locus-tag class description AANAER_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AANAER_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AANAER_0003 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AANAER_0006 ENOG4105CQZ Histidine kinase AANAER_0008 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase AANAER_0012 ENOG4105E7U AraC family transcriptional regulator AANAER_0015 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AANAER_0020 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AANAER_0021 ENOG4108ZJ1 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AANAER_0023 ENOG4105CQM Urea amidohydrolase subunit alpha AANAER_0024 ENOG4108YZ9 Urea amidohydrolase subunit gamma AANAER_0025 ENOG4105C82 Malate synthase AANAER_0026 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AANAER_0028 ENOG4105DHG Allantoate amidinohydrolase AANAER_0032 ENOG410633P Hydantoin racemase AANAER_0033 ENOG4108IV0 ABC, transporter AANAER_0034 ENOG4105C0Z ABC transporter AANAER_0035 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AANAER_0036 ENOG4105C32 Amino acid ABC transporter (Permease) AANAER_0037 ENOG4105CP9 extracellular ligand-binding receptor AANAER_0039 ENOG4105C7J ABC transporter, permease AANAER_0040 ENOG4105D5T phosphonate abc transporter AANAER_0041 ENOG4108Z2U ureidoglycolate hydrolase AANAER_0042 ENOG4105CH5 extracellular solute-binding protein, family 7 AANAER_0044 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AANAER_0045 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AANAER_0048 ENOG4108IV0 ABC, transporter AANAER_0049 ENOG4105C0Z ABC transporter AANAER_0051 ENOG4105C32 Amino acid ABC transporter (Permease) AANAER_0056 ENOG4105BZU Histidine kinase AANAER_0057 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AANAER_0060 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_0061 ENOG4105BZU Histidine kinase AANAER_0062 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AANAER_0064 ENOG4108M5V ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AANAER_0067 ENOG4108JUA Transcriptional regulator AANAER_0068 ENOG41084IN nitrogen fixation protein AANAER_0069 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AANAER_0071 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AANAER_0073 ENOG4105ECW sulfate abc transporter AANAER_0075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AANAER_0076 ENOG4105E0C molybdate abc transporter AANAER_0078 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AANAER_0079 ENOG4105F4R Transcriptional regulator mode AANAER_0080 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain AANAER_0081 ENOG4105D0B Nitrogenase protein alpha chain AANAER_0083 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) AANAER_0084 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AANAER_0087 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AANAER_0088 ENOG4105KXW Ferredoxin AANAER_0091 ENOG4105R88 May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) AANAER_0092 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AANAER_0094 ENOG4108UR2 Nitrogen fixation protein NifX AANAER_0098 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AANAER_0100 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN AANAER_0102 ENOG4105DSF transport protein AANAER_0104 ENOG4105D0B Nitrogenase protein alpha chain AANAER_0106 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AANAER_0109 ENOG4105CNW domain protein AANAER_0113 ENOG4107S73 homocitrate synthase AANAER_0119 ENOG4105EI2 Pseudouridine synthase AANAER_0120 ENOG4107QTF adenylosuccinate lyase AANAER_0121 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AANAER_0122 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AANAER_0123 ENOG4108594 Permease of the drug metabolite transporter AANAER_0129 ENOG4108WHA ompa motb domain protein AANAER_0131 ENOG4105KJF protein tyrosine phosphatase AANAER_0132 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AANAER_0133 ENOG4107QKV phosphomannomutase AANAER_0134 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AANAER_0136 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AANAER_0138 ENOG4105KVH Transcriptional regulator AANAER_0140 ENOG4105KVH Transcriptional regulator AANAER_0142 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AANAER_0143 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AANAER_0144 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AANAER_0145 ENOG4107R3A FAD linked oxidase domain protein AANAER_0146 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AANAER_0148 ENOG4105CH5 extracellular solute-binding protein, family 7 AANAER_0149 ENOG4105EFQ Two component transcriptional regulator (Winged helix family AANAER_0150 ENOG4105BZU Histidine kinase AANAER_0151 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AANAER_0152 ENOG4107QR9 Iron-sulfur cluster binding protein AANAER_0153 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AANAER_0154 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AANAER_0155 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AANAER_0156 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AANAER_0157 ENOG4105C1J atp-dependent rna helicase AANAER_0160 ENOG4105CJ3 phosphate transporter AANAER_0162 ENOG4105CAQ asparagine synthetase AANAER_0165 ENOG4105CH5 extracellular solute-binding protein, family 7 AANAER_0167 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AANAER_0169 ENOG4105C5I Dehydrogenase AANAER_0170 ENOG4108IAB Phoh family AANAER_0171 ENOG4108YXA Membrane AANAER_0172 ENOG4105D1H recombination factor protein RarA AANAER_0173 ENOG4105FE9 pseudouridine synthase AANAER_0174 ENOG4105C2X Arabinose 5-phosphate isomerase AANAER_0175 ENOG4105CN5 Metallo-Beta-Lactamase AANAER_0176 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AANAER_0177 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AANAER_0180 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AANAER_0181 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AANAER_0189 ENOG4105GR3 Histidine kinase AANAER_0190 ENOG4105XJC Two component transcriptional regulator (Winged helix family AANAER_0191 ENOG4108YYC ycei family AANAER_0193 ENOG4105D6E homoserine dehydrogenase AANAER_0194 ENOG4105CHM Aminotransferase AANAER_0196 ENOG4105C2N RNA methyltransferase TrmH family group 3 AANAER_0198 ENOG41082DI 50s ribosomal protein l31 AANAER_0199 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AANAER_0200 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AANAER_0209 ENOG4105XJC Two component transcriptional regulator (Winged helix family AANAER_0210 ENOG4105ES5 Histidine kinase AANAER_0211 ENOG4107QY8 reductase AANAER_0212 ENOG4105QAX Iron-sulfur AANAER_0213 ENOG4107KGK dmso reductase anchor subunit AANAER_0214 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AANAER_0215 ENOG4105CHH sulfate transporter AANAER_0219 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AANAER_0220 ENOG4108UR8 BAX protein AANAER_0221 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AANAER_0222 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AANAER_0223 ENOG41084QV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AANAER_0224 ENOG4105CXB phosphoribosylaminoimidazole synthetase AANAER_0225 ENOG4105C2I pirin domain protein AANAER_0231 ENOG4107UUH Aminotransferase AANAER_0232 ENOG4105CYE ATP phosphoribosyltransferase regulatory subunit AANAER_0233 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AANAER_0235 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AANAER_0238 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AANAER_0240 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AANAER_0241 ENOG4105D1F ATP-binding protein AANAER_0242 ENOG41090R7 Ferric uptake AANAER_0243 ENOG4105D0S secretion protein (HlyD AANAER_0244 ENOG4105CJ1 ABC, transporter AANAER_0245 ENOG4105CMI transporter AANAER_0246 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AANAER_0249 ENOG4105CM2 brancheD-chain amino acid aminotransferase AANAER_0253 ENOG4108R5S membrane AANAER_0260 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) AANAER_0263 ENOG4105BZU Histidine kinase AANAER_0264 ENOG4105DDK oxidoreductase, beta subunit AANAER_0265 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AANAER_0266 ENOG4105WGB oxidoreductase, delta subunit AANAER_0267 ENOG4105EJ5 oxidoreductase gamma subunit AANAER_0269 ENOG4107XGZ Hydrolase AANAER_0272 ENOG4108UJD 30S ribosomal protein S9 AANAER_0273 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AANAER_0274 ENOG41062D9 Histidine kinase AANAER_0275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_0278 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AANAER_0279 ENOG4105E2Z phosphate ABC transporter (Permease AANAER_0280 ENOG4105C8U phosphate abc transporter AANAER_0282 ENOG4105PWN phosphate abc transporter AANAER_0283 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AANAER_0284 ENOG4108317 Binds directly to 16S ribosomal RNA (By similarity) AANAER_0285 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AANAER_0286 ENOG410813J This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AANAER_0287 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AANAER_0288 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AANAER_0289 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase AANAER_0294 ENOG4108J2R molybdopterin oxidoreductase AANAER_0295 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AANAER_0298 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AANAER_0299 ENOG41084M8 50s ribosomal protein L35 AANAER_0307 ENOG4105KNE Phosphatidate cytidylyltransferase AANAER_0308 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AANAER_0312 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AANAER_0314 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AANAER_0315 ENOG4105VF7 tolerance protein AANAER_0316 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AANAER_0319 ENOG4105W4W Transcriptional regulator AANAER_0329 ENOG4105C1P efflux transporter, rnd family, mfp subunit AANAER_0331 ENOG4108RMU ferritin dps family protein AANAER_0332 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AANAER_0334 ENOG4105BZE flagellar hook protein, FlgE AANAER_0337 ENOG4105CHC glucokinase (EC 2.7.1.2) AANAER_0339 ENOG4105C08 Histidine kinase AANAER_0342 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AANAER_0343 ENOG4105BZU Histidine kinase AANAER_0344 ENOG4105BZU Histidine kinase AANAER_0345 ENOG4108TX7 AANAER_0347 ENOG4105CN1 protease AANAER_0348 ENOG4105C8V SAICAR synthetase AANAER_0349 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AANAER_0350 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AANAER_0352 ENOG4105E9Q Acyl-transferase AANAER_0353 ENOG4105WMR Protein CrcB homolog AANAER_0354 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AANAER_0355 ENOG4105C75 arginyL-tRNA synthetase AANAER_0357 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AANAER_0359 ENOG4105BZA Phosphoglycerate kinase AANAER_0360 ENOG4105CP7 Triose-phosphate isomerase AANAER_0361 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AANAER_0362 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AANAER_0364 ENOG4105CQC Prephenate dehydratase AANAER_0365 ENOG4105CIH Imidazole acetol-phosphate transaminase AANAER_0366 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AANAER_0369 ENOG4107YJQ MAF-like protein AANAER_0372 ENOG4107TT5 NLP P60 protein AANAER_0373 ENOG4107TT5 NLP P60 protein AANAER_0375 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_0376 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_0378 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_0380 ENOG4105D65 subunit l AANAER_0381 ENOG4105RRV Inherit from COG: copper resistance AANAER_0382 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AANAER_0384 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AANAER_0385 ENOG4105BZU Histidine kinase AANAER_0386 ENOG4105XJC Two component transcriptional regulator (Winged helix family AANAER_0387 ENOG4105XJC Two component transcriptional regulator (Winged helix family AANAER_0388 ENOG4105BZU Histidine kinase AANAER_0389 ENOG4105HDK L-asparaginase AANAER_0390 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AANAER_0391 ENOG4108IJ0 Aspartate ammonia-lyase AANAER_0393 ENOG4105E33 succinate dehydrogenase AANAER_0394 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AANAER_0395 ENOG4108S24 Fumarate reduCtase AANAER_0396 ENOG4105BZG amino acid carrier protein AANAER_0397 ENOG4105C3M thioredoxin reductase AANAER_0398 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AANAER_0399 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AANAER_0400 ENOG4105N5T Radical SAM Protein AANAER_0401 ENOG4105DUM transcriptional regulator, lysR family AANAER_0402 ENOG4105C4R Atp-dependent dna helicase AANAER_0403 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AANAER_0404 ENOG4107Z7S Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AANAER_0405 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AANAER_0406 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AANAER_0413 ENOG4107RMM double-strand break repair protein Addb AANAER_0414 ENOG4105YIC Major outer membrane protein AANAER_0415 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AANAER_0417 ENOG4105YIC Major outer membrane protein AANAER_0419 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AANAER_0421 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AANAER_0424 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AANAER_0426 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AANAER_0428 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AANAER_0429 ENOG4105MGB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AANAER_0430 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AANAER_0431 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AANAER_0434 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AANAER_0435 ENOG4108JQ1 Dehydrogenase AANAER_0436 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AANAER_0437 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AANAER_0438 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AANAER_0439 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AANAER_0440 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AANAER_0442 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AANAER_0443 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AANAER_0444 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AANAER_0445 ENOG4105CHR reductase AANAER_0446 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AANAER_0448 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AANAER_0449 ENOG4105CVM Molybdenum cofactor synthesis domain protein AANAER_0454 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AANAER_0455 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AANAER_0456 ENOG4107QID Threonine synthase AANAER_0457 ENOG4105CAS nag kinase AANAER_0458 ENOG4105BZU Histidine kinase AANAER_0459 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AANAER_0461 ENOG4107WJT it plays a direct role in the translocation of protons across the membrane (By similarity) AANAER_0462 ENOG4105C7B Threonine dehydratase AANAER_0463 ENOG4106K80 AANAER_0464 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AANAER_0466 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AANAER_0467 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AANAER_0476 ENOG4105D3R alkyl hydroperoxide reductase AANAER_0477 ENOG4107T5V SNARE associated Golgi AANAER_0478 ENOG4105EMU Dehydrogenase AANAER_0480 ENOG4105CBS Chea signal transduction histidine kinase AANAER_0482 ENOG4107YTP response regulator receiver protein AANAER_0483 ENOG4105BZU Histidine kinase AANAER_0485 ENOG4107XM3 UPF0442 protein AANAER_0486 ENOG4105DWK Membrane AANAER_0488 ENOG4105BZU Histidine kinase AANAER_0491 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AANAER_0493 ENOG4108ZK4 sdia-regulated domain-containing protein AANAER_0494 ENOG4105BZU Histidine kinase AANAER_0495 ENOG4105C31 Tryptophanyl-tRNA synthetase AANAER_0499 ENOG4109015 Biopolymer transport protein exbD tolR AANAER_0509 ENOG4105CNM Receptor AANAER_0510 ENOG4107VQW regulatoR AANAER_0511 ENOG4108HGU Histidine kinase AANAER_0512 ENOG4108JYZ YitT family AANAER_0514 ENOG4105BZS acriflavin resistance protein AANAER_0515 ENOG4105CNM Receptor AANAER_0521 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AANAER_0522 ENOG4105BZU Histidine kinase AANAER_0524 ENOG4108MTB glycosyl transferase family AANAER_0526 ENOG4105CDA abc transporter atp-binding protein AANAER_0527 ENOG4105DRP amino acid AbC transporter AANAER_0528 ENOG4105EZ7 amino acid ABC transporter AANAER_0529 ENOG4107QXX ABC transporter AANAER_0531 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AANAER_0533 ENOG4105DKW ABC transporter AANAER_0534 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AANAER_0536 ENOG4108KA0 Inherit from COG: Phosphoesterase, DHHA1 AANAER_0537 ENOG4107B2H carbonic anhydrase AANAER_0538 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AANAER_0545 ENOG4105D5G Transposase AANAER_0546 ENOG4107SDU Methyl-accepting chemotaxis AANAER_0549 ENOG4105ETX regulatoR AANAER_0550 ENOG4105EIN peptidylprolyl cis-trans isomerase AANAER_0552 ENOG4109015 Biopolymer transport protein exbD tolR AANAER_0553 ENOG4108PAU MotA TolQ exbB proton channel AANAER_0555 ENOG4105BZU Histidine kinase AANAER_0556 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AANAER_0557 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AANAER_0560 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AANAER_0561 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AANAER_0563 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AANAER_0564 ENOG4105D64 Mechanosensitive ion channel AANAER_0565 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AANAER_0566 ENOG4105VIE preprotein translocase, subunit YajC AANAER_0567 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AANAER_0568 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AANAER_0572 ENOG4105C8T Leucyl-tRNA synthetase AANAER_0574 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AANAER_0575 ENOG4105DR5 peptidase AANAER_0578 ENOG4105CKD glutathione-regulated potassium-efflux system protein AANAER_0581 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AANAER_0582 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AANAER_0584 ENOG4105D05 Receptor AANAER_0588 ENOG41074H6 response regulator AANAER_0593 ENOG4108JA2 transcriptioN-repair coupling factor AANAER_0595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_0597 ENOG4105CBX hi0933 family AANAER_0598 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_0599 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AANAER_0600 ENOG410903D sensor protein AANAER_0601 ENOG4108HWS Histidine kinase AANAER_0602 ENOG4105D48 metallophosphoesterase AANAER_0607 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AANAER_0608 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_0609 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AANAER_0610 ENOG4108V3W Chemotaxis protein, CheW AANAER_0613 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AANAER_0615 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AANAER_0616 ENOG41084FT Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AANAER_0618 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AANAER_0619 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AANAER_0620 ENOG4105ECY inositol monophosphatase AANAER_0621 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AANAER_0622 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AANAER_0623 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AANAER_0624 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AANAER_0625 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AANAER_0627 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AANAER_0628 ENOG4107RQ5 Methylates ribosomal protein L11 (By similarity) AANAER_0629 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AANAER_0633 ENOG4105I03 Flagellin AANAER_0634 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AANAER_0636 ENOG4107SVH Potassium channel protein AANAER_0641 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AANAER_0643 ENOG4105BZU Histidine kinase AANAER_0644 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AANAER_0645 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AANAER_0646 ENOG4105BZU Histidine kinase AANAER_0647 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AANAER_0650 ENOG4105XJC Two component transcriptional regulator (Winged helix family AANAER_0653 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AANAER_0656 ENOG4105C59 p-type ATPase AANAER_0658 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AANAER_0659 ENOG4105CDV Ompa motb domain protein AANAER_0660 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AANAER_0661 ENOG4105EQ0 Major Facilitator superfamily AANAER_0662 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AANAER_0663 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AANAER_0664 ENOG4105DC7 peptidase M24 AANAER_0665 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AANAER_0666 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AANAER_0668 ENOG4105BZU Histidine kinase AANAER_0669 ENOG4105EFQ Two component transcriptional regulator (Winged helix family AANAER_0670 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) AANAER_0673 ENOG4108BGM Quinol dehydrogenase periplasmic component AANAER_0677 ENOG4105DA5 (ABC) transporter AANAER_0683 ENOG4105VG1 fes assembly suf system protein AANAER_0686 ENOG4105C1J atp-dependent rna helicase AANAER_0688 ENOG4108IJ2 phosphate acetyltransferase AANAER_0689 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AANAER_0690 ENOG4108IJ2 phosphate acetyltransferase AANAER_0691 ENOG4106492 Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO (By similarity) AANAER_0693 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AANAER_0694 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AANAER_0696 ENOG4107QN1 sodium solute AANAER_0698 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AANAER_0700 ENOG4107QN1 sodium solute AANAER_0702 ENOG4108STX response regulator AANAER_0703 ENOG4105BZU Histidine kinase AANAER_0712 ENOG4105CEV competence damage-inducible protein AANAER_0713 ENOG4107RSR Malate quinone oxidoreductase AANAER_0714 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AANAER_0717 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AANAER_0722 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AANAER_0723 ENOG4105CAY ferredoxin--nadp reductase AANAER_0724 ENOG4105CE9 30S ribosomal protein S2 AANAER_0725 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AANAER_0728 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AANAER_0729 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AANAER_0730 ENOG4105BZU Histidine kinase AANAER_0731 ENOG4105C59 p-type ATPase AANAER_0734 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) AANAER_0735 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AANAER_0738 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein AANAER_0739 ENOG4105FDK ABC transporter AANAER_0741 ENOG4105QNR S1 RNA binding domain protein AANAER_0742 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AANAER_0743 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_0744 ENOG4105ENA helicase AANAER_0745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AANAER_0747 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AANAER_0748 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AANAER_0749 ENOG4105BZS acriflavin resistance protein AANAER_0753 ENOG4107RDB Major Facilitator AANAER_0754 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AANAER_0759 ENOG410901F (LipO)protein AANAER_0760 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AANAER_0763 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AANAER_0766 ENOG4105BZU Histidine kinase AANAER_0767 ENOG4105D64 Mechanosensitive ion channel AANAER_0771 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AANAER_0773 ENOG4105BZU Histidine kinase AANAER_0793 ENOG4105CE1 Ferrous iron transport protein b AANAER_0794 ENOG4105XFK Ferrous iron transport protein A AANAER_0795 ENOG4105BZU Histidine kinase AANAER_0796 ENOG4105C94 Transporter AANAER_0800 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_0801 ENOG41084IH F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AANAER_0804 ENOG4105CHR reductase AANAER_0805 ENOG4108IG5 Transcriptional regulator AANAER_0808 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF AANAER_0809 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AANAER_0810 ENOG4105N80 Ferric uptake regulator, Fur family AANAER_0812 ENOG4105D7X high-affinity nickel-transporter AANAER_0813 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_0814 ENOG4105C3M thioredoxin reductase AANAER_0816 ENOG4105C28 cystathionine AANAER_0817 ENOG4105CNG UPF0061 protein AANAER_0818 ENOG4105CA0 peroxidase AANAER_0821 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AANAER_0823 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AANAER_0825 ENOG4105VG1 fes assembly suf system protein AANAER_0826 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AANAER_0827 ENOG4105C9B Cysteine desulfurase AANAER_0829 ENOG4105C3K feS assembly ATPase SufC AANAER_0831 ENOG4105DRP amino acid AbC transporter AANAER_0832 ENOG4105EAB amino acid AbC transporter AANAER_0833 ENOG4105C3J Cysteine desulfurase AANAER_0834 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) AANAER_0836 ENOG4105CH7 arginosuccinase AANAER_0838 ENOG4105CUZ uba thif-type nad fad binding protein AANAER_0839 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AANAER_0840 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AANAER_0843 ENOG4105CSR polyphosphate kinase 2 AANAER_0844 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AANAER_0845 ENOG4107SDU Methyl-accepting chemotaxis AANAER_0846 ENOG4105CSM endonuclease III AANAER_0847 ENOG4105BZU Histidine kinase AANAER_0848 ENOG4105BZU Histidine kinase AANAER_0860 ENOG4108YZG isomerase AANAER_0861 ENOG4105C3F Signal peptidase i AANAER_0862 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AANAER_0864 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AANAER_0865 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AANAER_0868 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AANAER_0870 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AANAER_0872 ENOG410692R Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AANAER_0873 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AANAER_0875 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AANAER_0876 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AANAER_0877 ENOG4105CRQ synthase (Component I) AANAER_0879 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AANAER_0880 ENOG4105CRK lysyL-tRNA synthetase AANAER_0882 ENOG4105BZU Histidine kinase AANAER_0883 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AANAER_0884 ENOG4105CDU Replicative dna helicase AANAER_0887 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AANAER_0888 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AANAER_0890 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AANAER_0891 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AANAER_0893 ENOG4105C3G gtp-binding protein AANAER_0896 ENOG4105NBK UPF0345 protein AANAER_0897 ENOG4105EFI regulatoR AANAER_0899 ENOG4105BZU Histidine kinase AANAER_0902 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AANAER_0904 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_0905 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AANAER_0906 ENOG4105CPF Cell wall formation (By similarity) AANAER_0908 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AANAER_0914 ENOG4107QMZ Dehydrogenase AANAER_0916 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) AANAER_0920 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AANAER_0921 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AANAER_0922 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AANAER_0923 ENOG4105KZZ One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AANAER_0924 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AANAER_0925 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AANAER_0926 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AANAER_0927 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AANAER_0928 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AANAER_0929 ENOG41084HJ 50s ribosomal protein l29 AANAER_0930 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AANAER_0931 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AANAER_0932 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AANAER_0934 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AANAER_0935 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AANAER_0936 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AANAER_0937 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AANAER_0938 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AANAER_0939 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AANAER_0940 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AANAER_0941 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AANAER_0942 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AANAER_0943 ENOG4106TD9 Diguanylate cyclase AANAER_0947 ENOG4105C9M aspartyl-trna synthetase AANAER_0950 ENOG4105CCT upf0313 protein AANAER_0951 ENOG4105C7Z Conserved Protein AANAER_0953 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AANAER_0957 ENOG4105CJW magnesium transporter AANAER_0959 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AANAER_0960 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AANAER_0962 ENOG4105BZU Histidine kinase AANAER_0966 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AANAER_0967 ENOG4105D5G Transposase AANAER_0973 ENOG4105K56 Transcriptional regulator AANAER_0974 ENOG4105ETP RND efflux system, outer membrane lipoprotein AANAER_0976 ENOG4105ZQC membrane protein AaeX AANAER_0978 ENOG4105EGI Transcriptional regulator AANAER_0982 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AANAER_0984 ENOG4108V06 Glutathione peroxidase AANAER_0993 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AANAER_1001 ENOG4108WC9 type VI secretion system effector, hcp1 family AANAER_1015 ENOG4105NVB glycoside hydrolase, family 19 AANAER_1021 ENOG4105D5G Transposase AANAER_1023 ENOG4105DR5 peptidase AANAER_1027 ENOG4105E6M Sulphatase-modifying factor protein AANAER_1029 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AANAER_1031 ENOG4107TUY Histidine kinase AANAER_1032 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AANAER_1036 ENOG4105CA0 peroxidase AANAER_1037 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_1038 ENOG4105CGK Exodeoxyribonuclease III AANAER_1043 ENOG4105BZU Histidine kinase AANAER_1044 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family AANAER_1048 ENOG4107QWP ABC-2 type transporter AANAER_1049 ENOG4107QWP ABC-2 type transporter AANAER_1050 ENOG4105CJ1 ABC, transporter AANAER_1051 ENOG4105D0S secretion protein (HlyD AANAER_1053 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AANAER_1054 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AANAER_1055 ENOG4105BZU Histidine kinase AANAER_1058 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AANAER_1063 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) AANAER_1064 ENOG4105F1N DNA alkylation repair AANAER_1065 ENOG4108Z66 YbaK ebsC protein AANAER_1066 ENOG4105C7I Dehydrogenase AANAER_1068 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AANAER_1075 ENOG4105E7W lamb ycsf family protein AANAER_1079 ENOG4105BZU Histidine kinase AANAER_1081 ENOG4105C1J atp-dependent rna helicase AANAER_1082 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AANAER_1084 ENOG4105DCI Phosphohydrolase AANAER_1087 ENOG4105CVE Lytic murein transglycosylase AANAER_1089 ENOG4107QX9 Thiol disulfide interChange protein AANAER_1094 ENOG4105CHM Aminotransferase AANAER_1095 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AANAER_1097 ENOG4108URH decarboxylase AANAER_1102 ENOG4105CDY transcriptional regulatory protein AANAER_1104 ENOG4108UZ3 Transporter AANAER_1106 ENOG4107QIJ Aconitate hydratase 2 AANAER_1110 ENOG4105E3S small subunit AANAER_1111 ENOG4105DPX Hydrogenase, large subunit AANAER_1115 ENOG4105E3S small subunit AANAER_1116 ENOG4105DPX Hydrogenase, large subunit AANAER_1117 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit AANAER_1118 ENOG4108USZ hydrogenase AANAER_1122 ENOG4105C8J )-transporter AANAER_1123 ENOG4105VCH membrane AANAER_1125 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AANAER_1126 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF AANAER_1127 ENOG4105CQS hydrogenase expression formation protein HypD AANAER_1129 ENOG4105C45 hydrogenase expression formation protein (HypE) AANAER_1130 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AANAER_1132 ENOG4105C32 Amino acid ABC transporter (Permease) AANAER_1133 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AANAER_1134 ENOG4105C0Z ABC transporter AANAER_1135 ENOG4108IV0 ABC, transporter AANAER_1140 ENOG4105C25 Primosomal protein n' AANAER_1141 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AANAER_1142 ENOG4105BZU Histidine kinase AANAER_1145 ENOG4105CAK Cell division ATP-binding protein ftsE AANAER_1146 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AANAER_1147 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AANAER_1148 ENOG4105C34 Pseudouridine synthase AANAER_1149 ENOG4105CNI cell division protein FtsW AANAER_1150 ENOG4105CYW agmatinase AANAER_1155 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AANAER_1156 ENOG4105NBK UPF0345 protein AANAER_1160 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AANAER_1161 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AANAER_1162 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AANAER_1164 ENOG41067V7 50S ribosomal protein L36 AANAER_1165 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AANAER_1166 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AANAER_1167 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AANAER_1168 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AANAER_1169 ENOG4108ZT0 50S ribosomal protein l17 AANAER_1170 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AANAER_1171 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AANAER_1183 ENOG410829K Lysine exporter protein (Lyse ygga) AANAER_1190 ENOG4105C4R Atp-dependent dna helicase AANAER_1191 ENOG4105C0R drug resistance transporter emrb qaca subfamily AANAER_1192 ENOG4105CW7 secretion protein, HlyD family AANAER_1193 ENOG4105J7D transcriptional regulator AANAER_1195 ENOG41082W1 Cupin 2, conserved barrel domain protein AANAER_1196 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AANAER_1197 ENOG4105DB1 molybdopterin oxidoreductase AANAER_1199 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AANAER_1201 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AANAER_1202 ENOG4108YZY peptidylprolyl cis-trans isomerase AANAER_1203 ENOG4108YZY peptidylprolyl cis-trans isomerase AANAER_1204 ENOG4108URH decarboxylase AANAER_1208 ENOG410829K Lysine exporter protein (Lyse ygga) AANAER_1209 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AANAER_1212 ENOG4105DWV Homoserine O-trans-acetylase AANAER_1223 ENOG4105DZR Type I site-specific deoxyribonuclease AANAER_1224 ENOG4105D06 uba thif-type nad fad binding protein AANAER_1225 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AANAER_1228 ENOG4105C42 Type I secretion membrane fusion protein (HlyD AANAER_1230 ENOG4108JJA ABC, transporter AANAER_1233 ENOG4105BZU Histidine kinase AANAER_1235 ENOG4108WHA ompa motb domain protein AANAER_1237 ENOG4105C42 Type I secretion membrane fusion protein (HlyD AANAER_1238 ENOG41061ZR Transcriptional regulator AANAER_1251 ENOG41074H6 response regulator AANAER_1253 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AANAER_1254 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding AANAER_1259 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) AANAER_1263 ENOG4108JNI Alpha beta hydrolase AANAER_1266 ENOG4105CQC Prephenate dehydratase AANAER_1267 ENOG4105E0M Sulfatase AANAER_1274 ENOG4105D49 3-dehydroquinate synthase AANAER_1276 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AANAER_1279 ENOG4108RIR Molybdenum cofactor biosynthesis protein AANAER_1280 ENOG4105C8P )-transporter AANAER_1283 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AANAER_1284 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_1285 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AANAER_1286 ENOG4105C98 muts2 protein AANAER_1290 ENOG4105DUM transcriptional regulator, lysR family AANAER_1291 ENOG4105HMI Membrane AANAER_1292 ENOG4105HF0 Membrane AANAER_1293 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AANAER_1296 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1299 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AANAER_1301 ENOG4105BZU Histidine kinase AANAER_1303 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AANAER_1305 ENOG4105KAC Antibiotic biosynthesis monooxygenase AANAER_1311 ENOG4105D3R alkyl hydroperoxide reductase AANAER_1315 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AANAER_1317 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AANAER_1320 ENOG4108V1U phospholipid-binding protein AANAER_1325 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AANAER_1326 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AANAER_1327 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_1332 ENOG4105KVH Transcriptional regulator AANAER_1334 ENOG4105NF4 modulator of drug activity AANAER_1335 ENOG4108RCM Nitroreductase AANAER_1339 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AANAER_1342 ENOG4105VEQ Cold shock protein AANAER_1343 ENOG4105QNF Outer membrane lipoprotein AANAER_1345 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AANAER_1348 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AANAER_1349 ENOG4105DWF phosphomethylpyrimidine kinase AANAER_1351 ENOG4105C5H ABC transporter AANAER_1353 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AANAER_1354 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AANAER_1355 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AANAER_1357 ENOG4105FGM Fructosamine kinase AANAER_1358 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_1360 ENOG4105C4M (Ubiquinol oxidase) subunit I AANAER_1363 ENOG4105C9Q fumarate hydratase class II AANAER_1365 ENOG4105BZU Histidine kinase AANAER_1366 ENOG4105CIN aminoacyl-histidine dipeptidase AANAER_1367 ENOG4107XWI flavin reductase domain protein, FMN-binding AANAER_1368 ENOG4105CZN Potassium uptake protein AANAER_1375 ENOG4105DJG MaoC domain protein dehydratase AANAER_1378 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region AANAER_1379 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AANAER_1380 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AANAER_1381 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AANAER_1382 ENOG4107QSN dihydrolipoamide acetyltransferase AANAER_1383 ENOG4107QN2 dihydrolipoyl dehydrogenase AANAER_1388 ENOG4105C87 Aminotransferase class I and II AANAER_1392 ENOG4105C5H ABC transporter AANAER_1394 ENOG4106TD9 Diguanylate cyclase AANAER_1396 ENOG4108RQS Two component transcriptional regulator (Winged helix family AANAER_1397 ENOG4105CRE cytochrome C AANAER_1398 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AANAER_1399 ENOG4105BZU Histidine kinase AANAER_1401 ENOG4105C5X domain protein AANAER_1402 ENOG4105ED9 Protein of unknown function (DUF455) AANAER_1403 ENOG4105FDP GntR family transcriptional regulator AANAER_1404 ENOG4105D5T phosphonate abc transporter AANAER_1410 ENOG4105FT8 Phosphonate metabolism AANAER_1411 ENOG4105ENV phosphonate C-P lyase system protein PhnK AANAER_1412 ENOG4105HRV phosphonate c-p lyase system protein phnl AANAER_1413 ENOG4105FD8 phosphonate metabolism protein PhnM AANAER_1415 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AANAER_1416 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AANAER_1417 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AANAER_1418 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AANAER_1421 ENOG4105BZU Histidine kinase AANAER_1424 ENOG4105BZU Histidine kinase AANAER_1425 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AANAER_1427 ENOG4105BZU Histidine kinase AANAER_1428 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1429 ENOG4108MRH transcriptional regulatory protein AANAER_1431 ENOG4108Z0R Transferase AANAER_1432 ENOG4105CDH Citrulline--aspartate ligase AANAER_1434 ENOG4107QYG anthranilate phosphoribosyltransferase AANAER_1435 ENOG4105K8N protein family UPF0079, ATPase AANAER_1436 ENOG4108IUZ ABC transporter AANAER_1437 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1438 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AANAER_1440 ENOG4105C2M dna polymerase I AANAER_1445 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AANAER_1446 ENOG4105DF6 Fe-S oxidoreductase AANAER_1447 ENOG4105D4P Coproporphyrinogen iii oxidase AANAER_1448 ENOG4105DBV ornithine carbamoyltransferase AANAER_1454 ENOG4107EFR Flavocytochrome c AANAER_1455 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1457 ENOG4105BZU Histidine kinase AANAER_1458 ENOG4105D52 delta-aminolevulinic acid dehydratase AANAER_1459 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AANAER_1460 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AANAER_1477 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AANAER_1497 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AANAER_1500 ENOG4108UUM single-stranded DNA-binding protein AANAER_1539 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AANAER_1540 ENOG4105D9Q decarboxylase (Beta subunit) AANAER_1541 ENOG4107QSA Oxaloacetate decarboxylase AANAER_1545 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AANAER_1547 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AANAER_1552 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AANAER_1554 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AANAER_1555 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AANAER_1557 ENOG4105EEI dihydropteroate synthase AANAER_1560 ENOG4105CFH Aspartokinase AANAER_1561 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AANAER_1562 ENOG4105CSA Coproporphyrinogen iii oxidase AANAER_1563 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AANAER_1564 ENOG4105DGW oligopeptidase A AANAER_1569 ENOG4105VN1 Heat shock protein AANAER_1570 ENOG4107Y70 Heat shock protein AANAER_1571 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AANAER_1572 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AANAER_1573 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AANAER_1574 ENOG4105BZU Histidine kinase AANAER_1575 ENOG4105CBS Chea signal transduction histidine kinase AANAER_1576 ENOG4108VYJ response regulator receiver protein AANAER_1577 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AANAER_1579 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AANAER_1581 ENOG4105C12 Phosphoribosylglycinamide synthetase AANAER_1583 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AANAER_1586 ENOG4105BZE flagellar hook protein, FlgE AANAER_1587 ENOG4105DTJ flagellar hook-associated protein AANAER_1588 ENOG4105BZE flagellar hook protein, FlgE AANAER_1591 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1592 ENOG4105CNU cell division protein FtsK AANAER_1593 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AANAER_1594 ENOG4108ZP8 Acetolactate synthase small subunit AANAER_1595 ENOG4105C7K acetolactate synthase AANAER_1599 ENOG4105BZU Histidine kinase AANAER_1600 ENOG4105CHH sulfate transporter AANAER_1606 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AANAER_1609 ENOG4105CTU Proline racemase AANAER_1611 ENOG4105CT1 (ABC) transporter AANAER_1612 ENOG4105MWK D-amino acid dehydrogenase, small subunit AANAER_1613 ENOG4105CTU Proline racemase AANAER_1614 ENOG4105CIF Ornithine Cyclodeaminase AANAER_1616 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AANAER_1620 ENOG4108ESY Metal dependent phosphohydrolase AANAER_1634 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AANAER_1635 ENOG4105CVM Molybdenum cofactor synthesis domain protein AANAER_1636 ENOG4105CGY Dna recombination protein AANAER_1637 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AANAER_1638 ENOG4105BZU Histidine kinase AANAER_1639 ENOG4107YD3 Thioesterase AANAER_1641 ENOG4105BZU Histidine kinase AANAER_1642 ENOG4108MUZ hydrolase AANAER_1643 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_1645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1646 ENOG4105CPC Aldo Keto reductase AANAER_1651 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AANAER_1653 ENOG4108K7V UPF0284 protein AANAER_1655 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AANAER_1657 ENOG4105EHG Permease protein AANAER_1658 ENOG4108JJB ABC transporter AANAER_1660 ENOG4105D05 Receptor AANAER_1665 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AANAER_1668 ENOG4105BZU Histidine kinase AANAER_1669 ENOG4105XJC Two component transcriptional regulator (Winged helix family AANAER_1672 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AANAER_1673 ENOG4105CIY formyltetrahydrofolate deformylase AANAER_1674 ENOG4105C6K Malic enzyme AANAER_1676 ENOG4105E2X shikimate dehydrogenase AANAER_1680 ENOG4105F5P DNA-damage-inducible protein d AANAER_1685 ENOG4105EYH Exonuclease AANAER_1688 ENOG4106032 Glutathionylspermidine synthase AANAER_1689 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AANAER_1690 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AANAER_1693 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AANAER_1695 ENOG41084AD Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AANAER_1696 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AANAER_1697 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AANAER_1699 ENOG4105C8J )-transporter AANAER_1700 ENOG4105C1J atp-dependent rna helicase AANAER_1711 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AANAER_1713 ENOG410841J DNA-binding protein Hu AANAER_1716 ENOG4105I03 Flagellin AANAER_1721 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1724 ENOG4105BZ1 (ABC) transporter AANAER_1730 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AANAER_1734 ENOG4105E9K Isocitrate dehydrogenase AANAER_1735 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AANAER_1737 ENOG4105C59 p-type ATPase AANAER_1740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AANAER_1743 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AANAER_1745 ENOG4105DVC DnaJ domain protein AANAER_1746 ENOG4105KNI merR family transcriptional Regulator AANAER_1747 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AANAER_1748 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AANAER_1750 ENOG4105C7H Helicase, RecD TraA family AANAER_1752 ENOG4105K89 arsenate reductase AANAER_1753 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AANAER_1755 ENOG4105D00 flagellar biosynthetic protein flhB AANAER_1757 ENOG4105CJN penicillin-binding protein AANAER_1758 ENOG4105CN7 Flagellar biosynthetic protein FliP AANAER_1761 ENOG4105ENT Efflux transporter rnd family, mfp subunit AANAER_1764 ENOG4105KY5 gCN5-related N-acetyltransferase AANAER_1765 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AANAER_1768 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AANAER_1769 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AANAER_1770 ENOG4105K6T rare lipoprotein A AANAER_1771 ENOG4105K4H Nlp p60 protein AANAER_1772 ENOG4105F8V Hydrolase, tatD family AANAER_1774 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AANAER_1775 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AANAER_1776 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AANAER_1780 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AANAER_1781 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AANAER_1782 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AANAER_1783 ENOG4105CUT histidyl-tRNA synthetase AANAER_1784 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AANAER_1785 ENOG4105D7W serine acetyltransferase AANAER_1788 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AANAER_1792 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related AANAER_1796 ENOG4108JPW Aminotransferase AANAER_1797 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) AANAER_1800 ENOG4105CFH Aspartokinase AANAER_1805 ENOG4105FCD Major Facilitator AANAER_1806 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AANAER_1808 ENOG4107QY8 reductase AANAER_1810 ENOG4105EB3 Histidine kinase AANAER_1812 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1813 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AANAER_1816 ENOG4105ND9 Nitrogenase-associated protein AANAER_1822 ENOG4105J9X quinohemoprotein amine dehydrogenase gamma subunit AANAER_1826 ENOG4105N14 lysine exporter protein LysE YggA AANAER_1832 ENOG4105PW4 Sugar fermentation stimulation protein homolog AANAER_1838 ENOG4107TIF Phenazine biosynthesis protein, PhzF family AANAER_1847 ENOG4107YUH hydrolase AANAER_1849 ENOG4105CQ7 ATP-dependent helicase AANAER_1863 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AANAER_1865 ENOG4108IYU L-aspartate oxidase AANAER_1869 ENOG41076HS cation diffusion facilitator family transporter AANAER_1871 ENOG4105C5H ABC transporter AANAER_1872 ENOG4105KTH gatB Yqey AANAER_1873 ENOG4106TD9 Diguanylate cyclase AANAER_1874 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AANAER_1875 ENOG4108I6A alcohol dehydrogenase AANAER_1876 ENOG4106HBX Transcriptional Regulator AraC Family AANAER_1877 ENOG4105BZU Histidine kinase AANAER_1886 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AANAER_1891 ENOG4105E1F short-chain dehydrogenase reductase AANAER_1892 ENOG4107S6Z Na H antiporter AANAER_1893 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AANAER_1894 ENOG4106H78 methyltransferase AANAER_1897 ENOG4105F4R Transcriptional regulator mode AANAER_1898 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) AANAER_1900 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AANAER_1901 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AANAER_1904 ENOG4105BZU Histidine kinase AANAER_1905 ENOG4105NQN cytochrome C AANAER_1906 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AANAER_1907 ENOG4105IPS esterase AANAER_1911 ENOG4105VEQ Cold shock protein AANAER_1913 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AANAER_1914 ENOG41080V7 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AANAER_1917 ENOG4108RAC Rubrerythrin AANAER_1919 ENOG4105CJR Integral membrane protein (MviN AANAER_1920 ENOG4105BZ1 (ABC) transporter AANAER_1921 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AANAER_1924 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AANAER_1925 ENOG4105CAN Short-chain dehydrogenase reductase Sdr AANAER_1926 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AANAER_1927 ENOG4105DZP Membrane-associated zinc metalloprotease AANAER_1928 ENOG4105DFA alanine racemase domain protein AANAER_1931 ENOG4105DK0 Indole-3-glycerol phosphate synthase AANAER_1933 ENOG4105QTX Pfam:UPF0153 AANAER_1934 ENOG41060K3 Methyltransferase AANAER_1936 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AANAER_1937 ENOG4105C7K acetolactate synthase AANAER_1940 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AANAER_1941 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AANAER_1942 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AANAER_1943 ENOG4105DJV ribulose-phosphate 3-epimerase AANAER_1944 ENOG4105HDD phospholipase AANAER_1945 ENOG4107VIJ nudix hydrolase AANAER_1947 ENOG4105BZU Histidine kinase AANAER_1948 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_1950 ENOG4108VPT UPF0234 protein AANAER_1951 ENOG4105C2W permease AANAER_1955 ENOG4105M08 Membrane AANAER_1957 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AANAER_1958 ENOG4105C7N Xanthine uracil vitamin C permease AANAER_1960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AANAER_1961 ENOG4105T16 Transcriptional regulator (AraC family) AANAER_1963 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AANAER_1964 ENOG41088CC tellurite resistance protein tehB AANAER_1966 ENOG4105QAX Iron-sulfur AANAER_1967 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AANAER_1973 ENOG4108MRH transcriptional regulatory protein AANAER_1974 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_1980 ENOG4105KPY Small multidrug resistance protein AANAER_1983 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AANAER_1990 ENOG4105C9U ATP-dependent DNA helicase RecQ AANAER_1992 ENOG4105D3R alkyl hydroperoxide reductase AANAER_1999 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AANAER_2003 ENOG4105DSF transport protein AANAER_2005 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AANAER_2008 ENOG4105CX6 glutaminyL-tRNA synthetase AANAER_2010 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AANAER_2016 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AANAER_2023 ENOG41082XB radical SAM domain protein AANAER_2024 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AANAER_2026 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AANAER_2029 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AANAER_2030 ENOG4107SVH Potassium channel protein AANAER_2031 ENOG4105VB9 50S ribosomal protein l28 AANAER_2034 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AANAER_2035 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AANAER_2036 ENOG4105K4U addiction module toxin, RelE StbE family AANAER_2039 ENOG4105D3Q Sugar transferase AANAER_2043 ENOG4107RJ7 Glycosyl transferase (Group 1 AANAER_2052 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AANAER_2055 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AANAER_2056 ENOG4105DKP glycosyl transferase, family 9 AANAER_2062 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AANAER_2066 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AANAER_2067 ENOG4106WTF Glycosyl transferase, family 2 AANAER_2068 ENOG4108KMV Glycosyl transferase (Group 1 AANAER_2070 ENOG4107QQG Dehydrogenase AANAER_2075 ENOG41080IJ Diacylglycerol kinase AANAER_2077 ENOG4105DKP glycosyl transferase, family 9 AANAER_2080 ENOG4105BZ8 glutamate synthase AANAER_2081 ENOG4105CBC glutamate synthase AANAER_2082 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AANAER_2083 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AANAER_2085 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AANAER_2086 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) AANAER_2087 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) AANAER_2089 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AANAER_2090 ENOG4105BZU Histidine kinase AANAER_2091 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AANAER_2093 ENOG4105CJZ response regulator AANAER_2094 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AANAER_2096 ENOG410812K response regulator receiver protein AANAER_2100 ENOG4105BZU Histidine kinase AANAER_2105 ENOG4105C32 Amino acid ABC transporter (Permease) AANAER_2106 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AANAER_2107 ENOG4105C0Z ABC transporter AANAER_2108 ENOG4108IV0 ABC, transporter AANAER_2109 ENOG4105C26 Dehydrogenase AANAER_2111 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_2112 ENOG4105BZU Histidine kinase AANAER_2113 ENOG4108HGU Histidine kinase AANAER_2114 ENOG4105BZU Histidine kinase AANAER_2119 ENOG4105CF7 AraC family transcriptional regulator AANAER_2120 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AANAER_2122 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AANAER_2123 ENOG4105C87 Aminotransferase class I and II AANAER_2125 ENOG4105DEN Luciferase family AANAER_2126 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AANAER_2129 ENOG4105ENX hydrolase AANAER_2130 ENOG4105DQ4 alcohol dehydrogenase AANAER_2132 ENOG4107QW4 alcohol dehydrogenase AANAER_2133 ENOG4107RTG Major Facilitator superfamily AANAER_2141 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AANAER_2142 ENOG4105M7K Involved in the transcription termination process (By similarity) AANAER_2143 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AANAER_2144 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AANAER_2148 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AANAER_2152 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AANAER_2153 ENOG4105DX0 Hemolysin A AANAER_2154 ENOG4105DTN riboflavin biosynthesis protein ribF AANAER_2155 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AANAER_2156 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AANAER_2158 ENOG4105CQB FAD linked oxidase domain protein AANAER_2159 ENOG4107S2Z UPF0761 membrane protein AANAER_2163 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AANAER_2164 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AANAER_2165 ENOG4108BGM Quinol dehydrogenase periplasmic component AANAER_2166 ENOG4105GXZ Ferredoxin-type protein NapH AANAER_2167 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) AANAER_2168 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2172 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AANAER_2175 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AANAER_2185 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AANAER_2188 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AANAER_2189 ENOG4108DBC nitroreductase AANAER_2190 ENOG4105C26 Dehydrogenase AANAER_2191 ENOG4108V06 Glutathione peroxidase AANAER_2193 ENOG4108RCM Nitroreductase AANAER_2195 ENOG4105NF4 modulator of drug activity AANAER_2196 ENOG4107QW4 alcohol dehydrogenase AANAER_2197 ENOG4105KVH Transcriptional regulator AANAER_2198 ENOG4105DXB Major Facilitator superfamily AANAER_2199 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AANAER_2200 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AANAER_2201 ENOG4108YZY peptidylprolyl cis-trans isomerase AANAER_2205 ENOG4105DY9 regulatoR AANAER_2206 ENOG4108HRK Histidine kinase AANAER_2208 ENOG4105CVP deoxyribo-dipyrimidine photolyase AANAER_2210 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AANAER_2212 ENOG4105M8F Biopolymer transport protein exbD tolR AANAER_2213 ENOG4105E02 MotA TolQ exbB proton channel AANAER_2214 ENOG41082MC Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AANAER_2215 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AANAER_2216 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AANAER_2217 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AANAER_2218 ENOG4105PQH F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AANAER_2219 ENOG4105YF2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AANAER_2221 ENOG4105FA0 parb-like partition protein AANAER_2222 ENOG4107QJE Chromosome Partitioning Protein AANAER_2225 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AANAER_2226 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AANAER_2227 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AANAER_2228 ENOG4105K46 50S ribosomal protein l27 AANAER_2229 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AANAER_2231 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AANAER_2233 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AANAER_2234 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AANAER_2235 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AANAER_2238 ENOG4107RNH Outer membrane receptor FepA AANAER_2241 ENOG4105S10 periplasmic binding protein AANAER_2242 ENOG4105EHG Permease protein AANAER_2243 ENOG4108W0P ABC transporter AANAER_2245 ENOG4105X58 receptor AANAER_2247 ENOG4105EHG Permease protein AANAER_2248 ENOG4108IPW abc transporter atp-binding protein AANAER_2252 ENOG4105VYW UPF0251 protein AANAER_2253 ENOG4105D0M Protease HtpX homolog AANAER_2255 ENOG4105EEX Two component transcriptional regulator (Winged helix family AANAER_2256 ENOG4105CVJ phosphoglycerate mutase AANAER_2258 ENOG4105CBX hi0933 family AANAER_2260 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AANAER_2262 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AANAER_2263 ENOG4108512 Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AANAER_2264 ENOG41067YR RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AANAER_2266 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AANAER_2269 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AANAER_2277 ENOG4105EHG Permease protein AANAER_2278 ENOG4105E0A ABC, transporter AANAER_2280 ENOG4108HUF Transporter AANAER_2282 ENOG4105GAV receptor AANAER_2285 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AANAER_2286 ENOG4105M8K biopolymer transport protein AANAER_2287 ENOG4105M15 transport protein ExbD AANAER_2289 ENOG4105E0X reductase AANAER_2290 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AANAER_2293 ENOG4105BZU Histidine kinase AANAER_2294 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AANAER_2299 ENOG4108Z5K methylglyoxal synthase AANAER_2303 ENOG4105DC1 bifunctional purine biosynthesis protein purh AANAER_2313 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AANAER_2318 ENOG4105D7Z glutathione synthase AANAER_2319 ENOG4107QIK phosphoribosylformylglycinamidine synthase AANAER_2321 ENOG4105E4C Lytic transglycosylase catalytic AANAER_2322 ENOG4105CJW magnesium transporter AANAER_2323 ENOG410829K Lysine exporter protein (Lyse ygga) AANAER_2324 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_2325 ENOG4105EUJ GTP cyclohydrolase i AANAER_2327 ENOG4107QHF type ii secretion system protein e AANAER_2330 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AANAER_2331 ENOG4105C0P Mg chelatase subunit ChlI AANAER_2332 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AANAER_2333 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AANAER_2334 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AANAER_2336 ENOG4105CSR polyphosphate kinase 2 AANAER_2337 ENOG4105CSR polyphosphate kinase 2 AANAER_2342 ENOG4105DFP Integrase AANAER_2344 ENOG4105D5G Transposase AANAER_2347 ENOG4107QP8 phosphohexose isomerase AANAER_2348 ENOG4108UHU Aldolase AANAER_2349 ENOG4105C01 Dihydroxy-acid dehydratase AANAER_2351 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AANAER_2354 ENOG4105C3Q Glycosyl transferase, family 2 AANAER_2355 ENOG4105D1Z hydroxypyruvate reductase AANAER_2356 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase AANAER_2358 ENOG4105BZU Histidine kinase AANAER_2359 ENOG4105CA0 peroxidase AANAER_2362 ENOG4105CE1 Ferrous iron transport protein b AANAER_2364 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AANAER_2365 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AANAER_2366 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AANAER_2367 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AANAER_2368 ENOG4105F4G Membrane AANAER_2371 ENOG4105F1S paraquat-inducible protein a AANAER_2372 ENOG4105DY2 Paraquat-inducible protein b AANAER_2374 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AANAER_2375 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AANAER_2376 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AANAER_2381 ENOG4105D7B Flagellar biosynthesis protein flha AANAER_2382 ENOG4108JIR Flagellum-specific ATP synthase AANAER_2384 ENOG4105D00 flagellar biosynthetic protein flhB AANAER_2387 ENOG4108ZC9 flagellar basal-body rod protein flgc AANAER_2388 ENOG41084DA flagellar hook-basal body complex protein fliE AANAER_2390 ENOG4107R21 site-determining protein AANAER_2391 ENOG4105FZW flagellar biosynthesis regulator FlhF AANAER_2394 ENOG4105YKR AANAER_2396 ENOG4105E14 MotA TolQ exbB proton channel AANAER_2397 ENOG4105DD5 Flagellar motor switch protein AANAER_2401 ENOG4105DD5 Flagellar motor switch protein AANAER_2403 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AANAER_2404 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AANAER_2405 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AANAER_2406 ENOG4105CGA flagellar basal-body rod protein FlgG AANAER_2408 ENOG4108VYJ response regulator receiver protein AANAER_2409 ENOG4105CGA flagellar basal-body rod protein FlgG AANAER_2412 ENOG4105V3S An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AANAER_2413 ENOG4105VB6 UPF0109 protein AANAER_2414 ENOG4105K5M 30s ribosomal protein S16 AANAER_2415 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AANAER_2416 ENOG4105EI2 Pseudouridine synthase AANAER_2417 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AANAER_2419 ENOG4105EGD dinuclear metal center protein, YbgI family AANAER_2420 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit AANAER_2422 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AANAER_2424 ENOG4105CFP Peptidase U32 AANAER_2425 ENOG41080BE Methyl-accepting chemotaxis sensory transducer AANAER_2425 ENOG41080BE Methyl-accepting chemotaxis sensory transducer AANAER_2426 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AANAER_2427 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AANAER_2429 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AANAER_2430 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AANAER_2431 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AANAER_2435 ENOG4108UPT UPF0178 protein AANAER_2439 ENOG4105S10 periplasmic binding protein AANAER_2440 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) AANAER_2441 ENOG4105E0A ABC, transporter AANAER_2443 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_2444 ENOG4105BZU Histidine kinase AANAER_2446 ENOG4105F27 Major Facilitator AANAER_2454 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AANAER_2456 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AANAER_2485 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AANAER_2486 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AANAER_2487 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AANAER_2488 ENOG4108VZM 50s ribosomal protein L10 AANAER_2489 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AANAER_2490 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AANAER_2491 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AANAER_2494 ENOG41086AR 50S ribosomal protein L33 AANAER_2495 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AANAER_2500 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AANAER_2501 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AANAER_2502 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AANAER_2504 ENOG4108JQC penicillin-binding protein 1A AANAER_2505 ENOG4105C5F glutamine synthetase AANAER_2506 ENOG4107RVV histidinol phosphate phosphatase, hisj family AANAER_2507 ENOG4105BZU Histidine kinase AANAER_2508 ENOG4108ZEX molybdopterin converting factor, subunit 2 AANAER_2510 ENOG4108XUR Pfam:DUF178 AANAER_2511 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AANAER_2513 ENOG4105CNI cell division protein FtsW AANAER_2514 ENOG4105CJN penicillin-binding protein AANAER_2515 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AANAER_2525 ENOG4105DDQ anthranilate synthase AANAER_2526 ENOG4105BZU Histidine kinase AANAER_2527 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AANAER_2528 ENOG4105C87 Aminotransferase class I and II AANAER_2529 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AANAER_2530 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2531 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2534 ENOG4105BZN citrate synthase AANAER_2536 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AANAER_2538 ENOG4107UFS subunit j AANAER_2539 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2540 ENOG4105D65 subunit l AANAER_2541 ENOG4105C8S subunit m AANAER_2542 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2543 ENOG4108S24 Fumarate reduCtase AANAER_2544 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AANAER_2545 ENOG4105E33 succinate dehydrogenase AANAER_2546 ENOG410890F Dynamin family AANAER_2548 ENOG4105C7K acetolactate synthase AANAER_2549 ENOG4105C26 Dehydrogenase AANAER_2551 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AANAER_2560 ENOG41081FY multiple antibiotic resistance (MarC)-related AANAER_2561 ENOG4105EAD ABC transporter AANAER_2562 ENOG4106PMH Extracellular solute-binding protein family 3 AANAER_2563 ENOG4106PMH Extracellular solute-binding protein family 3 AANAER_2568 ENOG4105C09 Bile acid AANAER_2570 ENOG4105N14 lysine exporter protein LysE YggA AANAER_2572 ENOG4105CR4 methylisocitrate lyase AANAER_2573 ENOG4105BZN citrate synthase AANAER_2574 ENOG4108I0Z Aconitate hydratase AANAER_2575 ENOG4105C7F AcnD-accessory protein PrpF AANAER_2577 ENOG4105BZU Histidine kinase AANAER_2579 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AANAER_2581 ENOG4107QMP dna polymerase iii subunits gamma and tau AANAER_2582 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AANAER_2584 ENOG4105D01 (LipO)protein AANAER_2585 ENOG4108UMI ABC transporter, permease AANAER_2586 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AANAER_2589 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AANAER_2590 ENOG4105D3R alkyl hydroperoxide reductase AANAER_2592 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AANAER_2594 ENOG4105YQ2 50s ribosomal protein l32 AANAER_2595 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AANAER_2596 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AANAER_2598 ENOG4108UMN azlc family AANAER_2607 ENOG4105CXT aspartate transcarbamylase AANAER_2608 ENOG4105C8Y Acetylornithine aminotransferase AANAER_2611 ENOG4108ZG0 Ompa motb domain protein AANAER_2614 ENOG4105C26 Dehydrogenase AANAER_2615 ENOG4105BZU Histidine kinase AANAER_2616 ENOG4105XJC Two component transcriptional regulator (Winged helix family AANAER_2618 ENOG4108IEG Formate dehydrogenase Alpha subunit AANAER_2619 ENOG41082UM UPF0102 protein AANAER_2620 ENOG4107R4J Chloride channel AANAER_2622 ENOG4105CKD glutathione-regulated potassium-efflux system protein AANAER_2623 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AANAER_2627 ENOG4105DVY radical SAM domain protein AANAER_2632 ENOG4105KB8 (LipO)protein AANAER_2633 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AANAER_2635 ENOG4105CHV Transcription elongation factor NusA AANAER_2636 ENOG4105C8N cysteinyl-tRNA synthetase AANAER_2638 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AANAER_2639 ENOG4105F38 ABC transporter, permease AANAER_2640 ENOG4107QKW extracellular solute-binding protein family 1 AANAER_2641 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AANAER_2642 ENOG4108UUM single-stranded DNA-binding protein AANAER_2643 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AANAER_2644 ENOG4108VMB DNA polymerase III subunit delta' AANAER_2646 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AANAER_2647 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AANAER_2649 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AANAER_2650 ENOG4105C79 DNA protecting protein DprA AANAER_2651 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AANAER_2652 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_2653 ENOG4105DFU Cell wall formation (By similarity) AANAER_2655 ENOG4105CHM Aminotransferase AANAER_2657 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AANAER_2658 ENOG410855J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AANAER_2659 ENOG4105KUZ arsenate reductase AANAER_2660 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase AANAER_2661 ENOG4107V25 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AANAER_2662 ENOG4105EAC phosphoserine phosphatase AANAER_2663 ENOG4105GSH Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AANAER_2664 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AANAER_2666 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AANAER_2667 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AANAER_2671 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AANAER_2676 ENOG4105VS8 Flagellar biosynthetic protein fliq AANAER_2678 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AANAER_2679 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AANAER_2681 ENOG4108YZA Nitrogen regulatory protein pii AANAER_2683 ENOG4108YZA Nitrogen regulatory protein pii AANAER_2687 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AANAER_2688 ENOG4105FR1 rard protein AANAER_2692 ENOG4107R5R arsenical pump membrane protein AANAER_2694 ENOG41085FC arsR family transcriptional regulator AANAER_2695 ENOG4105CV1 Transketolase (EC 2.2.1.1) AANAER_2698 ENOG4107QZV Type I secretion membrane fusion protein AANAER_2701 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_2702 ENOG4105BZU Histidine kinase AANAER_2706 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit AANAER_2707 ENOG4107QIZ NADH dehydrogenase AANAER_2708 ENOG4107QHI -hydrogenase AANAER_2712 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AANAER_2713 ENOG4107RFW hydrolase family 57 AANAER_2715 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AANAER_2717 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AANAER_2721 ENOG4105CTQ phosphohexokinase AANAER_2723 ENOG4105C6W 4-alpha-glucanotransferase (EC 2.4.1.25) AANAER_2725 ENOG4105CHB tonB-dependent Receptor AANAER_2729 ENOG4105EEX Two component transcriptional regulator (Winged helix family AANAER_2731 ENOG4105CJZ response regulator AANAER_2732 ENOG4105BZU Histidine kinase AANAER_2733 ENOG4105BZU Histidine kinase AANAER_2735 ENOG4105C8Q Methyl-accepting chemotaxis AANAER_2739 ENOG4105C01 Dihydroxy-acid dehydratase AANAER_2747 ENOG4105C0H protease AANAER_2748 ENOG4105E3W Two component transcriptional regulator (Winged helix family AANAER_2749 ENOG4107ZY3 Histidine kinase AANAER_2751 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AANAER_2754 ENOG41081FY multiple antibiotic resistance (MarC)-related AANAER_2755 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AANAER_2759 ENOG4105BZU Histidine kinase AANAER_2760 ENOG4105DJ4 phosphatidylserine decarboxylase AANAER_2764 ENOG4105CFG Acts as a chaperone (By similarity) AANAER_2765 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AANAER_2768 ENOG4105XJC Two component transcriptional regulator (Winged helix family AANAER_2769 ENOG4105BZU Histidine kinase AANAER_2770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AANAER_2772 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AANAER_2773 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AANAER_2774 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AANAER_2775 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AANAER_2777 ENOG4105CB5 ATP-dependent DNA helicase recG AANAER_2778 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AANAER_2779 ENOG4105I03 Flagellin AANAER_2785 ENOG4105C7K acetolactate synthase AANAER_2789 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AANAER_2790 ENOG4105C6Y Udp-glucose 6-dehydrogenase AANAER_2792 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AANAER_2793 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AANAER_2795 ENOG4105D2T synthase AANAER_2796 ENOG4105F0R Cytidylyltransferase AANAER_2797 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AANAER_2798 ENOG4105C5E polysaccharide biosynthesis protein AANAER_2800 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AANAER_2801 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AANAER_2805 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AANAER_2808 ENOG4105D4A Cell wall formation (By similarity) AANAER_2809 ENOG4105E63 Pfam:DUF178 AANAER_2810 ENOG4107MMM Anti-sigma-factor antagonist AANAER_2815 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2816 ENOG4105C8S subunit m AANAER_2817 ENOG4105D65 subunit l AANAER_2818 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2820 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2821 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AANAER_2825 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2826 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AANAER_2827 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AANAER_2828 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AANAER_2838 ENOG4105D5G Transposase AANAER_2839 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AANAER_2842 ENOG4105WPN DNA integration recombination invertion protein AANAER_2843 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AANAER_2844 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AANAER_2845 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AANAER_2846 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AANAER_2847 ENOG4105DFF Rod shape-determining protein mreb AANAER_2849 ENOG4108J5H Homocysteine s-methyltransferase AANAER_2851 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AANAER_2868 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_2869 ENOG4105BZU Histidine kinase AANAER_2870 ENOG4105D5G Transposase AANAER_2872 ENOG4105DIJ Phosphoethanolamine transferase AANAER_2874 ENOG4105C58 cytochrome c oxidase accessory protein ccog AANAER_2875 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AANAER_2876 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AANAER_2879 ENOG4107S0N DJ-1 family AANAER_2883 ENOG4105C0B DNA polymerase III (alpha subunit) AANAER_2884 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AANAER_2889 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AANAER_2890 ENOG41082DJ 30S ribosomal protein S21 AANAER_2902 ENOG4105HFZ Membrane AANAER_2903 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AANAER_2904 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AANAER_2905 ENOG4105NU9 Preprotein translocase subunit SecG AANAER_2907 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AANAER_2908 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AANAER_2910 ENOG4105D8G Major Facilitator superfamily AANAER_2912 ENOG410802Z Protein of unknown function (DUF328) AANAER_2914 ENOG4105K5B UPF0225 protein AANAER_2915 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AANAER_2918 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AANAER_2919 ENOG4108V0P LemA family AANAER_2920 ENOG4105HA9 of methanol dehydrogenase type AANAER_2922 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AANAER_2930 ENOG4105CBX hi0933 family AANAER_2941 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AANAER_2942 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AANAER_2943 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AANAER_2944 ENOG4105C9B Cysteine desulfurase AANAER_2945 ENOG4105DIN metallophosphoesterase AANAER_2956 ENOG4105CI3 gtp-binding protein typa AANAER_2957 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AANAER_2958 ENOG4107XPZ Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AANAER_2963 ENOG4107RN3 metallophosphoesterase AANAER_2973 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AANAER_2975 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AANAER_2976 ENOG4105EN6 Membrane AANAER_2977 ENOG4107QN2 dihydrolipoyl dehydrogenase AANAER_2978 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AANAER_2979 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AANAER_2980 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AANAER_2981 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AANAER_2982 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AANAER_2983 ENOG4105D3R alkyl hydroperoxide reductase AANAER_2986 ENOG4105BZU Histidine kinase AANAER_2987 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AANAER_2989 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)