locus-tag	class	description
AACT_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AACT_0002	COG0592	DNA-directed DNA polymerase activity
AACT_0003	COG0187	DNA topoisomerase II activity
AACT_0004	COG0492	ferredoxin-NADP+ reductase activity
AACT_0005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AACT_0009	COG1238	metal cluster binding
AACT_0011	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AACT_0016	COG1053	succinate dehydrogenase
AACT_0017	COG0667	Aldo Keto reductase
AACT_0018	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AACT_0024	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AACT_0025	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AACT_0027	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AACT_0028	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AACT_0029	COG0633	Ferredoxin
AACT_0033	COG0716	FMN binding
AACT_0040	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AACT_0044	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AACT_0047	COG2207	Transcriptional regulator
AACT_0048	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AACT_0052	COG0426	domain, Protein
AACT_0059	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AACT_0065	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AACT_0066	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AACT_0067	COG0564	pseudouridine synthase activity
AACT_0068	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AACT_0069	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AACT_0070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AACT_0075	COG2954	triphosphatase activity
AACT_0078	COG0493	'glutamate synthase
AACT_0079	COG3047	cAMP biosynthetic process
AACT_0079	COG2885	chlorophyll binding
AACT_0081	COG0604	alcohol dehydrogenase
AACT_0082	COG1733	regulation of RNA biosynthetic process
AACT_0083	COG0390	transport system, permease component
AACT_0085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AACT_0086	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AACT_0091	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AACT_0092	COG1252	NADH dehydrogenase
AACT_0093	COG2030	dehydratase
AACT_0094	COG0659	secondary active sulfate transmembrane transporter activity
AACT_0095	COG1960	acyl-CoA dehydrogenase activity
AACT_0096	COG2181	nitrate reductase activity
AACT_0096	COG0247	lactate metabolic process
AACT_0098	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AACT_0099	COG0500	methyltransferase
AACT_0100	COG1250	3-hydroxyacyl-CoA dehydrogenase
AACT_0101	COG2050	protein possibly involved in aromatic compounds catabolism
AACT_0102	COG0824	Thioesterase
AACT_0105	COG0183	Belongs to the thiolase family
AACT_0108	COG0745	RESPONSE REGULATOR receiver
AACT_0109	COG5002	protein histidine kinase activity
AACT_0110	COG1556	Lactate utilization protein
AACT_0111	COG1139	Iron-sulfur cluster binding protein
AACT_0112	COG0247	lactate metabolic process
AACT_0114	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AACT_0114	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AACT_0115	COG0511	ligase activity, forming carbon-carbon bonds
AACT_0116	COG0439	Biotin carboxylase
AACT_0117	COG0513	Belongs to the DEAD box helicase family
AACT_0118	COG0306	phosphate transporter
AACT_0120	COG0367	asparagine synthase
AACT_0122	COG0778	Nitroreductase
AACT_0123	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AACT_0125	COG1053	succinate dehydrogenase
AACT_0127	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AACT_0128	COG1981	membrane
AACT_0129	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AACT_0129	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AACT_0130	COG1187	pseudouridine synthase activity
AACT_0131	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AACT_0131	COG0517	IMP dehydrogenase activity
AACT_0133	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AACT_0134	COG0107	imidazoleglycerol-phosphate synthase activity
AACT_0137	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AACT_0138	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AACT_0139	COG0724	RNA recognition motif
AACT_0140	COG0745	RESPONSE REGULATOR receiver
AACT_0141	COG0642	Histidine kinase
AACT_0146	COG2353	YceI-like domain
AACT_0148	COG3220	belongs to the UPF0276 family
AACT_0150	COG0534	Mate efflux family protein
AACT_0151	COG0460	homoserine dehydrogenase
AACT_0152	COG0436	Aminotransferase
AACT_0156	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AACT_0157	COG0254	rRNA binding
AACT_0158	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AACT_0161	COG3706	GGDEF domain
AACT_0163	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AACT_0164	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AACT_0165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AACT_0166	COG0237	dephospho-CoA kinase activity
AACT_0167	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AACT_0168	COG2992	FlgJ-related protein
AACT_0169	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AACT_0171	COG2353	YceI-like domain
AACT_0173	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AACT_0174	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AACT_0175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AACT_0177	COG0505	Belongs to the CarA family
AACT_0178	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AACT_0180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AACT_0180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AACT_0182	COG0489	protein tyrosine kinase activity
AACT_0183	COG0140	phosphoribosyl-ATP diphosphatase activity
AACT_0183	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AACT_0188	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AACT_0190	COG0646	methionine synthase
AACT_0190	COG1410	methionine synthase
AACT_0199	COG3339	Conserved Protein
AACT_0206	COG3647	Membrane
AACT_0207	COG1979	alcohol dehydrogenase
AACT_0213	COG1854	S-ribosylhomocysteine lyase activity
AACT_0215	COG1335	isochorismatase
AACT_0222	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AACT_0223	COG1127	ABC transporter
AACT_0227	COG3180	Ammonia monooxygenase
AACT_0234	COG1013	pyruvate-flavodoxin oxidoreductase activity
AACT_0235	COG0674	pyruvate-flavodoxin oxidoreductase activity
AACT_0237	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AACT_0238	COG0546	phosphoglycolate phosphatase activity
AACT_0240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AACT_0241	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AACT_0242	COG5002	protein histidine kinase activity
AACT_0242	COG3850	Histidine kinase
AACT_0243	COG0745	RESPONSE REGULATOR receiver
AACT_0245	COG0704	Plays a role in the regulation of phosphate uptake
AACT_0246	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AACT_0247	COG0581	inorganic phosphate transmembrane transporter activity
AACT_0248	COG0573	inorganic phosphate transmembrane transporter activity
AACT_0249	COG2199	diguanylate cyclase activity
AACT_0249	COG2200	EAL domain
AACT_0249	COG2203	Gaf domain
AACT_0250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AACT_0252	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AACT_0253	COG0268	Binds directly to 16S ribosomal RNA
AACT_0254	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AACT_0256	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AACT_0257	COG0746	molybdenum cofactor guanylyltransferase activity
AACT_0258	COG0446	pyridine nucleotide-disulphide oxidoreductase
AACT_0260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AACT_0261	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AACT_0262	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AACT_0263	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AACT_0270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AACT_0271	COG0736	holo-[acyl-carrier-protein] synthase activity
AACT_0272	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AACT_0273	COG3842	ATPase activity
AACT_0276	COG0395	ABC-type sugar transport system, permease component
AACT_0279	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AACT_0285	COG0469	pyruvate kinase activity
AACT_0286	COG1012	belongs to the aldehyde dehydrogenase family
AACT_0287	COG0166	Belongs to the GPI family
AACT_0289	COG0129	dihydroxy-acid dehydratase activity
AACT_0294	COG0575	Belongs to the CDS family
AACT_0295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AACT_0299	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AACT_0300	COG0023	Translation Initiation Factor
AACT_0303	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AACT_0303	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AACT_0304	COG2022	thiamine diphosphate biosynthetic process
AACT_0311	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AACT_0312	COG4120	Belongs to the binding-protein-dependent transport system permease family
AACT_0328	COG0659	secondary active sulfate transmembrane transporter activity
AACT_0333	COG1742	UPF0060 membrane protein
AACT_0338	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AACT_0340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AACT_0342	COG0640	Transcriptional regulator
AACT_0343	COG1346	cytolysis
AACT_0346	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AACT_0346	COG0519	Catalyzes the synthesis of GMP from XMP
AACT_0348	COG2084	Dehydrogenase
AACT_0349	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AACT_0363	COG3630	sodium ion export across plasma membrane
AACT_0364	COG0511	ligase activity, forming carbon-carbon bonds
AACT_0365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AACT_0366	COG3300	MHYT domain
AACT_0366	COG5001	Diguanylate cyclase
AACT_0375	COG0004	ammonium transporteR
AACT_0376	COG0347	Belongs to the P(II) protein family
AACT_0377	COG0004	ammonium transporteR
AACT_0379	COG0418	dihydroorotase activity
AACT_0380	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AACT_0381	COG1706	bacterial-type flagellum-dependent cell motility
AACT_0393	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AACT_0394	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AACT_0395	COG0601	transmembrane transport
AACT_0396	COG0736	holo-[acyl-carrier-protein] synthase activity
AACT_0397	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AACT_0399	COG0560	Phosphoserine phosphatase
AACT_0400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AACT_0401	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AACT_0402	COG1393	Belongs to the ArsC family
AACT_0403	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AACT_0404	COG0343	queuine tRNA-ribosyltransferase activity
AACT_0409	COG0436	Aminotransferase
AACT_0412	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AACT_0414	COG2861	carbohydrate metabolic process
AACT_0415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AACT_0416	COG0557	exoribonuclease II activity
AACT_0417	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AACT_0419	COG0360	Binds together with S18 to 16S ribosomal RNA
AACT_0420	COG0629	single-stranded DNA binding
AACT_0421	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AACT_0423	COG0215	cysteine-tRNA ligase activity
AACT_0424	COG0195	Participates in both transcription termination and antitermination
AACT_0426	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AACT_0427	COG2121	Domain of unknown function (DUF374)
AACT_0429	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AACT_0431	COG0288	reversible hydration of carbon dioxide
AACT_0432	COG0156	8-amino-7-oxononanoate synthase activity
AACT_0433	COG0792	nuclease activity
AACT_0437	COG0469	pyruvate kinase activity
AACT_0441	COG0745	RESPONSE REGULATOR receiver
AACT_0444	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AACT_0446	COG0540	Belongs to the ATCase OTCase family
AACT_0451	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AACT_0452	COG1687	branched-chain amino acid
AACT_0453	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AACT_0454	COG0416	fatty acid biosynthetic process
AACT_0455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AACT_0457	COG0105	UTP biosynthetic process
AACT_0459	COG0450	alkyl hydroperoxide reductase
AACT_0460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AACT_0461	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AACT_0462	COG2011	ABC-type metal ion transport system permease component
AACT_0464	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AACT_0465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AACT_0468	COG0181	hydroxymethylbilane synthase activity
AACT_0471	COG2828	Protein conserved in bacteria
AACT_0472	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AACT_0474	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AACT_0476	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AACT_0478	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AACT_0484	COG0514	ATP-dependent DNA helicase (RecQ)
AACT_0489	COG1451	nucleotide metabolic process
AACT_0490	COG2824	Alkylphosphonate utilization operon protein PhnA
AACT_0494	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AACT_0495	COG1053	succinate dehydrogenase
AACT_0497	COG1007	ATP synthesis coupled electron transport
AACT_0499	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AACT_0500	COG0713	ATP synthesis coupled electron transport
AACT_0501	COG0839	Belongs to the complex I subunit 6 family
AACT_0502	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AACT_0503	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AACT_0504	COG1034	ATP synthesis coupled electron transport
AACT_0505	COG0372	Belongs to the citrate synthase family
AACT_0508	COG0649	NAD binding
AACT_0508	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AACT_0509	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AACT_0510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AACT_0511	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AACT_0512	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AACT_0514	COG3610	response to peptide
AACT_0516	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AACT_0517	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AACT_0524	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AACT_0528	COG2151	metal-sulfur cluster biosynthetic enzyme
AACT_0531	COG1280	lysine exporter protein (LysE YggA)
AACT_0532	COG1126	abc transporter atp-binding protein
AACT_0533	COG0765	amino acid transport
AACT_0534	COG4597	amino acid ABC transporter
AACT_0535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AACT_0536	COG0840	transmembrane signaling receptor activity
AACT_0540	COG3043	anaerobic respiration
AACT_0541	COG0348	domain, Protein
AACT_0542	COG0437	4 iron, 4 sulfur cluster binding
AACT_0543	COG0243	molybdopterin cofactor binding
AACT_0546	COG1522	sequence-specific DNA binding
AACT_0550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AACT_0550	COG1648	precorrin-2 dehydrogenase activity
AACT_0552	COG0535	radical SAM domain protein
AACT_0559	COG3256	nitric oxide reductase
AACT_0564	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AACT_0565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AACT_0568	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AACT_0569	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AACT_0570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AACT_0572	COG2404	hydrolase activity, acting on ester bonds
AACT_0575	COG1832	CoA-binding protein
AACT_0576	COG0642	Histidine kinase
AACT_0577	COG0745	RESPONSE REGULATOR receiver
AACT_0578	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AACT_0579	COG0191	fructose-bisphosphate aldolase activity
AACT_0580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AACT_0586	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AACT_0593	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AACT_0594	COG2207	Transcriptional regulator
AACT_0599	COG3842	ATPase activity
AACT_0603	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AACT_0606	COG0535	radical SAM domain protein
AACT_0607	COG1280	lysine exporter protein (LysE YggA)
AACT_0610	COG2205	protein histidine kinase activity
AACT_0610	COG0784	Response regulator, receiver
AACT_0613	COG1278	Cold shock
AACT_0615	COG0811	peptide transport
AACT_0621	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AACT_0624	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AACT_0625	COG0442	prolyl-tRNA aminoacylation
AACT_0626	COG0668	transmembrane transport
AACT_0627	COG0617	tRNA 3'-terminal CCA addition
AACT_0630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AACT_0631	COG1862	Preprotein translocase
AACT_0632	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AACT_0633	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AACT_0637	COG0495	leucyl-tRNA aminoacylation
AACT_0639	COG0285	dihydrofolate synthase activity
AACT_0644	COG0784	Response regulator, receiver
AACT_0644	COG2205	protein histidine kinase activity
AACT_0653	COG1136	(ABC) transporter
AACT_0653	COG0577	efflux transmembrane transporter activity
AACT_0654	COG0577	efflux transmembrane transporter activity
AACT_0654	COG1136	(ABC) transporter
AACT_0665	COG1116	anion transmembrane transporter activity
AACT_0666	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AACT_0667	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AACT_0676	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AACT_0678	COG5001	Diguanylate cyclase
AACT_0678	COG4251	negative regulation of phosphorylation
AACT_0678	COG3706	GGDEF domain
AACT_0678	COG2203	Gaf domain
AACT_0680	COG0745	RESPONSE REGULATOR receiver
AACT_0681	COG0642	Histidine kinase
AACT_0682	COG2081	HI0933 family
AACT_0683	COG1692	metallophosphoesterase
AACT_0686	COG2226	methyltransferase
AACT_0687	COG1570	exodeoxyribonuclease VII activity
AACT_0691	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AACT_0693	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AACT_0694	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AACT_0696	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AACT_0697	COG0459	protein refolding
AACT_0698	COG5002	protein histidine kinase activity
AACT_0699	COG0745	RESPONSE REGULATOR receiver
AACT_0700	COG1408	metallophosphoesterase
AACT_0702	COG2353	YceI-like domain
AACT_0705	COG1136	(ABC) transporter
AACT_0707	COG0784	Response regulator, receiver
AACT_0707	COG3437	response regulator, receiver
AACT_0709	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AACT_0712	COG2962	Rard protein
AACT_0713	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AACT_0714	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AACT_0715	COG0352	thiamine-phosphate diphosphorylase activity
AACT_0716	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AACT_0718	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AACT_0719	COG2264	protein methyltransferase activity
AACT_0720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AACT_0721	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AACT_0725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AACT_0728	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AACT_0729	COG1090	epimerase
AACT_0730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AACT_0732	COG0481	GTPase activity
AACT_0735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AACT_0737	COG0482	sulfurtransferase activity
AACT_0738	COG0482	sulfurtransferase activity
AACT_0739	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AACT_0740	COG0006	proline dipeptidase activity
AACT_0741	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AACT_0742	COG0402	S-adenosylhomocysteine deaminase activity
AACT_0743	COG0616	signal peptide processing
AACT_0745	COG0280	phosphate acetyltransferase
AACT_0746	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AACT_0747	COG2176	DNA-directed DNA polymerase activity
AACT_0751	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AACT_0753	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AACT_0755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AACT_0757	COG0745	RESPONSE REGULATOR receiver
AACT_0758	COG5002	protein histidine kinase activity
AACT_0768	COG0579	oxidoreductase
AACT_0769	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AACT_0772	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AACT_0774	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AACT_0774	COG4191	Histidine kinase
AACT_0778	COG0714	Associated with various cellular activities
AACT_0779	COG0052	Belongs to the universal ribosomal protein uS2 family
AACT_0780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AACT_0781	COG1136	(ABC) transporter
AACT_0783	COG0194	GDP metabolic process
AACT_0784	COG5002	protein histidine kinase activity
AACT_0784	COG5001	Diguanylate cyclase
AACT_0785	COG2217	Heavy metal translocating P-type atpase
AACT_0788	COG4608	Belongs to the ABC transporter superfamily
AACT_0789	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AACT_0791	COG1355	regulation of microtubule-based process
AACT_0792	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AACT_0793	COG1121	(ABC) transporter
AACT_0794	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AACT_0797	COG2996	Protein conserved in bacteria
AACT_0798	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AACT_0799	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AACT_0802	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AACT_0803	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AACT_0804	COG0004	ammonium transporteR
AACT_0805	COG0347	Belongs to the P(II) protein family
AACT_0806	COG3706	GGDEF domain
AACT_0807	COG0210	DNA helicase
AACT_0808	COG0475	glutathione-regulated potassium exporter activity
AACT_0808	COG0569	domain protein
AACT_0809	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AACT_0814	COG3258	Cytochrome c
AACT_0823	COG1414	Transcriptional regulator
AACT_0824	COG0693	protein deglycase activity
AACT_0830	COG0525	valine-tRNA ligase activity
AACT_0837	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AACT_0839	COG2205	protein histidine kinase activity
AACT_0839	COG5002	protein histidine kinase activity
AACT_0839	COG0784	Response regulator, receiver
AACT_0842	COG2814	Major facilitator Superfamily
AACT_0843	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AACT_0847	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AACT_0849	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AACT_0850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AACT_0856	COG3447	MASE1 domain protein
AACT_0856	COG5001	Diguanylate cyclase
AACT_0856	COG5002	protein histidine kinase activity
AACT_0859	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AACT_0864	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AACT_0868	COG0439	Biotin carboxylase
AACT_0871	COG2166	iron-sulfur cluster assembly
AACT_0872	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AACT_0874	COG0396	ATPase activity
AACT_0875	COG0719	Fe-S assembly protein
AACT_0878	COG1366	Belongs to the anti-sigma-factor antagonist family
AACT_0878	COG2202	Pas domain
AACT_0879	COG0765	amino acid transport
AACT_0880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AACT_0885	COG2239	Acts as a magnesium transporter
AACT_0891	COG0165	Argininosuccinate lyase
AACT_0892	COG0784	Response regulator, receiver
AACT_0892	COG0835	chemotaxis
AACT_0893	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AACT_0894	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AACT_0895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AACT_0898	COG0556	nucleotide-excision repair
AACT_0899	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AACT_0902	COG4771	TonB-dependent receptor
AACT_0908	COG0698	ribose 5-phosphate isomerase
AACT_0909	COG0681	Belongs to the peptidase S26 family
AACT_0910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AACT_0913	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AACT_0914	COG0193	aminoacyl-tRNA hydrolase activity
AACT_0917	COG0860	N-Acetylmuramoyl-L-alanine amidase
AACT_0919	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AACT_0921	COG1758	RNA polymerase activity
AACT_0922	COG0528	UMP kinase activity
AACT_0924	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AACT_0925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AACT_0926	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AACT_0928	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AACT_0929	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AACT_0931	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AACT_0932	COG0305	Participates in initiation and elongation during chromosome replication
AACT_0949	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AACT_0956	COG0438	transferase activity, transferring glycosyl groups
AACT_0962	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
AACT_0963	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AACT_0966	COG1086	Polysaccharide biosynthesis protein
AACT_0969	COG1793	dna ligase
AACT_0970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AACT_0971	COG0133	tryptophan synthase activity
AACT_0973	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AACT_0975	COG0012	GTP binding
AACT_0979	COG3123	guanosine phosphorylase activity
AACT_0984	COG0585	pseudouridine synthase activity
AACT_0986	COG0840	transmembrane signaling receptor activity
AACT_0987	COG0632	four-way junction helicase activity
AACT_0988	COG1181	Belongs to the D-alanine--D-alanine ligase family
AACT_0990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AACT_0995	COG0051	transcription antitermination factor activity, RNA binding
AACT_0996	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AACT_0997	COG0088	Forms part of the polypeptide exit tunnel
AACT_0998	COG0089	rRNA binding
AACT_0999	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AACT_1000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AACT_1001	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AACT_1002	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AACT_1003	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AACT_1004	COG0255	Belongs to the universal ribosomal protein uL29 family
AACT_1005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AACT_1006	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AACT_1007	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AACT_1008	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AACT_1009	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AACT_1010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AACT_1011	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AACT_1012	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AACT_1013	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AACT_1014	COG0200	Binds to the 23S rRNA
AACT_1015	COG0201	protein transport
AACT_1016	COG0024	Methionine aminopeptidase
AACT_1017	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AACT_1019	COG1573	uracil-dna glycosylase
AACT_1021	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AACT_1024	COG1032	radical SAM domain protein
AACT_1025	COG0563	adenylate kinase activity
AACT_1026	COG0563	adenylate kinase activity
AACT_1029	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AACT_1030	COG0322	excinuclease ABC activity
AACT_1032	COG3706	GGDEF domain
AACT_1033	COG0386	Belongs to the glutathione peroxidase family
AACT_1034	COG0840	transmembrane signaling receptor activity
AACT_1035	COG0745	RESPONSE REGULATOR receiver
AACT_1037	COG2205	protein histidine kinase activity
AACT_1037	COG0784	Response regulator, receiver
AACT_1038	COG0840	transmembrane signaling receptor activity
AACT_1043	COG2326	polyphosphate kinase activity
AACT_1044	COG4456	Virulence-associated protein
AACT_1055	COG0829	nickel cation binding
AACT_1057	COG0832	Belongs to the urease beta subunit family
AACT_1057	COG0831	urea catabolic process
AACT_1058	COG0804	urea catabolic process
AACT_1059	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AACT_1061	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AACT_1072	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AACT_1078	COG0708	Exodeoxyribonuclease III
AACT_1083	COG4303	Ethanolamine ammonia lyase large subunit
AACT_1085	COG0531	amino acid
AACT_1088	COG0166	Belongs to the GPI family
AACT_1090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AACT_1097	COG2252	PERMEase
AACT_1098	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AACT_1100	COG2363	Small membrane protein
AACT_1103	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AACT_1104	COG2233	PERMEase
AACT_1105	COG1666	GTP binding
AACT_1107	COG0745	RESPONSE REGULATOR receiver
AACT_1108	COG0642	Histidine kinase
AACT_1111	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AACT_1112	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AACT_1113	COG0135	phosphoribosylanthranilate isomerase activity
AACT_1117	COG1013	pyruvate-flavodoxin oxidoreductase activity
AACT_1118	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AACT_1118	COG0674	pyruvate-flavodoxin oxidoreductase activity
AACT_1120	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AACT_1121	COG0727	PFAM Uncharacterised protein family (UPF0153)
AACT_1123	COG0134	indole-3-glycerol-phosphate synthase activity
AACT_1124	COG1942	4-Oxalocrotonate Tautomerase
AACT_1125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AACT_1126	COG0750	zinc metalloprotease
AACT_1127	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AACT_1128	COG1028	Short-chain dehydrogenase reductase Sdr
AACT_1129	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AACT_1132	COG0167	dihydroorotate dehydrogenase activity
AACT_1133	COG1132	(ABC) transporter
AACT_1134	COG0728	peptidoglycan biosynthetic process
AACT_1136	COG1592	Rubrerythrin
AACT_1137	COG1592	Rubrerythrin
AACT_1140	COG0530	calcium, potassium:sodium antiporter activity
AACT_1141	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AACT_1142	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AACT_1150	COG0552	protein localization to endoplasmic reticulum
AACT_1151	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AACT_1153	COG1418	mRNA catabolic process
AACT_1154	COG0742	ribosomal rna small subunit methyltransferase
AACT_1155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AACT_1156	COG0300	oxidoreductase activity
AACT_1162	COG0488	(ABC) transporter
AACT_1164	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AACT_1175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AACT_1176	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AACT_1177	COG0436	Aminotransferase
AACT_1178	COG1451	nucleotide metabolic process
AACT_1180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AACT_1181	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AACT_1182	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AACT_1182	COG0519	Catalyzes the synthesis of GMP from XMP
AACT_1185	COG2336	PFAM SpoVT AbrB
AACT_1188	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AACT_1191	COG1187	pseudouridine synthase activity
AACT_1192	COG3706	GGDEF domain
AACT_1194	COG1643	Atp-dependent helicase
AACT_1199	COG1187	pseudouridine synthase activity
AACT_1211	COG0697	spore germination
AACT_1223	COG0596	Alpha beta hydrolase
AACT_1227	COG0784	Response regulator, receiver
AACT_1227	COG2205	protein histidine kinase activity
AACT_1235	COG1484	DNA-dependent DNA replication
AACT_1236	COG4584	PFAM Integrase catalytic
AACT_1238	COG3852	Histidine kinase
AACT_1240	COG0784	Response regulator, receiver
AACT_1240	COG2205	protein histidine kinase activity
AACT_1243	COG0745	RESPONSE REGULATOR receiver
AACT_1245	COG1696	Membrane protein involved in D-alanine export
AACT_1250	COG0582	viral genome integration into host DNA
AACT_1254	COG0745	RESPONSE REGULATOR receiver
AACT_1256	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AACT_1258	COG2022	thiamine diphosphate biosynthetic process
AACT_1260	COG0642	Histidine kinase
AACT_1261	COG0745	RESPONSE REGULATOR receiver
AACT_1269	COG1696	Membrane protein involved in D-alanine export
AACT_1270	COG0564	pseudouridine synthase activity
AACT_1280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AACT_1281	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AACT_1282	COG2223	nitrite transmembrane transporter activity
AACT_1285	COG1028	Short-chain dehydrogenase reductase Sdr
AACT_1286	COG0519	Catalyzes the synthesis of GMP from XMP
AACT_1286	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AACT_1296	COG1253	flavin adenine dinucleotide binding
AACT_1297	COG2989	Protein conserved in bacteria
AACT_1302	COG0748	coenzyme F420 binding
AACT_1304	COG3422	double-strand break repair
AACT_1305	COG1253	flavin adenine dinucleotide binding
AACT_1308	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AACT_1310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AACT_1314	COG0513	Belongs to the DEAD box helicase family
AACT_1316	COG1045	serine acetyltransferase
AACT_1317	COG1166	arginine decarboxylase activity
AACT_1318	COG0124	histidyl-tRNA synthetase
AACT_1319	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AACT_1321	COG0163	prenyltransferase activity
AACT_1323	COG0359	binds to the 23S rRNA
AACT_1324	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AACT_1325	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AACT_1327	COG0084	hydrolase, TatD family'
AACT_1328	COG1388	LysM domain
AACT_1328	COG0741	lytic transglycosylase activity
AACT_1329	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AACT_1330	COG0131	Imidazoleglycerol-phosphate dehydratase
AACT_1331	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AACT_1334	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AACT_1335	COG0456	acetyltransferase
AACT_1340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AACT_1354	COG0849	cell division
AACT_1355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AACT_1358	COG2391	methyltransferase activity
AACT_1362	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AACT_1364	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AACT_1368	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AACT_1369	COG0732	type I restriction modification DNA specificity domain
AACT_1373	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AACT_1375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AACT_1382	COG3550	peptidyl-serine autophosphorylation
AACT_1384	COG0840	transmembrane signaling receptor activity
AACT_1388	COG0789	Transcriptional regulator
AACT_1389	COG0484	heat shock protein binding
AACT_1391	COG5002	protein histidine kinase activity
AACT_1393	COG2201	protein-glutamate methylesterase activity
AACT_1397	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AACT_1399	COG1696	Membrane protein involved in D-alanine export
AACT_1400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AACT_1404	COG0776	regulation of translation
AACT_1406	COG0275	rRNA processing
AACT_1414	COG4865	methylaspartate mutase activity
AACT_1420	COG4591	ABC-type transport system involved in lipoprotein release permease component
AACT_1421	COG0653	protein targeting
AACT_1430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AACT_1432	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AACT_1437	COG2195	Cleaves the N-terminal amino acid of tripeptides
AACT_1440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AACT_1440	COG1333	cytochrome c biogenesis protein
AACT_1441	COG0500	methyltransferase
AACT_1442	COG5001	Diguanylate cyclase
AACT_1442	COG4251	negative regulation of phosphorylation
AACT_1442	COG3706	GGDEF domain
AACT_1442	COG2203	Gaf domain
AACT_1443	COG5001	Diguanylate cyclase
AACT_1444	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AACT_1448	COG0133	tryptophan synthase activity
AACT_1451	COG0484	heat shock protein binding
AACT_1452	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AACT_1454	COG0840	transmembrane signaling receptor activity
AACT_1459	COG0189	ligase activity
AACT_1463	COG0137	argininosuccinate synthase activity
AACT_1465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AACT_1466	COG0802	atpase or kinase
AACT_1467	COG1137	ATPase activity
AACT_1468	COG3706	GGDEF domain
AACT_1469	COG3287	FIST C domain
AACT_1469	COG2200	EAL domain
AACT_1469	COG2199	diguanylate cyclase activity
AACT_1470	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AACT_1471	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AACT_1471	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AACT_1475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AACT_1476	COG2181	nitrate reductase activity
AACT_1476	COG0247	lactate metabolic process
AACT_1478	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AACT_1487	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AACT_1488	COG0805	protein transport
AACT_1489	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AACT_1494	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AACT_1495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AACT_1496	COG1663	tetraacyldisaccharide 4'-kinase activity
AACT_1498	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AACT_1499	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AACT_1500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AACT_1500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AACT_1503	COG0745	RESPONSE REGULATOR receiver
AACT_1505	COG0113	porphobilinogen synthase activity
AACT_1506	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AACT_1507	COG0357	Ribosomal RNA small subunit methyltransferase G
AACT_1514	COG1733	regulation of RNA biosynthetic process
AACT_1515	COG0778	Nitroreductase
AACT_1516	COG0300	oxidoreductase activity
AACT_1523	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AACT_1524	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AACT_1525	COG0511	ligase activity, forming carbon-carbon bonds
AACT_1526	COG3630	sodium ion export across plasma membrane
AACT_1529	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AACT_1529	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AACT_1531	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AACT_1536	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AACT_1537	COG0612	Peptidase, M16
AACT_1538	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AACT_1539	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AACT_1540	COG0287	Prephenate dehydrogenase
AACT_1541	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AACT_1544	COG0527	aspartate kinase activity
AACT_1545	COG0494	nUDIX hydrolase
AACT_1546	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AACT_1547	COG2890	protein-(glutamine-N5) methyltransferase activity
AACT_1548	COG0339	signal peptide processing
AACT_1552	COG0582	viral genome integration into host DNA
AACT_1553	COG2201	protein-glutamate methylesterase activity
AACT_1554	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AACT_1555	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AACT_1556	COG2198	Histidine kinase
AACT_1556	COG0643	Histidine kinase
AACT_1558	COG1185	polyribonucleotide nucleotidyltransferase activity
AACT_1560	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AACT_1564	COG0659	secondary active sulfate transmembrane transporter activity
AACT_1565	COG1160	GTP binding
AACT_1567	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AACT_1577	COG1196	nuclear chromosome segregation
AACT_1577	COG1674	ftsk spoiiie
AACT_1578	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AACT_1579	COG0440	acetolactate synthase activity
AACT_1580	COG0028	Belongs to the TPP enzyme family
AACT_1584	COG3706	GGDEF domain
AACT_1584	COG5001	Diguanylate cyclase
AACT_1584	COG2203	Gaf domain
AACT_1584	COG4251	negative regulation of phosphorylation
AACT_1588	COG0037	tRNA processing
AACT_1591	COG0303	'Molybdopterin
AACT_1593	COG5001	Diguanylate cyclase
AACT_1593	COG4251	negative regulation of phosphorylation
AACT_1593	COG3706	GGDEF domain
AACT_1593	COG2203	Gaf domain
AACT_1594	COG2321	neutral zinc metallopeptidase
AACT_1596	COG1322	Protein conserved in bacteria
AACT_1597	COG0501	Belongs to the peptidase M48B family
AACT_1599	COG0824	Thioesterase
AACT_1600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AACT_1601	COG0297	glycogen (starch) synthase activity
AACT_1602	COG0297	glycogen (starch) synthase activity
AACT_1604	COG1449	Belongs to the glycosyl hydrolase 57 family
AACT_1606	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AACT_1609	COG0837	glucose binding
AACT_1611	COG1136	(ABC) transporter
AACT_1613	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AACT_1617	COG0642	Histidine kinase
AACT_1618	COG0745	RESPONSE REGULATOR receiver
AACT_1622	COG0667	Aldo Keto reductase
AACT_1625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AACT_1626	COG0745	RESPONSE REGULATOR receiver
AACT_1627	COG0642	Histidine kinase
AACT_1633	COG1119	ATPase activity
AACT_1634	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AACT_1635	COG4206	TonB-dependent receptor
AACT_1639	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AACT_1640	COG0546	phosphoglycolate phosphatase activity
AACT_1643	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AACT_1644	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AACT_1646	COG5001	Diguanylate cyclase
AACT_1648	COG2949	membrane
AACT_1650	COG3706	GGDEF domain
AACT_1652	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AACT_1657	COG0419	ATPase involved in DNA repair
AACT_1660	COG0848	biopolymer transport protein
AACT_1661	COG0811	peptide transport
AACT_1662	COG0450	alkyl hydroperoxide reductase
AACT_1666	COG1342	Belongs to the UPF0251 family
AACT_1668	COG1271	oxidase subunit
AACT_1669	COG1294	oxidase, subunit
AACT_1672	COG0330	HflC and HflK could
AACT_1675	COG0745	RESPONSE REGULATOR receiver
AACT_1677	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AACT_1678	COG0788	formyltetrahydrofolate deformylase activity
AACT_1679	COG0281	malic enzyme
AACT_1679	COG0280	phosphate acetyltransferase
AACT_1683	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AACT_1686	COG0754	glutathionylspermidine amidase activity
AACT_1687	COG1607	acyl-coa hydrolase
AACT_1688	COG0488	(ABC) transporter
AACT_1690	COG0300	oxidoreductase activity
AACT_1695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AACT_1697	COG2200	EAL domain
AACT_1698	COG0840	transmembrane signaling receptor activity
AACT_1699	COG0840	transmembrane signaling receptor activity
AACT_1700	COG3046	protein related to deoxyribodipyrimidine photolyase
AACT_1703	COG3040	lipid binding
AACT_1705	COG2337	Toxic component of a toxin-antitoxin (TA) module
AACT_1709	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AACT_1712	COG0778	Nitroreductase
AACT_1713	COG0778	Nitroreductase
AACT_1716	COG1733	regulation of RNA biosynthetic process
AACT_1720	COG2855	membrane
AACT_1721	COG0583	DNA-binding transcription factor activity
AACT_1722	COG0697	spore germination
AACT_1723	COG0656	L-ascorbic acid biosynthetic process
AACT_1727	COG1119	ATPase activity
AACT_1728	COG1733	regulation of RNA biosynthetic process
AACT_1729	COG2814	Major facilitator Superfamily
AACT_1731	COG1794	racemase activity, acting on amino acids and derivatives
AACT_1734	COG1396	sequence-specific DNA binding
AACT_1740	COG2361	Protein of unknown function DUF86
AACT_1742	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AACT_1746	COG1193	negative regulation of DNA recombination
AACT_1749	COG0471	metal ion transport
AACT_1750	COG0521	Mo-molybdopterin cofactor biosynthetic process
AACT_1752	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AACT_1753	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AACT_1755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AACT_1756	COG0513	Belongs to the DEAD box helicase family
AACT_1757	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AACT_1759	COG3279	Response regulator of the LytR AlgR family
AACT_1764	COG0415	Belongs to the DNA photolyase family
AACT_1772	COG0642	Histidine kinase
AACT_1773	COG0745	RESPONSE REGULATOR receiver
AACT_1777	COG1132	(ABC) transporter
AACT_1778	COG0628	permease
AACT_1780	COG1472	Belongs to the glycosyl hydrolase 3 family
AACT_1785	COG1620	l-lactate permease
AACT_1786	COG0484	heat shock protein binding
AACT_1789	COG1047	Peptidyl-prolyl cis-trans
AACT_1794	COG0516	GMP reductase activity
AACT_1794	COG0517	IMP dehydrogenase activity
AACT_1795	COG0154	amidase activity
AACT_1796	COG0203	ribosomal protein L17
AACT_1797	COG0202	RNA polymerase activity
AACT_1798	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AACT_1799	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AACT_1800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AACT_1801	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AACT_1804	COG0473	3-isopropylmalate dehydrogenase activity
AACT_1805	COG0066	3-isopropylmalate dehydratase activity
AACT_1806	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AACT_1811	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AACT_1814	COG0772	Belongs to the SEDS family
AACT_1815	COG0564	pseudouridine synthase activity
AACT_1817	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AACT_1818	COG2884	Cell division ATP-binding protein ftsE
AACT_1821	COG1671	Belongs to the UPF0178 family
AACT_1823	COG0488	(ABC) transporter
AACT_1825	COG2171	N-acyltransferase activity
AACT_1826	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AACT_1831	COG2095	MarC family integral membrane protein
AACT_1832	COG0410	ABC transporter
AACT_1837	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AACT_1840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AACT_1841	COG0251	oxidation-reduction process
AACT_1844	COG0309	Hydrogenase expression formation protein (HypE)
AACT_1846	COG2084	Dehydrogenase
AACT_1847	COG0409	Hydrogenase expression formation protein
AACT_1848	COG0298	carbon dioxide binding
AACT_1849	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AACT_1856	COG2081	HI0933 family
AACT_1858	COG2354	Protein conserved in bacteria
AACT_1861	COG2814	Major facilitator Superfamily
AACT_1863	COG1858	cytochrome C peroxidase
AACT_1865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AACT_1865	COG0596	Alpha beta hydrolase
AACT_1865	COG2226	methyltransferase
AACT_1868	COG0471	metal ion transport
AACT_1868	COG3273	potassium ion transport
AACT_1870	COG0301	tRNA thio-modification
AACT_1870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AACT_1888	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AACT_1890	COG2207	Transcriptional regulator
AACT_1891	COG1979	alcohol dehydrogenase
AACT_1896	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AACT_1897	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AACT_1901	COG0469	pyruvate kinase activity
AACT_1902	COG1012	belongs to the aldehyde dehydrogenase family
AACT_1903	COG2188	Transcriptional regulator
AACT_1905	COG0039	L-malate dehydrogenase activity
AACT_1907	COG0800	Aldolase
AACT_1908	COG0129	dihydroxy-acid dehydratase activity
AACT_1909	COG0363	glucosamine-6-phosphate deaminase activity
AACT_1910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AACT_1913	COG3842	ATPase activity
AACT_1915	COG4209	transmembrane transport
AACT_1916	COG1653	transport
AACT_1917	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AACT_1919	COG0500	methyltransferase
AACT_1921	COG1049	propionate catabolic process, 2-methylcitrate cycle
AACT_1923	COG2203	Gaf domain
AACT_1923	COG4251	negative regulation of phosphorylation
AACT_1923	COG5001	Diguanylate cyclase
AACT_1923	COG3706	GGDEF domain
AACT_1926	COG1022	Amp-dependent synthetase and ligase
AACT_1927	COG0183	Belongs to the thiolase family
AACT_1928	COG1024	Enoyl-CoA hydratase
AACT_1928	COG1250	3-hydroxyacyl-CoA dehydrogenase
AACT_1932	COG5001	Diguanylate cyclase
AACT_1932	COG3300	MHYT domain
AACT_1934	COG0217	transcriptional regulatory protein
AACT_1939	COG1611	Belongs to the LOG family
AACT_1945	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AACT_1948	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AACT_1950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AACT_1955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AACT_1955	COG0475	glutathione-regulated potassium exporter activity
AACT_1960	COG0513	Belongs to the DEAD box helicase family
AACT_1965	COG1944	ATP diphosphatase activity
AACT_1970	COG0840	transmembrane signaling receptor activity
AACT_1971	COG0328	RNA-DNA hybrid ribonuclease activity
AACT_1972	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AACT_1975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AACT_1978	COG0446	pyridine nucleotide-disulphide oxidoreductase
AACT_1982	COG4662	Binding-protein-dependent transport system inner membrane component
AACT_1983	COG2998	abc-type tungstate transport system, permease component
AACT_1984	COG0303	'Molybdopterin
AACT_1988	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AACT_1990	COG0437	4 iron, 4 sulfur cluster binding
AACT_1998	COG0745	RESPONSE REGULATOR receiver
AACT_2001	COG1309	transcriptional regulator
AACT_2006	COG2353	YceI-like domain
AACT_2010	COG1305	Transglutaminase-like
AACT_2015	COG1921	L-seryl-tRNASec selenium transferase activity
AACT_2019	COG2204	response regulator
AACT_2036	COG0259	pyridoxamine-phosphate oxidase activity
AACT_2038	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AACT_2046	COG1984	allophanate hydrolase subunit 2
AACT_2047	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AACT_2051	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AACT_2052	COG4753	response regulator
AACT_2052	COG2207	Transcriptional regulator
AACT_2053	COG4191	Histidine kinase
AACT_2054	COG1611	Belongs to the LOG family
AACT_2055	COG2199	diguanylate cyclase activity
AACT_2060	COG0842	Transport permease protein
AACT_2061	COG0842	Transport permease protein
AACT_2061	COG1129	ABC transporter
AACT_2062	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AACT_2064	COG0326	Molecular chaperone. Has ATPase activity
AACT_2070	COG1216	Glycosyl transferase, family 2
AACT_2073	COG0753	catalase activity
AACT_2074	COG3008	intermembrane lipid transfer
AACT_2075	COG2995	paraquat-inducible protein a
AACT_2078	COG5001	Diguanylate cyclase
AACT_2078	COG5002	protein histidine kinase activity
AACT_2081	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AACT_2082	COG4335	DNA alkylation repair
AACT_2084	COG0010	Belongs to the arginase family
AACT_2086	COG2133	pyrroloquinoline quinone binding
AACT_2088	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AACT_2089	COG1227	inorganic diphosphatase activity
AACT_2090	COG2203	Gaf domain
AACT_2090	COG5001	Diguanylate cyclase
AACT_2090	COG3706	GGDEF domain
AACT_2090	COG4251	negative regulation of phosphorylation
AACT_2093	COG0579	oxidoreductase
AACT_2102	COG1027	Aspartate ammonia-lyase
AACT_2105	COG1115	amino acid carrier protein
AACT_2106	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AACT_2107	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AACT_2108	COG1047	Peptidyl-prolyl cis-trans
AACT_2111	COG0823	Involved in the tonB-independent uptake of proteins
AACT_2113	COG0848	biopolymer transport protein
AACT_2114	COG0811	peptide transport
AACT_2115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AACT_2116	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AACT_2117	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AACT_2118	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AACT_2119	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AACT_2120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AACT_2122	COG1475	DNA binding
AACT_2123	COG1192	Involved in chromosome partitioning
AACT_2127	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AACT_2128	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AACT_2129	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AACT_2130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AACT_2131	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AACT_2133	COG0358	DNA primase activity
AACT_2135	COG0571	ribonuclease III activity
AACT_2136	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AACT_2138	COG1686	Belongs to the peptidase S11 family
AACT_2139	COG0501	Belongs to the peptidase M48B family
AACT_2143	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AACT_2145	COG0706	membrane insertase activity
AACT_2146	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AACT_2147	COG0594	ribonuclease P activity
AACT_2148	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AACT_2149	COG0542	response to heat
AACT_2150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AACT_2151	COG3706	GGDEF domain
AACT_2154	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AACT_2155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AACT_2156	COG3437	response regulator, receiver
AACT_2157	COG3437	response regulator, receiver
AACT_2158	COG0784	Response regulator, receiver
AACT_2158	COG5002	protein histidine kinase activity
AACT_2159	COG0179	Fumarylacetoacetate (FAA) hydrolase
AACT_2162	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AACT_2165	COG0138	bifunctional purine biosynthesis protein purh
AACT_2168	COG4263	nitrous-oxide reductase activity
AACT_2171	COG0437	4 iron, 4 sulfur cluster binding
AACT_2174	COG0348	domain, Protein
AACT_2175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AACT_2177	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AACT_2179	COG0739	heme binding
AACT_2182	COG0598	Magnesium transport protein CorA
AACT_2187	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AACT_2188	COG0606	chelatase, subunit chli
AACT_2190	COG0242	peptide deformylase activity
AACT_2191	COG0740	serine-type endopeptidase activity
AACT_2192	COG0544	peptidyl-prolyl cis-trans isomerase activity
AACT_2193	COG2304	oxidoreductase activity
AACT_2194	COG2326	polyphosphate kinase activity
AACT_2197	COG1773	rubredoxin
AACT_2208	COG2258	MOSC domain
AACT_2209	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AACT_2213	COG1028	Short-chain dehydrogenase reductase Sdr
AACT_2214	COG2205	protein histidine kinase activity
AACT_2216	COG1773	rubredoxin
AACT_2222	COG1566	PFAM secretion protein HlyD family protein
AACT_2224	COG2205	protein histidine kinase activity
AACT_2225	COG0745	RESPONSE REGULATOR receiver
AACT_2228	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AACT_2229	COG1116	anion transmembrane transporter activity
AACT_2230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AACT_2231	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AACT_2232	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AACT_2247	COG0784	Response regulator, receiver
AACT_2247	COG4191	Histidine kinase
AACT_2250	COG0626	cystathionine gamma-synthase activity
AACT_2265	COG0745	RESPONSE REGULATOR receiver
AACT_2267	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AACT_2268	COG0803	Belongs to the bacterial solute-binding protein 9 family
AACT_2270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AACT_2271	COG1917	Cupin 2, conserved barrel domain protein
AACT_2271	COG2207	Transcriptional regulator
AACT_2274	COG1301	dicarboxylic acid transport
AACT_2275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AACT_2278	COG1309	transcriptional regulator
AACT_2279	COG1028	Short-chain dehydrogenase reductase Sdr
AACT_2285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AACT_2292	COG0668	transmembrane transport
AACT_2297	COG0351	phosphomethylpyrimidine kinase
AACT_2299	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AACT_2303	COG5002	protein histidine kinase activity
AACT_2304	COG4753	response regulator
AACT_2304	COG2207	Transcriptional regulator
AACT_2305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AACT_2306	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AACT_2314	COG0716	FMN binding
AACT_2317	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AACT_2320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AACT_2321	COG0159	tryptophan synthase activity
AACT_2322	COG0038	chloride channel
AACT_2325	COG1215	transferase activity, transferring glycosyl groups
AACT_2326	COG2379	hydroxypyruvate reductase
AACT_2327	COG3769	mannosylglycerate metabolic process
AACT_2328	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AACT_2329	COG2255	four-way junction helicase activity
AACT_2330	COG0628	permease
AACT_2332	COG4628	conserved protein (DUF2132)
AACT_2340	COG4175	Glycine betaine
AACT_2341	COG4176	ABC-type proline glycine betaine transport system permease component
AACT_2342	COG2113	Glycine betaine
AACT_2346	COG1733	regulation of RNA biosynthetic process
AACT_2347	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AACT_2351	COG0731	radical SAM domain protein
AACT_2352	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AACT_2354	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AACT_2357	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AACT_2359	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AACT_2362	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AACT_2364	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AACT_2366	COG0438	transferase activity, transferring glycosyl groups
AACT_2370	COG0438	transferase activity, transferring glycosyl groups
AACT_2371	COG0726	polysaccharide deacetylase
AACT_2372	COG0438	transferase activity, transferring glycosyl groups
AACT_2373	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AACT_2377	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AACT_2378	COG0483	inositol monophosphate 1-phosphatase activity
AACT_2380	COG0070	glutamate synthase
AACT_2380	COG0069	glutamate synthase activity
AACT_2380	COG0067	glutamate synthase
AACT_2383	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AACT_2384	COG0584	glycerophosphoryl diester phosphodiesterase
AACT_2386	COG0745	RESPONSE REGULATOR receiver
AACT_2392	COG2205	protein histidine kinase activity
AACT_2392	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AACT_2403	COG0284	orotidine-5'-phosphate decarboxylase activity
AACT_2404	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AACT_2405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AACT_2406	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AACT_2411	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AACT_2415	COG1739	Uncharacterized protein family UPF0029
AACT_2417	COG0196	riboflavin kinase activity
AACT_2418	COG2226	methyltransferase
AACT_2419	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AACT_2421	COG0277	FAD linked oxidase domain protein
AACT_2430	COG0542	response to heat
AACT_2431	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AACT_2432	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AACT_2435	COG2030	dehydratase
AACT_2439	COG0675	Transposase, IS605 OrfB family
AACT_2444	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AACT_2453	COG0745	RESPONSE REGULATOR receiver
AACT_2454	COG4786	Flagellar basal body rod
AACT_2458	COG1484	DNA-dependent DNA replication
AACT_2461	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AACT_2463	COG0228	four-way junction DNA binding
AACT_2464	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AACT_2465	COG0564	pseudouridine synthase activity
AACT_2466	COG1519	Transferase
AACT_2468	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AACT_2469	COG0752	glycyl-tRNA synthetase alpha subunit
AACT_2471	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AACT_2473	COG0826	peptidase U32
AACT_2476	COG0497	DNA recombination
AACT_2477	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AACT_2478	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AACT_2479	COG0049	tRNA binding
AACT_2480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AACT_2481	COG2814	Major facilitator Superfamily
AACT_2482	COG4895	conserved protein (DUF2196)
AACT_2489	COG3550	peptidyl-serine autophosphorylation
AACT_2490	COG3041	Addiction module toxin RelE StbE family
AACT_2499	COG3041	Addiction module toxin RelE StbE family
AACT_2522	COG0732	type I restriction modification DNA specificity domain
AACT_2526	COG0582	viral genome integration into host DNA
AACT_2529	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AACT_2530	COG0085	RNA polymerase activity
AACT_2531	COG0222	ribosome binding
AACT_2532	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AACT_2533	COG0081	regulation of translation
AACT_2534	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AACT_2535	COG0250	Participates in transcription elongation, termination and antitermination
AACT_2538	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AACT_2539	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AACT_2545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AACT_2546	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AACT_2547	COG0444	Belongs to the ABC transporter superfamily
AACT_2549	COG0174	glutamine synthetase
AACT_2551	COG0314	molybdopterin synthase activity
AACT_2553	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AACT_2554	COG1968	undecaprenyl-diphosphatase activity
AACT_2556	COG0772	Belongs to the SEDS family
AACT_2557	COG0768	penicillin binding
AACT_2558	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AACT_2559	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AACT_2562	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AACT_2564	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AACT_2567	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AACT_2569	COG2244	polysaccharide biosynthetic process
AACT_2570	COG0463	Glycosyl transferase, family 2
AACT_2570	COG1216	Glycosyl transferase, family 2
AACT_2571	COG0438	transferase activity, transferring glycosyl groups
AACT_2575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AACT_2594	COG0512	Glutamine amidotransferase of anthranilate synthase
AACT_2595	COG1840	ABC-type Fe3 transport system, periplasmic component
AACT_2596	COG1178	ABC-type Fe3 transport system permease component
AACT_2597	COG3842	ATPase activity
AACT_2609	COG2183	response to ionizing radiation
AACT_2610	COG2026	Addiction module toxin, RelE StbE family
AACT_2616	COG0251	oxidation-reduction process
AACT_2619	COG2095	MarC family integral membrane protein
AACT_2620	COG0765	amino acid transport
AACT_2628	COG0069	glutamate synthase activity
AACT_2629	COG1012	belongs to the aldehyde dehydrogenase family
AACT_2630	COG0410	ABC transporter
AACT_2639	COG0586	Pfam SNARE associated Golgi protein
AACT_2641	COG0335	large ribosomal subunit rRNA binding
AACT_2642	COG0336	Belongs to the RNA methyltransferase TrmD family
AACT_2646	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AACT_2647	COG0356	it plays a direct role in the translocation of protons across the membrane
AACT_2649	COG1074	ATP-dependent DNA helicase activity
AACT_2650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AACT_2651	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AACT_2653	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AACT_2655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AACT_2657	COG0303	'Molybdopterin
AACT_2658	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AACT_2660	COG0602	queuosine metabolic process
AACT_2662	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AACT_2664	COG0825	malonyl-CoA metabolic process
AACT_2665	COG0537	adenosine 5'-monophosphoramidase activity
AACT_2666	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AACT_2667	COG0072	phenylalanine-tRNA ligase activity
AACT_2667	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AACT_2668	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AACT_2669	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AACT_2670	COG0539	negative regulation of cytoplasmic translation
AACT_2670	COG1185	polyribonucleotide nucleotidyltransferase activity
AACT_2671	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AACT_2672	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AACT_2673	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AACT_2673	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AACT_2674	COG0779	Required for maturation of 30S ribosomal subunits
AACT_2675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AACT_2676	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AACT_2678	COG0083	homoserine kinase activity
AACT_2680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AACT_2683	COG0157	Belongs to the NadC ModD family
AACT_2685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AACT_2687	COG4773	Receptor
AACT_2689	COG4773	Receptor
AACT_2691	COG4115	mRNA cleavage
AACT_2692	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AACT_2700	COG3278	Belongs to the heme-copper respiratory oxidase family
AACT_2701	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AACT_2702	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AACT_2703	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AACT_2704	COG0210	DNA helicase
AACT_2706	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AACT_2706	COG3153	acetyltransferase
AACT_2707	COG1242	4 iron, 4 sulfur cluster binding
AACT_2708	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AACT_2709	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AACT_2710	COG0492	ferredoxin-NADP+ reductase activity
AACT_2711	COG3118	belongs to the thioredoxin family
AACT_2712	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AACT_2714	COG0791	NLP P60 protein
AACT_2716	COG0791	NLP P60 protein
AACT_2717	COG0791	NLP P60 protein
AACT_2720	COG0424	maF-like protein
AACT_2722	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AACT_2723	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AACT_2724	COG0077	Prephenate dehydratase
AACT_2724	COG1605	Chorismate mutase
AACT_2725	COG0019	diaminopimelate decarboxylase activity
AACT_2726	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AACT_2727	COG0149	triose-phosphate isomerase activity
AACT_2728	COG0126	phosphoglycerate kinase activity
AACT_2729	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AACT_2730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AACT_2732	COG0018	arginyl-trna synthetase
AACT_2733	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AACT_2734	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AACT_2735	COG0204	Acyl-transferase
AACT_2737	COG0047	phosphoribosylformylglycinamidine synthase activity
AACT_2738	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AACT_2739	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AACT_2740	COG0793	Belongs to the peptidase S41A family
AACT_2743	COG0585	pseudouridine synthase activity
AACT_2744	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AACT_2746	COG0577	efflux transmembrane transporter activity
AACT_2746	COG1136	(ABC) transporter
AACT_2748	COG0861	Integral membrane protein TerC family
AACT_2752	COG0450	alkyl hydroperoxide reductase
AACT_2753	COG3118	belongs to the thioredoxin family
AACT_2756	COG3706	GGDEF domain
AACT_2760	COG2205	protein histidine kinase activity
AACT_2776	COG0582	viral genome integration into host DNA
AACT_2780	COG0129	dihydroxy-acid dehydratase activity
AACT_2782	COG0745	RESPONSE REGULATOR receiver
AACT_2783	COG0642	Histidine kinase
AACT_2786	COG0702	epimerase
AACT_2787	COG1492	cobalamin metabolic process
AACT_2794	COG1028	Short-chain dehydrogenase reductase Sdr
AACT_2796	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AACT_2799	COG2095	MarC family integral membrane protein
AACT_2800	COG1083	cytidylyl-transferase
AACT_2800	COG2755	lipolytic protein G-D-S-L family
AACT_2801	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AACT_2803	COG5002	protein histidine kinase activity
AACT_2806	COG4232	protein-disulfide reductase activity
AACT_2808	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AACT_2809	COG0189	ligase activity
AACT_2809	COG4067	protein conserved in archaea
AACT_2811	COG0189	ligase activity
AACT_2814	COG2200	EAL domain
AACT_2814	COG3287	FIST C domain
AACT_2814	COG2199	diguanylate cyclase activity
AACT_2817	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AACT_2819	COG0443	Heat shock 70 kDa protein
AACT_2820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AACT_2821	COG1420	regulation of RNA biosynthetic process
AACT_2822	COG2358	TRAP transporter, solute receptor (TAXI family
AACT_2824	COG2197	response regulator
AACT_2826	COG0101	tRNA pseudouridine synthase activity
AACT_2828	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AACT_2829	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AACT_2830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AACT_2831	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AACT_2835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AACT_2836	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AACT_2838	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AACT_2839	COG0148	phosphopyruvate hydratase activity
AACT_2842	COG0475	glutathione-regulated potassium exporter activity
AACT_2842	COG0569	domain protein
AACT_2843	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AACT_2846	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AACT_2847	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AACT_2849	COG1007	ATP synthesis coupled electron transport
AACT_2851	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AACT_2852	COG0713	ATP synthesis coupled electron transport
AACT_2853	COG0839	Belongs to the complex I subunit 6 family
AACT_2854	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AACT_2855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AACT_2859	COG0649	NAD binding
AACT_2861	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AACT_2862	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AACT_2863	COG1222	aaa ATPase
AACT_2869	COG0659	secondary active sulfate transmembrane transporter activity
AACT_2871	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AACT_2872	COG1252	NADH dehydrogenase
AACT_2874	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AACT_2876	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AACT_2877	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AACT_2878	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AACT_2882	COG0445	tRNA wobble uridine modification
AACT_2888	COG0348	domain, Protein
AACT_2889	COG0504	CTP synthase activity
AACT_2890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AACT_2890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AACT_2893	COG0693	protein deglycase activity
AACT_2896	COG0587	DNA-directed DNA polymerase activity
AACT_2897	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AACT_2899	COG0582	viral genome integration into host DNA
AACT_2903	COG1484	DNA-dependent DNA replication
AACT_2921	COG1401	restriction endodeoxyribonuclease activity
AACT_2924	COG0315	cyclic pyranopterin monophosphate synthase activity
AACT_2925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AACT_2931	COG0670	Belongs to the BI1 family
AACT_2932	COG0352	thiamine-phosphate diphosphorylase activity
AACT_2934	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AACT_2936	COG0233	cytoplasmic translational termination
AACT_2937	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AACT_2939	COG2814	Major facilitator Superfamily
AACT_2941	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AACT_2941	COG3264	Mechanosensitive ion channel
AACT_2943	COG2239	Acts as a magnesium transporter
AACT_2945	COG3022	response to hydroperoxide
AACT_2947	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AACT_2949	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AACT_2951	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AACT_2952	COG1012	belongs to the aldehyde dehydrogenase family
AACT_2954	COG1704	LemA family
AACT_2957	COG0546	phosphoglycolate phosphatase activity
AACT_2963	COG2814	Major facilitator Superfamily
AACT_2967	COG2703	oxygen carrier activity
AACT_2972	COG0415	Belongs to the DNA photolyase family
AACT_2980	COG2081	HI0933 family
AACT_2987	COG1959	2 iron, 2 sulfur cluster binding
AACT_2991	COG0175	sulfate reduction
AACT_2993	COG2895	sulfate adenylyltransferase (ATP) activity
AACT_2994	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AACT_2995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AACT_2996	COG5001	Diguanylate cyclase
AACT_2996	COG2203	Gaf domain
AACT_2996	COG3706	GGDEF domain
AACT_2996	COG4251	negative regulation of phosphorylation
AACT_2997	COG1408	metallophosphoesterase
AACT_2998	COG0071	Belongs to the small heat shock protein (HSP20) family
AACT_3000	COG2308	Evidence 4 Homologs of previously reported genes of
AACT_3005	COG2308	Evidence 4 Homologs of previously reported genes of
AACT_3006	COG1217	gtp-binding protein TYPA
AACT_3017	COG0745	RESPONSE REGULATOR receiver
AACT_3018	COG2205	protein histidine kinase activity
AACT_3018	COG2770	Histidine kinase
AACT_3019	COG2391	methyltransferase activity
AACT_3020	COG0425	Belongs to the sulfur carrier protein TusA family
AACT_3026	COG2066	Belongs to the glutaminase family
AACT_3027	COG2860	membrane
AACT_3029	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AACT_3030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group