locus-tag	class	description
AAQM_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AAQM_0002	COG0592	DNA-directed DNA polymerase activity
AAQM_0003	COG0187	DNA topoisomerase II activity
AAQM_0004	COG0492	ferredoxin-NADP+ reductase activity
AAQM_0005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AAQM_0008	COG1238	metal cluster binding
AAQM_0010	COG0564	pseudouridine synthase activity
AAQM_0011	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AAQM_0012	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAQM_0013	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAQM_0019	COG2954	triphosphatase activity
AAQM_0020	COG1151	hydroxylamine reductase activity
AAQM_0022	COG0493	'glutamate synthase
AAQM_0023	COG3047	cAMP biosynthetic process
AAQM_0023	COG2885	chlorophyll binding
AAQM_0024	COG0052	Belongs to the universal ribosomal protein uS2 family
AAQM_0025	COG0604	alcohol dehydrogenase
AAQM_0027	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AAQM_0028	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AAQM_0031	COG0745	RESPONSE REGULATOR receiver
AAQM_0032	COG4191	Histidine kinase
AAQM_0033	COG1556	Lactate utilization protein
AAQM_0034	COG1139	Iron-sulfur cluster binding protein
AAQM_0035	COG0247	lactate metabolic process
AAQM_0037	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAQM_0037	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAQM_0038	COG0511	ligase activity, forming carbon-carbon bonds
AAQM_0039	COG0439	Biotin carboxylase
AAQM_0040	COG0513	Belongs to the DEAD box helicase family
AAQM_0041	COG0306	phosphate transporter
AAQM_0043	COG0367	asparagine synthase
AAQM_0045	COG0778	Nitroreductase
AAQM_0047	COG1053	succinate dehydrogenase
AAQM_0049	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AAQM_0051	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AAQM_0051	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AAQM_0052	COG1187	pseudouridine synthase activity
AAQM_0053	COG0517	IMP dehydrogenase activity
AAQM_0053	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AAQM_0055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AAQM_0056	COG0107	imidazoleglycerol-phosphate synthase activity
AAQM_0059	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AAQM_0060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AAQM_0061	COG0724	RNA recognition motif
AAQM_0062	COG0745	RESPONSE REGULATOR receiver
AAQM_0063	COG0642	Histidine kinase
AAQM_0067	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AAQM_0068	COG2353	YceI-like domain
AAQM_0070	COG0534	Mate efflux family protein
AAQM_0071	COG0460	homoserine dehydrogenase
AAQM_0072	COG0436	Aminotransferase
AAQM_0075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AAQM_0076	COG0254	rRNA binding
AAQM_0077	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AAQM_0083	COG0582	viral genome integration into host DNA
AAQM_0099	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AAQM_0101	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AAQM_0102	COG0237	dephospho-CoA kinase activity
AAQM_0103	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AAQM_0104	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AAQM_0105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AAQM_0106	COG1741	Belongs to the pirin family
AAQM_0107	COG3384	dioxygenase
AAQM_0109	COG1846	Transcriptional regulator
AAQM_0110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AAQM_0111	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AAQM_0112	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AAQM_0114	COG0505	Belongs to the CarA family
AAQM_0118	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AAQM_0118	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AAQM_0121	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AAQM_0122	COG0489	protein tyrosine kinase activity
AAQM_0124	COG0140	phosphoribosyl-ATP diphosphatase activity
AAQM_0124	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AAQM_0129	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AAQM_0131	COG0646	methionine synthase
AAQM_0131	COG1410	methionine synthase
AAQM_0132	COG0450	alkyl hydroperoxide reductase
AAQM_0135	COG1979	alcohol dehydrogenase
AAQM_0136	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAQM_0136	COG2205	protein histidine kinase activity
AAQM_0138	COG1686	Belongs to the peptidase S11 family
AAQM_0141	COG1854	S-ribosylhomocysteine lyase activity
AAQM_0146	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AAQM_0147	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AAQM_0150	COG3180	Ammonia monooxygenase
AAQM_0151	COG1733	regulation of RNA biosynthetic process
AAQM_0152	COG2249	NAD(P)H dehydrogenase (quinone) activity
AAQM_0153	COG1013	pyruvate-flavodoxin oxidoreductase activity
AAQM_0154	COG0674	pyruvate-flavodoxin oxidoreductase activity
AAQM_0156	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AAQM_0157	COG0546	phosphoglycolate phosphatase activity
AAQM_0159	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AAQM_0160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AAQM_0161	COG2205	protein histidine kinase activity
AAQM_0162	COG0745	RESPONSE REGULATOR receiver
AAQM_0164	COG0704	Plays a role in the regulation of phosphate uptake
AAQM_0165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AAQM_0166	COG0581	inorganic phosphate transmembrane transporter activity
AAQM_0167	COG0573	inorganic phosphate transmembrane transporter activity
AAQM_0168	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AAQM_0170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AAQM_0171	COG0268	Binds directly to 16S ribosomal RNA
AAQM_0172	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AAQM_0173	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AAQM_0174	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AAQM_0175	COG0746	molybdenum cofactor guanylyltransferase activity
AAQM_0176	COG0446	pyridine nucleotide-disulphide oxidoreductase
AAQM_0179	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AAQM_0180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AAQM_0181	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AAQM_0189	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AAQM_0193	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_0193	COG4221	oxidoreductase activity
AAQM_0193	COG3321	synthase
AAQM_0193	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AAQM_0194	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAQM_0196	COG1131	(ABC) transporter
AAQM_0201	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_0202	COG2986	histidine ammonia-lyase
AAQM_0207	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAQM_0208	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AAQM_0213	COG0575	Belongs to the CDS family
AAQM_0214	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AAQM_0218	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AAQM_0220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AAQM_0220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AAQM_0221	COG1324	tolerance protein
AAQM_0222	COG2022	thiamine diphosphate biosynthetic process
AAQM_0230	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AAQM_0231	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAQM_0235	COG0840	transmembrane signaling receptor activity
AAQM_0239	COG0745	RESPONSE REGULATOR receiver
AAQM_0244	COG4191	Histidine kinase
AAQM_0245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AAQM_0249	COG1346	cytolysis
AAQM_0255	COG0659	secondary active sulfate transmembrane transporter activity
AAQM_0258	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AAQM_0260	COG3290	protein histidine kinase activity
AAQM_0263	COG0004	ammonium transporteR
AAQM_0264	COG0347	Belongs to the P(II) protein family
AAQM_0265	COG0004	ammonium transporteR
AAQM_0267	COG0418	dihydroorotase activity
AAQM_0269	COG1706	bacterial-type flagellum-dependent cell motility
AAQM_0276	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AAQM_0277	COG1256	bacterial-type flagellum assembly
AAQM_0277	COG4786	Flagellar basal body rod
AAQM_0278	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AAQM_0282	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AAQM_0283	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AAQM_0284	COG0601	transmembrane transport
AAQM_0285	COG0736	holo-[acyl-carrier-protein] synthase activity
AAQM_0286	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AAQM_0288	COG0560	Phosphoserine phosphatase
AAQM_0289	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AAQM_0290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AAQM_0291	COG3248	Nucleoside-binding outer membrane protein
AAQM_0292	COG1393	Belongs to the ArsC family
AAQM_0293	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AAQM_0294	COG0343	queuine tRNA-ribosyltransferase activity
AAQM_0296	COG0436	Aminotransferase
AAQM_0300	COG2861	carbohydrate metabolic process
AAQM_0301	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AAQM_0302	COG0557	exoribonuclease II activity
AAQM_0303	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AAQM_0305	COG0360	Binds together with S18 to 16S ribosomal RNA
AAQM_0306	COG0629	single-stranded DNA binding
AAQM_0307	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AAQM_0309	COG0215	cysteine-tRNA ligase activity
AAQM_0310	COG0195	Participates in both transcription termination and antitermination
AAQM_0312	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AAQM_0313	COG2121	Domain of unknown function (DUF374)
AAQM_0315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AAQM_0317	COG0288	reversible hydration of carbon dioxide
AAQM_0318	COG0156	8-amino-7-oxononanoate synthase activity
AAQM_0319	COG0792	nuclease activity
AAQM_0322	COG2885	chlorophyll binding
AAQM_0323	COG0469	pyruvate kinase activity
AAQM_0325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AAQM_0327	COG0540	Belongs to the ATCase OTCase family
AAQM_0328	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AAQM_0329	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AAQM_0332	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AAQM_0333	COG1687	branched-chain amino acid
AAQM_0334	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AAQM_0335	COG0416	fatty acid biosynthetic process
AAQM_0336	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AAQM_0338	COG0105	UTP biosynthetic process
AAQM_0340	COG0450	alkyl hydroperoxide reductase
AAQM_0341	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AAQM_0342	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AAQM_0343	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AAQM_0344	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AAQM_0346	COG0181	hydroxymethylbilane synthase activity
AAQM_0349	COG2828	Protein conserved in bacteria
AAQM_0350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AAQM_0352	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AAQM_0354	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AAQM_0359	COG0514	ATP-dependent DNA helicase (RecQ)
AAQM_0360	COG0500	methyltransferase
AAQM_0363	COG1451	nucleotide metabolic process
AAQM_0368	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AAQM_0369	COG1053	succinate dehydrogenase
AAQM_0371	COG1007	ATP synthesis coupled electron transport
AAQM_0373	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AAQM_0374	COG0713	ATP synthesis coupled electron transport
AAQM_0375	COG0839	Belongs to the complex I subunit 6 family
AAQM_0376	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_0377	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AAQM_0378	COG1034	ATP synthesis coupled electron transport
AAQM_0379	COG0372	Belongs to the citrate synthase family
AAQM_0382	COG0649	NAD binding
AAQM_0382	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_0383	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_0384	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_0385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AAQM_0386	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AAQM_0387	COG3610	response to peptide
AAQM_0388	COG2966	Psort location CytoplasmicMembrane, score
AAQM_0390	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AAQM_0391	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AAQM_0393	COG0840	transmembrane signaling receptor activity
AAQM_0398	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AAQM_0401	COG0840	transmembrane signaling receptor activity
AAQM_0405	COG3043	anaerobic respiration
AAQM_0406	COG0348	domain, Protein
AAQM_0407	COG0437	4 iron, 4 sulfur cluster binding
AAQM_0408	COG0243	molybdopterin cofactor binding
AAQM_0413	COG2204	response regulator
AAQM_0414	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AAQM_0415	COG1648	precorrin-2 dehydrogenase activity
AAQM_0415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AAQM_0418	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AAQM_0419	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AAQM_0422	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AAQM_0423	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AAQM_0424	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AAQM_0425	COG1959	2 iron, 2 sulfur cluster binding
AAQM_0426	COG2404	hydrolase activity, acting on ester bonds
AAQM_0428	COG0642	Histidine kinase
AAQM_0429	COG0745	RESPONSE REGULATOR receiver
AAQM_0431	COG0191	fructose-bisphosphate aldolase activity
AAQM_0432	COG3842	ATPase activity
AAQM_0434	COG1177	transmembrane transport
AAQM_0435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AAQM_0440	COG1278	Cold shock
AAQM_0442	COG0811	peptide transport
AAQM_0444	COG4191	Histidine kinase
AAQM_0447	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AAQM_0449	COG0142	geranyltranstransferase activity
AAQM_0450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AAQM_0451	COG0442	prolyl-tRNA aminoacylation
AAQM_0452	COG0668	transmembrane transport
AAQM_0453	COG0617	tRNA 3'-terminal CCA addition
AAQM_0456	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AAQM_0457	COG1862	Preprotein translocase
AAQM_0458	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AAQM_0459	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AAQM_0461	COG0495	leucyl-tRNA aminoacylation
AAQM_0463	COG0285	dihydrofolate synthase activity
AAQM_0471	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AAQM_0473	COG2203	Gaf domain
AAQM_0473	COG5001	Diguanylate cyclase
AAQM_0473	COG3706	GGDEF domain
AAQM_0473	COG4251	negative regulation of phosphorylation
AAQM_0475	COG0745	RESPONSE REGULATOR receiver
AAQM_0476	COG0642	Histidine kinase
AAQM_0477	COG2081	HI0933 family
AAQM_0478	COG0840	transmembrane signaling receptor activity
AAQM_0480	COG3920	Histidine kinase
AAQM_0481	COG5000	phosphorelay sensor kinase activity
AAQM_0482	COG1692	metallophosphoesterase
AAQM_0485	COG2226	methyltransferase
AAQM_0486	COG1570	exodeoxyribonuclease VII activity
AAQM_0487	COG0835	chemotaxis
AAQM_0489	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AAQM_0491	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AAQM_0492	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AAQM_0495	COG0459	protein refolding
AAQM_0496	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AAQM_0499	COG1408	metallophosphoesterase
AAQM_0504	COG1136	(ABC) transporter
AAQM_0504	COG0577	efflux transmembrane transporter activity
AAQM_0505	COG1136	(ABC) transporter
AAQM_0505	COG0577	efflux transmembrane transporter activity
AAQM_0507	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AAQM_0510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AAQM_0511	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AAQM_0512	COG0352	thiamine-phosphate diphosphorylase activity
AAQM_0513	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AAQM_0515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AAQM_0516	COG2264	protein methyltransferase activity
AAQM_0517	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AAQM_0518	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAQM_0521	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AAQM_0522	COG3706	GGDEF domain
AAQM_0523	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AAQM_0524	COG1090	epimerase
AAQM_0525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AAQM_0528	COG0481	GTPase activity
AAQM_0531	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AAQM_0533	COG0482	sulfurtransferase activity
AAQM_0534	COG0482	sulfurtransferase activity
AAQM_0535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AAQM_0536	COG0006	proline dipeptidase activity
AAQM_0537	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AAQM_0538	COG0402	S-adenosylhomocysteine deaminase activity
AAQM_0539	COG0616	signal peptide processing
AAQM_0541	COG0280	phosphate acetyltransferase
AAQM_0542	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AAQM_0544	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AAQM_0548	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AAQM_0550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AAQM_0552	COG0745	RESPONSE REGULATOR receiver
AAQM_0553	COG5002	protein histidine kinase activity
AAQM_0562	COG1546	Belongs to the CinA family
AAQM_0562	COG1058	Belongs to the CinA family
AAQM_0563	COG0579	oxidoreductase
AAQM_0564	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AAQM_0568	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AAQM_0573	COG0714	Associated with various cellular activities
AAQM_0574	COG0052	Belongs to the universal ribosomal protein uS2 family
AAQM_0575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AAQM_0576	COG1136	(ABC) transporter
AAQM_0578	COG0194	GDP metabolic process
AAQM_0579	COG5002	protein histidine kinase activity
AAQM_0579	COG5001	Diguanylate cyclase
AAQM_0580	COG2217	Heavy metal translocating P-type atpase
AAQM_0583	COG4608	Belongs to the ABC transporter superfamily
AAQM_0584	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AAQM_0585	COG2078	PFAM AMMECR1 domain protein
AAQM_0586	COG1355	regulation of microtubule-based process
AAQM_0587	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AAQM_0588	COG1121	(ABC) transporter
AAQM_0589	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AAQM_0590	COG1283	sodium-dependent phosphate transmembrane transporter activity
AAQM_0595	COG2996	Protein conserved in bacteria
AAQM_0596	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AAQM_0599	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AAQM_0600	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AAQM_0601	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AAQM_0604	COG0582	viral genome integration into host DNA
AAQM_0610	COG0210	DNA helicase
AAQM_0611	COG0569	domain protein
AAQM_0611	COG0475	glutathione-regulated potassium exporter activity
AAQM_0612	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AAQM_0617	COG3258	Cytochrome c
AAQM_0627	COG0525	valine-tRNA ligase activity
AAQM_0629	COG0454	-acetyltransferase
AAQM_0631	COG4895	conserved protein (DUF2196)
AAQM_0632	COG1047	Peptidyl-prolyl cis-trans
AAQM_0634	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AAQM_0636	COG1917	Cupin 2, conserved barrel domain protein
AAQM_0637	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AAQM_0640	COG0739	heme binding
AAQM_0642	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AAQM_0643	COG0138	bifunctional purine biosynthesis protein purh
AAQM_0648	COG0179	Fumarylacetoacetate (FAA) hydrolase
AAQM_0649	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AAQM_0650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AAQM_0653	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AAQM_0656	COG0542	response to heat
AAQM_0657	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AAQM_0658	COG0594	ribonuclease P activity
AAQM_0659	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AAQM_0660	COG0706	membrane insertase activity
AAQM_0662	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AAQM_0665	COG0501	Belongs to the peptidase M48B family
AAQM_0666	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AAQM_0667	COG0571	ribonuclease III activity
AAQM_0669	COG0358	DNA primase activity
AAQM_0671	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AAQM_0672	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AAQM_0673	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AAQM_0674	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AAQM_0675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AAQM_0677	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AAQM_0677	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AAQM_0678	COG1192	Involved in chromosome partitioning
AAQM_0679	COG1475	DNA binding
AAQM_0681	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AAQM_0682	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AAQM_0683	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AAQM_0684	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AAQM_0685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AAQM_0686	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AAQM_0687	COG0811	peptide transport
AAQM_0688	COG0848	biopolymer transport protein
AAQM_0690	COG0823	Involved in the tonB-independent uptake of proteins
AAQM_0691	COG2193	ferroxidase activity
AAQM_0694	COG1047	Peptidyl-prolyl cis-trans
AAQM_0695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AAQM_0696	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AAQM_0697	COG1115	amino acid carrier protein
AAQM_0699	COG0745	RESPONSE REGULATOR receiver
AAQM_0700	COG1027	Aspartate ammonia-lyase
AAQM_0703	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AAQM_0704	COG0519	Catalyzes the synthesis of GMP from XMP
AAQM_0706	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAQM_0707	COG0010	Belongs to the arginase family
AAQM_0710	COG4773	Receptor
AAQM_0711	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AAQM_0714	COG4335	DNA alkylation repair
AAQM_0719	COG5001	Diguanylate cyclase
AAQM_0719	COG5002	protein histidine kinase activity
AAQM_0722	COG2995	paraquat-inducible protein a
AAQM_0723	COG3008	intermembrane lipid transfer
AAQM_0725	COG3437	response regulator, receiver
AAQM_0726	COG3437	response regulator, receiver
AAQM_0726	COG4999	Histidine kinase
AAQM_0726	COG3850	Histidine kinase
AAQM_0726	COG2205	protein histidine kinase activity
AAQM_0728	COG3920	Histidine kinase
AAQM_0731	COG3111	PFAM Bacterial OB fold (BOF) protein
AAQM_0732	COG0642	Histidine kinase
AAQM_0733	COG0745	RESPONSE REGULATOR receiver
AAQM_0735	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AAQM_0736	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AAQM_0737	COG0326	Molecular chaperone. Has ATPase activity
AAQM_0743	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AAQM_0745	COG1984	allophanate hydrolase subunit 2
AAQM_0750	COG0513	Belongs to the DEAD box helicase family
AAQM_0752	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AAQM_0754	COG0259	pyridoxamine-phosphate oxidase activity
AAQM_0756	COG0720	synthase
AAQM_0757	COG0418	dihydroorotase activity
AAQM_0758	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AAQM_0758	COG0140	phosphoribosyl-ATP diphosphatase activity
AAQM_0759	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AAQM_0766	COG1918	ferrous iron import across plasma membrane
AAQM_0766	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AAQM_0767	COG1918	ferrous iron import across plasma membrane
AAQM_0771	COG4771	TonB-dependent receptor
AAQM_0773	COG0784	Response regulator, receiver
AAQM_0774	COG1538	Outer membrane efflux protein
AAQM_0775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AAQM_0777	COG0500	methyltransferase
AAQM_0778	COG4771	TonB-dependent receptor
AAQM_0782	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AAQM_0783	COG0585	pseudouridine synthase activity
AAQM_0785	COG0840	transmembrane signaling receptor activity
AAQM_0786	COG0632	four-way junction helicase activity
AAQM_0787	COG1181	Belongs to the D-alanine--D-alanine ligase family
AAQM_0788	COG2267	carboxylic ester hydrolase activity
AAQM_0789	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AAQM_0792	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAQM_0793	COG0051	transcription antitermination factor activity, RNA binding
AAQM_0794	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AAQM_0795	COG0088	Forms part of the polypeptide exit tunnel
AAQM_0796	COG0089	rRNA binding
AAQM_0797	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AAQM_0798	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AAQM_0799	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AAQM_0800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AAQM_0801	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AAQM_0802	COG0255	Belongs to the universal ribosomal protein uL29 family
AAQM_0803	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AAQM_0804	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AAQM_0805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AAQM_0806	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AAQM_0807	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AAQM_0808	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AAQM_0809	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AAQM_0810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AAQM_0811	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AAQM_0812	COG0200	Binds to the 23S rRNA
AAQM_0813	COG0201	protein transport
AAQM_0814	COG0024	Methionine aminopeptidase
AAQM_0815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AAQM_0817	COG1573	uracil-dna glycosylase
AAQM_0819	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AAQM_0822	COG1032	radical SAM domain protein
AAQM_0823	COG1280	lysine exporter protein (LysE YggA)
AAQM_0825	COG0563	adenylate kinase activity
AAQM_0829	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AAQM_0830	COG0322	excinuclease ABC activity
AAQM_0831	COG3706	GGDEF domain
AAQM_0833	COG3201	nicotinamide mononucleotide transporter
AAQM_0834	COG0386	Belongs to the glutathione peroxidase family
AAQM_0836	COG0840	transmembrane signaling receptor activity
AAQM_0837	COG0840	transmembrane signaling receptor activity
AAQM_0838	COG0726	polysaccharide deacetylase
AAQM_0847	COG3706	GGDEF domain
AAQM_0848	COG0708	Exodeoxyribonuclease III
AAQM_0854	COG0166	Belongs to the GPI family
AAQM_0863	COG3123	guanosine phosphorylase activity
AAQM_0867	COG0012	GTP binding
AAQM_0868	COG2252	PERMEase
AAQM_0869	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AAQM_0870	COG2363	Small membrane protein
AAQM_0872	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AAQM_0873	COG2233	PERMEase
AAQM_0874	COG1666	GTP binding
AAQM_0876	COG0745	RESPONSE REGULATOR receiver
AAQM_0877	COG0642	Histidine kinase
AAQM_0881	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AAQM_0882	COG0135	phosphoribosylanthranilate isomerase activity
AAQM_0883	COG2176	DNA-directed DNA polymerase activity
AAQM_0884	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AAQM_0886	COG1013	pyruvate-flavodoxin oxidoreductase activity
AAQM_0887	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AAQM_0887	COG0674	pyruvate-flavodoxin oxidoreductase activity
AAQM_0889	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AAQM_0890	COG0727	PFAM Uncharacterised protein family (UPF0153)
AAQM_0892	COG0134	indole-3-glycerol-phosphate synthase activity
AAQM_0893	COG0583	DNA-binding transcription factor activity
AAQM_0894	COG1942	4-Oxalocrotonate Tautomerase
AAQM_0895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AAQM_0896	COG0750	zinc metalloprotease
AAQM_0897	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AAQM_0898	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_0899	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AAQM_0902	COG0167	dihydroorotate dehydrogenase activity
AAQM_0903	COG1132	(ABC) transporter
AAQM_0904	COG0728	peptidoglycan biosynthetic process
AAQM_0906	COG1592	Rubrerythrin
AAQM_0908	COG0530	calcium, potassium:sodium antiporter activity
AAQM_0909	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AAQM_0911	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AAQM_0918	COG1858	cytochrome C peroxidase
AAQM_0921	COG0552	protein localization to endoplasmic reticulum
AAQM_0922	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AAQM_0924	COG1418	mRNA catabolic process
AAQM_0925	COG0742	ribosomal rna small subunit methyltransferase
AAQM_0926	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AAQM_0928	COG0300	oxidoreductase activity
AAQM_0931	COG3258	Cytochrome c
AAQM_0934	COG0642	Histidine kinase
AAQM_0936	COG0157	Belongs to the NadC ModD family
AAQM_0938	COG1610	YqeY-like protein
AAQM_0940	COG0840	transmembrane signaling receptor activity
AAQM_0941	COG0840	transmembrane signaling receptor activity
AAQM_0945	COG0745	RESPONSE REGULATOR receiver
AAQM_0954	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AAQM_0955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AAQM_0956	COG0436	Aminotransferase
AAQM_0959	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AAQM_0960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AAQM_0960	COG0519	Catalyzes the synthesis of GMP from XMP
AAQM_0963	COG2336	PFAM SpoVT AbrB
AAQM_0965	COG0473	3-isopropylmalate dehydrogenase activity
AAQM_0966	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_0967	COG2204	response regulator
AAQM_0975	COG0730	response to heat
AAQM_0976	COG0633	Ferredoxin
AAQM_0976	COG0543	2 iron, 2 sulfur cluster binding
AAQM_0981	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AAQM_0985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AAQM_0986	COG2267	carboxylic ester hydrolase activity
AAQM_0987	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AAQM_0990	COG1605	Chorismate mutase
AAQM_0990	COG0077	Prephenate dehydratase
AAQM_0991	COG2205	protein histidine kinase activity
AAQM_0998	COG0114	fumarate hydratase activity
AAQM_1005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AAQM_1007	COG1643	Atp-dependent helicase
AAQM_1010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AAQM_1014	COG0251	oxidation-reduction process
AAQM_1019	COG0596	Alpha beta hydrolase
AAQM_1020	COG1489	DNA binding
AAQM_1023	COG1696	Membrane protein involved in D-alanine export
AAQM_1024	COG0564	pseudouridine synthase activity
AAQM_1025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AAQM_1027	COG2223	nitrite transmembrane transporter activity
AAQM_1031	COG0300	oxidoreductase activity
AAQM_1032	COG0519	Catalyzes the synthesis of GMP from XMP
AAQM_1032	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AAQM_1041	COG2815	serine threonine protein kinase
AAQM_1041	COG0515	serine threonine protein kinase
AAQM_1044	COG1253	flavin adenine dinucleotide binding
AAQM_1045	COG2989	Protein conserved in bacteria
AAQM_1046	COG0628	permease
AAQM_1049	COG4536	flavin adenine dinucleotide binding
AAQM_1052	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AAQM_1054	COG1309	transcriptional regulator
AAQM_1057	COG0513	Belongs to the DEAD box helicase family
AAQM_1059	COG1045	serine acetyltransferase
AAQM_1060	COG1166	arginine decarboxylase activity
AAQM_1061	COG0124	histidyl-tRNA synthetase
AAQM_1062	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AAQM_1063	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AAQM_1064	COG0163	prenyltransferase activity
AAQM_1066	COG0359	binds to the 23S rRNA
AAQM_1067	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AAQM_1068	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AAQM_1070	COG0084	hydrolase, TatD family'
AAQM_1072	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AAQM_1073	COG0131	Imidazoleglycerol-phosphate dehydratase
AAQM_1074	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AAQM_1077	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AAQM_1078	COG0456	acetyltransferase
AAQM_1079	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AAQM_1080	COG3576	pyridoxamine 5-phosphate
AAQM_1086	COG1338	Plays a role in the flagellum-specific transport system
AAQM_1097	COG0849	cell division
AAQM_1098	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AAQM_1101	COG0408	coproporphyrinogen oxidase activity
AAQM_1103	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AAQM_1105	COG1193	negative regulation of DNA recombination
AAQM_1109	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AAQM_1111	COG1119	ATPase activity
AAQM_1114	COG1605	Chorismate mutase
AAQM_1114	COG0077	Prephenate dehydratase
AAQM_1119	COG1396	sequence-specific DNA binding
AAQM_1122	COG2824	Alkylphosphonate utilization operon protein PhnA
AAQM_1129	COG1881	PFAM PEBP family protein
AAQM_1131	COG0840	transmembrane signaling receptor activity
AAQM_1134	COG0643	Histidine kinase
AAQM_1134	COG2198	Histidine kinase
AAQM_1135	COG2197	response regulator
AAQM_1137	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AAQM_1138	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AAQM_1140	COG3437	response regulator, receiver
AAQM_1140	COG0784	Response regulator, receiver
AAQM_1142	COG3040	lipid binding
AAQM_1145	COG3046	protein related to deoxyribodipyrimidine photolyase
AAQM_1148	COG2199	diguanylate cyclase activity
AAQM_1148	COG2200	EAL domain
AAQM_1148	COG3287	FIST C domain
AAQM_1150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AAQM_1153	COG3040	lipid binding
AAQM_1155	COG0300	oxidoreductase activity
AAQM_1157	COG0488	(ABC) transporter
AAQM_1158	COG1607	acyl-coa hydrolase
AAQM_1159	COG3437	response regulator, receiver
AAQM_1159	COG0784	Response regulator, receiver
AAQM_1161	COG0840	transmembrane signaling receptor activity
AAQM_1162	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AAQM_1165	COG1733	regulation of RNA biosynthetic process
AAQM_1166	COG2249	NAD(P)H dehydrogenase (quinone) activity
AAQM_1169	COG0778	Nitroreductase
AAQM_1172	COG4191	Histidine kinase
AAQM_1174	COG0776	regulation of translation
AAQM_1176	COG0275	rRNA processing
AAQM_1182	COG0318	PFAM AMP-dependent synthetase and ligase
AAQM_1184	COG4865	methylaspartate mutase activity
AAQM_1187	COG0039	L-malate dehydrogenase activity
AAQM_1191	COG4591	ABC-type transport system involved in lipoprotein release permease component
AAQM_1192	COG0653	protein targeting
AAQM_1193	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AAQM_1196	COG1879	ABC-type sugar transport system periplasmic component
AAQM_1197	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAQM_1197	COG4191	Histidine kinase
AAQM_1198	COG0754	glutathionylspermidine amidase activity
AAQM_1200	COG0640	Transcriptional regulator
AAQM_1203	COG2059	Chromate
AAQM_1206	COG0840	transmembrane signaling receptor activity
AAQM_1208	COG0824	Thioesterase
AAQM_1210	COG0501	Belongs to the peptidase M48B family
AAQM_1211	COG1322	Protein conserved in bacteria
AAQM_1216	COG0037	tRNA processing
AAQM_1221	COG5001	Diguanylate cyclase
AAQM_1221	COG4251	negative regulation of phosphorylation
AAQM_1221	COG2203	Gaf domain
AAQM_1221	COG3706	GGDEF domain
AAQM_1223	COG0248	Ppx GppA phosphatase
AAQM_1225	COG0028	Belongs to the TPP enzyme family
AAQM_1226	COG0440	acetolactate synthase activity
AAQM_1227	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AAQM_1228	COG1196	nuclear chromosome segregation
AAQM_1228	COG1674	ftsk spoiiie
AAQM_1230	COG1160	GTP binding
AAQM_1231	COG0659	secondary active sulfate transmembrane transporter activity
AAQM_1235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AAQM_1237	COG1185	polyribonucleotide nucleotidyltransferase activity
AAQM_1240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AAQM_1241	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AAQM_1242	COG2201	protein-glutamate methylesterase activity
AAQM_1246	COG0582	viral genome integration into host DNA
AAQM_1256	COG0514	ATP-dependent DNA helicase (RecQ)
AAQM_1257	COG0582	viral genome integration into host DNA
AAQM_1258	COG3842	ATPase activity
AAQM_1266	COG0339	signal peptide processing
AAQM_1267	COG2890	protein-(glutamine-N5) methyltransferase activity
AAQM_1268	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AAQM_1269	COG0494	nUDIX hydrolase
AAQM_1270	COG0527	aspartate kinase activity
AAQM_1273	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AAQM_1274	COG0287	Prephenate dehydrogenase
AAQM_1275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AAQM_1276	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AAQM_1277	COG0612	Peptidase, M16
AAQM_1278	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AAQM_1284	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AAQM_1286	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAQM_1286	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAQM_1290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAQM_1291	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AAQM_1292	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AAQM_1320	COG0788	formyltetrahydrofolate deformylase activity
AAQM_1321	COG0280	phosphate acetyltransferase
AAQM_1321	COG0281	malic enzyme
AAQM_1324	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AAQM_1337	COG0582	viral genome integration into host DNA
AAQM_1340	COG0667	Aldo Keto reductase
AAQM_1345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AAQM_1348	COG4206	TonB-dependent receptor
AAQM_1355	COG1187	pseudouridine synthase activity
AAQM_1356	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AAQM_1357	COG3706	GGDEF domain
AAQM_1360	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AAQM_1361	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AAQM_1365	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AAQM_1368	COG0419	ATPase involved in DNA repair
AAQM_1371	COG0848	biopolymer transport protein
AAQM_1372	COG0811	peptide transport
AAQM_1374	COG4771	TonB-dependent receptor
AAQM_1380	COG0330	HflC and HflK could
AAQM_1382	COG0745	RESPONSE REGULATOR receiver
AAQM_1385	COG0751	glycine-tRNA ligase activity
AAQM_1389	COG0357	Ribosomal RNA small subunit methyltransferase G
AAQM_1390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AAQM_1391	COG0113	porphobilinogen synthase activity
AAQM_1396	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AAQM_1396	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAQM_1397	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AAQM_1398	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AAQM_1400	COG1663	tetraacyldisaccharide 4'-kinase activity
AAQM_1402	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AAQM_1406	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AAQM_1407	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AAQM_1408	COG0805	protein transport
AAQM_1409	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AAQM_1455	COG4608	Belongs to the ABC transporter superfamily
AAQM_1466	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AAQM_1468	COG0247	lactate metabolic process
AAQM_1468	COG2181	nitrate reductase activity
AAQM_1469	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AAQM_1473	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AAQM_1473	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AAQM_1474	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AAQM_1475	COG2199	diguanylate cyclase activity
AAQM_1475	COG3287	FIST C domain
AAQM_1475	COG2200	EAL domain
AAQM_1476	COG3706	GGDEF domain
AAQM_1477	COG1137	ATPase activity
AAQM_1478	COG0802	atpase or kinase
AAQM_1479	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AAQM_1481	COG4771	TonB-dependent receptor
AAQM_1483	COG0137	argininosuccinate synthase activity
AAQM_1488	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AAQM_1489	COG0484	heat shock protein binding
AAQM_1490	COG0133	tryptophan synthase activity
AAQM_1494	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AAQM_1495	COG5001	Diguanylate cyclase
AAQM_1496	COG2203	Gaf domain
AAQM_1496	COG4251	negative regulation of phosphorylation
AAQM_1496	COG3706	GGDEF domain
AAQM_1496	COG5001	Diguanylate cyclase
AAQM_1497	COG0500	methyltransferase
AAQM_1498	COG1333	cytochrome c biogenesis protein
AAQM_1498	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AAQM_1499	COG0745	RESPONSE REGULATOR receiver
AAQM_1501	COG2195	Cleaves the N-terminal amino acid of tripeptides
AAQM_1505	COG2201	protein-glutamate methylesterase activity
AAQM_1508	COG0484	heat shock protein binding
AAQM_1509	COG0789	Transcriptional regulator
AAQM_1512	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AAQM_1514	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AAQM_1515	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AAQM_1517	COG0471	metal ion transport
AAQM_1518	COG0521	Mo-molybdopterin cofactor biosynthetic process
AAQM_1520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AAQM_1521	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AAQM_1523	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AAQM_1525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AAQM_1527	COG3279	Response regulator of the LytR AlgR family
AAQM_1537	COG0642	Histidine kinase
AAQM_1538	COG0745	RESPONSE REGULATOR receiver
AAQM_1542	COG1132	(ABC) transporter
AAQM_1543	COG0628	permease
AAQM_1545	COG5001	Diguanylate cyclase
AAQM_1545	COG3300	MHYT domain
AAQM_1546	COG3118	belongs to the thioredoxin family
AAQM_1547	COG0450	alkyl hydroperoxide reductase
AAQM_1549	COG2205	protein histidine kinase activity
AAQM_1549	COG0784	Response regulator, receiver
AAQM_1549	COG5002	protein histidine kinase activity
AAQM_1551	COG1472	Belongs to the glycosyl hydrolase 3 family
AAQM_1555	COG1620	l-lactate permease
AAQM_1562	COG0745	RESPONSE REGULATOR receiver
AAQM_1565	COG1047	Peptidyl-prolyl cis-trans
AAQM_1566	COG0517	IMP dehydrogenase activity
AAQM_1566	COG0516	GMP reductase activity
AAQM_1567	COG0154	amidase activity
AAQM_1568	COG0203	ribosomal protein L17
AAQM_1569	COG0202	RNA polymerase activity
AAQM_1570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AAQM_1571	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AAQM_1572	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AAQM_1573	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AAQM_1576	COG0473	3-isopropylmalate dehydrogenase activity
AAQM_1577	COG0066	3-isopropylmalate dehydratase activity
AAQM_1578	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AAQM_1582	COG3123	guanosine phosphorylase activity
AAQM_1583	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AAQM_1587	COG0772	Belongs to the SEDS family
AAQM_1588	COG0564	pseudouridine synthase activity
AAQM_1589	COG0366	Alpha amylase catalytic
AAQM_1589	COG3103	Sh3 type 3 domain protein
AAQM_1590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AAQM_1591	COG2884	Cell division ATP-binding protein ftsE
AAQM_1594	COG1671	Belongs to the UPF0178 family
AAQM_1596	COG0488	(ABC) transporter
AAQM_1602	COG2171	N-acyltransferase activity
AAQM_1603	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AAQM_1609	COG0309	Hydrogenase expression formation protein (HypE)
AAQM_1611	COG1401	restriction endodeoxyribonuclease activity
AAQM_1613	COG0409	Hydrogenase expression formation protein
AAQM_1614	COG0298	carbon dioxide binding
AAQM_1615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AAQM_1619	COG0310	cobalt ion transport
AAQM_1623	COG2081	HI0933 family
AAQM_1626	COG2814	Major facilitator Superfamily
AAQM_1628	COG0301	tRNA thio-modification
AAQM_1628	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AAQM_1631	COG3263	regulation of cellular component size
AAQM_1634	COG0517	IMP dehydrogenase activity
AAQM_1638	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AAQM_1641	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AAQM_1642	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AAQM_1643	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AAQM_1644	COG3259	Nickel-dependent hydrogenase
AAQM_1647	COG1049	propionate catabolic process, 2-methylcitrate cycle
AAQM_1648	COG3706	GGDEF domain
AAQM_1648	COG5001	Diguanylate cyclase
AAQM_1648	COG4251	negative regulation of phosphorylation
AAQM_1648	COG2203	Gaf domain
AAQM_1650	COG1022	Amp-dependent synthetase and ligase
AAQM_1651	COG0183	Belongs to the thiolase family
AAQM_1652	COG1024	Enoyl-CoA hydratase
AAQM_1652	COG1250	3-hydroxyacyl-CoA dehydrogenase
AAQM_1653	COG1960	acyl-CoA dehydrogenase activity
AAQM_1660	COG0217	transcriptional regulatory protein
AAQM_1661	COG0739	heme binding
AAQM_1662	COG2853	Lipoprotein
AAQM_1665	COG1611	Belongs to the LOG family
AAQM_1666	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AAQM_1671	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AAQM_1675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AAQM_1680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AAQM_1681	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AAQM_1681	COG2169	Transcriptional regulator
AAQM_1684	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AAQM_1685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AAQM_1686	COG2258	MOSC domain
AAQM_1690	COG0513	Belongs to the DEAD box helicase family
AAQM_1691	COG1944	ATP diphosphatase activity
AAQM_1695	COG0840	transmembrane signaling receptor activity
AAQM_1696	COG0328	RNA-DNA hybrid ribonuclease activity
AAQM_1699	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AAQM_1701	COG0446	pyridine nucleotide-disulphide oxidoreductase
AAQM_1703	COG1104	cysteine desulfurase activity
AAQM_1705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AAQM_1707	COG0437	4 iron, 4 sulfur cluster binding
AAQM_1710	COG3381	protein complex oligomerization
AAQM_1714	COG4565	transcriptional regulatory protein
AAQM_1718	COG1305	Transglutaminase-like
AAQM_1721	COG1921	L-seryl-tRNASec selenium transferase activity
AAQM_1728	COG2204	response regulator
AAQM_1731	COG3850	Histidine kinase
AAQM_1731	COG4999	Histidine kinase
AAQM_1731	COG2205	protein histidine kinase activity
AAQM_1731	COG3437	response regulator, receiver
AAQM_1733	COG2205	protein histidine kinase activity
AAQM_1733	COG0784	Response regulator, receiver
AAQM_1739	COG0735	belongs to the Fur family
AAQM_1749	COG0577	efflux transmembrane transporter activity
AAQM_1749	COG1136	(ABC) transporter
AAQM_1750	COG1136	(ABC) transporter
AAQM_1750	COG0577	efflux transmembrane transporter activity
AAQM_1754	COG0848	biopolymer transport protein
AAQM_1756	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AAQM_1758	COG0133	tryptophan synthase activity
AAQM_1759	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AAQM_1760	COG1793	dna ligase
AAQM_1762	COG0305	Participates in initiation and elongation during chromosome replication
AAQM_1764	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AAQM_1767	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AAQM_1768	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AAQM_1770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AAQM_1771	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AAQM_1772	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AAQM_1774	COG0528	UMP kinase activity
AAQM_1775	COG1758	RNA polymerase activity
AAQM_1777	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AAQM_1779	COG0860	N-Acetylmuramoyl-L-alanine amidase
AAQM_1782	COG0193	aminoacyl-tRNA hydrolase activity
AAQM_1783	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AAQM_1784	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AAQM_1785	COG0681	Belongs to the peptidase S26 family
AAQM_1786	COG0698	ribose 5-phosphate isomerase
AAQM_1794	COG0556	nucleotide-excision repair
AAQM_1797	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AAQM_1798	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AAQM_1799	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AAQM_1800	COG0784	Response regulator, receiver
AAQM_1800	COG0835	chemotaxis
AAQM_1801	COG0165	Argininosuccinate lyase
AAQM_1805	COG3706	GGDEF domain
AAQM_1807	COG2239	Acts as a magnesium transporter
AAQM_1809	COG2906	2 iron, 2 sulfur cluster binding
AAQM_1809	COG0822	iron-sulfur transferase activity
AAQM_1809	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AAQM_1811	COG0719	Fe-S assembly protein
AAQM_1812	COG0396	ATPase activity
AAQM_1814	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AAQM_1815	COG2166	iron-sulfur cluster assembly
AAQM_1818	COG0840	transmembrane signaling receptor activity
AAQM_1820	COG0439	Biotin carboxylase
AAQM_1821	COG3706	GGDEF domain
AAQM_1828	COG1309	transcriptional regulator
AAQM_1829	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AAQM_1830	COG2203	Gaf domain
AAQM_1830	COG2199	diguanylate cyclase activity
AAQM_1831	COG0840	transmembrane signaling receptor activity
AAQM_1832	COG0840	transmembrane signaling receptor activity
AAQM_1838	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AAQM_1839	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AAQM_1840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AAQM_1844	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AAQM_1845	COG2814	Major facilitator Superfamily
AAQM_1847	COG3706	GGDEF domain
AAQM_1848	COG0302	gtp cyclohydrolase
AAQM_1849	COG0598	Magnesium transport protein CorA
AAQM_1850	COG1459	type II secretion system
AAQM_1851	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AAQM_1854	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AAQM_1855	COG0606	chelatase, subunit chli
AAQM_1857	COG0242	peptide deformylase activity
AAQM_1858	COG0740	serine-type endopeptidase activity
AAQM_1859	COG0544	peptidyl-prolyl cis-trans isomerase activity
AAQM_1860	COG2304	oxidoreductase activity
AAQM_1861	COG2326	polyphosphate kinase activity
AAQM_1864	COG1773	rubredoxin
AAQM_1867	COG0582	viral genome integration into host DNA
AAQM_1881	COG3077	Addiction module antitoxin, RelB DinJ family
AAQM_1886	COG4681	YaeQ
AAQM_1890	COG0626	cystathionine gamma-synthase activity
AAQM_1894	COG0745	RESPONSE REGULATOR receiver
AAQM_1896	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AAQM_1899	COG2111	Na H antiporter
AAQM_1899	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AAQM_1900	COG1006	Multisubunit Na H antiporter MnhC subunit
AAQM_1901	COG0651	ATP synthesis coupled electron transport
AAQM_1902	COG1863	multisubunit Na H antiporter MnhE subunit
AAQM_1903	COG2212	antiporter activity
AAQM_1904	COG1320	monovalent cation:proton antiporter activity
AAQM_1905	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_1907	COG1858	cytochrome C peroxidase
AAQM_1913	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AAQM_1915	COG0668	transmembrane transport
AAQM_1921	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AAQM_1924	COG0348	domain, Protein
AAQM_1925	COG4191	Histidine kinase
AAQM_1926	COG4753	response regulator
AAQM_1926	COG2207	Transcriptional regulator
AAQM_1934	COG0716	FMN binding
AAQM_1937	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AAQM_1940	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AAQM_1941	COG0159	tryptophan synthase activity
AAQM_1942	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AAQM_1943	COG2255	four-way junction helicase activity
AAQM_1944	COG0628	permease
AAQM_1946	COG4628	conserved protein (DUF2132)
AAQM_1955	COG0731	radical SAM domain protein
AAQM_1956	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AAQM_1958	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AAQM_1960	COG2841	Protein conserved in bacteria
AAQM_1961	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AAQM_1963	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AAQM_1967	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AAQM_1967	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AAQM_1968	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AAQM_1969	COG0859	PFAM glycosyl transferase family 9
AAQM_1972	COG1216	Glycosyl transferase, family 2
AAQM_1975	COG0438	transferase activity, transferring glycosyl groups
AAQM_1978	COG1696	Membrane protein involved in D-alanine export
AAQM_1980	COG1696	Membrane protein involved in D-alanine export
AAQM_1982	COG1216	Glycosyl transferase, family 2
AAQM_1984	COG1216	Glycosyl transferase, family 2
AAQM_1992	COG0859	PFAM glycosyl transferase family 9
AAQM_1994	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AAQM_1996	COG0493	'glutamate synthase
AAQM_1997	COG0070	glutamate synthase
AAQM_1997	COG0067	glutamate synthase
AAQM_1997	COG0069	glutamate synthase activity
AAQM_1998	COG0584	glycerophosphoryl diester phosphodiesterase
AAQM_2011	COG1086	Polysaccharide biosynthesis protein
AAQM_2013	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AAQM_2018	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AAQM_2024	COG0463	Glycosyl transferase, family 2
AAQM_2029	COG0028	Belongs to the TPP enzyme family
AAQM_2035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AAQM_2036	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AAQM_2037	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AAQM_2038	COG0284	orotidine-5'-phosphate decarboxylase activity
AAQM_2041	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AAQM_2046	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AAQM_2050	COG1739	Uncharacterized protein family UPF0029
AAQM_2051	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AAQM_2052	COG0196	riboflavin kinase activity
AAQM_2053	COG2226	methyltransferase
AAQM_2054	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AAQM_2056	COG0277	FAD linked oxidase domain protein
AAQM_2057	COG1295	ribonuclease BN
AAQM_2067	COG0542	response to heat
AAQM_2068	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AAQM_2069	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AAQM_2072	COG2030	dehydratase
AAQM_2077	COG1970	mechanosensitive ion channel activity
AAQM_2078	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AAQM_2084	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AAQM_2085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AAQM_2086	COG1157	protein secretion by the type III secretion system
AAQM_2088	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AAQM_2092	COG1677	Flagellar hook-basal body complex protein FliE
AAQM_2094	COG0455	bacterial-type flagellum organization
AAQM_2095	COG1419	protein localization to endoplasmic reticulum
AAQM_2100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AAQM_2105	COG1749	Flagellar hook protein flgE
AAQM_2106	COG4786	Flagellar basal body rod
AAQM_2108	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AAQM_2110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AAQM_2111	COG1766	The M ring may be actively involved in energy transduction
AAQM_2112	COG1815	bacterial-type flagellum-dependent cell motility
AAQM_2113	COG4786	Flagellar basal body rod
AAQM_2115	COG0745	RESPONSE REGULATOR receiver
AAQM_2119	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AAQM_2121	COG0228	four-way junction DNA binding
AAQM_2122	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AAQM_2123	COG0564	pseudouridine synthase activity
AAQM_2124	COG1519	Transferase
AAQM_2126	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AAQM_2127	COG0752	glycyl-tRNA synthetase alpha subunit
AAQM_2129	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AAQM_2132	COG0840	transmembrane signaling receptor activity
AAQM_2132	COG0840	transmembrane signaling receptor activity
AAQM_2133	COG0497	DNA recombination
AAQM_2134	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AAQM_2135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AAQM_2136	COG0049	tRNA binding
AAQM_2137	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AAQM_2138	COG2814	Major facilitator Superfamily
AAQM_2146	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AAQM_2147	COG0085	RNA polymerase activity
AAQM_2148	COG0222	ribosome binding
AAQM_2149	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AAQM_2150	COG0081	regulation of translation
AAQM_2151	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AAQM_2152	COG0250	Participates in transcription elongation, termination and antitermination
AAQM_2155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AAQM_2156	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AAQM_2162	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AAQM_2163	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AAQM_2164	COG0444	Belongs to the ABC transporter superfamily
AAQM_2166	COG0174	glutamine synthetase
AAQM_2169	COG0314	molybdopterin synthase activity
AAQM_2171	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AAQM_2174	COG0772	Belongs to the SEDS family
AAQM_2176	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AAQM_2184	COG0512	Glutamine amidotransferase of anthranilate synthase
AAQM_2185	COG1840	ABC-type Fe3 transport system, periplasmic component
AAQM_2187	COG3842	ATPase activity
AAQM_2193	COG2183	response to ionizing radiation
AAQM_2195	COG5001	Diguanylate cyclase
AAQM_2195	COG5002	protein histidine kinase activity
AAQM_2196	COG0251	oxidation-reduction process
AAQM_2199	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AAQM_2202	COG0335	large ribosomal subunit rRNA binding
AAQM_2203	COG0336	Belongs to the RNA methyltransferase TrmD family
AAQM_2205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AAQM_2206	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AAQM_2207	COG0356	it plays a direct role in the translocation of protons across the membrane
AAQM_2208	COG0352	thiamine-phosphate diphosphorylase activity
AAQM_2209	COG1074	ATP-dependent DNA helicase activity
AAQM_2210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AAQM_2211	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AAQM_2212	COG0723	plastoquinol--plastocyanin reductase activity
AAQM_2213	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AAQM_2216	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AAQM_2219	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AAQM_2221	COG0602	queuosine metabolic process
AAQM_2222	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_2223	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAQM_2224	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AAQM_2225	COG0825	malonyl-CoA metabolic process
AAQM_2226	COG0537	adenosine 5'-monophosphoramidase activity
AAQM_2227	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AAQM_2228	COG0072	phenylalanine-tRNA ligase activity
AAQM_2228	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAQM_2229	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AAQM_2230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AAQM_2231	COG0539	negative regulation of cytoplasmic translation
AAQM_2231	COG1185	polyribonucleotide nucleotidyltransferase activity
AAQM_2232	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AAQM_2233	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AAQM_2234	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAQM_2234	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAQM_2235	COG0779	Required for maturation of 30S ribosomal subunits
AAQM_2236	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AAQM_2237	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AAQM_2239	COG0083	homoserine kinase activity
AAQM_2241	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AAQM_2243	COG2404	hydrolase activity, acting on ester bonds
AAQM_2244	COG0157	Belongs to the NadC ModD family
AAQM_2246	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AAQM_2248	COG4773	Receptor
AAQM_2250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AAQM_2258	COG3278	Belongs to the heme-copper respiratory oxidase family
AAQM_2259	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AAQM_2260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AAQM_2261	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AAQM_2262	COG0210	DNA helicase
AAQM_2264	COG1242	4 iron, 4 sulfur cluster binding
AAQM_2265	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AAQM_2266	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AAQM_2267	COG0492	ferredoxin-NADP+ reductase activity
AAQM_2268	COG3118	belongs to the thioredoxin family
AAQM_2269	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AAQM_2274	COG0791	NLP P60 protein
AAQM_2275	COG0791	NLP P60 protein
AAQM_2277	COG0697	spore germination
AAQM_2278	COG0424	maF-like protein
AAQM_2280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AAQM_2281	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AAQM_2282	COG1605	Chorismate mutase
AAQM_2282	COG0077	Prephenate dehydratase
AAQM_2283	COG0019	diaminopimelate decarboxylase activity
AAQM_2284	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AAQM_2285	COG0149	triose-phosphate isomerase activity
AAQM_2286	COG0126	phosphoglycerate kinase activity
AAQM_2287	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AAQM_2288	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AAQM_2290	COG0018	arginyl-trna synthetase
AAQM_2291	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AAQM_2292	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AAQM_2293	COG0204	Acyl-transferase
AAQM_2295	COG0047	phosphoribosylformylglycinamidine synthase activity
AAQM_2296	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AAQM_2297	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AAQM_2298	COG0793	Belongs to the peptidase S41A family
AAQM_2301	COG0585	pseudouridine synthase activity
AAQM_2304	COG1136	(ABC) transporter
AAQM_2304	COG0577	efflux transmembrane transporter activity
AAQM_2318	COG0129	dihydroxy-acid dehydratase activity
AAQM_2320	COG0745	RESPONSE REGULATOR receiver
AAQM_2321	COG0642	Histidine kinase
AAQM_2323	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AAQM_2324	COG0702	epimerase
AAQM_2325	COG1492	cobalamin metabolic process
AAQM_2331	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AAQM_2332	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AAQM_2334	COG2095	MarC family integral membrane protein
AAQM_2335	COG2755	lipolytic protein G-D-S-L family
AAQM_2335	COG1083	cytidylyl-transferase
AAQM_2336	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AAQM_2339	COG4232	protein-disulfide reductase activity
AAQM_2340	COG3118	belongs to the thioredoxin family
AAQM_2341	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AAQM_2344	COG0189	ligase activity
AAQM_2347	COG2199	diguanylate cyclase activity
AAQM_2347	COG2200	EAL domain
AAQM_2347	COG3287	FIST C domain
AAQM_2348	COG0688	phosphatidylethanolamine metabolic process
AAQM_2350	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AAQM_2352	COG0443	Heat shock 70 kDa protein
AAQM_2353	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AAQM_2357	COG2204	response regulator
AAQM_2359	COG0101	tRNA pseudouridine synthase activity
AAQM_2361	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AAQM_2362	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AAQM_2363	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AAQM_2364	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AAQM_2366	COG4581	dead DEAH box helicase
AAQM_2367	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AAQM_2371	COG2089	acid synthase
AAQM_2374	COG1083	cytidylyl-transferase
AAQM_2375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AAQM_2376	COG1086	Polysaccharide biosynthesis protein
AAQM_2381	COG0673	inositol 2-dehydrogenase activity
AAQM_2386	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AAQM_2387	COG0148	phosphopyruvate hydratase activity
AAQM_2390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AAQM_2393	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AAQM_2394	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AAQM_2396	COG1007	ATP synthesis coupled electron transport
AAQM_2398	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AAQM_2399	COG0713	ATP synthesis coupled electron transport
AAQM_2400	COG0839	Belongs to the complex I subunit 6 family
AAQM_2401	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_2402	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AAQM_2406	COG0649	NAD binding
AAQM_2407	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_2408	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_2409	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_2410	COG1222	aaa ATPase
AAQM_2415	COG0659	secondary active sulfate transmembrane transporter activity
AAQM_2416	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AAQM_2417	COG1252	NADH dehydrogenase
AAQM_2418	COG0733	neurotransmitter:sodium symporter activity
AAQM_2420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AAQM_2422	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AAQM_2423	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AAQM_2424	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AAQM_2428	COG0445	tRNA wobble uridine modification
AAQM_2430	COG0708	Exodeoxyribonuclease III
AAQM_2432	COG0210	DNA helicase
AAQM_2439	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AAQM_2444	COG0348	domain, Protein
AAQM_2445	COG0504	CTP synthase activity
AAQM_2446	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AAQM_2446	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AAQM_2452	COG0587	DNA-directed DNA polymerase activity
AAQM_2453	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AAQM_2455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AAQM_2456	COG0315	cyclic pyranopterin monophosphate synthase activity
AAQM_2463	COG0670	Belongs to the BI1 family
AAQM_2464	COG0352	thiamine-phosphate diphosphorylase activity
AAQM_2466	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AAQM_2468	COG0233	cytoplasmic translational termination
AAQM_2469	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AAQM_2471	COG2814	Major facilitator Superfamily
AAQM_2472	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AAQM_2472	COG3264	Mechanosensitive ion channel
AAQM_2474	COG3022	response to hydroperoxide
AAQM_2475	COG3012	SEC-C Motif Domain Protein
AAQM_2480	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AAQM_2481	COG1012	belongs to the aldehyde dehydrogenase family
AAQM_2483	COG1704	LemA family
AAQM_2486	COG0546	phosphoglycolate phosphatase activity
AAQM_2489	COG2814	Major facilitator Superfamily
AAQM_2490	COG0840	transmembrane signaling receptor activity
AAQM_2497	COG2081	HI0933 family
AAQM_2500	COG1959	2 iron, 2 sulfur cluster binding
AAQM_2503	COG0175	sulfate reduction
AAQM_2504	COG0175	sulfate reduction
AAQM_2505	COG2895	sulfate adenylyltransferase (ATP) activity
AAQM_2506	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AAQM_2510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AAQM_2511	COG1408	metallophosphoesterase
AAQM_2512	COG0071	Belongs to the small heat shock protein (HSP20) family
AAQM_2515	COG1305	Transglutaminase-like
AAQM_2516	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AAQM_2517	COG4208	sulfate ABC transporter
AAQM_2518	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AAQM_2519	COG2199	diguanylate cyclase activity
AAQM_2519	COG2200	EAL domain
AAQM_2519	COG3287	FIST C domain
AAQM_2520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AAQM_2521	COG1959	2 iron, 2 sulfur cluster binding
AAQM_2525	COG2308	Evidence 4 Homologs of previously reported genes of
AAQM_2527	COG1368	sulfuric ester hydrolase activity
AAQM_2530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AAQM_2534	COG0745	RESPONSE REGULATOR receiver
AAQM_2535	COG0642	Histidine kinase
AAQM_2537	COG0425	Belongs to the sulfur carrier protein TusA family
AAQM_2538	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AAQM_2539	COG2066	Belongs to the glutaminase family
AAQM_2540	COG2860	membrane
AAQM_2542	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AAQM_2543	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group