locus-tag	class	description
ACAN_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACAN_0002	COG0592	DNA-directed DNA polymerase activity
ACAN_0003	COG0187	DNA topoisomerase II activity
ACAN_0008	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACAN_0012	COG1238	metal cluster binding
ACAN_0013	COG4191	Histidine kinase
ACAN_0013	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAN_0014	COG0564	pseudouridine synthase activity
ACAN_0015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACAN_0016	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACAN_0017	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACAN_0019	COG0778	Nitroreductase
ACAN_0020	COG1151	hydroxylamine reductase activity
ACAN_0021	COG0493	'glutamate synthase
ACAN_0025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACAN_0028	COG1858	cytochrome C peroxidase
ACAN_0030	COG2207	Transcriptional regulator
ACAN_0030	COG4753	response regulator
ACAN_0031	COG3852	Histidine kinase
ACAN_0032	COG4771	TonB-dependent receptor
ACAN_0034	COG2205	protein histidine kinase activity
ACAN_0035	COG0745	RESPONSE REGULATOR receiver
ACAN_0037	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACAN_0038	COG0348	domain, Protein
ACAN_0039	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACAN_0040	COG3118	belongs to the thioredoxin family
ACAN_0041	COG1733	regulation of RNA biosynthetic process
ACAN_0042	COG0604	alcohol dehydrogenase
ACAN_0043	COG1733	regulation of RNA biosynthetic process
ACAN_0044	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACAN_0045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACAN_0048	COG0107	imidazoleglycerol-phosphate synthase activity
ACAN_0049	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACAN_0050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACAN_0051	COG0517	IMP dehydrogenase activity
ACAN_0051	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACAN_0052	COG1187	pseudouridine synthase activity
ACAN_0053	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ACAN_0053	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACAN_0055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACAN_0056	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACAN_0058	COG0840	transmembrane signaling receptor activity
ACAN_0059	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ACAN_0060	COG0778	Nitroreductase
ACAN_0062	COG0367	asparagine synthase
ACAN_0064	COG0306	phosphate transporter
ACAN_0066	COG0513	Belongs to the DEAD box helicase family
ACAN_0067	COG0439	Biotin carboxylase
ACAN_0068	COG0511	ligase activity, forming carbon-carbon bonds
ACAN_0072	COG1139	Iron-sulfur cluster binding protein
ACAN_0073	COG1556	Lactate utilization protein
ACAN_0074	COG3852	Histidine kinase
ACAN_0076	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ACAN_0081	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACAN_0082	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACAN_0084	COG0745	RESPONSE REGULATOR receiver
ACAN_0091	COG0390	transport system, permease component
ACAN_0092	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACAN_0093	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACAN_0096	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAN_0096	COG4191	Histidine kinase
ACAN_0097	COG0745	RESPONSE REGULATOR receiver
ACAN_0100	COG3220	belongs to the UPF0276 family
ACAN_0102	COG4191	Histidine kinase
ACAN_0107	COG0460	homoserine dehydrogenase
ACAN_0108	COG0436	Aminotransferase
ACAN_0111	COG0840	transmembrane signaling receptor activity
ACAN_0112	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACAN_0113	COG0254	rRNA binding
ACAN_0114	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACAN_0117	COG2199	diguanylate cyclase activity
ACAN_0134	COG2378	regulation of single-species biofilm formation
ACAN_0148	COG2239	Acts as a magnesium transporter
ACAN_0149	COG5001	Diguanylate cyclase
ACAN_0149	COG3706	GGDEF domain
ACAN_0149	COG2203	Gaf domain
ACAN_0149	COG4251	negative regulation of phosphorylation
ACAN_0150	COG4191	Histidine kinase
ACAN_0152	COG0492	ferredoxin-NADP+ reductase activity
ACAN_0153	COG0450	alkyl hydroperoxide reductase
ACAN_0154	COG4191	Histidine kinase
ACAN_0154	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAN_0156	COG3447	MASE1 domain protein
ACAN_0156	COG5002	protein histidine kinase activity
ACAN_0156	COG5001	Diguanylate cyclase
ACAN_0157	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACAN_0158	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACAN_0159	COG0237	dephospho-CoA kinase activity
ACAN_0160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACAN_0161	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACAN_0163	COG2353	YceI-like domain
ACAN_0164	COG1846	Transcriptional regulator
ACAN_0165	COG1280	lysine exporter protein (LysE YggA)
ACAN_0167	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACAN_0168	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACAN_0169	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACAN_0171	COG0505	Belongs to the CarA family
ACAN_0174	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACAN_0174	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACAN_0176	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACAN_0177	COG0489	protein tyrosine kinase activity
ACAN_0179	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACAN_0179	COG0140	phosphoribosyl-ATP diphosphatase activity
ACAN_0183	COG1410	methionine synthase
ACAN_0183	COG0646	methionine synthase
ACAN_0192	COG0277	FAD linked oxidase domain protein
ACAN_0194	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAN_0195	COG2226	methyltransferase
ACAN_0198	COG1739	Uncharacterized protein family UPF0029
ACAN_0199	COG1450	Type ii and iii secretion system protein
ACAN_0202	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACAN_0204	COG0069	glutamate synthase activity
ACAN_0207	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACAN_0208	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACAN_0209	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACAN_0210	COG0284	orotidine-5'-phosphate decarboxylase activity
ACAN_0228	COG1854	S-ribosylhomocysteine lyase activity
ACAN_0229	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACAN_0229	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACAN_0229	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACAN_0229	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACAN_0230	COG0546	phosphoglycolate phosphatase activity
ACAN_0231	COG0747	negative chemotaxis
ACAN_0232	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACAN_0233	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACAN_0234	COG3850	Histidine kinase
ACAN_0234	COG5002	protein histidine kinase activity
ACAN_0235	COG0745	RESPONSE REGULATOR receiver
ACAN_0238	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACAN_0240	COG0573	inorganic phosphate transmembrane transporter activity
ACAN_0241	COG2203	Gaf domain
ACAN_0241	COG2200	EAL domain
ACAN_0241	COG2199	diguanylate cyclase activity
ACAN_0243	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACAN_0244	COG0268	Binds directly to 16S ribosomal RNA
ACAN_0245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACAN_0246	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACAN_0247	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACAN_0248	COG0746	molybdenum cofactor guanylyltransferase activity
ACAN_0252	COG0243	molybdopterin cofactor binding
ACAN_0253	COG0437	4 iron, 4 sulfur cluster binding
ACAN_0257	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACAN_0258	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACAN_0259	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACAN_0266	COG0575	Belongs to the CDS family
ACAN_0267	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACAN_0271	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACAN_0272	COG0023	Translation Initiation Factor
ACAN_0273	COG1115	amino acid carrier protein
ACAN_0274	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACAN_0274	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACAN_0276	COG2022	thiamine diphosphate biosynthetic process
ACAN_0287	COG4974	Belongs to the 'phage' integrase family
ACAN_0294	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ACAN_0295	COG3421	Type III restriction
ACAN_0296	COG3586	endonuclease activity
ACAN_0316	COG0745	RESPONSE REGULATOR receiver
ACAN_0317	COG2203	Gaf domain
ACAN_0317	COG3706	GGDEF domain
ACAN_0317	COG4251	negative regulation of phosphorylation
ACAN_0317	COG5001	Diguanylate cyclase
ACAN_0318	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACAN_0319	COG0585	pseudouridine synthase activity
ACAN_0321	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACAN_0322	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAN_0323	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACAN_0326	COG0793	Belongs to the peptidase S41A family
ACAN_0327	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACAN_0328	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACAN_0329	COG0047	phosphoribosylformylglycinamidine synthase activity
ACAN_0331	COG0204	Acyl-transferase
ACAN_0332	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACAN_0334	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACAN_0335	COG0018	arginyl-trna synthetase
ACAN_0337	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACAN_0339	COG0126	phosphoglycerate kinase activity
ACAN_0340	COG0149	triose-phosphate isomerase activity
ACAN_0341	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACAN_0342	COG0019	diaminopimelate decarboxylase activity
ACAN_0343	COG0647	UMP catabolic process
ACAN_0344	COG0077	Prephenate dehydratase
ACAN_0344	COG1605	Chorismate mutase
ACAN_0345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACAN_0346	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACAN_0347	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAN_0349	COG0424	maF-like protein
ACAN_0354	COG0791	NLP P60 protein
ACAN_0356	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACAN_0357	COG3118	belongs to the thioredoxin family
ACAN_0358	COG5002	protein histidine kinase activity
ACAN_0359	COG0745	RESPONSE REGULATOR receiver
ACAN_0360	COG1115	amino acid carrier protein
ACAN_0361	COG0492	ferredoxin-NADP+ reductase activity
ACAN_0362	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACAN_0363	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACAN_0364	COG1242	4 iron, 4 sulfur cluster binding
ACAN_0366	COG0210	DNA helicase
ACAN_0367	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACAN_0368	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACAN_0369	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACAN_0370	COG3278	Belongs to the heme-copper respiratory oxidase family
ACAN_0378	COG0814	amino acid
ACAN_0379	COG4773	Receptor
ACAN_0380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACAN_0382	COG4773	Receptor
ACAN_0384	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACAN_0386	COG0157	Belongs to the NadC ModD family
ACAN_0389	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACAN_0391	COG0083	homoserine kinase activity
ACAN_0393	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACAN_0394	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACAN_0395	COG0779	Required for maturation of 30S ribosomal subunits
ACAN_0396	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACAN_0396	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACAN_0397	COG3501	Rhs element vgr protein
ACAN_0400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACAN_0401	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACAN_0402	COG1185	polyribonucleotide nucleotidyltransferase activity
ACAN_0402	COG0539	negative regulation of cytoplasmic translation
ACAN_0403	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACAN_0404	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACAN_0405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAN_0405	COG0072	phenylalanine-tRNA ligase activity
ACAN_0406	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACAN_0407	COG0537	adenosine 5'-monophosphoramidase activity
ACAN_0408	COG0825	malonyl-CoA metabolic process
ACAN_0409	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACAN_0410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACAN_0414	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACAN_0415	COG0303	'Molybdopterin
ACAN_0417	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACAN_0420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACAN_0422	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACAN_0423	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACAN_0424	COG3706	GGDEF domain
ACAN_0425	COG1074	ATP-dependent DNA helicase activity
ACAN_0426	COG0840	transmembrane signaling receptor activity
ACAN_0427	COG0352	thiamine-phosphate diphosphorylase activity
ACAN_0428	COG0840	transmembrane signaling receptor activity
ACAN_0429	COG0356	it plays a direct role in the translocation of protons across the membrane
ACAN_0430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACAN_0431	COG0336	Belongs to the RNA methyltransferase TrmD family
ACAN_0432	COG0335	large ribosomal subunit rRNA binding
ACAN_0436	COG1028	Short-chain dehydrogenase reductase Sdr
ACAN_0438	COG2966	Psort location CytoplasmicMembrane, score
ACAN_0441	COG2199	diguanylate cyclase activity
ACAN_0441	COG2200	EAL domain
ACAN_0441	COG3287	FIST C domain
ACAN_0443	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACAN_0444	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACAN_0447	COG0180	Tryptophanyl-tRNA synthetase
ACAN_0452	COG1971	Probably functions as a manganese efflux pump
ACAN_0454	COG2814	Major facilitator Superfamily
ACAN_0455	COG1132	(ABC) transporter
ACAN_0456	COG1132	(ABC) transporter
ACAN_0457	COG4771	TonB-dependent receptor
ACAN_0459	COG4771	TonB-dependent receptor
ACAN_0461	COG1629	transport
ACAN_0462	COG0784	Response regulator, receiver
ACAN_0466	COG0848	biopolymer transport protein
ACAN_0467	COG0811	peptide transport
ACAN_0468	COG0811	peptide transport
ACAN_0475	COG4774	siderophore transport
ACAN_0476	COG2169	Transcriptional regulator
ACAN_0476	COG1917	Cupin 2, conserved barrel domain protein
ACAN_0478	COG4773	Receptor
ACAN_0479	COG4753	response regulator
ACAN_0479	COG2207	Transcriptional regulator
ACAN_0480	COG3852	Histidine kinase
ACAN_0484	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACAN_0485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACAN_0485	COG1333	cytochrome c biogenesis protein
ACAN_0486	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ACAN_0487	COG3005	denitrification pathway
ACAN_0489	COG0840	transmembrane signaling receptor activity
ACAN_0493	COG3043	anaerobic respiration
ACAN_0494	COG0348	domain, Protein
ACAN_0495	COG0437	4 iron, 4 sulfur cluster binding
ACAN_0496	COG0243	molybdopterin cofactor binding
ACAN_0497	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACAN_0497	COG1648	precorrin-2 dehydrogenase activity
ACAN_0500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACAN_0502	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACAN_0504	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACAN_0506	COG2404	hydrolase activity, acting on ester bonds
ACAN_0508	COG0579	oxidoreductase
ACAN_0511	COG0745	RESPONSE REGULATOR receiver
ACAN_0519	COG0642	Histidine kinase
ACAN_0520	COG0745	RESPONSE REGULATOR receiver
ACAN_0521	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAN_0522	COG0191	fructose-bisphosphate aldolase activity
ACAN_0524	COG2205	protein histidine kinase activity
ACAN_0526	COG0848	biopolymer transport protein
ACAN_0527	COG0811	peptide transport
ACAN_0530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACAN_0531	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACAN_0533	COG0142	geranyltranstransferase activity
ACAN_0534	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACAN_0535	COG0442	prolyl-tRNA aminoacylation
ACAN_0536	COG0668	transmembrane transport
ACAN_0537	COG0617	tRNA 3'-terminal CCA addition
ACAN_0540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACAN_0541	COG1862	Preprotein translocase
ACAN_0542	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACAN_0543	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACAN_0547	COG0495	leucyl-tRNA aminoacylation
ACAN_0549	COG0285	dihydrofolate synthase activity
ACAN_0550	COG0739	heme binding
ACAN_0556	COG0577	efflux transmembrane transporter activity
ACAN_0556	COG1136	(ABC) transporter
ACAN_0557	COG0577	efflux transmembrane transporter activity
ACAN_0557	COG1136	(ABC) transporter
ACAN_0558	COG4771	TonB-dependent receptor
ACAN_0562	COG0784	Response regulator, receiver
ACAN_0567	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACAN_0571	COG1053	succinate dehydrogenase
ACAN_0571	COG3976	FMN-binding domain protein
ACAN_0572	COG3852	Histidine kinase
ACAN_0573	COG0745	RESPONSE REGULATOR receiver
ACAN_0575	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACAN_0577	COG0745	RESPONSE REGULATOR receiver
ACAN_0578	COG0642	Histidine kinase
ACAN_0579	COG2081	HI0933 family
ACAN_0580	COG1692	metallophosphoesterase
ACAN_0584	COG2226	methyltransferase
ACAN_0585	COG1570	exodeoxyribonuclease VII activity
ACAN_0586	COG0840	transmembrane signaling receptor activity
ACAN_0587	COG0840	transmembrane signaling receptor activity
ACAN_0588	COG0835	chemotaxis
ACAN_0590	COG2204	response regulator
ACAN_0591	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACAN_0593	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACAN_0594	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACAN_0597	COG0459	protein refolding
ACAN_0600	COG2076	Multidrug Resistance protein
ACAN_0603	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACAN_0604	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACAN_0605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACAN_0606	COG0352	thiamine-phosphate diphosphorylase activity
ACAN_0607	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACAN_0610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACAN_0611	COG2264	protein methyltransferase activity
ACAN_0612	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAN_0614	COG0784	Response regulator, receiver
ACAN_0614	COG3437	response regulator, receiver
ACAN_0616	COG4191	Histidine kinase
ACAN_0617	COG4251	negative regulation of phosphorylation
ACAN_0617	COG5001	Diguanylate cyclase
ACAN_0617	COG3706	GGDEF domain
ACAN_0617	COG2203	Gaf domain
ACAN_0618	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACAN_0619	COG0475	glutathione-regulated potassium exporter activity
ACAN_0619	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACAN_0624	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACAN_0626	COG1309	transcriptional regulator
ACAN_0627	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACAN_0629	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACAN_0630	COG1090	epimerase
ACAN_0631	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACAN_0634	COG0481	GTPase activity
ACAN_0636	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACAN_0637	COG0482	sulfurtransferase activity
ACAN_0638	COG0482	sulfurtransferase activity
ACAN_0639	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACAN_0640	COG0006	proline dipeptidase activity
ACAN_0641	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACAN_0642	COG0402	S-adenosylhomocysteine deaminase activity
ACAN_0643	COG0616	signal peptide processing
ACAN_0644	COG0513	Belongs to the DEAD box helicase family
ACAN_0645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACAN_0646	COG0280	phosphate acetyltransferase
ACAN_0647	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACAN_0648	COG2176	DNA-directed DNA polymerase activity
ACAN_0652	COG2176	DNA-directed DNA polymerase activity
ACAN_0654	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACAN_0656	COG0745	RESPONSE REGULATOR receiver
ACAN_0671	COG0579	oxidoreductase
ACAN_0672	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACAN_0675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACAN_0680	COG0714	Associated with various cellular activities
ACAN_0681	COG0741	lytic transglycosylase activity
ACAN_0682	COG0052	Belongs to the universal ribosomal protein uS2 family
ACAN_0683	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACAN_0684	COG1136	(ABC) transporter
ACAN_0686	COG0194	GDP metabolic process
ACAN_0687	COG5002	protein histidine kinase activity
ACAN_0687	COG5001	Diguanylate cyclase
ACAN_0688	COG0252	asparaginase activity
ACAN_0689	COG2217	Heavy metal translocating P-type atpase
ACAN_0692	COG1132	(ABC) transporter
ACAN_0693	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACAN_0695	COG3437	response regulator, receiver
ACAN_0695	COG0784	Response regulator, receiver
ACAN_0696	COG1355	regulation of microtubule-based process
ACAN_0697	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACAN_0698	COG1121	(ABC) transporter
ACAN_0699	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACAN_0700	COG2996	Protein conserved in bacteria
ACAN_0701	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACAN_0703	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACAN_0704	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACAN_0705	COG0300	oxidoreductase activity
ACAN_0711	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACAN_0713	COG0210	DNA helicase
ACAN_0714	COG3706	GGDEF domain
ACAN_0715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACAN_0729	COG0525	valine-tRNA ligase activity
ACAN_0730	COG1733	regulation of RNA biosynthetic process
ACAN_0734	COG0745	RESPONSE REGULATOR receiver
ACAN_0735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACAN_0739	COG2814	Major facilitator Superfamily
ACAN_0740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACAN_0744	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACAN_0745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACAN_0746	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACAN_0749	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACAN_0752	COG0840	transmembrane signaling receptor activity
ACAN_0754	COG2217	Heavy metal translocating P-type atpase
ACAN_0758	COG0450	alkyl hydroperoxide reductase
ACAN_0759	COG2354	Protein conserved in bacteria
ACAN_0762	COG0444	Belongs to the ABC transporter superfamily
ACAN_0763	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAN_0764	COG0601	transmembrane transport
ACAN_0765	COG0747	negative chemotaxis
ACAN_0768	COG0840	transmembrane signaling receptor activity
ACAN_0769	COG0840	transmembrane signaling receptor activity
ACAN_0770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACAN_0776	COG1858	cytochrome C peroxidase
ACAN_0777	COG1028	Short-chain dehydrogenase reductase Sdr
ACAN_0781	COG1917	Cupin 2, conserved barrel domain protein
ACAN_0781	COG2207	Transcriptional regulator
ACAN_0783	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACAN_0784	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ACAN_0789	COG0626	cystathionine gamma-synthase activity
ACAN_0790	COG1242	4 iron, 4 sulfur cluster binding
ACAN_0791	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACAN_0801	COG2151	metal-sulfur cluster biosynthetic enzyme
ACAN_0802	COG2166	iron-sulfur cluster assembly
ACAN_0803	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACAN_0804	COG0719	Fe-S assembly protein
ACAN_0805	COG0396	ATPase activity
ACAN_0806	COG0719	Fe-S assembly protein
ACAN_0807	COG0765	amino acid transport
ACAN_0809	COG1104	cysteine desulfurase activity
ACAN_0810	COG2906	2 iron, 2 sulfur cluster binding
ACAN_0810	COG0822	iron-sulfur transferase activity
ACAN_0810	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACAN_0814	COG0165	Argininosuccinate lyase
ACAN_0815	COG0745	RESPONSE REGULATOR receiver
ACAN_0816	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACAN_0817	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACAN_0818	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACAN_0821	COG0556	nucleotide-excision repair
ACAN_0824	COG0779	Required for maturation of 30S ribosomal subunits
ACAN_0825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACAN_0832	COG0698	ribose 5-phosphate isomerase
ACAN_0833	COG0681	Belongs to the peptidase S26 family
ACAN_0834	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACAN_0836	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACAN_0837	COG0193	aminoacyl-tRNA hydrolase activity
ACAN_0840	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACAN_0842	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACAN_0843	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACAN_0844	COG1758	RNA polymerase activity
ACAN_0845	COG0528	UMP kinase activity
ACAN_0847	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACAN_0848	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACAN_0849	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACAN_0851	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACAN_0852	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACAN_0855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACAN_0856	COG0305	Participates in initiation and elongation during chromosome replication
ACAN_0858	COG0166	Belongs to the GPI family
ACAN_0863	COG1943	Transposase
ACAN_0864	COG1793	dna ligase
ACAN_0866	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACAN_0866	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACAN_0867	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACAN_0869	COG0133	tryptophan synthase activity
ACAN_0871	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACAN_0874	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACAN_0875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACAN_0877	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACAN_0879	COG2030	dehydratase
ACAN_0880	COG0463	Glycosyl transferase, family 2
ACAN_0880	COG1216	Glycosyl transferase, family 2
ACAN_0881	COG2089	acid synthase
ACAN_0885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACAN_0889	COG0673	inositol 2-dehydrogenase activity
ACAN_0890	COG1063	alcohol dehydrogenase
ACAN_0897	COG2026	Addiction module toxin, RelE StbE family
ACAN_0898	COG2161	toxin-antitoxin pair type II binding
ACAN_0899	COG4115	mRNA cleavage
ACAN_0900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACAN_0901	COG1086	Polysaccharide biosynthesis protein
ACAN_0906	COG3123	guanosine phosphorylase activity
ACAN_0910	COG4139	cobalamin transport
ACAN_0912	COG4974	Belongs to the 'phage' integrase family
ACAN_0914	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACAN_0918	COG1475	DNA binding
ACAN_0923	COG3620	sequence-specific DNA binding
ACAN_0961	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACAN_0962	COG0585	pseudouridine synthase activity
ACAN_0964	COG0840	transmembrane signaling receptor activity
ACAN_0965	COG0632	four-way junction helicase activity
ACAN_0966	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACAN_0968	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACAN_0972	COG0581	inorganic phosphate transmembrane transporter activity
ACAN_0973	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACAN_0975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAN_0978	COG0051	transcription antitermination factor activity, RNA binding
ACAN_0979	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACAN_0980	COG0088	Forms part of the polypeptide exit tunnel
ACAN_0981	COG0089	rRNA binding
ACAN_0982	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACAN_0983	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACAN_0984	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACAN_0985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACAN_0986	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACAN_0987	COG0255	Belongs to the universal ribosomal protein uL29 family
ACAN_0988	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACAN_0989	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACAN_0990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACAN_0991	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACAN_0992	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACAN_0993	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACAN_0994	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACAN_0996	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACAN_0997	COG0200	Binds to the 23S rRNA
ACAN_0998	COG0201	protein transport
ACAN_0999	COG0024	Methionine aminopeptidase
ACAN_1000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACAN_1001	COG3706	GGDEF domain
ACAN_1003	COG1573	uracil-dna glycosylase
ACAN_1005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACAN_1008	COG1032	radical SAM domain protein
ACAN_1010	COG0563	adenylate kinase activity
ACAN_1013	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACAN_1014	COG0322	excinuclease ABC activity
ACAN_1017	COG3201	nicotinamide mononucleotide transporter
ACAN_1021	COG0484	heat shock protein binding
ACAN_1022	COG1620	l-lactate permease
ACAN_1023	COG0840	transmembrane signaling receptor activity
ACAN_1024	COG0484	heat shock protein binding
ACAN_1027	COG0724	RNA recognition motif
ACAN_1028	COG0708	Exodeoxyribonuclease III
ACAN_1033	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAN_1034	COG0765	amino acid transport
ACAN_1037	COG1528	Iron-storage protein
ACAN_1038	COG1227	inorganic diphosphatase activity
ACAN_1041	COG0010	Belongs to the arginase family
ACAN_1050	COG0702	epimerase
ACAN_1055	COG0326	Molecular chaperone. Has ATPase activity
ACAN_1060	COG0583	DNA-binding transcription factor activity
ACAN_1062	COG1566	PFAM secretion protein HlyD family protein
ACAN_1066	COG1846	Transcriptional regulator
ACAN_1071	COG0840	transmembrane signaling receptor activity
ACAN_1072	COG0840	transmembrane signaling receptor activity
ACAN_1073	COG4753	response regulator
ACAN_1073	COG2207	Transcriptional regulator
ACAN_1074	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAN_1077	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACAN_1079	COG1984	allophanate hydrolase subunit 2
ACAN_1084	COG2183	response to ionizing radiation
ACAN_1086	COG2890	protein-(glutamine-N5) methyltransferase activity
ACAN_1088	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ACAN_1091	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACAN_1094	COG0492	ferredoxin-NADP+ reductase activity
ACAN_1095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACAN_1095	COG0475	glutathione-regulated potassium exporter activity
ACAN_1096	COG0745	RESPONSE REGULATOR receiver
ACAN_1096	COG3706	GGDEF domain
ACAN_1097	COG0693	protein deglycase activity
ACAN_1099	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACAN_1102	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ACAN_1103	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACAN_1105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACAN_1107	COG0439	Biotin carboxylase
ACAN_1108	COG0288	reversible hydration of carbon dioxide
ACAN_1124	COG0784	Response regulator, receiver
ACAN_1124	COG5002	protein histidine kinase activity
ACAN_1125	COG4999	Histidine kinase
ACAN_1125	COG3850	Histidine kinase
ACAN_1125	COG2205	protein histidine kinase activity
ACAN_1125	COG3437	response regulator, receiver
ACAN_1127	COG0745	RESPONSE REGULATOR receiver
ACAN_1130	COG2199	diguanylate cyclase activity
ACAN_1130	COG3287	FIST C domain
ACAN_1130	COG2200	EAL domain
ACAN_1135	COG0739	heme binding
ACAN_1136	COG0217	transcriptional regulatory protein
ACAN_1138	COG4783	chaperone-mediated protein folding
ACAN_1141	COG1960	acyl-CoA dehydrogenase activity
ACAN_1142	COG1049	propionate catabolic process, 2-methylcitrate cycle
ACAN_1144	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ACAN_1146	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ACAN_1147	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ACAN_1148	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ACAN_1149	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACAN_1151	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACAN_1152	COG0733	neurotransmitter:sodium symporter activity
ACAN_1153	COG2814	Major facilitator Superfamily
ACAN_1154	COG0840	transmembrane signaling receptor activity
ACAN_1156	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACAN_1157	COG0298	carbon dioxide binding
ACAN_1158	COG0409	Hydrogenase expression formation protein
ACAN_1159	COG0309	Hydrogenase expression formation protein (HypE)
ACAN_1160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACAN_1160	COG1024	Enoyl-CoA hydratase
ACAN_1161	COG0375	protein maturation
ACAN_1162	COG3706	GGDEF domain
ACAN_1164	COG1648	precorrin-2 dehydrogenase activity
ACAN_1164	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACAN_1168	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACAN_1169	COG2171	N-acyltransferase activity
ACAN_1170	COG1047	Peptidyl-prolyl cis-trans
ACAN_1174	COG2884	Cell division ATP-binding protein ftsE
ACAN_1175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACAN_1177	COG0564	pseudouridine synthase activity
ACAN_1178	COG0772	Belongs to the SEDS family
ACAN_1180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACAN_1184	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACAN_1185	COG0066	3-isopropylmalate dehydratase activity
ACAN_1186	COG0473	3-isopropylmalate dehydrogenase activity
ACAN_1189	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAN_1191	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACAN_1192	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACAN_1193	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACAN_1194	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACAN_1195	COG0202	RNA polymerase activity
ACAN_1196	COG0203	ribosomal protein L17
ACAN_1197	COG0154	amidase activity
ACAN_1198	COG0517	IMP dehydrogenase activity
ACAN_1198	COG0516	GMP reductase activity
ACAN_1201	COG0456	acetyltransferase
ACAN_1214	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACAN_1216	COG2003	Belongs to the UPF0758 family
ACAN_1221	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACAN_1222	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACAN_1223	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACAN_1228	COG0420	3'-5' exonuclease activity
ACAN_1229	COG0419	ATPase involved in DNA repair
ACAN_1237	COG2084	Dehydrogenase
ACAN_1239	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACAN_1240	COG0251	oxidation-reduction process
ACAN_1241	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACAN_1242	COG1879	ABC-type sugar transport system periplasmic component
ACAN_1243	COG3852	Histidine kinase
ACAN_1244	COG1846	Transcriptional regulator
ACAN_1249	COG0745	RESPONSE REGULATOR receiver
ACAN_1250	COG0745	RESPONSE REGULATOR receiver
ACAN_1251	COG0745	RESPONSE REGULATOR receiver
ACAN_1252	COG2198	Histidine kinase
ACAN_1252	COG0643	Histidine kinase
ACAN_1254	COG0835	chemotaxis
ACAN_1255	COG2201	protein-glutamate methylesterase activity
ACAN_1257	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAN_1260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACAN_1262	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAN_1265	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACAN_1266	COG0471	metal ion transport
ACAN_1267	COG1193	negative regulation of DNA recombination
ACAN_1270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACAN_1274	COG0454	-acetyltransferase
ACAN_1277	COG1742	UPF0060 membrane protein
ACAN_1280	COG2258	MOSC domain
ACAN_1281	COG2824	Alkylphosphonate utilization operon protein PhnA
ACAN_1282	COG2207	Transcriptional regulator
ACAN_1289	COG1733	regulation of RNA biosynthetic process
ACAN_1290	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACAN_1292	COG0778	Nitroreductase
ACAN_1294	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
ACAN_1295	COG0840	transmembrane signaling receptor activity
ACAN_1296	COG0840	transmembrane signaling receptor activity
ACAN_1297	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACAN_1303	COG3046	protein related to deoxyribodipyrimidine photolyase
ACAN_1304	COG2200	EAL domain
ACAN_1305	COG0352	thiamine-phosphate diphosphorylase activity
ACAN_1306	COG0157	Belongs to the NadC ModD family
ACAN_1307	COG4149	molybdate abc transporter
ACAN_1309	COG3842	ATPase activity
ACAN_1315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAN_1317	COG0488	(ABC) transporter
ACAN_1318	COG1607	acyl-coa hydrolase
ACAN_1319	COG1607	acyl-coa hydrolase
ACAN_1320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACAN_1321	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACAN_1322	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACAN_1323	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAN_1325	COG0114	fumarate hydratase activity
ACAN_1329	COG2030	dehydratase
ACAN_1330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACAN_1333	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACAN_1334	COG2199	diguanylate cyclase activity
ACAN_1334	COG2200	EAL domain
ACAN_1334	COG3287	FIST C domain
ACAN_1335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACAN_1335	COG1333	cytochrome c biogenesis protein
ACAN_1336	COG0500	methyltransferase
ACAN_1337	COG2203	Gaf domain
ACAN_1337	COG3706	GGDEF domain
ACAN_1337	COG4251	negative regulation of phosphorylation
ACAN_1337	COG5001	Diguanylate cyclase
ACAN_1340	COG2833	Protein of unknown function (DUF455)
ACAN_1341	COG0133	tryptophan synthase activity
ACAN_1342	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ACAN_1343	COG0484	heat shock protein binding
ACAN_1345	COG0840	transmembrane signaling receptor activity
ACAN_1346	COG0840	transmembrane signaling receptor activity
ACAN_1349	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACAN_1349	COG3153	acetyltransferase
ACAN_1350	COG3706	GGDEF domain
ACAN_1350	COG0745	RESPONSE REGULATOR receiver
ACAN_1351	COG4191	Histidine kinase
ACAN_1352	COG0745	RESPONSE REGULATOR receiver
ACAN_1354	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACAN_1354	COG2207	Transcriptional regulator
ACAN_1361	COG0840	transmembrane signaling receptor activity
ACAN_1363	COG0840	transmembrane signaling receptor activity
ACAN_1365	COG0745	RESPONSE REGULATOR receiver
ACAN_1367	COG1794	racemase activity, acting on amino acids and derivatives
ACAN_1376	COG0137	argininosuccinate synthase activity
ACAN_1378	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACAN_1379	COG0802	atpase or kinase
ACAN_1380	COG1137	ATPase activity
ACAN_1381	COG3706	GGDEF domain
ACAN_1382	COG5001	Diguanylate cyclase
ACAN_1382	COG5002	protein histidine kinase activity
ACAN_1383	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACAN_1385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACAN_1385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACAN_1386	COG0745	RESPONSE REGULATOR receiver
ACAN_1389	COG0840	transmembrane signaling receptor activity
ACAN_1390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACAN_1392	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACAN_1393	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACAN_1398	COG0189	ligase activity
ACAN_1401	COG3852	Histidine kinase
ACAN_1402	COG0113	porphobilinogen synthase activity
ACAN_1403	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACAN_1404	COG0357	Ribosomal RNA small subunit methyltransferase G
ACAN_1415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACAN_1416	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ACAN_1421	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAN_1421	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAN_1423	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACAN_1428	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACAN_1429	COG0612	Peptidase, M16
ACAN_1430	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACAN_1431	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACAN_1432	COG0287	Prephenate dehydrogenase
ACAN_1433	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACAN_1436	COG0527	aspartate kinase activity
ACAN_1438	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACAN_1439	COG2890	protein-(glutamine-N5) methyltransferase activity
ACAN_1440	COG0339	signal peptide processing
ACAN_1457	COG0515	serine threonine protein kinase
ACAN_1457	COG2815	serine threonine protein kinase
ACAN_1459	COG3501	Rhs element vgr protein
ACAN_1464	COG0582	viral genome integration into host DNA
ACAN_1465	COG2201	protein-glutamate methylesterase activity
ACAN_1466	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACAN_1467	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAN_1469	COG0745	RESPONSE REGULATOR receiver
ACAN_1470	COG1185	polyribonucleotide nucleotidyltransferase activity
ACAN_1472	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACAN_1474	COG0151	Belongs to the GarS family
ACAN_1476	COG1160	GTP binding
ACAN_1478	COG1196	nuclear chromosome segregation
ACAN_1478	COG1674	ftsk spoiiie
ACAN_1479	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACAN_1480	COG0440	acetolactate synthase activity
ACAN_1481	COG0028	Belongs to the TPP enzyme family
ACAN_1482	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACAN_1483	COG0248	Ppx GppA phosphatase
ACAN_1485	COG2203	Gaf domain
ACAN_1485	COG5001	Diguanylate cyclase
ACAN_1485	COG3706	GGDEF domain
ACAN_1485	COG4251	negative regulation of phosphorylation
ACAN_1488	COG3118	belongs to the thioredoxin family
ACAN_1490	COG1683	Conserved Protein
ACAN_1491	COG0037	tRNA processing
ACAN_1492	COG2056	Na+-H+ antiporter family
ACAN_1494	COG0189	ligase activity
ACAN_1494	COG4067	protein conserved in archaea
ACAN_1497	COG1012	belongs to the aldehyde dehydrogenase family
ACAN_1498	COG0410	ABC transporter
ACAN_1501	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACAN_1506	COG0745	RESPONSE REGULATOR receiver
ACAN_1508	COG0303	'Molybdopterin
ACAN_1511	COG1322	Protein conserved in bacteria
ACAN_1512	COG0501	Belongs to the peptidase M48B family
ACAN_1514	COG5002	protein histidine kinase activity
ACAN_1515	COG0824	Thioesterase
ACAN_1518	COG0667	Aldo Keto reductase
ACAN_1521	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ACAN_1522	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACAN_1524	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACAN_1525	COG4206	TonB-dependent receptor
ACAN_1527	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACAN_1531	COG1797	cobyrinic acid a,c-diamide synthase activity
ACAN_1534	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ACAN_1542	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAN_1545	COG0546	phosphoglycolate phosphatase activity
ACAN_1549	COG0848	biopolymer transport protein
ACAN_1550	COG0811	peptide transport
ACAN_1551	COG5002	protein histidine kinase activity
ACAN_1552	COG0745	RESPONSE REGULATOR receiver
ACAN_1556	COG0788	formyltetrahydrofolate deformylase activity
ACAN_1557	COG0281	malic enzyme
ACAN_1557	COG0280	phosphate acetyltransferase
ACAN_1559	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACAN_1563	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACAN_1563	COG0301	tRNA thio-modification
ACAN_1565	COG0754	glutathionylspermidine amidase activity
ACAN_1567	COG1663	tetraacyldisaccharide 4'-kinase activity
ACAN_1568	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACAN_1569	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACAN_1573	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACAN_1574	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACAN_1575	COG0805	protein transport
ACAN_1576	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACAN_1577	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACAN_1578	COG0733	neurotransmitter:sodium symporter activity
ACAN_1585	COG4865	methylaspartate mutase activity
ACAN_1588	COG2863	cytochrome
ACAN_1589	COG2199	diguanylate cyclase activity
ACAN_1594	COG0275	rRNA processing
ACAN_1596	COG0776	regulation of translation
ACAN_1602	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACAN_1604	COG0456	acetyltransferase
ACAN_1605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACAN_1606	COG1917	Cupin 2, conserved barrel domain protein
ACAN_1609	COG0527	aspartate kinase activity
ACAN_1613	COG2863	cytochrome
ACAN_1615	COG5002	protein histidine kinase activity
ACAN_1616	COG0745	RESPONSE REGULATOR receiver
ACAN_1633	COG2200	EAL domain
ACAN_1633	COG3287	FIST C domain
ACAN_1633	COG2199	diguanylate cyclase activity
ACAN_1634	COG0840	transmembrane signaling receptor activity
ACAN_1634	COG0840	transmembrane signaling receptor activity
ACAN_1635	COG1132	(ABC) transporter
ACAN_1640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACAN_1641	COG0653	protein targeting
ACAN_1644	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACAN_1647	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACAN_1647	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAN_1649	COG2201	protein-glutamate methylesterase activity
ACAN_1652	COG0484	heat shock protein binding
ACAN_1653	COG0789	Transcriptional regulator
ACAN_1654	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACAN_1655	COG0849	cell division
ACAN_1657	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACAN_1662	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACAN_1664	COG0768	penicillin binding
ACAN_1665	COG1338	Plays a role in the flagellum-specific transport system
ACAN_1670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACAN_1672	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACAN_1675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACAN_1676	COG0131	Imidazoleglycerol-phosphate dehydratase
ACAN_1677	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACAN_1679	COG0084	hydrolase, TatD family'
ACAN_1682	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACAN_1683	COG0359	binds to the 23S rRNA
ACAN_1685	COG0163	prenyltransferase activity
ACAN_1686	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACAN_1687	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACAN_1688	COG0124	histidyl-tRNA synthetase
ACAN_1689	COG1166	arginine decarboxylase activity
ACAN_1690	COG1045	serine acetyltransferase
ACAN_1692	COG1473	amidohydrolase
ACAN_1693	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACAN_1694	COG1012	belongs to the aldehyde dehydrogenase family
ACAN_1695	COG0006	proline dipeptidase activity
ACAN_1697	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACAN_1699	COG1301	dicarboxylic acid transport
ACAN_1701	COG4536	flavin adenine dinucleotide binding
ACAN_1702	COG0748	coenzyme F420 binding
ACAN_1704	COG0259	pyridoxamine-phosphate oxidase activity
ACAN_1705	COG0386	Belongs to the glutathione peroxidase family
ACAN_1712	COG2011	ABC-type metal ion transport system permease component
ACAN_1713	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAN_1715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ACAN_1716	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACAN_1717	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACAN_1720	COG0659	secondary active sulfate transmembrane transporter activity
ACAN_1722	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACAN_1723	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACAN_1726	COG1489	DNA binding
ACAN_1729	COG2133	pyrroloquinoline quinone binding
ACAN_1730	COG1643	Atp-dependent helicase
ACAN_1731	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAN_1737	COG0596	Alpha beta hydrolase
ACAN_1737	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACAN_1737	COG2226	methyltransferase
ACAN_1742	COG1278	Cold shock
ACAN_1745	COG0513	Belongs to the DEAD box helicase family
ACAN_1762	COG0519	Catalyzes the synthesis of GMP from XMP
ACAN_1762	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACAN_1765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACAN_1768	COG0436	Aminotransferase
ACAN_1769	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACAN_1771	COG0840	transmembrane signaling receptor activity
ACAN_1772	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACAN_1774	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACAN_1775	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACAN_1776	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACAN_1777	COG0095	Lipoate-protein ligase
ACAN_1778	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACAN_1779	COG0039	L-malate dehydrogenase activity
ACAN_1780	COG0488	(ABC) transporter
ACAN_1781	COG1610	YqeY-like protein
ACAN_1782	COG3706	GGDEF domain
ACAN_1785	COG1136	(ABC) transporter
ACAN_1788	COG1320	monovalent cation:proton antiporter activity
ACAN_1789	COG2212	antiporter activity
ACAN_1790	COG1863	multisubunit Na H antiporter MnhE subunit
ACAN_1791	COG0651	ATP synthesis coupled electron transport
ACAN_1792	COG1006	Multisubunit Na H antiporter MnhC subunit
ACAN_1793	COG2111	Na H antiporter
ACAN_1793	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAN_1794	COG0300	oxidoreductase activity
ACAN_1795	COG1757	Na H antiporter
ACAN_1796	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAN_1797	COG0742	ribosomal rna small subunit methyltransferase
ACAN_1798	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACAN_1799	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACAN_1801	COG1418	mRNA catabolic process
ACAN_1803	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACAN_1804	COG0552	protein localization to endoplasmic reticulum
ACAN_1807	COG5002	protein histidine kinase activity
ACAN_1808	COG3258	Cytochrome c
ACAN_1809	COG3150	esterase
ACAN_1813	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACAN_1816	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACAN_1819	COG0783	Belongs to the Dps family
ACAN_1820	COG1592	Rubrerythrin
ACAN_1823	COG0728	peptidoglycan biosynthetic process
ACAN_1824	COG1132	(ABC) transporter
ACAN_1825	COG0167	dihydroorotate dehydrogenase activity
ACAN_1827	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACAN_1828	COG1028	Short-chain dehydrogenase reductase Sdr
ACAN_1829	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACAN_1830	COG0750	zinc metalloprotease
ACAN_1831	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACAN_1836	COG0134	indole-3-glycerol-phosphate synthase activity
ACAN_1838	COG0727	PFAM Uncharacterised protein family (UPF0153)
ACAN_1839	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACAN_1841	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACAN_1841	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACAN_1842	COG0028	Belongs to the TPP enzyme family
ACAN_1844	COG2076	Multidrug Resistance protein
ACAN_1846	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACAN_1847	COG2176	DNA-directed DNA polymerase activity
ACAN_1848	COG0135	phosphoribosylanthranilate isomerase activity
ACAN_1849	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACAN_1850	COG3008	intermembrane lipid transfer
ACAN_1851	COG2995	paraquat-inducible protein a
ACAN_1852	COG2995	paraquat-inducible protein a
ACAN_1853	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACAN_1856	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ACAN_1865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACAN_1867	COG3706	GGDEF domain
ACAN_1868	COG0666	response to abiotic stimulus
ACAN_1873	COG0745	RESPONSE REGULATOR receiver
ACAN_1874	COG2855	membrane
ACAN_1875	COG0583	DNA-binding transcription factor activity
ACAN_1877	COG1666	GTP binding
ACAN_1881	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACAN_1883	COG2363	Small membrane protein
ACAN_1885	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ACAN_1886	COG2252	PERMEase
ACAN_1888	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAN_1889	COG4977	sequence-specific DNA binding
ACAN_1890	COG3437	response regulator, receiver
ACAN_1890	COG0784	Response regulator, receiver
ACAN_1891	COG0640	Transcriptional regulator
ACAN_1892	COG2217	Heavy metal translocating P-type atpase
ACAN_1896	COG1979	alcohol dehydrogenase
ACAN_1898	COG1918	ferrous iron import across plasma membrane
ACAN_1899	COG1918	ferrous iron import across plasma membrane
ACAN_1899	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACAN_1904	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACAN_1925	COG4695	Portal protein
ACAN_1952	COG0731	radical SAM domain protein
ACAN_1953	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACAN_1955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACAN_1958	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACAN_1960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACAN_1962	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACAN_1963	COG0859	PFAM glycosyl transferase family 9
ACAN_1965	COG0515	serine threonine protein kinase
ACAN_1966	COG0859	PFAM glycosyl transferase family 9
ACAN_1968	COG2194	sulfuric ester hydrolase activity
ACAN_1970	COG0297	glycogen (starch) synthase activity
ACAN_1971	COG0463	Glycosyl transferase, family 2
ACAN_1978	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACAN_1980	COG0859	PFAM glycosyl transferase family 9
ACAN_1982	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACAN_1984	COG0493	'glutamate synthase
ACAN_1985	COG0067	glutamate synthase
ACAN_1985	COG0069	glutamate synthase activity
ACAN_1985	COG0070	glutamate synthase
ACAN_1993	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACAN_1996	COG1942	4-Oxalocrotonate Tautomerase
ACAN_2003	COG1472	Belongs to the glycosyl hydrolase 3 family
ACAN_2006	COG2116	formate transmembrane transporter activity
ACAN_2009	COG3260	NADH ubiquinone oxidoreductase 20
ACAN_2011	COG3261	NADH dehydrogenase
ACAN_2011	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ACAN_2012	COG0651	ATP synthesis coupled electron transport
ACAN_2013	COG4237	Hydrogenase 4 membrane
ACAN_2014	COG0650	Formate hydrogenlyase subunit 4
ACAN_2015	COG0651	ATP synthesis coupled electron transport
ACAN_2016	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACAN_2020	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACAN_2021	COG3842	ATPase activity
ACAN_2022	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACAN_2024	COG4662	Binding-protein-dependent transport system inner membrane component
ACAN_2025	COG2998	abc-type tungstate transport system, permease component
ACAN_2026	COG0303	'Molybdopterin
ACAN_2027	COG1104	cysteine desulfurase activity
ACAN_2030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACAN_2032	COG0437	4 iron, 4 sulfur cluster binding
ACAN_2039	COG2204	response regulator
ACAN_2042	COG1305	Transglutaminase-like
ACAN_2045	COG1921	L-seryl-tRNASec selenium transferase activity
ACAN_2048	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACAN_2051	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACAN_2052	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACAN_2053	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAN_2055	COG0840	transmembrane signaling receptor activity
ACAN_2056	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACAN_2058	COG0513	Belongs to the DEAD box helicase family
ACAN_2059	COG0840	transmembrane signaling receptor activity
ACAN_2060	COG0419	ATPase involved in DNA repair
ACAN_2068	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACAN_2069	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACAN_2070	COG1047	Peptidyl-prolyl cis-trans
ACAN_2073	COG0823	Involved in the tonB-independent uptake of proteins
ACAN_2075	COG0848	biopolymer transport protein
ACAN_2076	COG0811	peptide transport
ACAN_2077	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACAN_2078	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACAN_2079	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACAN_2080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACAN_2081	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACAN_2082	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACAN_2084	COG1475	DNA binding
ACAN_2085	COG1192	Involved in chromosome partitioning
ACAN_2088	COG4191	Histidine kinase
ACAN_2089	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACAN_2090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACAN_2091	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACAN_2092	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACAN_2093	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACAN_2094	COG0251	oxidation-reduction process
ACAN_2095	COG0358	DNA primase activity
ACAN_2097	COG0328	RNA-DNA hybrid ribonuclease activity
ACAN_2098	COG0571	ribonuclease III activity
ACAN_2099	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACAN_2101	COG1342	Belongs to the UPF0251 family
ACAN_2102	COG0501	Belongs to the peptidase M48B family
ACAN_2105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACAN_2107	COG0706	membrane insertase activity
ACAN_2108	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACAN_2110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACAN_2112	COG0542	response to heat
ACAN_2113	COG4191	Histidine kinase
ACAN_2115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACAN_2118	COG5001	Diguanylate cyclase
ACAN_2118	COG5002	protein histidine kinase activity
ACAN_2120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACAN_2120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACAN_2121	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACAN_2123	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACAN_2126	COG2610	gluconate transmembrane transporter activity
ACAN_2128	COG3118	belongs to the thioredoxin family
ACAN_2129	COG0450	alkyl hydroperoxide reductase
ACAN_2130	COG0028	Belongs to the TPP enzyme family
ACAN_2134	COG0745	RESPONSE REGULATOR receiver
ACAN_2134	COG3706	GGDEF domain
ACAN_2136	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACAN_2138	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ACAN_2142	COG0138	bifunctional purine biosynthesis protein purh
ACAN_2143	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACAN_2145	COG1196	nuclear chromosome segregation
ACAN_2145	COG0739	heme binding
ACAN_2145	COG0741	lytic transglycosylase activity
ACAN_2146	COG2239	Acts as a magnesium transporter
ACAN_2148	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAN_2151	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACAN_2158	COG0351	phosphomethylpyrimidine kinase
ACAN_2159	COG3279	Response regulator of the LytR AlgR family
ACAN_2160	COG3275	phosphorelay sensor kinase activity
ACAN_2162	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACAN_2164	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACAN_2165	COG0606	chelatase, subunit chli
ACAN_2167	COG0840	transmembrane signaling receptor activity
ACAN_2169	COG0242	peptide deformylase activity
ACAN_2170	COG0740	serine-type endopeptidase activity
ACAN_2171	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACAN_2175	COG2326	polyphosphate kinase activity
ACAN_2178	COG1773	rubredoxin
ACAN_2183	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACAN_2185	COG0840	transmembrane signaling receptor activity
ACAN_2187	COG0668	transmembrane transport
ACAN_2190	COG1271	oxidase subunit
ACAN_2192	COG1342	Belongs to the UPF0251 family
ACAN_2200	COG0716	FMN binding
ACAN_2201	COG0716	FMN binding
ACAN_2202	COG0716	FMN binding
ACAN_2211	COG3706	GGDEF domain
ACAN_2213	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACAN_2218	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACAN_2219	COG0159	tryptophan synthase activity
ACAN_2220	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACAN_2221	COG2255	four-way junction helicase activity
ACAN_2222	COG0628	permease
ACAN_2226	COG1518	maintenance of DNA repeat elements
ACAN_2234	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACAN_2235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACAN_2235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACAN_2237	COG0542	response to heat
ACAN_2238	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACAN_2239	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACAN_2242	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ACAN_2245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACAN_2247	COG1157	protein secretion by the type III secretion system
ACAN_2249	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACAN_2253	COG1677	Flagellar hook-basal body complex protein FliE
ACAN_2255	COG0455	bacterial-type flagellum organization
ACAN_2256	COG1419	protein localization to endoplasmic reticulum
ACAN_2259	COG3951	Flagellar rod assembly protein muramidase FlgJ
ACAN_2261	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACAN_2266	COG1749	Flagellar hook protein flgE
ACAN_2267	COG1749	Flagellar hook protein flgE
ACAN_2269	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACAN_2271	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACAN_2272	COG1766	The M ring may be actively involved in energy transduction
ACAN_2273	COG1815	bacterial-type flagellum-dependent cell motility
ACAN_2274	COG4786	Flagellar basal body rod
ACAN_2280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACAN_2282	COG0228	four-way junction DNA binding
ACAN_2283	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACAN_2285	COG1519	Transferase
ACAN_2287	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACAN_2288	COG0752	glycyl-tRNA synthetase alpha subunit
ACAN_2289	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACAN_2292	COG0840	transmembrane signaling receptor activity
ACAN_2292	COG0840	transmembrane signaling receptor activity
ACAN_2294	COG0497	DNA recombination
ACAN_2295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACAN_2296	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACAN_2297	COG0049	tRNA binding
ACAN_2298	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACAN_2299	COG2814	Major facilitator Superfamily
ACAN_2300	COG2267	carboxylic ester hydrolase activity
ACAN_2303	COG1671	Belongs to the UPF0178 family
ACAN_2304	COG4895	conserved protein (DUF2196)
ACAN_2314	COG3852	Histidine kinase
ACAN_2315	COG0745	RESPONSE REGULATOR receiver
ACAN_2318	COG2860	membrane
ACAN_2324	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACAN_2325	COG0085	RNA polymerase activity
ACAN_2326	COG0222	ribosome binding
ACAN_2327	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACAN_2328	COG0081	regulation of translation
ACAN_2329	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACAN_2330	COG0250	Participates in transcription elongation, termination and antitermination
ACAN_2333	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACAN_2334	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACAN_2339	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACAN_2340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACAN_2341	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACAN_2343	COG4172	Belongs to the ABC transporter superfamily
ACAN_2344	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACAN_2345	COG0174	glutamine synthetase
ACAN_2346	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACAN_2347	COG0745	RESPONSE REGULATOR receiver
ACAN_2347	COG3706	GGDEF domain
ACAN_2348	COG0314	molybdopterin synthase activity
ACAN_2350	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACAN_2351	COG1968	undecaprenyl-diphosphatase activity
ACAN_2353	COG0772	Belongs to the SEDS family
ACAN_2354	COG0768	penicillin binding
ACAN_2355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACAN_2364	COG0512	Glutamine amidotransferase of anthranilate synthase
ACAN_2366	COG1840	ABC-type Fe3 transport system, periplasmic component
ACAN_2368	COG3842	ATPase activity
ACAN_2369	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACAN_2370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACAN_2371	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_2372	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_2373	COG0649	NAD binding
ACAN_2373	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_2374	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ACAN_2376	COG0372	Belongs to the citrate synthase family
ACAN_2378	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACAN_2379	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_2380	COG0839	Belongs to the complex I subunit 6 family
ACAN_2381	COG0713	ATP synthesis coupled electron transport
ACAN_2382	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAN_2384	COG1007	ATP synthesis coupled electron transport
ACAN_2386	COG1053	succinate dehydrogenase
ACAN_2387	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACAN_2389	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ACAN_2390	COG1929	Belongs to the glycerate kinase type-1 family
ACAN_2393	COG0038	chloride channel
ACAN_2396	COG1012	belongs to the aldehyde dehydrogenase family
ACAN_2402	COG0494	nUDIX hydrolase
ACAN_2403	COG2095	MarC family integral membrane protein
ACAN_2404	COG0765	amino acid transport
ACAN_2408	COG0500	methyltransferase
ACAN_2410	COG1335	isochorismatase
ACAN_2412	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACAN_2413	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACAN_2414	COG0514	ATP-dependent DNA helicase (RecQ)
ACAN_2415	COG1280	lysine exporter protein (LysE YggA)
ACAN_2417	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACAN_2419	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACAN_2420	COG2828	Protein conserved in bacteria
ACAN_2422	COG0181	hydroxymethylbilane synthase activity
ACAN_2425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACAN_2428	COG0784	Response regulator, receiver
ACAN_2429	COG4774	siderophore transport
ACAN_2429	COG1629	transport
ACAN_2430	COG2382	esterase
ACAN_2431	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACAN_2432	COG0450	alkyl hydroperoxide reductase
ACAN_2434	COG0105	UTP biosynthetic process
ACAN_2436	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACAN_2437	COG0416	fatty acid biosynthetic process
ACAN_2438	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACAN_2440	COG1687	branched-chain amino acid
ACAN_2441	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACAN_2447	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACAN_2448	COG0540	Belongs to the ATCase OTCase family
ACAN_2449	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACAN_2452	COG0469	pyruvate kinase activity
ACAN_2456	COG2198	Histidine kinase
ACAN_2456	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAN_2456	COG0784	Response regulator, receiver
ACAN_2456	COG2205	protein histidine kinase activity
ACAN_2457	COG0745	RESPONSE REGULATOR receiver
ACAN_2459	COG0792	nuclease activity
ACAN_2460	COG0840	transmembrane signaling receptor activity
ACAN_2461	COG0156	8-amino-7-oxononanoate synthase activity
ACAN_2463	COG0288	reversible hydration of carbon dioxide
ACAN_2465	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACAN_2467	COG2121	Domain of unknown function (DUF374)
ACAN_2468	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAN_2470	COG0195	Participates in both transcription termination and antitermination
ACAN_2471	COG0215	cysteine-tRNA ligase activity
ACAN_2472	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACAN_2473	COG0629	single-stranded DNA binding
ACAN_2474	COG0360	Binds together with S18 to 16S ribosomal RNA
ACAN_2475	COG1466	dna polymerase III delta subunit
ACAN_2476	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACAN_2477	COG0557	exoribonuclease II activity
ACAN_2479	COG3852	Histidine kinase
ACAN_2480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACAN_2492	COG0640	Transcriptional regulator
ACAN_2496	COG3328	transposase activity
ACAN_2506	COG4974	Belongs to the 'phage' integrase family
ACAN_2510	COG5002	protein histidine kinase activity
ACAN_2511	COG0745	RESPONSE REGULATOR receiver
ACAN_2512	COG3301	Polysulphide reductase, NrfD
ACAN_2513	COG0437	4 iron, 4 sulfur cluster binding
ACAN_2517	COG0436	Aminotransferase
ACAN_2519	COG0343	queuine tRNA-ribosyltransferase activity
ACAN_2520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACAN_2521	COG1393	Belongs to the ArsC family
ACAN_2522	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACAN_2524	COG0560	Phosphoserine phosphatase
ACAN_2525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACAN_2525	COG0646	methionine synthase
ACAN_2526	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACAN_2527	COG0736	holo-[acyl-carrier-protein] synthase activity
ACAN_2528	COG0601	transmembrane transport
ACAN_2529	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACAN_2530	COG0745	RESPONSE REGULATOR receiver
ACAN_2531	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAN_2535	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ACAN_2536	COG4786	Flagellar basal body rod
ACAN_2536	COG1256	bacterial-type flagellum assembly
ACAN_2542	COG1987	bacterial-type flagellum assembly
ACAN_2544	COG1706	bacterial-type flagellum-dependent cell motility
ACAN_2545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACAN_2546	COG0418	dihydroorotase activity
ACAN_2548	COG0004	ammonium transporteR
ACAN_2549	COG0347	Belongs to the P(II) protein family
ACAN_2550	COG0004	ammonium transporteR
ACAN_2554	COG0204	Acyl-transferase
ACAN_2554	COG0318	PFAM AMP-dependent synthetase and ligase
ACAN_2555	COG0640	Transcriptional regulator
ACAN_2556	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ACAN_2560	COG0598	Magnesium transport protein CorA
ACAN_2561	COG0659	secondary active sulfate transmembrane transporter activity
ACAN_2563	COG2962	Rard protein
ACAN_2566	COG4536	flavin adenine dinucleotide binding
ACAN_2567	COG1346	cytolysis
ACAN_2568	COG1380	Effector of murein hydrolase LrgA
ACAN_2571	COG0745	RESPONSE REGULATOR receiver
ACAN_2572	COG3852	Histidine kinase
ACAN_2573	COG0252	asparaginase activity
ACAN_2574	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACAN_2575	COG1027	Aspartate ammonia-lyase
ACAN_2576	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACAN_2577	COG1053	succinate dehydrogenase
ACAN_2579	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACAN_2588	COG0628	permease
ACAN_2589	COG2205	protein histidine kinase activity
ACAN_2595	COG0129	dihydroxy-acid dehydratase activity
ACAN_2597	COG0745	RESPONSE REGULATOR receiver
ACAN_2598	COG5002	protein histidine kinase activity
ACAN_2599	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACAN_2600	COG3852	Histidine kinase
ACAN_2601	COG0745	RESPONSE REGULATOR receiver
ACAN_2604	COG1492	cobalamin metabolic process
ACAN_2605	COG1490	D-aminoacyl-tRNA deacylase activity
ACAN_2606	COG1401	restriction endodeoxyribonuclease activity
ACAN_2607	COG4804	nuclease activity
ACAN_2610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACAN_2611	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACAN_2613	COG2095	MarC family integral membrane protein
ACAN_2614	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACAN_2619	COG4232	protein-disulfide reductase activity
ACAN_2620	COG3118	belongs to the thioredoxin family
ACAN_2626	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACAN_2627	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACAN_2629	COG0443	Heat shock 70 kDa protein
ACAN_2630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACAN_2631	COG1420	regulation of RNA biosynthetic process
ACAN_2638	COG0745	RESPONSE REGULATOR receiver
ACAN_2640	COG0101	tRNA pseudouridine synthase activity
ACAN_2643	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACAN_2644	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACAN_2645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACAN_2648	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACAN_2661	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ACAN_2663	COG2089	acid synthase
ACAN_2664	COG2226	methyltransferase
ACAN_2668	COG3980	spore coat polysaccharide biosynthesis protein
ACAN_2669	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACAN_2671	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACAN_2672	COG1086	Polysaccharide biosynthesis protein
ACAN_2673	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACAN_2674	COG0148	phosphopyruvate hydratase activity
ACAN_2677	COG0475	glutathione-regulated potassium exporter activity
ACAN_2677	COG0569	domain protein
ACAN_2678	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACAN_2682	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACAN_2684	COG1007	ATP synthesis coupled electron transport
ACAN_2686	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAN_2687	COG0713	ATP synthesis coupled electron transport
ACAN_2688	COG0839	Belongs to the complex I subunit 6 family
ACAN_2689	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_2690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACAN_2694	COG0649	NAD binding
ACAN_2696	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_2697	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_2698	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAN_2702	COG0488	(ABC) transporter
ACAN_2703	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACAN_2705	COG3287	FIST C domain
ACAN_2705	COG2200	EAL domain
ACAN_2705	COG2199	diguanylate cyclase activity
ACAN_2707	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACAN_2709	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACAN_2710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACAN_2711	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACAN_2712	COG1077	Cell shape determining protein MreB Mrl
ACAN_2717	COG0445	tRNA wobble uridine modification
ACAN_2718	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ACAN_2720	COG0348	domain, Protein
ACAN_2721	COG0504	CTP synthase activity
ACAN_2722	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACAN_2726	COG0471	metal ion transport
ACAN_2729	COG0587	DNA-directed DNA polymerase activity
ACAN_2730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACAN_2735	COG0315	cyclic pyranopterin monophosphate synthase activity
ACAN_2736	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACAN_2737	COG0471	metal ion transport
ACAN_2738	COG0628	permease
ACAN_2745	COG0670	Belongs to the BI1 family
ACAN_2746	COG0352	thiamine-phosphate diphosphorylase activity
ACAN_2748	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACAN_2750	COG0233	cytoplasmic translational termination
ACAN_2751	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACAN_2753	COG2814	Major facilitator Superfamily
ACAN_2754	COG3022	response to hydroperoxide
ACAN_2755	COG3012	SEC-C Motif Domain Protein
ACAN_2758	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACAN_2759	COG1704	LemA family
ACAN_2767	COG0415	Belongs to the DNA photolyase family
ACAN_2768	COG2081	HI0933 family
ACAN_2771	COG1959	2 iron, 2 sulfur cluster binding
ACAN_2774	COG0175	sulfate reduction
ACAN_2775	COG0175	sulfate reduction
ACAN_2776	COG2895	sulfate adenylyltransferase (ATP) activity
ACAN_2777	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACAN_2778	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACAN_2779	COG0840	transmembrane signaling receptor activity
ACAN_2780	COG1408	metallophosphoesterase
ACAN_2784	COG2391	methyltransferase activity
ACAN_2785	COG0425	Belongs to the sulfur carrier protein TusA family
ACAN_2786	COG2066	Belongs to the glutaminase family
ACAN_2787	COG2860	membrane
ACAN_2788	COG0840	transmembrane signaling receptor activity
ACAN_2789	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACAN_2790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group