locus-tag	class	description
ACLO_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACLO_0002	COG0592	DNA-directed DNA polymerase activity
ACLO_0003	COG0187	DNA topoisomerase II activity
ACLO_0004	COG0492	ferredoxin-NADP+ reductase activity
ACLO_0005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACLO_0008	COG1238	metal cluster binding
ACLO_0009	COG0477	Major facilitator Superfamily
ACLO_0010	COG0564	pseudouridine synthase activity
ACLO_0011	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACLO_0012	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACLO_0013	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACLO_0018	COG2954	triphosphatase activity
ACLO_0019	COG1151	hydroxylamine reductase activity
ACLO_0021	COG0493	'glutamate synthase
ACLO_0023	COG0052	Belongs to the universal ribosomal protein uS2 family
ACLO_0024	COG0604	alcohol dehydrogenase
ACLO_0026	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACLO_0027	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACLO_0030	COG0745	RESPONSE REGULATOR receiver
ACLO_0031	COG4191	Histidine kinase
ACLO_0032	COG1556	Lactate utilization protein
ACLO_0033	COG1139	Iron-sulfur cluster binding protein
ACLO_0034	COG0247	lactate metabolic process
ACLO_0036	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACLO_0037	COG0511	ligase activity, forming carbon-carbon bonds
ACLO_0038	COG0439	Biotin carboxylase
ACLO_0039	COG0513	Belongs to the DEAD box helicase family
ACLO_0040	COG0306	phosphate transporter
ACLO_0042	COG0367	asparagine synthase
ACLO_0044	COG0778	Nitroreductase
ACLO_0046	COG1053	succinate dehydrogenase
ACLO_0048	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACLO_0050	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ACLO_0050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACLO_0051	COG1187	pseudouridine synthase activity
ACLO_0052	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACLO_0052	COG0517	IMP dehydrogenase activity
ACLO_0054	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACLO_0055	COG0107	imidazoleglycerol-phosphate synthase activity
ACLO_0058	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACLO_0059	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACLO_0060	COG0724	RNA recognition motif
ACLO_0061	COG0745	RESPONSE REGULATOR receiver
ACLO_0062	COG0642	Histidine kinase
ACLO_0063	COG3706	GGDEF domain
ACLO_0067	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACLO_0068	COG2353	YceI-like domain
ACLO_0070	COG0534	Mate efflux family protein
ACLO_0071	COG0460	homoserine dehydrogenase
ACLO_0072	COG0436	Aminotransferase
ACLO_0075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACLO_0076	COG0254	rRNA binding
ACLO_0077	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACLO_0103	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACLO_0104	COG1705	Flagellar rod assembly protein muramidase FlgJ
ACLO_0104	COG3951	Flagellar rod assembly protein muramidase FlgJ
ACLO_0105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACLO_0106	COG0237	dephospho-CoA kinase activity
ACLO_0107	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACLO_0108	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACLO_0109	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACLO_0111	COG3384	dioxygenase
ACLO_0113	COG1846	Transcriptional regulator
ACLO_0114	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACLO_0115	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACLO_0116	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACLO_0118	COG0505	Belongs to the CarA family
ACLO_0121	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACLO_0121	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACLO_0124	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACLO_0125	COG0489	protein tyrosine kinase activity
ACLO_0127	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACLO_0127	COG0140	phosphoribosyl-ATP diphosphatase activity
ACLO_0131	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACLO_0132	COG0840	transmembrane signaling receptor activity
ACLO_0134	COG1410	methionine synthase
ACLO_0134	COG0646	methionine synthase
ACLO_0135	COG0450	alkyl hydroperoxide reductase
ACLO_0138	COG1979	alcohol dehydrogenase
ACLO_0139	COG4191	Histidine kinase
ACLO_0141	COG1686	Belongs to the peptidase S11 family
ACLO_0144	COG1854	S-ribosylhomocysteine lyase activity
ACLO_0149	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACLO_0150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACLO_0153	COG3180	Ammonia monooxygenase
ACLO_0154	COG1733	regulation of RNA biosynthetic process
ACLO_0155	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACLO_0156	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACLO_0157	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACLO_0159	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACLO_0160	COG0546	phosphoglycolate phosphatase activity
ACLO_0162	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACLO_0163	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACLO_0165	COG0745	RESPONSE REGULATOR receiver
ACLO_0167	COG0704	Plays a role in the regulation of phosphate uptake
ACLO_0168	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACLO_0169	COG0581	inorganic phosphate transmembrane transporter activity
ACLO_0170	COG0573	inorganic phosphate transmembrane transporter activity
ACLO_0171	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACLO_0173	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACLO_0174	COG0268	Binds directly to 16S ribosomal RNA
ACLO_0175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACLO_0176	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACLO_0177	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACLO_0179	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACLO_0182	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACLO_0183	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACLO_0184	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACLO_0190	COG0575	Belongs to the CDS family
ACLO_0191	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACLO_0195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACLO_0197	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACLO_0197	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACLO_0198	COG1324	tolerance protein
ACLO_0199	COG2022	thiamine diphosphate biosynthetic process
ACLO_0207	COG1002	Type II restriction enzyme, methylase subunits
ACLO_0210	COG3177	Filamentation induced by cAMP protein fic
ACLO_0211	COG1061	Type III restriction enzyme res subunit
ACLO_0212	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACLO_0216	COG0745	RESPONSE REGULATOR receiver
ACLO_0219	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACLO_0220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACLO_0222	COG1742	UPF0060 membrane protein
ACLO_0223	COG2217	Heavy metal translocating P-type atpase
ACLO_0232	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACLO_0233	COG0745	RESPONSE REGULATOR receiver
ACLO_0243	COG2217	Heavy metal translocating P-type atpase
ACLO_0247	COG2132	Multicopper oxidase
ACLO_0253	COG0628	permease
ACLO_0254	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACLO_0258	COG1968	undecaprenyl-diphosphatase activity
ACLO_0285	COG0582	viral genome integration into host DNA
ACLO_0289	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ACLO_0290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACLO_0294	COG0840	transmembrane signaling receptor activity
ACLO_0303	COG4191	Histidine kinase
ACLO_0304	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACLO_0308	COG1346	cytolysis
ACLO_0313	COG0659	secondary active sulfate transmembrane transporter activity
ACLO_0319	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACLO_0321	COG3290	protein histidine kinase activity
ACLO_0324	COG0004	ammonium transporteR
ACLO_0325	COG0347	Belongs to the P(II) protein family
ACLO_0326	COG0004	ammonium transporteR
ACLO_0328	COG0418	dihydroorotase activity
ACLO_0330	COG1706	bacterial-type flagellum-dependent cell motility
ACLO_0337	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ACLO_0338	COG1256	bacterial-type flagellum assembly
ACLO_0338	COG4786	Flagellar basal body rod
ACLO_0339	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ACLO_0343	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACLO_0344	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACLO_0345	COG0601	transmembrane transport
ACLO_0346	COG0736	holo-[acyl-carrier-protein] synthase activity
ACLO_0348	COG0560	Phosphoserine phosphatase
ACLO_0349	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACLO_0350	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACLO_0351	COG3248	Nucleoside-binding outer membrane protein
ACLO_0352	COG1393	Belongs to the ArsC family
ACLO_0353	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACLO_0354	COG0343	queuine tRNA-ribosyltransferase activity
ACLO_0356	COG0436	Aminotransferase
ACLO_0360	COG2861	carbohydrate metabolic process
ACLO_0361	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACLO_0362	COG0557	exoribonuclease II activity
ACLO_0364	COG0360	Binds together with S18 to 16S ribosomal RNA
ACLO_0365	COG0629	single-stranded DNA binding
ACLO_0366	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACLO_0368	COG0215	cysteine-tRNA ligase activity
ACLO_0369	COG0195	Participates in both transcription termination and antitermination
ACLO_0371	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACLO_0372	COG2121	Domain of unknown function (DUF374)
ACLO_0374	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACLO_0376	COG0288	reversible hydration of carbon dioxide
ACLO_0377	COG0156	8-amino-7-oxononanoate synthase activity
ACLO_0378	COG0792	nuclease activity
ACLO_0382	COG0469	pyruvate kinase activity
ACLO_0383	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACLO_0385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACLO_0387	COG0540	Belongs to the ATCase OTCase family
ACLO_0388	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACLO_0389	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACLO_0392	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACLO_0393	COG1687	branched-chain amino acid
ACLO_0394	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACLO_0395	COG0416	fatty acid biosynthetic process
ACLO_0396	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACLO_0398	COG0105	UTP biosynthetic process
ACLO_0400	COG0450	alkyl hydroperoxide reductase
ACLO_0401	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACLO_0402	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACLO_0403	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACLO_0404	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACLO_0406	COG0181	hydroxymethylbilane synthase activity
ACLO_0408	COG5001	Diguanylate cyclase
ACLO_0409	COG2828	Protein conserved in bacteria
ACLO_0410	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACLO_0412	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACLO_0414	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACLO_0419	COG0514	ATP-dependent DNA helicase (RecQ)
ACLO_0420	COG0500	methyltransferase
ACLO_0423	COG1451	nucleotide metabolic process
ACLO_0426	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACLO_0427	COG1053	succinate dehydrogenase
ACLO_0429	COG1007	ATP synthesis coupled electron transport
ACLO_0431	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACLO_0432	COG0713	ATP synthesis coupled electron transport
ACLO_0434	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_0435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACLO_0436	COG1034	ATP synthesis coupled electron transport
ACLO_0437	COG0372	Belongs to the citrate synthase family
ACLO_0440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_0440	COG0649	NAD binding
ACLO_0441	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_0442	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_0443	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACLO_0444	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACLO_0445	COG3610	response to peptide
ACLO_0446	COG2966	Psort location CytoplasmicMembrane, score
ACLO_0448	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACLO_0449	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACLO_0452	COG3706	GGDEF domain
ACLO_0456	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACLO_0459	COG0840	transmembrane signaling receptor activity
ACLO_0463	COG3043	anaerobic respiration
ACLO_0464	COG0348	domain, Protein
ACLO_0465	COG0437	4 iron, 4 sulfur cluster binding
ACLO_0466	COG0243	molybdopterin cofactor binding
ACLO_0471	COG2204	response regulator
ACLO_0472	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACLO_0476	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACLO_0477	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACLO_0480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACLO_0481	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACLO_0482	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACLO_0483	COG1959	2 iron, 2 sulfur cluster binding
ACLO_0484	COG2404	hydrolase activity, acting on ester bonds
ACLO_0486	COG0642	Histidine kinase
ACLO_0487	COG0745	RESPONSE REGULATOR receiver
ACLO_0489	COG0191	fructose-bisphosphate aldolase activity
ACLO_0490	COG3842	ATPase activity
ACLO_0492	COG1177	transmembrane transport
ACLO_0493	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACLO_0494	COG1278	Cold shock
ACLO_0496	COG0811	peptide transport
ACLO_0498	COG4191	Histidine kinase
ACLO_0500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACLO_0501	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACLO_0503	COG0142	geranyltranstransferase activity
ACLO_0504	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACLO_0505	COG0442	prolyl-tRNA aminoacylation
ACLO_0506	COG0668	transmembrane transport
ACLO_0507	COG0617	tRNA 3'-terminal CCA addition
ACLO_0511	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACLO_0512	COG1862	Preprotein translocase
ACLO_0513	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACLO_0514	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACLO_0516	COG0495	leucyl-tRNA aminoacylation
ACLO_0518	COG0285	dihydrofolate synthase activity
ACLO_0533	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACLO_0535	COG5001	Diguanylate cyclase
ACLO_0535	COG4251	negative regulation of phosphorylation
ACLO_0535	COG3706	GGDEF domain
ACLO_0535	COG2203	Gaf domain
ACLO_0537	COG0745	RESPONSE REGULATOR receiver
ACLO_0538	COG0642	Histidine kinase
ACLO_0539	COG2081	HI0933 family
ACLO_0540	COG0840	transmembrane signaling receptor activity
ACLO_0542	COG3920	Histidine kinase
ACLO_0543	COG5000	phosphorelay sensor kinase activity
ACLO_0544	COG1692	metallophosphoesterase
ACLO_0547	COG2226	methyltransferase
ACLO_0548	COG1570	exodeoxyribonuclease VII activity
ACLO_0551	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACLO_0553	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACLO_0554	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACLO_0557	COG0459	protein refolding
ACLO_0559	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACLO_0562	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACLO_0563	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACLO_0564	COG0352	thiamine-phosphate diphosphorylase activity
ACLO_0565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACLO_0567	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACLO_0568	COG2264	protein methyltransferase activity
ACLO_0569	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACLO_0570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACLO_0573	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACLO_0576	COG1320	monovalent cation:proton antiporter activity
ACLO_0580	COG1007	ATP synthesis coupled electron transport
ACLO_0581	COG0651	ATP synthesis coupled electron transport
ACLO_0582	COG0651	ATP synthesis coupled electron transport
ACLO_0583	COG3706	GGDEF domain
ACLO_0584	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACLO_0585	COG1090	epimerase
ACLO_0586	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACLO_0598	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACLO_0599	COG0732	type I restriction modification DNA specificity domain
ACLO_0602	COG3177	Filamentation induced by cAMP protein fic
ACLO_0603	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACLO_0610	COG0481	GTPase activity
ACLO_0613	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACLO_0616	COG0482	sulfurtransferase activity
ACLO_0617	COG0482	sulfurtransferase activity
ACLO_0618	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACLO_0619	COG0006	proline dipeptidase activity
ACLO_0620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACLO_0621	COG0402	S-adenosylhomocysteine deaminase activity
ACLO_0622	COG0616	signal peptide processing
ACLO_0624	COG0280	phosphate acetyltransferase
ACLO_0625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACLO_0627	COG2176	DNA-directed DNA polymerase activity
ACLO_0631	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACLO_0633	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACLO_0635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACLO_0637	COG0745	RESPONSE REGULATOR receiver
ACLO_0638	COG5002	protein histidine kinase activity
ACLO_0647	COG1546	Belongs to the CinA family
ACLO_0647	COG1058	Belongs to the CinA family
ACLO_0648	COG0579	oxidoreductase
ACLO_0649	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACLO_0653	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACLO_0658	COG0714	Associated with various cellular activities
ACLO_0659	COG0052	Belongs to the universal ribosomal protein uS2 family
ACLO_0660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACLO_0661	COG1136	(ABC) transporter
ACLO_0663	COG0194	GDP metabolic process
ACLO_0664	COG5001	Diguanylate cyclase
ACLO_0664	COG5002	protein histidine kinase activity
ACLO_0665	COG2217	Heavy metal translocating P-type atpase
ACLO_0668	COG4608	Belongs to the ABC transporter superfamily
ACLO_0669	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACLO_0670	COG2078	PFAM AMMECR1 domain protein
ACLO_0671	COG1355	regulation of microtubule-based process
ACLO_0672	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACLO_0673	COG1121	(ABC) transporter
ACLO_0674	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACLO_0676	COG1283	sodium-dependent phosphate transmembrane transporter activity
ACLO_0678	COG2996	Protein conserved in bacteria
ACLO_0679	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACLO_0682	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACLO_0683	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACLO_0687	COG0210	DNA helicase
ACLO_0688	COG0569	domain protein
ACLO_0688	COG0475	glutathione-regulated potassium exporter activity
ACLO_0689	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACLO_0694	COG3258	Cytochrome c
ACLO_0697	COG1331	Highly conserved protein containing a thioredoxin domain
ACLO_0707	COG0525	valine-tRNA ligase activity
ACLO_0709	COG0454	-acetyltransferase
ACLO_0711	COG4895	conserved protein (DUF2196)
ACLO_0712	COG1047	Peptidyl-prolyl cis-trans
ACLO_0713	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACLO_0717	COG3706	GGDEF domain
ACLO_0719	COG2814	Major facilitator Superfamily
ACLO_0720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACLO_0724	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACLO_0725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACLO_0726	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACLO_0736	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACLO_0740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACLO_0744	COG3706	GGDEF domain
ACLO_0746	COG0439	Biotin carboxylase
ACLO_0747	COG0840	transmembrane signaling receptor activity
ACLO_0748	COG0840	transmembrane signaling receptor activity
ACLO_0754	COG2166	iron-sulfur cluster assembly
ACLO_0755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACLO_0757	COG0396	ATPase activity
ACLO_0758	COG0719	Fe-S assembly protein
ACLO_0760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACLO_0760	COG0822	iron-sulfur transferase activity
ACLO_0760	COG2906	2 iron, 2 sulfur cluster binding
ACLO_0762	COG2239	Acts as a magnesium transporter
ACLO_0768	COG0165	Argininosuccinate lyase
ACLO_0769	COG0835	chemotaxis
ACLO_0769	COG0784	Response regulator, receiver
ACLO_0770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACLO_0771	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACLO_0772	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACLO_0775	COG0556	nucleotide-excision repair
ACLO_0783	COG0698	ribose 5-phosphate isomerase
ACLO_0784	COG0681	Belongs to the peptidase S26 family
ACLO_0785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACLO_0786	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACLO_0787	COG0193	aminoacyl-tRNA hydrolase activity
ACLO_0792	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACLO_0794	COG1758	RNA polymerase activity
ACLO_0795	COG0528	UMP kinase activity
ACLO_0797	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACLO_0798	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACLO_0799	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACLO_0801	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACLO_0802	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACLO_0805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACLO_0807	COG0305	Participates in initiation and elongation during chromosome replication
ACLO_0809	COG1793	dna ligase
ACLO_0810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACLO_0811	COG0133	tryptophan synthase activity
ACLO_0813	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACLO_0815	COG0848	biopolymer transport protein
ACLO_0819	COG1136	(ABC) transporter
ACLO_0819	COG0577	efflux transmembrane transporter activity
ACLO_0820	COG0577	efflux transmembrane transporter activity
ACLO_0820	COG1136	(ABC) transporter
ACLO_0824	COG1082	Xylose isomerase domain protein TIM barrel
ACLO_0838	COG0735	belongs to the Fur family
ACLO_0841	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACLO_0841	COG1918	ferrous iron import across plasma membrane
ACLO_0842	COG1918	ferrous iron import across plasma membrane
ACLO_0847	COG4774	siderophore transport
ACLO_0848	COG3128	pkhd-type hydroxylase
ACLO_0850	COG4771	TonB-dependent receptor
ACLO_0853	COG1366	Belongs to the anti-sigma-factor antagonist family
ACLO_0853	COG2202	Pas domain
ACLO_0855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACLO_0856	COG0585	pseudouridine synthase activity
ACLO_0859	COG0632	four-way junction helicase activity
ACLO_0860	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACLO_0861	COG2267	carboxylic ester hydrolase activity
ACLO_0862	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACLO_0865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACLO_0866	COG0051	transcription antitermination factor activity, RNA binding
ACLO_0867	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACLO_0868	COG0088	Forms part of the polypeptide exit tunnel
ACLO_0869	COG0089	rRNA binding
ACLO_0870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACLO_0871	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACLO_0872	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACLO_0873	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACLO_0874	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACLO_0875	COG0255	Belongs to the universal ribosomal protein uL29 family
ACLO_0876	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACLO_0877	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACLO_0878	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACLO_0879	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACLO_0880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACLO_0881	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACLO_0882	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACLO_0883	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACLO_0884	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACLO_0885	COG0200	Binds to the 23S rRNA
ACLO_0886	COG0201	protein transport
ACLO_0887	COG0024	Methionine aminopeptidase
ACLO_0888	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACLO_0890	COG1573	uracil-dna glycosylase
ACLO_0892	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACLO_0895	COG1032	radical SAM domain protein
ACLO_0897	COG0563	adenylate kinase activity
ACLO_0906	COG0829	nickel cation binding
ACLO_0907	COG0831	urea catabolic process
ACLO_0907	COG0832	Belongs to the urease beta subunit family
ACLO_0908	COG0804	urea catabolic process
ACLO_0909	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ACLO_0911	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACLO_0916	COG3706	GGDEF domain
ACLO_0917	COG0708	Exodeoxyribonuclease III
ACLO_0923	COG0166	Belongs to the GPI family
ACLO_0932	COG3123	guanosine phosphorylase activity
ACLO_0936	COG0012	GTP binding
ACLO_0937	COG2252	PERMEase
ACLO_0938	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ACLO_0939	COG2363	Small membrane protein
ACLO_0941	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACLO_0942	COG2233	PERMEase
ACLO_0943	COG1666	GTP binding
ACLO_0945	COG0745	RESPONSE REGULATOR receiver
ACLO_0946	COG0642	Histidine kinase
ACLO_0950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACLO_0951	COG0135	phosphoribosylanthranilate isomerase activity
ACLO_0952	COG2176	DNA-directed DNA polymerase activity
ACLO_0953	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACLO_0955	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACLO_0956	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACLO_0956	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACLO_0958	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACLO_0959	COG0727	PFAM Uncharacterised protein family (UPF0153)
ACLO_0961	COG0134	indole-3-glycerol-phosphate synthase activity
ACLO_0962	COG0583	DNA-binding transcription factor activity
ACLO_0963	COG1942	4-Oxalocrotonate Tautomerase
ACLO_0965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACLO_0966	COG0750	zinc metalloprotease
ACLO_0967	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACLO_0968	COG1028	Short-chain dehydrogenase reductase Sdr
ACLO_0969	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACLO_0972	COG0167	dihydroorotate dehydrogenase activity
ACLO_0973	COG1132	(ABC) transporter
ACLO_0974	COG0728	peptidoglycan biosynthetic process
ACLO_0976	COG1592	Rubrerythrin
ACLO_0978	COG0530	calcium, potassium:sodium antiporter activity
ACLO_0979	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACLO_0980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACLO_0988	COG0552	protein localization to endoplasmic reticulum
ACLO_0989	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACLO_0991	COG1418	mRNA catabolic process
ACLO_0992	COG0742	ribosomal rna small subunit methyltransferase
ACLO_0993	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACLO_0995	COG0300	oxidoreductase activity
ACLO_0998	COG3258	Cytochrome c
ACLO_1001	COG0642	Histidine kinase
ACLO_1003	COG0157	Belongs to the NadC ModD family
ACLO_1005	COG1610	YqeY-like protein
ACLO_1008	COG0428	transporter
ACLO_1009	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACLO_1010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACLO_1011	COG0436	Aminotransferase
ACLO_1012	COG1451	nucleotide metabolic process
ACLO_1014	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACLO_1015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACLO_1015	COG0519	Catalyzes the synthesis of GMP from XMP
ACLO_1018	COG2336	PFAM SpoVT AbrB
ACLO_1021	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACLO_1029	COG0596	Alpha beta hydrolase
ACLO_1030	COG1489	DNA binding
ACLO_1033	COG1696	Membrane protein involved in D-alanine export
ACLO_1034	COG0564	pseudouridine synthase activity
ACLO_1035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACLO_1037	COG2223	nitrite transmembrane transporter activity
ACLO_1041	COG0300	oxidoreductase activity
ACLO_1042	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACLO_1042	COG0519	Catalyzes the synthesis of GMP from XMP
ACLO_1054	COG2989	Protein conserved in bacteria
ACLO_1055	COG0628	permease
ACLO_1056	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACLO_1059	COG4536	flavin adenine dinucleotide binding
ACLO_1062	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACLO_1063	COG1309	transcriptional regulator
ACLO_1066	COG0513	Belongs to the DEAD box helicase family
ACLO_1068	COG1045	serine acetyltransferase
ACLO_1069	COG1166	arginine decarboxylase activity
ACLO_1070	COG0124	histidyl-tRNA synthetase
ACLO_1071	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACLO_1072	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACLO_1073	COG0163	prenyltransferase activity
ACLO_1075	COG0359	binds to the 23S rRNA
ACLO_1076	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACLO_1077	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACLO_1079	COG0084	hydrolase, TatD family'
ACLO_1081	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACLO_1082	COG0131	Imidazoleglycerol-phosphate dehydratase
ACLO_1083	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACLO_1086	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACLO_1087	COG0456	acetyltransferase
ACLO_1088	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACLO_1089	COG3576	pyridoxamine 5-phosphate
ACLO_1093	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACLO_1095	COG2897	thiosulfate sulfurtransferase activity
ACLO_1097	COG1338	Plays a role in the flagellum-specific transport system
ACLO_1108	COG0849	cell division
ACLO_1109	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACLO_1112	COG0408	coproporphyrinogen oxidase activity
ACLO_1114	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACLO_1116	COG1193	negative regulation of DNA recombination
ACLO_1120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACLO_1124	COG1396	sequence-specific DNA binding
ACLO_1125	COG1119	ATPase activity
ACLO_1128	COG0077	Prephenate dehydratase
ACLO_1128	COG1605	Chorismate mutase
ACLO_1129	COG2824	Alkylphosphonate utilization operon protein PhnA
ACLO_1133	COG1881	PFAM PEBP family protein
ACLO_1134	COG0583	DNA-binding transcription factor activity
ACLO_1135	COG2855	membrane
ACLO_1140	COG1733	regulation of RNA biosynthetic process
ACLO_1141	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACLO_1144	COG0778	Nitroreductase
ACLO_1146	COG5002	protein histidine kinase activity
ACLO_1152	COG2198	Histidine kinase
ACLO_1152	COG0643	Histidine kinase
ACLO_1155	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
ACLO_1158	COG0784	Response regulator, receiver
ACLO_1158	COG3437	response regulator, receiver
ACLO_1160	COG3040	lipid binding
ACLO_1163	COG3046	protein related to deoxyribodipyrimidine photolyase
ACLO_1166	COG3287	FIST C domain
ACLO_1166	COG2200	EAL domain
ACLO_1166	COG2199	diguanylate cyclase activity
ACLO_1168	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACLO_1171	COG3040	lipid binding
ACLO_1172	COG2211	Major facilitator Superfamily
ACLO_1173	COG0300	oxidoreductase activity
ACLO_1175	COG0488	(ABC) transporter
ACLO_1176	COG1607	acyl-coa hydrolase
ACLO_1177	COG0784	Response regulator, receiver
ACLO_1177	COG3437	response regulator, receiver
ACLO_1178	COG0840	transmembrane signaling receptor activity
ACLO_1179	COG0840	transmembrane signaling receptor activity
ACLO_1180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACLO_1202	COG0393	Putative heavy-metal-binding
ACLO_1213	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACLO_1215	COG0745	RESPONSE REGULATOR receiver
ACLO_1216	COG1333	cytochrome c biogenesis protein
ACLO_1216	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACLO_1222	COG0582	viral genome integration into host DNA
ACLO_1223	COG0500	methyltransferase
ACLO_1224	COG5001	Diguanylate cyclase
ACLO_1224	COG3706	GGDEF domain
ACLO_1224	COG2203	Gaf domain
ACLO_1224	COG4251	negative regulation of phosphorylation
ACLO_1225	COG5001	Diguanylate cyclase
ACLO_1226	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACLO_1230	COG0133	tryptophan synthase activity
ACLO_1231	COG0484	heat shock protein binding
ACLO_1232	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACLO_1237	COG0137	argininosuccinate synthase activity
ACLO_1239	COG4771	TonB-dependent receptor
ACLO_1241	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACLO_1242	COG0802	atpase or kinase
ACLO_1243	COG1137	ATPase activity
ACLO_1244	COG3706	GGDEF domain
ACLO_1245	COG2199	diguanylate cyclase activity
ACLO_1245	COG2200	EAL domain
ACLO_1245	COG3287	FIST C domain
ACLO_1246	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACLO_1247	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACLO_1247	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACLO_1251	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACLO_1252	COG2181	nitrate reductase activity
ACLO_1252	COG0247	lactate metabolic process
ACLO_1254	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACLO_1260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACLO_1261	COG0805	protein transport
ACLO_1262	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACLO_1263	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACLO_1267	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACLO_1269	COG1663	tetraacyldisaccharide 4'-kinase activity
ACLO_1271	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACLO_1272	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACLO_1273	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACLO_1273	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACLO_1276	COG0745	RESPONSE REGULATOR receiver
ACLO_1277	COG0840	transmembrane signaling receptor activity
ACLO_1278	COG0113	porphobilinogen synthase activity
ACLO_1279	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACLO_1280	COG0357	Ribosomal RNA small subunit methyltransferase G
ACLO_1286	COG0745	RESPONSE REGULATOR receiver
ACLO_1288	COG0330	HflC and HflK could
ACLO_1297	COG0848	biopolymer transport protein
ACLO_1300	COG0419	ATPase involved in DNA repair
ACLO_1309	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACLO_1310	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ACLO_1311	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACLO_1312	COG1187	pseudouridine synthase activity
ACLO_1319	COG4206	TonB-dependent receptor
ACLO_1322	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACLO_1327	COG0667	Aldo Keto reductase
ACLO_1328	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACLO_1329	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACLO_1331	COG0280	phosphate acetyltransferase
ACLO_1331	COG0281	malic enzyme
ACLO_1332	COG0788	formyltetrahydrofolate deformylase activity
ACLO_1333	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACLO_1339	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACLO_1340	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ACLO_1341	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACLO_1345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACLO_1345	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACLO_1347	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACLO_1353	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACLO_1354	COG0612	Peptidase, M16
ACLO_1355	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACLO_1356	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACLO_1357	COG0287	Prephenate dehydrogenase
ACLO_1358	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACLO_1361	COG0527	aspartate kinase activity
ACLO_1362	COG0494	nUDIX hydrolase
ACLO_1363	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACLO_1364	COG2890	protein-(glutamine-N5) methyltransferase activity
ACLO_1365	COG0339	signal peptide processing
ACLO_1374	COG0582	viral genome integration into host DNA
ACLO_1375	COG2201	protein-glutamate methylesterase activity
ACLO_1377	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACLO_1378	COG0643	Histidine kinase
ACLO_1378	COG2198	Histidine kinase
ACLO_1380	COG1185	polyribonucleotide nucleotidyltransferase activity
ACLO_1382	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACLO_1386	COG0659	secondary active sulfate transmembrane transporter activity
ACLO_1387	COG1160	GTP binding
ACLO_1389	COG1674	ftsk spoiiie
ACLO_1389	COG1196	nuclear chromosome segregation
ACLO_1390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACLO_1391	COG0440	acetolactate synthase activity
ACLO_1392	COG0028	Belongs to the TPP enzyme family
ACLO_1393	COG3300	MHYT domain
ACLO_1393	COG5001	Diguanylate cyclase
ACLO_1398	COG2203	Gaf domain
ACLO_1398	COG4251	negative regulation of phosphorylation
ACLO_1398	COG5001	Diguanylate cyclase
ACLO_1398	COG3706	GGDEF domain
ACLO_1403	COG0037	tRNA processing
ACLO_1408	COG1322	Protein conserved in bacteria
ACLO_1409	COG0501	Belongs to the peptidase M48B family
ACLO_1411	COG0824	Thioesterase
ACLO_1413	COG4191	Histidine kinase
ACLO_1414	COG3437	response regulator, receiver
ACLO_1414	COG0784	Response regulator, receiver
ACLO_1415	COG0840	transmembrane signaling receptor activity
ACLO_1416	COG0840	transmembrane signaling receptor activity
ACLO_1418	COG0745	RESPONSE REGULATOR receiver
ACLO_1420	COG2205	protein histidine kinase activity
ACLO_1420	COG3850	Histidine kinase
ACLO_1420	COG4999	Histidine kinase
ACLO_1420	COG3437	response regulator, receiver
ACLO_1421	COG0840	transmembrane signaling receptor activity
ACLO_1424	COG2059	Chromate
ACLO_1425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACLO_1428	COG0640	Transcriptional regulator
ACLO_1430	COG0754	glutathionylspermidine amidase activity
ACLO_1431	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACLO_1431	COG4191	Histidine kinase
ACLO_1432	COG1879	ABC-type sugar transport system periplasmic component
ACLO_1436	COG0653	protein targeting
ACLO_1437	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACLO_1441	COG0039	L-malate dehydrogenase activity
ACLO_1444	COG4865	methylaspartate mutase activity
ACLO_1446	COG0318	PFAM AMP-dependent synthetase and ligase
ACLO_1452	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACLO_1456	COG0275	rRNA processing
ACLO_1458	COG0776	regulation of translation
ACLO_1461	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACLO_1461	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACLO_1463	COG2201	protein-glutamate methylesterase activity
ACLO_1466	COG0484	heat shock protein binding
ACLO_1467	COG0789	Transcriptional regulator
ACLO_1468	COG4974	Belongs to the 'phage' integrase family
ACLO_1483	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACLO_1484	COG1280	lysine exporter protein (LysE YggA)
ACLO_1485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACLO_1486	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ACLO_1488	COG0471	metal ion transport
ACLO_1489	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACLO_1491	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACLO_1492	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACLO_1494	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACLO_1496	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACLO_1502	COG3279	Response regulator of the LytR AlgR family
ACLO_1514	COG0642	Histidine kinase
ACLO_1515	COG0745	RESPONSE REGULATOR receiver
ACLO_1519	COG1132	(ABC) transporter
ACLO_1520	COG0628	permease
ACLO_1522	COG3300	MHYT domain
ACLO_1522	COG5001	Diguanylate cyclase
ACLO_1523	COG3118	belongs to the thioredoxin family
ACLO_1524	COG0450	alkyl hydroperoxide reductase
ACLO_1525	COG5002	protein histidine kinase activity
ACLO_1525	COG0784	Response regulator, receiver
ACLO_1525	COG2205	protein histidine kinase activity
ACLO_1527	COG1472	Belongs to the glycosyl hydrolase 3 family
ACLO_1532	COG1620	l-lactate permease
ACLO_1533	COG0484	heat shock protein binding
ACLO_1539	COG2204	response regulator
ACLO_1540	COG0784	Response regulator, receiver
ACLO_1540	COG2205	protein histidine kinase activity
ACLO_1540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACLO_1540	COG2198	Histidine kinase
ACLO_1542	COG1047	Peptidyl-prolyl cis-trans
ACLO_1543	COG0517	IMP dehydrogenase activity
ACLO_1543	COG0516	GMP reductase activity
ACLO_1544	COG0154	amidase activity
ACLO_1545	COG0203	ribosomal protein L17
ACLO_1546	COG0202	RNA polymerase activity
ACLO_1547	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACLO_1548	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACLO_1549	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACLO_1550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACLO_1553	COG0473	3-isopropylmalate dehydrogenase activity
ACLO_1554	COG0066	3-isopropylmalate dehydratase activity
ACLO_1555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACLO_1559	COG3123	guanosine phosphorylase activity
ACLO_1560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACLO_1565	COG0772	Belongs to the SEDS family
ACLO_1566	COG0564	pseudouridine synthase activity
ACLO_1567	COG0366	Alpha amylase catalytic
ACLO_1567	COG3103	Sh3 type 3 domain protein
ACLO_1568	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACLO_1569	COG2884	Cell division ATP-binding protein ftsE
ACLO_1572	COG1671	Belongs to the UPF0178 family
ACLO_1574	COG0488	(ABC) transporter
ACLO_1577	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACLO_1580	COG2171	N-acyltransferase activity
ACLO_1581	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACLO_1587	COG0309	Hydrogenase expression formation protein (HypE)
ACLO_1592	COG0298	carbon dioxide binding
ACLO_1593	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACLO_1597	COG0310	cobalt ion transport
ACLO_1599	COG0840	transmembrane signaling receptor activity
ACLO_1601	COG2081	HI0933 family
ACLO_1604	COG2814	Major facilitator Superfamily
ACLO_1606	COG0301	tRNA thio-modification
ACLO_1606	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACLO_1614	COG0517	IMP dehydrogenase activity
ACLO_1618	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACLO_1621	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ACLO_1622	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ACLO_1623	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ACLO_1624	COG3259	Nickel-dependent hydrogenase
ACLO_1627	COG1049	propionate catabolic process, 2-methylcitrate cycle
ACLO_1628	COG3706	GGDEF domain
ACLO_1628	COG4251	negative regulation of phosphorylation
ACLO_1628	COG2203	Gaf domain
ACLO_1628	COG5001	Diguanylate cyclase
ACLO_1632	COG1022	Amp-dependent synthetase and ligase
ACLO_1633	COG0183	Belongs to the thiolase family
ACLO_1634	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACLO_1634	COG1024	Enoyl-CoA hydratase
ACLO_1635	COG1960	acyl-CoA dehydrogenase activity
ACLO_1649	COG0217	transcriptional regulatory protein
ACLO_1650	COG0739	heme binding
ACLO_1651	COG2853	Lipoprotein
ACLO_1654	COG1611	Belongs to the LOG family
ACLO_1655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACLO_1660	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACLO_1664	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACLO_1669	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACLO_1672	COG1696	Membrane protein involved in D-alanine export
ACLO_1676	COG0513	Belongs to the DEAD box helicase family
ACLO_1677	COG1944	ATP diphosphatase activity
ACLO_1681	COG0840	transmembrane signaling receptor activity
ACLO_1682	COG0328	RNA-DNA hybrid ribonuclease activity
ACLO_1686	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACLO_1688	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACLO_1692	COG4662	Binding-protein-dependent transport system inner membrane component
ACLO_1693	COG2998	abc-type tungstate transport system, permease component
ACLO_1694	COG0303	'Molybdopterin
ACLO_1696	COG2005	Transcriptional regulator
ACLO_1698	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACLO_1700	COG0437	4 iron, 4 sulfur cluster binding
ACLO_1707	COG2204	response regulator
ACLO_1715	COG0714	Associated with various cellular activities
ACLO_1719	COG2304	oxidoreductase activity
ACLO_1723	COG1305	Transglutaminase-like
ACLO_1726	COG1921	L-seryl-tRNASec selenium transferase activity
ACLO_1732	COG2204	response regulator
ACLO_1735	COG3437	response regulator, receiver
ACLO_1735	COG4999	Histidine kinase
ACLO_1735	COG2205	protein histidine kinase activity
ACLO_1735	COG3850	Histidine kinase
ACLO_1736	COG3437	response regulator, receiver
ACLO_1737	COG2205	protein histidine kinase activity
ACLO_1737	COG3437	response regulator, receiver
ACLO_1737	COG3850	Histidine kinase
ACLO_1737	COG4999	Histidine kinase
ACLO_1744	COG5002	protein histidine kinase activity
ACLO_1744	COG5001	Diguanylate cyclase
ACLO_1748	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACLO_1749	COG0418	dihydroorotase activity
ACLO_1750	COG0720	synthase
ACLO_1752	COG1078	dGTPase activity
ACLO_1753	COG0259	pyridoxamine-phosphate oxidase activity
ACLO_1754	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACLO_1756	COG0513	Belongs to the DEAD box helicase family
ACLO_1761	COG1984	allophanate hydrolase subunit 2
ACLO_1763	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACLO_1767	COG0842	Transport permease protein
ACLO_1768	COG1129	ABC transporter
ACLO_1768	COG0842	Transport permease protein
ACLO_1769	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACLO_1771	COG0306	phosphate transporter
ACLO_1774	COG0326	Molecular chaperone. Has ATPase activity
ACLO_1775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACLO_1776	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACLO_1779	COG3437	response regulator, receiver
ACLO_1782	COG2995	paraquat-inducible protein a
ACLO_1785	COG5001	Diguanylate cyclase
ACLO_1785	COG5002	protein histidine kinase activity
ACLO_1787	COG2205	protein histidine kinase activity
ACLO_1788	COG0745	RESPONSE REGULATOR receiver
ACLO_1789	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACLO_1790	COG0569	domain protein
ACLO_1793	COG2902	Dehydrogenase
ACLO_1795	COG4335	DNA alkylation repair
ACLO_1797	COG0010	Belongs to the arginase family
ACLO_1798	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACLO_1799	COG2207	Transcriptional regulator
ACLO_1800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACLO_1803	COG1027	Aspartate ammonia-lyase
ACLO_1804	COG0745	RESPONSE REGULATOR receiver
ACLO_1806	COG1115	amino acid carrier protein
ACLO_1807	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACLO_1808	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACLO_1809	COG1047	Peptidyl-prolyl cis-trans
ACLO_1812	COG2193	ferroxidase activity
ACLO_1813	COG0823	Involved in the tonB-independent uptake of proteins
ACLO_1815	COG0848	biopolymer transport protein
ACLO_1816	COG0811	peptide transport
ACLO_1817	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACLO_1818	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACLO_1819	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACLO_1820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACLO_1821	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACLO_1822	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACLO_1824	COG1475	DNA binding
ACLO_1825	COG1192	Involved in chromosome partitioning
ACLO_1826	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ACLO_1826	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ACLO_1828	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACLO_1829	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACLO_1830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACLO_1831	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACLO_1832	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACLO_1834	COG0358	DNA primase activity
ACLO_1836	COG0571	ribonuclease III activity
ACLO_1837	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACLO_1839	COG0501	Belongs to the peptidase M48B family
ACLO_1842	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACLO_1844	COG0706	membrane insertase activity
ACLO_1845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACLO_1846	COG0594	ribonuclease P activity
ACLO_1847	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACLO_1848	COG0542	response to heat
ACLO_1851	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACLO_1854	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACLO_1855	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACLO_1856	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACLO_1860	COG2205	protein histidine kinase activity
ACLO_1860	COG0784	Response regulator, receiver
ACLO_1862	COG0745	RESPONSE REGULATOR receiver
ACLO_1864	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACLO_1866	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACLO_1867	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACLO_1868	COG0861	Integral membrane protein TerC family
ACLO_1869	COG0726	polysaccharide deacetylase
ACLO_1870	COG0840	transmembrane signaling receptor activity
ACLO_1871	COG0840	transmembrane signaling receptor activity
ACLO_1872	COG0840	transmembrane signaling receptor activity
ACLO_1873	COG0386	Belongs to the glutathione peroxidase family
ACLO_1874	COG3201	nicotinamide mononucleotide transporter
ACLO_1876	COG3706	GGDEF domain
ACLO_1877	COG0322	excinuclease ABC activity
ACLO_1878	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACLO_1883	COG0138	bifunctional purine biosynthesis protein purh
ACLO_1884	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACLO_1886	COG0739	heme binding
ACLO_1889	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACLO_1890	COG1917	Cupin 2, conserved barrel domain protein
ACLO_1892	COG0527	aspartate kinase activity
ACLO_1893	COG0302	gtp cyclohydrolase
ACLO_1894	COG0598	Magnesium transport protein CorA
ACLO_1895	COG1459	type II secretion system
ACLO_1896	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACLO_1899	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACLO_1900	COG0606	chelatase, subunit chli
ACLO_1902	COG0242	peptide deformylase activity
ACLO_1903	COG0740	serine-type endopeptidase activity
ACLO_1904	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACLO_1905	COG2304	oxidoreductase activity
ACLO_1906	COG2326	polyphosphate kinase activity
ACLO_1909	COG1773	rubredoxin
ACLO_1912	COG0582	viral genome integration into host DNA
ACLO_1913	COG0653	protein targeting
ACLO_1948	COG4681	YaeQ
ACLO_1952	COG0626	cystathionine gamma-synthase activity
ACLO_1956	COG0745	RESPONSE REGULATOR receiver
ACLO_1957	COG0456	acetyltransferase
ACLO_1959	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ACLO_1962	COG2111	Na H antiporter
ACLO_1962	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACLO_1963	COG1006	Multisubunit Na H antiporter MnhC subunit
ACLO_1964	COG0651	ATP synthesis coupled electron transport
ACLO_1965	COG1863	multisubunit Na H antiporter MnhE subunit
ACLO_1966	COG2212	antiporter activity
ACLO_1968	COG1028	Short-chain dehydrogenase reductase Sdr
ACLO_1971	COG0840	transmembrane signaling receptor activity
ACLO_1972	COG2200	EAL domain
ACLO_1973	COG1116	anion transmembrane transporter activity
ACLO_1975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACLO_1975	COG1116	anion transmembrane transporter activity
ACLO_1976	COG0243	molybdopterin cofactor binding
ACLO_1977	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACLO_1980	COG1858	cytochrome C peroxidase
ACLO_1987	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACLO_1988	COG0840	transmembrane signaling receptor activity
ACLO_1990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACLO_2018	COG4974	Belongs to the 'phage' integrase family
ACLO_2019	COG0668	transmembrane transport
ACLO_2025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACLO_2028	COG0348	domain, Protein
ACLO_2029	COG4191	Histidine kinase
ACLO_2030	COG4753	response regulator
ACLO_2030	COG2207	Transcriptional regulator
ACLO_2038	COG0716	FMN binding
ACLO_2041	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACLO_2044	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACLO_2045	COG0159	tryptophan synthase activity
ACLO_2046	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACLO_2047	COG2255	four-way junction helicase activity
ACLO_2048	COG0628	permease
ACLO_2050	COG4628	conserved protein (DUF2132)
ACLO_2061	COG0731	radical SAM domain protein
ACLO_2062	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACLO_2064	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACLO_2067	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACLO_2069	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACLO_2072	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACLO_2073	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACLO_2073	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACLO_2074	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACLO_2075	COG0859	PFAM glycosyl transferase family 9
ACLO_2078	COG1216	Glycosyl transferase, family 2
ACLO_2081	COG0438	transferase activity, transferring glycosyl groups
ACLO_2082	COG1216	Glycosyl transferase, family 2
ACLO_2085	COG1216	Glycosyl transferase, family 2
ACLO_2094	COG0859	PFAM glycosyl transferase family 9
ACLO_2096	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACLO_2098	COG0493	'glutamate synthase
ACLO_2099	COG0067	glutamate synthase
ACLO_2099	COG0070	glutamate synthase
ACLO_2099	COG0069	glutamate synthase activity
ACLO_2100	COG0584	glycerophosphoryl diester phosphodiesterase
ACLO_2113	COG1086	Polysaccharide biosynthesis protein
ACLO_2115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACLO_2118	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
ACLO_2128	COG0463	Glycosyl transferase, family 2
ACLO_2131	COG4641	Protein conserved in bacteria
ACLO_2131	COG0438	transferase activity, transferring glycosyl groups
ACLO_2132	COG0110	maltose O-acetyltransferase activity
ACLO_2135	COG0546	phosphoglycolate phosphatase activity
ACLO_2136	COG1083	cytidylyl-transferase
ACLO_2145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACLO_2146	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACLO_2147	COG0284	orotidine-5'-phosphate decarboxylase activity
ACLO_2153	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACLO_2157	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACLO_2161	COG1739	Uncharacterized protein family UPF0029
ACLO_2162	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ACLO_2163	COG0196	riboflavin kinase activity
ACLO_2164	COG2226	methyltransferase
ACLO_2165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACLO_2167	COG0277	FAD linked oxidase domain protein
ACLO_2176	COG0542	response to heat
ACLO_2177	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACLO_2178	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACLO_2181	COG2030	dehydratase
ACLO_2186	COG1970	mechanosensitive ion channel activity
ACLO_2187	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACLO_2193	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACLO_2194	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACLO_2195	COG1157	protein secretion by the type III secretion system
ACLO_2197	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACLO_2201	COG1677	Flagellar hook-basal body complex protein FliE
ACLO_2203	COG0455	bacterial-type flagellum organization
ACLO_2204	COG1419	protein localization to endoplasmic reticulum
ACLO_2209	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACLO_2214	COG1749	Flagellar hook protein flgE
ACLO_2215	COG4786	Flagellar basal body rod
ACLO_2217	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACLO_2219	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACLO_2220	COG1766	The M ring may be actively involved in energy transduction
ACLO_2221	COG1815	bacterial-type flagellum-dependent cell motility
ACLO_2222	COG4786	Flagellar basal body rod
ACLO_2224	COG0745	RESPONSE REGULATOR receiver
ACLO_2228	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACLO_2230	COG0228	four-way junction DNA binding
ACLO_2231	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACLO_2232	COG0564	pseudouridine synthase activity
ACLO_2233	COG1519	Transferase
ACLO_2235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACLO_2236	COG0752	glycyl-tRNA synthetase alpha subunit
ACLO_2238	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACLO_2241	COG0840	transmembrane signaling receptor activity
ACLO_2241	COG0840	transmembrane signaling receptor activity
ACLO_2242	COG0497	DNA recombination
ACLO_2243	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACLO_2244	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACLO_2245	COG0049	tRNA binding
ACLO_2246	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACLO_2259	COG3706	GGDEF domain
ACLO_2264	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACLO_2276	COG0582	viral genome integration into host DNA
ACLO_2279	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACLO_2280	COG0085	RNA polymerase activity
ACLO_2281	COG0222	ribosome binding
ACLO_2282	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACLO_2283	COG0081	regulation of translation
ACLO_2284	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACLO_2285	COG0250	Participates in transcription elongation, termination and antitermination
ACLO_2288	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACLO_2289	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACLO_2294	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACLO_2295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACLO_2296	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACLO_2297	COG0444	Belongs to the ABC transporter superfamily
ACLO_2299	COG0174	glutamine synthetase
ACLO_2301	COG2199	diguanylate cyclase activity
ACLO_2302	COG0314	molybdopterin synthase activity
ACLO_2304	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACLO_2307	COG0772	Belongs to the SEDS family
ACLO_2309	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACLO_2317	COG0512	Glutamine amidotransferase of anthranilate synthase
ACLO_2318	COG1840	ABC-type Fe3 transport system, periplasmic component
ACLO_2320	COG3842	ATPase activity
ACLO_2327	COG2183	response to ionizing radiation
ACLO_2328	COG5001	Diguanylate cyclase
ACLO_2328	COG5002	protein histidine kinase activity
ACLO_2329	COG0251	oxidation-reduction process
ACLO_2332	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACLO_2333	COG0586	Pfam SNARE associated Golgi protein
ACLO_2335	COG0335	large ribosomal subunit rRNA binding
ACLO_2336	COG0336	Belongs to the RNA methyltransferase TrmD family
ACLO_2338	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACLO_2339	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACLO_2340	COG0356	it plays a direct role in the translocation of protons across the membrane
ACLO_2342	COG1074	ATP-dependent DNA helicase activity
ACLO_2343	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACLO_2344	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACLO_2346	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACLO_2349	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACLO_2351	COG0303	'Molybdopterin
ACLO_2352	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACLO_2354	COG0602	queuosine metabolic process
ACLO_2356	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACLO_2357	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACLO_2358	COG0825	malonyl-CoA metabolic process
ACLO_2359	COG0537	adenosine 5'-monophosphoramidase activity
ACLO_2360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACLO_2361	COG0072	phenylalanine-tRNA ligase activity
ACLO_2361	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACLO_2362	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACLO_2363	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACLO_2364	COG0539	negative regulation of cytoplasmic translation
ACLO_2364	COG1185	polyribonucleotide nucleotidyltransferase activity
ACLO_2365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACLO_2366	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACLO_2367	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACLO_2367	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACLO_2368	COG0779	Required for maturation of 30S ribosomal subunits
ACLO_2369	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACLO_2370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACLO_2372	COG0083	homoserine kinase activity
ACLO_2374	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACLO_2376	COG2404	hydrolase activity, acting on ester bonds
ACLO_2377	COG0157	Belongs to the NadC ModD family
ACLO_2379	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACLO_2381	COG4773	Receptor
ACLO_2387	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACLO_2395	COG3278	Belongs to the heme-copper respiratory oxidase family
ACLO_2396	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACLO_2397	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACLO_2398	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACLO_2399	COG0210	DNA helicase
ACLO_2401	COG1242	4 iron, 4 sulfur cluster binding
ACLO_2402	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACLO_2403	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACLO_2404	COG0492	ferredoxin-NADP+ reductase activity
ACLO_2405	COG3118	belongs to the thioredoxin family
ACLO_2406	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACLO_2411	COG0791	NLP P60 protein
ACLO_2412	COG0791	NLP P60 protein
ACLO_2415	COG0424	maF-like protein
ACLO_2417	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACLO_2418	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACLO_2419	COG1605	Chorismate mutase
ACLO_2419	COG0077	Prephenate dehydratase
ACLO_2420	COG0019	diaminopimelate decarboxylase activity
ACLO_2421	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACLO_2422	COG0149	triose-phosphate isomerase activity
ACLO_2423	COG0126	phosphoglycerate kinase activity
ACLO_2424	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACLO_2425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACLO_2427	COG0018	arginyl-trna synthetase
ACLO_2428	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACLO_2429	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACLO_2430	COG0204	Acyl-transferase
ACLO_2432	COG0047	phosphoribosylformylglycinamidine synthase activity
ACLO_2433	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACLO_2434	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACLO_2435	COG0793	Belongs to the peptidase S41A family
ACLO_2438	COG0585	pseudouridine synthase activity
ACLO_2441	COG0577	efflux transmembrane transporter activity
ACLO_2441	COG1136	(ABC) transporter
ACLO_2447	COG0129	dihydroxy-acid dehydratase activity
ACLO_2449	COG0745	RESPONSE REGULATOR receiver
ACLO_2450	COG0642	Histidine kinase
ACLO_2452	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACLO_2453	COG0702	epimerase
ACLO_2456	COG1492	cobalamin metabolic process
ACLO_2460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACLO_2461	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACLO_2463	COG2095	MarC family integral membrane protein
ACLO_2464	COG1083	cytidylyl-transferase
ACLO_2464	COG2755	lipolytic protein G-D-S-L family
ACLO_2465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACLO_2468	COG4232	protein-disulfide reductase activity
ACLO_2469	COG3118	belongs to the thioredoxin family
ACLO_2470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACLO_2473	COG0189	ligase activity
ACLO_2476	COG2200	EAL domain
ACLO_2476	COG2199	diguanylate cyclase activity
ACLO_2476	COG3287	FIST C domain
ACLO_2477	COG0688	phosphatidylethanolamine metabolic process
ACLO_2479	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACLO_2481	COG0443	Heat shock 70 kDa protein
ACLO_2482	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACLO_2484	COG2358	TRAP transporter, solute receptor (TAXI family
ACLO_2486	COG2197	response regulator
ACLO_2488	COG0101	tRNA pseudouridine synthase activity
ACLO_2491	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACLO_2492	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACLO_2493	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACLO_2495	COG4581	dead DEAH box helicase
ACLO_2496	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACLO_2502	COG1083	cytidylyl-transferase
ACLO_2503	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACLO_2505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACLO_2506	COG1011	Hydrolase
ACLO_2509	COG1233	COG1233 Phytoene dehydrogenase and related
ACLO_2510	COG2089	acid synthase
ACLO_2512	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACLO_2516	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACLO_2517	COG0148	phosphopyruvate hydratase activity
ACLO_2520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACLO_2524	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACLO_2526	COG1007	ATP synthesis coupled electron transport
ACLO_2528	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACLO_2529	COG0713	ATP synthesis coupled electron transport
ACLO_2530	COG0839	Belongs to the complex I subunit 6 family
ACLO_2531	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_2532	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACLO_2536	COG0649	NAD binding
ACLO_2537	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_2538	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_2539	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_2540	COG1222	aaa ATPase
ACLO_2545	COG0659	secondary active sulfate transmembrane transporter activity
ACLO_2546	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACLO_2547	COG1252	NADH dehydrogenase
ACLO_2548	COG0733	neurotransmitter:sodium symporter activity
ACLO_2550	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACLO_2552	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACLO_2553	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACLO_2554	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACLO_2558	COG0445	tRNA wobble uridine modification
ACLO_2561	COG0348	domain, Protein
ACLO_2562	COG0504	CTP synthase activity
ACLO_2563	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACLO_2563	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ACLO_2569	COG0587	DNA-directed DNA polymerase activity
ACLO_2570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACLO_2572	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACLO_2573	COG0315	cyclic pyranopterin monophosphate synthase activity
ACLO_2580	COG0670	Belongs to the BI1 family
ACLO_2582	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACLO_2584	COG0233	cytoplasmic translational termination
ACLO_2585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACLO_2587	COG2814	Major facilitator Superfamily
ACLO_2588	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACLO_2588	COG3264	Mechanosensitive ion channel
ACLO_2590	COG3022	response to hydroperoxide
ACLO_2591	COG3012	SEC-C Motif Domain Protein
ACLO_2596	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACLO_2597	COG1012	belongs to the aldehyde dehydrogenase family
ACLO_2599	COG1704	LemA family
ACLO_2602	COG0546	phosphoglycolate phosphatase activity
ACLO_2604	COG0783	Belongs to the Dps family
ACLO_2606	COG2814	Major facilitator Superfamily
ACLO_2607	COG0840	transmembrane signaling receptor activity
ACLO_2616	COG2081	HI0933 family
ACLO_2620	COG1959	2 iron, 2 sulfur cluster binding
ACLO_2623	COG0175	sulfate reduction
ACLO_2624	COG0175	sulfate reduction
ACLO_2625	COG2895	sulfate adenylyltransferase (ATP) activity
ACLO_2626	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACLO_2627	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACLO_2630	COG1408	metallophosphoesterase
ACLO_2631	COG0071	Belongs to the small heat shock protein (HSP20) family
ACLO_2634	COG1305	Transglutaminase-like
ACLO_2635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACLO_2636	COG4208	sulfate ABC transporter
ACLO_2637	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACLO_2638	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACLO_2639	COG1959	2 iron, 2 sulfur cluster binding
ACLO_2643	COG2308	Evidence 4 Homologs of previously reported genes of
ACLO_2647	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACLO_2651	COG0745	RESPONSE REGULATOR receiver
ACLO_2652	COG0642	Histidine kinase
ACLO_2654	COG0425	Belongs to the sulfur carrier protein TusA family
ACLO_2655	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ACLO_2656	COG2066	Belongs to the glutaminase family
ACLO_2657	COG2860	membrane
ACLO_2659	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACLO_2660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACLO_a0001	COG0305	Participates in initiation and elongation during chromosome replication
ACLO_a0003	COG1475	DNA binding
ACLO_a0004	COG1192	Involved in chromosome partitioning
ACLO_a0006	COG4771	TonB-dependent receptor
ACLO_a0013	COG4771	TonB-dependent receptor
ACLO_a0016	COG0745	RESPONSE REGULATOR receiver
ACLO_a0018	COG3550	peptidyl-serine autophosphorylation
ACLO_a0028	COG0840	transmembrane signaling receptor activity
ACLO_a0029	COG0840	transmembrane signaling receptor activity
ACLO_a0030	COG0840	transmembrane signaling receptor activity
ACLO_a0034	COG0840	transmembrane signaling receptor activity
ACLO_a0036	COG0643	Histidine kinase
ACLO_a0036	COG2198	Histidine kinase
ACLO_a0038	COG2203	Gaf domain
ACLO_a0038	COG3706	GGDEF domain
ACLO_a0038	COG4251	negative regulation of phosphorylation
ACLO_a0038	COG5001	Diguanylate cyclase
ACLO_a0043	COG1518	maintenance of DNA repeat elements
ACLO_a0046	COG1373	ATPase (AAA superfamily
ACLO_a0062	COG1337	RAMP superfamily
ACLO_a0069	COG3550	peptidyl-serine autophosphorylation
ACLO_a0071	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ACLO_a0086	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACLO_a0091	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACLO_a0094	COG0745	RESPONSE REGULATOR receiver
ACLO_a0098	COG4774	siderophore transport
ACLO_a0100	COG5001	Diguanylate cyclase
ACLO_a0100	COG5002	protein histidine kinase activity
ACLO_a0108	COG2207	Transcriptional regulator
ACLO_a0117	COG4753	response regulator
ACLO_a0117	COG2207	Transcriptional regulator
ACLO_a0118	COG3852	Histidine kinase
ACLO_a0121	COG0114	fumarate hydratase activity
ACLO_a0129	COG0840	transmembrane signaling receptor activity
ACLO_a0131	COG1605	Chorismate mutase
ACLO_a0131	COG0077	Prephenate dehydratase
ACLO_a0134	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACLO_a0135	COG2267	carboxylic ester hydrolase activity
ACLO_a0136	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACLO_a0140	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ACLO_a0145	COG0543	2 iron, 2 sulfur cluster binding
ACLO_a0145	COG0633	Ferredoxin
ACLO_a0149	COG0730	response to heat
ACLO_a0157	COG2204	response regulator
ACLO_a0158	COG1028	Short-chain dehydrogenase reductase Sdr
ACLO_a0159	COG0473	3-isopropylmalate dehydrogenase activity