AA314_02873	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_02877	COG0398	Pfam SNARE associated Golgi protein
AA314_02880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AA314_02881	COG0484	heat shock protein binding
AA314_02883	COG0242	peptide deformylase activity
AA314_02884	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA314_02885	COG0739	heme binding
AA314_02886	COG0776	regulation of translation
AA314_02888	COG1183	phosphatidylcholine synthase activity
AA314_02889	COG1058	Belongs to the CinA family
AA314_02889	COG1546	Belongs to the CinA family
AA314_02893	COG0204	Acyl-transferase
AA314_02894	COG1252	NADH dehydrogenase
AA314_02912	COG0116	Belongs to the methyltransferase superfamily
AA314_02912	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA314_02917	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA314_02918	COG0154	amidase activity
AA314_02919	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA314_02920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_02928	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA314_02929	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA314_02930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA314_02931	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA314_02934	COG0515	serine threonine protein kinase
AA314_02934	COG0457	Tetratricopeptide repeat
AA314_02937	COG4221	oxidoreductase activity
AA314_02938	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA314_02940	COG1666	GTP binding
AA314_02941	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AA314_02945	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_02952	COG5002	protein histidine kinase activity
AA314_02952	COG3850	Histidine kinase
AA314_02959	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA314_02965	COG1072	(Pantothenic acid kinase))
AA314_02967	COG1090	epimerase
AA314_02970	COG5002	protein histidine kinase activity
AA314_02972	COG0596	Alpha beta hydrolase
AA314_02978	COG5002	protein histidine kinase activity
AA314_02979	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_02979	COG0204	Acyl-transferase
AA314_03007	COG4251	negative regulation of phosphorylation
AA314_03009	COG2205	protein histidine kinase activity
AA314_03015	COG0848	biopolymer transport protein
AA314_03019	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA314_03021	COG2205	protein histidine kinase activity
AA314_03021	COG0784	Response regulator, receiver
AA314_03023	COG0784	Response regulator, receiver
AA314_03023	COG2205	protein histidine kinase activity
AA314_03029	COG0702	epimerase
AA314_03037	COG0625	glutathione transferase activity
AA314_03040	COG2819	hydrolase of the alpha beta superfamily
AA314_03045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA314_03047	COG5002	protein histidine kinase activity
AA314_03048	COG2205	protein histidine kinase activity
AA314_03051	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA314_03052	COG3706	GGDEF domain
AA314_03052	COG0745	RESPONSE REGULATOR receiver
AA314_03053	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA314_03054	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_03056	COG0560	Phosphoserine phosphatase
AA314_03057	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA314_03063	COG2967	ApaG domain
AA314_03064	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA314_03068	COG2815	serine threonine protein kinase
AA314_03068	COG0515	serine threonine protein kinase
AA314_03069	COG0009	L-threonylcarbamoyladenylate synthase
AA314_03071	COG1131	(ABC) transporter
AA314_03077	COG0723	plastoquinol--plastocyanin reductase activity
AA314_03077	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_03080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AA314_03082	COG1205	dead DEAH box helicase
AA314_03082	COG1111	helicase
AA314_03083	COG3359	exonuclease
AA314_03084	COG2010	Cytochrome c
AA314_03086	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA314_03088	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA314_03093	COG3243	poly(R)-hydroxyalkanoic acid synthase
AA314_03097	COG0546	phosphoglycolate phosphatase activity
AA314_03099	COG2814	Major facilitator Superfamily
AA314_03101	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA314_03105	COG2259	Doxx family
AA314_03106	COG3590	peptidase
AA314_03107	COG1505	serine-type exopeptidase activity
AA314_03109	COG0783	Belongs to the Dps family
AA314_03110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA314_03111	COG0450	alkyl hydroperoxide reductase
AA314_03112	COG3604	Transcriptional regulator
AA314_03115	COG0739	heme binding
AA314_03115	COG1196	nuclear chromosome segregation
AA314_03115	COG0741	lytic transglycosylase activity
AA314_03121	COG5002	protein histidine kinase activity
AA314_03123	COG3854	ATPases associated with a variety of cellular activities
AA314_03128	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_03150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA314_03154	COG1187	pseudouridine synthase activity
AA314_03156	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA314_03157	COG3545	Serine hydrolase
AA314_03161	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA314_03165	COG2813	Specifically methylates the guanine in position
AA314_03180	COG0534	Mate efflux family protein
AA314_03182	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_03190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_03190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_03191	COG1619	proteins homologs of microcin C7 resistance protein MccF
AA314_03192	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_03193	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA314_03194	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_03199	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_03208	COG1100	Small GTP-binding protein
AA314_03212	COG0515	serine threonine protein kinase
AA314_03213	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA314_03214	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA314_03216	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA314_03218	COG0590	tRNA wobble adenosine to inosine editing
AA314_03219	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA314_03222	COG0463	Glycosyl transferase, family 2
AA314_03224	COG2815	serine threonine protein kinase
AA314_03224	COG0515	serine threonine protein kinase
AA314_03226	COG0204	Acyl-transferase
AA314_03233	COG5002	protein histidine kinase activity
AA314_03234	COG0156	8-amino-7-oxononanoate synthase activity
AA314_03239	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA314_03243	COG0514	ATP-dependent DNA helicase (RecQ)
AA314_03245	COG2003	Belongs to the UPF0758 family
AA314_03247	COG0745	RESPONSE REGULATOR receiver
AA314_03247	COG3706	GGDEF domain
AA314_03249	COG0745	RESPONSE REGULATOR receiver
AA314_03250	COG5002	protein histidine kinase activity
AA314_03254	COG0315	cyclic pyranopterin monophosphate synthase activity
AA314_03257	COG1819	glycosyl
AA314_03261	COG1999	signal sequence binding
AA314_03266	COG1309	transcriptional regulator
AA314_03270	COG3425	synthase
AA314_03301	COG0515	serine threonine protein kinase
AA314_03304	COG1832	CoA-binding protein
AA314_03306	COG2226	methyltransferase
AA314_03307	COG1410	methionine synthase
AA314_03307	COG0646	methionine synthase
AA314_03309	COG1657	PFAM Prenyltransferase squalene oxidase
AA314_03310	COG2124	cytochrome p450
AA314_03321	COG0438	transferase activity, transferring glycosyl groups
AA314_03322	COG0438	transferase activity, transferring glycosyl groups
AA314_03327	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_03330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AA314_03331	COG0084	hydrolase, TatD family'
AA314_03346	COG0210	DNA helicase
AA314_03347	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA314_03351	COG2137	regulation of response to DNA damage stimulus
AA314_03352	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_03356	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA314_03357	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AA314_03358	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA314_03360	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA314_03361	COG0740	serine-type endopeptidase activity
AA314_03363	COG1505	serine-type exopeptidase activity
AA314_03366	COG4166	transmembrane transport
AA314_03369	COG4565	transcriptional regulatory protein
AA314_03370	COG1678	Uncharacterized ACR, COG1678
AA314_03371	COG0271	Belongs to the BolA IbaG family
AA314_03372	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA314_03376	COG0006	proline dipeptidase activity
AA314_03398	COG0437	4 iron, 4 sulfur cluster binding
AA314_03408	COG0515	serine threonine protein kinase
AA314_03408	COG2815	serine threonine protein kinase
AA314_03415	COG3278	Belongs to the heme-copper respiratory oxidase family
AA314_03424	COG2319	Wd-40 repeat
AA314_03424	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_03433	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA314_03437	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_03443	COG2304	oxidoreductase activity
AA314_03457	COG2815	serine threonine protein kinase
AA314_03457	COG0515	serine threonine protein kinase
AA314_03458	COG0531	amino acid
AA314_03465	COG2204	response regulator
AA314_03466	COG4191	Histidine kinase
AA314_03468	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_03470	COG5002	protein histidine kinase activity
AA314_03471	COG0515	serine threonine protein kinase
AA314_03471	COG2815	serine threonine protein kinase
AA314_03472	COG0515	serine threonine protein kinase
AA314_03472	COG2815	serine threonine protein kinase
AA314_03475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA314_03477	COG1472	Belongs to the glycosyl hydrolase 3 family
AA314_03484	COG0625	glutathione transferase activity
AA314_03485	COG0583	DNA-binding transcription factor activity
AA314_03496	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA314_03499	COG0183	Belongs to the thiolase family
AA314_03500	COG1024	Enoyl-CoA hydratase
AA314_03500	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_03503	COG3394	polysaccharide catabolic process
AA314_03504	COG0463	Glycosyl transferase, family 2
AA314_03506	COG3706	GGDEF domain
AA314_03509	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA314_03510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA314_03512	COG0737	Belongs to the 5'-nucleotidase family
AA314_03514	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA314_03515	COG2223	nitrite transmembrane transporter activity
AA314_03517	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA314_03519	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_03520	COG0497	DNA recombination
AA314_03521	COG0631	protein serine/threonine phosphatase activity
AA314_03522	COG0739	heme binding
AA314_03524	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AA314_03525	COG0653	protein targeting
AA314_03526	COG0052	Belongs to the universal ribosomal protein uS2 family
AA314_03527	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA314_03528	COG0528	UMP kinase activity
AA314_03529	COG0233	cytoplasmic translational termination
AA314_03531	COG1965	Belongs to the frataxin family
AA314_03534	COG0493	'glutamate synthase
AA314_03534	COG0543	2 iron, 2 sulfur cluster binding
AA314_03537	COG0463	Glycosyl transferase, family 2
AA314_03554	COG0443	Heat shock 70 kDa protein
AA314_03555	COG0443	Heat shock 70 kDa protein
AA314_03559	COG0109	protoheme IX farnesyltransferase activity
AA314_03563	COG2205	protein histidine kinase activity
AA314_03564	COG0745	RESPONSE REGULATOR receiver
AA314_03567	COG1278	Cold shock
AA314_03578	COG0252	asparaginase activity
AA314_03579	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_03579	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_03581	COG0585	pseudouridine synthase activity
AA314_03585	COG3047	cAMP biosynthetic process
AA314_03585	COG2885	chlorophyll binding
AA314_03593	COG2084	Dehydrogenase
AA314_03600	COG0513	Belongs to the DEAD box helicase family
AA314_03611	COG0708	Exodeoxyribonuclease III
AA314_03624	COG0516	GMP reductase activity
AA314_03624	COG0517	IMP dehydrogenase activity
AA314_03625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA314_03626	COG2204	response regulator
AA314_03630	COG2885	chlorophyll binding
AA314_03636	COG2201	protein-glutamate methylesterase activity
AA314_03641	COG0254	rRNA binding
AA314_03645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_03646	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA314_03647	COG1690	Belongs to the RtcB family
AA314_03648	COG0741	lytic transglycosylase activity
AA314_03648	COG1388	LysM domain
AA314_03649	COG4191	Histidine kinase
AA314_03649	COG0784	Response regulator, receiver
AA314_03652	COG0840	transmembrane signaling receptor activity
AA314_03653	COG1657	PFAM Prenyltransferase squalene oxidase
AA314_03658	COG0513	Belongs to the DEAD box helicase family
AA314_03665	COG0513	Belongs to the DEAD box helicase family
AA314_03674	COG1024	Enoyl-CoA hydratase
AA314_03674	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_03675	COG0183	Belongs to the thiolase family
AA314_03682	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_03683	COG2204	response regulator
AA314_03684	COG0642	Histidine kinase
AA314_03696	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA314_03698	COG0300	oxidoreductase activity
AA314_03703	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_03711	COG0300	oxidoreductase activity
AA314_03712	COG0515	serine threonine protein kinase
AA314_03715	COG0515	serine threonine protein kinase
AA314_03721	COG2815	serine threonine protein kinase
AA314_03721	COG0515	serine threonine protein kinase
AA314_03724	COG2319	Wd-40 repeat
AA314_03724	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_03726	COG1994	Peptidase M50
AA314_03726	COG0517	IMP dehydrogenase activity
AA314_03727	COG2815	serine threonine protein kinase
AA314_03727	COG0515	serine threonine protein kinase
AA314_03728	COG1396	sequence-specific DNA binding
AA314_03730	COG3507	Belongs to the glycosyl hydrolase 43 family
AA314_03741	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA314_03749	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA314_03749	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_03750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_03753	COG2815	serine threonine protein kinase
AA314_03753	COG0515	serine threonine protein kinase
AA314_03756	COG4771	TonB-dependent receptor
AA314_03757	COG0542	response to heat
AA314_03763	COG0352	thiamine-phosphate diphosphorylase activity
AA314_03764	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA314_03765	COG0351	phosphomethylpyrimidine kinase
AA314_03768	COG0359	binds to the 23S rRNA
AA314_03769	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AA314_03770	COG0360	Binds together with S18 to 16S ribosomal RNA
AA314_03771	COG0193	aminoacyl-tRNA hydrolase activity
AA314_03772	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AA314_03773	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA314_03774	COG2088	sporulation resulting in formation of a cellular spore
AA314_03777	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA314_03779	COG2274	protein secretion by the type I secretion system
AA314_03782	COG4067	protein conserved in archaea
AA314_03782	COG0189	ligase activity
AA314_03790	COG0745	RESPONSE REGULATOR receiver
AA314_03792	COG0784	Response regulator, receiver
AA314_03793	COG4251	negative regulation of phosphorylation
AA314_03797	COG2226	methyltransferase
AA314_03798	COG0300	oxidoreductase activity
AA314_03800	COG1773	rubredoxin
AA314_03803	COG0612	Peptidase, M16
AA314_03804	COG4191	Histidine kinase
AA314_03810	COG1304	FMN binding
AA314_03817	COG5002	protein histidine kinase activity
AA314_03821	COG0633	Ferredoxin
AA314_03823	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA314_03824	COG0316	Belongs to the HesB IscA family
AA314_03825	COG0822	iron-sulfur transferase activity
AA314_03826	COG1104	cysteine desulfurase activity
AA314_03834	COG2030	dehydratase
AA314_03836	COG2814	Major facilitator Superfamily
AA314_03841	COG0457	Tetratricopeptide repeat
AA314_03841	COG0515	serine threonine protein kinase
AA314_03850	COG0534	Mate efflux family protein
AA314_03852	COG3220	belongs to the UPF0276 family
AA314_03858	COG3501	Rhs element vgr protein
AA314_03870	COG4650	regulator
AA314_03871	COG1690	Belongs to the RtcB family
AA314_03872	COG0430	RNA-3'-phosphate cyclase activity
AA314_03874	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_03880	COG0217	transcriptional regulatory protein
AA314_03881	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA314_03882	COG0632	four-way junction helicase activity
AA314_03900	COG1063	alcohol dehydrogenase
AA314_03901	COG2255	four-way junction helicase activity
AA314_03903	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AA314_03904	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_03904	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_03909	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA314_03911	COG0730	response to heat
AA314_03914	COG1396	sequence-specific DNA binding
AA314_03914	COG3800	Transcriptional regulator
AA314_03917	COG3220	belongs to the UPF0276 family
AA314_03924	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AA314_03928	COG2989	Protein conserved in bacteria
AA314_03933	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA314_03934	COG2890	protein-(glutamine-N5) methyltransferase activity
AA314_03938	COG1253	flavin adenine dinucleotide binding
AA314_03940	COG1196	nuclear chromosome segregation
AA314_03945	COG3829	transcription factor binding
AA314_03948	COG0459	protein refolding
AA314_03949	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA314_03953	COG1758	RNA polymerase activity
AA314_03954	COG4191	Histidine kinase
AA314_03955	COG0683	leucine binding
AA314_03956	COG0477	Major facilitator Superfamily
AA314_03961	COG1595	DNA-templated transcription, initiation
AA314_03966	COG2124	cytochrome p450
AA314_03967	COG4585	Histidine kinase
AA314_03968	COG2197	response regulator
AA314_03970	COG1335	isochorismatase
AA314_03973	COG2814	Major facilitator Superfamily
AA314_03979	COG1268	BioY protein
AA314_03980	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_03981	COG2205	protein histidine kinase activity
AA314_03981	COG0784	Response regulator, receiver
AA314_03982	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_03990	COG0583	DNA-binding transcription factor activity
AA314_03994	COG0412	Dienelactone hydrolase
AA314_04023	COG0842	Transport permease protein
AA314_04023	COG1129	ABC transporter
AA314_04043	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AA314_04045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_04046	COG0737	Belongs to the 5'-nucleotidase family
AA314_04048	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_04049	COG1132	(ABC) transporter
AA314_04052	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_04073	COG1136	(ABC) transporter
AA314_04074	COG0577	efflux transmembrane transporter activity
AA314_04074	COG1136	(ABC) transporter
AA314_04076	COG2234	aminopeptidase activity
AA314_04080	COG1253	flavin adenine dinucleotide binding
AA314_04081	COG0784	Response regulator, receiver
AA314_04081	COG2205	protein histidine kinase activity
AA314_04081	COG5002	protein histidine kinase activity
AA314_04082	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA314_04085	COG0704	Plays a role in the regulation of phosphate uptake
AA314_04086	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA314_04087	COG0581	inorganic phosphate transmembrane transporter activity
AA314_04088	COG0573	inorganic phosphate transmembrane transporter activity
AA314_04089	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA314_04091	COG2062	phosphohistidine phosphatase, SixA
AA314_04093	COG5002	protein histidine kinase activity
AA314_04094	COG0745	RESPONSE REGULATOR receiver
AA314_04097	COG1399	metal-binding, possibly nucleic acid-binding protein
AA314_04100	COG0642	Histidine kinase
AA314_04108	COG3158	transport of potassium into the cell
AA314_04109	COG2066	Belongs to the glutaminase family
AA314_04111	COG0667	Aldo Keto reductase
AA314_04112	COG1595	DNA-templated transcription, initiation
AA314_04113	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA314_04115	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA314_04121	COG1196	nuclear chromosome segregation
AA314_04121	COG0741	lytic transglycosylase activity
AA314_04121	COG0739	heme binding
AA314_04126	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA314_04129	COG0583	DNA-binding transcription factor activity
AA314_04130	COG0582	viral genome integration into host DNA
AA314_04135	COG0028	Belongs to the TPP enzyme family
AA314_04137	COG0668	transmembrane transport
AA314_04138	COG3387	PFAM Glycoside hydrolase 15-related
AA314_04140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA314_04141	COG0416	fatty acid biosynthetic process
AA314_04142	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_04144	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_04145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA314_04146	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA314_04147	COG0698	ribose 5-phosphate isomerase
AA314_04148	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA314_04149	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA314_04150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA314_04150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA314_04151	COG1657	PFAM Prenyltransferase squalene oxidase
AA314_04160	COG2124	cytochrome p450
AA314_04162	COG2124	cytochrome p450
AA314_04164	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA314_04164	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA314_04165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA314_04166	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_04169	COG2198	Histidine kinase
AA314_04169	COG0643	Histidine kinase
AA314_04170	COG0835	chemotaxis
AA314_04173	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_04174	COG2201	protein-glutamate methylesterase activity
AA314_04176	COG5280	Phage tail tape measure protein TP901
AA314_04176	COG3953	SLT domain
AA314_04179	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA314_04187	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA314_04188	COG0745	RESPONSE REGULATOR receiver
AA314_04189	COG0495	leucyl-tRNA aminoacylation
AA314_04193	COG3956	TIGRFAM MazG family protein
AA314_04195	COG0457	Tetratricopeptide repeat
AA314_04197	COG1480	7TM receptor with intracellular HD hydrolase
AA314_04198	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA314_04198	COG0662	Cupin 2, conserved barrel domain protein
AA314_04205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AA314_04206	COG4591	ABC-type transport system involved in lipoprotein release permease component
AA314_04207	COG1136	(ABC) transporter
AA314_04208	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_04210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA314_04211	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA314_04212	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA314_04216	COG2095	MarC family integral membrane protein
AA314_04218	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA314_04222	COG1247	-acetyltransferase
AA314_04224	COG2985	domain, Protein
AA314_04224	COG0569	domain protein
AA314_04227	COG1132	(ABC) transporter
AA314_04229	COG3227	Zinc metalloprotease (Elastase)
AA314_04230	COG1519	Transferase
AA314_04232	COG1663	tetraacyldisaccharide 4'-kinase activity
AA314_04233	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA314_04233	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA314_04234	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA314_04234	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA314_04236	COG1561	YicC-like family, N-terminal region
AA314_04237	COG0194	GDP metabolic process
AA314_04238	COG0515	serine threonine protein kinase
AA314_04240	COG1509	lysine 2,3-aminomutase activity
AA314_04243	COG2247	cell wall binding repeat
AA314_04243	COG2385	sporulation resulting in formation of a cellular spore
AA314_04248	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA314_04249	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA314_04251	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA314_04251	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AA314_04258	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA314_04259	COG1597	lipid kinase activity
AA314_04261	COG2204	response regulator
AA314_04262	COG2205	protein histidine kinase activity
AA314_04263	COG0659	secondary active sulfate transmembrane transporter activity
AA314_04265	COG0402	S-adenosylhomocysteine deaminase activity
AA314_04266	COG0515	serine threonine protein kinase
AA314_04275	COG1193	negative regulation of DNA recombination
AA314_04277	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_04279	COG0714	Associated with various cellular activities
AA314_04281	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA314_04284	COG2030	dehydratase
AA314_04286	COG1960	acyl-CoA dehydrogenase activity
AA314_04287	COG1605	Chorismate mutase
AA314_04287	COG0077	Prephenate dehydratase
AA314_04292	COG0811	peptide transport
AA314_04296	COG0444	Belongs to the ABC transporter superfamily
AA314_04297	COG4608	Belongs to the ABC transporter superfamily
AA314_04313	COG1716	ATPase activity
AA314_04317	COG0745	RESPONSE REGULATOR receiver
AA314_04318	COG0142	geranyltranstransferase activity
AA314_04319	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA314_04320	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AA314_04324	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_04325	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_04336	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA314_04340	COG0741	lytic transglycosylase activity
AA314_04356	COG1295	ribonuclease BN
AA314_04357	COG0488	(ABC) transporter
AA314_04363	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_04365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA314_04366	COG0343	queuine tRNA-ribosyltransferase activity
AA314_04373	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AA314_04374	COG2814	Major facilitator Superfamily
AA314_04378	COG0022	dehydrogenase e1 component
AA314_04380	COG0038	chloride channel
AA314_04381	COG5002	protein histidine kinase activity
AA314_04382	COG2208	phosphoserine phosphatase activity
AA314_04385	COG4771	TonB-dependent receptor
AA314_04387	COG0515	serine threonine protein kinase
AA314_04391	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_04391	COG2022	thiamine diphosphate biosynthetic process
AA314_04396	COG2124	cytochrome p450
AA314_04398	COG4245	von Willebrand factor, type A
AA314_04399	COG0631	protein serine/threonine phosphatase activity
AA314_04400	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
AA314_04409	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_04410	COG1169	isochorismate synthase
AA314_04411	COG1021	2,3-dihydroxybenzoate-AMP ligase
AA314_04412	COG1535	isochorismatase
AA314_04412	COG3433	isochorismatase activity
AA314_04413	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA314_04415	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AA314_04424	COG3596	GTP binding
AA314_04430	COG3209	COG3209 Rhs family protein
AA314_04430	COG4104	PAAR repeat-containing protein
AA314_04430	COG3209	COG3209 Rhs family protein
AA314_04430	COG4104	PAAR repeat-containing protein
AA314_04440	COG2204	response regulator
AA314_04441	COG0459	protein refolding
AA314_04444	COG3706	GGDEF domain
AA314_04447	COG0525	valine-tRNA ligase activity
AA314_04450	COG0824	Thioesterase
AA314_04451	COG1494	fructose-1,6-bisphosphatase
AA314_04455	COG0148	phosphopyruvate hydratase activity
AA314_04456	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA314_04464	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA314_04466	COG5002	protein histidine kinase activity
AA314_04477	COG1215	transferase activity, transferring glycosyl groups
AA314_04479	COG0515	serine threonine protein kinase
AA314_04482	COG0010	Belongs to the arginase family
AA314_04484	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AA314_04486	COG1984	allophanate hydrolase subunit 2
AA314_04487	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AA314_04488	COG4336	lyase activity
AA314_04490	COG0583	DNA-binding transcription factor activity
AA314_04493	COG0515	serine threonine protein kinase
AA314_04493	COG2815	serine threonine protein kinase
AA314_04494	COG1643	Atp-dependent helicase
AA314_04497	COG2124	cytochrome p450
AA314_04501	COG4464	protein tyrosine phosphatase activity
AA314_04505	COG5002	protein histidine kinase activity
AA314_04531	COG2204	response regulator
AA314_04534	COG0529	Catalyzes the synthesis of activated sulfate
AA314_04539	COG0631	protein serine/threonine phosphatase activity
AA314_04542	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AA314_04543	COG1573	uracil-dna glycosylase
AA314_04545	COG0604	alcohol dehydrogenase
AA314_04546	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA314_04548	COG5012	cobalamin binding
AA314_04549	COG1607	acyl-coa hydrolase
AA314_04550	COG3246	L-lysine catabolic process to acetate
AA314_04552	COG0183	Belongs to the thiolase family
AA314_04553	COG1309	transcriptional regulator
AA314_04554	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA314_04559	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_04565	COG0697	spore germination
AA314_04566	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_04570	COG1819	glycosyl
AA314_04577	COG4191	Histidine kinase
AA314_04577	COG0784	Response regulator, receiver
AA314_04578	COG4251	negative regulation of phosphorylation
AA314_04581	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AA314_04583	COG5002	protein histidine kinase activity
AA314_04602	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA314_04615	COG0037	tRNA processing
AA314_04617	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_04618	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AA314_04619	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA314_04620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AA314_04621	COG0736	holo-[acyl-carrier-protein] synthase activity
AA314_04622	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA314_04622	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA314_04623	COG0802	atpase or kinase
AA314_04627	COG0745	RESPONSE REGULATOR receiver
AA314_04628	COG2205	protein histidine kinase activity
AA314_04628	COG2202	Pas domain
AA314_04630	COG1228	amidohydrolase
AA314_04631	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AA314_04632	COG0137	argininosuccinate synthase activity
AA314_04636	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA314_04644	COG1138	Cytochrome C-type biogenesis protein
AA314_04645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AA314_04647	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA314_04649	COG4133	protoheme IX ABC transporter activity
AA314_04654	COG0438	transferase activity, transferring glycosyl groups
AA314_04668	COG0352	thiamine-phosphate diphosphorylase activity
AA314_04669	COG2022	thiamine diphosphate biosynthetic process
AA314_04676	COG5002	protein histidine kinase activity
AA314_04683	COG0328	RNA-DNA hybrid ribonuclease activity
AA314_04687	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA314_04689	COG0745	RESPONSE REGULATOR receiver
AA314_04691	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA314_04692	COG0598	Magnesium transport protein CorA
AA314_04715	COG2937	Belongs to the GPAT DAPAT family
AA314_04716	COG0018	arginyl-trna synthetase
AA314_04718	COG2205	protein histidine kinase activity
AA314_04718	COG2202	Pas domain
AA314_04724	COG0049	tRNA binding
AA314_04725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA314_04726	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA314_04728	COG0051	transcription antitermination factor activity, RNA binding
AA314_04729	COG0088	Forms part of the polypeptide exit tunnel
AA314_04730	COG0089	rRNA binding
AA314_04731	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA314_04732	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA314_04733	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AA314_04734	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA314_04735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA314_04736	COG0255	Belongs to the universal ribosomal protein uL29 family
AA314_04737	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AA314_04738	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA314_04739	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA314_04741	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA314_04742	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA314_04743	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA314_04744	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AA314_04745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AA314_04746	COG1841	ribosomal large subunit assembly
AA314_04747	COG0200	Binds to the 23S rRNA
AA314_04750	COG0563	adenylate kinase activity
AA314_04752	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA314_04753	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AA314_04754	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA314_04755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA314_04756	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA314_04757	COG0202	RNA polymerase activity
AA314_04758	COG0203	ribosomal protein L17
AA314_04767	COG2313	pseudouridylate synthase activity
AA314_04775	COG0741	lytic transglycosylase activity
AA314_04781	COG3706	GGDEF domain
AA314_04784	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AA314_04791	COG3781	membrane
AA314_04794	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA314_04795	COG4266	Belongs to the allantoicase family
AA314_04796	COG2351	hydroxyisourate hydrolase activity
AA314_04797	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AA314_04799	COG0829	nickel cation binding
AA314_04800	COG0832	Belongs to the urease beta subunit family
AA314_04800	COG0831	urea catabolic process
AA314_04801	COG0804	urea catabolic process
AA314_04803	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA314_04804	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA314_04805	COG3250	beta-galactosidase activity
AA314_04809	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA314_04811	COG2205	protein histidine kinase activity
AA314_04811	COG0784	Response regulator, receiver
AA314_04820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA314_04822	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA314_04826	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA314_04827	COG1058	Belongs to the CinA family
AA314_04827	COG1546	Belongs to the CinA family
AA314_04828	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_04830	COG0531	amino acid
AA314_04831	COG0017	Asparaginyl-tRNA synthetase
AA314_04834	COG1999	signal sequence binding
AA314_04835	COG2205	protein histidine kinase activity
AA314_04853	COG3706	GGDEF domain
AA314_04853	COG0745	RESPONSE REGULATOR receiver
AA314_04865	COG1100	Small GTP-binding protein
AA314_04867	COG5464	transposase or invertase
AA314_04869	COG2133	pyrroloquinoline quinone binding
AA314_04872	COG0641	radical SAM
AA314_04886	COG2815	serine threonine protein kinase
AA314_04886	COG0515	serine threonine protein kinase
AA314_04888	COG5464	transposase or invertase
AA314_04901	COG0217	transcriptional regulatory protein
AA314_04904	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA314_04908	COG0577	efflux transmembrane transporter activity
AA314_04908	COG1136	(ABC) transporter
AA314_04914	COG3179	chitinase
AA314_04921	COG1819	glycosyl
AA314_04924	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_04929	COG3852	Histidine kinase
AA314_04934	COG2986	histidine ammonia-lyase
AA314_04935	COG0527	aspartate kinase activity
AA314_04944	COG1902	pentaerythritol trinitrate reductase activity
AA314_04948	COG0210	DNA helicase
AA314_04949	COG0443	Heat shock 70 kDa protein
AA314_04953	COG0501	Belongs to the peptidase M48B family
AA314_04955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_04955	COG2146	nitrite reductase [NAD(P)H] activity
AA314_04959	COG1215	transferase activity, transferring glycosyl groups
AA314_04962	COG3420	alginic acid biosynthetic process
AA314_04963	COG1215	transferase activity, transferring glycosyl groups
AA314_04970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA314_04975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AA314_04979	COG1132	(ABC) transporter
AA314_04981	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_04983	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_04985	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_04990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA314_04990	COG0512	Glutamine amidotransferase of anthranilate synthase
AA314_04994	COG1834	amidinotransferase
AA314_04995	COG0025	NhaP-type Na H and K H
AA314_04996	COG0617	tRNA 3'-terminal CCA addition
AA314_04997	COG0482	sulfurtransferase activity
AA314_04999	COG1482	cell wall glycoprotein biosynthetic process
AA314_05004	COG0481	GTPase activity
AA314_05007	COG0540	Belongs to the ATCase OTCase family
AA314_05009	COG0505	Belongs to the CarA family
AA314_05014	COG1022	Amp-dependent synthetase and ligase
AA314_05015	COG0372	Belongs to the citrate synthase family
AA314_05018	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA314_05019	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AA314_05021	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA314_05021	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA314_05022	COG2226	methyltransferase
AA314_05023	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AA314_05023	COG1605	Chorismate mutase
AA314_05024	COG1169	isochorismate synthase
AA314_05026	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AA314_05028	COG1575	Belongs to the MenA family. Type 1 subfamily
AA314_05029	COG4948	Mandelate Racemase Muconate Lactonizing
AA314_05033	COG0515	serine threonine protein kinase
AA314_05037	COG2378	regulation of single-species biofilm formation
AA314_05039	COG4106	trans-aconitate 2-methyltransferase activity
AA314_05040	COG0538	isocitrate dehydrogenase activity
AA314_05042	COG1053	succinate dehydrogenase
AA314_05043	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA314_05044	COG0045	succinate-CoA ligase (ADP-forming) activity
AA314_05045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AA314_05047	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA314_05048	COG0228	four-way junction DNA binding
AA314_05049	COG1837	Belongs to the UPF0109 family
AA314_05050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA314_05051	COG0336	Belongs to the RNA methyltransferase TrmD family
AA314_05052	COG0335	large ribosomal subunit rRNA binding
AA314_05054	COG0792	nuclease activity
AA314_05055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AA314_05058	COG2204	response regulator
AA314_05061	COG0728	peptidoglycan biosynthetic process
AA314_05062	COG0539	negative regulation of cytoplasmic translation
AA314_05070	COG2255	four-way junction helicase activity
AA314_05074	COG4191	Histidine kinase
AA314_05079	COG0457	Tetratricopeptide repeat
AA314_05081	COG2204	response regulator
AA314_05085	COG0515	serine threonine protein kinase
AA314_05100	COG2085	NADP oxidoreductase coenzyme F420-dependent
AA314_05101	COG2366	antibiotic biosynthetic process
AA314_05114	COG0753	catalase activity
AA314_05114	COG0693	protein deglycase activity
AA314_05117	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA314_05119	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_05120	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_05125	COG2304	oxidoreductase activity
AA314_05131	COG1278	Cold shock
AA314_05134	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_05138	COG0545	Peptidyl-prolyl cis-trans isomerase
AA314_05143	COG0628	permease
AA314_05145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA314_05147	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AA314_05148	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA314_05149	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA314_05150	COG0072	phenylalanine-tRNA ligase activity
AA314_05153	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_05154	COG2274	protein secretion by the type I secretion system
AA314_05158	COG0840	transmembrane signaling receptor activity
AA314_05160	COG2226	methyltransferase
AA314_05161	COG4104	PAAR repeat-containing protein
AA314_05164	COG1946	Acyl-CoA thioesterase
AA314_05167	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA314_05168	COG1116	anion transmembrane transporter activity
AA314_05175	COG1131	(ABC) transporter
AA314_05182	COG0525	valine-tRNA ligase activity
AA314_05192	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA314_05206	COG0386	Belongs to the glutathione peroxidase family
AA314_05209	COG0726	polysaccharide deacetylase
AA314_05225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_05231	COG0702	epimerase
AA314_05240	COG5002	protein histidine kinase activity
AA314_05241	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_05241	COG4221	oxidoreductase activity
AA314_05241	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA314_05241	COG3321	synthase
AA314_05243	COG1047	Peptidyl-prolyl cis-trans
AA314_05256	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA314_05257	COG3281	Trehalose synthase
AA314_05259	COG0366	Alpha amylase catalytic
AA314_05271	COG5002	protein histidine kinase activity
AA314_05274	COG3706	GGDEF domain
AA314_05275	COG2521	methyltransferase
AA314_05275	COG2136	Putative SAM-dependent methyltransferase
AA314_05276	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA314_05290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_05298	COG5002	protein histidine kinase activity
AA314_05298	COG3447	MASE1 domain protein
AA314_05298	COG5001	Diguanylate cyclase
AA314_05301	COG5002	protein histidine kinase activity
AA314_05303	COG2124	cytochrome p450
AA314_05311	COG0612	Peptidase, M16
AA314_05313	COG0564	pseudouridine synthase activity
AA314_05317	COG2080	2 iron, 2 sulfur cluster binding
AA314_05320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_05322	COG0583	DNA-binding transcription factor activity
AA314_05323	COG0697	spore germination
AA314_05329	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA314_05332	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AA314_05337	COG0688	phosphatidylethanolamine metabolic process
AA314_05338	COG0124	histidyl-tRNA synthetase
AA314_05347	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA314_05351	COG2198	Histidine kinase
AA314_05351	COG2205	protein histidine kinase activity
AA314_05351	COG0784	Response regulator, receiver
AA314_05352	COG0745	RESPONSE REGULATOR receiver
AA314_05352	COG3706	GGDEF domain
AA314_05355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_05355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_05357	COG0142	geranyltranstransferase activity
AA314_05358	COG1830	Aldolase
AA314_05363	COG1033	growth of symbiont in host cell
AA314_05363	COG2409	Drug exporters of the RND superfamily
AA314_05367	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA314_05368	COG1703	isobutyryl-CoA mutase activity
AA314_05368	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA314_05368	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA314_05369	COG1705	Flagellar rod assembly protein muramidase FlgJ
AA314_05369	COG1388	LysM domain
AA314_05376	COG2319	Wd-40 repeat
AA314_05376	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_05381	COG1024	Enoyl-CoA hydratase
AA314_05382	COG4251	negative regulation of phosphorylation
AA314_05383	COG0784	Response regulator, receiver
AA314_05390	COG1131	(ABC) transporter
AA314_05393	COG2205	protein histidine kinase activity
AA314_05394	COG3590	peptidase
AA314_05399	COG1012	belongs to the aldehyde dehydrogenase family
AA314_05401	COG5006	permease, DMT superfamily
AA314_05415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_05418	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_05418	COG2319	Wd-40 repeat
AA314_05423	COG0596	Alpha beta hydrolase
AA314_05425	COG1733	regulation of RNA biosynthetic process
AA314_05427	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_05432	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_05446	COG3848	Pyruvate phosphate dikinase
AA314_05446	COG0574	Belongs to the PEP-utilizing enzyme family
AA314_05449	COG0596	Alpha beta hydrolase
AA314_05452	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA314_05462	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA314_05463	COG1960	acyl-CoA dehydrogenase activity
AA314_05464	COG0571	ribonuclease III activity
AA314_05466	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA314_05467	COG1160	GTP binding
AA314_05470	COG0494	nUDIX hydrolase
AA314_05475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA314_05475	COG0519	Catalyzes the synthesis of GMP from XMP
AA314_05477	COG0516	GMP reductase activity
AA314_05477	COG0517	IMP dehydrogenase activity
AA314_05478	COG0443	Heat shock 70 kDa protein
AA314_05479	COG0586	Pfam SNARE associated Golgi protein
AA314_05481	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA314_05482	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA314_05485	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_05488	COG0720	synthase
AA314_05489	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA314_05490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AA314_05491	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AA314_05492	COG0183	Belongs to the thiolase family
AA314_05494	COG1960	acyl-CoA dehydrogenase activity
AA314_05496	COG1960	acyl-CoA dehydrogenase activity
AA314_05497	COG1024	Enoyl-CoA hydratase
AA314_05498	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_05501	COG0489	protein tyrosine kinase activity
AA314_05514	COG0776	regulation of translation
AA314_05520	COG0583	DNA-binding transcription factor activity
AA314_05521	COG3321	synthase
AA314_05521	COG0604	alcohol dehydrogenase
AA314_05521	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_05523	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA314_05524	COG1643	Atp-dependent helicase
AA314_05525	COG1643	Atp-dependent helicase
AA314_05526	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AA314_05529	COG5002	protein histidine kinase activity
AA314_05534	COG2124	cytochrome p450
AA314_05536	COG4566	intracellular signal transduction
AA314_05541	COG0412	Dienelactone hydrolase
AA314_05547	COG1131	(ABC) transporter
AA314_05550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_05554	COG3227	Zinc metalloprotease (Elastase)
AA314_05555	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AA314_05559	COG0534	Mate efflux family protein
AA314_05563	COG0004	ammonium transporteR
AA314_05565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA314_05568	COG2378	regulation of single-species biofilm formation
AA314_05572	COG0745	RESPONSE REGULATOR receiver
AA314_05575	COG4191	Histidine kinase
AA314_05582	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA314_05588	COG1309	transcriptional regulator
AA314_05592	COG2124	cytochrome p450
AA314_05600	COG5002	protein histidine kinase activity
AA314_05603	COG2205	protein histidine kinase activity
AA314_05604	COG0745	RESPONSE REGULATOR receiver
AA314_05608	COG0531	amino acid
AA314_05610	COG0477	Major facilitator Superfamily
AA314_05625	COG0542	response to heat
AA314_05626	COG0542	response to heat
AA314_05638	COG0430	RNA-3'-phosphate cyclase activity
AA314_05641	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_05643	COG1187	pseudouridine synthase activity
AA314_05644	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AA314_05645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AA314_05646	COG0180	Tryptophanyl-tRNA synthetase
AA314_05650	COG4974	Belongs to the 'phage' integrase family
AA314_05655	COG2815	serine threonine protein kinase
AA314_05655	COG0515	serine threonine protein kinase
AA314_05659	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA314_05660	COG0009	L-threonylcarbamoyladenylate synthase
AA314_05661	COG0475	glutathione-regulated potassium exporter activity
AA314_05661	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA314_05666	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AA314_05675	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA314_05678	COG0784	Response regulator, receiver
AA314_05678	COG2198	Histidine kinase
AA314_05678	COG5002	protein histidine kinase activity
AA314_05679	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA314_05681	COG3291	Pkd domain containing protein
AA314_05681	COG4447	cellulose binding
AA314_05681	COG5520	Belongs to the glycosyl hydrolase 30 family
AA314_05682	COG3831	ATPase activity
AA314_05684	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_05684	COG2205	protein histidine kinase activity
AA314_05685	COG0714	Associated with various cellular activities
AA314_05686	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AA314_05687	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AA314_05690	COG1695	Transcriptional regulator
AA314_05691	COG5002	protein histidine kinase activity
AA314_05693	COG0006	proline dipeptidase activity
AA314_05697	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA314_05701	COG2706	6-phosphogluconolactonase activity
AA314_05702	COG2205	protein histidine kinase activity
AA314_05702	COG0784	Response regulator, receiver
AA314_05736	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA314_05737	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_05741	COG0515	serine threonine protein kinase
AA314_05742	COG3227	Zinc metalloprotease (Elastase)
AA314_05743	COG3227	Zinc metalloprotease (Elastase)
AA314_05750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA314_05753	COG1595	DNA-templated transcription, initiation
AA314_05760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA314_05763	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AA314_05769	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA314_05773	COG5002	protein histidine kinase activity
AA314_05776	COG2815	serine threonine protein kinase
AA314_05776	COG0515	serine threonine protein kinase
AA314_05779	COG0585	pseudouridine synthase activity
AA314_05780	COG1595	DNA-templated transcription, initiation
AA314_05786	COG0300	oxidoreductase activity
AA314_05794	COG3239	Fatty acid desaturase
AA314_05795	COG0204	Acyl-transferase
AA314_05795	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_05797	COG0708	Exodeoxyribonuclease III
AA314_05798	COG0515	serine threonine protein kinase
AA314_05800	COG0667	Aldo Keto reductase
AA314_05807	COG0596	Alpha beta hydrolase
AA314_05808	COG0667	Aldo Keto reductase
AA314_05816	COG1960	acyl-CoA dehydrogenase activity
AA314_05817	COG1073	alpha beta
AA314_05842	COG0463	Glycosyl transferase, family 2
AA314_05859	COG2234	aminopeptidase activity
AA314_05860	COG0667	Aldo Keto reductase
AA314_05862	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_05866	COG2894	cell division
AA314_05868	COG2815	serine threonine protein kinase
AA314_05868	COG0515	serine threonine protein kinase
AA314_05870	COG2204	response regulator
AA314_05874	COG0628	permease
AA314_05876	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA314_05877	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA314_05878	COG1438	arginine binding
AA314_05879	COG0165	Argininosuccinate lyase
AA314_05880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA314_05884	COG2027	D-alanyl-D-alanine carboxypeptidase
AA314_05885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA314_05890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA314_05891	COG0742	ribosomal rna small subunit methyltransferase
AA314_05901	COG0217	transcriptional regulatory protein
AA314_05906	COG1858	cytochrome C peroxidase
AA314_05907	COG2207	Transcriptional regulator
AA314_05913	COG0477	Major facilitator Superfamily
AA314_05916	COG1741	Belongs to the pirin family
AA314_05917	COG0506	proline dehydrogenase activity
AA314_05929	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AA314_05936	COG0739	heme binding
AA314_05936	COG0741	lytic transglycosylase activity
AA314_05936	COG1196	nuclear chromosome segregation
AA314_05940	COG0714	Associated with various cellular activities
AA314_05943	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA314_05944	COG1297	OPT oligopeptide transporter protein
AA314_05952	COG0493	'glutamate synthase
AA314_05952	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA314_05954	COG0564	pseudouridine synthase activity
AA314_05957	COG0455	bacterial-type flagellum organization
AA314_05960	COG1921	L-seryl-tRNASec selenium transferase activity
AA314_05961	COG0741	lytic transglycosylase activity
AA314_05962	COG4191	Histidine kinase
AA314_05965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA314_05968	COG0515	serine threonine protein kinase
AA314_05968	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_05972	COG0488	(ABC) transporter
AA314_05976	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA314_05977	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA314_05978	COG0825	malonyl-CoA metabolic process
AA314_05987	COG2766	serine protein kinase
AA314_05990	COG0443	Heat shock 70 kDa protein
AA314_05995	COG0101	tRNA pseudouridine synthase activity
AA314_05997	COG1606	tRNA processing
AA314_06001	COG0425	Belongs to the sulfur carrier protein TusA family
AA314_06002	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA314_06004	COG4585	Histidine kinase
AA314_06013	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AA314_06016	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_06019	COG0113	porphobilinogen synthase activity
AA314_06024	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AA314_06034	COG0745	RESPONSE REGULATOR receiver
AA314_06037	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA314_06038	COG0686	Belongs to the AlaDH PNT family
AA314_06039	COG1595	DNA-templated transcription, initiation
AA314_06047	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AA314_06048	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AA314_06048	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AA314_06049	COG0460	homoserine dehydrogenase
AA314_06055	COG2070	2-Nitropropane dioxygenase
AA314_06057	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_06059	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA314_06060	COG0572	uridine kinase
AA314_06062	COG3220	belongs to the UPF0276 family
AA314_06066	COG1595	DNA-templated transcription, initiation
AA314_06067	COG2391	methyltransferase activity
AA314_06071	COG0427	acetyl-CoA hydrolase
AA314_06072	COG5002	protein histidine kinase activity
AA314_06072	COG3447	MASE1 domain protein
AA314_06072	COG5001	Diguanylate cyclase
AA314_06074	COG1063	alcohol dehydrogenase
AA314_06085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_06086	COG1803	Methylglyoxal synthase
AA314_06105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_06106	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_06113	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA314_06122	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA314_06122	COG0475	glutathione-regulated potassium exporter activity
AA314_06123	COG0583	DNA-binding transcription factor activity
AA314_06129	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA314_06132	COG2124	cytochrome p450
AA314_06133	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_06137	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_06138	COG1136	(ABC) transporter
AA314_06138	COG0577	efflux transmembrane transporter activity
AA314_06139	COG1136	(ABC) transporter
AA314_06139	COG0577	efflux transmembrane transporter activity
AA314_06140	COG1136	(ABC) transporter
AA314_06140	COG0577	efflux transmembrane transporter activity
AA314_06144	COG0542	response to heat
AA314_06162	COG0737	Belongs to the 5'-nucleotidase family
AA314_06167	COG0515	serine threonine protein kinase
AA314_06167	COG0457	Tetratricopeptide repeat
AA314_06173	COG2205	protein histidine kinase activity
AA314_06174	COG0745	RESPONSE REGULATOR receiver
AA314_06186	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA314_06188	COG3876	Protein conserved in bacteria
AA314_06191	COG1193	negative regulation of DNA recombination
AA314_06193	COG0515	serine threonine protein kinase
AA314_06196	COG0557	exoribonuclease II activity
AA314_06198	COG0303	'Molybdopterin
AA314_06199	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA314_06199	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA314_06204	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA314_06206	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA314_06210	COG0557	exoribonuclease II activity
AA314_06211	COG0739	heme binding
AA314_06219	COG0107	imidazoleglycerol-phosphate synthase activity
AA314_06220	COG0131	Imidazoleglycerol-phosphate dehydratase
AA314_06221	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA314_06222	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA314_06224	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AA314_06225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA314_06226	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_06226	COG2022	thiamine diphosphate biosynthetic process
AA314_06228	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA314_06230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA314_06232	COG0517	IMP dehydrogenase activity
AA314_06232	COG0516	GMP reductase activity
AA314_06236	COG2204	response regulator
AA314_06237	COG4191	Histidine kinase
AA314_06238	COG0745	RESPONSE REGULATOR receiver
AA314_06238	COG4566	intracellular signal transduction
AA314_06239	COG2205	protein histidine kinase activity
AA314_06243	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AA314_06252	COG1335	isochorismatase
AA314_06262	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA314_06271	COG2815	serine threonine protein kinase
AA314_06271	COG0515	serine threonine protein kinase
AA314_06283	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AA314_06284	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_06285	COG0489	protein tyrosine kinase activity
AA314_06291	COG0791	NLP P60 protein
AA314_06298	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA314_06311	COG1278	Cold shock
AA314_06320	COG1595	DNA-templated transcription, initiation
AA314_06325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA314_06328	COG2204	response regulator
AA314_06329	COG3706	GGDEF domain
AA314_06333	COG0564	pseudouridine synthase activity
AA314_06338	COG1131	(ABC) transporter
AA314_06339	COG0425	Belongs to the sulfur carrier protein TusA family
AA314_06340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_06340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_06348	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AA314_06351	COG1454	alcohol dehydrogenase
AA314_06356	COG0443	Heat shock 70 kDa protein
AA314_06360	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AA314_06361	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA314_06364	COG0535	radical SAM domain protein
AA314_06374	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_06375	COG3304	Inner membrane component domain
AA314_06378	COG4104	PAAR repeat-containing protein
AA314_06381	COG0577	efflux transmembrane transporter activity
AA314_06381	COG1136	(ABC) transporter
AA314_06383	COG0436	Aminotransferase
AA314_06386	COG4191	Histidine kinase
AA314_06387	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_06387	COG1672	PFAM Archaeal ATPase
AA314_06410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA314_06410	COG2755	lipolytic protein G-D-S-L family
AA314_06411	COG2354	Protein conserved in bacteria
AA314_06412	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_06418	COG0583	DNA-binding transcription factor activity
AA314_06419	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_06427	COG0596	Alpha beta hydrolase
AA314_06437	COG5002	protein histidine kinase activity
AA314_06441	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA314_06443	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA314_06444	COG3940	Belongs to the glycosyl hydrolase 43 family
AA314_06453	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA314_06454	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA314_06456	COG0175	sulfate reduction
AA314_06457	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA314_06457	COG1648	precorrin-2 dehydrogenase activity
AA314_06458	COG1648	precorrin-2 dehydrogenase activity
AA314_06458	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA314_06460	COG0175	sulfate reduction
AA314_06462	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_06462	COG1672	PFAM Archaeal ATPase
AA314_06463	COG1295	ribonuclease BN
AA314_06463	COG1959	2 iron, 2 sulfur cluster binding
AA314_06466	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_06469	COG2133	pyrroloquinoline quinone binding
AA314_06470	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_06473	COG0745	RESPONSE REGULATOR receiver
AA314_06479	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_06484	COG1999	signal sequence binding
AA314_06494	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA314_06502	COG2897	thiosulfate sulfurtransferase activity
AA314_06504	COG2226	methyltransferase
AA314_06510	COG0071	Belongs to the small heat shock protein (HSP20) family
AA314_06522	COG0484	heat shock protein binding
AA314_06523	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AA314_06525	COG1872	DUF167
AA314_06533	COG1450	Type ii and iii secretion system protein
AA314_06538	COG0751	glycine-tRNA ligase activity
AA314_06539	COG0752	glycyl-tRNA synthetase alpha subunit
AA314_06542	COG1381	Involved in DNA repair and RecF pathway recombination
AA314_06549	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA314_06550	COG0085	RNA polymerase activity
AA314_06551	COG0222	ribosome binding
AA314_06552	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA314_06553	COG0081	regulation of translation
AA314_06554	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AA314_06557	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA314_06558	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA314_06559	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA314_06567	COG1643	Atp-dependent helicase
AA314_06573	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA314_06575	COG1960	acyl-CoA dehydrogenase activity
AA314_06580	COG1064	alcohol dehydrogenase
AA314_06583	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA314_06583	COG0047	phosphoribosylformylglycinamidine synthase activity
AA314_06585	COG3383	formate dehydrogenase (NAD+) activity
AA314_06587	COG2226	methyltransferase
AA314_06597	COG2385	sporulation resulting in formation of a cellular spore
AA314_06602	COG2205	protein histidine kinase activity
AA314_06604	COG2080	2 iron, 2 sulfur cluster binding
AA314_06605	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AA314_06606	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA314_06614	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA314_06614	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA314_06616	COG0509	glycine decarboxylation via glycine cleavage system
AA314_06618	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AA314_06620	COG0596	Alpha beta hydrolase
AA314_06622	COG4771	TonB-dependent receptor
AA314_06624	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA314_06625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA314_06626	COG5002	protein histidine kinase activity
AA314_06628	COG0626	cystathionine gamma-synthase activity
AA314_06629	COG0626	cystathionine gamma-synthase activity
AA314_06631	COG0460	homoserine dehydrogenase
AA314_06631	COG0527	aspartate kinase activity
AA314_06637	COG2840	Smr protein MutS2
AA314_06639	COG0167	dihydroorotate dehydrogenase activity
AA314_06640	COG2124	cytochrome p450
AA314_06641	COG4977	sequence-specific DNA binding
AA314_06647	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AA314_06650	COG0237	dephospho-CoA kinase activity
AA314_06655	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AA314_06657	COG5464	transposase or invertase
AA314_06660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AA314_06665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA314_06670	COG3706	GGDEF domain
AA314_06672	COG1543	Belongs to the glycosyl hydrolase 57 family
AA314_06674	COG0438	transferase activity, transferring glycosyl groups
AA314_06675	COG1196	nuclear chromosome segregation
AA314_06675	COG0745	RESPONSE REGULATOR receiver
AA314_06678	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AA314_06680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA314_06682	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AA314_06683	COG1227	inorganic diphosphatase activity
AA314_06686	COG0515	serine threonine protein kinase
AA314_06689	COG1692	metallophosphoesterase
AA314_06690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AA314_06692	COG2135	peptidase activity
AA314_06695	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AA314_06699	COG3850	Histidine kinase
AA314_06699	COG5002	protein histidine kinase activity
AA314_06700	COG5002	protein histidine kinase activity
AA314_06703	COG1960	acyl-CoA dehydrogenase activity
AA314_06710	COG0604	alcohol dehydrogenase
AA314_06710	COG0604	alcohol dehydrogenase
AA314_06710	COG3321	synthase
AA314_06710	COG3321	synthase
AA314_06714	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA314_06716	COG2204	response regulator
AA314_06717	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA314_06718	COG1022	Amp-dependent synthetase and ligase
AA314_06720	COG0277	FAD linked oxidase domain protein
AA314_06721	COG0302	gtp cyclohydrolase
AA314_06727	COG1121	(ABC) transporter
AA314_06735	COG2319	Wd-40 repeat
AA314_06735	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_06736	COG2319	Wd-40 repeat
AA314_06736	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_06738	COG1672	PFAM Archaeal ATPase
AA314_06738	COG2319	Wd-40 repeat
AA314_06739	COG1335	isochorismatase
AA314_06740	COG0517	IMP dehydrogenase activity
AA314_06750	COG0670	Belongs to the BI1 family
AA314_06752	COG3411	Ferredoxin
AA314_06754	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA314_06758	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_06759	COG0297	glycogen (starch) synthase activity
AA314_06760	COG0438	transferase activity, transferring glycosyl groups
AA314_06761	COG4335	DNA alkylation repair
AA314_06762	COG0322	excinuclease ABC activity
AA314_06764	COG3620	sequence-specific DNA binding
AA314_06767	COG0515	serine threonine protein kinase
AA314_06767	COG2815	serine threonine protein kinase
AA314_06770	COG0795	lipopolysaccharide-transporting ATPase activity
AA314_06771	COG0151	Belongs to the GarS family
AA314_06773	COG0138	bifunctional purine biosynthesis protein purh
AA314_06774	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA314_06777	COG0515	serine threonine protein kinase
AA314_06785	COG0351	phosphomethylpyrimidine kinase
AA314_06787	COG4191	Histidine kinase
AA314_06790	COG0515	serine threonine protein kinase
AA314_06790	COG0457	Tetratricopeptide repeat
AA314_06791	COG4191	Histidine kinase
AA314_06792	COG3852	Histidine kinase
AA314_06794	COG0577	efflux transmembrane transporter activity
AA314_06794	COG1136	(ABC) transporter
AA314_06796	COG1136	(ABC) transporter
AA314_06798	COG2304	oxidoreductase activity
AA314_06803	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_06805	COG0840	transmembrane signaling receptor activity
AA314_06806	COG2890	protein-(glutamine-N5) methyltransferase activity
AA314_06807	COG1793	dna ligase
AA314_06814	COG1012	belongs to the aldehyde dehydrogenase family
AA314_06816	COG0583	DNA-binding transcription factor activity
AA314_06817	COG0427	acetyl-CoA hydrolase
AA314_06820	COG0840	transmembrane signaling receptor activity
AA314_06822	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_06826	COG0149	triose-phosphate isomerase activity
AA314_06827	COG0126	phosphoglycerate kinase activity
AA314_06828	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA314_06830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AA314_06832	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AA314_06838	COG0084	hydrolase, TatD family'
AA314_06840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA314_06840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA314_06845	COG0626	cystathionine gamma-synthase activity
AA314_06846	COG0626	cystathionine gamma-synthase activity
AA314_06847	COG2208	phosphoserine phosphatase activity
AA314_06848	COG0596	Alpha beta hydrolase
AA314_06849	COG1522	sequence-specific DNA binding
AA314_06855	COG2124	cytochrome p450
AA314_06868	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AA314_06875	COG0243	molybdopterin cofactor binding
AA314_06882	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA314_06884	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AA314_06884	COG1796	DNA polymerase
AA314_06889	COG0443	Heat shock 70 kDa protein
AA314_06891	COG0484	heat shock protein binding
AA314_06893	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA314_06894	COG1166	arginine decarboxylase activity
AA314_06903	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AA314_06904	COG0438	transferase activity, transferring glycosyl groups
AA314_06906	COG1408	metallophosphoesterase
AA314_06915	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AA314_06917	COG0613	PHP domain protein
AA314_06918	COG2124	cytochrome p450
AA314_06923	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA314_06924	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA314_06926	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA314_06927	COG0649	NAD binding
AA314_06928	COG1034	ATP synthesis coupled electron transport
AA314_06929	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA314_06930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA314_06943	COG3246	L-lysine catabolic process to acetate
AA314_06945	COG1309	transcriptional regulator
AA314_06947	COG1396	sequence-specific DNA binding
AA314_06951	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA314_06953	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_06954	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA314_06955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA314_06956	COG1683	Conserved Protein
AA314_06957	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AA314_06960	COG1309	transcriptional regulator
AA314_06963	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA314_06964	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA314_06971	COG1846	Transcriptional regulator
AA314_06974	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AA314_06976	COG1100	Small GTP-binding protein
AA314_06977	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA314_06995	COG2814	Major facilitator Superfamily
AA314_06999	COG1760	l-serine dehydratase
AA314_07006	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_07022	COG0596	Alpha beta hydrolase
AA314_07023	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AA314_07023	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AA314_07023	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AA314_07024	COG1105	Belongs to the carbohydrate kinase PfkB family
AA314_07025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA314_07025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA314_07026	COG1609	Transcriptional regulator
AA314_07027	COG0667	Aldo Keto reductase
AA314_07028	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_07028	COG1024	Enoyl-CoA hydratase
AA314_07029	COG1960	acyl-CoA dehydrogenase activity
AA314_07031	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AA314_07032	COG0352	thiamine-phosphate diphosphorylase activity
AA314_07034	COG0515	serine threonine protein kinase
AA314_07034	COG2815	serine threonine protein kinase
AA314_07037	COG4213	ABC transporter substrate-binding protein
AA314_07039	COG4214	carbohydrate transport
AA314_07043	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA314_07055	COG0312	modulator of DNA gyrase
AA314_07056	COG4221	oxidoreductase activity
AA314_07060	COG4681	YaeQ
AA314_07065	COG0586	Pfam SNARE associated Golgi protein
AA314_07068	COG0784	Response regulator, receiver
AA314_07077	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA314_07081	COG4191	Histidine kinase
AA314_07084	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA314_07085	COG0022	dehydrogenase e1 component
AA314_07085	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA314_07086	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA314_07089	COG0475	glutathione-regulated potassium exporter activity
AA314_07090	COG1396	sequence-specific DNA binding
AA314_07091	COG0475	glutathione-regulated potassium exporter activity
AA314_07094	COG0737	Belongs to the 5'-nucleotidase family
AA314_07100	COG0312	modulator of DNA gyrase
AA314_07101	COG0312	modulator of DNA gyrase
AA314_07102	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_07106	COG0181	hydroxymethylbilane synthase activity
AA314_07107	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA314_07108	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA314_07110	COG3118	belongs to the thioredoxin family
AA314_07113	COG2239	Acts as a magnesium transporter
AA314_07115	COG0772	Belongs to the SEDS family
AA314_07120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA314_07125	COG3706	GGDEF domain
AA314_07126	COG0424	maF-like protein
AA314_07136	COG0322	excinuclease ABC activity
AA314_07137	COG0556	nucleotide-excision repair
AA314_07140	COG0215	cysteine-tRNA ligase activity
AA314_07141	COG1716	ATPase activity
AA314_07143	COG1329	Transcriptional regulator
AA314_07144	COG0658	competence protein
AA314_07144	COG2333	competence protein COMEC
AA314_07149	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA314_07150	COG1074	ATP-dependent DNA helicase activity
AA314_07154	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_07163	COG1819	glycosyl
AA314_07174	COG3104	oligopeptide transport
AA314_07176	COG2226	methyltransferase
AA314_07179	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AA314_07188	COG0584	glycerophosphoryl diester phosphodiesterase
AA314_07190	COG1607	acyl-coa hydrolase
AA314_07191	COG2205	protein histidine kinase activity
AA314_07194	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA314_07196	COG0515	serine threonine protein kinase
AA314_07201	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AA314_07202	COG0732	type I restriction modification DNA specificity domain
AA314_07204	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AA314_07207	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA314_07212	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_07212	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_07217	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AA314_07220	COG3550	peptidyl-serine autophosphorylation
AA314_07223	COG0750	zinc metalloprotease
AA314_07225	COG0314	molybdopterin synthase activity
AA314_07229	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA314_07233	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA314_07235	COG1357	PFAM Pentapeptide repeats (8 copies)
AA314_07235	COG0515	serine threonine protein kinase
AA314_07236	COG1357	PFAM Pentapeptide repeats (8 copies)
AA314_07236	COG0515	serine threonine protein kinase
AA314_07238	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA314_07239	COG0750	zinc metalloprotease
AA314_07240	COG4589	Belongs to the CDS family
AA314_07241	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA314_07243	COG0564	pseudouridine synthase activity
AA314_07246	COG0617	tRNA 3'-terminal CCA addition
AA314_07248	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AA314_07249	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AA314_07252	COG0372	Belongs to the citrate synthase family
AA314_07253	COG2124	cytochrome p450
AA314_07258	COG0673	inositol 2-dehydrogenase activity
AA314_07265	COG0243	molybdopterin cofactor binding
AA314_07268	COG0437	4 iron, 4 sulfur cluster binding
AA314_07270	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AA314_07271	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_07274	COG1917	Cupin 2, conserved barrel domain protein
AA314_07275	COG0583	DNA-binding transcription factor activity
AA314_07276	COG0740	serine-type endopeptidase activity
AA314_07285	COG0416	fatty acid biosynthetic process
AA314_07292	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AA314_07293	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA314_07295	COG1063	alcohol dehydrogenase
AA314_07296	COG0596	Alpha beta hydrolase
AA314_07305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AA314_07315	COG2353	YceI-like domain
AA314_07316	COG0583	DNA-binding transcription factor activity
AA314_07317	COG1741	Belongs to the pirin family
AA314_07320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA314_07321	COG1858	cytochrome C peroxidase
AA314_07325	COG0612	Peptidase, M16
AA314_07327	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA314_07334	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_07335	COG0583	DNA-binding transcription factor activity
AA314_07345	COG1459	type II secretion system
AA314_07357	COG1595	DNA-templated transcription, initiation
AA314_07359	COG4990	cell redox homeostasis
AA314_07359	COG3591	Belongs to the peptidase S1B family
AA314_07361	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_07363	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA314_07365	COG0187	DNA topoisomerase II activity
AA314_07368	COG0616	signal peptide processing
AA314_07369	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AA314_07370	COG2267	carboxylic ester hydrolase activity
AA314_07373	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA314_07374	COG0516	GMP reductase activity
AA314_07374	COG0517	IMP dehydrogenase activity
AA314_07385	COG3973	AAA domain
AA314_07389	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA314_07393	COG0714	Associated with various cellular activities
AA314_07404	COG4305	rare lipoprotein A
AA314_07410	COG2204	response regulator
AA314_07411	COG2815	serine threonine protein kinase
AA314_07411	COG0515	serine threonine protein kinase
AA314_07424	COG1716	ATPase activity
AA314_07425	COG4789	Type iii secretion
AA314_07431	COG0490	domain, Protein
AA314_07431	COG0471	metal ion transport
AA314_07432	COG3273	potassium ion transport
AA314_07432	COG0471	metal ion transport
AA314_07443	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA314_07444	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA314_07447	COG1338	Plays a role in the flagellum-specific transport system
AA314_07449	COG1776	CheC inhibitor of MCP methylation
AA314_07449	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AA314_07452	COG1157	protein secretion by the type III secretion system
AA314_07453	COG1317	bacterial-type flagellum organization
AA314_07455	COG4669	(LipO)protein
AA314_07457	COG1191	sigma factor activity
AA314_07464	COG1136	(ABC) transporter
AA314_07466	COG1136	(ABC) transporter
AA314_07466	COG0577	efflux transmembrane transporter activity
AA314_07471	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AA314_07475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_07484	COG0456	acetyltransferase
AA314_07490	COG1187	pseudouridine synthase activity
AA314_07492	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA314_07493	COG0513	Belongs to the DEAD box helicase family
AA314_07494	COG0488	(ABC) transporter
AA314_07496	COG0488	(ABC) transporter
AA314_07497	COG0625	glutathione transferase activity
AA314_07499	COG0277	FAD linked oxidase domain protein
AA314_07502	COG1047	Peptidyl-prolyl cis-trans
AA314_07503	COG1301	dicarboxylic acid transport
AA314_07508	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA314_07514	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_07516	COG0596	Alpha beta hydrolase
AA314_07519	COG1960	acyl-CoA dehydrogenase activity
AA314_07520	COG0076	glutamate decarboxylase activity
AA314_07523	COG0515	serine threonine protein kinase
AA314_07523	COG2815	serine threonine protein kinase
AA314_07533	COG0631	protein serine/threonine phosphatase activity
AA314_07543	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_07544	COG4191	Histidine kinase
AA314_07545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_07549	COG1362	aminopeptidase activity
AA314_07557	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_07567	COG1045	serine acetyltransferase
AA314_07578	COG0515	serine threonine protein kinase
AA314_07580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_07582	COG0823	Involved in the tonB-independent uptake of proteins
AA314_07582	COG1506	peptidase
AA314_07584	COG2363	Small membrane protein
AA314_07586	COG2205	protein histidine kinase activity
AA314_07587	COG3850	Histidine kinase
AA314_07587	COG4999	Histidine kinase
AA314_07587	COG3437	response regulator, receiver
AA314_07587	COG2205	protein histidine kinase activity
AA314_07588	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_07590	COG1032	radical SAM domain protein
AA314_07592	COG0546	phosphoglycolate phosphatase activity
AA314_07595	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_07603	COG0745	RESPONSE REGULATOR receiver
AA314_07604	COG2201	protein-glutamate methylesterase activity
AA314_07606	COG0840	transmembrane signaling receptor activity
AA314_07608	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_07613	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA314_07623	COG2205	protein histidine kinase activity
AA314_07625	COG0300	oxidoreductase activity
AA314_07627	COG0628	permease
AA314_07639	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA314_07639	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_07642	COG0681	Belongs to the peptidase S26 family
AA314_07643	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA314_07645	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA314_07663	COG1404	Belongs to the peptidase S8 family
AA314_07669	COG1162	GTPase activity
AA314_07676	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA314_07681	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_07683	COG0823	Involved in the tonB-independent uptake of proteins
AA314_07686	COG2373	Large extracellular alpha-helical protein
AA314_07687	COG4953	penicillin-binding protein 1C
AA314_07688	COG0454	-acetyltransferase
AA314_07689	COG2226	methyltransferase
AA314_07692	COG0515	serine threonine protein kinase
AA314_07692	COG2815	serine threonine protein kinase
AA314_07697	COG3227	Zinc metalloprotease (Elastase)
AA314_07698	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_07703	COG2832	Protein of unknown function (DUF454)
AA314_07704	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_07715	COG1131	(ABC) transporter
AA314_07717	COG3118	belongs to the thioredoxin family
AA314_07718	COG2879	small protein
AA314_07719	COG1966	Carbon starvation protein
AA314_07741	COG0574	Belongs to the PEP-utilizing enzyme family
AA314_07741	COG3848	Pyruvate phosphate dikinase
AA314_07745	COG0515	serine threonine protein kinase
AA314_07745	COG2815	serine threonine protein kinase
AA314_07749	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AA314_07751	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_07758	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA314_07761	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA314_07761	COG2124	cytochrome p450
AA314_07764	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA314_07767	COG0395	ABC-type sugar transport system, permease component
AA314_07773	COG0423	glycine-tRNA ligase activity
AA314_07787	COG1960	acyl-CoA dehydrogenase activity
AA314_07788	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA314_07790	COG0840	transmembrane signaling receptor activity
AA314_07791	COG1012	belongs to the aldehyde dehydrogenase family
AA314_07797	COG0402	S-adenosylhomocysteine deaminase activity
AA314_07798	COG0515	serine threonine protein kinase
AA314_07801	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_07817	COG0300	oxidoreductase activity
AA314_07819	COG1733	regulation of RNA biosynthetic process
AA314_07820	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_07822	COG2226	methyltransferase
AA314_07828	COG0612	Peptidase, M16
AA314_07840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_07846	COG0840	transmembrane signaling receptor activity
AA314_07858	COG0697	spore germination
AA314_07863	COG0583	DNA-binding transcription factor activity
AA314_07867	COG2319	Wd-40 repeat
AA314_07867	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_07871	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_07874	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA314_07876	COG2815	serine threonine protein kinase
AA314_07876	COG0515	serine threonine protein kinase
AA314_07877	COG0756	dUTP diphosphatase activity
AA314_07878	COG0739	heme binding
AA314_07880	COG3344	reverse transcriptase
AA314_07882	COG1185	polyribonucleotide nucleotidyltransferase activity
AA314_07884	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA314_07889	COG0779	Required for maturation of 30S ribosomal subunits
AA314_07890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA314_07893	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AA314_07897	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA314_07898	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA314_07899	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA314_07900	COG1428	Deoxynucleoside kinase
AA314_07903	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA314_07904	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA314_07907	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AA314_07909	COG0631	protein serine/threonine phosphatase activity
AA314_07912	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA314_07917	COG0784	Response regulator, receiver
AA314_07917	COG5002	protein histidine kinase activity
AA314_07917	COG2198	Histidine kinase
AA314_07918	COG0745	RESPONSE REGULATOR receiver
AA314_07920	COG0339	signal peptide processing
AA314_07925	COG0583	DNA-binding transcription factor activity
AA314_07926	COG0823	Involved in the tonB-independent uptake of proteins
AA314_07926	COG1506	peptidase
AA314_07943	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA314_07945	COG0626	cystathionine gamma-synthase activity
AA314_07949	COG3030	protein affecting phage T7 exclusion by the F plasmid
AA314_07951	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA314_07954	COG1929	Belongs to the glycerate kinase type-1 family
AA314_07963	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AA314_07969	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AA314_07975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA314_07983	COG0745	RESPONSE REGULATOR receiver
AA314_07984	COG1024	Enoyl-CoA hydratase
AA314_07985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AA314_07986	COG0439	Biotin carboxylase
AA314_07989	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA314_07990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA314_07994	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_08004	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AA314_08005	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_08006	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA314_08007	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA314_08008	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA314_08009	COG0772	Belongs to the SEDS family
AA314_08010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA314_08011	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA314_08012	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AA314_08013	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA314_08015	COG3116	cell division
AA314_08016	COG0275	rRNA processing
AA314_08018	COG2001	Belongs to the MraZ family
AA314_08021	COG1960	acyl-CoA dehydrogenase activity
AA314_08032	COG0174	glutamine synthetase
AA314_08033	COG1012	belongs to the aldehyde dehydrogenase family
AA314_08034	COG0519	Catalyzes the synthesis of GMP from XMP
AA314_08034	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA314_08036	COG0628	permease
AA314_08038	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AA314_08040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA314_08041	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA314_08042	COG1254	Belongs to the acylphosphatase family
AA314_08044	COG1530	ribonuclease E activity
AA314_08044	COG1530	ribonuclease E activity
AA314_08045	COG1295	ribonuclease BN
AA314_08046	COG0776	regulation of translation
AA314_08048	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA314_08050	COG1987	bacterial-type flagellum assembly
AA314_08051	COG4790	Type iii secretion
AA314_08059	COG0745	RESPONSE REGULATOR receiver
AA314_08060	COG0577	efflux transmembrane transporter activity
AA314_08060	COG1136	(ABC) transporter
AA314_08069	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA314_08076	COG1136	(ABC) transporter
AA314_08084	COG0714	Associated with various cellular activities
AA314_08088	COG3541	Predicted nucleotidyltransferase
AA314_08094	COG3501	Rhs element vgr protein
AA314_08095	COG3501	Rhs element vgr protein
AA314_08102	COG5002	protein histidine kinase activity
AA314_08110	COG1215	transferase activity, transferring glycosyl groups
AA314_08111	COG0484	heat shock protein binding
AA314_08115	COG5507	3-demethylubiquinone-9 3-methyltransferase
AA314_08126	COG3279	Response regulator of the LytR AlgR family
AA314_08127	COG3275	phosphorelay sensor kinase activity
AA314_08128	COG0596	Alpha beta hydrolase
AA314_08130	COG0789	Transcriptional regulator
AA314_08131	COG2226	methyltransferase
AA314_08132	COG2124	cytochrome p450
AA314_08145	COG2239	Acts as a magnesium transporter
AA314_08149	COG1301	dicarboxylic acid transport
AA314_08154	COG0668	transmembrane transport
AA314_08157	COG1388	LysM domain
AA314_08157	COG1705	Flagellar rod assembly protein muramidase FlgJ
AA314_08166	COG0515	serine threonine protein kinase
AA314_08169	COG1136	(ABC) transporter
AA314_08169	COG0577	efflux transmembrane transporter activity
AA314_08175	COG0402	S-adenosylhomocysteine deaminase activity
AA314_08184	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA314_08186	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA314_08187	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_08196	COG0406	alpha-ribazole phosphatase activity
AA314_08196	COG0328	RNA-DNA hybrid ribonuclease activity
AA314_08198	COG0552	protein localization to endoplasmic reticulum
AA314_08205	COG1215	transferase activity, transferring glycosyl groups
AA314_08206	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_08208	COG2124	cytochrome p450
AA314_08218	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_08222	COG0753	catalase activity
AA314_08231	COG0793	Belongs to the peptidase S41A family
AA314_08233	COG4942	peptidase
AA314_08234	COG2177	Part of the ABC transporter FtsEX involved in
AA314_08235	COG2884	Cell division ATP-binding protein ftsE
AA314_08238	COG0471	metal ion transport
AA314_08241	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA314_08243	COG0811	peptide transport
AA314_08251	COG0248	Ppx GppA phosphatase
AA314_08253	COG1902	pentaerythritol trinitrate reductase activity
AA314_08254	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AA314_08256	COG1024	Enoyl-CoA hydratase
AA314_08264	COG2319	Wd-40 repeat
AA314_08264	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_08266	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_08268	COG3267	Type II secretory pathway component ExeA
AA314_08268	COG3409	Peptidoglycan-binding domain 1 protein
AA314_08270	COG0439	Biotin carboxylase
AA314_08271	COG0511	ligase activity, forming carbon-carbon bonds
AA314_08272	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA314_08280	COG2204	response regulator
AA314_08281	COG4191	Histidine kinase
AA314_08282	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AA314_08283	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA314_08285	COG1131	(ABC) transporter
AA314_08288	COG3852	Histidine kinase
AA314_08291	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_08292	COG0196	riboflavin kinase activity
AA314_08293	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA314_08294	COG3706	GGDEF domain
AA314_08294	COG0745	RESPONSE REGULATOR receiver
AA314_08305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA314_08307	COG0443	Heat shock 70 kDa protein
AA314_08309	COG1253	flavin adenine dinucleotide binding
AA314_08310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_08310	COG4191	Histidine kinase
AA314_08312	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AA314_08314	COG0793	Belongs to the peptidase S41A family
AA314_08317	COG0584	glycerophosphoryl diester phosphodiesterase
AA314_08318	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA314_08325	COG1192	Involved in chromosome partitioning
AA314_08332	COG5002	protein histidine kinase activity
AA314_08339	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA314_08340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AA314_08343	COG5002	protein histidine kinase activity
AA314_08344	COG5002	protein histidine kinase activity
AA314_08345	COG3850	Histidine kinase
AA314_08345	COG5002	protein histidine kinase activity
AA314_08348	COG4191	Histidine kinase
AA314_08349	COG0745	RESPONSE REGULATOR receiver
AA314_08352	COG0784	Response regulator, receiver
AA314_08352	COG2205	protein histidine kinase activity
AA314_08352	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_08352	COG2198	Histidine kinase
AA314_08353	COG4555	ABC transporter
AA314_08355	COG2766	serine protein kinase
AA314_08356	COG2718	Belongs to the UPF0229 family
AA314_08357	COG2719	SpoVR family
AA314_08358	COG0739	heme binding
AA314_08362	COG0058	SHG alpha-glucan phosphorylase activity
AA314_08365	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_08366	COG1024	Enoyl-CoA hydratase
AA314_08368	COG0587	DNA-directed DNA polymerase activity
AA314_08371	COG0667	Aldo Keto reductase
AA314_08374	COG0277	FAD linked oxidase domain protein
AA314_08375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AA314_08389	COG0515	serine threonine protein kinase
AA314_08390	COG0154	amidase activity
AA314_08396	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AA314_08402	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA314_08403	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA314_08418	COG0642	Histidine kinase
AA314_08419	COG2264	protein methyltransferase activity
AA314_08420	COG0531	amino acid
AA314_08421	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA314_08423	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA314_08428	COG0326	Molecular chaperone. Has ATPase activity
AA314_08442	COG3157	Type VI secretion system effector, Hcp
AA314_08451	COG2032	superoxide dismutase activity
AA314_08452	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_08454	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA314_08455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA314_08465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA314_08481	COG0667	Aldo Keto reductase
AA314_08497	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_08506	COG4941	Belongs to the sigma-70 factor family
AA314_08507	COG3620	sequence-specific DNA binding
AA314_08508	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA314_08509	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA314_08518	COG0183	Belongs to the thiolase family
AA314_08523	COG3118	belongs to the thioredoxin family
AA314_08526	COG0667	Aldo Keto reductase
AA314_08527	COG1012	belongs to the aldehyde dehydrogenase family
AA314_08529	COG0813	purine-nucleoside phosphorylase activity
AA314_08531	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_08533	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA314_08537	COG2032	superoxide dismutase activity
AA314_08539	COG0805	protein transport
AA314_08539	COG0805	protein transport
AA314_08540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA314_08544	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA314_08546	COG0625	glutathione transferase activity
AA314_08553	COG0300	oxidoreductase activity
AA314_08555	COG0564	pseudouridine synthase activity
AA314_08558	COG1793	dna ligase
AA314_08558	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA314_08568	COG2086	electron transfer activity
AA314_08569	COG1960	acyl-CoA dehydrogenase activity
AA314_08570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA314_08574	COG1595	DNA-templated transcription, initiation
AA314_08578	COG0564	pseudouridine synthase activity
AA314_08581	COG2124	cytochrome p450
AA314_08585	COG2124	cytochrome p450
AA314_08590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA314_08591	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA314_08592	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA314_08593	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA314_08597	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA314_08598	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA314_08600	COG0501	Belongs to the peptidase M48B family
AA314_08601	COG1295	ribonuclease BN
AA314_08603	COG0697	spore germination
AA314_08605	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA314_08606	COG2096	Adenosyltransferase
AA314_08607	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AA314_08608	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AA314_08611	COG0784	Response regulator, receiver
AA314_08612	COG4251	negative regulation of phosphorylation
AA314_08613	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_08614	COG1078	dGTPase activity
AA314_08615	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_08619	COG1331	Highly conserved protein containing a thioredoxin domain
AA314_08625	COG4974	Belongs to the 'phage' integrase family
AA314_08632	COG1695	Transcriptional regulator
AA314_08634	COG2326	polyphosphate kinase activity
AA314_08635	COG1196	nuclear chromosome segregation
AA314_08637	COG3227	Zinc metalloprotease (Elastase)
AA314_08644	COG2311	Membrane
AA314_08647	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA314_08648	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_08656	COG0596	Alpha beta hydrolase
AA314_08656	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA314_08658	COG0515	serine threonine protein kinase
AA314_08668	COG0037	tRNA processing
AA314_08669	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AA314_08676	COG0477	Major facilitator Superfamily
AA314_08679	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AA314_08682	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AA314_08683	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_08687	COG1131	(ABC) transporter
AA314_08691	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA314_08692	COG2197	response regulator
AA314_08695	COG4191	Histidine kinase
AA314_08699	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA314_08703	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA314_08706	COG2201	protein-glutamate methylesterase activity
AA314_08709	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_08711	COG2197	response regulator
AA314_08712	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA314_08714	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA314_08715	COG1278	Cold shock
AA314_08723	COG2267	carboxylic ester hydrolase activity
AA314_08736	COG0745	RESPONSE REGULATOR receiver
AA314_08737	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA314_08740	COG4771	TonB-dependent receptor
AA314_08742	COG2204	response regulator
AA314_08743	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AA314_08744	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA314_08749	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA314_08750	COG0134	indole-3-glycerol-phosphate synthase activity
AA314_08751	COG0135	phosphoribosylanthranilate isomerase activity
AA314_08752	COG0133	tryptophan synthase activity
AA314_08753	COG0159	tryptophan synthase activity
AA314_08756	COG0406	alpha-ribazole phosphatase activity
AA314_08757	COG2124	cytochrome p450
AA314_08765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA314_08767	COG0693	protein deglycase activity
AA314_08771	COG0300	oxidoreductase activity
AA314_08774	COG0437	4 iron, 4 sulfur cluster binding
AA314_08781	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA314_08782	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA314_08803	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_08806	COG0515	serine threonine protein kinase
AA314_08807	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_08807	COG4191	Histidine kinase
AA314_08809	COG1764	response to oxidative stress
AA314_08810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA314_08811	COG1846	Transcriptional regulator
AA314_08819	COG0438	transferase activity, transferring glycosyl groups
AA314_08822	COG1505	serine-type exopeptidase activity
AA314_08825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_08835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA314_08836	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AA314_08837	COG0469	pyruvate kinase activity
AA314_08849	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA314_08851	COG5001	Diguanylate cyclase
AA314_08858	COG3179	chitinase
AA314_08863	COG0515	serine threonine protein kinase
AA314_08863	COG2815	serine threonine protein kinase
AA314_08870	COG0402	S-adenosylhomocysteine deaminase activity
AA314_08875	COG3394	polysaccharide catabolic process
AA314_08876	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_08884	COG0069	glutamate synthase activity
AA314_08884	COG0067	glutamate synthase
AA314_08884	COG0070	glutamate synthase
AA314_08885	COG5002	protein histidine kinase activity
AA314_08886	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA314_08888	COG2815	serine threonine protein kinase
AA314_08888	COG0515	serine threonine protein kinase
AA314_08890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_08891	COG0745	RESPONSE REGULATOR receiver
AA314_08893	COG5002	protein histidine kinase activity
AA314_08895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA314_08896	COG0248	Ppx GppA phosphatase
AA314_08901	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AA314_08902	COG0300	oxidoreductase activity
AA314_08905	COG3234	Protein of unknown function (DUF1175)
AA314_08906	COG2373	Large extracellular alpha-helical protein
AA314_08907	COG4676	Protein conserved in bacteria
AA314_08908	COG2385	sporulation resulting in formation of a cellular spore
AA314_08915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA314_08919	COG0473	3-isopropylmalate dehydrogenase activity
AA314_08922	COG0326	Molecular chaperone. Has ATPase activity
AA314_08923	COG0023	Translation Initiation Factor
AA314_08924	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_08926	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA314_08928	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AA314_08929	COG0625	glutathione transferase activity
AA314_08935	COG0745	RESPONSE REGULATOR receiver
AA314_08936	COG5000	phosphorelay sensor kinase activity
AA314_08936	COG5002	protein histidine kinase activity
AA314_08938	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_08939	COG1136	(ABC) transporter
AA314_08940	COG0577	efflux transmembrane transporter activity
AA314_08940	COG1136	(ABC) transporter
AA314_08944	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_08951	COG0515	serine threonine protein kinase
AA314_08962	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA314_08964	COG0277	FAD linked oxidase domain protein
AA314_08983	COG0517	IMP dehydrogenase activity
AA314_08983	COG0516	GMP reductase activity
AA314_08984	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AA314_08985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA314_08990	COG1131	(ABC) transporter
AA314_08994	COG0741	lytic transglycosylase activity
AA314_08996	COG0363	glucosamine-6-phosphate deaminase activity
AA314_08998	COG3608	succinylglutamate desuccinylase aspartoacylase
AA314_08998	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA314_09001	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_09002	COG0676	glucose-6-phosphate 1-epimerase activity
AA314_09005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AA314_09015	COG4191	Histidine kinase
AA314_09016	COG5002	protein histidine kinase activity
AA314_09020	COG0438	transferase activity, transferring glycosyl groups
AA314_09026	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA314_09027	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA314_09029	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA314_09030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA314_09031	COG0456	acetyltransferase
AA314_09033	COG0667	Aldo Keto reductase
AA314_09036	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA314_09039	COG4783	chaperone-mediated protein folding
AA314_09047	COG0443	Heat shock 70 kDa protein
AA314_09050	COG1022	Amp-dependent synthetase and ligase
AA314_09052	COG0681	Belongs to the peptidase S26 family
AA314_09055	COG0737	Belongs to the 5'-nucleotidase family
AA314_09058	COG0740	serine-type endopeptidase activity
AA314_09070	COG0114	fumarate hydratase activity
AA314_09075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA314_09077	COG2224	Isocitrate lyase
AA314_09078	COG4717	serine-type aminopeptidase activity
AA314_09079	COG0420	3'-5' exonuclease activity
AA314_09082	COG1819	glycosyl
AA314_09083	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA314_09096	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA314_09099	COG2094	Belongs to the DNA glycosylase MPG family
AA314_09100	COG1640	4-alpha-glucanotransferase
AA314_09103	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_09111	COG2124	cytochrome p450
AA314_09125	COG1131	(ABC) transporter
AA314_09127	COG0714	Associated with various cellular activities
AA314_09132	COG1629	transport
AA314_09132	COG4206	TonB-dependent receptor
AA314_09135	COG0443	Heat shock 70 kDa protein
AA314_09159	COG2205	protein histidine kinase activity
AA314_09170	COG2885	chlorophyll binding
AA314_09172	COG1940	carbohydrate kinase activity
AA314_09176	COG0515	serine threonine protein kinase
AA314_09193	COG2204	response regulator
AA314_09195	COG1968	undecaprenyl-diphosphatase activity
AA314_09196	COG3012	SEC-C Motif Domain Protein
AA314_09208	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA314_09209	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA314_09215	COG0076	glutamate decarboxylase activity
AA314_09217	COG0745	RESPONSE REGULATOR receiver
AA314_09220	COG0306	phosphate transporter
AA314_09225	COG1285	pathogenesis
AA314_09226	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA314_09228	COG3716	PTS system mannose fructose sorbose family IID component
AA314_09230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AA314_09231	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA314_09232	COG1660	Displays ATPase and GTPase activities
AA314_09233	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AA314_09235	COG0537	adenosine 5'-monophosphoramidase activity
AA314_09238	COG0038	chloride channel
AA314_09240	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA314_09243	COG0723	plastoquinol--plastocyanin reductase activity
AA314_09250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA314_09251	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA314_09257	COG1596	polysaccharide export
AA314_09257	COG1555	photosystem II stabilization
AA314_09260	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA314_09263	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA314_09264	COG4208	sulfate ABC transporter
AA314_09265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA314_09266	COG2814	Major facilitator Superfamily
AA314_09267	COG1846	Transcriptional regulator
AA314_09271	COG2124	cytochrome p450
AA314_09273	COG3119	arylsulfatase activity
AA314_09276	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA314_09277	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA314_09282	COG2205	protein histidine kinase activity
AA314_09282	COG0784	Response regulator, receiver
AA314_09282	COG5002	protein histidine kinase activity
AA314_09284	COG0443	Heat shock 70 kDa protein
AA314_09286	COG0714	Associated with various cellular activities
AA314_09289	COG0745	RESPONSE REGULATOR receiver
AA314_09292	COG1472	Belongs to the glycosyl hydrolase 3 family
AA314_09296	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA314_09299	COG0745	RESPONSE REGULATOR receiver
AA314_09302	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA314_09302	COG0546	phosphoglycolate phosphatase activity
AA314_09306	COG3424	synthase
AA314_09317	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_09319	COG1755	Isoprenylcysteine carboxyl methyltransferase
AA314_09331	COG2204	response regulator
AA314_09346	COG2124	cytochrome p450
AA314_09347	COG3387	PFAM Glycoside hydrolase 15-related
AA314_09352	COG0745	RESPONSE REGULATOR receiver
AA314_09361	COG1215	transferase activity, transferring glycosyl groups
AA314_09369	COG0442	prolyl-tRNA aminoacylation
AA314_09380	COG4106	trans-aconitate 2-methyltransferase activity
AA314_09387	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA314_09390	COG0515	serine threonine protein kinase
AA314_09391	COG0443	Heat shock 70 kDa protein
AA314_09392	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA314_09402	COG4948	Mandelate Racemase Muconate Lactonizing
AA314_09408	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AA314_09409	COG1691	(AIR) carboxylase
AA314_09411	COG0366	Alpha amylase catalytic
AA314_09415	COG3833	ABC-type maltose transport systems, permease component
AA314_09418	COG3842	ATPase activity
AA314_09423	COG0643	Histidine kinase
AA314_09423	COG2198	Histidine kinase
AA314_09424	COG2201	protein-glutamate methylesterase activity
AA314_09425	COG0835	chemotaxis
AA314_09427	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AA314_09430	COG5002	protein histidine kinase activity
AA314_09431	COG1100	Small GTP-binding protein
AA314_09435	COG4191	Histidine kinase
AA314_09436	COG1199	ATP-dependent helicase activity
AA314_09438	COG2885	chlorophyll binding
AA314_09438	COG3047	cAMP biosynthetic process
AA314_09439	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AA314_09445	COG0546	phosphoglycolate phosphatase activity
AA314_09448	COG1597	lipid kinase activity
AA314_09450	COG2267	carboxylic ester hydrolase activity
AA314_09454	COG1420	regulation of RNA biosynthetic process
AA314_09459	COG0697	spore germination
AA314_09467	COG2133	pyrroloquinoline quinone binding
AA314_09469	COG0025	NhaP-type Na H and K H
AA314_09470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_09475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA314_09475	COG4651	solute:proton antiporter activity
AA314_09485	COG1120	ATPase activity
AA314_09489	COG0408	coproporphyrinogen oxidase activity
AA314_09499	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_09503	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA314_09504	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA314_09512	COG2264	protein methyltransferase activity
AA314_09513	COG2171	N-acyltransferase activity
AA314_09518	COG0076	glutamate decarboxylase activity
AA314_09520	COG1215	transferase activity, transferring glycosyl groups
AA314_09522	COG1077	Cell shape determining protein MreB Mrl
AA314_09524	COG0577	efflux transmembrane transporter activity
AA314_09524	COG1136	(ABC) transporter
AA314_09526	COG1136	(ABC) transporter
AA314_09539	COG0308	aminopeptidase N
AA314_09552	COG1132	(ABC) transporter
AA314_09553	COG1132	(ABC) transporter
AA314_09557	COG1668	transmembrane transport
AA314_09558	COG4555	ABC transporter
AA314_09561	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AA314_09565	COG3604	Transcriptional regulator
AA314_09576	COG0546	phosphoglycolate phosphatase activity
AA314_09577	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_09578	COG0545	Peptidyl-prolyl cis-trans isomerase
AA314_09582	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA314_09582	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA314_09583	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA314_09587	COG0546	phosphoglycolate phosphatase activity
AA314_09593	COG3852	Histidine kinase
AA314_09597	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_09606	COG2204	response regulator
AA314_09609	COG1160	GTP binding
AA314_09623	COG5002	protein histidine kinase activity
AA314_09624	COG2204	response regulator
AA314_09627	COG2201	protein-glutamate methylesterase activity
AA314_09628	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_09630	COG0835	chemotaxis
AA314_09631	COG0840	transmembrane signaling receptor activity
AA314_09632	COG0643	Histidine kinase
AA314_09632	COG2198	Histidine kinase
AA314_09633	COG0835	chemotaxis
AA314_09634	COG0840	transmembrane signaling receptor activity
AA314_09635	COG2204	response regulator
AA314_09636	COG4191	Histidine kinase
AA314_09641	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA314_09643	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_09646	COG0402	S-adenosylhomocysteine deaminase activity
AA314_09648	COG1505	serine-type exopeptidase activity
AA314_09653	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_09660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_09662	COG0537	adenosine 5'-monophosphoramidase activity
AA314_09664	COG1022	Amp-dependent synthetase and ligase
AA314_09670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_09672	COG0515	serine threonine protein kinase
AA314_09672	COG2815	serine threonine protein kinase
AA314_09674	COG1271	oxidase subunit
AA314_09679	COG1959	2 iron, 2 sulfur cluster binding
AA314_09681	COG2346	COG2346, Truncated hemoglobins
AA314_09682	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA314_09684	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA314_09685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA314_09688	COG2949	membrane
AA314_09694	COG3118	belongs to the thioredoxin family
AA314_09696	COG0673	inositol 2-dehydrogenase activity
AA314_09705	COG0135	phosphoribosylanthranilate isomerase activity
AA314_09706	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AA314_09708	COG2304	oxidoreductase activity
AA314_09713	COG0588	phosphoglycerate mutase activity
AA314_09721	COG2321	neutral zinc metallopeptidase
AA314_09723	COG0531	amino acid
AA314_09739	COG5002	protein histidine kinase activity
AA314_09740	COG0835	chemotaxis
AA314_09744	COG0840	transmembrane signaling receptor activity
AA314_09746	COG2201	protein-glutamate methylesterase activity
AA314_09747	COG5002	protein histidine kinase activity
AA314_09753	COG0835	chemotaxis
AA314_09754	COG0840	transmembrane signaling receptor activity
AA314_09755	COG0840	transmembrane signaling receptor activity
AA314_09756	COG2198	Histidine kinase
AA314_09756	COG0643	Histidine kinase
AA314_09759	COG0745	RESPONSE REGULATOR receiver
AA314_09761	COG1324	tolerance protein
AA314_09766	COG0542	response to heat
AA314_09775	COG5002	protein histidine kinase activity
AA314_09776	COG5464	transposase or invertase
AA314_09779	COG2198	Histidine kinase
AA314_09779	COG2205	protein histidine kinase activity
AA314_09779	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_09779	COG0784	Response regulator, receiver
AA314_09792	COG0534	Mate efflux family protein
AA314_09800	COG0443	Heat shock 70 kDa protein
AA314_09801	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA314_09809	COG2205	protein histidine kinase activity
AA314_09811	COG1309	transcriptional regulator
AA314_09818	COG0596	Alpha beta hydrolase
AA314_09825	COG0653	protein targeting
AA314_09826	COG0793	Belongs to the peptidase S41A family
AA314_09831	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA314_09840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_09851	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AA314_09892	COG1388	LysM domain
AA314_09893	COG1100	Small GTP-binding protein
AA314_09894	COG1960	acyl-CoA dehydrogenase activity
AA314_09897	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_09899	COG0583	DNA-binding transcription factor activity
AA314_09903	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AA314_09904	COG0010	Belongs to the arginase family
AA314_09907	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_09908	COG0412	Dienelactone hydrolase
AA314_09909	COG0545	Peptidyl-prolyl cis-trans isomerase
AA314_09910	COG5002	protein histidine kinase activity
AA314_09920	COG0745	RESPONSE REGULATOR receiver
AA314_09920	COG2205	protein histidine kinase activity
AA314_09920	COG4191	Histidine kinase
AA314_09921	COG3852	Histidine kinase
AA314_09923	COG0477	Major facilitator Superfamily
AA314_09937	COG1546	Belongs to the CinA family
AA314_09940	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_09941	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA314_09944	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AA314_09947	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA314_09951	COG1024	Enoyl-CoA hydratase
AA314_09954	COG1560	Kdo2-lipid A biosynthetic process
AA314_09957	COG3118	belongs to the thioredoxin family
AA314_09960	COG1446	asparaginase
AA314_09968	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_09968	COG0515	serine threonine protein kinase
AA314_09973	COG0589	response to stress
AA314_09977	COG5002	protein histidine kinase activity
AA314_09982	COG1051	belongs to the nudix hydrolase family
AA314_09982	COG1056	cytidyltransferase-related domain
AA314_09998	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA314_10015	COG0653	protein targeting
AA314_10017	COG2201	protein-glutamate methylesterase activity
AA314_10021	COG1858	cytochrome C peroxidase
AA314_10023	COG1268	BioY protein
AA314_10024	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AA314_10025	COG1122	ATPase activity
AA314_10026	COG1252	NADH dehydrogenase
AA314_10030	COG4191	Histidine kinase
AA314_10035	COG0625	glutathione transferase activity
AA314_10036	COG0154	amidase activity
AA314_10045	COG3591	Belongs to the peptidase S1B family
AA314_10050	COG3128	pkhd-type hydroxylase
AA314_10053	COG4774	siderophore transport
AA314_10055	COG3842	ATPase activity
AA314_10062	COG2204	response regulator
AA314_10063	COG2356	endonuclease I
AA314_10071	COG1653	transport
AA314_10072	COG2205	protein histidine kinase activity
AA314_10073	COG1278	Cold shock
AA314_10077	COG0745	RESPONSE REGULATOR receiver
AA314_10078	COG5002	protein histidine kinase activity
AA314_10084	COG1672	PFAM Archaeal ATPase
AA314_10084	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_10091	COG1672	PFAM Archaeal ATPase
AA314_10091	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_10102	COG2814	Major facilitator Superfamily
AA314_10108	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_10108	COG2319	Wd-40 repeat
AA314_10110	COG0243	molybdopterin cofactor binding
AA314_10111	COG0243	molybdopterin cofactor binding
AA314_10112	COG0243	molybdopterin cofactor binding