locus-tag	class	description
ACAN_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
ACAN_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
ACAN_0003	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
ACAN_0006	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
ACAN_0008	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
ACAN_0012	ENOG4105W39	Membrane
ACAN_0013	ENOG4105BZU	Histidine kinase
ACAN_0014	ENOG4105EI2	Pseudouridine synthase
ACAN_0015	ENOG4107QTF	adenylosuccinate lyase
ACAN_0016	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ACAN_0017	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ACAN_0019	ENOG4108DBC	nitroreductase
ACAN_0020	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
ACAN_0021	ENOG4105BZ8	glutamate synthase
ACAN_0028	ENOG4105CA0	peroxidase
ACAN_0030	ENOG4107VQW	regulatoR
ACAN_0031	ENOG4105BZU	Histidine kinase
ACAN_0032	ENOG4105D05	Receptor
ACAN_0034	ENOG4105GR3	Histidine kinase
ACAN_0035	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
ACAN_0036	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
ACAN_0037	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
ACAN_0038	ENOG4105C58	cytochrome c oxidase accessory protein ccog
ACAN_0039	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
ACAN_0043	ENOG4105KVH	Transcriptional regulator
ACAN_0044	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
ACAN_0045	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
ACAN_0048	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
ACAN_0049	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
ACAN_0050	ENOG4105CN5	Metallo-Beta-Lactamase
ACAN_0051	ENOG4105C2X	Arabinose 5-phosphate isomerase
ACAN_0052	ENOG4105FE9	pseudouridine synthase
ACAN_0053	ENOG4105D1H	recombination factor protein RarA
ACAN_0054	ENOG4108YXA	Membrane
ACAN_0055	ENOG4108IAB	Phoh family
ACAN_0056	ENOG4105C5I	Dehydrogenase
ACAN_0058	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0059	ENOG4105CH5	extracellular solute-binding protein, family 7
ACAN_0060	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
ACAN_0062	ENOG4105CAQ	asparagine synthetase
ACAN_0064	ENOG4105CJ3	phosphate transporter
ACAN_0066	ENOG4105C1J	atp-dependent rna helicase
ACAN_0067	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
ACAN_0068	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
ACAN_0071	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
ACAN_0072	ENOG4107QR9	Iron-sulfur cluster binding protein
ACAN_0073	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
ACAN_0074	ENOG4105BZU	Histidine kinase
ACAN_0076	ENOG4105CH5	extracellular solute-binding protein, family 7
ACAN_0078	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
ACAN_0080	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
ACAN_0081	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ACAN_0082	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
ACAN_0083	ENOG4105BZU	Histidine kinase
ACAN_0084	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_0086	ENOG4108J2R	molybdopterin oxidoreductase
ACAN_0092	ENOG4108IJF	Heavy metal efflux pump, CzcA
ACAN_0093	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
ACAN_0096	ENOG4105BZU	Histidine kinase
ACAN_0097	ENOG4108STX	response regulator
ACAN_0100	ENOG4105E18	UPF0276 protein
ACAN_0102	ENOG4105BZU	Histidine kinase
ACAN_0107	ENOG4105D6E	homoserine dehydrogenase
ACAN_0108	ENOG4105CHM	Aminotransferase
ACAN_0110	ENOG4105C2N	RNA methyltransferase TrmH family group 3
ACAN_0111	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0113	ENOG41082DI	50s ribosomal protein l31
ACAN_0114	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
ACAN_0117	ENOG41064RH	membrane protein YliF
ACAN_0134	ENOG4105D29	Helix-turn-helix type 11 domain protein
ACAN_0148	ENOG4105CJW	magnesium transporter
ACAN_0152	ENOG4105C3M	thioredoxin reductase
ACAN_0153	ENOG4105D3R	alkyl hydroperoxide reductase
ACAN_0154	ENOG4105BZU	Histidine kinase
ACAN_0156	ENOG4105BZU	Histidine kinase
ACAN_0157	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
ACAN_0158	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
ACAN_0159	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
ACAN_0160	ENOG41084QV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
ACAN_0161	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
ACAN_0163	ENOG4108YYC	ycei family
ACAN_0167	ENOG4107UUH	Aminotransferase
ACAN_0168	ENOG4105CYE	ATP phosphoribosyltransferase regulatory subunit
ACAN_0169	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
ACAN_0171	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
ACAN_0174	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
ACAN_0176	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
ACAN_0177	ENOG4105D1F	ATP-binding protein
ACAN_0179	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
ACAN_0181	ENOG4105CM2	brancheD-chain amino acid aminotransferase
ACAN_0192	ENOG4105CQB	FAD linked oxidase domain protein
ACAN_0194	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAN_0195	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
ACAN_0197	ENOG4105DX0	Hemolysin A
ACAN_0198	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
ACAN_0199	ENOG4105GVR	general secretion pathway protein D
ACAN_0202	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
ACAN_0204	ENOG4105CBC	glutamate synthase
ACAN_0207	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
ACAN_0208	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
ACAN_0209	ENOG4105M7K	Involved in the transcription termination process (By similarity)
ACAN_0210	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
ACAN_0228	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
ACAN_0229	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
ACAN_0230	ENOG4107XGZ	Hydrolase
ACAN_0231	ENOG4105DEF	Extracellular solute-binding protein, family 5
ACAN_0232	ENOG4108UJD	30S ribosomal protein S9
ACAN_0233	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
ACAN_0234	ENOG4105BZU	Histidine kinase
ACAN_0235	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_0238	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
ACAN_0240	ENOG4105C8U	phosphate abc transporter
ACAN_0241	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
ACAN_0243	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
ACAN_0244	ENOG4108317	Binds directly to 16S ribosomal RNA (By similarity)
ACAN_0245	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
ACAN_0246	ENOG410813J	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
ACAN_0247	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
ACAN_0248	ENOG41080AZ	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
ACAN_0252	ENOG4107QY8	reductase
ACAN_0253	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
ACAN_0257	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
ACAN_0258	ENOG41084M8	50s ribosomal protein L35
ACAN_0259	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
ACAN_0266	ENOG4105KNE	Phosphatidate cytidylyltransferase
ACAN_0267	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
ACAN_0271	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ACAN_0272	ENOG4108ZJT	translation initiation factor, Sui1
ACAN_0274	ENOG4108ENG	carbohydrate kinase, YjeF related protein
ACAN_0276	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
ACAN_0287	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ACAN_0294	ENOG4107QMH	DNA methylase
ACAN_0295	ENOG4107J0C	type IIi
ACAN_0296	ENOG4108HFV	
ACAN_0316	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
ACAN_0318	ENOG4105SCY	DNAK suppressor
ACAN_0319	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
ACAN_0321	ENOG4107PE3	Mammalian cell entry related domain protein
ACAN_0322	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ACAN_0324	ENOG4108TX7	
ACAN_0326	ENOG4105CN1	protease
ACAN_0327	ENOG4105C8V	SAICAR synthetase
ACAN_0328	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
ACAN_0329	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
ACAN_0331	ENOG4105E9Q	Acyl-transferase
ACAN_0332	ENOG4105WMR	Protein CrcB homolog
ACAN_0334	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
ACAN_0335	ENOG4105C75	arginyL-tRNA synthetase
ACAN_0337	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
ACAN_0339	ENOG4105BZA	Phosphoglycerate kinase
ACAN_0340	ENOG4105CP7	Triose-phosphate isomerase
ACAN_0341	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
ACAN_0342	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
ACAN_0343	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
ACAN_0344	ENOG4105CQC	Prephenate dehydratase
ACAN_0345	ENOG4105CIH	Imidazole acetol-phosphate transaminase
ACAN_0346	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
ACAN_0349	ENOG4107YJQ	MAF-like protein
ACAN_0354	ENOG4107TT5	NLP P60 protein
ACAN_0356	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
ACAN_0358	ENOG4105BZU	Histidine kinase
ACAN_0359	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
ACAN_0360	ENOG4105BZG	amino acid carrier protein
ACAN_0361	ENOG4105C3M	thioredoxin reductase
ACAN_0362	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
ACAN_0364	ENOG4105N5T	Radical SAM Protein
ACAN_0365	ENOG4105DUM	transcriptional regulator, lysR family
ACAN_0366	ENOG4105C4R	Atp-dependent dna helicase
ACAN_0367	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
ACAN_0368	ENOG4107Z7S	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
ACAN_0369	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
ACAN_0370	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
ACAN_0378	ENOG4105E0U	tyrosine-specific transport protein
ACAN_0379	ENOG4105YIC	Major outer membrane protein
ACAN_0380	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
ACAN_0382	ENOG4105YIC	Major outer membrane protein
ACAN_0384	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
ACAN_0386	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
ACAN_0389	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
ACAN_0391	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
ACAN_0393	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
ACAN_0394	ENOG4105MGB	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
ACAN_0395	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
ACAN_0396	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
ACAN_0400	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
ACAN_0401	ENOG4108JQ1	Dehydrogenase
ACAN_0402	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
ACAN_0403	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
ACAN_0404	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
ACAN_0405	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
ACAN_0406	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
ACAN_0408	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
ACAN_0409	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
ACAN_0410	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
ACAN_0411	ENOG4105CHR	reductase
ACAN_0414	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
ACAN_0415	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
ACAN_0417	ENOG4107YV6	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
ACAN_0420	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
ACAN_0422	ENOG4107QID	Threonine synthase
ACAN_0423	ENOG4105CAS	nag kinase
ACAN_0424	ENOG4105BZU	Histidine kinase
ACAN_0425	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
ACAN_0426	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0427	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
ACAN_0428	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0429	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
ACAN_0430	ENOG4105C7B	Threonine dehydratase
ACAN_0431	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
ACAN_0432	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
ACAN_0436	ENOG4105CHR	reductase
ACAN_0437	ENOG4107XM3	UPF0442 protein
ACAN_0438	ENOG4105DWK	Membrane
ACAN_0441	ENOG4105BZU	Histidine kinase
ACAN_0443	ENOG4108VHG	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
ACAN_0444	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
ACAN_0447	ENOG4105C31	Tryptophanyl-tRNA synthetase
ACAN_0450	ENOG4105E5Q	amino acid AbC transporter
ACAN_0451	ENOG4105EAB	amino acid AbC transporter
ACAN_0452	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
ACAN_0454	ENOG4105EYM	Major Facilitator superfamily
ACAN_0455	ENOG4105BZ1	(ABC) transporter
ACAN_0456	ENOG4105BZ1	(ABC) transporter
ACAN_0457	ENOG4107ZSV	Receptor
ACAN_0459	ENOG4107ZSV	Receptor
ACAN_0461	ENOG4105X58	receptor
ACAN_0462	ENOG41074H6	response regulator
ACAN_0466	ENOG4109015	Biopolymer transport protein exbD tolR
ACAN_0473	ENOG4105E0K	tonB-dependent siderophore receptor
ACAN_0475	ENOG4105E0K	tonB-dependent siderophore receptor
ACAN_0476	ENOG4105EZV	Transcriptional regulator
ACAN_0478	ENOG4105CNM	Receptor
ACAN_0479	ENOG4107VQW	regulatoR
ACAN_0480	ENOG4105BZU	Histidine kinase
ACAN_0484	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
ACAN_0485	ENOG4105CRE	cytochrome C
ACAN_0486	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
ACAN_0487	ENOG4108W6G	cytochrome C
ACAN_0489	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
ACAN_0493	ENOG4108ZMS	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity)
ACAN_0494	ENOG4105GXZ	Ferredoxin-type protein NapH
ACAN_0495	ENOG4108BGM	Quinol dehydrogenase periplasmic component
ACAN_0496	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
ACAN_0497	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
ACAN_0500	ENOG4108I0Q	anthranilate phosphoribosyltransferase
ACAN_0502	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ACAN_0504	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
ACAN_0506	ENOG4108KA0	Inherit from COG: Phosphoesterase, DHHA1
ACAN_0508	ENOG4105D5U	fad dependent oxidoreductase
ACAN_0511	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
ACAN_0519	ENOG4105DHQ	Histidine kinase
ACAN_0520	ENOG4105ETX	regulatoR
ACAN_0521	ENOG4105EIN	peptidylprolyl cis-trans isomerase
ACAN_0522	ENOG4105D2N	Aldolase
ACAN_0524	ENOG4105E0F	Histidine kinase
ACAN_0526	ENOG4106GFD	transport protein
ACAN_0530	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
ACAN_0531	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
ACAN_0534	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
ACAN_0535	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ACAN_0537	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
ACAN_0540	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
ACAN_0541	ENOG4105VIE	preprotein translocase, subunit YajC
ACAN_0542	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ACAN_0543	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ACAN_0547	ENOG4105C8T	Leucyl-tRNA synthetase
ACAN_0549	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
ACAN_0550	ENOG4105DR5	peptidase
ACAN_0556	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ACAN_0557	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ACAN_0558	ENOG4105D05	Receptor
ACAN_0562	ENOG41074H6	response regulator
ACAN_0567	ENOG4108JA2	transcriptioN-repair coupling factor
ACAN_0571	ENOG4107EFR	Flavocytochrome c
ACAN_0572	ENOG4105BZU	Histidine kinase
ACAN_0573	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_0575	ENOG4107S7U	Sulfide dehydrogenase
ACAN_0577	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_0578	ENOG4105DHQ	Histidine kinase
ACAN_0579	ENOG4105CBX	hi0933 family
ACAN_0580	ENOG4105D48	metallophosphoesterase
ACAN_0584	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
ACAN_0585	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
ACAN_0586	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0587	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
ACAN_0588	ENOG4108V3W	Chemotaxis protein, CheW
ACAN_0590	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
ACAN_0591	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
ACAN_0593	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
ACAN_0594	ENOG41084FT	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
ACAN_0596	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
ACAN_0597	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
ACAN_0600	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
ACAN_0602	ENOG4105ECY	inositol monophosphatase
ACAN_0603	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
ACAN_0604	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
ACAN_0605	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
ACAN_0606	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
ACAN_0607	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
ACAN_0610	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
ACAN_0611	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
ACAN_0612	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ACAN_0614	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
ACAN_0615	ENOG4105ETX	regulatoR
ACAN_0618	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
ACAN_0619	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
ACAN_0624	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
ACAN_0626	ENOG4108RZE	Tetr family transcriptional regulator
ACAN_0627	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
ACAN_0629	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
ACAN_0630	ENOG4105ECP	epimerase
ACAN_0631	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
ACAN_0634	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
ACAN_0635	ENOG4105CDV	Ompa motb domain protein
ACAN_0636	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
ACAN_0637	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
ACAN_0638	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
ACAN_0639	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACAN_0640	ENOG4105DC7	peptidase M24
ACAN_0641	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
ACAN_0642	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
ACAN_0644	ENOG4105C1J	atp-dependent rna helicase
ACAN_0645	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
ACAN_0646	ENOG4108IJ2	phosphate acetyltransferase
ACAN_0647	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
ACAN_0648	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
ACAN_0650	ENOG4107QN1	sodium solute
ACAN_0652	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
ACAN_0654	ENOG4107QN1	sodium solute
ACAN_0656	ENOG4108STX	response regulator
ACAN_0670	ENOG4105CEV	competence damage-inducible protein
ACAN_0671	ENOG4107RSR	Malate quinone oxidoreductase
ACAN_0672	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
ACAN_0675	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
ACAN_0680	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ACAN_0681	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
ACAN_0682	ENOG4105CE9	30S ribosomal protein S2
ACAN_0683	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
ACAN_0684	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
ACAN_0686	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
ACAN_0687	ENOG4105BZU	Histidine kinase
ACAN_0688	ENOG4105HDK	L-asparaginase
ACAN_0689	ENOG4105C59	p-type ATPase
ACAN_0692	ENOG4105BZ1	(ABC) transporter
ACAN_0693	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
ACAN_0695	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
ACAN_0696	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
ACAN_0697	ENOG4107S90	membrAne
ACAN_0698	ENOG4105FDK	ABC transporter
ACAN_0700	ENOG4105QNR	S1 RNA binding domain protein
ACAN_0701	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
ACAN_0703	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
ACAN_0704	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
ACAN_0705	ENOG4108ETT	Dehydrogenase
ACAN_0711	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
ACAN_0713	ENOG4105ENA	helicase
ACAN_0714	ENOG4105BZU	Histidine kinase
ACAN_0715	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
ACAN_0729	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
ACAN_0734	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
ACAN_0735	ENOG4105BZS	acriflavin resistance protein
ACAN_0739	ENOG4107RDB	Major Facilitator
ACAN_0740	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
ACAN_0745	ENOG410901F	(LipO)protein
ACAN_0746	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
ACAN_0749	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
ACAN_0752	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
ACAN_0753	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0754	ENOG4105C59	p-type ATPase
ACAN_0758	ENOG4105D3R	alkyl hydroperoxide reductase
ACAN_0759	ENOG4105CKW	Inner membrane protein yedI
ACAN_0762	ENOG4108RZA	ABC transporter
ACAN_0763	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ACAN_0764	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ACAN_0765	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
ACAN_0766	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
ACAN_0767	ENOG4105BZU	Histidine kinase
ACAN_0768	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0769	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0770	ENOG41084IH	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
ACAN_0777	ENOG4105CHR	reductase
ACAN_0781	ENOG4106AXJ	AraC family transcriptional regulator
ACAN_0783	ENOG4107XSR	periplasmic solute binding protein
ACAN_0784	ENOG4105D7X	high-affinity nickel-transporter
ACAN_0789	ENOG4105C28	cystathionine
ACAN_0790	ENOG4105N5T	Radical SAM Protein
ACAN_0791	ENOG4105CNG	UPF0061 protein
ACAN_0796	ENOG41067SE	Tetr family transcriptional regulator
ACAN_0801	ENOG4105VG1	fes assembly suf system protein
ACAN_0802	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
ACAN_0803	ENOG4105C9B	Cysteine desulfurase
ACAN_0804	ENOG4105JRK	feS assembly protein SufD
ACAN_0805	ENOG4105C3K	feS assembly ATPase SufC
ACAN_0807	ENOG4105E5Q	amino acid AbC transporter
ACAN_0808	ENOG4105EAB	amino acid AbC transporter
ACAN_0809	ENOG4105C3J	Cysteine desulfurase
ACAN_0810	ENOG4107RIU	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity)
ACAN_0812	ENOG4105FQT	
ACAN_0814	ENOG4105CH7	arginosuccinase
ACAN_0815	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_0816	ENOG4105CUZ	uba thif-type nad fad binding protein
ACAN_0817	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
ACAN_0818	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
ACAN_0821	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
ACAN_0822	ENOG4105F8J	Adenylate Guanylate cyclase
ACAN_0824	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
ACAN_0825	ENOG4105CSM	endonuclease III
ACAN_0832	ENOG4108YZG	isomerase
ACAN_0833	ENOG4105C3F	Signal peptidase i
ACAN_0834	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
ACAN_0836	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
ACAN_0837	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
ACAN_0840	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
ACAN_0842	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
ACAN_0843	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
ACAN_0844	ENOG410692R	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
ACAN_0845	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
ACAN_0848	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
ACAN_0849	ENOG4105CRQ	synthase (Component I)
ACAN_0851	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
ACAN_0852	ENOG4105CRK	lysyL-tRNA synthetase
ACAN_0855	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
ACAN_0856	ENOG4105CDU	Replicative dna helicase
ACAN_0857	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
ACAN_0858	ENOG4107QP8	phosphohexose isomerase
ACAN_0863	ENOG41090HT	Inherit from COG: transposase
ACAN_0865	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
ACAN_0866	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
ACAN_0867	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
ACAN_0869	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
ACAN_0871	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
ACAN_0874	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
ACAN_0877	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
ACAN_0878	ENOG4107WZ3	Transferase
ACAN_0879	ENOG4108Z7G	MaoC domain protein dehydratase
ACAN_0881	ENOG4105D2T	synthase
ACAN_0885	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
ACAN_0889	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
ACAN_0890	ENOG4105CPQ	Dehydrogenase
ACAN_0897	ENOG4105K4U	addiction module toxin, RelE StbE family
ACAN_0898	ENOG4105VTW	prevent-host-death family
ACAN_0899	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
ACAN_0900	ENOG4105ESV	Glycosyl transferase, family 4
ACAN_0901	ENOG4105C5E	polysaccharide biosynthesis protein
ACAN_0902	ENOG4105C3G	gtp-binding protein
ACAN_0906	ENOG4105NBK	UPF0345 protein
ACAN_0910	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
ACAN_0911	ENOG4105S10	periplasmic binding protein
ACAN_0912	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ACAN_0914	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
ACAN_0918	ENOG4105FA0	parb-like partition protein
ACAN_0923	ENOG41067QW	Transcriptional regulator
ACAN_0961	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
ACAN_0962	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
ACAN_0964	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_0965	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
ACAN_0966	ENOG4105CPF	Cell wall formation (By similarity)
ACAN_0968	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
ACAN_0971	ENOG4105C8U	phosphate abc transporter
ACAN_0972	ENOG4105E2Z	phosphate ABC transporter (Permease
ACAN_0973	ENOG4108UMY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
ACAN_0975	ENOG4107QMZ	Dehydrogenase
ACAN_0978	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
ACAN_0979	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
ACAN_0980	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
ACAN_0981	ENOG4105KZZ	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
ACAN_0982	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACAN_0983	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
ACAN_0984	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
ACAN_0985	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
ACAN_0986	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
ACAN_0987	ENOG41084HJ	50s ribosomal protein l29
ACAN_0988	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
ACAN_0989	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
ACAN_0990	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
ACAN_0991	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACAN_0992	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
ACAN_0993	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
ACAN_0994	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
ACAN_0995	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
ACAN_0996	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
ACAN_0997	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
ACAN_0998	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
ACAN_0999	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
ACAN_1000	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
ACAN_1001	ENOG4106TD9	Diguanylate cyclase
ACAN_1003	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
ACAN_1005	ENOG4105C9M	aspartyl-trna synthetase
ACAN_1008	ENOG4105CCT	upf0313 protein
ACAN_1009	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
ACAN_1010	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
ACAN_1013	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
ACAN_1014	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
ACAN_1016	ENOG4108KN0	Choline kinase
ACAN_1017	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
ACAN_1021	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ACAN_1022	ENOG4105DAA	L-lactate
ACAN_1023	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
ACAN_1024	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ACAN_1027	ENOG4105VFU	Rna-binding protein
ACAN_1028	ENOG4105CGK	Exodeoxyribonuclease III
ACAN_1033	ENOG4106PMH	Extracellular solute-binding protein family 3
ACAN_1034	ENOG4105E5Q	amino acid AbC transporter
ACAN_1037	ENOG41090A1	ferritin
ACAN_1038	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
ACAN_1041	ENOG4105CYW	agmatinase
ACAN_1045	ENOG4108Z66	YbaK ebsC protein
ACAN_1046	ENOG4105C7I	Dehydrogenase
ACAN_1050	ENOG4105CGD	Nad-dependent epimerase dehydratase
ACAN_1054	ENOG4105BZU	Histidine kinase
ACAN_1055	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
ACAN_1060	ENOG4105SKE	transcriptional Regulator LysR family
ACAN_1062	ENOG4105Y49	secretion protein, HlyD family
ACAN_1063	ENOG4105ZQC	membrane protein AaeX
ACAN_1066	ENOG4105K56	Transcriptional regulator
ACAN_1071	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
ACAN_1072	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1073	ENOG4107VQW	regulatoR
ACAN_1074	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
ACAN_1076	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
ACAN_1077	ENOG4105E7W	lamb ycsf family protein
ACAN_1081	ENOG4105BZU	Histidine kinase
ACAN_1086	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ACAN_1088	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
ACAN_1094	ENOG4105CAY	ferredoxin--nadp reductase
ACAN_1095	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
ACAN_1096	ENOG4105BZU	Histidine kinase
ACAN_1097	ENOG4107R7Y	intracellular protease Pfpi family
ACAN_1099	ENOG4108JYZ	YitT family
ACAN_1102	ENOG4108M8H	domain protein
ACAN_1105	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAN_1107	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
ACAN_1108	ENOG4107B2H	carbonic anhydrase
ACAN_1124	ENOG4105BZU	Histidine kinase
ACAN_1125	ENOG4105BZU	Histidine kinase
ACAN_1126	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
ACAN_1127	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
ACAN_1130	ENOG4105BZU	Histidine kinase
ACAN_1135	ENOG4105DR5	peptidase
ACAN_1136	ENOG4105CDY	transcriptional regulatory protein
ACAN_1137	ENOG4105BZU	Histidine kinase
ACAN_1138	ENOG4105ERG	peptidase m48, ste24p
ACAN_1141	ENOG4107QPN	acyl-Coa dehydrogenase
ACAN_1142	ENOG4107QIJ	Aconitate hydratase 2
ACAN_1144	ENOG4105E3S	small subunit
ACAN_1146	ENOG4105E3S	small subunit
ACAN_1147	ENOG4105DPX	Hydrogenase, large subunit
ACAN_1148	ENOG4105X7T	Ni Fe-hydrogenase, b-type cytochrome subunit
ACAN_1149	ENOG4108USZ	hydrogenase
ACAN_1152	ENOG4105C8J	)-transporter
ACAN_1153	ENOG4105VCH	membrane
ACAN_1154	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1156	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
ACAN_1157	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
ACAN_1158	ENOG4105CQS	hydrogenase expression formation protein HypD
ACAN_1159	ENOG4105C45	hydrogenase expression formation protein (HypE)
ACAN_1160	ENOG4105F71	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
ACAN_1161	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
ACAN_1162	ENOG4105BZU	Histidine kinase
ACAN_1164	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
ACAN_1168	ENOG4105C25	Primosomal protein n'
ACAN_1169	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
ACAN_1170	ENOG4108YZY	peptidylprolyl cis-trans isomerase
ACAN_1174	ENOG4105CAK	Cell division ATP-binding protein ftsE
ACAN_1175	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
ACAN_1177	ENOG4105C34	Pseudouridine synthase
ACAN_1178	ENOG4105CNI	cell division protein FtsW
ACAN_1180	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
ACAN_1184	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
ACAN_1185	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
ACAN_1186	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
ACAN_1189	ENOG4105C94	Transporter
ACAN_1191	ENOG41067V7	50S ribosomal protein L36
ACAN_1192	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACAN_1193	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
ACAN_1194	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
ACAN_1195	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ACAN_1196	ENOG4108ZT0	50S ribosomal protein l17
ACAN_1197	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
ACAN_1198	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ACAN_1201	ENOG4105K5X	acetyltransferase
ACAN_1209	ENOG4108URH	decarboxylase
ACAN_1214	ENOG4105DWV	Homoserine O-trans-acetylase
ACAN_1216	ENOG4105W5Q	DNA repair protein (RadC
ACAN_1221	ENOG4105DZR	Type I site-specific deoxyribonuclease
ACAN_1222	ENOG4105D06	uba thif-type nad fad binding protein
ACAN_1223	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
ACAN_1228	ENOG4107RH8	nuclease SbcCD subunit D
ACAN_1229	ENOG4105EYH	Exonuclease
ACAN_1237	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
ACAN_1239	ENOG4105C6T	cysteine synthase
ACAN_1240	ENOG4105KME	endoribonuclease L-psp
ACAN_1242	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
ACAN_1243	ENOG4105CUX	Signal transduction histidine kinase
ACAN_1244	ENOG4105FS7	Transcriptional regulator
ACAN_1249	ENOG4108VYJ	response regulator receiver protein
ACAN_1250	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_1251	ENOG4108VYJ	response regulator receiver protein
ACAN_1252	ENOG4105CBS	Chea signal transduction histidine kinase
ACAN_1253	ENOG4107SDU	Methyl-accepting chemotaxis
ACAN_1254	ENOG4108V3W	Chemotaxis protein, CheW
ACAN_1255	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
ACAN_1257	ENOG4105BZU	Histidine kinase
ACAN_1260	ENOG4105D49	3-dehydroquinate synthase
ACAN_1262	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
ACAN_1263	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ACAN_1265	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
ACAN_1266	ENOG4105C8P	)-transporter
ACAN_1267	ENOG4105C98	muts2 protein
ACAN_1270	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ACAN_1274	ENOG4108HYG	acetyltransferase
ACAN_1277	ENOG41084DD	UPF0060 membrane protein
ACAN_1281	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
ACAN_1282	ENOG4108NKV	transcriptional regulator
ACAN_1289	ENOG4105KVH	Transcriptional regulator
ACAN_1290	ENOG4105NF4	modulator of drug activity
ACAN_1292	ENOG4108RCM	Nitroreductase
ACAN_1294	ENOG4108QDE	fad dependent oxidoreductase
ACAN_1295	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1296	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
ACAN_1303	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
ACAN_1304	ENOG4105BZU	Histidine kinase
ACAN_1305	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
ACAN_1306	ENOG4108PQF	modD protein
ACAN_1307	ENOG4105E0C	molybdate abc transporter
ACAN_1309	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
ACAN_1310	ENOG4105E0C	molybdate abc transporter
ACAN_1312	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
ACAN_1313	ENOG4105F4R	Transcriptional regulator mode
ACAN_1314	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
ACAN_1315	ENOG4105BZU	Histidine kinase
ACAN_1316	ENOG4105BZU	Histidine kinase
ACAN_1317	ENOG4105C5H	ABC transporter
ACAN_1320	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
ACAN_1321	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
ACAN_1322	ENOG4107XC4	flavin reductase domain protein, FMN-binding
ACAN_1323	ENOG4105C94	Transporter
ACAN_1324	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1325	ENOG4105C9Q	fumarate hydratase class II
ACAN_1329	ENOG4105DJG	MaoC domain protein dehydratase
ACAN_1330	ENOG4108ES0	acetoacetyl-CoA synthetase
ACAN_1333	ENOG4105CIN	aminoacyl-histidine dipeptidase
ACAN_1334	ENOG4105BZU	Histidine kinase
ACAN_1335	ENOG4105CRE	cytochrome C
ACAN_1336	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
ACAN_1338	ENOG4105BZU	Histidine kinase
ACAN_1340	ENOG4105ED9	Protein of unknown function (DUF455)
ACAN_1341	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
ACAN_1342	ENOG4105MFQ	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity)
ACAN_1343	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ACAN_1345	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
ACAN_1346	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1349	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
ACAN_1350	ENOG4105BZU	Histidine kinase
ACAN_1351	ENOG4105BZU	Histidine kinase
ACAN_1354	ENOG410874W	AraC family transcriptional regulator
ACAN_1361	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1362	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1363	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1365	ENOG4108WZ2	response regulator
ACAN_1371	ENOG4108Z0R	Transferase
ACAN_1376	ENOG4105CDH	Citrulline--aspartate ligase
ACAN_1378	ENOG4107QYG	anthranilate phosphoribosyltransferase
ACAN_1379	ENOG4105K8N	protein family UPF0079, ATPase
ACAN_1380	ENOG4108IUZ	ABC transporter
ACAN_1381	ENOG4105BZU	Histidine kinase
ACAN_1382	ENOG4105BZU	Histidine kinase
ACAN_1383	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
ACAN_1384	ENOG4105CQZ	Histidine kinase
ACAN_1385	ENOG4105C2M	dna polymerase I
ACAN_1386	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_1389	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
ACAN_1390	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
ACAN_1392	ENOG4105D4P	Coproporphyrinogen iii oxidase
ACAN_1393	ENOG4105DBV	ornithine carbamoyltransferase
ACAN_1398	ENOG4105D7Z	glutathione synthase
ACAN_1401	ENOG4105BZU	Histidine kinase
ACAN_1402	ENOG4105D52	delta-aminolevulinic acid dehydratase
ACAN_1403	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
ACAN_1404	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
ACAN_1415	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
ACAN_1416	ENOG4105D9Q	decarboxylase (Beta subunit)
ACAN_1421	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
ACAN_1423	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACAN_1428	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
ACAN_1430	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
ACAN_1431	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACAN_1433	ENOG4105EEI	dihydropteroate synthase
ACAN_1436	ENOG4105CFH	Aspartokinase
ACAN_1438	ENOG4105CSA	Coproporphyrinogen iii oxidase
ACAN_1439	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ACAN_1440	ENOG4105DGW	oligopeptidase A
ACAN_1443	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
ACAN_1450	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ACAN_1457	ENOG4108DT4	serine threonine protein kinase
ACAN_1458	ENOG4108WC9	type VI secretion system effector, hcp1 family
ACAN_1464	ENOG4108EU4	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ACAN_1465	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
ACAN_1466	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
ACAN_1467	ENOG4105BZU	Histidine kinase
ACAN_1468	ENOG4105CBS	Chea signal transduction histidine kinase
ACAN_1469	ENOG4108VYJ	response regulator receiver protein
ACAN_1470	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
ACAN_1472	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
ACAN_1474	ENOG4105C12	Phosphoribosylglycinamide synthetase
ACAN_1476	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
ACAN_1478	ENOG4105CNU	cell division protein FtsK
ACAN_1479	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
ACAN_1480	ENOG4108ZP8	Acetolactate synthase small subunit
ACAN_1481	ENOG4105C7K	acetolactate synthase
ACAN_1483	ENOG4105C9X	ppx gppa phosphatase
ACAN_1488	ENOG4105K63	Thioredoxin
ACAN_1490	ENOG4105EWC	Purine nucleoside phosphorylase
ACAN_1491	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
ACAN_1492	ENOG4105D3Y	Na H antiporter
ACAN_1494	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
ACAN_1497	ENOG4105C26	Dehydrogenase
ACAN_1498	ENOG4108IV0	ABC, transporter
ACAN_1499	ENOG4105C0Z	ABC transporter
ACAN_1500	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
ACAN_1501	ENOG4105C32	Amino acid ABC transporter (Permease)
ACAN_1506	ENOG4105CJZ	response regulator
ACAN_1508	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
ACAN_1510	ENOG4108ISG	Major Facilitator
ACAN_1511	ENOG4105CGY	Dna recombination protein
ACAN_1512	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
ACAN_1514	ENOG4105BZU	Histidine kinase
ACAN_1515	ENOG4107YD3	Thioesterase
ACAN_1518	ENOG4105CPC	Aldo Keto reductase
ACAN_1521	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
ACAN_1522	ENOG4105EHG	Permease protein
ACAN_1523	ENOG4108JJB	ABC transporter
ACAN_1524	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
ACAN_1525	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
ACAN_1531	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
ACAN_1532	ENOG41081F0	Precorrin-8x methylmutase
ACAN_1534	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
ACAN_1535	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
ACAN_1536	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
ACAN_1537	ENOG4108P62	biosynthesis protein (CbiG)
ACAN_1538	ENOG4105E4R	Precorrin-3B C17-methyltransferase
ACAN_1542	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ACAN_1545	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
ACAN_1549	ENOG4105M15	transport protein ExbD
ACAN_1550	ENOG4105M8K	biopolymer transport protein
ACAN_1551	ENOG4105BZU	Histidine kinase
ACAN_1552	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_1556	ENOG4105CIY	formyltetrahydrofolate deformylase
ACAN_1557	ENOG4105C6K	Malic enzyme
ACAN_1558	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
ACAN_1559	ENOG4105E2X	shikimate dehydrogenase
ACAN_1563	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
ACAN_1564	ENOG4108UHV	Lipoprotein
ACAN_1565	ENOG4106032	Glutathionylspermidine synthase
ACAN_1567	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
ACAN_1568	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
ACAN_1569	ENOG4105C4K	Nad synthetase
ACAN_1573	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
ACAN_1574	ENOG41084AD	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
ACAN_1575	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
ACAN_1576	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
ACAN_1577	ENOG4105UMD	exodeoxyribonuclease X
ACAN_1578	ENOG4105C8J	)-transporter
ACAN_1585	ENOG4105DJI	Methylaspartate mutase, E subunit
ACAN_1588	ENOG4105VBD	cytochrome C, class I
ACAN_1589	ENOG41064RH	membrane protein YliF
ACAN_1594	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
ACAN_1596	ENOG410841J	DNA-binding protein Hu
ACAN_1602	ENOG4108Z86	Glutamine amidotransferase
ACAN_1604	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
ACAN_1605	ENOG4108JPW	Aminotransferase
ACAN_1606	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
ACAN_1609	ENOG4105CFH	Aspartokinase
ACAN_1613	ENOG4105VBD	cytochrome C, class I
ACAN_1615	ENOG4105BZU	Histidine kinase
ACAN_1616	ENOG4108STX	response regulator
ACAN_1633	ENOG4105BZU	Histidine kinase
ACAN_1634	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
ACAN_1634	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
ACAN_1635	ENOG4105BZ1	(ABC) transporter
ACAN_1640	ENOG4105ZGC	lipoprotein carrier protein
ACAN_1641	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
ACAN_1645	ENOG4105E9K	Isocitrate dehydrogenase
ACAN_1647	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
ACAN_1649	ENOG4107YTP	response regulator receiver protein
ACAN_1652	ENOG4105DVC	DnaJ domain protein
ACAN_1653	ENOG4105KNI	merR family transcriptional Regulator
ACAN_1654	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
ACAN_1655	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
ACAN_1657	ENOG4105C7H	Helicase, RecD TraA family
ACAN_1662	ENOG4105D00	flagellar biosynthetic protein flhB
ACAN_1664	ENOG4105CJN	penicillin-binding protein
ACAN_1665	ENOG4105CN7	Flagellar biosynthetic protein FliP
ACAN_1670	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAN_1671	ENOG4105KY5	gCN5-related N-acetyltransferase
ACAN_1672	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
ACAN_1675	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
ACAN_1676	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
ACAN_1677	ENOG4105K6T	rare lipoprotein A
ACAN_1679	ENOG4105F8V	Hydrolase, tatD family
ACAN_1682	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
ACAN_1683	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
ACAN_1685	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
ACAN_1686	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
ACAN_1687	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
ACAN_1688	ENOG4105CUT	histidyl-tRNA synthetase
ACAN_1689	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
ACAN_1690	ENOG4105D7W	serine acetyltransferase
ACAN_1692	ENOG4105CH2	amidohydrolase
ACAN_1693	ENOG4108JPW	Aminotransferase
ACAN_1695	ENOG4105ENR	peptidase, M24
ACAN_1697	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
ACAN_1699	ENOG4105CK2	sodium dicarboxylate symporter
ACAN_1701	ENOG4108JU6	CBS domain protein
ACAN_1702	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
ACAN_1704	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
ACAN_1705	ENOG4108V06	Glutathione peroxidase
ACAN_1711	ENOG4105D01	(LipO)protein
ACAN_1712	ENOG4108UMI	ABC transporter, permease
ACAN_1713	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ACAN_1714	ENOG4105FCD	Major Facilitator
ACAN_1715	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
ACAN_1716	ENOG4105DR4	Methyltransferase
ACAN_1717	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
ACAN_1720	ENOG4105CHH	sulfate transporter
ACAN_1722	ENOG4107QN2	dihydrolipoyl dehydrogenase
ACAN_1723	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
ACAN_1724	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
ACAN_1726	ENOG4105PW4	Sugar fermentation stimulation protein homolog
ACAN_1730	ENOG4105CQ7	ATP-dependent helicase
ACAN_1731	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
ACAN_1737	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
ACAN_1742	ENOG4105VEQ	Cold shock protein
ACAN_1745	ENOG4105C1J	atp-dependent rna helicase
ACAN_1746	ENOG4105FE9	pseudouridine synthase
ACAN_1762	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
ACAN_1765	ENOG4108IYU	L-aspartate oxidase
ACAN_1768	ENOG4105CHM	Aminotransferase
ACAN_1769	ENOG41076HS	cation diffusion facilitator family transporter
ACAN_1770	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1771	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_1772	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
ACAN_1774	ENOG4107QN2	dihydrolipoyl dehydrogenase
ACAN_1775	ENOG4107QSN	dihydrolipoamide acetyltransferase
ACAN_1776	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
ACAN_1777	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
ACAN_1778	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
ACAN_1779	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
ACAN_1780	ENOG4105C5H	ABC transporter
ACAN_1781	ENOG4105KTH	gatB Yqey
ACAN_1782	ENOG4105BZU	Histidine kinase
ACAN_1785	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
ACAN_1788	ENOG4105KJM	monovalent cation h antiporter subunit g
ACAN_1789	ENOG4105W4C	monovalent cation H antiporter subunit F
ACAN_1790	ENOG4105SC1	monovalent cation H antiporter subunit E
ACAN_1791	ENOG4107R4Z	monovalent cation h antiporter subunit d
ACAN_1792	ENOG4108ZE9	Monovalent cation H antiporter subunit C
ACAN_1793	ENOG4105D65	subunit l
ACAN_1794	ENOG4105E1F	short-chain dehydrogenase reductase
ACAN_1795	ENOG4107S6Z	Na H antiporter
ACAN_1796	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ACAN_1797	ENOG4106H78	methyltransferase
ACAN_1798	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
ACAN_1799	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
ACAN_1801	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
ACAN_1803	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAN_1804	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
ACAN_1807	ENOG4105BZU	Histidine kinase
ACAN_1808	ENOG4105NQN	cytochrome C
ACAN_1809	ENOG4105IPS	esterase
ACAN_1812	ENOG4108QAF	Methyl-accepting chemotaxis sensory transducer
ACAN_1813	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
ACAN_1816	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
ACAN_1819	ENOG4108RMU	ferritin dps family protein
ACAN_1820	ENOG4108RAC	Rubrerythrin
ACAN_1823	ENOG4105CJR	Integral membrane protein (MviN
ACAN_1824	ENOG4105BZ1	(ABC) transporter
ACAN_1825	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
ACAN_1827	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
ACAN_1828	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
ACAN_1829	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
ACAN_1830	ENOG4105DZP	Membrane-associated zinc metalloprotease
ACAN_1831	ENOG4105DFA	alanine racemase domain protein
ACAN_1835	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
ACAN_1836	ENOG4105DK0	Indole-3-glycerol phosphate synthase
ACAN_1838	ENOG4105QTX	Pfam:UPF0153
ACAN_1839	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
ACAN_1841	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
ACAN_1842	ENOG4105C7K	acetolactate synthase
ACAN_1844	ENOG4105KPY	Small multidrug resistance protein
ACAN_1846	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
ACAN_1847	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
ACAN_1848	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
ACAN_1849	ENOG4105DJV	ribulose-phosphate 3-epimerase
ACAN_1850	ENOG4105DY2	Paraquat-inducible protein b
ACAN_1851	ENOG4105H2K	paraquat-inducible protein a
ACAN_1852	ENOG4105F1S	paraquat-inducible protein a
ACAN_1853	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
ACAN_1856	ENOG4105HDD	phospholipase
ACAN_1865	ENOG4105DAP	Nicotinate phosphoribosyltransferase
ACAN_1867	ENOG4105BZU	Histidine kinase
ACAN_1870	ENOG4107VIJ	nudix hydrolase
ACAN_1873	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_1874	ENOG4105HMI	Membrane
ACAN_1875	ENOG4105DUM	transcriptional regulator, lysR family
ACAN_1877	ENOG4108VPT	UPF0234 protein
ACAN_1880	ENOG4105C2W	permease
ACAN_1881	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
ACAN_1883	ENOG4105M08	Membrane
ACAN_1885	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
ACAN_1886	ENOG4105C7N	Xanthine uracil vitamin C permease
ACAN_1888	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
ACAN_1889	ENOG4108BRW	Activates expression of the rhaSR operon in response to L-rhamnose (By similarity)
ACAN_1890	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
ACAN_1892	ENOG4105C59	p-type ATPase
ACAN_1893	ENOG4105E0K	tonB-dependent siderophore receptor
ACAN_1896	ENOG4108I6A	alcohol dehydrogenase
ACAN_1898	ENOG4105XFK	Ferrous iron transport protein A
ACAN_1899	ENOG4105CE1	Ferrous iron transport protein b
ACAN_1904	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
ACAN_1925	ENOG4105ED4	portal protein
ACAN_1952	ENOG41082XB	radical SAM domain protein
ACAN_1953	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
ACAN_1955	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
ACAN_1958	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
ACAN_1960	ENOG4105VB9	50S ribosomal protein l28
ACAN_1962	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
ACAN_1963	ENOG4105DKP	glycosyl transferase, family 9
ACAN_1965	ENOG4108NIH	transferase activity, transferring phosphorus-containing groups
ACAN_1966	ENOG4105M5K	heptosyltransferase
ACAN_1968	ENOG4108I6E	Sulfatase
ACAN_1970	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ACAN_1971	ENOG4106WTF	Glycosyl transferase, family 2
ACAN_1978	ENOG41080IJ	Diacylglycerol kinase
ACAN_1980	ENOG4105DKP	glycosyl transferase, family 9
ACAN_1982	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
ACAN_1984	ENOG4105BZ8	glutamate synthase
ACAN_1985	ENOG4105CBC	glutamate synthase
ACAN_1986	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
ACAN_1988	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
ACAN_1993	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
ACAN_1996	ENOG4105VSH	4-oxalocrotonate tautomerase
ACAN_1998	ENOG4105EGI	Transcriptional regulator
ACAN_2003	ENOG4105D17	glycoside hydrolase, family 3 domain protein
ACAN_2004	ENOG4108QD1	Membrane
ACAN_2006	ENOG4105TMB	Formate nitrite transporter
ACAN_2009	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
ACAN_2011	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2012	ENOG4108JPZ	Monovalent cation H antiporter subunit D
ACAN_2013	ENOG4107WQX	hydrogenase 4 membrane subunit
ACAN_2014	ENOG4107TDF	Formate hydrogenlyase subunit 4
ACAN_2015	ENOG4108JPZ	Monovalent cation H antiporter subunit D
ACAN_2016	ENOG4108MFN	small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex)
ACAN_2020	ENOG4107Z6A	sulfate abc transporter permease
ACAN_2021	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
ACAN_2022	ENOG41066FR	extracellular solute-binding protein
ACAN_2024	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
ACAN_2025	ENOG4105C8W	ABC transporter
ACAN_2026	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
ACAN_2027	ENOG4107QI6	Cysteine desulfurase
ACAN_2028	ENOG4105F4R	Transcriptional regulator mode
ACAN_2030	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
ACAN_2032	ENOG4105QAX	Iron-sulfur
ACAN_2039	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
ACAN_2042	ENOG4108KS2	transglutaminase domain protein
ACAN_2045	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
ACAN_2046	ENOG4105EM7	Selenocysteine-specific translation elongation factor
ACAN_2048	ENOG4108IAB	Phoh family
ACAN_2051	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
ACAN_2052	ENOG4108K1J	Transporter DctQ
ACAN_2053	ENOG4108KJ1	Trap dicarboxylate transporter, dctp subunit
ACAN_2054	ENOG4105CA0	peroxidase
ACAN_2055	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_2056	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
ACAN_2058	ENOG4105C1J	atp-dependent rna helicase
ACAN_2060	ENOG4105EYH	Exonuclease
ACAN_2068	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
ACAN_2069	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
ACAN_2070	ENOG4108YZY	peptidylprolyl cis-trans isomerase
ACAN_2073	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
ACAN_2075	ENOG4105M8F	Biopolymer transport protein exbD tolR
ACAN_2076	ENOG4105E02	MotA TolQ exbB proton channel
ACAN_2077	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
ACAN_2078	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
ACAN_2079	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
ACAN_2080	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
ACAN_2081	ENOG4105PQH	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
ACAN_2082	ENOG4105YF2	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
ACAN_2084	ENOG4105FA0	parb-like partition protein
ACAN_2085	ENOG4107QJE	Chromosome Partitioning Protein
ACAN_2088	ENOG4105BZU	Histidine kinase
ACAN_2089	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
ACAN_2090	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
ACAN_2091	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACAN_2092	ENOG4105K46	50S ribosomal protein l27
ACAN_2093	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
ACAN_2094	ENOG4105KME	endoribonuclease L-psp
ACAN_2095	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
ACAN_2097	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
ACAN_2098	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
ACAN_2099	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
ACAN_2101	ENOG4105VYW	UPF0251 protein
ACAN_2102	ENOG4105D0M	Protease HtpX homolog
ACAN_2105	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
ACAN_2107	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
ACAN_2108	ENOG4108512	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
ACAN_2110	ENOG4105VG0	50S ribosomal protein l34
ACAN_2111	ENOG4105CQZ	Histidine kinase
ACAN_2112	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ACAN_2113	ENOG4105BZU	Histidine kinase
ACAN_2115	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
ACAN_2118	ENOG4105BZU	Histidine kinase
ACAN_2120	ENOG4105E0X	reductase
ACAN_2121	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
ACAN_2123	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
ACAN_2126	ENOG4105C6Z	Gluconate
ACAN_2129	ENOG4105D3R	alkyl hydroperoxide reductase
ACAN_2130	ENOG4105C7K	acetolactate synthase
ACAN_2134	ENOG4105BZU	Histidine kinase
ACAN_2136	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
ACAN_2138	ENOG4108RR8	protoporphyrinogen oxidase
ACAN_2142	ENOG4105DC1	bifunctional purine biosynthesis protein purh
ACAN_2143	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
ACAN_2145	ENOG4105E4C	Lytic transglycosylase catalytic
ACAN_2146	ENOG4105CJW	magnesium transporter
ACAN_2148	ENOG4105C94	Transporter
ACAN_2149	ENOG4105EUJ	GTP cyclohydrolase i
ACAN_2151	ENOG4107QHF	type ii secretion system protein e
ACAN_2154	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
ACAN_2159	ENOG4105DY9	regulatoR
ACAN_2160	ENOG4108HRK	Histidine kinase
ACAN_2161	ENOG4105EWK	phytoene
ACAN_2162	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
ACAN_2164	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
ACAN_2165	ENOG4105C0P	Mg chelatase subunit ChlI
ACAN_2166	ENOG4107SDU	Methyl-accepting chemotaxis
ACAN_2167	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_2169	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ACAN_2170	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ACAN_2171	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
ACAN_2175	ENOG4105CSR	polyphosphate kinase 2
ACAN_2176	ENOG4105CSR	polyphosphate kinase 2
ACAN_2178	ENOG4105VCQ	rubredoxin
ACAN_2183	ENOG4105CSA	Coproporphyrinogen iii oxidase
ACAN_2185	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_2187	ENOG4105D64	Mechanosensitive ion channel
ACAN_2190	ENOG4105C4M	(Ubiquinol oxidase) subunit I
ACAN_2192	ENOG4105VYW	UPF0251 protein
ACAN_2200	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
ACAN_2201	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
ACAN_2202	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
ACAN_2211	ENOG4105BZU	Histidine kinase
ACAN_2213	ENOG4105CE1	Ferrous iron transport protein b
ACAN_2218	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
ACAN_2219	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
ACAN_2220	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
ACAN_2221	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
ACAN_2222	ENOG4105F4G	Membrane
ACAN_2226	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
ACAN_2234	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
ACAN_2235	ENOG4105I03	Flagellin
ACAN_2235	ENOG4105I03	Flagellin
ACAN_2237	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ACAN_2238	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
ACAN_2239	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
ACAN_2242	ENOG4105CRU	nitrate reductase, alpha subunit
ACAN_2245	ENOG4105D7B	Flagellar biosynthesis protein flha
ACAN_2247	ENOG4108JIR	Flagellum-specific ATP synthase
ACAN_2249	ENOG4105D00	flagellar biosynthetic protein flhB
ACAN_2252	ENOG4108ZC9	flagellar basal-body rod protein flgc
ACAN_2253	ENOG41084DA	flagellar hook-basal body complex protein fliE
ACAN_2255	ENOG4107R21	site-determining protein
ACAN_2256	ENOG4105FZW	flagellar biosynthesis regulator FlhF
ACAN_2261	ENOG4108217	motA TolQ ExbB proton channel
ACAN_2262	ENOG4105DD5	Flagellar motor switch protein
ACAN_2266	ENOG4105BZE	flagellar hook protein, FlgE
ACAN_2267	ENOG4105BZE	flagellar hook protein, FlgE
ACAN_2269	ENOG4105DD5	Flagellar motor switch protein
ACAN_2271	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
ACAN_2272	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
ACAN_2273	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
ACAN_2274	ENOG4105CGA	flagellar basal-body rod protein FlgG
ACAN_2277	ENOG4105CGA	flagellar basal-body rod protein FlgG
ACAN_2280	ENOG4105V3S	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
ACAN_2281	ENOG4105VB6	UPF0109 protein
ACAN_2282	ENOG4105K5M	30s ribosomal protein S16
ACAN_2283	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACAN_2284	ENOG4105C34	Pseudouridine synthase
ACAN_2285	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
ACAN_2287	ENOG4105EGD	dinuclear metal center protein, YbgI family
ACAN_2288	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
ACAN_2289	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
ACAN_2291	ENOG4105CFP	Peptidase U32
ACAN_2292	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
ACAN_2292	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
ACAN_2294	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
ACAN_2295	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
ACAN_2296	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
ACAN_2297	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
ACAN_2298	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
ACAN_2299	ENOG4105F27	Major Facilitator
ACAN_2303	ENOG4108UPT	UPF0178 protein
ACAN_2314	ENOG4105BZU	Histidine kinase
ACAN_2315	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_2317	ENOG4108J2R	molybdopterin oxidoreductase
ACAN_2318	ENOG4107ZT3	family UPF0126
ACAN_2324	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ACAN_2325	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ACAN_2326	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
ACAN_2327	ENOG4108VZM	50s ribosomal protein L10
ACAN_2328	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
ACAN_2329	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
ACAN_2330	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
ACAN_2333	ENOG41086AR	50S ribosomal protein L33
ACAN_2334	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
ACAN_2339	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
ACAN_2340	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
ACAN_2341	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
ACAN_2343	ENOG4108JQ5	ABC transporter
ACAN_2344	ENOG4108JQC	penicillin-binding protein 1A
ACAN_2345	ENOG4105C5F	glutamine synthetase
ACAN_2346	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
ACAN_2347	ENOG4105BZU	Histidine kinase
ACAN_2348	ENOG4108ZEX	molybdopterin converting factor, subunit 2
ACAN_2350	ENOG4108XUR	Pfam:DUF178
ACAN_2351	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
ACAN_2353	ENOG4105CNI	cell division protein FtsW
ACAN_2354	ENOG4105CJN	penicillin-binding protein
ACAN_2355	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
ACAN_2364	ENOG4105DDQ	anthranilate synthase
ACAN_2368	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
ACAN_2369	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
ACAN_2370	ENOG4105C87	Aminotransferase class I and II
ACAN_2371	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ACAN_2372	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2373	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2376	ENOG4105BZN	citrate synthase
ACAN_2378	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
ACAN_2380	ENOG4107UFS	subunit j
ACAN_2381	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2382	ENOG4105D65	subunit l
ACAN_2383	ENOG4105C8S	subunit m
ACAN_2384	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2385	ENOG4108S24	Fumarate reduCtase
ACAN_2386	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
ACAN_2387	ENOG4105E33	succinate dehydrogenase
ACAN_2389	ENOG410890F	Dynamin family
ACAN_2390	ENOG4105BZW	Glycerate kinase
ACAN_2393	ENOG4107R4J	Chloride channel
ACAN_2395	ENOG4105C7K	acetolactate synthase
ACAN_2396	ENOG4105C26	Dehydrogenase
ACAN_2399	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
ACAN_2403	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
ACAN_2404	ENOG4105EAD	ABC transporter
ACAN_2405	ENOG4106PMH	Extracellular solute-binding protein family 3
ACAN_2408	ENOG4108BSC	Methyltransferase
ACAN_2409	ENOG4105C09	Bile acid
ACAN_2410	ENOG4108W2Y	isochorismatase
ACAN_2412	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
ACAN_2413	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
ACAN_2414	ENOG4105C9U	ATP-dependent DNA helicase RecQ
ACAN_2417	ENOG4105CR4	methylisocitrate lyase
ACAN_2418	ENOG4105BZN	citrate synthase
ACAN_2419	ENOG4108I0Z	Aconitate hydratase
ACAN_2420	ENOG4105C7F	AcnD-accessory protein PrpF
ACAN_2422	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
ACAN_2424	ENOG4107QMP	dna polymerase iii subunits gamma and tau
ACAN_2425	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
ACAN_2428	ENOG41074H6	response regulator
ACAN_2429	ENOG4107RBR	Receptor
ACAN_2430	ENOG4105E93	esterase
ACAN_2431	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
ACAN_2432	ENOG4105D3R	alkyl hydroperoxide reductase
ACAN_2434	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
ACAN_2436	ENOG4105YQ2	50s ribosomal protein l32
ACAN_2437	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
ACAN_2438	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
ACAN_2440	ENOG4105KMT	branched-chain amino acid
ACAN_2441	ENOG4108UMN	azlc family
ACAN_2448	ENOG4105CXT	aspartate transcarbamylase
ACAN_2449	ENOG4105C8Y	Acetylornithine aminotransferase
ACAN_2452	ENOG4105CA9	Pyruvate kinase
ACAN_2456	ENOG4105BZU	Histidine kinase
ACAN_2457	ENOG4108STX	response regulator
ACAN_2459	ENOG41082UM	UPF0102 protein
ACAN_2460	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_2461	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
ACAN_2463	ENOG4107B2H	carbonic anhydrase
ACAN_2465	ENOG4105DVY	radical SAM domain protein
ACAN_2467	ENOG4105KB8	(LipO)protein
ACAN_2468	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
ACAN_2470	ENOG4105CHV	Transcription elongation factor NusA
ACAN_2471	ENOG4105C8N	cysteinyl-tRNA synthetase
ACAN_2472	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
ACAN_2473	ENOG4108UUM	single-stranded DNA-binding protein
ACAN_2474	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
ACAN_2475	ENOG4108VMB	DNA polymerase III subunit delta'
ACAN_2476	ENOG4105PS2	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
ACAN_2477	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
ACAN_2479	ENOG4105BZU	Histidine kinase
ACAN_2480	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
ACAN_2492	ENOG41085FC	arsR family transcriptional regulator
ACAN_2496	ENOG4105D5G	Transposase
ACAN_2506	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ACAN_2510	ENOG4105BZU	Histidine kinase
ACAN_2511	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_2512	ENOG4105DVI	reductase, NrfD
ACAN_2513	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
ACAN_2514	ENOG4108J2R	molybdopterin oxidoreductase
ACAN_2515	ENOG4105DFU	Cell wall formation (By similarity)
ACAN_2517	ENOG4105CHM	Aminotransferase
ACAN_2519	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
ACAN_2520	ENOG410855J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ACAN_2521	ENOG4105KUZ	arsenate reductase
ACAN_2522	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
ACAN_2524	ENOG4105EAC	phosphoserine phosphatase
ACAN_2526	ENOG4105GSH	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
ACAN_2527	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
ACAN_2529	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
ACAN_2530	ENOG4108VYJ	response regulator receiver protein
ACAN_2531	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
ACAN_2535	ENOG4107TPX	flagellar hook-associated
ACAN_2536	ENOG4105E1Q	flagellar hook-associated protein
ACAN_2542	ENOG4105VS8	Flagellar biosynthetic protein fliq
ACAN_2544	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
ACAN_2545	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
ACAN_2546	ENOG4105EKE	dihydroorotase
ACAN_2547	ENOG4108YZA	Nitrogen regulatory protein pii
ACAN_2549	ENOG4108YZA	Nitrogen regulatory protein pii
ACAN_2554	ENOG4105CEY	Amp-dependent synthetase and ligase
ACAN_2555	ENOG41085FC	arsR family transcriptional regulator
ACAN_2556	ENOG4107R5R	arsenical pump membrane protein
ACAN_2560	ENOG4105D7N	magnesium and cobalt transport protein CorA
ACAN_2561	ENOG4105CHH	sulfate transporter
ACAN_2563	ENOG4105FR1	rard protein
ACAN_2566	ENOG4108JU6	CBS domain protein
ACAN_2567	ENOG41067MG	lrgb family
ACAN_2568	ENOG4105VAW	lrga family
ACAN_2569	ENOG4108SGR	YheO domain-containing protein
ACAN_2571	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
ACAN_2572	ENOG4105BZU	Histidine kinase
ACAN_2573	ENOG4105HDK	L-asparaginase
ACAN_2574	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
ACAN_2575	ENOG4108IJ0	Aspartate ammonia-lyase
ACAN_2576	ENOG4105E33	succinate dehydrogenase
ACAN_2577	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
ACAN_2578	ENOG4108S24	Fumarate reduCtase
ACAN_2579	ENOG4105CV1	Transketolase (EC 2.2.1.1)
ACAN_2584	ENOG4107QZV	Type I secretion membrane fusion protein
ACAN_2585	ENOG4108JJA	ABC, transporter
ACAN_2588	ENOG4105DSF	transport protein
ACAN_2589	ENOG4108HGU	Histidine kinase
ACAN_2595	ENOG4105C01	Dihydroxy-acid dehydratase
ACAN_2596	ENOG4105C0H	protease
ACAN_2597	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
ACAN_2598	ENOG4105BZU	Histidine kinase
ACAN_2599	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
ACAN_2600	ENOG4105BZU	Histidine kinase
ACAN_2604	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
ACAN_2605	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
ACAN_2606	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
ACAN_2607	ENOG4105DFS	Conserved Protein
ACAN_2610	ENOG4105CIH	Imidazole acetol-phosphate transaminase
ACAN_2611	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
ACAN_2613	ENOG41081FY	multiple antibiotic resistance (MarC)-related
ACAN_2614	ENOG4108K7V	UPF0284 protein
ACAN_2619	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
ACAN_2626	ENOG4105HKU	nucleoside recognition domain-containing protein
ACAN_2627	ENOG4105CA3	membrane-bound lytic murein transglycosylase
ACAN_2629	ENOG4105CFG	Acts as a chaperone (By similarity)
ACAN_2630	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACAN_2631	ENOG4108122	heat-inducible transcription repressor
ACAN_2638	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ACAN_2640	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
ACAN_2642	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
ACAN_2643	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ACAN_2644	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
ACAN_2645	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
ACAN_2648	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
ACAN_2649	ENOG4105I03	Flagellin
ACAN_2651	ENOG4105I03	Flagellin
ACAN_2652	ENOG4105I03	Flagellin
ACAN_2653	ENOG4105I03	Flagellin
ACAN_2654	ENOG4105I03	Flagellin
ACAN_2655	ENOG4105I03	Flagellin
ACAN_2661	ENOG4107TY6	Acylneuraminate cytidylyltransferase
ACAN_2663	ENOG4105D2T	synthase
ACAN_2668	ENOG4107DKY	pseudaminic acid biosynthesis-associated protein PseG
ACAN_2669	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
ACAN_2671	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
ACAN_2672	ENOG4105C5E	polysaccharide biosynthesis protein
ACAN_2673	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
ACAN_2674	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
ACAN_2678	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
ACAN_2682	ENOG4105E63	Pfam:DUF178
ACAN_2684	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2685	ENOG4105C8S	subunit m
ACAN_2686	ENOG4105D65	subunit l
ACAN_2687	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2689	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2690	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
ACAN_2694	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2695	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ACAN_2696	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ACAN_2697	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ACAN_2698	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ACAN_2702	ENOG4105C5H	ABC transporter
ACAN_2703	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
ACAN_2705	ENOG4105BZU	Histidine kinase
ACAN_2707	ENOG4105WPN	DNA integration recombination invertion protein
ACAN_2709	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
ACAN_2710	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
ACAN_2711	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
ACAN_2712	ENOG4105DFF	Rod shape-determining protein mreb
ACAN_2717	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
ACAN_2718	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
ACAN_2719	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_2720	ENOG4105C58	cytochrome c oxidase accessory protein ccog
ACAN_2721	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
ACAN_2722	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
ACAN_2726	ENOG4107QPK	)-transporter
ACAN_2729	ENOG4105C0B	DNA polymerase III (alpha subunit)
ACAN_2730	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
ACAN_2735	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ACAN_2737	ENOG4105C8P	)-transporter
ACAN_2738	ENOG4105F4G	Membrane
ACAN_2745	ENOG4105HFZ	Membrane
ACAN_2746	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
ACAN_2748	ENOG4105NU9	Preprotein translocase subunit SecG
ACAN_2749	ENOG4108ZJ4	polysaccharide deacetylase
ACAN_2750	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
ACAN_2751	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
ACAN_2753	ENOG4105D8G	Major Facilitator superfamily
ACAN_2754	ENOG410802Z	Protein of unknown function (DUF328)
ACAN_2755	ENOG4105K5B	UPF0225 protein
ACAN_2758	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
ACAN_2759	ENOG4108V0P	LemA family
ACAN_2762	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
ACAN_2764	ENOG4107QF7	multi-drug
ACAN_2768	ENOG4105CBX	hi0933 family
ACAN_2772	ENOG4105C6T	cysteine synthase
ACAN_2775	ENOG4105C11	sulfate adenylyltransferase), subunit 2
ACAN_2776	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
ACAN_2777	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
ACAN_2778	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACAN_2779	ENOG4105C8Q	Methyl-accepting chemotaxis
ACAN_2780	ENOG4107RN3	metallophosphoesterase
ACAN_2783	ENOG4105CI3	gtp-binding protein typa
ACAN_2784	ENOG41066VF	YeeE YedE family protein
ACAN_2785	ENOG4105KSU	Redox protein
ACAN_2786	ENOG4105CSV	Glutaminase
ACAN_2787	ENOG4105EN6	Membrane
ACAN_2788	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
ACAN_2789	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
ACAN_2790	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)